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Recent research has highlighted the potential neuroprotective functions of TTR in the setting of Alzheimer\u2019s disease (AD), which is the most common form of dementia and is caused by the deposition of amyloid beta (A\u03b2) and the resulting cytotoxic effects. This paper explores the mechanisms of TTR protective action, including its interaction with A\u03b2 to prevent fibril formation and promote A\u03b2 clearance from the brain. It also synthesizes experimental evidence suggesting that enhanced TTR stability may mitigate neurodegeneration and cognitive decline in AD. Potential therapeutic strategies such as small molecule stabilizers of TTR are discussed, highlighting their role in enhancing TTR binding to A\u03b2 and facilitating its clearance. By consolidating current knowledge and proposing directions for future research, this review aims to underscore the significance of TTR as a neuroprotective factor in AD and the potential implications for future research.<\/jats:p>","DOI":"10.1007\/s12035-024-04442-8","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T21:02:16Z","timestamp":1724792536000},"page":"2945-2954","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Tetrameric Transthyretin as a Protective Factor Against Alzheimer\u2019s Disease"],"prefix":"10.1007","volume":"62","author":[{"given":"Camilla","family":"Corino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Aimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Luigetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Ciccone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Fu","family":"Ferrari Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Panichella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Musetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Castiglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Vergaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Emdin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Franzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"4442_CR1","unstructured":"World Health Organization, Dementia, 2023. https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/dementia (last access May 10, 2024)."},{"key":"4442_CR2","unstructured":"Alzheimer's Disease International, Dementia Statistics. https:\/\/www.alzint.org\/about\/dementia-facts-figures\/dementia-statistics\/ (last access May 10, 2024)."},{"key":"4442_CR3","unstructured":"World Health Organization, The top 10 causes of death, 2020. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/the-top-10-causes-of-death (last access May 10, 2024)."},{"key":"4442_CR4","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","author":"G McKhann","year":"1984","unstructured":"McKhann G, Drachman D, Folstein M et al (1984) Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease. 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