{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:14:11Z","timestamp":1793812451753,"version":"4.6.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31971277"],"award-info":[{"award-number":["31971277"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s12035-024-04483-z","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T18:04:01Z","timestamp":1729188241000},"page":"4172-4189","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Toll-Like Receptor 4 (TLR4) Promotes DRG Regeneration and Repair after Sciatic Nerve Injury via the ERK-NF-kB Pathway"],"prefix":"10.1007","volume":"62","author":[{"given":"Yiming","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maorong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxi","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyuan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengbing","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"4483_CR1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0074-7742(09)87008-6","volume":"87","author":"M Siemionow","year":"2009","unstructured":"Siemionow M, Brzezicki G (2009) Chapter 8: Current techniques and concepts in peripheral nerve repair[J]. Int Rev Neurobiol 87:141\u201372","journal-title":"Int Rev Neurobiol"},{"issue":"Suppl 1","key":"4483_CR2","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1093\/pm\/pnz012","volume":"20","author":"MF Esposito","year":"2019","unstructured":"Esposito MF, Malayil R, Hanes M et al (2019) Unique characteristics of the dorsal root ganglion as a target for neuromodulation[J]. Pain Med 20(Suppl 1):S23-s30","journal-title":"Pain Med"},{"key":"4483_CR3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.pneurobio.2018.05.002","volume":"168","author":"AI Nascimento","year":"2018","unstructured":"Nascimento AI, Mar FM, Sousa MM (2018) The intriguing nature of dorsal root ganglion neurons: linking structure with polarity and function[J]. Prog Neurobiol 168:86\u2013103","journal-title":"Prog Neurobiol"},{"key":"4483_CR4","doi-asserted-by":"crossref","first-page":"914344","DOI":"10.3389\/fnins.2022.914344","volume":"16","author":"Z Wang","year":"2022","unstructured":"Wang Z, Zhang D, Yi XZ et al (2022) Effects of regenerative peripheral nerve interface on dorsal root ganglia neurons following peripheral axotomy[J]. Front Neurosci 16:914344","journal-title":"Front Neurosci"},{"issue":"4","key":"4483_CR5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pneurobio.2007.06.005","volume":"82","author":"X Navarro","year":"2007","unstructured":"Navarro X, Viv\u00f3 M, Valero-Cabr\u00e9 A (2007) Neural plasticity after peripheral nerve injury and regeneration[J]. Prog Neurobiol 82(4):163\u2013201","journal-title":"Prog Neurobiol"},{"key":"4483_CR6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","volume":"21","author":"K Takeda","year":"2003","unstructured":"Takeda K, Kaisho T, Akira S (2003) Toll-like receptors[J]. Annu Rev Immunol 21:335\u2013376","journal-title":"Annu Rev Immunol"},{"issue":"3","key":"4483_CR7","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1128\/IAI.74.3.1692-1698.2006","volume":"74","author":"R Higgs","year":"2006","unstructured":"Higgs R, Cormican P, Cahalane S et al (2006) Induction of a novel chicken toll-like receptor following Salmonella enterica serovar Typhimurium infection[J]. Infect Immun 74(3):1692\u20131698","journal-title":"Infect Immun"},{"issue":"9","key":"4483_CR8","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.biocel.2007.04.021","volume":"39","author":"SK Biswas","year":"2007","unstructured":"Biswas SK, Tergaonkar V (2007) Myeloid differentiation factor 88-independent toll-like receptor pathway: sustaining inflammation or promoting tolerance?[J]. Int J Biochem Cell Biol 39(9):1582\u20131592","journal-title":"Int J Biochem Cell Biol"},{"key":"4483_CR9","first-page":"14.12.1","volume":"14","author":"K. Takeda","year":"2007","unstructured":"Takeda K., Akira S. (2007) Toll-like receptors [J]. Curr Protoc Immunol 14:14.12.1-14.12.13","journal-title":"Curr Protoc Immunol"},{"issue":"3","key":"4483_CR10","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.3892\/ol.2016.4159","volume":"11","author":"MF Al-Harras","year":"2016","unstructured":"Al-Harras MF, Houssen ME, Shaker ME et al (2016) Polymorphisms of glutathione S-transferase \u03c0 1 and toll-like receptors 2 and 9: association with breast cancer susceptibility[J]. Oncol Lett 11(3):2182\u20132188","journal-title":"Oncol Lett"},{"issue":"14","key":"4483_CR11","doi-asserted-by":"crossref","first-page":"8514","DOI":"10.1073\/pnas.1432609100","volume":"100","author":"S Lehnardt","year":"2003","unstructured":"Lehnardt S, Massillon L, Follett P et al (2003) Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway[J]. Proc Natl Acad Sci U S A 100(14):8514\u20138519","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"34","key":"4483_CR12","doi-asserted-by":"crossref","first-page":"13798","DOI":"10.1073\/pnas.0702553104","volume":"104","author":"SC Tang","year":"2007","unstructured":"Tang SC, Arumugam TV, Xu X et al (2007) Pivotal role for neuronal toll-like receptors in ischemic brain injury and functional deficits[J]. Proc Natl Acad Sci USA 104(34):13798\u201313803","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"4483_CR13","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1084\/jem.20050914","volume":"202","author":"FJ Barrat","year":"2005","unstructured":"Barrat FJ, Meeker T, Gregorio J et al (2005) Nucleic acids of mammalian origin can act as endogenous ligands for toll-like receptors and may promote systemic lupus erythematosus[J]. J Exp Med 202(8):1131\u20131139","journal-title":"J Exp Med"},{"issue":"13 Suppl","key":"4483_CR14","first-page":"S295","volume":"18","author":"A Gibofsky","year":"2012","unstructured":"Gibofsky A (2012) Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis[J]. Am J Manag Care 18(13 Suppl):S295-302","journal-title":"Am J Manag Care"},{"issue":"2","key":"4483_CR15","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.metabol.2010.01.005","volume":"60","author":"S Devaraj","year":"2011","unstructured":"Devaraj S, Jialal I, Yun JM et al (2011) Demonstration of increased Toll-like receptor 2 and Toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications[J]. Metabolism 60(2):256\u2013259","journal-title":"Metabolism"},{"issue":"26","key":"4483_CR16","doi-asserted-by":"crossref","first-page":"22564","DOI":"10.18632\/oncotarget.4197","volume":"6","author":"Y Luo","year":"2015","unstructured":"Luo Y, Jiang QW, Wu JY et al (2015) Regulation of migration and invasion by toll-like receptor-9 signaling network in prostate cancer[J]. Oncotarget 6(26):22564\u201322574","journal-title":"Oncotarget"},{"issue":"11","key":"4483_CR17","doi-asserted-by":"crossref","first-page":"e0141865","DOI":"10.1371\/journal.pone.0141865","volume":"10","author":"M Ravishankar Ram","year":"2015","unstructured":"Ravishankar Ram M, Goh KL, Leow AH et al (2015) Polymorphisms at locus 4p14 of toll-like receptors TLR-1 and TLR-10 confer susceptibility to gastric carcinoma in helicobacter pylori infection[J]. PLoS ONE 10(11):e0141865","journal-title":"PLoS ONE"},{"issue":"32","key":"4483_CR18","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.3748\/wjg.v17.i32.3745","volume":"17","author":"I Sheyhidin","year":"2011","unstructured":"Sheyhidin I, Nabi G, Hasim A et al (2011) Overexpression of TLR3, TLR4, TLR7 and TLR9 in esophageal squamous cell carcinoma[J]. World J Gastroenterol 17(32):3745\u20133751","journal-title":"World J Gastroenterol"},{"issue":"4","key":"4483_CR19","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1365-2559.2011.03991.x","volume":"59","author":"JH Kauppila","year":"2011","unstructured":"Kauppila JH, Takala H, Selander KS et al (2011) Increased Toll-like receptor 9 expression indicates adverse prognosis in oesophageal adenocarcinoma[J]. Histopathology 59(4):643\u2013649","journal-title":"Histopathology"},{"issue":"5","key":"4483_CR20","doi-asserted-by":"crossref","first-page":"344","DOI":"10.5732\/cjc.010.10456","volume":"30","author":"A Hasimu","year":"2011","unstructured":"Hasimu A, Ge L, Li QZ et al (2011) Expressions of toll-like receptors 3, 4, 7, and 9 in cervical lesions and their correlation with HPV16 infection in Uighur women[J]. Chin J Cancer 30(5):344\u2013350","journal-title":"Chin J Cancer"},{"issue":"3","key":"4483_CR21","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3892\/ijo.2015.3069","volume":"47","author":"T Grimmig","year":"2015","unstructured":"Grimmig T, Matthes N, Hoeland K et al (2015) TLR7 and TLR8 expression increases tumor cell proliferation and promotes chemoresistance in human pancreatic cancer[J]. Int J Oncol 47(3):857\u2013866","journal-title":"Int J Oncol"},{"issue":"2","key":"4483_CR22","first-page":"126","volume":"8","author":"J Gu","year":"2018","unstructured":"Gu J, Liu Y, Xie B et al (2018) Roles of toll-like receptors: from inflammation to lung cancer progression[J]. Biomed Rep 8(2):126\u2013132","journal-title":"Biomed Rep"},{"issue":"6","key":"4483_CR23","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/sji.12174","volume":"79","author":"X Xu","year":"2014","unstructured":"Xu X, Zhu H, Wang T et al (2014) Exogenous high-mobility group box 1 inhibits apoptosis and promotes the proliferation of lewis cells via RAGE\/TLR4-dependent signal pathways[J]. Scand J Immunol 79(6):386\u2013394","journal-title":"Scand J Immunol"},{"issue":"5566","key":"4483_CR24","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.1071059","volume":"296","author":"P Matzinger","year":"2002","unstructured":"Matzinger P (2002) The danger model: a renewed sense of self[J]. Science 296(5566):301\u2013305","journal-title":"Science"},{"key":"4483_CR25","doi-asserted-by":"crossref","unstructured":"Beg A A (2002) Endogenous ligands of toll-like receptors: implications for regulating inflammatory and immune responses. Trends in Immunology 23(11):0\u2013512","DOI":"10.1016\/S1471-4906(02)02317-7"},{"key":"4483_CR26","doi-asserted-by":"crossref","first-page":"151526","DOI":"10.1016\/j.aanat.2020.151526","volume":"231","author":"F Arnaboldi","year":"2020","unstructured":"Arnaboldi F, Sommariva M, Opizzi E et al (2020) Expression of toll-like receptors 4 and 7 in murine peripheral nervous system development[J]. Ann Anat 231:151526","journal-title":"Ann Anat"},{"key":"4483_CR27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuroscience.2014.02.041","volume":"267","author":"KH Tse","year":"2014","unstructured":"Tse KH, Chow KB, Leung WK et al (2014) Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via toll-like receptor-4 dependent pathways[J]. Neuroscience 267:241\u2013251","journal-title":"Neuroscience"},{"issue":"1","key":"4483_CR28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/mus.24082","volume":"50","author":"M Li","year":"2014","unstructured":"Li M, Zhang P, Guo W et al (2014) Protein expression profiling during Wallerian degeneration after rat sciatic nerve injury[J]. Muscle Nerve 50(1):73\u201378","journal-title":"Muscle Nerve"},{"issue":"46","key":"4483_CR29","doi-asserted-by":"crossref","first-page":"80741","DOI":"10.18632\/oncotarget.20206","volume":"8","author":"CH Hsieh","year":"2017","unstructured":"Hsieh CH, Rau CS, Kuo PJ et al (2017) Knockout of toll-like receptor impairs nerve regeneration after a crush injury[J]. Oncotarget 8(46):80741\u201380756","journal-title":"Oncotarget"},{"issue":"1","key":"4483_CR30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1423-0127-20-62","volume":"20","author":"SC Wu","year":"2013","unstructured":"Wu SC, Rau CS, Lu TH et al (2013) Knockout of TLR4 and TLR2 impair the nerve regeneration by delayed demyelination but not remyelination[J]. J Biomed Sci 20(1):62","journal-title":"J Biomed Sci"},{"issue":"23","key":"4483_CR31","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.1523\/JNEUROSCI.0353-16.2016","volume":"36","author":"JS Church","year":"2016","unstructured":"Church JS, Kigerl KA, Lerch JK et al (2016) TLR4 deficiency impairs oligodendrocyte formation in the injured spinal cord[J]. J Neurosci 36(23):6352\u20136364","journal-title":"J Neurosci"},{"key":"4483_CR32","first-page":"169","volume":"336","author":"D Kim","year":"2009","unstructured":"Kim D, Lee S, Lee SJ (2009) Toll-like receptors in peripheral nerve injury and neuropathic pain [J]. Current Topics in Microbiology & Immunology 336:169","journal-title":"Current Topics in Microbiology & Immunology"},{"issue":"1","key":"4483_CR33","doi-asserted-by":"crossref","first-page":"11179","DOI":"10.1038\/s41598-018-28516-5","volume":"8","author":"H Zhang","year":"2018","unstructured":"Zhang H, Shao Z, Zhu Y et al (2018) Toll-Like receptor 4 (TLR4) expression affects schwann cell behavior in vitro[J]. Sci Rep 8(1):11179","journal-title":"Sci Rep"},{"key":"4483_CR34","doi-asserted-by":"crossref","unstructured":"Bautista M, Katselis G S, Chowdhury B et al. (2023) Comparative proteomics analysis of growth-primed adult dorsal root ganglia reveals key molecular mediators for peripheral nerve regeneration. eNeuro 10(1)","DOI":"10.1523\/ENEURO.0168-22.2022"},{"issue":"6","key":"4483_CR35","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1189\/jlb.1209775","volume":"87","author":"C Erridge","year":"2010","unstructured":"Erridge C (2010) Endogenous ligands of TLR2 and TLR4: agonists or assistants?[J]. J Leukoc Biol 87(6):989\u2013999","journal-title":"J Leukoc Biol"},{"key":"4483_CR36","unstructured":"Carpenter R, Brady MF (2022) BAX Gene, StatPearls, Treasure Island (FL): Stat Pearls Publishing Copyright \u00a9 2022, Stat Pearls Publishing LLC"},{"issue":"5","key":"4483_CR37","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation[J]. Cell 144(5):646\u2013674","journal-title":"Cell"},{"issue":"1\u20132","key":"4483_CR38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11010-016-2866-z","volume":"425","author":"Q Shu","year":"2017","unstructured":"Shu Q, Zhang J, Ma W et al (2017) Orexin-A promotes glu uptake by OX1R\/PKC\u03b1\/ERK1\/2\/GLT-1 pathway in astrocytes and protects co-cultured astrocytes and neurons against apoptosis in anoxia\/hypoglycemic injury in vitro[J]. Mol Cell Biochem 425(1\u20132):103\u2013112","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"4483_CR39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00210-010-0575-9","volume":"383","author":"Y Peng","year":"2011","unstructured":"Peng Y, Hu Y, Feng N et al (2011) L-3-n-butyl-phthalide alleviates hydrogen peroxide-induced apoptosis by PKC pathway in human neuroblastoma SK-N-SH cells[J]. Naunyn Schmiedebergs Arch Pharmacol 383(1):91\u201399","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"4483_CR40","doi-asserted-by":"crossref","first-page":"567537","DOI":"10.3389\/fcell.2020.567537","volume":"8","author":"D Chung","year":"2020","unstructured":"Chung D, Shum A, Caraveo G (2020) GAP-43 and BASP1 in axon regeneration: implications for the treatment of neurodegenerative diseases[J]. Front Cell Dev Biol 8:567537","journal-title":"Front Cell Dev Biol"},{"issue":"12","key":"4483_CR41","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.spinee.2016.06.020","volume":"16","author":"B He","year":"2016","unstructured":"He B, Nan G (2016) Neuronal regeneration after acute spinal cord injury in adult rats[J]. Spine J 16(12):1459\u20131467","journal-title":"Spine J"},{"issue":"6\u20137","key":"4483_CR42","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s11064-005-6961-x","volume":"30","author":"MP Mattson","year":"2005","unstructured":"Mattson MP (2005) NF-kappaB in the survival and plasticity of neurons[J]. Neurochem Res 30(6\u20137):883\u2013893","journal-title":"Neurochem Res"},{"issue":"8","key":"4483_CR43","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/ar.24126","volume":"302","author":"B Hausott","year":"2019","unstructured":"Hausott B, Klimaschewski L (2019) Promotion of peripheral nerve regeneration by stimulation of the extracellular signal-regulated kinase (ERK) pathway[J]. Anat Rec (Hoboken) 302(8):1261\u20131267","journal-title":"Anat Rec (Hoboken)"},{"key":"4483_CR44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2013.11.007","volume":"252","author":"JE Shin","year":"2014","unstructured":"Shin JE, Geisler S, Diantonio A (2014) Dynamic regulation of SCG10 in regenerating axons after injury[J]. Exp Neurol 252:1\u201311","journal-title":"Exp Neurol"},{"issue":"2","key":"4483_CR45","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00418-019-01779-3","volume":"152","author":"P Dubov\u00fd","year":"2019","unstructured":"Dubov\u00fd P, Hradilov\u00e1-Sv\u00ed\u017eensk\u00e1 I, Klus\u00e1kov\u00e1 I et al (2019) Interleukin-6 contributes to initiation of neuronal regeneration program in the remote dorsal root ganglia neurons after sciatic nerve injury[J]. Histochem Cell Biol 152(2):109\u2013117","journal-title":"Histochem Cell Biol"},{"issue":"46","key":"4483_CR46","doi-asserted-by":"crossref","first-page":"12565","DOI":"10.1523\/JNEUROSCI.3027-07.2007","volume":"27","author":"A Boivin","year":"2007","unstructured":"Boivin A, Pineau I, Barrette B et al (2007) Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury [J]. Journal of Neuroscience 27(46):12565\u201312576","journal-title":"Journal of Neuroscience"},{"key":"4483_CR47","doi-asserted-by":"crossref","unstructured":"Perrin FE, Lacroix S, Marcelino Avil\u00e9s-Trigueros et al. (2005) Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration. Brain 128(Pt 4):854\u2013866","DOI":"10.1093\/brain\/awh407"},{"issue":"1\u20132","key":"4483_CR48","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0165-5728(00)00343-X","volume":"110","author":"H Siebert","year":"2000","unstructured":"Siebert H, Sachse A, Kuziel WA et al (2000) The chemokine receptor CCR2 is involved in macrophage recruitment to the injured peripheral nervous system [J]. Journal of Neuroimmunology 110(1\u20132):177\u2013185","journal-title":"Journal of Neuroimmunology"},{"issue":"1","key":"4483_CR49","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.expneurol.2006.05.024","volume":"202","author":"S Karanth","year":"2006","unstructured":"Karanth S, Yang G, Yeh J et al (2006) Nature of signals that initiate the immune response during Wallerian degeneration of peripheral nerves[J]. Exp Neurol 202(1):161\u2013166","journal-title":"Exp Neurol"},{"issue":"1","key":"4483_CR50","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1471-4159.2007.04524.x","volume":"102","author":"KA Kigerl","year":"2007","unstructured":"Kigerl KA, Lai W, Rivest S et al (2007) Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury[J]. J Neurochem 102(1):37\u201350","journal-title":"J Neurochem"},{"issue":"1","key":"4483_CR51","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.smim.2006.12.004","volume":"19","author":"T Kawai","year":"2007","unstructured":"Kawai T, Akira S (2007) TLR signaling[J]. Semin Immunol 19(1):24\u201332","journal-title":"Semin Immunol"},{"issue":"9","key":"4483_CR52","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.2174\/1871527313666140806124850","volume":"13","author":"ME Gambuzza","year":"2014","unstructured":"Gambuzza ME, Sofo V, Salmeri FM et al (2014) Toll-like receptors in Alzheimer\u2019s disease: a therapeutic perspective[J]. CNS Neurol Disord Drug Targets 13(9):1542\u20131558","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"5","key":"4483_CR53","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","volume":"11","author":"T Kawai","year":"2010","unstructured":"Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on toll-like receptors [J]. Nature Immunology 11(5):373","journal-title":"Nature Immunology"},{"key":"4483_CR54","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","volume":"21","author":"K Takeda","year":"2003","unstructured":"Takeda K, Kaisho T, Akira S (2003) Toll-like receptors. Annu Rev Immunol 21:335\u2013376","journal-title":"Annu Rev Immunol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04483-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04483-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04483-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T10:07:11Z","timestamp":1741082831000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04483-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,17]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["4483"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04483-z","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,17]]},"assertion":[{"value":"3 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Animal Care and Use Committee of Nantong University approved all the protocols that were used in this study. All the animal tests were conducted according to the Key Laboratory of Neuroregeneration Guidelines for the Care and Use of Laboratory Animals and the National Institutes of Health\u2019s Guide for the Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Consent to Participate"}},{"value":"All the authors of this manuscript have approved the manuscript and consented to its publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was approved by the Institutional Animal Care and Use Committee of Nantong University (Approval No. 2019-nsfc004) on March 1, 2019.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional Review Board Statement"}},{"value":"The Copyright License Agreement was signed by all the authors before publication.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Copyright License Agreement"}}]}}