{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:52:01Z","timestamp":1791492721092,"version":"4.3.4"},"reference-count":148,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s12035-024-04485-x","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T19:02:34Z","timestamp":1726513354000},"page":"3361-3375","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["PSD-95 Protein: A Promising Therapeutic Target in Chronic Pain"],"prefix":"10.1007","volume":"62","author":[{"given":"Lulin","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4619-9441","authenticated-orcid":false,"given":"Song","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"issue":"36","key":"4485_CR1","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.15585\/mmwr.mm6736a2","volume":"67","author":"J Dahlhamer","year":"2018","unstructured":"Dahlhamer J, Lucas J, Zelaya C, Nahin R, Mackey S, DeBar L, Kerns R, Korff M (2018) Prevalence of chronic pain and high-impact chronic pain among adults - United States, 2016. MMWR Morb Mortal Wkly Rep 67(36):1001\u20131006. https:\/\/doi.org\/10.15585\/mmwr.mm6736a2","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"10289","key":"4485_CR2","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1016\/s0140-6736(21)00393-7","volume":"397","author":"SP Cohen","year":"2021","unstructured":"Cohen SP, Vase L, Hooten WM (2021) Chronic pain: an update on burden, best practices, and new advances. Lancet (London, England) 397(10289):2082\u20132097. https:\/\/doi.org\/10.1016\/s0140-6736(21)00393-7","journal-title":"Lancet (London, England)"},{"issue":"8","key":"4485_CR3","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1097\/j.pain.0000000000001575","volume":"160","author":"K Boersma","year":"2019","unstructured":"Boersma K, S\u00f6dermark M, Hesser H, Flink IK, Gerdle B, Linton SJ (2019) Efficacy of a transdiagnostic emotion-focused exposure treatment for chronic pain patients with comorbid anxiety and depression: a randomized controlled trial. Pain 160(8):1708\u20131718. https:\/\/doi.org\/10.1097\/j.pain.0000000000001575","journal-title":"Pain"},{"issue":"6","key":"4485_CR4","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.janxdis.2009.03.003","volume":"23","author":"RN Carleton","year":"2009","unstructured":"Carleton RN, Abrams MP, Asmundson GJ, Antony MM, McCabe RE (2009) Pain-related anxiety and anxiety sensitivity across anxiety and depressive disorders. J Anxiety Disord 23(6):791\u2013798. https:\/\/doi.org\/10.1016\/j.janxdis.2009.03.003","journal-title":"J Anxiety Disord"},{"issue":"7","key":"4485_CR5","doi-asserted-by":"publisher","first-page":"e812","DOI":"10.1097\/j.pain.0000000000002497","volume":"163","author":"T Miettinen","year":"2022","unstructured":"Miettinen T, Sverloff J, Lappalainen OP, Linton SJ, Sipil\u00e4 K, Kalso E (2022) Sleep problems in pain patients entering tertiary pain care: the role of pain-related anxiety, medication use, self-reported diseases, and sleep disorders. Pain 163(7):e812\u2013e820. https:\/\/doi.org\/10.1097\/j.pain.0000000000002497","journal-title":"Pain"},{"issue":"5","key":"4485_CR6","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1002\/ejp.1003","volume":"21","author":"A Malfliet","year":"2017","unstructured":"Malfliet A, Coppieters I, Van Wilgen P, Kregel J, De Pauw R, Dolphens M, Ickmans K (2017) Brain changes associated with cognitive and emotional factors in chronic pain: a systematic review. European J Pain (London, England) 21(5):769\u2013786. https:\/\/doi.org\/10.1002\/ejp.1003","journal-title":"European J Pain (London, England)"},{"issue":"8","key":"4485_CR7","doi-asserted-by":"publisher","first-page":"e2113401","DOI":"10.1001\/jamanetworkopen.2021.13401","volume":"4","author":"BD Darnall","year":"2021","unstructured":"Darnall BD, Roy A, Chen AL, Ziadni MS, Keane RT, You DS, Slater K, Poupore-King H et al (2021) Comparison of a single-session pain management skills intervention with a single-session health education intervention and 8 sessions of cognitive behavioral therapy in adults with chronic low back pain: a randomized clinical trial. JAMA Netw Open 4(8):e2113401. https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.13401","journal-title":"JAMA Netw Open"},{"issue":"10","key":"4485_CR8","doi-asserted-by":"publisher","first-page":"e1041","DOI":"10.1097\/j.pain.0000000000002606","volume":"163","author":"M Gandy","year":"2022","unstructured":"Gandy M, Pang STY, Scott AJ, Heriseanu AI, Bisby MA, Dudeney J, Karin E, Titov N et al (2022) Internet-delivered cognitive and behavioural based interventions for adults with chronic pain: a systematic review and meta-analysis of randomized controlled trials. Pain 163(10):e1041\u2013e1053. https:\/\/doi.org\/10.1097\/j.pain.0000000000002606","journal-title":"Pain"},{"issue":"1","key":"4485_CR9","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s10194-017-0779-1","volume":"18","author":"SH Lee","year":"2017","unstructured":"Lee SH, Kang Y, Cho SJ (2017) Subjective cognitive decline in patients with migraine and its relationship with depression, anxiety, and sleep quality. J Headache Pain 18(1):77. https:\/\/doi.org\/10.1186\/s10194-017-0779-1","journal-title":"J Headache Pain"},{"issue":"3","key":"4485_CR10","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/s2468-1253(18)30008-6","volume":"3","author":"AD Farmer","year":"2018","unstructured":"Farmer AD, Holt CB, Downes TJ, Ruggeri E, Del Vecchio S, De Giorgio R (2018) Pathophysiology, diagnosis, and management of opioid-induced constipation. Lancet Gastroenterol Hepatol 3(3):203\u2013212. https:\/\/doi.org\/10.1016\/s2468-1253(18)30008-6","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"14","key":"4485_CR11","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1111\/bph.13809","volume":"175","author":"T G\u00fcnther","year":"2018","unstructured":"G\u00fcnther T, Dasgupta P, Mann A, Miess E, Kliewer A, Fritzwanker S, Steinborn R, Schulz S (2018) Targeting multiple opioid receptors - improved analgesics with reduced side effects? Br J Pharmacol 175(14):2857\u20132868. https:\/\/doi.org\/10.1111\/bph.13809","journal-title":"Br J Pharmacol"},{"key":"4485_CR12","doi-asserted-by":"publisher","first-page":"114147","DOI":"10.1016\/j.bcp.2020.114147","volume":"180","author":"S Bindu","year":"2020","unstructured":"Bindu S, Mazumder S, Bandyopadhyay U (2020) Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective. Biochem Pharmacol 180:114147. https:\/\/doi.org\/10.1016\/j.bcp.2020.114147","journal-title":"Biochem Pharmacol"},{"issue":"8","key":"4485_CR13","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.tips.2017.05.008","volume":"38","author":"T Grosser","year":"2017","unstructured":"Grosser T, Ricciotti E, FitzGerald GA (2017) The cardiovascular pharmacology of nonsteroidal anti-inflammatory drugs. Trends Pharmacol Sci 38(8):733\u2013748. https:\/\/doi.org\/10.1016\/j.tips.2017.05.008","journal-title":"Trends Pharmacol Sci"},{"issue":"2","key":"4485_CR14","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/nrn2540","volume":"10","author":"W Feng","year":"2009","unstructured":"Feng W, Zhang M (2009) Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density. Nat Rev Neurosci 10(2):87\u201399. https:\/\/doi.org\/10.1038\/nrn2540","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"4485_CR15","doi-asserted-by":"publisher","first-page":"17114","DOI":"10.1038\/s41598-022-21488-7","volume":"12","author":"A Li","year":"2022","unstructured":"Li A, Huang CJ, Gu KP, Huang Y, Huang YQ, Zhang H, Lin JP, Liu YF et al (2022) PSD-95 in the anterior cingulate cortex contributes to neuropathic pain by interdependent activation with NR2B. Sci Rep 12(1):17114. https:\/\/doi.org\/10.1038\/s41598-022-21488-7","journal-title":"Sci Rep"},{"key":"4485_CR16","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.bbi.2022.05.014","volume":"104","author":"L Liu","year":"2022","unstructured":"Liu L, Dai L, Xu D, Wang Y, Bai L, Chen X, Li M, Yang S et al (2022) Astrocyte secretes IL-6 to modulate PSD-95 palmitoylation in basolateral amygdala and depression-like behaviors induced by peripheral nerve injury. Brain Behav Immun 104:139\u2013154. https:\/\/doi.org\/10.1016\/j.bbi.2022.05.014","journal-title":"Brain Behav Immun"},{"issue":"7","key":"4485_CR17","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1093\/jnen\/nlaa035","volume":"79","author":"YB Zhu","year":"2020","unstructured":"Zhu YB, Jia GL, Wang JW, Ye XY, Lu JH, Chen JL, Zhang MB, Xie CS et al (2020) Activation of CaMKII and GluR1 by the PSD-95-GluN2B coupling-dependent phosphorylation of GluN2B in the spinal cord in a rat model of type-2 diabetic neuropathic pain. J Neuropathol Exp Neurol 79(7):800\u2013808. https:\/\/doi.org\/10.1093\/jnen\/nlaa035","journal-title":"J Neuropathol Exp Neurol"},{"issue":"10","key":"4485_CR18","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1038\/mt.2011.42","volume":"19","author":"R D\u2019Mello","year":"2011","unstructured":"D\u2019Mello R, Marchand F, Pezet S, McMahon SB, Dickenson AH (2011) Perturbing PSD-95 interactions with NR2B-subtype receptors attenuates spinal nociceptive plasticity and neuropathic pain. Mol Ther: J Am Soc Gene Ther 19(10):1780\u20131792. https:\/\/doi.org\/10.1038\/mt.2011.42","journal-title":"Mol Ther: J Am Soc Gene Ther"},{"key":"4485_CR19","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.neuropharm.2018.09.003","volume":"141","author":"W Cai","year":"2018","unstructured":"Cai W, Wu S, Pan Z, Xiao J, Li F, Cao J, Zang W, Tao YX (2018) Disrupting interaction of PSD-95 with nNOS attenuates hemorrhage-induced thalamic pain. Neuropharmacology 141:238\u2013248. https:\/\/doi.org\/10.1016\/j.neuropharm.2018.09.003","journal-title":"Neuropharmacology"},{"issue":"1","key":"4485_CR20","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s10194-021-01299-3","volume":"22","author":"Y Wang","year":"2021","unstructured":"Wang Y, Pan Q, Tian R, Wen Q, Qin G, Zhang D, Chen L, Zhang Y et al (2021) Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model. J Headache Pain 22(1):84. https:\/\/doi.org\/10.1186\/s10194-021-01299-3","journal-title":"J Headache Pain"},{"issue":"24","key":"4485_CR21","doi-asserted-by":"publisher","first-page":"21697","DOI":"10.1074\/jbc.M112339200","volume":"277","author":"IA Lim","year":"2002","unstructured":"Lim IA, Hall DD, Hell JW (2002) Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. J Biol Chem 277(24):21697\u201321711. https:\/\/doi.org\/10.1074\/jbc.M112339200","journal-title":"J Biol Chem"},{"issue":"12","key":"4485_CR22","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1038\/nrd1578","volume":"3","author":"KK Dev","year":"2004","unstructured":"Dev KK (2004) Making protein interactions druggable: targeting PDZ domains. Nat Rev Drug Discovery 3(12):1047\u20131056. https:\/\/doi.org\/10.1038\/nrd1578","journal-title":"Nat Rev Drug Discovery"},{"issue":"10","key":"4485_CR23","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nrn1517","volume":"5","author":"E Kim","year":"2004","unstructured":"Kim E, Sheng M (2004) PDZ domain proteins of synapses. Nat Rev Neurosci 5(10):771\u2013781. https:\/\/doi.org\/10.1038\/nrn1517","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"4485_CR24","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1083\/jcb.136.3.669","volume":"136","author":"E Kim","year":"1997","unstructured":"Kim E, Naisbitt S, Hsueh YP, Rao A, Rothschild A, Craig AM, Sheng M (1997) GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95\/SAP90 family of channel clustering molecules. J Cell Biol 136(3):669\u2013678. https:\/\/doi.org\/10.1083\/jcb.136.3.669","journal-title":"J Cell Biol"},{"issue":"1","key":"4485_CR25","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/s0896-6273(00)00013-1","volume":"27","author":"M Colledge","year":"2000","unstructured":"Colledge M, Dean RA, Scott GK, Langeberg LK, Huganir RL, Scott JD (2000) Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Neuron 27(1):107\u2013119. https:\/\/doi.org\/10.1016\/s0896-6273(00)00013-1","journal-title":"Neuron"},{"issue":"2","key":"4485_CR26","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/s0896-6273(01)00355-5","volume":"31","author":"DT Pak","year":"2001","unstructured":"Pak DT, Yang S, Rudolph-Correia S, Kim E, Sheng M (2001) Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron 31(2):289\u2013303. https:\/\/doi.org\/10.1016\/s0896-6273(01)00355-5","journal-title":"Neuron"},{"issue":"5231","key":"4485_CR27","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1126\/science.7569905","volume":"269","author":"HC Kornau","year":"1995","unstructured":"Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995) Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science (New York, NY) 269(5231):1737\u20131740. https:\/\/doi.org\/10.1126\/science.7569905","journal-title":"Science (New York, NY)"},{"issue":"6552","key":"4485_CR28","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/378085a0","volume":"378","author":"E Kim","year":"1995","unstructured":"Kim E, Niethammer M, Rothschild A, Jan YN, Sheng M (1995) Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Nature 378(6552):85\u201388. https:\/\/doi.org\/10.1038\/378085a0","journal-title":"Nature"},{"issue":"5","key":"4485_CR29","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/s0092-8674(00)81053-3","volume":"84","author":"JE Brenman","year":"1996","unstructured":"Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F et al (1996) Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell 84(5):757\u2013767. https:\/\/doi.org\/10.1016\/s0092-8674(00)81053-3","journal-title":"Cell"},{"issue":"4","key":"4485_CR30","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/s0896-6273(00)81009-0","volume":"20","author":"M Niethammer","year":"1998","unstructured":"Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M (1998) CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95\/SAP90. Neuron 20(4):693\u2013707. https:\/\/doi.org\/10.1016\/s0896-6273(00)81009-0","journal-title":"Neuron"},{"issue":"1633","key":"4485_CR31","doi-asserted-by":"publisher","first-page":"20130134","DOI":"10.1098\/rstb.2013.0134","volume":"369","author":"CE Taft","year":"2014","unstructured":"Taft CE, Turrigiano GG (2014) PSD-95 promotes the stabilization of young synaptic contacts. Philos Trans R Soc Lond B Biol Sci 369(1633):20130134. https:\/\/doi.org\/10.1098\/rstb.2013.0134","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"5","key":"4485_CR32","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.neuron.2008.10.014","volume":"60","author":"P Steiner","year":"2008","unstructured":"Steiner P, Higley MJ, Xu W, Czervionke BL, Malenka RC, Sabatini BL (2008) Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity. Neuron 60(5):788\u2013802. https:\/\/doi.org\/10.1016\/j.neuron.2008.10.014","journal-title":"Neuron"},{"issue":"12","key":"4485_CR33","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1038\/nm.2245","volume":"16","author":"L Zhou","year":"2010","unstructured":"Zhou L, Li F, Xu HB, Luo CX, Wu HY, Zhu MM, Lu W, Ji X et al (2010) Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med 16(12):1439\u20131443. https:\/\/doi.org\/10.1038\/nm.2245","journal-title":"Nat Med"},{"issue":"24","key":"4485_CR34","doi-asserted-by":"publisher","first-page":"21901","DOI":"10.1074\/jbc.M301905200","volume":"278","author":"Z Xia","year":"2003","unstructured":"Xia Z, Gray JA, Compton-Toth BA, Roth BL (2003) A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction. J Biol Chem 278(24):21901\u201321908. https:\/\/doi.org\/10.1074\/jbc.M301905200","journal-title":"J Biol Chem"},{"issue":"46","key":"4485_CR35","doi-asserted-by":"publisher","first-page":"19575","DOI":"10.1073\/pnas.0905884106","volume":"106","author":"KA Jones","year":"2009","unstructured":"Jones KA, Srivastava DP, Allen JA, Strachan RT, Roth BL, Penzes P (2009) Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling. Proc Natl Acad Sci USA 106(46):19575\u201319580. https:\/\/doi.org\/10.1073\/pnas.0905884106","journal-title":"Proc Natl Acad Sci USA"},{"issue":"22","key":"4485_CR36","doi-asserted-by":"publisher","first-page":"7124","DOI":"10.1523\/jneurosci.1090-09.2009","volume":"29","author":"AI Abbas","year":"2009","unstructured":"Abbas AI, Yadav PN, Yao WD, Arbuckle MI, Grant SG, Caron MG, Roth BL (2009) PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. J Neurosci: Off J Soc Neurosci 29(22):7124\u20137136. https:\/\/doi.org\/10.1523\/jneurosci.1090-09.2009","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"2","key":"4485_CR37","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.pharmthera.2011.11.005","volume":"133","author":"MV Doucet","year":"2012","unstructured":"Doucet MV, Harkin A, Dev KK (2012) The PSD-95\/nNOS complex: new drugs for depression? Pharmacol Ther 133(2):218\u2013229. https:\/\/doi.org\/10.1016\/j.pharmthera.2011.11.005","journal-title":"Pharmacol Ther"},{"issue":"40","key":"4485_CR38","doi-asserted-by":"publisher","first-page":"13535","DOI":"10.1523\/jneurosci.1305-14.2014","volume":"34","author":"CX Luo","year":"2014","unstructured":"Luo CX, Lin YH, Qian XD, Tang Y, Zhou HH, Jin X, Ni HY, Zhang FY et al (2014) Interaction of nNOS with PSD-95 negatively controls regenerative repair after stroke. J Neurosci: Off J Soc Neurosci 34(40):13535\u201313548. https:\/\/doi.org\/10.1523\/jneurosci.1305-14.2014","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"6","key":"4485_CR39","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/nn1903","volume":"10","author":"A Yoshii","year":"2007","unstructured":"Yoshii A, Constantine-Paton M (2007) BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation. Nat Neurosci 10(6):702\u2013711. https:\/\/doi.org\/10.1038\/nn1903","journal-title":"Nat Neurosci"},{"issue":"834","key":"4485_CR40","doi-asserted-by":"publisher","first-page":"eadn4556","DOI":"10.1126\/scisignal.adn4556","volume":"17","author":"X Shi","year":"2024","unstructured":"Shi X, Zhou XZ, Chen G, Luo WF, Zhou C, He TJ, Naik MT, Jiang Q et al (2024) Targeting the postsynaptic scaffolding protein PSD-95 enhances BDNF signaling to mitigate depression-like behaviors in mice. Sci Signal 17(834):eadn4556. https:\/\/doi.org\/10.1126\/scisignal.adn4556","journal-title":"Sci Signal"},{"issue":"1\u20132","key":"4485_CR41","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.cell.2015.11.034","volume":"164","author":"SK Singh","year":"2016","unstructured":"Singh SK, Stogsdill JA, Pulimood NS, Dingsdale H, Kim YH, Pilaz LJ, Kim IH, Manhaes AC et al (2016) Astrocytes assemble thalamocortical synapses by bridging NRX1\u03b1 and NL1 via Hevin. Cell 164(1\u20132):183\u2013196. https:\/\/doi.org\/10.1016\/j.cell.2015.11.034","journal-title":"Cell"},{"key":"4485_CR42","doi-asserted-by":"crossref","unstructured":"Lin TB, Lai CY, Hsieh MC, Jiang JL, Cheng JK, Chau YP, Ruan T, Chen GD et al (2015) Neuropathic allodynia involves spinal neurexin-1\u03b2-dependent neuroligin-1\/postsynaptic density-95\/NR2B cascade in rats. 123(4):909","DOI":"10.1097\/ALN.0000000000000809"},{"issue":"6","key":"4485_CR43","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1007\/bf02977638","volume":"30","author":"HJ Kim","year":"2007","unstructured":"Kim HJ, Han AM, Shim JH, Yoon HH, Kwon H, Kwon YK (2007) Shp2 is involved in neuronal differentiation of hippocampal precursor cells. Arch Pharmacal Res 30(6):750\u2013754. https:\/\/doi.org\/10.1007\/bf02977638","journal-title":"Arch Pharmacal Res"},{"issue":"5","key":"4485_CR44","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.pain.2012.02.006","volume":"153","author":"HY Peng","year":"2012","unstructured":"Peng HY, Chen GD, Lai CY, Hsieh MC, Lin TB (2012) Spinal SIRP\u03b11-SHP2 interaction regulates spinal nerve ligation-induced neuropathic pain via PSD-95-dependent NR2B activation in rats. Pain 153(5):1042\u20131053. https:\/\/doi.org\/10.1016\/j.pain.2012.02.006","journal-title":"Pain"},{"issue":"5","key":"4485_CR45","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.neuron.2007.01.030","volume":"53","author":"C Bats","year":"2007","unstructured":"Bats C, Groc L, Choquet D (2007) The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking. Neuron 53(5):719\u2013734. https:\/\/doi.org\/10.1016\/j.neuron.2007.01.030","journal-title":"Neuron"},{"issue":"33","key":"4485_CR46","doi-asserted-by":"publisher","first-page":"12029","DOI":"10.1523\/jneurosci.2388-11.2011","volume":"31","author":"MJ Bianchetta","year":"2011","unstructured":"Bianchetta MJ, Lam TT, Jones SN, Morabito MA (2011) Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons. J Neurosci: Off J Soc Neurosci 31(33):12029\u201312035. https:\/\/doi.org\/10.1523\/jneurosci.2388-11.2011","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"2","key":"4485_CR47","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.neuron.2007.11.027","volume":"57","author":"W Xu","year":"2008","unstructured":"Xu W, Schl\u00fcter OM, Steiner P, Czervionke BL, Sabatini B, Malenka RC (2008) Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD. Neuron 57(2):248\u2013262. https:\/\/doi.org\/10.1016\/j.neuron.2007.11.027","journal-title":"Neuron"},{"issue":"2","key":"4485_CR48","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/nn.2249","volume":"12","author":"S Bhattacharyya","year":"2009","unstructured":"Bhattacharyya S, Biou V, Xu W, Schl\u00fcter O, Malenka RC (2009) A critical role for PSD-95\/AKAP interactions in endocytosis of synaptic AMPA receptors. Nat Neurosci 12(2):172\u2013181. https:\/\/doi.org\/10.1038\/nn.2249","journal-title":"Nat Neurosci"},{"key":"4485_CR49","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.pneurobio.2013.10.003","volume":"112","author":"MV Caldeira","year":"2014","unstructured":"Caldeira MV, Salazar IL, Curcio M, Canzoniero LM, Duarte CB (2014) Role of the ubiquitin-proteasome system in brain ischemia: friend or foe? Prog Neurobiol 112:50\u201369. https:\/\/doi.org\/10.1016\/j.pneurobio.2013.10.003","journal-title":"Prog Neurobiol"},{"issue":"6","key":"4485_CR50","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/s0092-8674(02)00683-9","volume":"108","author":"D El-Husseini Ael","year":"2002","unstructured":"El-Husseini Ael D, Schnell E, Dakoji S, Sweeney N, Zhou Q, Prange O, Gauthier-Campbell C, Aguilera-Moreno A et al (2002) Synaptic strength regulated by palmitate cycling on PSD-95. Cell 108(6):849\u2013863. https:\/\/doi.org\/10.1016\/s0092-8674(02)00683-9","journal-title":"Cell"},{"issue":"6","key":"4485_CR51","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.neuron.2004.12.005","volume":"44","author":"M Fukata","year":"2004","unstructured":"Fukata M, Fukata Y, Adesnik H, Nicoll RA, Bredt DS (2004) Identification of PSD-95 palmitoylating enzymes. Neuron 44(6):987\u2013996. https:\/\/doi.org\/10.1016\/j.neuron.2004.12.005","journal-title":"Neuron"},{"issue":"3","key":"4485_CR52","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.neuron.2007.09.007","volume":"56","author":"MJ Kim","year":"2007","unstructured":"Kim MJ, Futai K, Jo J, Hayashi Y, Cho K, Sheng M (2007) Synaptic accumulation of PSD-95 and synaptic function regulated by phosphorylation of serine-295 of PSD-95. Neuron 56(3):488\u2013502. https:\/\/doi.org\/10.1016\/j.neuron.2007.09.007","journal-title":"Neuron"},{"issue":"2","key":"4485_CR53","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/nn.3912","volume":"18","author":"AM Vogl","year":"2015","unstructured":"Vogl AM, Brockmann MM, Giusti SA, Maccarrone G, Vercelli CA, Bauder CA, Richter JS, Roselli F et al (2015) Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition. Nat Neurosci 18(2):239\u2013251. https:\/\/doi.org\/10.1038\/nn.3912","journal-title":"Nat Neurosci"},{"issue":"1","key":"4485_CR54","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.neuron.2011.05.033","volume":"71","author":"GP Ho","year":"2011","unstructured":"Ho GP, Selvakumar B, Mukai J, Hester LD, Wang Y, Gogos JA, Snyder SH (2011) S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Neuron 71(1):131\u2013141. https:\/\/doi.org\/10.1016\/j.neuron.2011.05.033","journal-title":"Neuron"},{"issue":"1","key":"4485_CR55","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nrn.2016.162","volume":"18","author":"R Kuner","year":"2016","unstructured":"Kuner R, Flor H (2016) Structural plasticity and reorganisation in chronic pain. Nat Rev Neurosci 18(1):20\u201330. https:\/\/doi.org\/10.1038\/nrn.2016.162","journal-title":"Nat Rev Neurosci"},{"issue":"8","key":"4485_CR56","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/nrn.2016.68","volume":"17","author":"TV Bliss","year":"2016","unstructured":"Bliss TV, Collingridge GL, Kaang BK, Zhuo M (2016) Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain. Nat Rev Neurosci 17(8):485\u2013496. https:\/\/doi.org\/10.1038\/nrn.2016.68","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"4485_CR57","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.tins.2014.04.002","volume":"37","author":"C Luo","year":"2014","unstructured":"Luo C, Kuner T, Kuner R (2014) Synaptic plasticity in pathological pain. Trends Neurosci 37(6):343\u2013355. https:\/\/doi.org\/10.1016\/j.tins.2014.04.002","journal-title":"Trends Neurosci"},{"issue":"1","key":"4485_CR58","doi-asserted-by":"publisher","first-page":"9486","DOI":"10.1038\/s41598-019-45971-w","volume":"9","author":"AA Coley","year":"2019","unstructured":"Coley AA, Gao WJ (2019) PSD-95 deficiency disrupts PFC-associated function and behavior during neurodevelopment. Sci Rep 9(1):9486. https:\/\/doi.org\/10.1038\/s41598-019-45971-w","journal-title":"Sci Rep"},{"key":"4485_CR59","doi-asserted-by":"publisher","first-page":"108277","DOI":"10.1016\/j.neuropharm.2020.108277","volume":"179","author":"EP McEachern","year":"2020","unstructured":"McEachern EP, Coley AA, Yang SS, Gao WJ (2020) PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex. Neuropharmacology 179:108277. https:\/\/doi.org\/10.1016\/j.neuropharm.2020.108277","journal-title":"Neuropharmacology"},{"issue":"9","key":"4485_CR60","doi-asserted-by":"publisher","first-page":"e1233","DOI":"10.1038\/tp.2017.205","volume":"7","author":"M Notaras","year":"2017","unstructured":"Notaras M, Du X, Gogos J, van den Buuse M, Hill RA (2017) The BDNF Val66Met polymorphism regulates glucocorticoid-induced corticohippocampal remodeling and behavioral despair. Transl Psychiatry 7(9):e1233. https:\/\/doi.org\/10.1038\/tp.2017.205","journal-title":"Transl Psychiatry"},{"issue":"8","key":"4485_CR61","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/sj.mp.4001844","volume":"11","author":"LV Kristiansen","year":"2006","unstructured":"Kristiansen LV, Beneyto M, Haroutunian V, Meador-Woodruff JH (2006) Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia. Mol Psychiatry 11(8):737-747,705. https:\/\/doi.org\/10.1038\/sj.mp.4001844","journal-title":"Mol Psychiatry"},{"issue":"4","key":"4485_CR62","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1038\/npp.2011.267","volume":"37","author":"AJ Funk","year":"2012","unstructured":"Funk AJ, McCullumsmith RE, Haroutunian V, Meador-Woodruff JH (2012) Abnormal activity of the MAPK- and cAMP-associated signaling pathways in frontal cortical areas in postmortem brain in schizophrenia. Neuropsychopharmacol\u202f: Off Public Am College Neuropsychopharmacol 37(4):896\u2013905. https:\/\/doi.org\/10.1038\/npp.2011.267","journal-title":"Neuropsychopharmacol : Off Public Am College Neuropsychopharmacol"},{"issue":"3","key":"4485_CR63","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.jad.2012.01.013","volume":"138","author":"J Zhao","year":"2012","unstructured":"Zhao J, Bao AM, Qi XR, Kamphuis W, Luchetti S, Lou JS, Swaab DF (2012) Gene expression of GABA and glutamate pathway markers in the prefrontal cortex of non-suicidal elderly depressed patients. J Affect Disord 138(3):494\u2013502. https:\/\/doi.org\/10.1016\/j.jad.2012.01.013","journal-title":"J Affect Disord"},{"issue":"2","key":"4485_CR64","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1017\/s1461145708008985","volume":"12","author":"B Karolewicz","year":"2009","unstructured":"Karolewicz B, Szebeni K, Gilmore T, Maciag D, Stockmeier CA, Ordway GA (2009) Elevated levels of NR2A and PSD-95 in the lateral amygdala in depression. Int J Neuropsychopharmacol 12(2):143\u2013153. https:\/\/doi.org\/10.1017\/s1461145708008985","journal-title":"Int J Neuropsychopharmacol"},{"issue":"1","key":"4485_CR65","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41398-018-0352-y","volume":"9","author":"E Montalban","year":"2019","unstructured":"Montalban E, Al-Massadi O, Sancho-Balsells A, Brito V, de Pins B, Alberch J, Gin\u00e9s S, Girault JA et al (2019) Pyk2 in the amygdala modulates chronic stress sequelae via PSD-95-related micro-structural changes. Transl Psychiatry 9(1):3. https:\/\/doi.org\/10.1038\/s41398-018-0352-y","journal-title":"Transl Psychiatry"},{"issue":"12","key":"4485_CR66","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1176\/appi.ajp.2010.10040484","volume":"167","author":"M Feyder","year":"2010","unstructured":"Feyder M, Karlsson RM, Mathur P, Lyman M, Bock R, Momenan R, Munasinghe J, Scattoni ML et al (2010) Association of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams\u2019 syndrome. Am J Psychiatry 167(12):1508\u20131517. https:\/\/doi.org\/10.1176\/appi.ajp.2010.10040484","journal-title":"Am J Psychiatry"},{"issue":"3","key":"4485_CR67","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.biopsych.2010.09.037","volume":"69","author":"A Okvist","year":"2011","unstructured":"Okvist A, Fagergren P, Whittard J, Garcia-Osta A, Drakenberg K, Horvath MC, Schmidt CJ, Keller E et al (2011) Dysregulated postsynaptic density and endocytic zone in the amygdala of human heroin and cocaine abusers. Biol Psychiat 69(3):245\u2013252. https:\/\/doi.org\/10.1016\/j.biopsych.2010.09.037","journal-title":"Biol Psychiat"},{"issue":"1","key":"4485_CR68","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1523\/jneurosci.19-01-00096.1999","volume":"19","author":"W Zhang","year":"1999","unstructured":"Zhang W, Vazquez L, Apperson M, Kennedy MB (1999) Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus. J Neurosci: Off J Soc Neurosci 19(1):96\u2013108. https:\/\/doi.org\/10.1523\/jneurosci.19-01-00096.1999","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"10","key":"4485_CR69","doi-asserted-by":"publisher","first-page":"6786","DOI":"10.1007\/s12035-015-9597-0","volume":"53","author":"H Yu","year":"2016","unstructured":"Yu H, Liao Y, Li T, Cui Y, Wang G, Zhao F, Jin Y (2016) Alterations of synaptic proteins in the hippocampus of mouse offspring induced by developmental lead exposure. Mol Neurobiol 53(10):6786\u20136798. https:\/\/doi.org\/10.1007\/s12035-015-9597-0","journal-title":"Mol Neurobiol"},{"issue":"6","key":"4485_CR70","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.3171\/2010.3.Jns091212","volume":"113","author":"C Wakade","year":"2010","unstructured":"Wakade C, Sukumari-Ramesh S, Laird MD, Dhandapani KM, Vender JR (2010) Delayed reduction in hippocampal postsynaptic density protein-95 expression temporally correlates with cognitive dysfunction following controlled cortical impact in mice. J Neurosurg 113(6):1195\u20131201. https:\/\/doi.org\/10.3171\/2010.3.Jns091212","journal-title":"J Neurosurg"},{"issue":"2","key":"4485_CR71","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1152\/physrev.00056.2021","volume":"103","author":"NP Rasiah","year":"2023","unstructured":"Rasiah NP, Loewen SP, Bains JS (2023) Windows into stress: a glimpse at emerging roles for CRH(PVN) neurons. Physiol Rev 103(2):1667\u20131691. https:\/\/doi.org\/10.1152\/physrev.00056.2021","journal-title":"Physiol Rev"},{"issue":"15","key":"4485_CR72","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1523\/jneurosci.1766-22.2023","volume":"43","author":"G Hou","year":"2023","unstructured":"Hou G, Jiang S, Chen G, Deng X, Li F, Xu H, Chen B, Zhu Y (2023) Opioid receptors modulate firing and synaptic transmission in the paraventricular nucleus of the thalamus. J Neurosci: Off J Soc Neurosci 43(15):2682\u20132695. https:\/\/doi.org\/10.1523\/jneurosci.1766-22.2023","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"12","key":"4485_CR73","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1097\/j.pain.0000000000000318","volume":"156","author":"A Jurik","year":"2015","unstructured":"Jurik A, Auffenberg E, Klein S, Deussing JM, Schmid RM, Wotjak CT, Thoeringer CK (2015) Roles of prefrontal cortex and paraventricular thalamus in affective and mechanical components of visceral nociception. Pain 156(12):2479\u20132491. https:\/\/doi.org\/10.1097\/j.pain.0000000000000318","journal-title":"Pain"},{"issue":"12","key":"4485_CR74","doi-asserted-by":"publisher","first-page":"5970","DOI":"10.7150\/thno.58364","volume":"11","author":"J Li","year":"2021","unstructured":"Li J, Zhang L, Xu C, Shen YY, Lin YH, Zhang Y, Wu HY, Chang L et al (2021) A pain killer without analgesic tolerance designed by co-targeting PSD-95-nNOS interaction and \u03b12-containning GABA(A)Rs. Theranostics 11(12):5970\u20135985. https:\/\/doi.org\/10.7150\/thno.58364","journal-title":"Theranostics"},{"issue":"7","key":"4485_CR75","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1080\/15548627.2024.2330038","volume":"20","author":"S Fu","year":"2024","unstructured":"Fu S, Sun H, Wang J, Gao S, Zhu L, Cui K, Liu S, Qi X et al (2024) Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain. Autophagy 20(7):1559\u20131576. https:\/\/doi.org\/10.1080\/15548627.2024.2330038","journal-title":"Autophagy"},{"key":"4485_CR76","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.bbi.2024.01.012","volume":"117","author":"XJ Lv","year":"2024","unstructured":"Lv XJ, Lv SS, Wang GH, Chang Y, Cai YQ, Liu HZ, Xu GZ, Xu WD et al (2024) Glia-derived adenosine in the ventral hippocampus drives pain-related anxiodepression in a mouse model resembling trigeminal neuralgia. Brain Behav Immun 117:224\u2013241. https:\/\/doi.org\/10.1016\/j.bbi.2024.01.012","journal-title":"Brain Behav Immun"},{"issue":"3","key":"4485_CR77","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/j.1365-2990.2007.00917.x","volume":"34","author":"C Cheng","year":"2008","unstructured":"Cheng C, Gao S, Zhao J, Niu S, Chen M, Li X, Qin J, Shi S et al (2008) Spatiotemporal patterns of postsynaptic density (PSD)-95 expression after rat spinal cord injury. Neuropathol Appl Neurobiol 34(3):340\u2013356. https:\/\/doi.org\/10.1111\/j.1365-2990.2007.00917.x","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"2","key":"4485_CR78","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.expneurol.2007.06.007","volume":"207","author":"M Nakano","year":"2007","unstructured":"Nakano M, Takagi N, Takagi K, Funakoshi H, Matsumoto K, Nakamura T, Takeo S (2007) Hepatocyte growth factor promotes the number of PSD-95 clusters in young hippocampal neurons. Exp Neurol 207(2):195\u2013202. https:\/\/doi.org\/10.1016\/j.expneurol.2007.06.007","journal-title":"Exp Neurol"},{"issue":"1","key":"4485_CR79","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/s41467-022-28429-y","volume":"13","author":"RG Xie","year":"2022","unstructured":"Xie RG, Chu WG, Liu DL, Wang X, Ma SB, Wang F, Wang FD, Lin Z et al (2022) Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain. Nat Commun 13(1):728. https:\/\/doi.org\/10.1038\/s41467-022-28429-y","journal-title":"Nat Commun"},{"issue":"13","key":"4485_CR80","doi-asserted-by":"publisher","first-page":"3844","DOI":"10.1016\/j.celrep.2019.05.087","volume":"27","author":"LJ Zhou","year":"2019","unstructured":"Zhou LJ, Peng J, Xu YN, Zeng WJ, Zhang J, Wei X, Mai CL, Lin ZJ et al (2019) Microglia are indispensable for synaptic plasticity in the spinal dorsal horn and chronic pain. Cell Rep 27(13):3844-3859.e3846. https:\/\/doi.org\/10.1016\/j.celrep.2019.05.087","journal-title":"Cell Rep"},{"issue":"3","key":"4485_CR81","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1007\/s12035-020-02180-1","volume":"58","author":"Y Liang","year":"2021","unstructured":"Liang Y, Ma Y, Wang J, Nie L, Hou X, Wu W, Zhang X, Tian Y (2021) Leptin contributes to neuropathic pain via extrasynaptic NMDAR-nNOS activation. Mol Neurobiol 58(3):1185\u20131195. https:\/\/doi.org\/10.1007\/s12035-020-02180-1","journal-title":"Mol Neurobiol"},{"issue":"1","key":"4485_CR82","doi-asserted-by":"publisher","first-page":"7848","DOI":"10.1038\/s41598-018-26209-7","volume":"8","author":"LE Huang","year":"2018","unstructured":"Huang LE, Guo SH, Thitiseranee L, Yang Y, Zhou YF, Yao YX (2018) N-methyl D-aspartate receptor subtype 2B antagonist, Ro 25\u20136981, attenuates neuropathic pain by inhibiting postsynaptic density 95 expression. Sci Rep 8(1):7848. https:\/\/doi.org\/10.1038\/s41598-018-26209-7","journal-title":"Sci Rep"},{"issue":"3","key":"4485_CR83","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/s0306-4522(02)00801-1","volume":"117","author":"F Tao","year":"2003","unstructured":"Tao F, Tao YX, Mao P, Johns RA (2003) Role of postsynaptic density protein-95 in the maintenance of peripheral nerve injury-induced neuropathic pain in rats. Neuroscience 117(3):731\u2013739. https:\/\/doi.org\/10.1016\/s0306-4522(02)00801-1","journal-title":"Neuroscience"},{"issue":"8","key":"4485_CR84","first-page":"4819","volume":"12","author":"JH Lu","year":"2020","unstructured":"Lu JH, Zhang MB, Wang JW, Ye XY, Chen JL, Jia GL, Xie CS, Shen YJ et al (2020) Kalirin-7 contributes to type 2 diabetic neuropathic pain via the postsynaptic density-95\/N-methyl-D-aspartate receptor 2B-dependent N-methyl-D-aspartate receptor 2B phosphorylation in the spinal cord in rats. Ame J Trans Res 12(8):4819\u20134829","journal-title":"Ame J Trans Res"},{"issue":"12","key":"4485_CR85","doi-asserted-by":"publisher","first-page":"5227","DOI":"10.1523\/jneurosci.4452-12.2013","volume":"33","author":"HY Peng","year":"2013","unstructured":"Peng HY, Chen GD, Lai CY, Hsieh MC, Lin TB (2013) Spinal serum-inducible and glucocorticoid-inducible kinase 1 mediates neuropathic pain via kalirin and downstream PSD-95-dependent NR2B phosphorylation in rats. J Neurosci: Off J Soc Neurosci 33(12):5227\u20135240. https:\/\/doi.org\/10.1523\/jneurosci.4452-12.2013","journal-title":"J Neurosci: Off J Soc Neurosci"},{"issue":"2","key":"4485_CR86","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1213\/ane.0000000000000279","volume":"119","author":"L Yang","year":"2014","unstructured":"Yang L, Xin X, Zhang J, Zhang L, Dong Y, Zhang Y, Mao J, Xie Z (2014) Inflammatory pain may induce cognitive impairment through an interlukin-6-dependent and postsynaptic density-95-associated mechanism. Anesth Analg 119(2):471\u2013480. https:\/\/doi.org\/10.1213\/ane.0000000000000279","journal-title":"Anesth Analg"},{"issue":"12","key":"4485_CR87","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1016\/j.pain.2014.09.012","volume":"155","author":"Z Aira","year":"2014","unstructured":"Aira Z, Barrenetxea T, Buesa I, G\u00f3mez-Esteban JC, Azkue JJ (2014) Synaptic upregulation and superadditive interaction of dopamine D2- and \u03bc-opioid receptors after peripheral nerve injury. Pain 155(12):2526\u20132533. https:\/\/doi.org\/10.1016\/j.pain.2014.09.012","journal-title":"Pain"},{"issue":"1","key":"4485_CR88","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.pain.2010.02.001","volume":"149","author":"G Miletic","year":"2010","unstructured":"Miletic G, Dumitrascu CI, Honstad CE, Micic D, Miletic V (2010) Loose ligation of the rat sciatic nerve elicits early accumulation of Shank1 protein in the post-synaptic density of spinal dorsal horn neurons. Pain 149(1):152\u2013159. https:\/\/doi.org\/10.1016\/j.pain.2010.02.001","journal-title":"Pain"},{"issue":"4","key":"4485_CR89","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/s0960-9822(03)00084-8","volume":"13","author":"EM Garry","year":"2003","unstructured":"Garry EM, Moss A, Delaney A, O\u2019Neill F, Blakemore J, Bowen J, Husi H, Mitchell R et al (2003) Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor\/CaM kinase II interactions are disrupted in PSD-95 mutant mice. Current Biology: CB 13(4):321\u2013328. https:\/\/doi.org\/10.1016\/s0960-9822(03)00084-8","journal-title":"Current Biology: CB"},{"issue":"8","key":"4485_CR90","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1038\/mt.2010.101","volume":"18","author":"X Pichon","year":"2010","unstructured":"Pichon X, Wattiez AS, Becamel C, Ehrlich I, Bockaert J, Eschalier A, Marin P, Courteix C (2010) Disrupting 5-HT(2A) receptor\/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain. Mol Ther: J Am Soc Gene Ther 18(8):1462\u20131470. https:\/\/doi.org\/10.1038\/mt.2010.101","journal-title":"Mol Ther: J Am Soc Gene Ther"},{"issue":"2","key":"4485_CR91","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.neuroscience.2010.02.031","volume":"167","author":"BW LeBlanc","year":"2010","unstructured":"LeBlanc BW, Iwata M, Mallon AP, Rupasinghe CN, Goebel DJ, Marshall J, Spaller MR, Saab CY (2010) A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia. Neuroscience 167(2):490\u2013500. https:\/\/doi.org\/10.1016\/j.neuroscience.2010.02.031","journal-title":"Neuroscience"},{"key":"4485_CR92","doi-asserted-by":"publisher","first-page":"173266","DOI":"10.1016\/j.ejphar.2020.173266","volume":"882","author":"R Wang","year":"2020","unstructured":"Wang R, Qiu Z, Wang G, Hu Q, Shi N, Zhang Z, Wu Y, Zhou C (2020) Quercetin attenuates diabetic neuropathic pain by inhibiting mTOR\/p70S6K pathway-mediated changes of synaptic morphology and synaptic protein levels in spinal dorsal horn of db\/db mice. Eur J Pharmacol 882:173266. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173266","journal-title":"Eur J Pharmacol"},{"key":"4485_CR93","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.expneurol.2018.09.014","volume":"311","author":"HH Zhou","year":"2019","unstructured":"Zhou HH, Zhang L, Zhang HX, Xu BR, Zhang JP, Zhou YJ, Qian XP, Ge WH (2019) Tat-HA-NR2B9c attenuate oxaliplatin-induced neuropathic pain. Exp Neurol 311:80\u201387. https:\/\/doi.org\/10.1016\/j.expneurol.2018.09.014","journal-title":"Exp Neurol"},{"issue":"5","key":"4485_CR94","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1097\/j.pain.0000000000001489","volume":"160","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, Ding X, Zhou Z, Qiu Z, Shi N, Zhou S, Du L, Zhu X et al (2019) Sirtuin 1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons. Pain 160(5):1082\u20131092. https:\/\/doi.org\/10.1097\/j.pain.0000000000001489","journal-title":"Pain"},{"issue":"23","key":"4485_CR95","doi-asserted-by":"publisher","first-page":"13623","DOI":"10.1111\/jcmm.15707","volume":"24","author":"L Xu","year":"2020","unstructured":"Xu L, Feng Q, Deng H, Zhang X, Ni H, Yao M (2020) Neurexin-2 is a potential regulator of inflammatory pain in the spinal dorsal horn of rats. J Cell Mol Med 24(23):13623\u201313633. https:\/\/doi.org\/10.1111\/jcmm.15707","journal-title":"J Cell Mol Med"},{"issue":"5","key":"4485_CR96","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1038\/s41401-022-01024-z","volume":"44","author":"ZJ Chen","year":"2023","unstructured":"Chen ZJ, Su CW, Xiong S, Li T, Liang HY, Lin YH, Chang L, Wu HY et al (2023) Enhanced AMPAR-dependent synaptic transmission by S-nitrosylation in the vmPFC contributes to chronic inflammatory pain-induced persistent anxiety in mice. Acta Pharmacol Sin 44(5):954\u2013968. https:\/\/doi.org\/10.1038\/s41401-022-01024-z","journal-title":"Acta Pharmacol Sin"},{"key":"4485_CR97","doi-asserted-by":"publisher","first-page":"1078309","DOI":"10.3389\/fnmol.2022.1078309","volume":"15","author":"W Zheng","year":"2022","unstructured":"Zheng W, Huang X, Wang J, Gao F, Chai Z, Zeng J, Li S, Yu C (2022) The chronification mechanism of orofacial inflammatory pain: facilitation by GPER1 and microglia in the rostral ventral medulla. Front Mol Neurosci 15:1078309. https:\/\/doi.org\/10.3389\/fnmol.2022.1078309","journal-title":"Front Mol Neurosci"},{"issue":"11","key":"4485_CR98","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1038\/mt.2008.192","volume":"16","author":"F Tao","year":"2008","unstructured":"Tao F, Su Q, Johns RA (2008) Cell-permeable peptide Tat-PSD-95 PDZ2 inhibits chronic inflammatory pain behaviors in mice. Mol Ther: J Am Soc Gene Ther 16(11):1776\u20131782. https:\/\/doi.org\/10.1038\/mt.2008.192","journal-title":"Mol Ther: J Am Soc Gene Ther"},{"key":"4485_CR99","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.ejphar.2016.03.045","volume":"780","author":"JT Andreasen","year":"2016","unstructured":"Andreasen JT, Nasser A, Caballero-Puntiverio M, Sahlholt M, Bach A, Gynther M, Str\u00f8mgaard K, Pickering DS (2016) Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function. Eur J Pharmacol 780:166\u2013173. https:\/\/doi.org\/10.1016\/j.ejphar.2016.03.045","journal-title":"Eur J Pharmacol"},{"key":"4485_CR100","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.neuropharm.2012.11.006","volume":"67","author":"JT Andreasen","year":"2013","unstructured":"Andreasen JT, Bach A, Gynther M, Nasser A, Mogensen J, Str\u00f8mgaard K, Pickering DS (2013) UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: comparison with the NMDA receptor antagonist MK-801. Neuropharmacology 67:193\u2013200. https:\/\/doi.org\/10.1016\/j.neuropharm.2012.11.006","journal-title":"Neuropharmacology"},{"issue":"6","key":"4485_CR101","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1213\/ane.0000000000000202","volume":"118","author":"Y Liu","year":"2014","unstructured":"Liu Y, Cui X, Sun YE, Yang X, Ni K, Zhou Y, Ma Z, Gu X (2014) Intrathecal injection of the peptide myr-NR2B9c attenuates bone cancer pain via perturbing N-methyl-D-aspartate receptor-PSD-95 protein interactions in mice. Anesth Analg 118(6):1345\u20131354. https:\/\/doi.org\/10.1213\/ane.0000000000000202","journal-title":"Anesth Analg"},{"issue":"9","key":"4485_CR102","doi-asserted-by":"publisher","first-page":"E1094","DOI":"10.1152\/ajpendo.00235.2012","volume":"303","author":"HY Peng","year":"2012","unstructured":"Peng HY, Hsieh MC, Lai CY, Chen GD, Huang YP, Lin TB (2012) Glucocorticoid mediates water avoidance stress-sensitized colon-bladder cross-talk via RSK2\/PSD-95\/NR2B in rats. Am J Physiol Endocrinol Metab 303(9):E1094-1106. https:\/\/doi.org\/10.1152\/ajpendo.00235.2012","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"13","key":"4485_CR103","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1097\/wnr.0000000000000849","volume":"28","author":"F Xu","year":"2017","unstructured":"Xu F, Zhao X, Liu L, Song J, Zhu Y, Chu S, Shao X, Li X et al (2017) Perturbing NR2B-PSD-95 interaction relieves neuropathic pain by inactivating CaMKII-CREB signaling. NeuroReport 28(13):856\u2013863. https:\/\/doi.org\/10.1097\/wnr.0000000000000849","journal-title":"NeuroReport"},{"issue":"6","key":"4485_CR104","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.bmcl.2003.09.103","volume":"14","author":"T Li","year":"2004","unstructured":"Li T, Saro D, Spaller MR (2004) Thermodynamic profiling of conformationally constrained cyclic ligands for the PDZ domain. Bioorg Med Chem Lett 14(6):1385\u20131388. https:\/\/doi.org\/10.1016\/j.bmcl.2003.09.103","journal-title":"Bioorg Med Chem Lett"},{"issue":"4","key":"4485_CR105","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.chembiol.2004.03.013","volume":"11","author":"A Piserchio","year":"2004","unstructured":"Piserchio A, Salinas GD, Li T, Marshall J, Spaller MR, Mierke DF (2004) Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem Biol 11(4):469\u2013473. https:\/\/doi.org\/10.1016\/j.chembiol.2004.03.013","journal-title":"Chem Biol"},{"issue":"2","key":"4485_CR106","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/s0306-4522(00)00193-7","volume":"98","author":"YX Tao","year":"2000","unstructured":"Tao YX, Huang YZ, Mei L, Johns RA (2000) Expression of PSD-95\/SAP90 is critical for N-methyl-D-aspartate receptor-mediated thermal hyperalgesia in the spinal cord. Neuroscience 98(2):201\u2013206. https:\/\/doi.org\/10.1016\/s0306-4522(00)00193-7","journal-title":"Neuroscience"},{"issue":"15","key":"4485_CR107","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1097\/00001756-200110290-00022","volume":"12","author":"F Tao","year":"2001","unstructured":"Tao F, Tao YX, Gonzalez JA, Fang M, Mao P, Johns RA (2001) Knockdown of PSD-95\/SAP90 delays the development of neuropathic pain in rats. NeuroReport 12(15):3251\u20133255. https:\/\/doi.org\/10.1097\/00001756-200110290-00022","journal-title":"NeuroReport"},{"issue":"4","key":"4485_CR108","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1007\/s13311-021-01158-8","volume":"18","author":"W Wei","year":"2021","unstructured":"Wei W, Liu W, Du S, Govindarajalu G, Irungu A, Bekker A, Tao YX (2021) A compound mitigates cancer pain and chemotherapy-induced neuropathic pain by dually targeting nNOS-PSD-95 interaction and GABA(A) receptor. Neurotherapeutics: J Am Soc Experimental NeuroTherapeutics 18(4):2436\u20132448. https:\/\/doi.org\/10.1007\/s13311-021-01158-8","journal-title":"Neurotherapeutics: J Am Soc Experimental NeuroTherapeutics"},{"key":"4485_CR109","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.neuropharm.2015.05.038","volume":"97","author":"WH Lee","year":"2015","unstructured":"Lee WH, Xu Z, Ashpole NM, Hudmon A, Kulkarni PM, Thakur GA, Lai YY, Hohmann AG (2015) Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics. Neuropharmacology 97:464\u2013475. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.05.038","journal-title":"Neuropharmacology"},{"key":"4485_CR110","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.neuroscience.2017.02.055","volume":"349","author":"LM Carey","year":"2017","unstructured":"Carey LM, Lee WH, Gutierrez T, Kulkarni PM, Thakur GA, Lai YY, Hohmann AG (2017) Small molecule inhibitors of PSD95-nNOS protein-protein interactions suppress formalin-evoked Fos protein expression and nociceptive behavior in rats. Neuroscience 349:303\u2013317. https:\/\/doi.org\/10.1016\/j.neuroscience.2017.02.055","journal-title":"Neuroscience"},{"issue":"2","key":"4485_CR111","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/j.1476-5381.2009.00300.x","volume":"158","author":"SK Florio","year":"2009","unstructured":"Florio SK, Loh C, Huang SM, Iwamaye AE, Kitto KF, Fowler KW, Treiberg JA, Hayflick JS et al (2009) Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents. Br J Pharmacol 158(2):494\u2013506. https:\/\/doi.org\/10.1111\/j.1476-5381.2009.00300.x","journal-title":"Br J Pharmacol"},{"key":"4485_CR112","doi-asserted-by":"publisher","first-page":"115698","DOI":"10.1016\/j.taap.2021.115698","volume":"429","author":"Z Sun","year":"2021","unstructured":"Sun Z, Meng P, Su C, Ji S, Gao Y, Wang H, Tian J, Li C (2021) PCC-0105002, a novel small molecule inhibitor of PSD95-nNOS protein-protein interactions, attenuates neuropathic pain and corrects motor disorder associated with neuropathic pain model. Toxicol Appl Pharmacol 429:115698. https:\/\/doi.org\/10.1016\/j.taap.2021.115698","journal-title":"Toxicol Appl Pharmacol"},{"issue":"9","key":"4485_CR113","doi-asserted-by":"publisher","first-page":"e74661","DOI":"10.1371\/journal.pone.0074661","volume":"8","author":"AS Wattiez","year":"2013","unstructured":"Wattiez AS, Pichon X, Dupuis A, Hern\u00e1ndez A, Privat AM, Aissouni Y, Chalus M, Pelissier T et al (2013) Disruption of 5-HT2A receptor-PDZ protein interactions alleviates mechanical hypersensitivity in carrageenan-induced inflammation in rats. PLoS ONE 8(9):e74661. https:\/\/doi.org\/10.1371\/journal.pone.0074661","journal-title":"PLoS ONE"},{"issue":"9","key":"4485_CR114","doi-asserted-by":"publisher","first-page":"2624","DOI":"10.1016\/j.bmcl.2013.02.100","volume":"23","author":"N Bouzidi","year":"2013","unstructured":"Bouzidi N, Deokar H, Vogrig A, Boucherle B, Ripoche I, Abrunhosa-Thomas I, Dorr L, Wattiez AS et al (2013) Identification of PDZ ligands by docking-based virtual screening for the development of novel analgesic agents. Bioorg Med Chem Lett 23(9):2624\u20132627. https:\/\/doi.org\/10.1016\/j.bmcl.2013.02.100","journal-title":"Bioorg Med Chem Lett"},{"issue":"9","key":"4485_CR115","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1016\/j.pain.2013.06.009","volume":"154","author":"Z Aira","year":"2013","unstructured":"Aira Z, Buesa I, Garc\u00eda Del Ca\u00f1o G, Bilbao J, Do\u00f1ate F, Zimmermann M, Azkue JJ (2013) Transient, 5-HT2B receptor-mediated facilitation in neuropathic pain: up-regulation of PKC\u03b3 and engagement of the NMDA receptor in dorsal horn neurons. Pain 154(9):1865\u20131877. https:\/\/doi.org\/10.1016\/j.pain.2013.06.009","journal-title":"Pain"},{"issue":"2","key":"4485_CR116","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s11064-023-04049-w","volume":"49","author":"HL Li","year":"2024","unstructured":"Li HL, Guo RJ, Ai ZR, Han S, Guan Y, Li JF, Wang Y (2024) Upregulation of spinal MDGA1 in rats after nerve injury alters interactions between neuroligin-2 and postsynaptic scaffolding proteins and increases GluR1 subunit surface delivery in the spinal cord dorsal horn. Neurochem Res 49(2):507\u2013518. https:\/\/doi.org\/10.1007\/s11064-023-04049-w","journal-title":"Neurochem Res"},{"issue":"12","key":"4485_CR117","doi-asserted-by":"publisher","first-page":"e3310","DOI":"10.1002\/brb3.3310","volume":"13","author":"P Yang","year":"2023","unstructured":"Yang P, Chen H, Wang T, Su H, Li J, He Y, Su S (2023) Electroacupuncture promotes synaptic plasticity in rats with chronic inflammatory pain-related depression by upregulating BDNF\/TrkB\/CREB signaling pathway. Brain and behavior 13(12):e3310. https:\/\/doi.org\/10.1002\/brb3.3310","journal-title":"Brain and behavior"},{"key":"4485_CR118","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.jpsychires.2016.09.008","volume":"83","author":"A Rafalo-Ulinska","year":"2016","unstructured":"Rafalo-Ulinska A, Piotrowska J, Kryczyk A, Opoka W, Sowa-Kucma M, Misztak P, Rajkowska G, Stockmeier CA et al (2016) Zinc transporters protein level in postmortem brain of depressed subjects and suicide victims. J Psychiatr Res 83:220\u2013229. https:\/\/doi.org\/10.1016\/j.jpsychires.2016.09.008","journal-title":"J Psychiatr Res"},{"issue":"4","key":"4485_CR119","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1177\/0269881119896304","volume":"34","author":"C Shang","year":"2020","unstructured":"Shang C, Yao RM, Guo Y, Ding ZC, Sun LJ, Ran YH, Xue R, Wang HS et al (2020) Translocator protein-mediated fast-onset antidepressant-like and memory-enhancing effects in chronically stressed mice. J Psychopharmacol (Oxford, England) 34(4):441\u2013451. https:\/\/doi.org\/10.1177\/0269881119896304","journal-title":"J Psychopharmacol (Oxford, England)"},{"issue":"7","key":"4485_CR120","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1016\/j.pnpbp.2011.05.010","volume":"35","author":"CS Jernigan","year":"2011","unstructured":"Jernigan CS, Goswami DB, Austin MC, Iyo AH, Chandran A, Stockmeier CA, Karolewicz B (2011) The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 35(7):1774\u20131779. https:\/\/doi.org\/10.1016\/j.pnpbp.2011.05.010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"4485_CR121","doi-asserted-by":"publisher","first-page":"109644","DOI":"10.1016\/j.pnpbp.2019.109644","volume":"94","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Xiang Z, Jia Y, He X, Wang L, Cui W (2019) The Notch signaling pathway inhibitor Dapt alleviates autism-like behavior, autophagy and dendritic spine density abnormalities in a valproic acid-induced animal model of autism. Prog Neuropsychopharmacol Biol Psychiatry 94:109644. https:\/\/doi.org\/10.1016\/j.pnpbp.2019.109644","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"2","key":"4485_CR122","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1007\/s12035-022-03079-9","volume":"60","author":"M Wu","year":"2023","unstructured":"Wu M, Liao W, Zhang R, Gao Y, Chen T, Hua L, Cai F (2023) PTP1B inhibitor claramine rescues diabetes-induced spatial learning and memory impairment in mice. Mol Neurobiol 60(2):524\u2013544. https:\/\/doi.org\/10.1007\/s12035-022-03079-9","journal-title":"Mol Neurobiol"},{"issue":"2","key":"4485_CR123","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1097\/j.pain.0000000000002066","volume":"162","author":"D Brown","year":"2021","unstructured":"Brown D, Rosenthal N, K\u00f6nning A, Wager J (2021) Intergenerational transmission of chronic pain-related disability: the explanatory effects of depressive symptoms. Pain 162(2):653\u2013662. https:\/\/doi.org\/10.1097\/j.pain.0000000000002066","journal-title":"Pain"},{"issue":"4","key":"4485_CR124","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1097\/ajp.0000000000000797","volume":"36","author":"JM G\u00f3mez Penedo","year":"2020","unstructured":"G\u00f3mez Penedo JM, Rubel JA, Bl\u00e4ttler L, Schmidt SJ, Stewart J, Egloff N, Grosse Holtforth M (2020) The complex interplay of pain, depression, and anxiety symptoms in patients with chronic pain: a network approach. Clin J Pain 36(4):249\u2013259. https:\/\/doi.org\/10.1097\/ajp.0000000000000797","journal-title":"Clin J Pain"},{"issue":"5","key":"4485_CR125","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1097\/j.pain.0000000000001487","volume":"160","author":"RV Aaron","year":"2019","unstructured":"Aaron RV, Fisher EA, de la Vega R, Lumley MA, Palermo TM (2019) Alexithymia in individuals with chronic pain and its relation to pain intensity, physical interference, depression, and anxiety: a systematic review and meta-analysis. Pain 160(5):994\u20131006. https:\/\/doi.org\/10.1097\/j.pain.0000000000001487","journal-title":"Pain"},{"issue":"8","key":"4485_CR126","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1001\/jamainternmed.2017.1622","volume":"177","author":"EL Whitlock","year":"2017","unstructured":"Whitlock EL, Diaz-Ramirez LG, Glymour MM, Boscardin WJ, Covinsky KE, Smith AK (2017) Association between persistent pain and memory decline and dementia in a longitudinal cohort of elders. JAMA Intern Med 177(8):1146\u20131153. https:\/\/doi.org\/10.1001\/jamainternmed.2017.1622","journal-title":"JAMA Intern Med"},{"issue":"3","key":"4485_CR127","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.7150\/thno.44364","volume":"11","author":"CL Mai","year":"2021","unstructured":"Mai CL, Tan Z, Xu YN, Zhang JJ, Huang ZH, Wang D, Zhang H, Gui WS et al (2021) CXCL12-mediated monocyte transmigration into brain perivascular space leads to neuroinflammation and memory deficit in neuropathic pain. Theranostics 11(3):1059\u20131078. https:\/\/doi.org\/10.7150\/thno.44364","journal-title":"Theranostics"},{"issue":"11","key":"4485_CR128","doi-asserted-by":"publisher","first-page":"4385","DOI":"10.1038\/s41380-022-01707-3","volume":"27","author":"SR Guerreiro","year":"2022","unstructured":"Guerreiro SR, Guimar\u00e3es MR, Silva JM, Dioli C, Vamvaka-Iakovou A, Sousa R, Gomes P, Megalokonomou A et al (2022) Chronic pain causes tau-mediated hippocampal pathology and memory deficits. Mol Psychiatry 27(11):4385\u20134393. https:\/\/doi.org\/10.1038\/s41380-022-01707-3","journal-title":"Mol Psychiatry"},{"issue":"6","key":"4485_CR129","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.apmr.2021.01.072","volume":"102","author":"C Joyce","year":"2021","unstructured":"Joyce C, Roseen EJ, Keysor JJ, Gross KD, Culpepper L, Saper RB (2021) Can yoga or physical therapy for chronic low back pain improve depression and anxiety among adults from a racially diverse, low-income community? A secondary analysis of a randomized controlled trial. Arch Phys Med Rehabil 102(6):1049\u20131058. https:\/\/doi.org\/10.1016\/j.apmr.2021.01.072","journal-title":"Arch Phys Med Rehabil"},{"issue":"2","key":"4485_CR130","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1177\/1359105311434605","volume":"18","author":"T Orenius","year":"2013","unstructured":"Orenius T, Koskela T, Koho P, Pohjolainen T, Kautiainen H, Haanp\u00e4\u00e4 M, Hurri H (2013) Anxiety and depression are independent predictors of quality of life of patients with chronic musculoskeletal pain. J Health Psychol 18(2):167\u2013175. https:\/\/doi.org\/10.1177\/1359105311434605","journal-title":"J Health Psychol"},{"issue":"5","key":"4485_CR131","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.cell.2016.07.008","volume":"166","author":"M Zeng","year":"2016","unstructured":"Zeng M, Shang Y, Araki Y, Guo T, Huganir RL, Zhang M (2016) Phase transition in postsynaptic densities underlies formation of synaptic complexes and synaptic plasticity. Cell 166(5):1163-1175.e1112. https:\/\/doi.org\/10.1016\/j.cell.2016.07.008","journal-title":"Cell"},{"issue":"2","key":"4485_CR132","doi-asserted-by":"publisher","first-page":"111483","DOI":"10.1016\/j.celrep.2022.111483","volume":"41","author":"AS Ravi","year":"2022","unstructured":"Ravi AS, Zeng M, Chen X, Sandoval G, Diaz-Alonso J, Zhang M, Nicoll RA (2022) Long-term potentiation reconstituted with an artificial TARP\/PSD-95 complex. Cell Rep 41(2):111483. https:\/\/doi.org\/10.1016\/j.celrep.2022.111483","journal-title":"Cell Rep"},{"key":"4485_CR133","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fnmol.2020.00010","volume":"13","author":"JY Delgado","year":"2020","unstructured":"Delgado JY, Nall D, Selvin PR (2020) Pin1 binding to phosphorylated PSD-95 regulates the number of functional excitatory synapses. Front Mol Neurosci 13:10. https:\/\/doi.org\/10.3389\/fnmol.2020.00010","journal-title":"Front Mol Neurosci"},{"issue":"10","key":"4485_CR134","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1038\/nn.2636","volume":"13","author":"J Jo","year":"2010","unstructured":"Jo J, Son GH, Winters BL, Kim MJ, Whitcomb DJ, Dickinson BA, Lee YB, Futai K et al (2010) Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95. Nat Neurosci 13(10):1216\u20131224. https:\/\/doi.org\/10.1038\/nn.2636","journal-title":"Nat Neurosci"},{"issue":"3","key":"4485_CR135","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3969\/j.issn.1673-5374.2013.03.003","volume":"8","author":"Q Xu","year":"2013","unstructured":"Xu Q, Liu T, Chen S, Gao Y, Wang J, Qiao L, Liu J (2013) Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica. Neural Regen Res 8(3):218\u2013225. https:\/\/doi.org\/10.3969\/j.issn.1673-5374.2013.03.003","journal-title":"Neural Regen Res"},{"issue":"1","key":"4485_CR136","doi-asserted-by":"publisher","first-page":"2501","DOI":"10.1038\/s41467-020-16198-5","volume":"11","author":"HY Liang","year":"2020","unstructured":"Liang HY, Chen ZJ, Xiao H, Lin YH, Hu YY, Chang L, Wu HY, Wang P et al (2020) nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors. Nat Commun 11(1):2501. https:\/\/doi.org\/10.1038\/s41467-020-16198-5","journal-title":"Nat Commun"},{"issue":"41","key":"4485_CR137","doi-asserted-by":"publisher","first-page":"7837","DOI":"10.1523\/jneurosci.2487-19.2020","volume":"40","author":"SH Liang","year":"2020","unstructured":"Liang SH, Zhao WJ, Yin JB, Chen YB, Li JN, Feng B, Lu YC, Wang J et al (2020) A neural circuit from thalamic paraventricular nucleus to central amygdala for the facilitation of neuropathic pain. J Neurosci: Off J Soc Neurosci 40(41):7837\u20137854. https:\/\/doi.org\/10.1523\/jneurosci.2487-19.2020","journal-title":"J Neurosci: Off J Soc Neurosci"},{"key":"4485_CR138","doi-asserted-by":"publisher","first-page":"106776","DOI":"10.1016\/j.phrs.2023.106776","volume":"191","author":"G Zhang","year":"2023","unstructured":"Zhang G, Cui M, Ji R, Zou S, Song L, Fan B, Yang L, Wang D et al (2023) Neural and molecular investigation into the paraventricular thalamic-nucleus accumbens circuit for pain sensation and non-opioid analgesia. Pharmacol Res 191:106776. https:\/\/doi.org\/10.1016\/j.phrs.2023.106776","journal-title":"Pharmacol Res"},{"issue":"2","key":"4485_CR139","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/s41386-023-01748-4","volume":"49","author":"QQ Tang","year":"2024","unstructured":"Tang QQ, Wu Y, Tao Q, Shen Y, An X, Liu D, Xu Z (2024) Direct paraventricular thalamus-basolateral amygdala circuit modulates neuropathic pain and emotional anxiety. Neuropsychopharmacol: Off Public Am College Neuropsychopharmacol 49(2):455\u2013466. https:\/\/doi.org\/10.1038\/s41386-023-01748-4","journal-title":"Neuropsychopharmacol: Off Public Am College Neuropsychopharmacol"},{"key":"4485_CR140","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainresbull.2022.07.008","volume":"188","author":"WT Zhang","year":"2022","unstructured":"Zhang WT, Sha WL, Zhu Q, Wu XB, He C (2022) Plasticity of neuronal excitability and synaptic balance in the anterior nucleus of paraventricular thalamus after nerve injury. Brain Res Bull 188:1\u201310. https:\/\/doi.org\/10.1016\/j.brainresbull.2022.07.008","journal-title":"Brain Res Bull"},{"issue":"11","key":"4485_CR141","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1016\/j.neuron.2023.03.014","volume":"111","author":"Y Liu","year":"2023","unstructured":"Liu Y, Li A, Bair-Marshall C, Xu H, Jee HJ, Zhu E, Sun M, Zhang Q et al (2023) Oxytocin promotes prefrontal population activity via the PVN-PFC pathway to regulate pain. Neuron 111(11):1795-1811.e1797. https:\/\/doi.org\/10.1016\/j.neuron.2023.03.014","journal-title":"Neuron"},{"issue":"3","key":"4485_CR142","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1097\/j.pain.0000000000002750","volume":"164","author":"YC Li","year":"2023","unstructured":"Li YC, Wang Q, Li MG, Hu SF, Xu GY (2023) A paraventricular hypothalamic nucleus input to ventral of lateral septal nucleus controls chronic visceral pain. Pain 164(3):625\u2013637. https:\/\/doi.org\/10.1097\/j.pain.0000000000002750","journal-title":"Pain"},{"issue":"5","key":"4485_CR143","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1097\/j.pain.0000000000001497","volume":"160","author":"YT Chang","year":"2019","unstructured":"Chang YT, Chen WH, Shih HC, Min MY, Shyu BC, Chen CC (2019) Anterior nucleus of paraventricular thalamus mediates chronic mechanical hyperalgesia. Pain 160(5):1208\u20131223. https:\/\/doi.org\/10.1097\/j.pain.0000000000001497","journal-title":"Pain"},{"issue":"24","key":"4485_CR144","doi-asserted-by":"publisher","first-page":"E3131","DOI":"10.1073\/pnas.1506488112","volume":"112","author":"X Huang","year":"2015","unstructured":"Huang X, Stodieck SK, Goetze B, Cui L, Wong MH, Wenzel C, Hosang L, Dong Y et al (2015) Progressive maturation of silent synapses governs the duration of a critical period. Proc Natl Acad Sci USA 112(24):E3131-3140. https:\/\/doi.org\/10.1073\/pnas.1506488112","journal-title":"Proc Natl Acad Sci USA"},{"issue":"50","key":"4485_CR145","doi-asserted-by":"publisher","first-page":"E6983","DOI":"10.1073\/pnas.1517045112","volume":"112","author":"X Chen","year":"2015","unstructured":"Chen X, Levy JM, Hou A, Winters C, Azzam R, Sousa AA, Leapman RD, Nicoll RA et al (2015) PSD-95 family MAGUKs are essential for anchoring AMPA and NMDA receptor complexes at the postsynaptic density. Proc Natl Acad Sci USA 112(50):E6983-6992. https:\/\/doi.org\/10.1073\/pnas.1517045112","journal-title":"Proc Natl Acad Sci USA"},{"key":"4485_CR146","doi-asserted-by":"publisher","first-page":"118281","DOI":"10.1016\/j.neuroimage.2021.118281","volume":"239","author":"SR Gefferie","year":"2021","unstructured":"Gefferie SR, Maric A, Critelli H, Gueden S, Kurlemann G, Kurth S, Nosadini M, Plecko B et al (2021) Altered EEG markers of synaptic plasticity in a human model of NMDA receptor deficiency: Anti-NMDA receptor encephalitis. Neuroimage 239:118281. https:\/\/doi.org\/10.1016\/j.neuroimage.2021.118281","journal-title":"Neuroimage"},{"issue":"12","key":"4485_CR147","doi-asserted-by":"publisher","first-page":"3687","DOI":"10.1007\/s00213-019-05341-w","volume":"236","author":"JS Burgdorf","year":"2019","unstructured":"Burgdorf JS, Christian EP, S\u00f8rensen L, Stanton PK, Leaderbrand K, Madsen TM, Khan MA, Kroes RA et al (2019) A translational EEG-based approach to assess modulation of long-lasting NMDAR-dependent synaptic plasticity. Psychopharmacology 236(12):3687\u20133693. https:\/\/doi.org\/10.1007\/s00213-019-05341-w","journal-title":"Psychopharmacology"},{"issue":"9","key":"4485_CR148","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1109\/tnsre.2019.2932104","volume":"27","author":"M Jochumsen","year":"2019","unstructured":"Jochumsen M, Navid MS, Rashid U, Haavik H, Niazi IK (2019) EMG- versus EEG-triggered electrical stimulation for inducing corticospinal plasticity. IEEE Transact Neural Syst Rehab Eng: Public IEEE Eng Med Biol Soc 27(9):1901\u20131908. https:\/\/doi.org\/10.1109\/tnsre.2019.2932104","journal-title":"IEEE Transact Neural Syst Rehab Eng: Public IEEE Eng Med Biol Soc"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04485-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04485-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04485-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T06:06:37Z","timestamp":1738562797000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04485-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":148,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["4485"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04485-x","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,16]]},"assertion":[{"value":"4 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}