{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:12:41Z","timestamp":1789704761687,"version":"4.0.1"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.827013\/2023-00"],"award-info":[{"award-number":["88887.827013\/2023-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.822397\/2023-00"],"award-info":[{"award-number":["88887.822397\/2023-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["304413\/2015\u20131"],"award-info":[{"award-number":["304413\/2015\u20131"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2023\/13575-3"],"award-info":[{"award-number":["2023\/13575-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s12035-024-04526-5","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T13:02:59Z","timestamp":1727442179000},"page":"6968-6982","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Molecular Alterations in Core Subunits of Mitochondrial Complex I and Their Relation to Parkinson\u2019s Disease"],"prefix":"10.1007","volume":"62","author":[{"given":"Matheus Caetano","family":"Epifane-de-Assun\u00e7\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Gabrielle","family":"Bispo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ndrea","family":"Ribeiro-dos-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna C.","family":"Cavalcante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"issue":"5","key":"4526_CR1","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/s41583-024-00806-0","volume":"25","author":"M Kampmann","year":"2024","unstructured":"Kampmann M (2024) Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases. Nat Rev Neurosci 25(5):351\u2013371","journal-title":"Nat Rev Neurosci"},{"key":"4526_CR2","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.conb.2005.05.007","volume":"15","author":"D James Surmeier","year":"2005","unstructured":"James Surmeier D, Mercer JN, Savio Chan C (2005) Autonomous pacemakers in the basal ganglia: who needs excitatory synapses anyway? Curr Opin Neurobiol 15:312\u2013318","journal-title":"Curr Opin Neurobiol"},{"key":"4526_CR3","doi-asserted-by":"publisher","unstructured":"Zampese E, Wokosin DL, Gonz\u00e1lez-Rodr\u00edguez P, Guzm\u00e1n J, Tkatch T, Kondapalli J et al (2022) Ca 2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons. Sci Adv 8(39). https:\/\/doi.org\/10.1126\/sciadv.abp8701","DOI":"10.1126\/sciadv.abp8701"},{"key":"4526_CR4","doi-asserted-by":"crossref","unstructured":"Gigu\u00e8re N, Delignat-Lavaud B, Herborg F, Voisin A, Li Y, Jacquemet V et al (2019) Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout. Petrou S, editor. PLOS Genet 15:e1008352","DOI":"10.1371\/journal.pgen.1008352"},{"key":"4526_CR5","doi-asserted-by":"publisher","unstructured":"Pissadaki EK, Bolam JP (2013) The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson\u2019s disease. Front Comput Neurosci 7. https:\/\/doi.org\/10.3389\/fncom.2013.00013","DOI":"10.3389\/fncom.2013.00013"},{"key":"4526_CR6","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/S0006-8993(99)01573-5","volume":"834","author":"J Gauthier","year":"1999","unstructured":"Gauthier J, Parent M, L\u00e9vesque M, Parent A (1999) The axonal arborization of single nigrostriatal neurons in rats. Brain Res 834:228\u2013232","journal-title":"Brain Res"},{"key":"4526_CR7","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1111\/jnc.12686","volume":"129","author":"J Segura-Aguilar","year":"2014","unstructured":"Segura-Aguilar J, Paris I, Mu\u00f1oz P, Ferrari E, Zecca L, Zucca FA (2014) Protective and toxic roles of dopamine in Parkinson\u2019s disease. J Neurochem 129:898\u2013915","journal-title":"J Neurochem"},{"key":"4526_CR8","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/jnc.13731","volume":"139","author":"A Bose","year":"2016","unstructured":"Bose A, Beal MF (2016) Mitochondrial dysfunction in Parkinson\u2019s disease. J Neurochem 139:216\u2013231","journal-title":"J Neurochem"},{"key":"4526_CR9","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s10541-005-0105-4","volume":"70","author":"M Bras","year":"2005","unstructured":"Bras M, Queenan B, Susin SA (2005) Programmed cell death via mitochondria: different modes of dying. Biochem Mosc 70:231\u2013239","journal-title":"Biochem Mosc"},{"key":"4526_CR10","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/nchem.1924","volume":"6","author":"YY Tyurina","year":"2014","unstructured":"Tyurina YY, Poloyac SM, Tyurin VA, Kapralov AA, Jiang J, Anthonymuthu TS et al (2014) A mitochondrial pathway for biosynthesis of lipid mediators. Nat Chem 6:542\u2013552","journal-title":"Nat Chem"},{"key":"4526_CR11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1042\/bio_2022_119","volume":"44","author":"RP Chakrabarty","year":"2022","unstructured":"Chakrabarty RP, Chandel NS (2022) Beyond ATP, new roles of mitochondria. Biochemist 44:2\u20138","journal-title":"Biochemist"},{"key":"4526_CR12","doi-asserted-by":"publisher","first-page":"200224","DOI":"10.1098\/rsob.200224","volume":"10","author":"AM Morelli","year":"2020","unstructured":"Morelli AM, Ravera S, Panfoli I (2020) The aerobic mitochondrial ATP synthesis from a comprehensive point of view. Open Biol 10:200224","journal-title":"Open Biol"},{"key":"4526_CR13","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1146\/annurev.bi.54.070185.005055","volume":"54","author":"Y Hatefi","year":"1985","unstructured":"Hatefi Y (1985) The mitochondrial electron transport and oxidative phosphorylation system. Annu Rev Biochem 54:1015\u20131069","journal-title":"Annu Rev Biochem"},{"key":"4526_CR14","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.mito.2019.10.008","volume":"50","author":"MH Barros","year":"2020","unstructured":"Barros MH, McStay GP (2020) Modular biogenesis of mitochondrial respiratory complexes. Mitochondrion 50:94\u2013114","journal-title":"Mitochondrion"},{"key":"4526_CR15","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1089\/ars.2009.2704","volume":"12","author":"G Lenaz","year":"2010","unstructured":"Lenaz G, Genova ML (2010) Structure and organization of mitochondrial respiratory complexes: a new understanding of an old subject. Antioxid Redox Signal 12:961\u20131008","journal-title":"Antioxid Redox Signal"},{"key":"4526_CR16","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1146\/annurev-biochem-070511-103700","volume":"82","author":"J Hirst","year":"2013","unstructured":"Hirst J (2013) Mitochondrial Complex I. Annu Rev Biochem 82:551\u2013575","journal-title":"Annu Rev Biochem"},{"key":"4526_CR17","doi-asserted-by":"crossref","unstructured":"Zorova LD, Popkov VA, Plotnikov EY, Silachev DN, Pevzner IB, Jankauskas SS et al (2018) Mitochondrial membrane potential. Anal Biochem [Internet] 552:50\u201359.\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5792320\/. Accessed 25 Apr 2024","DOI":"10.1016\/j.ab.2017.07.009"},{"key":"4526_CR18","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s10545-006-0362-4","volume":"29","author":"RJRJ Janssen","year":"2006","unstructured":"Janssen RJRJ, Nijtmans LG, van den Heuvel LP, Smeitink JAM (2006) Mitochondrial complex I: structure, function and pathology. J Inherit Metab Dis 29:499\u2013515","journal-title":"J Inherit Metab Dis"},{"key":"4526_CR19","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s10863-014-9554-z","volume":"46","author":"LA Sazanov","year":"2014","unstructured":"Sazanov LA (2014) The mechanism of coupling between electron transfer and proton translocation in respiratory complex I. J Bioenerg Biomembr 46:247\u2013253","journal-title":"J Bioenerg Biomembr"},{"key":"4526_CR20","doi-asserted-by":"publisher","first-page":"147434","DOI":"10.1016\/j.brainres.2021.147434","volume":"1767","author":"N Subrahmanian","year":"2021","unstructured":"Subrahmanian N, LaVoie MJ (2021) Is there a special relationship between complex I activity and nigral neuronal loss in Parkinson\u2019s disease? A critical reappraisal. Brain Res 1767:147434","journal-title":"Brain Res"},{"key":"4526_CR21","first-page":"1","volume":"11","author":"M Borsche","year":"2020","unstructured":"Borsche M, Pereira SL, Klein C, Gr\u00fcnewald A (2020) Mitochondria and Parkinson\u2019s disease: clinical, molecular, and translational aspects. J Parkinson\u2019s Dis 11:1\u201316","journal-title":"J Parkinson\u2019s Dis"},{"key":"4526_CR22","doi-asserted-by":"publisher","unstructured":"Henrich MT, Oertel WH, Surmeier DJ, Geibl FF (2023) Mitochondrial dysfunction in Parkinson\u2019s disease \u2013 a key disease hallmark with therapeutic potential. Mol Neurodegeneration 18. https:\/\/doi.org\/10.1186\/s13024-023-00676-7","DOI":"10.1186\/s13024-023-00676-7"},{"key":"4526_CR23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s00204-017-2133-4","volume":"92","author":"A Terron","year":"2017","unstructured":"Terron A, Bal-Price A, Paini A, Monnet-Tschudi F, Bennekou SH, Leist M et al (2017) An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition. Arch Toxicol 92:41\u201382","journal-title":"Arch Toxicol"},{"key":"4526_CR24","doi-asserted-by":"publisher","first-page":"504","DOI":"10.3390\/jcm9020504","volume":"9","author":"A Picca","year":"2020","unstructured":"Picca A, Guerra F, Calvani R, Marini F, Biancolillo A, Landi G et al (2020) Mitochondrial signatures in circulating extracellular vesicles of older adults with Parkinson\u2019s disease: results from the EXosomes in PArkiNson\u2019s Disease (EXPAND) study. J Clin Med 9:504","journal-title":"J Clin Med"},{"key":"4526_CR25","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/j.bcp.2004.02.015","volume":"67","author":"D Ben-Shachar","year":"2004","unstructured":"Ben-Shachar D, Zuk R, Gazawi H, Ljubuncic P (2004) Dopamine toxicity involves mitochondrial complex I inhibition: implications to dopamine-related neuropsychiatric disorders. Biochem Pharmacol 67:1965\u20131974","journal-title":"Biochem Pharmacol"},{"key":"4526_CR26","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1083\/jcb.201009132","volume":"192","author":"W-S Choi","year":"2011","unstructured":"Choi W-S, Palmiter RD, Xia Z (2011) Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson\u2019s disease model. J Cell Biol 192:873\u2013882","journal-title":"J Cell Biol"},{"key":"4526_CR27","doi-asserted-by":"publisher","first-page":"51783","DOI":"10.1074\/jbc.M407336200","volume":"279","author":"G-R Kweon","year":"2004","unstructured":"Kweon G-R, Marks JD, Krencik R, Leung EH, Schumacker PT, Hyland K et al (2004) Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells. J Biol Chem 279:51783\u201351792","journal-title":"J Biol Chem"},{"key":"4526_CR28","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1038\/81834","volume":"3","author":"R Betarbet","year":"2000","unstructured":"Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT (2000) Chronic systemic pesticide exposure reproduces features of Parkinson\u2019s disease. Nat Neurosci 3:1301\u20131306","journal-title":"Nat Neurosci"},{"key":"4526_CR29","doi-asserted-by":"crossref","unstructured":"Gr\u00fcnewald A, Kumar KR, Sue CM (2019) New insights into the complex role of mitochondria in Parkinson\u2019s disease. Prog Neurobiol [Internet] 177:73\u201393.\u00a0https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0301008218300650","DOI":"10.1016\/j.pneurobio.2018.09.003"},{"key":"4526_CR30","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1111\/j.1471-4159.1990.tb02325.x","volume":"54","author":"AHV Schapira","year":"1990","unstructured":"Schapira AHV, Cooper JM, Dexter D, Clark JB, Jenner P, Marsden CD (1990) Mitochondrial complex I deficiency in Parkinson\u2019s disease. J Neurochem 54:823\u2013827","journal-title":"J Neurochem"},{"key":"4526_CR31","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.brainres.2007.10.061","volume":"1189","author":"WD Parker","year":"2008","unstructured":"Parker WD, Parks JK, Swerdlow RH (2008) Complex I deficiency in Parkinson\u2019s disease frontal cortex. Brain Res 1189:215\u2013218","journal-title":"Brain Res"},{"key":"4526_CR32","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Rodr\u00edguez P, Zampese E, Stout KA, Guzman JN, Ilijic E, Yang B et al (2021) Disruption of mitochondrial complex I induces progressive parkinsonism. Nature [Internet]. 1\u20137.\u00a0https:\/\/www.nature.com\/articles\/s41586-021-04059-0","DOI":"10.1038\/s41586-021-04059-0"},{"key":"4526_CR33","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.tig.2015.01.004","volume":"31","author":"A Verstraeten","year":"2015","unstructured":"Verstraeten A, Theuns J, Van Broeckhoven C (2015) Progress in unraveling the genetic etiology of Parkinson disease in a genomic era. Trends Genet 31:140\u2013149","journal-title":"Trends Genet"},{"key":"4526_CR34","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1038\/ng.3955","volume":"49","author":"D Chang","year":"2017","unstructured":"Chang D, Nalls MA, Hallgr\u00edmsd\u00f3ttir IB, Hunkapiller J, van der Brug M, Cai F et al (2017) A meta-analysis of genome-wide association studies identifies 17 new Parkinson\u2019s disease risk loci. Nat Genet 49:1511\u20131516","journal-title":"Nat Genet"},{"key":"4526_CR35","doi-asserted-by":"crossref","unstructured":"Engin HB, Kreisberg JF, Carter H (2016) Structure-based analysis reveals cancer missense mutations target protein interaction interfaces. PLoS ONE [Internet]. 11:e0152929.\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4820104\/","DOI":"10.1371\/journal.pone.0152929"},{"key":"4526_CR36","doi-asserted-by":"publisher","unstructured":"Habib I, Khan S, Mohammad T, Hussain A, Alajmi MF, Rehman T et al (2021) Impact of non-synonymous mutations on the structure and function of telomeric repeat binding factor 1. J Biomol Struct Dyn 1\u201314. https:\/\/doi.org\/10.1080\/07391102.2021.1922313","DOI":"10.1080\/07391102.2021.1922313"},{"key":"4526_CR37","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.sbi.2015.01.003","volume":"32","author":"TG Kucukkal","year":"2015","unstructured":"Kucukkal TG, Petukh M, Li L, Alexov E (2015) Structural and physico-chemical effects of disease and non-disease nsSNPs on proteins. Curr Opin Struct Biol 32:18\u201324","journal-title":"Curr Opin Struct Biol"},{"key":"4526_CR38","doi-asserted-by":"publisher","unstructured":"Havranek B, Islam SM (2020) Prediction and evaluation of deleterious and disease causing non-synonymous SNPs (nsSNPs) in human NF2 gene responsible for neurofibromatosis type 2 (NF2). J Biomol Struct Dyn 1\u201312. https:\/\/doi.org\/10.1080\/07391102.2020.1805018","DOI":"10.1080\/07391102.2020.1805018"},{"key":"4526_CR39","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1016\/j.bbabio.2010.05.009","volume":"1797","author":"MA Tocilescu","year":"2010","unstructured":"Tocilescu MA, Zickermann V, Zwicker K, Brandt U (2010) Quinone binding and reduction by respiratory complex I. Biochim Biophys Acta 1797:1883\u20131890","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"4526_CR40","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41580-021-00415-0","volume":"23","author":"I Vercellino","year":"2021","unstructured":"Vercellino I, Sazanov LA (2021) The assembly, regulation and function of the mitochondrial respiratory chain. Nat Rev Mol Cell Biol 23(2):141","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4526_CR41","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.semcdb.2017.08.011","volume":"76","author":"LE Formosa","year":"2018","unstructured":"Formosa LE, Dibley MG, Stroud DA, Ryan MT (2018) Building a complex complex: assembly of mitochondrial respiratory chain complex I. Semin Cell Dev Biol 76:154\u2013162","journal-title":"Semin Cell Dev Biol"},{"key":"4526_CR42","doi-asserted-by":"publisher","first-page":"6350","DOI":"10.1093\/hmg\/ddv344","volume":"24","author":"F Varghese","year":"2015","unstructured":"Varghese F, Atcheson E, Bridges HR, Hirst J (2015) Characterization of clinically identified mutations in NDUFV1, the flavin-binding subunit of respiratory complex I, using a yeast model system. Hum Mol Genet 24:6350\u20136360","journal-title":"Hum Mol Genet"},{"key":"4526_CR43","doi-asserted-by":"crossref","unstructured":"Srivastava A, Srivastava KR, Hebbar M, Galada C, Kadavigrere R, Su F et al (2018) Genetic diversity of NDUFV1-dependent mitochondrial complex I deficiency. Eur J Hum Genet [Internet] 26:1582\u20131587.\u00a0[cited 2024 Jan 8].\u00a0https:\/\/www.nature.com\/articles\/s41431-018-0209-0. Accessed 24 Apr 2024","DOI":"10.1038\/s41431-018-0209-0"},{"issue":"12","key":"4526_CR44","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/s41570-020-00223-8","volume":"4","author":"AC Conibear","year":"2020","unstructured":"Conibear AC (2020) Deciphering protein post-translational modifications using chemical biology tools. Nat Rev Chem 4(12):674\u2013695","journal-title":"Nat Rev Chem"},{"key":"4526_CR45","doi-asserted-by":"publisher","first-page":"102302","DOI":"10.1016\/j.isci.2021.102302","volume":"24","author":"B Li","year":"2021","unstructured":"Li B, Yang Y, Wang Y, Zhang J, Ding J, Liu X et al (2021) Acetylation of NDUFV1 induced by a newly synthesized HDAC6 inhibitor HGC rescues dopaminergic neuron loss in Parkinson models. iScience. 24:102302","journal-title":"iScience."},{"issue":"8","key":"4526_CR46","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1007\/s11064-023-03907-x","volume":"48","author":"Y Chithra","year":"2023","unstructured":"Chithra Y, Dey G, Ghose V, Chandramohan V, Gowthami N, Vasudev V et al (2023) Mitochondrial complex I inhibition in dopaminergic neurons causes altered protein profile and protein oxidation: implications for Parkinson\u2019s disease. Neurochem Res 48(8):2360\u20132389","journal-title":"Neurochem Res"},{"key":"4526_CR47","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.brainres.2015.08.028","volume":"1625","author":"T Chen","year":"2015","unstructured":"Chen T, Wu Q, Zhang Y, Zhang D (2015) NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar\u2013bipolar transition. Brain Res 1625:102\u2013110","journal-title":"Brain Res"},{"key":"4526_CR48","doi-asserted-by":"crossref","unstructured":"Bergman O, Karry R, Milhem J, Ben-Shachar D (2018) NDUFV2 pseudogene (NDUFV2P1) contributes to mitochondrial complex I deficits in schizophrenia. Mol Psychiatry [Internet]. [cited 2019 Sep 22].\u00a0https:\/\/www.nature.com\/articles\/s41380-018-0309-9. Accessed 11 Mar 2024","DOI":"10.1038\/s41380-018-0309-9"},{"key":"4526_CR49","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.jad.2015.05.060","volume":"184","author":"S Akarsu","year":"2015","unstructured":"Akarsu S, Torun D, Erdem M, Kozan S, Akar H, Uzun \u00d6 (2015) Mitochondrial complex I and III mRNA levels in bipolar disorder. J Affect Disord 184:160\u2013163","journal-title":"J Affect Disord"},{"key":"4526_CR50","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1136\/jmedgenet-2020-107383","volume":"59","author":"Z Liu","year":"2021","unstructured":"Liu Z, Zhang L, Ren C, Xu M, Li S, Ban R et al (2021) Whole genome and exome sequencing identify NDUFV2 mutations as a new cause of progressive cavitating leukoencephalopathy. J Med Genet 59:351\u2013357","journal-title":"J Med Genet"},{"key":"4526_CR51","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1006\/geno.1997.5192","volume":"49","author":"N Hattori","year":"1998","unstructured":"Hattori N, Yoshino H, Tanaka M, Suzuki H, Mizuno Y (1998) Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease. Genomics 49:52\u201358","journal-title":"Genomics"},{"key":"4526_CR52","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.parkreldis.2010.09.007","volume":"16","author":"K Nishioka","year":"2010","unstructured":"Nishioka K, Vilari\u00f1o-G\u00fcell C, Cobb SA, Kachergus JM, Ross OA, Hentati E et al (2010) Genetic variation of the mitochondrial complex I subunit NDUFV2 and Parkinson\u2019s disease. Parkinsonism Relat Disord 16:686\u2013687","journal-title":"Parkinsonism Relat Disord"},{"key":"4526_CR53","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.jns.2006.05.053","volume":"247","author":"RH Swerdlow","year":"2006","unstructured":"Swerdlow RH, Weaver B, Grawey A, Wenger C, Freed E, Worrall BB (2006) Complex I polymorphisms, bigenomic heterogeneity, and family history in Virginians with Parkinson\u2019s disease. J Neurol Sci 247:224\u2013230","journal-title":"J Neurol Sci"},{"key":"4526_CR54","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jchemneu.2018.02.004","volume":"95","author":"N Gowthami","year":"2019","unstructured":"Gowthami N, Sunitha B, Kumar M, Prasad K, Gayathri N, Padmanabhan B et al (2019) Mapping the protein phosphorylation sites in human mitochondrial complex I (NADH: Ubiquinone oxidoreductase): a bioinformatics study with implications for brain aging and neurodegeneration. J Chem Neuroanat 95:13\u201328","journal-title":"J Chem Neuroanat"},{"issue":"5","key":"4526_CR55","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1007\/s00125-020-05103-w","volume":"63","author":"B Qi","year":"2020","unstructured":"Qi B, He L, Zhao Y, Zhang L, He Y, Li J et al (2020) Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis. Diabetologia 63(5):1072\u20131087","journal-title":"Diabetologia"},{"key":"4526_CR56","first-page":"1","volume":"2021","author":"R Zou","year":"2021","unstructured":"Zou R, Tao J, Qiu J, Shi W, Zou M, Chen W et al (2021) Ndufs1 deficiency aggravates the mitochondrial membrane potential dysfunction in pressure overload-induced myocardial hypertrophy. Oxidative Med Cell Longev (Online) 2021:1\u201321","journal-title":"Oxidative Med Cell Longev (Online)"},{"key":"4526_CR57","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3390\/cells8101149","volume":"8","author":"Y Ni","year":"2019","unstructured":"Ni Y, Hagras MA, Konstantopoulou V, Mayr JA, Stuchebrukhov AA, Meierhofer D (2019) Mutations in NDUFS1 cause metabolic reprogramming and disruption of the electron transfer. Cells 8:1149","journal-title":"Cells"},{"key":"4526_CR58","doi-asserted-by":"publisher","first-page":"586","DOI":"10.3390\/ijms22020586","volume":"22","author":"M Protasoni","year":"2021","unstructured":"Protasoni M, Zeviani M (2021) Mitochondrial structure and bioenergetics in normal and disease conditions. Int J Mol Sci 22:586","journal-title":"Int J Mol Sci"},{"key":"4526_CR59","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.mito.2021.03.003","volume":"58","author":"AB Bandara","year":"2021","unstructured":"Bandara AB, Drake JC, James CC, Smyth JW, Brown DA (2021) Complex I protein NDUFS2 is vital for growth, ROS generation, membrane integrity, apoptosis, and mitochondrial energetics. Mitochondrion 58:160\u2013168","journal-title":"Mitochondrion"},{"key":"4526_CR60","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1093\/brain\/awq232","volume":"133","author":"HAL Tuppen","year":"2010","unstructured":"Tuppen HAL, Hogan VE, He L, Blakely EL, Worgan L, Al-Dosary M et al (2010) The p. M292T NDUFS2 mutation causes complex I-deficient Leigh syndrome in multiple families. Brain 133:2952\u201363","journal-title":"Brain"},{"key":"4526_CR61","doi-asserted-by":"crossref","unstructured":"Verkaart S, Koopman WJH, van Emst-de Vries SE, Nijtmans LGJ, van den Heuvel LWPJ, Smeitink JAM et al (2007) Superoxide production is inversely related to complex I activity in inherited complex I deficiency. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1772:373\u201381","DOI":"10.1016\/j.bbadis.2006.12.009"},{"key":"4526_CR62","unstructured":"Chanthammachat P, Dharmasaroja P (2019) Metformin restores the mitochondrial membrane potentials in association with a reduction in TIMM23 and NDUFS3 in MPP+-induced neurotoxicity in SH-SY5Y cells. PubMed [Internet] 18:812\u2013823. [cited 2024 Feb 15].\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6806136\/. Accessed 29 Mar 2024"},{"key":"4526_CR63","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1242\/bio.20133244","volume":"2","author":"S Suhane","year":"2013","unstructured":"Suhane S, Kanzaki H, Arumugaswami V, Murali R, Ramanujan VK (2013) Mitochondrial NDUFS3 regulates the ROS-mediated onset of metabolic switch in transformed cells. Biology Open 2:295\u2013305","journal-title":"Biology Open"},{"key":"4526_CR64","doi-asserted-by":"publisher","first-page":"299","DOI":"10.4103\/jpn.JPN_182_20","volume":"16","author":"D Samanta","year":"2021","unstructured":"Samanta D, Veerapandiyan A, Burrow TA, Gokden M (2021) Mitochondrial ultrastructural defects in NDUFS3-related disorder. J Pediatr Neurosci 16:299\u2013309","journal-title":"J Pediatr Neurosci"},{"key":"4526_CR65","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/s10038-018-0505-0","volume":"63","author":"X Lou","year":"2018","unstructured":"Lou X, Shi H, Wen S, Li Y, Wei X, Xie J et al (2018) A novel NDUFS3 mutation in a Chinese patient with severe Leigh syndrome. J Hum Genet 63:1269\u20131272","journal-title":"J Hum Genet"},{"key":"4526_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/8940850","volume":"2016","author":"AK Machado","year":"2016","unstructured":"Machado AK, Andreazza AC, da Silva TM, Boligon AA, do Nascimento V, Scola G et al (2016) Neuroprotective effects of A\u00e7a\u00ed (Euterpe oleracea Mart.) against rotenone in vitro exposure. Oxidative Med Cell Longev 2016:1\u201314","journal-title":"Oxidative Med Cell Longev"},{"key":"4526_CR67","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.ymgme.2007.05.010","volume":"92","author":"S Lebon","year":"2007","unstructured":"Lebon S, Minai L, Chretien D, Corcos J, Serre V, Kadhom N et al (2007) A novel mutation of the NDUFS7 gene leads to activation of a cryptic exon and impaired assembly of mitochondrial complex I in a patient with Leigh syndrome. Mol Genet Metab 92:104\u2013108","journal-title":"Mol Genet Metab"},{"key":"4526_CR68","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.biocel.2015.05.017","volume":"65","author":"G Leman","year":"2015","unstructured":"Leman G, Gueguen N, Desquiret-Dumas V, Selma Kane M, Wettervald C, Chupin S et al (2015) Assembly defects induce oxidative stress in inherited mitochondrial complex I deficiency. Int J Biochem Cell Biol 65:91\u2013103","journal-title":"Int J Biochem Cell Biol"},{"key":"4526_CR69","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.bbabio.2019.06.006","volume":"1860","author":"EG Yoga","year":"2019","unstructured":"Yoga EG, Haapanen O, Wittig I, Siegmund K, Sharma V, Zickermann V (2019) Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics. Biochim Biophys Acta 1860:573\u2013581","journal-title":"Biochim Biophys Acta"},{"key":"4526_CR70","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1002\/glia.23290","volume":"66","author":"M-J Cabirol-Pol","year":"2017","unstructured":"Cabirol-Pol M-J, Khalil B, Rival T, Faivre-Sarrailh C, Besson MT (2017) Glial lipid droplets and neurodegeneration in a Drosophila model of complex I deficiency. Glia 66:874\u2013888","journal-title":"Glia"},{"key":"4526_CR71","doi-asserted-by":"crossref","unstructured":"Haack TB, Haberberger B, Frisch E-M, Wieland T, Iuso A, Gorza M et al (2012) Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing. J Med Genet [Internet] 49:277\u2013283.\u00a0[cited 2022 Mar 7].\u00a0https:\/\/epub.ub.uni-muenchen.de\/21895\/1\/oa_21895.pdf. Accessed 16 Apr 2024","DOI":"10.1136\/jmedgenet-2012-100846"},{"key":"4526_CR72","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1007\/s00109-005-0712-y","volume":"83","author":"R Hinttala","year":"2005","unstructured":"Hinttala R, Uusimaa J, Remes AM, Rantala H, Hassinen IE, Majamaa K (2005) Sequence analysis of nuclear genes encoding functionally important complex I subunits in children with encephalomyopathy. J Mol Med 83:786\u2013794","journal-title":"J Mol Med"},{"key":"4526_CR73","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.tcb.2018.06.006","volume":"28","author":"K Fiedorczuk","year":"2018","unstructured":"Fiedorczuk K, Sazanov LA (2018) Mammalian mitochondrial complex I structure and disease-causing mutations. Trends Cell Biol 28:835\u2013867","journal-title":"Trends Cell Biol"},{"key":"4526_CR74","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s11596-023-2771-0","volume":"43","author":"Y Xu","year":"2023","unstructured":"Xu Y, Su J, Zhou J, Yuan Q, Han J (2023) Roles of MT-ND1 in cancer. Curr Med Sci 43:869\u2013878","journal-title":"Curr Med Sci"},{"key":"4526_CR75","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0531-5565(02)00266-8","volume":"38","author":"OA Ross","year":"2003","unstructured":"Ross OA, McCormack R, Maxwell LD, Duguid RA, Quinn DJ, Barnett Y et al (2003) mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson\u2019s disease in the Irish. Exp Gerontol 38:397\u2013405","journal-title":"Exp Gerontol"},{"issue":"5","key":"4526_CR76","doi-asserted-by":"publisher","first-page":"4373","DOI":"10.1007\/s11033-021-06452-4","volume":"48","author":"E Mkaouar-Rebai","year":"2021","unstructured":"Mkaouar-Rebai E, Ammar M, Sfaihi L, Alila-Fersi O, Maalej M, Felhi R et al (2021) Mitochondrial disease patients with novel ND4 12058A > C and ND1 m.3911A > G variations: implications for a role in the phenotype following a bioinformatic investigation. Mol Biol Rep 48(5):4373\u20134382","journal-title":"Mol Biol Rep"},{"key":"4526_CR77","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ymgme.2006.08.003","volume":"90","author":"C Ugalde","year":"2007","unstructured":"Ugalde C, Hinttala R, Timal S, Smeets R, Rodenburg RJ, Uusimaa J et al (2007) Mutated ND2 impairs mitochondrial complex I assembly and leads to Leigh Syndrome. Mol Genet Metab 90:10\u201314","journal-title":"Mol Genet Metab"},{"key":"4526_CR78","doi-asserted-by":"crossref","unstructured":"Gusdon AM, Fang F, Chen J, Mathews CE, Li W, Chu CT et al (2015) Association of the mt-ND2 5178A\/C polymorphism with Parkinson\u2019s disease. Neurosci Lett [Internet] 587:98\u2013101.\u00a0[cited 2024 Mar 13].\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4934122\/. Accessed 17 Apr 2024","DOI":"10.1016\/j.neulet.2014.12.005"},{"key":"4526_CR79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/4728714","volume":"2021","author":"L Tian","year":"2021","unstructured":"Tian L, Zhu C, Yang H, Li Y, Liu Y (2021) Protective effect of mitochondrial nd2 c5178a gene mutation on cell and mitochondrial functions. Oxid Med Cell Longev 2021:1\u201310","journal-title":"Oxid Med Cell Longev"},{"key":"4526_CR80","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/sj.ejhg.5201425","volume":"13","author":"D Ghezzi","year":"2005","unstructured":"Ghezzi D, Marelli C, Achilli A, Goldwurm S, Pezzoli G, Barone P et al (2005) Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson\u2019s disease in Italians. Eur J Hum Genet 13:748\u2013752","journal-title":"Eur J Hum Genet"},{"key":"4526_CR81","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1086\/373937","volume":"72","author":"JM Van der Walt","year":"2003","unstructured":"Van der Walt JM, Nicodemus KK, Martin ER, Scott WK, Nance MA, Watts RL et al (2003) Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease. Am J Human Genet 72:804\u2013811","journal-title":"Am J Human Genet"},{"key":"4526_CR82","doi-asserted-by":"publisher","unstructured":"Chu Q, Luo X, Zhan X, Ren Y, Pang H (2015) Female genetic distribution bias in mitochondrial genome observed in Parkinson\u2019s disease patients in northern China. Sci Rep 5. https:\/\/doi.org\/10.1038\/srep17170","DOI":"10.1038\/srep17170"},{"key":"4526_CR83","doi-asserted-by":"publisher","first-page":"e104879","DOI":"10.1371\/journal.pone.0104879","volume":"9","author":"DK Miller","year":"2014","unstructured":"Miller DK, Menezes MJ, Simons C, Riley LG, Cooper ST, Grimmond SM et al (2014) Rapid identification of a novel complex I MT-ND3 m10134C>A mutation in a Leigh syndrome patient. PloS One 9:e104879-9","journal-title":"PloS One"},{"key":"4526_CR84","doi-asserted-by":"publisher","first-page":"e566","DOI":"10.1212\/NXG.0000000000000566","volume":"7","author":"H Bruhn","year":"2021","unstructured":"Bruhn H, Samuelsson K, Schober FA, Engvall M, Lesko N, Wibom R et al (2021) Novel mutation m.10372A>G in MT-ND3 causing sensorimotor axonal polyneuropathy. Neurol Genet 7:e566","journal-title":"Neurol Genet"},{"key":"4526_CR85","doi-asserted-by":"publisher","first-page":"42763","DOI":"10.1074\/jbc.M112.422824","volume":"287","author":"J Torres-Bacete","year":"2012","unstructured":"Torres-Bacete J, Sinha PK, Sato M, Patki G, Kao M-C, Matsuno-Yagi A et al (2012) Roles of subunit NuoK (ND4L) in the energy-transducing mechanism of Escherichia coli NDH-1 (NADH: Quinone Oxidoreductase). J Biol Chem 287:42763\u201372","journal-title":"J Biol Chem"},{"key":"4526_CR86","doi-asserted-by":"publisher","first-page":"117793222097867","DOI":"10.1177\/1177932220978672","volume":"14","author":"W Destiarani","year":"2020","unstructured":"Destiarani W, Mulyani R, Yusuf M, Maksum IP (2020) Molecular dynamics simulation of T10609C and C10676G mutations of Mitochondrial ND4L gene associated with proton translocation in type 2 diabetes mellitus and cataract patients. Bioinform Biol Insights 14:117793222097867","journal-title":"Bioinform Biol Insights"},{"key":"4526_CR87","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1136\/bjophthalmol-2013-304140","volume":"98","author":"R Behbehani","year":"2014","unstructured":"Behbehani R, Melhem M, Alghanim G, Behbehani K, Alsmadi O (2014) ND4L gene concurrent 10609T>C and 10663T>C mutations are associated with Leber\u2019s hereditary optic neuropathy in a large pedigree from Kuwait. Br J Ophthalmol 98:826\u2013831","journal-title":"Br J Ophthalmol"},{"key":"4526_CR88","doi-asserted-by":"publisher","unstructured":"Alharbi M, Al-Kafaji G, Khalaf N, Messaoudi S, Taha S, Daif A et al (2019) Four novel mutations in the mitochondrial ND4 gene of complex I in patients with multiple sclerosis. Biomed Rep.\u00a0https:\/\/doi.org\/10.3892\/br.2019.1250","DOI":"10.3892\/br.2019.1250"},{"key":"4526_CR89","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.ajhg.2008.08.013","volume":"83","author":"S Ellouze","year":"2008","unstructured":"Ellouze S, Augustin S, Bouaita A, Bonnet C, Simonutti M, Forster V et al (2008) Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction. Am J Human Genet 83:373\u2013387","journal-title":"Am J Human Genet"},{"key":"4526_CR90","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/1202459","volume":"2017","author":"W Yan","year":"2017","unstructured":"Yan W, Kang Y, Ji X, Li S, Li Y, Zhang G et al (2017) Testosterone upregulates the expression of mitochondrial ND1 and ND4 and alleviates the oxidative damage to the nigrostriatal dopaminergic system in orchiectomized rats. Oxid Med Cell Longev 2017:1\u201313","journal-title":"Oxid Med Cell Longev"},{"key":"4526_CR91","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1093\/brain\/123.9.1896","volume":"123","author":"R Lodi","year":"2000","unstructured":"Lodi R (2000) `Secondary\u2019 4216\/ND1 and 13708\/ND5 Leber\u2019s hereditary optic neuropathy mitochondrial DNA mutations do not further impair in vivo mitochondrial oxidative metabolism when associated with the 11778\/ND4 mitochondrial DNA mutation. Brain 123:1896\u20131902","journal-title":"Brain"},{"key":"4526_CR92","doi-asserted-by":"publisher","unstructured":"Pignataro D, Francia S, Zanetta F, Brenna G, Brandini S, Olivieri A et al (2017) A missense MT-ND5 mutation in differentiated Parkinson disease cytoplasmic hybrid induces ROS-dependent DNA Damage Response amplified by DROSHA. Sci Rep 7. https:\/\/doi.org\/10.1038\/s41598-017-09910-x","DOI":"10.1038\/s41598-017-09910-x"},{"key":"4526_CR93","doi-asserted-by":"publisher","unstructured":"Danhelovska T, Kolarova H, Zeman J, Hansikova H, Vaneckova M, Lambert L et al (2020) Multisystem mitochondrial diseases due to mutations in mtDNA-encoded subunits of complex I. BMC Pediatr 20. https:\/\/doi.org\/10.1186\/s12887-020-1912-x","DOI":"10.1186\/s12887-020-1912-x"},{"key":"4526_CR94","doi-asserted-by":"publisher","unstructured":"Fang H, Shi H, Li X, Sun D, Li F, Li B et al (2015) Exercise intolerance and developmental delay associated with a novel mitochondrial ND5 mutation. Sci Rep 5. https:\/\/doi.org\/10.1038\/srep10480","DOI":"10.1038\/srep10480"},{"key":"4526_CR95","doi-asserted-by":"publisher","first-page":"e0154371","DOI":"10.1371\/journal.pone.0154371","volume":"11","author":"M McKenzie","year":"2016","unstructured":"McKenzie M, Duchen MR (2016) Impaired cellular bioenergetics causes mitochondrial calcium handling defects in MT-ND5 mutant cybrids. PLoS ONE 11:e0154371-e154381","journal-title":"PLoS ONE"},{"key":"4526_CR96","doi-asserted-by":"publisher","unstructured":"Chen D, Zhao Q, Xiong J, Lou X, Han Q, Wei X et al (2020) Systematic analysis of a mitochondrial disease\u2010causing ND6 mutation in mitochondrial deficiency. Molec Genet Gen Med 8. https:\/\/doi.org\/10.1002\/mgg3.1199","DOI":"10.1002\/mgg3.1199"},{"key":"4526_CR97","doi-asserted-by":"crossref","unstructured":"Kishita Y, Ishikawa K, Nakada K, Hayashi J-I, Fushimi T, Shimura M et al (2021) A high mutation load of m.14597A>G in MT-ND6 causes Leigh syndrome. Sci Rep [Internet] 11:11123.\u00a0[cited 2021 Oct 7].\u00a0https:\/\/www.nature.com\/articles\/s41598-021-90196-5. Accessed 4 July 2024","DOI":"10.1038\/s41598-021-90196-5"},{"key":"4526_CR98","doi-asserted-by":"crossref","unstructured":"Ghosh N, Das A, Chaffee S, Roy S, Sen CK (2018) Reactive oxygen species, oxidative damage and cell death. Immunity and Inflammation in Health and Disease [Internet]. pp 45\u201355.\u00a0https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780128054178000044. Accessed 28 Apr 2024","DOI":"10.1016\/B978-0-12-805417-8.00004-4"},{"key":"4526_CR99","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","volume":"97","author":"B Wang","year":"2023","unstructured":"Wang B, Wang Y, Zhang J, Hu C, Jiang J, Li Y et al (2023) ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis. Arch Toxicol 97:1439\u20131451","journal-title":"Arch Toxicol"},{"key":"4526_CR100","doi-asserted-by":"crossref","unstructured":"Wilson DM, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I (2023) Hallmarks of neurodegenerative diseases. Cell [Internet] 186:693\u2013714.https:\/\/www.cell.com\/cell\/pdf\/S0092-8674(22)01575-6.pdf. Accessed 28 Apr 2024","DOI":"10.1016\/j.cell.2022.12.032"},{"key":"4526_CR101","doi-asserted-by":"crossref","unstructured":"Surmeier DJ, Obeso JA, Halliday GM (2017) Selective neuronal vulnerability in Parkinson disease. Nat Rev Neurosci [Internet] 18:101\u2013113.\u00a0https:\/\/www.nature.com\/articles\/nrn.2016.178. Accessed 28 Apr 2024","DOI":"10.1038\/nrn.2016.178"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04526-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04526-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04526-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:03:21Z","timestamp":1747195401000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04526-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,27]]},"references-count":101,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["4526"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04526-5","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,27]]},"assertion":[{"value":"31 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}