{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:53:40Z","timestamp":1791233620075,"version":"4.1.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC: 81971115"],"award-info":[{"award-number":["NSFC: 81971115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC: 32300982"],"award-info":[{"award-number":["NSFC: 32300982"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["SGLH20180629094602262"],"award-info":[{"award-number":["SGLH20180629094602262"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s12035-024-04536-3","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T02:02:27Z","timestamp":1729648947000},"page":"4319-4337","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Connexin43 Contributes to Alzheimer\u2019s Disease by Promoting the Mitochondria-Associated Membrane-Related Autophagy Inhibition"],"prefix":"10.1007","volume":"62","author":[{"given":"Weiwei","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8914-5753","authenticated-orcid":false,"given":"Yining","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"4536_CR1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/b978-0-12-386986-9.00011-9","volume":"102","author":"SD Skaper","year":"2012","unstructured":"Skaper SD (2012) Alzheimer\u2019s disease and amyloid: culprit or coincidence? Int Rev Neurobiol 102:277\u2013316. https:\/\/doi.org\/10.1016\/b978-0-12-386986-9.00011-9","journal-title":"Int Rev Neurobiol"},{"issue":"6","key":"4536_CR2","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.jalz.2015.05.016","volume":"11","author":"M Baumgart","year":"2015","unstructured":"Baumgart M, Snyder HM, Carrillo MC, Fazio S, Kim H, Johns H (2015) Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective. Alzheimers Dement 11(6):718\u2013726. https:\/\/doi.org\/10.1016\/j.jalz.2015.05.016","journal-title":"Alzheimers Dement"},{"issue":"1","key":"4536_CR3","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/ene.13439","volume":"25","author":"CA Lane","year":"2018","unstructured":"Lane CA, Hardy J, Schott JM (2018) Alzheimer\u2019s disease. Eur J Neurol 25(1):59\u201370. https:\/\/doi.org\/10.1111\/ene.13439","journal-title":"Eur J Neurol"},{"key":"4536_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.npep.2015.06.008","volume":"52","author":"SH Barage","year":"2015","unstructured":"Barage SH, Sonawane KD (2015) Amyloid cascade hypothesis: pathogenesis and therapeutic strategies in Alzheimer\u2019s disease. Neuropeptides 52:1\u201318. https:\/\/doi.org\/10.1016\/j.npep.2015.06.008","journal-title":"Neuropeptides"},{"issue":"5054","key":"4536_CR5","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1126\/science.1566067","volume":"256","author":"JA Hardy","year":"1992","unstructured":"Hardy JA, Higgins GA (1992) Alzheimer\u2019s disease: the amyloid cascade hypothesis. Science 256(5054):184\u2013185. https:\/\/doi.org\/10.1126\/science.1566067","journal-title":"Science"},{"key":"4536_CR6","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.12688\/f1000research.14506.1","volume":"7","author":"J Weller","year":"2018","unstructured":"Weller J, Budson A (2018) Current understanding of Alzheimer\u2019s disease diagnosis and treatment. F1000Res 7:1161. https:\/\/doi.org\/10.12688\/f1000research.14506.1","journal-title":"F1000Res"},{"issue":"1","key":"4536_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/alzrt59","volume":"3","author":"RJ Bateman","year":"2011","unstructured":"Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA et al (2011) Autosomal-dominant Alzheimer\u2019s disease: a review and proposal for the prevention of Alzheimer\u2019s disease. Alzheimers Res Ther 3(1):1. https:\/\/doi.org\/10.1186\/alzrt59","journal-title":"Alzheimers Res Ther"},{"issue":"9","key":"4536_CR8","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.tins.2008.06.005","volume":"31","author":"I Bezprozvanny","year":"2008","unstructured":"Bezprozvanny I, Mattson MP (2008) Neuronal calcium mishandling and the pathogenesis of Alzheimer\u2019s disease. Trends Neurosci 31(9):454\u2013463. https:\/\/doi.org\/10.1016\/j.tins.2008.06.005","journal-title":"Trends Neurosci"},{"issue":"7","key":"4536_CR9","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1023\/a:1011603916962","volume":"26","author":"JW Pettegrew","year":"2001","unstructured":"Pettegrew JW, Panchalingam K, Hamilton RL, McClure RJ (2001) Brain membrane phospholipid alterations in Alzheimer\u2019s disease. Neurochem Res 26(7):771\u2013782. https:\/\/doi.org\/10.1023\/a:1011603916962","journal-title":"Neurochem Res"},{"issue":"1","key":"4536_CR10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2174\/156720509787313899","volume":"6","author":"M Stefani","year":"2009","unstructured":"Stefani M, Liguri G (2009) Cholesterol in Alzheimer\u2019s disease: unresolved questions. Curr Alzheimer Res 6(1):15\u201329. https:\/\/doi.org\/10.2174\/156720509787313899","journal-title":"Curr Alzheimer Res"},{"issue":"Suppl 1","key":"4536_CR11","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1471-4159.2009.05867.x","volume":"109","author":"X Wang","year":"2009","unstructured":"Wang X, Su B, Zheng L, Perry G, Smith MA, Zhu X (2009) The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer\u2019s disease. J Neurochem 109(Suppl 1):153\u2013159. https:\/\/doi.org\/10.1111\/j.1471-4159.2009.05867.x","journal-title":"J Neurochem"},{"issue":"6054","key":"4536_CR12","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1126\/science.1207385","volume":"334","author":"JR Friedman","year":"2011","unstructured":"Friedman JR, Lackner LL, West M, DiBenedetto JR, Nunnari J, Voeltz GK (2011) ER tubules mark sites of mitochondrial division. Science 334(6054):358\u2013362. https:\/\/doi.org\/10.1126\/science.1207385","journal-title":"Science"},{"issue":"3","key":"4536_CR13","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/s41419-017-0105-5","volume":"9","author":"J Janikiewicz","year":"2018","unstructured":"Janikiewicz J, Szyma\u0144ski J, Malinska D, Patalas-Krawczyk P, Michalska B, Duszy\u0144ski J, Giorgi C, Bonora M et al (2018) Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics. Cell Death Dis 9(3):332. https:\/\/doi.org\/10.1038\/s41419-017-0105-5","journal-title":"Cell Death Dis"},{"issue":"7222","key":"4536_CR14","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nature07534","volume":"456","author":"OM de Brito","year":"2008","unstructured":"de Brito OM, Scorrano L (2008) Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 456(7222):605\u2013610. https:\/\/doi.org\/10.1038\/nature07534","journal-title":"Nature"},{"key":"4536_CR15","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.brainresbull.2021.05.020","volume":"173","author":"W Shi","year":"2021","unstructured":"Shi W, Wu H, Liu S, Wu Z, Wu H, Liu J, Hou Y (2021) Progesterone suppresses cholesterol esterification in APP\/PS1 mice and a cell model of Alzheimer\u2019s disease. Brain Res Bull 173:162\u2013173. https:\/\/doi.org\/10.1016\/j.brainresbull.2021.05.020","journal-title":"Brain Res Bull"},{"issue":"7","key":"4536_CR16","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.3390\/ijms18071576","volume":"18","author":"J Szyma\u0144ski","year":"2017","unstructured":"Szyma\u0144ski J, Janikiewicz J, Michalska B, Patalas-Krawczyk P, Perrone M, Zi\u00f3\u0142kowski W, Duszy\u0144ski J, Pinton P et al (2017) Interaction of mitochondria with the endoplasmic reticulum and plasma membrane in calcium homeostasis, lipid trafficking and mitochondrial structure. Int J Mol Sci 18(7):1576. https:\/\/doi.org\/10.3390\/ijms18071576","journal-title":"Int J Mol Sci"},{"issue":"21","key":"4536_CR17","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.1038\/emboj.2012.202","volume":"31","author":"E Area-Gomez","year":"2012","unstructured":"Area-Gomez E, Del Carmen Lara Castillo M, Tambini MD, Guardia-Laguarta C, de Groof AJ, Madra M, Ikenouchi J, Umeda M et al (2012) Upregulated function of mitochondria-associated ER membranes in Alzheimer disease. Embo J 31(21):4106\u20134123. https:\/\/doi.org\/10.1038\/emboj.2012.202","journal-title":"Embo J"},{"issue":"19","key":"4536_CR18","doi-asserted-by":"publisher","first-page":"7916","DOI":"10.1073\/pnas.1300677110","volume":"110","author":"L Hedskog","year":"2013","unstructured":"Hedskog L, Pinho CM, Filadi R, R\u00f6nnb\u00e4ck A, Hertwig L, Wiehager B, Larssen P, Gellhaar S et al (2013) Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer\u2019s disease and related models. Proc Natl Acad Sci USA 110(19):7916\u20137921. https:\/\/doi.org\/10.1073\/pnas.1300677110","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"4536_CR19","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s11914-017-0345-4","volume":"15","author":"MC Moorer","year":"2017","unstructured":"Moorer MC, Stains JP (2017) Connexin43 and the intercellular signaling network regulating skeletal remodeling. Curr Osteoporos Rep 15(1):24\u201331. https:\/\/doi.org\/10.1007\/s11914-017-0345-4","journal-title":"Curr Osteoporos Rep"},{"issue":"1","key":"4536_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-019-0759-5","volume":"115","author":"M Wang","year":"2019","unstructured":"Wang M, Smith K, Yu Q, Miller C, Singh K, Sen CK (2019) Mitochondrial connexin 43 in sex-dependent myocardial responses and estrogen-mediated cardiac protection following acute ischemia\/reperfusion injury. Basic Res Cardiol 115(1):1. https:\/\/doi.org\/10.1007\/s00395-019-0759-5","journal-title":"Basic Res Cardiol"},{"issue":"44","key":"4536_CR21","doi-asserted-by":"publisher","first-page":"15097","DOI":"10.1074\/jbc.RA120.013705","volume":"295","author":"M Maulik","year":"2020","unstructured":"Maulik M, Vasan L, Bose A, Dutta Chowdhury S, Sengupta N, Das Sarma J (2020) Amyloid-\u03b2 regulates gap junction protein connexin 43 trafficking in cultured primary astrocytes. J Biol Chem 295(44):15097\u201315111. https:\/\/doi.org\/10.1074\/jbc.RA120.013705","journal-title":"J Biol Chem"},{"issue":"10","key":"4536_CR22","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1111\/1440-1681.13541","volume":"48","author":"J He","year":"2021","unstructured":"He J, Gong M, Wang Z, Liu D, Xie B, Luo C, Li G, Tse G et al (2021) Cardiac abnormalities after induction of endoplasmic reticulum stress are associated with mitochondrial dysfunction and connexin43 expression. Clin Exp Pharmacol Physiol 48(10):1371\u20131381. https:\/\/doi.org\/10.1111\/1440-1681.13541","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"4536_CR23","doi-asserted-by":"publisher","first-page":"910452","DOI":"10.3389\/fphys.2022.910452","volume":"13","author":"Y Lv","year":"2022","unstructured":"Lv Y, Cheng L, Peng F (2022) Compositions and functions of mitochondria-associated endoplasmic reticulum membranes and their contribution to cardioprotection by exercise preconditioning. Front Physiol 13:910452. https:\/\/doi.org\/10.3389\/fphys.2022.910452","journal-title":"Front Physiol"},{"issue":"1","key":"4536_CR24","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.cardiores.2005.05.015","volume":"68","author":"YD Barac","year":"2005","unstructured":"Barac YD, Zeevi-Levin N, Yaniv G, Reiter I, Milman F, Shilkrut M, Coleman R, Abassi Z et al (2005) The 1,4,5-inositol trisphosphate pathway is a key component in Fas-mediated hypertrophy in neonatal rat ventricular myocytes. Cardiovasc Res 68(1):75\u201386. https:\/\/doi.org\/10.1016\/j.cardiores.2005.05.015","journal-title":"Cardiovasc Res"},{"issue":"4","key":"4536_CR25","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.bbrc.2015.03.027","volume":"459","author":"H Zou","year":"2015","unstructured":"Zou H, Zhuo L, Han T, Hu D, Yang X, Wang Y, Yuan Y, Gu J et al (2015) Autophagy and gap junctional intercellular communication inhibition are involved in cadmium-induced apoptosis in rat liver cells. Biochem Biophys Res Commun 459(4):713\u2013719. https:\/\/doi.org\/10.1016\/j.bbrc.2015.03.027","journal-title":"Biochem Biophys Res Commun"},{"key":"4536_CR26","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12964-014-0058-6","volume":"12","author":"M Kang","year":"2014","unstructured":"Kang M, Lin N, Li C, Meng Q, Zheng Y, Yan X, Deng J, Ou Y et al (2014) Cx43 phosphorylation on S279\/282 and intercellular communication are regulated by IP3\/IP3 receptor signaling. Cell Commun Signal 12:58. https:\/\/doi.org\/10.1186\/s12964-014-0058-6","journal-title":"Cell Commun Signal"},{"issue":"10","key":"4536_CR27","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1038\/cdd.2016.63","volume":"23","author":"C Yi","year":"2016","unstructured":"Yi C, Mei X, Ezan P, Mato S, Matias I, Giaume C, Koulakoff A (2016) Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer\u2019s disease. Cell Death Differ 23(10):1691\u20131701. https:\/\/doi.org\/10.1038\/cdd.2016.63","journal-title":"Cell Death Differ"},{"issue":"1\u20132","key":"4536_CR28","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0006-8993(95)01526-4","volume":"717","author":"JI Nagy","year":"1996","unstructured":"Nagy JI, Li W, Hertzberg EL, Marotta CA (1996) Elevated connexin43 immunoreactivity at sites of amyloid plaques in Alzheimer\u2019s disease. Brain Res 717(1\u20132):173\u2013178. https:\/\/doi.org\/10.1016\/0006-8993(95)01526-4","journal-title":"Brain Res"},{"issue":"5","key":"4536_CR29","doi-asserted-by":"publisher","first-page":"794","DOI":"10.4161\/auto.19390","volume":"8","author":"JT Fong","year":"2012","unstructured":"Fong JT, Kells RM, Gumpert AM, Marzillier JY, Davidson MW, Falk MM (2012) Internalized gap junctions are degraded by autophagy. Autophagy 8(5):794\u2013811. https:\/\/doi.org\/10.4161\/auto.19390","journal-title":"Autophagy"},{"issue":"4","key":"4536_CR30","doi-asserted-by":"publisher","first-page":"636","DOI":"10.2337\/db17-0316","volume":"67","author":"E Tubbs","year":"2018","unstructured":"Tubbs E, Chanon S, Robert M, Bendridi N, Bidaux G, Chauvin MA, Ji-Cao J, Durand C et al (2018) Disruption of mitochondria-associated endoplasmic reticulum membrane (MAM) integrity contributes to muscle insulin resistance in mice and humans. Diabetes 67(4):636\u2013650. https:\/\/doi.org\/10.2337\/db17-0316","journal-title":"Diabetes"},{"key":"4536_CR31","doi-asserted-by":"publisher","unstructured":"Lokossou AG, Toufaily C, Vargas A, Barbeau B (2016) siRNA transfection and EMSA analyses on freshly isolated human villous cytotrophoblasts. J Vis Exp (115). https:\/\/doi.org\/10.3791\/53995","DOI":"10.3791\/53995"},{"key":"4536_CR32","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.phrs.2018.01.003","volume":"128","author":"R Filadi","year":"2018","unstructured":"Filadi R, Greotti E, Pizzo P (2018) Highlighting the endoplasmic reticulum-mitochondria connection: focus on mitofusin 2. Pharmacol Res 128:42\u201351. https:\/\/doi.org\/10.1016\/j.phrs.2018.01.003","journal-title":"Pharmacol Res"},{"issue":"1","key":"4536_CR33","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1042\/cs20200844","volume":"135","author":"W Yu","year":"2021","unstructured":"Yu W, Jin H, Huang Y (2021) Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer\u2019s disease. Clin Sci (Lond) 135(1):109\u2013126. https:\/\/doi.org\/10.1042\/cs20200844","journal-title":"Clin Sci (Lond)"},{"issue":"3","key":"4536_CR34","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00401-010-0652-7","volume":"119","author":"LT Grinberg","year":"2010","unstructured":"Grinberg LT, Thal DR (2010) Vascular pathology in the aged human brain. Acta Neuropathol 119(3):277\u2013290. https:\/\/doi.org\/10.1007\/s00401-010-0652-7","journal-title":"Acta Neuropathol"},{"key":"4536_CR35","doi-asserted-by":"publisher","first-page":"20709","DOI":"10.1038\/srep20709","volume":"6","author":"D van Westen","year":"2016","unstructured":"van Westen D, Lindqvist D, Blennow K, Minthon L, N\u00e4gga K, Stomrud E, Zetterberg H, Hansson O et al (2016) Cerebral white matter lesions - associations with A\u03b2 isoforms and amyloid PET. Sci Rep 6:20709. https:\/\/doi.org\/10.1038\/srep20709","journal-title":"Sci Rep"},{"issue":"2","key":"4536_CR36","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1385\/mn:34:2:81","volume":"34","author":"Y Chen","year":"2006","unstructured":"Chen Y, Aulia S, Tang BL (2006) Myelin-associated glycoprotein-mediated signaling in central nervous system pathophysiology. Mol Neurobiol 34(2):81\u201391. https:\/\/doi.org\/10.1385\/mn:34:2:81","journal-title":"Mol Neurobiol"},{"issue":"5","key":"4536_CR37","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s13238-011-1047-9","volume":"2","author":"F Zhou","year":"2011","unstructured":"Zhou F, van Laar T, Huang H, Zhang L (2011) APP and APLP1 are degraded through autophagy in response to proteasome inhibition in neuronal cells. Protein Cell 2(5):377\u2013383. https:\/\/doi.org\/10.1007\/s13238-011-1047-9","journal-title":"Protein Cell"},{"issue":"5","key":"4536_CR38","doi-asserted-by":"publisher","first-page":"1006.e1011","DOI":"10.1016\/j.neurobiolaging.2011.09.039","volume":"33","author":"SM Son","year":"2012","unstructured":"Son SM, Jung ES, Shin HJ, Byun J, Mook-Jung I (2012) A\u03b2-induced formation of autophagosomes is mediated by RAGE-CaMKK\u03b2-AMPK signaling. Neurobiol Aging 33(5):1006.e1011-1023. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2011.09.039","journal-title":"Neurobiol Aging"},{"issue":"5","key":"4536_CR39","doi-asserted-by":"publisher","first-page":"448","DOI":"10.3390\/cells8050488","volume":"8","author":"PH Reddy","year":"2019","unstructured":"Reddy PH, Oliver DM (2019) Amyloid beta and phosphorylated Tau-induced defective autophagy and mitophagy in Alzheimer\u2019s disease. Cells 8(5):448. https:\/\/doi.org\/10.3390\/cells8050488","journal-title":"Cells"},{"issue":"6","key":"4536_CR40","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.phrs.2012.07.004","volume":"66","author":"M Komatsu","year":"2012","unstructured":"Komatsu M, Kageyama S, Ichimura Y (2012) p62\/SQSTM1\/A170: physiology and pathology. Pharmacol Res 66(6):457\u2013462. https:\/\/doi.org\/10.1016\/j.phrs.2012.07.004","journal-title":"Pharmacol Res"},{"key":"4536_CR41","doi-asserted-by":"publisher","unstructured":"Fischer TD, Wang C, Padman BS, Lazarou M, Youle RJ (2020) STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain. J Cell Biol 219 (12). https:\/\/doi.org\/10.1083\/jcb.202009128","DOI":"10.1083\/jcb.202009128"},{"issue":"10","key":"4536_CR42","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/s41419-022-05318-2","volume":"13","author":"M Tiberti","year":"2022","unstructured":"Tiberti M, Di Leo L, Vistesen MV, Kuhre RS, Cecconi F, De Zio D, Papaleo E (2022) The Cancermuts software package for the prioritization of missense cancer variants: a case study of AMBRA1 in melanoma. Cell Death Dis 13(10):872. https:\/\/doi.org\/10.1038\/s41419-022-05318-2","journal-title":"Cell Death Dis"},{"key":"4536_CR43","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ymeth.2014.11.021","volume":"75","author":"P Jiang","year":"2015","unstructured":"Jiang P, Mizushima N (2015) LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells. Methods 75:13\u201318. https:\/\/doi.org\/10.1016\/j.ymeth.2014.11.021","journal-title":"Methods"},{"issue":"6b","key":"4536_CR44","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1111\/j.1582-4934.2008.00509.x","volume":"12","author":"JJ Pei","year":"2008","unstructured":"Pei JJ, Hugon J (2008) mTOR-dependent signalling in Alzheimer\u2019s disease. J Cell Mol Med 12(6b):2525\u20132532. https:\/\/doi.org\/10.1111\/j.1582-4934.2008.00509.x","journal-title":"J Cell Mol Med"},{"issue":"11","key":"4536_CR45","doi-asserted-by":"publisher","first-page":"8924","DOI":"10.1074\/jbc.M110.180638","volume":"286","author":"A Caccamo","year":"2011","unstructured":"Caccamo A, Maldonado MA, Majumder S, Medina DX, Holbein W, Magr\u00ed A, Oddo S (2011) Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism. J Biol Chem 286(11):8924\u20138932. https:\/\/doi.org\/10.1074\/jbc.M110.180638","journal-title":"J Biol Chem"},{"issue":"3","key":"4536_CR46","doi-asserted-by":"publisher","first-page":"823","DOI":"10.14670\/hh-19.823","volume":"19","author":"P Fern\u00e1ndez-Vizarra","year":"2004","unstructured":"Fern\u00e1ndez-Vizarra P, Fern\u00e1ndez AP, Castro-Blanco S, Serrano J, Bentura ML, Mart\u00ednez-Murillo R, Mart\u00ednez A, Rodrigo J (2004) Intra- and extracellular Abeta and PHF in clinically evaluated cases of Alzheimer\u2019s disease. Histol Histopathol 19(3):823\u2013844. https:\/\/doi.org\/10.14670\/hh-19.823","journal-title":"Histol Histopathol"},{"issue":"1","key":"4536_CR47","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/s0014-4886(03)00252-8","volume":"184","author":"V Blanchard","year":"2003","unstructured":"Blanchard V, Moussaoui S, Czech C, Touchet N, Bonici B, Planche M, Canton T, Jedidi I et al (2003) Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP\/PS1 transgenic mice. Exp Neurol 184(1):247\u2013263. https:\/\/doi.org\/10.1016\/s0014-4886(03)00252-8","journal-title":"Exp Neurol"},{"issue":"1","key":"4536_CR48","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.neuroscience.2010.08.001","volume":"171","author":"X Mei","year":"2010","unstructured":"Mei X, Ezan P, Giaume C, Koulakoff A (2010) Astroglial connexin immunoreactivity is specifically altered at \u03b2-amyloid plaques in \u03b2-amyloid precursor protein\/presenilin1 mice. Neuroscience 171(1):92\u2013105. https:\/\/doi.org\/10.1016\/j.neuroscience.2010.08.001","journal-title":"Neuroscience"},{"issue":"10","key":"4536_CR49","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1177\/0271678x211010354","volume":"41","author":"W Yu","year":"2021","unstructured":"Yu W, Jin H, Sun W, Nan D, Deng J, Jia J, Yu Z, Huang Y (2021) Connexin43 promotes angiogenesis through activating the HIF-1\u03b1\/VEGF signaling pathway under chronic cerebral hypoperfusion. J Cerebral Blood Flow Metabolism\u202f: Off J Int Society Cerebral Blood Flow Metabolism 41(10):2656\u20132675. https:\/\/doi.org\/10.1177\/0271678x211010354","journal-title":"J Cerebral Blood Flow Metabolism : Off J Int Society Cerebral Blood Flow Metabolism"},{"issue":"1","key":"4536_CR50","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s40478-018-0642-x","volume":"6","author":"Y Kajiwara","year":"2018","unstructured":"Kajiwara Y, Wang E, Wang M, Sin WC, Brennand KJ, Schadt E, Naus CC, Buxbaum J et al (2018) GJA1 (connexin43) is a key regulator of Alzheimer\u2019s disease pathogenesis. Acta Neuropathol Commun 6(1):144. https:\/\/doi.org\/10.1186\/s40478-018-0642-x","journal-title":"Acta Neuropathol Commun"},{"key":"4536_CR51","doi-asserted-by":"publisher","unstructured":"He JT, Li XY, Yang L, Zhao X (2020) Astroglial connexins and cognition: memory formation or deterioration? Biosci Rep 40 (1). https:\/\/doi.org\/10.1042\/bsr20193510","DOI":"10.1042\/bsr20193510"},{"issue":"5","key":"4536_CR52","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1002\/glia.22785","volume":"63","author":"V Abudara","year":"2015","unstructured":"Abudara V, Roux L, Dall\u00e9rac G, Matias I, Dulong J, Mothet JP, Rouach N, Giaume C (2015) Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes. Glia 63(5):795\u2013811. https:\/\/doi.org\/10.1002\/glia.22785","journal-title":"Glia"},{"key":"4536_CR53","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3389\/fphar.2013.00088","volume":"4","author":"C Giaume","year":"2013","unstructured":"Giaume C, Leybaert L, Naus CC, S\u00e1ez JC (2013) Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles. Front Pharmacol 4:88. https:\/\/doi.org\/10.3389\/fphar.2013.00088","journal-title":"Front Pharmacol"},{"issue":"1","key":"4536_CR54","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/glia.23080","volume":"65","author":"R Gajardo-Gomez","year":"2017","unstructured":"Gajardo-Gomez R, Labra VC, Maturana CJ, Shoji KF, Santibanez CA, Saez JC, Giaume C, Orellana JA (2017) Cannabinoids prevent the amyloid beta-induced activation of astroglial hemichannels: a neuroprotective mechanism. Glia 65(1):122\u2013137. https:\/\/doi.org\/10.1002\/glia.23080","journal-title":"Glia"},{"key":"4536_CR55","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bbamem.2017.05.008","volume":"1","author":"E Leithe","year":"1860","unstructured":"Leithe E, Mesnil M (1860) Aasen T (2018) The connexin 43 C-terminus: a tail of many tales. Biochim Biophys Acta Biomembr 1:48\u201364. https:\/\/doi.org\/10.1016\/j.bbamem.2017.05.008","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"4536_CR56","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/978-981-10-4567-7_11","volume":"997","author":"E Area-Gomez","year":"2017","unstructured":"Area-Gomez E, Schon EA (2017) Alzheimer disease. Adv Exp Med Biol 997:149\u2013156. https:\/\/doi.org\/10.1007\/978-981-10-4567-7_11","journal-title":"Adv Exp Med Biol"},{"key":"4536_CR57","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.lfs.2018.07.033","volume":"208","author":"R Ren","year":"2018","unstructured":"Ren R, Zhang L, Wang M (2018) Specific deletion connexin43 in astrocyte ameliorates cognitive dysfunction in APP\/PS1 mice. Life Sci 208:175\u2013191. https:\/\/doi.org\/10.1016\/j.lfs.2018.07.033","journal-title":"Life Sci"},{"issue":"13","key":"4536_CR58","doi-asserted-by":"publisher","first-page":"4962","DOI":"10.1523\/jneurosci.6417-10.2011","volume":"31","author":"JA Orellana","year":"2011","unstructured":"Orellana JA, Shoji KF, Abudara V, Ezan P, Amigou E, S\u00e1ez PJ, Jiang JX, Naus CC et al (2011) Amyloid \u03b2-induced death in neurons involves glial and neuronal hemichannels. J Neurosci\u202f: Off J Soc Neurosci 31(13):4962\u20134977. https:\/\/doi.org\/10.1523\/jneurosci.6417-10.2011","journal-title":"J Neurosci : Off J Soc Neurosci"},{"issue":"16","key":"4536_CR59","doi-asserted-by":"publisher","first-page":"10347","DOI":"10.1074\/jbc.M704153200","volume":"283","author":"MH Stridh","year":"2008","unstructured":"Stridh MH, Tranberg M, Weber SG, Blomstrand F, Sandberg M (2008) Stimulated efflux of amino acids and glutathione from cultured hippocampal slices by omission of extracellular calcium: likely involvement of connexin hemichannels. J Biol Chem 283(16):10347\u201310356. https:\/\/doi.org\/10.1074\/jbc.M704153200","journal-title":"J Biol Chem"},{"issue":"3","key":"4536_CR60","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1096\/fj.201601309","volume":"31","author":"E Area-Gomez","year":"2017","unstructured":"Area-Gomez E, Schon EA (2017) On the pathogenesis of Alzheimer\u2019s disease: the MAM hypothesis. Faseb j 31(3):864\u2013867. https:\/\/doi.org\/10.1096\/fj.201601309","journal-title":"Faseb j"},{"key":"4536_CR61","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.bbabio.2014.02.007","volume":"7","author":"CM Pinho","year":"1837","unstructured":"Pinho CM, Teixeira PF (1837) Glaser E (2014) Mitochondrial import and degradation of amyloid-\u03b2 peptide. Biochem Biophys Acta 7:1069\u20131074. https:\/\/doi.org\/10.1016\/j.bbabio.2014.02.007","journal-title":"Biochem Biophys Acta"},{"issue":"18","key":"4536_CR62","doi-asserted-by":"publisher","first-page":"5198","DOI":"10.1093\/hmg\/ddv241","volume":"24","author":"D Fang","year":"2015","unstructured":"Fang D, Wang Y, Zhang Z, Du H, Yan S, Sun Q, Zhong C, Wu L et al (2015) Increased neuronal PreP activity reduces A\u03b2 accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease\u2019s mouse model. Hum Mol Genet 24(18):5198\u20135210. https:\/\/doi.org\/10.1093\/hmg\/ddv241","journal-title":"Hum Mol Genet"},{"issue":"14","key":"4536_CR63","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1096\/fj.05-3735fje","volume":"19","author":"C Caspersen","year":"2005","unstructured":"Caspersen C, Wang N, Yao J, Sosunov A, Chen X, Lustbader JW, Xu HW, Stern D et al (2005) Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer\u2019s disease. Faseb j 19(14):2040\u20132041. https:\/\/doi.org\/10.1096\/fj.05-3735fje","journal-title":"Faseb j"},{"issue":"3","key":"4536_CR64","doi-asserted-by":"publisher","first-page":"19","DOI":"10.32607\/actanaturae.11723","volume":"14","author":"NS Nikolaeva","year":"2022","unstructured":"Nikolaeva NS, Yandulova EY, Aleksandrova YR, Starikov AS, Neganova ME (2022) The role of a pathological interaction between \u03b2-amyloid and mitochondria in the occurrence and development of Alzheimer\u2019s disease. Acta Naturae 14(3):19\u201334. https:\/\/doi.org\/10.32607\/actanaturae.11723","journal-title":"Acta Naturae"},{"key":"4536_CR65","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/978-4-431-56550-5_13","volume":"1006","author":"IV Majoul","year":"2017","unstructured":"Majoul IV, Ernesti JS, Butkevich EV, Duden R (2017) Drebrins and connexins: a biomedical perspective. Adv Exp Med Biol 1006:225\u2013247. https:\/\/doi.org\/10.1007\/978-4-431-56550-5_13","journal-title":"Adv Exp Med Biol"},{"issue":"12","key":"4536_CR66","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1002\/glia.22886","volume":"63","author":"B Ye","year":"2015","unstructured":"Ye B, Shen H, Zhang J, Zhu YG, Ransom BR, Chen XC, Ye ZC (2015) Dual pathways mediate \u03b2-amyloid stimulated glutathione release from astrocytes. Glia 63(12):2208\u20132219. https:\/\/doi.org\/10.1002\/glia.22886","journal-title":"Glia"},{"key":"4536_CR67","doi-asserted-by":"publisher","first-page":"14474","DOI":"10.1038\/srep14474","volume":"5","author":"L Liu","year":"2015","unstructured":"Liu L, Li CJ, Lu Y, Zong XG, Luo C, Sun J, Guo LJ (2015) Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion. Sci Rep 5:14474. https:\/\/doi.org\/10.1038\/srep14474","journal-title":"Sci Rep"},{"issue":"5","key":"4536_CR68","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/ncb2934","volume":"16","author":"E Bejarano","year":"2014","unstructured":"Bejarano E, Yuste A, Patel B, Stout RF Jr, Spray DC, Cuervo AM (2014) Connexins modulate autophagosome biogenesis. Nat Cell Biol 16(5):401\u2013414. https:\/\/doi.org\/10.1038\/ncb2934","journal-title":"Nat Cell Biol"},{"issue":"7","key":"4536_CR69","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1016\/j.neurobiolaging.2015.04.002","volume":"36","author":"Y Shibuya","year":"2015","unstructured":"Shibuya Y, Niu Z, Bryleva EY, Harris BT, Murphy SR, Kheirollah A, Bowen ZD, Chang CCY et al (2015) Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer\u2019s disease mouse and reduces human P301L-tau content at the presymptomatic stage. Neurobiol Aging 36(7):2248\u20132259. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.04.002","journal-title":"Neurobiol Aging"},{"issue":"3","key":"4536_CR70","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s10616-019-00313-6","volume":"71","author":"X Li","year":"2019","unstructured":"Li X, Song J, Dong R (2019) Cubeben induces autophagy via PI3K-AKT-mTOR pathway to protect primary neurons against amyloid beta in Alzheimer\u2019s disease. Cytotechnology 71(3):679\u2013686. https:\/\/doi.org\/10.1007\/s10616-019-00313-6","journal-title":"Cytotechnology"},{"issue":"3","key":"4536_CR71","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10571-016-0386-8","volume":"37","author":"Q Li","year":"2017","unstructured":"Li Q, Liu Y, Sun M (2017) Autophagy and Alzheimer\u2019s disease. Cell Mol Neurobiol 37(3):377\u2013388. https:\/\/doi.org\/10.1007\/s10571-016-0386-8","journal-title":"Cell Mol Neurobiol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04536-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04536-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04536-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T10:10:55Z","timestamp":1741083055000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04536-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,23]]},"references-count":71,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["4536"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04536-3","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,23]]},"assertion":[{"value":"16 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments with animals were approved by Peking University Shenzhen Hospital and complied with the ethics approval obtained from Peking University Shenzhen Hospital (the specific ethics batch number: 2023\u2013271) as well as the National Institutes of Health Guide for the Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Yes, all the authors have given their consent for the publication of this manuscript in its present form.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}