{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:12:38Z","timestamp":1780632758442,"version":"3.54.1"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004541","name":"MHRD","doi-asserted-by":"crossref","award":["PMRF- 1101578"],"award-info":[{"award-number":["PMRF- 1101578"]}],"id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2020\/002621\/BHS"],"award-info":[{"award-number":["CRG\/2020\/002621\/BHS"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["P-16\/ECD\/Adhoc\/49\/2022-23"],"award-info":[{"award-number":["P-16\/ECD\/Adhoc\/49\/2022-23"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s12035-024-04548-z","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T05:02:16Z","timestamp":1729918936000},"page":"4466-4483","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Focal Adhesion Kinase Inhibition Ameliorates Burn Injury-Induced Chronic Pain in Rats"],"prefix":"10.1007","volume":"62","author":[{"given":"Deepak","family":"Chouhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Akhilesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"4548_CR1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jpain.2007.02.426","volume":"8","author":"GJ Summer","year":"2007","unstructured":"Summer GJ, Puntillo KA, Miaskowski C et al (2007) Burn injury pain: the continuing challenge. J pain 8:533\u2013548","journal-title":"J pain"},{"key":"4548_CR2","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0305-4179(95)00003-8","volume":"21","author":"J Latarjet","year":"1995","unstructured":"Latarjet J, Choinere M (1995) Pain in burn patients. Burns 21:344\u2013348","journal-title":"Burns"},{"key":"4548_CR3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.burns.2016.08.013","volume":"43","author":"C Smolle","year":"2017","unstructured":"Smolle C, Cambiaso-Daniel J, Forbes AA et al (2017) Recent trends in burn epidemiology worldwide: a systematic review. Burns 43:249\u2013257","journal-title":"Burns"},{"key":"4548_CR4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41572-020-0145-5","volume":"6","author":"MG Jeschke","year":"2020","unstructured":"Jeschke MG, van Baar ME, Choudhry MA et al (2020) Burn injury. Nat Rev Dis Prim 6:11","journal-title":"Nat Rev Dis Prim"},{"key":"4548_CR5","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/jbcr\/irz111","volume":"40","author":"DE Kim","year":"2019","unstructured":"Kim DE, Pruskowski KA, Ainsworth CR et al (2019) A review of adjunctive therapies for burn injury pain during the opioid crisis. J Burn Care Res 40:983\u2013995","journal-title":"J Burn Care Res"},{"key":"4548_CR6","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/jbcr\/irad004","volume":"44","author":"DM Hill","year":"2023","unstructured":"Hill DM, DeBoer E (2023) State and future science of opioids and potential of biased-ligand technology in the management of acute pain after burn injury. J Burn Care Res 44:524\u2013534","journal-title":"J Burn Care Res"},{"key":"4548_CR7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.burns.2019.03.028","volume":"46","author":"MA Emery","year":"2020","unstructured":"Emery MA, Eitan S (2020) Drug-specific differences in the ability of opioids to manage burn pain. Burns 46:503\u2013513","journal-title":"Burns"},{"key":"4548_CR8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10555-008-9165-4","volume":"28","author":"J Zhao","year":"2009","unstructured":"Zhao J, Guan J-L (2009) Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev 28:35\u201349","journal-title":"Cancer Metastasis Rev"},{"key":"4548_CR9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrc1647","volume":"5","author":"GW McLean","year":"2005","unstructured":"McLean GW, Carragher NO, Avizienyte E et al (2005) The role of focal-adhesion kinase in cancer\u2014a new therapeutic opportunity. Nat Rev Cancer 5:505\u2013515","journal-title":"Nat Rev Cancer"},{"key":"4548_CR10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijgo.2007.11.019","volume":"101","author":"L Mu","year":"2008","unstructured":"Mu L, Zheng W, Wang L et al (2008) Focal adhesion kinase expression in ovarian endometriosis. Int J Gynecol Obstet 101:161\u2013165","journal-title":"Int J Gynecol Obstet"},{"key":"4548_CR11","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.3892\/etm.2015.2736","volume":"10","author":"L Mu","year":"2015","unstructured":"Mu L, Chen W, Ma Y, Zheng W (2015) Expression of focal adhesion kinase in the eutopic endometrium of women with adenomyosis varies with dysmenorrhea and pelvic pain. Exp Ther Med 10:1903\u20131907","journal-title":"Exp Ther Med"},{"key":"4548_CR12","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.fertnstert.2007.03.060","volume":"89","author":"L Mu","year":"2008","unstructured":"Mu L, Zheng W, Wang L et al (2008) Alteration of focal adhesion kinase expression in eutopic endometrium of women with endometriosis. Fertil Steril 89:529\u2013537","journal-title":"Fertil Steril"},{"key":"4548_CR13","doi-asserted-by":"crossref","first-page":"19276","DOI":"10.1038\/srep19276","volume":"6","author":"X-K Zhao","year":"2016","unstructured":"Zhao X-K, Cheng Y, Liang Cheng M et al (2016) Focal adhesion kinase regulates fibroblast migration via integrin beta-1 and plays a central role in fibrosis. Sci Rep 6:19276","journal-title":"Sci Rep"},{"key":"4548_CR14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nm.2574","volume":"18","author":"VW Wong","year":"2012","unstructured":"Wong VW, Rustad KC, Akaishi S et al (2012) Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Nat Med 18:148\u2013152","journal-title":"Nat Med"},{"key":"4548_CR15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1602\/neurorx.1.1.101","volume":"1","author":"SA Lipton","year":"2004","unstructured":"Lipton SA (2004) Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults. NeuroRx 1:101\u2013110","journal-title":"NeuroRx"},{"key":"4548_CR16","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.nurt.2009.07.008","volume":"6","author":"L-J Wu","year":"2009","unstructured":"Wu L-J, Zhuo M (2009) Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain. Neurotherapeutics 6:693\u2013702","journal-title":"Neurotherapeutics"},{"key":"4548_CR17","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.expneurol.2008.10.018","volume":"215","author":"X-X Qu","year":"2009","unstructured":"Qu X-X, Cai J, Li M-J et al (2009) Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain. Exp Neurol 215:298\u2013307","journal-title":"Exp Neurol"},{"key":"4548_CR18","doi-asserted-by":"crossref","unstructured":"Laumet G, Chen S-R, Pan H-L (2017) NMDA receptors and signaling in chronic neuropathic pain. NMDA Recept 103\u2013119","DOI":"10.1007\/978-3-319-49795-2_6"},{"key":"4548_CR19","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s11064-018-2614-8","volume":"44","author":"X-H Li","year":"2019","unstructured":"Li X-H, Miao H-H, Zhuo M (2019) NMDA receptor dependent long-term potentiation in chronic pain. Neurochem Res 44:531\u2013538","journal-title":"Neurochem Res"},{"key":"4548_CR20","doi-asserted-by":"crossref","unstructured":"Meng Y, Shen HL (2022) Role of N-methyl-D-aspartate receptor NR2B subunit in inflammatory arthritis-induced chronic pain and peripheral sensitized neuropathic pain: a systematic review. J Pain Res 2005\u20132013","DOI":"10.2147\/JPR.S367982"},{"key":"4548_CR21","doi-asserted-by":"publisher","unstructured":"Med CC (2015) \u6c22\u6c14\u548c\u86db\u7f51\u819c\u4e0b\u8154\u51fa\u8840HHS Public Access. 40:1291\u20131296. https:\/\/doi.org\/10.1097\/CCM.0b013e31823da96d.Hydrogen","DOI":"10.1097\/CCM.0b013e31823da96d.Hydrogen"},{"key":"4548_CR22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.expneurol.2008.04.009","volume":"212","author":"MR Detloff","year":"2008","unstructured":"Detloff MR, Fisher LC, McGaughy V et al (2008) Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats. Exp Neurol 212(2):337\u2013347","journal-title":"Exp Neurol"},{"key":"4548_CR23","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.brainresrev.2008.12.010","volume":"60","author":"CE Hulsebosch","year":"2009","unstructured":"Hulsebosch CE, Hains BC, Crown ED, Carlton SM (2009) Mechanisms of chronic central neuropathic pain after spinal cord injury. Brain Res Rev 60:202\u2013213","journal-title":"Brain Res Rev"},{"key":"4548_CR24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejphar.2014.01.057","volume":"728","author":"D Wang","year":"2014","unstructured":"Wang D, Couture R, Hong Y (2014) Activated microglia in the spinal cord underlies diabetic neuropathic pain. Eur J Pharmacol 728:59\u201366","journal-title":"Eur J Pharmacol"},{"key":"4548_CR25","doi-asserted-by":"crossref","first-page":"105222","DOI":"10.1016\/j.jbspin.2021.105222","volume":"88","author":"P Vergne-Salle","year":"2021","unstructured":"Vergne-Salle P, Bertin P (2021) Chronic pain and neuroinflammation. Jt Bone Spine 88:105222","journal-title":"Jt Bone Spine"},{"key":"4548_CR26","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nn1992","volume":"10","author":"J Scholz","year":"2007","unstructured":"Scholz J, Woolf CJ (2007) The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci 10:1361\u20131368","journal-title":"Nat Neurosci"},{"key":"4548_CR27","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.burns.2015.09.007","volume":"41","author":"JE Nyland","year":"2015","unstructured":"Nyland JE, McLean SA, Averitt DL (2015) Prior stress exposure increases pain behaviors in a rat model of full thickness thermal injury. Burns 41:1796\u20131804","journal-title":"Burns"},{"key":"4548_CR28","first-page":"27","volume":"2","author":"J-T Xu","year":"2015","unstructured":"Xu J-T, Sun L, Lutz BM et al (2015) Intrathecal rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain. Transl Perioper pain Med 2:27","journal-title":"Transl Perioper pain Med"},{"key":"4548_CR29","doi-asserted-by":"crossref","first-page":"723395","DOI":"10.3389\/fnmol.2021.723395","volume":"14","author":"J Li","year":"2021","unstructured":"Li J, Chen Y, Liu J et al (2021) Elevated expression and activity of sodium leak channel contributes to neuronal sensitization of inflammatory pain in rats. Front Mol Neurosci 14:723395","journal-title":"Front Mol Neurosci"},{"key":"4548_CR30","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1016\/j.pain.2011.06.008","volume":"152","author":"M De Felice","year":"2011","unstructured":"De Felice M, Sanoja R, Wang R et al (2011) Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain. Pain 152:2701\u20132709","journal-title":"Pain"},{"key":"4548_CR31","doi-asserted-by":"crossref","first-page":"110944","DOI":"10.1016\/j.intimp.2023.110944","volume":"124","author":"A Gadepalli","year":"2023","unstructured":"Gadepalli A, Ummadisetty O, Chouhan D, Tiwari V (2023) Loperamide, a peripheral Mu-Opioid receptor agonist, attenuates chemotherapy-induced neuropathic pain in rats. Int Immunopharmacol 124:110944","journal-title":"Int Immunopharmacol"},{"key":"4548_CR32","doi-asserted-by":"crossref","first-page":"108622","DOI":"10.1016\/j.intimp.2022.108622","volume":"106","author":"A Uniyal","year":"2022","unstructured":"Uniyal A, Rathore AS, Keshri PK et al (2022) Inhibition of pan-Aurora kinase attenuates evoked and ongoing pain in nerve injured rats via regulating KIF17-NR2B mediated signaling. Int Immunopharmacol 106:108622","journal-title":"Int Immunopharmacol"},{"key":"4548_CR33","first-page":"1","volume":"23","author":"J Song","year":"2022","unstructured":"Song J, Cho J, Park J, Hwang JH (2022) Identification and validation of stable reference genes for quantitative real time PCR in different minipig tissues at developmental stages. BMC Genomics 23:1\u201313","journal-title":"BMC Genomics"},{"key":"4548_CR34","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative CT method. Nat Protoc 3:1101\u20131108","journal-title":"Nat Protoc"},{"issue":"2","key":"4548_CR35","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10787-022-00948-6","volume":"30","author":"A Uniyal","year":"2022","unstructured":"Uniyal A, Gadepalli A, Modi A, Tiwari V (2022) Modulation of KIF17\/NR2B crosstalk by tozasertib attenuates inflammatory pain in rats. Inflammopharmacology 30(2):549\u2013563","journal-title":"Inflammopharmacology"},{"key":"4548_CR36","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/01.BCR.0000226019.76946.5D","volume":"27","author":"JC Schneider","year":"2006","unstructured":"Schneider JC, Harris NL, El SA et al (2006) A descriptive review of neuropathic-like pain after burn injury. J Burn care Res 27:524\u2013528","journal-title":"J Burn care Res"},{"key":"4548_CR37","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.burns.2007.05.002","volume":"33","author":"LS Edelman","year":"2007","unstructured":"Edelman LS (2007) Social and economic factors associated with the risk of burn injury. Burns 33:958\u2013965","journal-title":"Burns"},{"key":"4548_CR38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/B978-1-4377-2786-9.00003-5","volume":"4","author":"BA Pruitt","year":"2012","unstructured":"Pruitt BA, Wolf SE, Mason AD (2012) Epidemiological, demographic, and outcome characteristics of burn injury. Total Burn care 4:15\u201345","journal-title":"Total Burn care"},{"key":"4548_CR39","first-page":"129","volume":"8","author":"PL Rice","year":"2021","unstructured":"Rice PL, Orgill D (2021) Assessment and classification of burn injury. UpToDate,[Internet] 8:129\u2013132","journal-title":"UpToDate,[Internet]"},{"key":"4548_CR40","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.burns.2008.01.009","volume":"34","author":"S Monstrey","year":"2008","unstructured":"Monstrey S, Hoeksema H, Verbelen J et al (2008) Assessment of burn depth and burn wound healing potential. Burns 34:761\u2013769","journal-title":"Burns"},{"key":"4548_CR41","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.burns.2017.04.003","volume":"43","author":"NA Martin","year":"2017","unstructured":"Martin NA, Falder S (2017) A review of the evidence for threshold of burn injury. Burns 43:1624\u20131639","journal-title":"Burns"},{"key":"4548_CR42","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.ajem.2015.05.043","volume":"33","author":"AJ Singer","year":"2015","unstructured":"Singer AJ, Beto L, Singer DD et al (2015) Association between burn characteristics and pain severity. Am J Emerg Med 33:1229\u20131231","journal-title":"Am J Emerg Med"},{"key":"4548_CR43","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/WON.0000000000000182","volume":"43","author":"T Taverner","year":"2016","unstructured":"Taverner T, Prince J (2016) Acute neuropathic pain assessment in burn injured patients: a retrospective review. J Wound Ostomy Cont Nurs 43:51\u201355","journal-title":"J Wound Ostomy Cont Nurs"},{"key":"4548_CR44","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/jnr.23551","volume":"93","author":"X Lian","year":"2015","unstructured":"Lian X, Wang X, Wang W et al (2015) Peripheral inflammation activated focal adhesion kinase signaling in spinal dorsal horn of mice. J Neurosci Res 93:873\u2013881","journal-title":"J Neurosci Res"},{"key":"4548_CR45","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1016\/j.celrep.2018.05.075","volume":"24","author":"L Wang","year":"2018","unstructured":"Wang L, Tanaka Y, Wang D et al (2018) The atypical kinesin KIF26A facilitates termination of nociceptive responses by sequestering focal adhesion kinase. Cell Rep 24:2894\u20132907","journal-title":"Cell Rep"},{"key":"4548_CR46","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.neulet.2015.09.031","volume":"607","author":"MM Salas","year":"2015","unstructured":"Salas MM, Mcintyre MK, Petz LN et al (2015) Neuroscience Letters Tetrodotoxin suppresses thermal hyperalgesia and mechanical allodynia in a rat full thickness thermal injury pain model. Neurosci Lett 607:108\u2013113. https:\/\/doi.org\/10.1016\/j.neulet.2015.09.031","journal-title":"Neurosci Lett"},{"key":"4548_CR47","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.burns.2013.10.011","volume":"40","author":"M Fowler","year":"2014","unstructured":"Fowler M, Clifford JL, Garza TH et al (2014) A rat model of full thickness thermal injury characterized by thermal hyperalgesia, mechanical allodynia, pronociceptive peptide release and tramadol analgesia. Burns 40:759\u2013771","journal-title":"Burns"},{"key":"4548_CR48","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0304-3959(98)00070-0","volume":"76","author":"JL Pedersen","year":"1998","unstructured":"Pedersen JL, Kehlet H (1998) Secondary hyperalgesia to heat stimuli after burn injury in man. Pain 76:377\u2013384","journal-title":"Pain"},{"key":"4548_CR49","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1097\/ALN.0000000000000422","volume":"121","author":"M Ueda","year":"2014","unstructured":"Ueda M, Iwasaki H, Wang S et al (2014) Cannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury. Anesthesiology 121:1311\u20131319","journal-title":"Anesthesiology"},{"key":"4548_CR50","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.burns.2007.02.007","volume":"33","author":"GJ Summer","year":"2007","unstructured":"Summer GJ, Dina OA, Levine JD (2007) Enhanced inflammatory hyperalgesia after recovery from burn injury. Burns 33:1021\u20131026","journal-title":"Burns"},{"key":"4548_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnmol.2017.00284","volume":"10","author":"JR Deuis","year":"2017","unstructured":"Deuis JR, Dvorakova LS, Vetter I (2017) Methods used to evaluate pain behaviors in rodents. Front Mol Neurosci 10:1\u201317. https:\/\/doi.org\/10.3389\/fnmol.2017.00284","journal-title":"Front Mol Neurosci"},{"key":"4548_CR52","doi-asserted-by":"crossref","first-page":"e842","DOI":"10.1097\/BCR.0000000000000502","volume":"38","author":"K Zhang","year":"2017","unstructured":"Zhang K, Pei Y, Gan Z et al (2017) Local administration of thiamine ameliorates ongoing pain in a rat model of second-degree burn. J Burn Care Res 38:e842\u2013e850","journal-title":"J Burn Care Res"},{"key":"4548_CR53","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00004630-199505001-00006","volume":"16","author":"MA Ashburn","year":"1995","unstructured":"Ashburn MA (1995) Burn pain: the management of procedure-related pain. J Burn Care Rehabil 16:365\u2013371","journal-title":"J Burn Care Rehabil"},{"key":"4548_CR54","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/ALN.0000000000000993","volume":"124","author":"V Tiwari","year":"2016","unstructured":"Tiwari V, Yang F, He S-Q et al (2016) Activation of peripheral \u03bc-opioid receptors by dermorphin [D-Arg2, Lys4](1\u20134) amide leads to modality-preferred inhibition of neuropathic pain. Anesthesiology 124:706\u2013720","journal-title":"Anesthesiology"},{"key":"4548_CR55","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/j.pain.0000000000001768","volume":"161","author":"V Tiwari","year":"2020","unstructured":"Tiwari V, He S-Q, Huang Q et al (2020) Activation of \u03bc-\u03b4 opioid receptor heteromers inhibits neuropathic pain behavior in rodents. Pain 161:842","journal-title":"Pain"},{"key":"4548_CR56","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1097\/ALN.0000000000002191","volume":"128","author":"V Tiwari","year":"2018","unstructured":"Tiwari V, Anderson M, Yang F et al (2018) Peripherally acting \u03bc-opioid receptor agonists attenuate ongoing pain-associated behavior and spontaneous neuronal activity after nerve injury in rats. Anesthesiology 128:1220\u20131236. https:\/\/doi.org\/10.1097\/ALN.0000000000002191","journal-title":"Anesthesiology"},{"key":"4548_CR57","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/s41467-021-21173-9","volume":"12","author":"H Wu","year":"2021","unstructured":"Wu H, Petitpr\u00e9 C, Fontanet P et al (2021) Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice. Nat Commun 12:1026","journal-title":"Nat Commun"},{"key":"4548_CR58","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41467-019-13839-2","volume":"11","author":"X Yu","year":"2020","unstructured":"Yu X, Liu H, Hamel KA et al (2020) Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. Nat Commun 11:264","journal-title":"Nat Commun"},{"key":"4548_CR59","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1038\/s41467-019-11158-0","volume":"10","author":"C Chen","year":"2019","unstructured":"Chen C, Zhang J, Sun L et al (2019) Long-term imaging of dorsal root ganglia in awake behaving mice. Nat Commun 10:3087","journal-title":"Nat Commun"},{"key":"4548_CR60","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41467-023-36014-0","volume":"14","author":"M Jung","year":"2023","unstructured":"Jung M, Dourado M, Maksymetz J et al (2023) Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function. Nat Commun 14:366","journal-title":"Nat Commun"},{"key":"4548_CR61","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0306-4522(00)00419-X","volume":"101","author":"Q-P Ma","year":"2000","unstructured":"Ma Q-P, Hargreaves RJ (2000) Localization of N-methyl-D-aspartate NR2B subunits on primary sensory neurons that give rise to small-caliber sciatic nerve fibers in rats. Neuroscience 101:699\u2013707","journal-title":"Neuroscience"},{"key":"4548_CR62","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1038\/s41386-018-0115-8","volume":"43","author":"X-B Wu","year":"2018","unstructured":"Wu X-B, Jing P-B, Zhang Z-J et al (2018) Chemokine receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell. Neuropsychopharmacology 43:2320\u20132330","journal-title":"Neuropsychopharmacology"},{"key":"4548_CR63","doi-asserted-by":"crossref","first-page":"e0201021","DOI":"10.1371\/journal.pone.0201021","volume":"13","author":"Y Xu","year":"2018","unstructured":"Xu Y, Zhang K, Miao J et al (2018) The spinal NR2BR\/ERK2 pathway as a target for the central sensitization of collagen-induced arthritis pain. PLoS ONE 13:e0201021","journal-title":"PLoS ONE"},{"key":"4548_CR64","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1007\/s12264-020-00557-9","volume":"36","author":"H Zhang","year":"2020","unstructured":"Zhang H, Ma S-B, Gao Y-J et al (2020) Spinal CCL2 promotes pain sensitization by rapid enhancement of NMDA-induced currents through the ERK-GluN2B pathway in mouse lamina II neurons. Neurosci Bull 36:1344\u20131354","journal-title":"Neurosci Bull"},{"key":"4548_CR65","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1523\/JNEUROSCI.1161-14.2015","volume":"35","author":"J-X Yang","year":"2015","unstructured":"Yang J-X, Hua L, Li Y-Q et al (2015) Caveolin-1 in the anterior cingulate cortex modulates chronic neuropathic pain via regulation of NMDA receptor 2B subunit. J Neurosci 35:36\u201352","journal-title":"J Neurosci"},{"key":"4548_CR66","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00702-020-02161-7","volume":"127","author":"K Messlinger","year":"2020","unstructured":"Messlinger K, Balcziak LK, Russo AF (2020) Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators. J Neural Transm 127:431\u2013444","journal-title":"J Neural Transm"},{"key":"4548_CR67","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0304-3940(91)90339-U","volume":"131","author":"TJ Coderre","year":"1991","unstructured":"Coderre TJ, Melzack R (1991) Central neural mediators of secondary hyperalgesia following heat injury in rats: neuropeptides and excitatory amino acids. Neurosci Lett 131:71\u201374","journal-title":"Neurosci Lett"},{"key":"4548_CR68","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuroscience.2007.11.037","volume":"152","author":"A Nazarian","year":"2008","unstructured":"Nazarian A, Gu G, Gracias NG et al (2008) Spinal N-methyl-D-aspartate receptors and nociception-evoked release of primary afferent substance P. Neuroscience 152:119\u2013127","journal-title":"Neuroscience"},{"key":"4548_CR69","doi-asserted-by":"crossref","first-page":"e15162","DOI":"10.1371\/journal.pone.0015162","volume":"5","author":"A Brand","year":"2010","unstructured":"Brand A, Smith ESJ, Lewin GR, Park TJ (2010) Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat. PLoS ONE 5:e15162","journal-title":"PLoS ONE"},{"key":"4548_CR70","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1053\/gast.2001.24848","volume":"120","author":"JA McRoberts","year":"2001","unstructured":"McRoberts JA, Coutinho SV, Marviz\u00f3n JCG et al (2001) Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats. Gastroenterology 120:1737\u20131748","journal-title":"Gastroenterology"},{"key":"4548_CR71","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.neuroscience.2009.03.016","volume":"160","author":"W Xie","year":"2009","unstructured":"Xie W, Strong JA, Zhang J-M (2009) Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models. Neuroscience 160:847\u2013857","journal-title":"Neuroscience"},{"key":"4548_CR72","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1533-2500.2010.00367.x","volume":"10","author":"R Vallejo","year":"2010","unstructured":"Vallejo R, Tilley DM, Vogel L, Benyamin R (2010) The role of glia and the immune system in the development and maintenance of neuropathic pain. Pain Pract 10:167\u2013184","journal-title":"Pain Pract"},{"key":"4548_CR73","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuroscience.2015.09.036","volume":"310","author":"W-W Li","year":"2015","unstructured":"Li W-W, Guo T-Z, Shi X et al (2015) Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture. Neuroscience 310:73\u201390","journal-title":"Neuroscience"},{"key":"4548_CR74","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.1038\/s41467-021-27038-5","volume":"12","author":"G Ryzhakov","year":"2021","unstructured":"Ryzhakov G, Almuttaqi H, Corbin AL et al (2021) Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation. Nat Commun 12:6702","journal-title":"Nat Commun"},{"key":"4548_CR75","first-page":"1744","volume":"4","author":"F Zhang","year":"2008","unstructured":"Zhang F, Vadakkan KI, Kim SS et al (2008) Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse. Mol Pain 4:1744\u20138069","journal-title":"Mol Pain"},{"key":"4548_CR76","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1002\/jnr.25199","volume":"101","author":"P Pahan","year":"2023","unstructured":"Pahan P, Xie JY (2023) Microglial inflammation modulates opioid analgesic tolerance. J Neurosci Res 101:1383\u20131392. https:\/\/doi.org\/10.1002\/jnr.25199","journal-title":"J Neurosci Res"},{"key":"4548_CR77","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/glia.22379","volume":"61","author":"M Tsuda","year":"2013","unstructured":"Tsuda M, Beggs S, Salter MW, Inoue K (2013) Microglia and intractable chronic pain. Glia 61:55\u201361","journal-title":"Glia"},{"key":"4548_CR78","first-page":"1","volume":"7","author":"J Peng","year":"2016","unstructured":"Peng J, Gu N, Zhou L et al (2016) Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury. Nat Commun 7:1\u201313","journal-title":"Nat Commun"},{"key":"4548_CR79","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1016\/j.celrep.2019.10.085","volume":"29","author":"H Luo","year":"2019","unstructured":"Luo H, Liu H-Z, Zhang W-W et al (2019) Interleukin-17 regulates neuron-glial communications, synaptic transmission, and neuropathic pain after chemotherapy. Cell Rep 29:2384\u20132397","journal-title":"Cell Rep"},{"key":"4548_CR80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/cc10617","volume":"16","author":"A Alexis","year":"2012","unstructured":"Alexis A, Carrer D, Pistiki A et al (2012) Apoptosis of neutrophils, expression of TREM-1 on neutrophils and IL-17 responses in experimental burn in injury are related to the type and time of burn exposure. Crit Care 16:1\u2013189","journal-title":"Crit Care"},{"key":"4548_CR81","first-page":"681","volume":"70","author":"CJ Neely","year":"2011","unstructured":"Neely CJ, Maile R, Wang M-J et al (2011) Th17 (IFN\u03b3\u2212 IL17+) CD4+ T cells generated after burn injury may be a novel cellular mechanism for postburn immunosuppression. J Trauma 70:681","journal-title":"J Trauma"},{"key":"4548_CR82","doi-asserted-by":"crossref","first-page":"999407","DOI":"10.3389\/fimmu.2022.999407","volume":"13","author":"X Jiang","year":"2022","unstructured":"Jiang X, Zhou R, Zhang Y et al (2022) Interleukin-17 as a potential therapeutic target for chronic pain. Front Immunol 13:999407","journal-title":"Front Immunol"},{"key":"4548_CR83","doi-asserted-by":"crossref","first-page":"578068","DOI":"10.1016\/j.jneuroim.2023.578068","volume":"377","author":"J-L Sun","year":"2023","unstructured":"Sun J-L, Dai W-J, Shen X-Y et al (2023) Interleukin-17 is involved in neuropathic pain and spinal synapse plasticity on mice. J Neuroimmunol 377:578068","journal-title":"J Neuroimmunol"},{"key":"4548_CR84","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3892\/mmr.2016.6018","volume":"15","author":"C Sun","year":"2017","unstructured":"Sun C, Zhang J, Chen L et al (2017) IL-17 contributed to the neuropathic pain following peripheral nerve injury by promoting astrocyte proliferation and secretion of proinflammatory cytokines. Mol Med Rep 15:89\u201396","journal-title":"Mol Med Rep"},{"key":"4548_CR85","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1213\/ANE.0000000000005274","volume":"132","author":"Y Zhou","year":"2021","unstructured":"Zhou Y, Leung-Pitt Y, Deng H et al (2021) Non-opioid, GTS-21 mitigates burn injury pain in rats by decreasing spinal cord inflammatory responses. Anesth Analg 132:240","journal-title":"Anesth Analg"},{"key":"4548_CR86","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1590\/s0102-865020180070000007","volume":"33","author":"C Liu","year":"2018","unstructured":"Liu C, Zhang F, Liu H, Wei F (2018) NF-kB mediated CX3CL1 activation in the dorsal root ganglion contributes to the maintenance of neuropathic pain induced in adult male Sprague Dawley rats. Acta Cir Bras 33:619\u2013628","journal-title":"Acta Cir Bras"},{"key":"4548_CR87","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3390\/ph14040307","volume":"14","author":"SY Alomar","year":"2021","unstructured":"Alomar SY, El GREA, Enan ET et al (2021) Novel mechanism for memantine in attenuating diabetic neuropathic pain in mice via downregulating the spinal HMGB1\/TRL4\/NF-kB inflammatory axis. Pharmaceuticals 14:307","journal-title":"Pharmaceuticals"},{"key":"4548_CR88","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1111\/j.0953-816X.2004.03441.x","volume":"19","author":"K Lee","year":"2004","unstructured":"Lee K, Kang B, Lee H et al (2004) Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity. Eur J Neurosci 19:3375\u20133381","journal-title":"Eur J Neurosci"},{"key":"4548_CR89","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1365-4632.2012.05703.x","volume":"52","author":"MCY Heng","year":"2013","unstructured":"Heng MCY (2013) Signaling pathways targeted by curcumin in acute and chronic injury: burns and photo-damaged skin. Int J Dermatol 52:531\u2013543","journal-title":"Int J Dermatol"},{"key":"4548_CR90","first-page":"721","volume":"73","author":"Q Ma","year":"2018","unstructured":"Ma Q, Wu Y-S, Shen J-Y et al (2018) Walnut oil promotes healing of wounds and skin defects in rats via regulating the NF-kB pathway. Die Pharm Int J Pharm Sci 73:721\u2013724","journal-title":"Die Pharm Int J Pharm Sci"},{"key":"4548_CR91","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/jbio.201400058","volume":"8","author":"A Gupta","year":"2015","unstructured":"Gupta A, Keshri GK, Yadav A et al (2015) Superpulsed (Ga-As, 904 nm) low-level laser therapy (LLLT) attenuates inflammatory response and enhances healing of burn wounds. J Biophotonics 8:489\u2013501","journal-title":"J Biophotonics"},{"key":"4548_CR92","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.biopha.2016.12.049","volume":"86","author":"MG Rahbardar","year":"2017","unstructured":"Rahbardar MG, Amin B, Mehri S et al (2017) Anti-inflammatory effects of ethanolic extract of Rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic pain. Biomed Pharmacother 86:441\u2013449","journal-title":"Biomed Pharmacother"},{"key":"4548_CR93","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejphar.2011.04.014","volume":"661","author":"K Pabreja","year":"2011","unstructured":"Pabreja K, Dua K, Sharma S et al (2011) Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms. Eur J Pharmacol 661:15\u201321","journal-title":"Eur J Pharmacol"},{"key":"4548_CR94","first-page":"9347696","volume":"2018","author":"G-L Jin","year":"2018","unstructured":"Jin G-L, He S-D, Lin S-M et al (2018) Koumine attenuates neuroglia activation and inflammatory response to neuropathic pain. Neural Plast 2018:9347696","journal-title":"Neural Plast"},{"key":"4548_CR95","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1007\/s10753-013-9688-x","volume":"36","author":"NN Pathak","year":"2013","unstructured":"Pathak NN, Balaganur V, Lingaraju MC et al (2013) Antihyperalgesic and anti-inflammatory effects of atorvastatin in chronic constriction injury-induced neuropathic pain in rats. Inflammation 36:1468\u20131478","journal-title":"Inflammation"},{"key":"4548_CR96","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neulet.2008.03.050","volume":"437","author":"N \u00dc\u00e7eyler","year":"2008","unstructured":"\u00dc\u00e7eyler N, Sommer C (2008) Cytokine regulation in animal models of neuropathic pain and in human diseases. Neurosci Lett 437:194\u2013198","journal-title":"Neurosci Lett"},{"key":"4548_CR97","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.neuropharm.2011.10.002","volume":"62","author":"KABS da Silva","year":"2012","unstructured":"da Silva KABS, Manjavachi MN, Paszcuk AF et al (2012) Plant derived alkaloid (\u2212)-cassine induces anti-inflammatory and anti-hyperalgesics effects in both acute and chronic inflammatory and neuropathic pain models. Neuropharmacology 62:967\u2013977","journal-title":"Neuropharmacology"},{"key":"4548_CR98","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.3390\/biomedicines10112847","volume":"10","author":"G Amodeo","year":"2022","unstructured":"Amodeo G, Franchi S, Galimberti G et al (2022) Osteoarthritis pain in old mice aggravates neuroinflammation and frailty: the positive effect of morphine treatment. Biomedicines 10:2847","journal-title":"Biomedicines"},{"key":"4548_CR99","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.0300-9475.2004.01396.x","volume":"59","author":"Z Pourpak","year":"2004","unstructured":"Pourpak Z, Ahmadiani A, Alebouyeh M (2004) Involvement of interleukin-1\u03b2 in systemic morphine effects on paw oedema in a mouse model of acute inflammation. Scand J Immunol 59:273\u2013277","journal-title":"Scand J Immunol"},{"key":"4548_CR100","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1186\/1744-8069-3-28","volume":"3","author":"JD Clark","year":"2007","unstructured":"Clark JD, Shi X, Li X et al (2007) Morphine reduces local cytokine expression and neutrophil infiltration after incision. Mol Pain 3:1744\u20138069","journal-title":"Mol Pain"},{"key":"4548_CR101","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1213\/ANE.0000000000000020","volume":"117","author":"C-P Yang","year":"2013","unstructured":"Yang C-P, Cherng C-H, Wu C-T et al (2013) Intrathecal ultra-low dose naloxone enhances the antihyperalgesic effects of morphine and attenuates tumor necrosis factor-\u03b1 and tumor necrosis factor-\u03b1 receptor 1 expression in the dorsal horn of rats with partial sciatic nerve transection. Anesth Analg 117:1493\u20131502","journal-title":"Anesth Analg"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04548-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04548-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04548-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T10:10:29Z","timestamp":1741083029000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04548-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,26]]},"references-count":101,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["4548"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04548-z","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,26]]},"assertion":[{"value":"5 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The behavioral experiments were conducted as per the guidelines approved by the International Association for the Study of Pain and the Committee for Control and Supervision of Experiments on Animals (CCSEA), as provided by the Government of India, New Delhi. The Animal Ethical Committee of the Indian Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh, India, approved the experimental protocols (IIT(BHU)\/IAEC\/2022\/015).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}