{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T01:51:37Z","timestamp":1772329897203,"version":"3.50.1"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Project for Academic and Technical Leaders of Major Disciplines in Jiangxi Province","award":["20213BCJL22049"],"award-info":[{"award-number":["20213BCJL22049"]}]},{"name":"the Innovative Research Groups of Hubei Province","award":["2022CFA026"],"award-info":[{"award-number":["2022CFA026"]}]},{"name":"the National Key Research and Development Program of China","award":["2019YFE0115900"],"award-info":[{"award-number":["2019YFE0115900"]}]},{"name":"the New 20 Terms of Universities in Jinan","award":["202228022"],"award-info":[{"award-number":["202228022"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s12035-024-04561-2","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T02:02:29Z","timestamp":1730167349000},"page":"4605-4616","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Complement Receptor 1 Is a Potential Extracerebral Factor Promoting \u03b1-Synuclein Pathology"],"prefix":"10.1007","volume":"62","author":[{"given":"Yunying","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sichun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhentao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"issue":"5","key":"4561_CR1","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1474-4422(18)30499-X","volume":"18","author":"Collaborators GN","year":"2019","unstructured":"Collaborators GN (2019) Global, regional, and national burden of neurological disorders, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 18(5):459\u2013480. https:\/\/doi.org\/10.1016\/S1474-4422(18)30499-X","journal-title":"Lancet Neurol"},{"key":"4561_CR2","doi-asserted-by":"publisher","unstructured":"Parkinson J (2002) An essay on the shaking palsy. 1817. J Neuropsychiatry Clin Neurosci 14(2):223\u2013236. https:\/\/doi.org\/10.1176\/jnp.14.2.223","DOI":"10.1176\/jnp.14.2.223"},{"issue":"5","key":"4561_CR3","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","volume":"20","author":"E Tolosa","year":"2021","unstructured":"Tolosa E, Garrido A, Scholz SW, Poewe W (2021) Challenges in the diagnosis of Parkinson\u2019s disease. Lancet Neurol 20(5):385\u2013397. https:\/\/doi.org\/10.1016\/S1474-4422(21)00030-2","journal-title":"Lancet Neurol"},{"issue":"10291","key":"4561_CR4","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","volume":"397","author":"BR Bloem","year":"2021","unstructured":"Bloem BR, Okun MS, Klein C (2021) Parkinson\u2019s disease. Lancet 397(10291):2284\u20132303. https:\/\/doi.org\/10.1016\/S0140-6736(21)00218-X","journal-title":"Lancet"},{"issue":"7933","key":"4561_CR5","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/s41586-022-05319-3","volume":"610","author":"Y Yang","year":"2022","unstructured":"Yang Y, Shi Y, Schweighauser M, Zhang X, Kotecha A, Murzin AG, Garringer HJ, Cullinane PW et al (2022) Structures of \u03b1-synuclein filaments from human brains with Lewy pathology. Nature 610(7933):791\u2013795. https:\/\/doi.org\/10.1038\/s41586-022-05319-3","journal-title":"Nature"},{"issue":"2","key":"4561_CR6","doi-asserted-by":"publisher","first-page":"10","DOI":"10.20517\/and.2023.05","volume":"3","author":"C Kang","year":"2023","unstructured":"Kang C, Yu-Jie G, Peng L, David IF (2023) Can alpha-synuclein be both the cause and a consequence of Parkinson\u2019s disease? Ageing Neurodegener Dis 3(2):10. https:\/\/doi.org\/10.20517\/and.2023.05","journal-title":"Ageing Neurodegener Dis"},{"issue":"2","key":"4561_CR7","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/S1474-4422(19)30287-X","volume":"19","author":"C Blauwendraat","year":"2020","unstructured":"Blauwendraat C, Nalls MA, Singleton AB (2020) The genetic architecture of Parkinson\u2019s disease. Lancet Neurol 19(2):170\u2013178. https:\/\/doi.org\/10.1016\/S1474-4422(19)30287-X","journal-title":"Lancet Neurol"},{"key":"4561_CR8","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.addr.2018.04.009","volume":"135","author":"Y Pan","year":"2018","unstructured":"Pan Y, Nicolazzo JA (2018) Impact of aging, Alzheimer\u2019s disease and Parkinson\u2019s disease on the blood-brain barrier transport of therapeutics. Adv Drug Deliv Rev 135:62\u201374. https:\/\/doi.org\/10.1016\/j.addr.2018.04.009","journal-title":"Adv Drug Deliv Rev"},{"issue":"12","key":"4561_CR9","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1038\/81834\/nn1200_1301","volume":"3","author":"R Betarbet","year":"2000","unstructured":"Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT (2000) Chronic systemic pesticide exposure reproduces features of Parkinson\u2019s disease. Nat Neurosci 3(12):1301\u20131306. https:\/\/doi.org\/10.1038\/81834\/nn1200_1301","journal-title":"Nat Neurosci"},{"issue":"1","key":"4561_CR10","doi-asserted-by":"publisher","first-page":"5","DOI":"10.20517\/and.2023.36","volume":"4","author":"B Jonas","year":"2024","unstructured":"Jonas B, Anika F, Heinz R (2024) Aging and Parkinson\u2019s disease: a complex interplay of vulnerable neurons, the immune system and the blood-brain barrier. Ageing Neurodegener Dis 4(1):5. https:\/\/doi.org\/10.20517\/and.2023.36","journal-title":"Ageing Neurodegener Dis"},{"issue":"7794","key":"4561_CR11","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/s41586-020-1984-7","volume":"578","author":"M Shahnawaz","year":"2020","unstructured":"Shahnawaz M, Mukherjee A, Pritzkow S, Mendez N, Rabadia P, Liu X, Hu B, Schmeichel A et al (2020) Discriminating \u03b1-synuclein strains in Parkinson\u2019s disease and multiple system atrophy. Nature 578(7794):273\u2013277. https:\/\/doi.org\/10.1038\/s41586-020-1984-7","journal-title":"Nature"},{"issue":"7626","key":"4561_CR12","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1038\/538S13a","volume":"538","author":"S Makin","year":"2016","unstructured":"Makin S (2016) Pathology: the prion principle. Nature 538(7626):S13\u2013S16. https:\/\/doi.org\/10.1038\/538S13a","journal-title":"Nature"},{"issue":"1","key":"4561_CR13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13024-022-00560-w","volume":"17","author":"K Chen","year":"2022","unstructured":"Chen K, Martens YA, Meneses A, Ryu DH, Lu W, Raulin AC, Li F, Zhao J et al (2022) LRP1 is a neuronal receptor for \u03b1-synuclein uptake and spread. Mol Neurodegener 17(1):57. https:\/\/doi.org\/10.1186\/s13024-022-00560-w","journal-title":"Mol Neurodegener"},{"issue":"9","key":"4561_CR14","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1038\/nprot.2014.143","volume":"9","author":"LA Volpicelli-Daley","year":"2014","unstructured":"Volpicelli-Daley LA, Luk KC, Lee VMY (2014) Addition of exogenous \u03b1-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous \u03b1-synuclein to Lewy body and Lewy neurite-like aggregates. Nat Protoc 9(9):2135\u20132146. https:\/\/doi.org\/10.1038\/nprot.2014.143","journal-title":"Nat Protoc"},{"issue":"3","key":"4561_CR15","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1111\/jnc.15461","volume":"159","author":"K Dauer N\u00e9e Joppe","year":"2021","unstructured":"Dauer N\u00e9e Joppe K, Tatenhorst L, Caldi Gomes L, Zhang S, Parvaz M, Carboni E, Roser A-E, El DeBakey H et al (2021) Brain iron enrichment attenuates \u03b1-synuclein spreading after injection of preformed fibrils. J Neurochem 159(3):554\u2013573. https:\/\/doi.org\/10.1111\/jnc.15461","journal-title":"J Neurochem"},{"issue":"2","key":"4561_CR16","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/ncb748","volume":"4","author":"H Fujiwara","year":"2002","unstructured":"Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K et al (2002) alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4(2):160\u2013164","journal-title":"Nat Cell Biol"},{"issue":"15","key":"4561_CR17","doi-asserted-by":"publisher","first-page":"e2109617119","DOI":"10.1073\/pnas.2109617119","volume":"119","author":"SS Ghanem","year":"2022","unstructured":"Ghanem SS, Majbour NK, Vaikath NN, Ardah MT, Erskine D, Jensen NM, Fayyad M, Sudhakaran IP et al (2022) \u03b1-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity. Proc Natl Acad Sci U S A 119(15):e2109617119. https:\/\/doi.org\/10.1073\/pnas.2109617119","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4561_CR18","doi-asserted-by":"publisher","unstructured":"Zhang S, Liu Y-Q, Jia C, Lim Y-J, Feng G, Xu E, Long H, Kimura Y et al (2021) Mechanistic basis for receptor-mediated pathological \u03b1-synuclein fibril cell-to-cell transmission in Parkinson's disease. Proc Natl Acad Sci USA 118(26):e2011196118. https:\/\/doi.org\/10.1073\/pnas.2011196118","DOI":"10.1073\/pnas.2011196118"},{"issue":"1","key":"4561_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1001\/jamaneurol.2020.3311","volume":"78","author":"Z Wang","year":"2020","unstructured":"Wang Z, Becker K, Donadio V, Siedlak S, Yuan J, Rezaee M, Incensi A, Kuzkina A et al (2020) Skin \u03b1-synuclein aggregation seeding activity as a novel biomarker for Parkinson disease. JAMA Neurol 78(1):1\u201311. https:\/\/doi.org\/10.1001\/jamaneurol.2020.3311","journal-title":"JAMA Neurol"},{"issue":"10","key":"4561_CR20","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1002\/mds.26307","volume":"30","author":"A Keshavarzian","year":"2015","unstructured":"Keshavarzian A, Green SJ, Engen PA, Voigt RM, Naqib A, Forsyth CB, Mutlu E, Shannon KM (2015) Colonic bacterial composition in Parkinson\u2019s disease. Mov Disord 30(10):1351\u20131360. https:\/\/doi.org\/10.1002\/mds.26307","journal-title":"Mov Disord"},{"issue":"7","key":"4561_CR21","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/S1474-4422(16)00080-6","volume":"15","author":"D Vilas","year":"2016","unstructured":"Vilas D, Iranzo A, Tolosa E, Aldecoa I, Berenguer J, Vilaseca I, Mart\u00ed C, Serradell M et al (2016) Assessment of \u03b1-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study. Lancet Neurol 15(7):708\u2013718. https:\/\/doi.org\/10.1016\/S1474-4422(16)00080-6","journal-title":"Lancet Neurol"},{"issue":"3","key":"4561_CR22","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S1474-4422(20)30449-X","volume":"20","author":"A Iranzo","year":"2021","unstructured":"Iranzo A, Fairfoul G, Ayudhaya ACN, Serradell M, Gelpi E, Vilaseca I, Sanchez-Valle R, Gaig C et al (2021) Detection of \u03b1-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study. Lancet Neurol 20(3):203\u2013212. https:\/\/doi.org\/10.1016\/S1474-4422(20)30449-X","journal-title":"Lancet Neurol"},{"issue":"9","key":"4561_CR23","doi-asserted-by":"publisher","first-page":"3058","DOI":"10.1093\/brain\/awac115","volume":"145","author":"A Kluge","year":"2022","unstructured":"Kluge A, Bunk J, Schaeffer E, Drobny A, Xiang W, Knacke H, Bub S, L\u00fcckst\u00e4dt W et al (2022) Detection of neuron-derived pathological \u03b1-synuclein in blood. Brain 145(9):3058\u20133071. https:\/\/doi.org\/10.1093\/brain\/awac115","journal-title":"Brain"},{"issue":"7556","key":"4561_CR24","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/nature14547","volume":"522","author":"W Peelaerts","year":"2015","unstructured":"Peelaerts W, Bousset L, Van der Perren A, Moskalyuk A, Pulizzi R, Giugliano M, Van den Haute C, Melki R et al (2015) \u03b1-Synuclein strains cause distinct synucleinopathies after local and systemic administration. Nature 522(7556):340\u2013344. https:\/\/doi.org\/10.1038\/nature14547","journal-title":"Nature"},{"issue":"2","key":"4561_CR25","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1159\/000112832","volume":"5","author":"R Barbour","year":"2008","unstructured":"Barbour R, Kling K, Anderson JP, Banducci K, Cole T, Diep L, Fox M, Goldstein JM et al (2008) Red blood cells are the major source of alpha-synuclein in blood. Neurodegener Dis 5(2):55\u201359. https:\/\/doi.org\/10.1159\/000112832","journal-title":"Neurodegener Dis"},{"issue":"1","key":"4561_CR26","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s40478-017-0470-4","volume":"5","author":"J Matsumoto","year":"2017","unstructured":"Matsumoto J, Stewart T, Sheng L, Li N, Bullock K, Song N, Shi M, Banks WA et al (2017) Transmission of \u03b1-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson\u2019s disease? Acta Neuropathol Commun 5(1):71. https:\/\/doi.org\/10.1186\/s40478-017-0470-4","journal-title":"Acta Neuropathol Commun"},{"key":"4561_CR27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.neulet.2018.04.042","volume":"677","author":"L Fang","year":"2018","unstructured":"Fang L, Tang B-S, Fan K, Wan C-M, Yan X-X, Guo J-F (2018) Alzheimer\u2019s disease susceptibility genes modify the risk of Parkinson disease and Parkinson\u2019s disease-associated cognitive impairment. Neurosci Lett 677:55\u201359. https:\/\/doi.org\/10.1016\/j.neulet.2018.04.042","journal-title":"Neurosci Lett"},{"issue":"3","key":"4561_CR28","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1002\/ana.22277","volume":"69","author":"LB Chibnik","year":"2011","unstructured":"Chibnik LB, Shulman JM, Leurgans SE, Schneider JA, Wilson RS, Tran D, Aubin C, Buchman AS et al (2011) CR1 is associated with amyloid plaque burden and age-related cognitive decline. Ann Neurol 69(3):560\u2013569. https:\/\/doi.org\/10.1002\/ana.22277","journal-title":"Ann Neurol"},{"key":"4561_CR29","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jneuroim.2008.06.019","volume":"201\u2013202","author":"L Soreq","year":"2008","unstructured":"Soreq L, Israel Z, Bergman H, Soreq H (2008) Advanced microarray analysis highlights modified neuro-immune signaling in nucleated blood cells from Parkinson\u2019s disease patients. J Neuroimmunol 201\u2013202:227\u2013236. https:\/\/doi.org\/10.1016\/j.jneuroim.2008.06.019","journal-title":"J Neuroimmunol"},{"issue":"3","key":"4561_CR30","doi-asserted-by":"publisher","first-page":"899","DOI":"10.4049\/jimmunol.140.3.899","volume":"140","author":"JA Schifferli","year":"1988","unstructured":"Schifferli JA, Ng YC, Estreicher J, Walport MJ (1988) The clearance of tetanus toxoid\/anti-tetanus toxoid immune complexes from the circulation of humans. Complement- and erythrocyte complement receptor 1-dependent mechanisms. J Immunol 140(3):899\u2013904","journal-title":"J Immunol"},{"issue":"2","key":"4561_CR31","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1093\/infdis\/170.2.429","volume":"170","author":"DC Montefiori","year":"1994","unstructured":"Montefiori DC, Graham BS, Zhou JY, Zhou JT, Ahearn JM (1994) Binding of human immunodeficiency virus type 1 to the C3b\/C4b receptor CR1 (CD35) and red blood cells in the presence of envelope-specific antibodies and complement. National Institutes of Health AIDS Vaccine Clinical Trials Networks. J Infect Dis 170(2):429\u2013432","journal-title":"J Infect Dis"},{"issue":"11","key":"4561_CR32","doi-asserted-by":"publisher","first-page":"6214","DOI":"10.4049\/jimmunol.151.11.6214","volume":"151","author":"DP Vik","year":"1993","unstructured":"Vik DP, Wong WW (1993) Structure of the gene for the F allele of complement receptor type 1 and sequence of the coding region unique to the S allele. J Immunol 151(11):6214\u20136224","journal-title":"J Immunol"},{"issue":"6","key":"4561_CR33","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/S0092-8674(02)00672-4","volume":"108","author":"BO Smith","year":"2002","unstructured":"Smith BO, Mallin RL, Krych-Goldberg M, Wang X, Hauhart RE, Bromek K, Uhrin D, Atkinson JP et al (2002) Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor. Cell 108(6):769\u2013780","journal-title":"Cell"},{"issue":"11","key":"4561_CR34","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1002\/eji.1830241123","volume":"24","author":"C Danielsson","year":"1994","unstructured":"Danielsson C, Pascual M, French L, Steiger G, Schifferli JA (1994) Soluble complement receptor type 1 (CD35) is released from leukocytes by surface cleavage. Eur J Immunol 24(11):2725\u20132731","journal-title":"Eur J Immunol"},{"key":"4561_CR35","doi-asserted-by":"publisher","first-page":"100200","DOI":"10.1074\/jbc.RA120.016127","volume":"296","author":"S Wymann","year":"2021","unstructured":"Wymann S, Dai Y, Nair AG, Cao H, Powers GA, Schnell A, Martin-Roussety G, Leong D et al (2021) A novel soluble complement receptor 1 fragment with enhanced therapeutic potential. J Biol Chem 296:100200. https:\/\/doi.org\/10.1074\/jbc.RA120.016127","journal-title":"J Biol Chem"},{"issue":"5","key":"4561_CR36","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.molimm.2008.09.026","volume":"46","author":"R Khera","year":"2009","unstructured":"Khera R, Das N (2009) Complement Receptor 1: disease associations and therapeutic implications. Mol Immunol 46(5):761\u2013772. https:\/\/doi.org\/10.1016\/j.molimm.2008.09.026","journal-title":"Mol Immunol"},{"issue":"5","key":"4561_CR37","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1084\/jem.168.5.1699","volume":"168","author":"LB Klickstein","year":"1988","unstructured":"Klickstein LB, Bartow TJ, Miletic V, Rabson LD, Smith JA, Fearon DT (1988) Identification of distinct C3b and C4b recognition sites in the human C3b\/C4b receptor (CR1, CD35) by deletion mutagenesis. J Exp Med 168(5):1699\u20131717","journal-title":"J Exp Med"},{"issue":"1","key":"4561_CR38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0014-5793(94)00395-5","volume":"345","author":"R Jakes","year":"1994","unstructured":"Jakes R, Spillantini MG, Goedert M (1994) Identification of two distinct synucleins from human brain. FEBS Lett 345(1):27\u201332","journal-title":"FEBS Lett"},{"key":"4561_CR39","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s40035-019-0155-y","volume":"8","author":"C Tian","year":"2019","unstructured":"Tian C, Liu G, Gao L, Soltys D, Pan C, Stewart T, Shi M, Xie Z et al (2019) Erythrocytic \u03b1-Synuclein as a potential biomarker for Parkinson\u2019s disease. Transl Neurodegener 8:15. https:\/\/doi.org\/10.1186\/s40035-019-0155-y","journal-title":"Transl Neurodegener"},{"issue":"9","key":"4561_CR40","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/s41422-018-0075-x","volume":"28","author":"Y Li","year":"2018","unstructured":"Li Y, Zhao C, Luo F, Liu Z, Gui X, Luo Z, Zhang X, Li D et al (2018) Amyloid fibril structure of \u03b1-synuclein determined by cryo-electron microscopy. Cell Res 28(9):897\u2013903. https:\/\/doi.org\/10.1038\/s41422-018-0075-x","journal-title":"Cell Res"},{"key":"4561_CR41","doi-asserted-by":"publisher","first-page":"8740419","DOI":"10.1155\/2020\/8740419","volume":"2020","author":"X-Y Li","year":"2020","unstructured":"Li X-Y, Yang W, Li X, Li X-R, Li W, Song Q, Sun L, Lin F et al (2020) Phosphorylated alpha-synuclein in red blood cells as a potential diagnostic biomarker for multiple system atrophy: a pilot study. Parkinsons Dis 2020:8740419. https:\/\/doi.org\/10.1155\/2020\/8740419","journal-title":"Parkinsons Dis"},{"key":"4561_CR42","doi-asserted-by":"publisher","first-page":"623977","DOI":"10.3389\/fnagi.2021.623977","volume":"13","author":"X-Y Li","year":"2021","unstructured":"Li X-Y, Li W, Li X, Li X-R, Sun L, Yang W, Cai Y, Chen Z et al (2021) Alterations of erythrocytic phosphorylated alpha-synuclein in different subtypes and stages of Parkinson\u2019s disease. Front Aging Neurosci 13:623977. https:\/\/doi.org\/10.3389\/fnagi.2021.623977","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"4561_CR43","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1002\/mds.29620","volume":"39","author":"Y Yang","year":"2024","unstructured":"Yang Y, Stewart T, Zhang C, Wang P, Xu Z, Jin J, Huang Y, Liu Z et al (2024) Erythrocytic \u03b1-synuclein and the gut microbiome: kindling of the gut-brain axis in Parkinson\u2019s disease. Mov Disord 39(1):40\u201352. https:\/\/doi.org\/10.1002\/mds.29620","journal-title":"Mov Disord"},{"key":"4561_CR44","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.peptides.2014.09.018","volume":"62","author":"Y-T Sui","year":"2014","unstructured":"Sui Y-T, Bullock KM, Erickson MA, Zhang J, Banks WA (2014) Alpha synuclein is transported into and out of the brain by the blood-brain barrier. Peptides 62:197\u2013202. https:\/\/doi.org\/10.1016\/j.peptides.2014.09.018","journal-title":"Peptides"},{"issue":"3","key":"4561_CR45","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1093\/jb\/mvac100","volume":"173","author":"R Amagai","year":"2023","unstructured":"Amagai R, Yoshioka S, Otomo R, Nagano H, Hashimoto N, Sakakibara R, Tanaka T, Okado-Matsumoto A (2023) Post-translational modification of lysine residues in erythrocyte \u03b1-synuclein. J Biochem 173(3):177\u2013184. https:\/\/doi.org\/10.1093\/jb\/mvac100","journal-title":"J Biochem"},{"issue":"4","key":"4561_CR46","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.neuron.2019.05.035","volume":"103","author":"S Kim","year":"2019","unstructured":"Kim S, Kwon S-H, Kam T-I, Panicker N, Karuppagounder SS, Lee S, Lee JH, Kim WR et al (2019) Transneuronal propagation of pathologic \u03b1-synuclein from the gut to the brain models Parkinson\u2019s disease. Neuron 103(4):627-641.e7. https:\/\/doi.org\/10.1016\/j.neuron.2019.05.035","journal-title":"Neuron"},{"key":"4561_CR47","doi-asserted-by":"publisher","first-page":"102462","DOI":"10.1016\/j.pneurobio.2023.102462","volume":"226","author":"L Meng","year":"2023","unstructured":"Meng L, Li Y, Liu C, Zhang G, Chen J, Xiong M, Pan L, Zhang X et al (2023) Islet amyloid polypeptide triggers \u03b1-synuclein pathology in Parkinson\u2019s disease. Prog Neurobiol 226:102462. https:\/\/doi.org\/10.1016\/j.pneurobio.2023.102462","journal-title":"Prog Neurobiol"},{"issue":"11","key":"4561_CR48","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1046\/j.1537-2995.2001.41111397.x","volume":"41","author":"D Tamasauskas","year":"2001","unstructured":"Tamasauskas D, Powell V, Schawalder A, Yazdanbakhsh K (2001) Localization of Knops system antigens in the long homologous repeats of complement receptor 1. Transfusion 41(11):1397\u20131404","journal-title":"Transfusion"},{"issue":"1","key":"4561_CR49","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1084\/jem.152.1.20","volume":"152","author":"DT Fearon","year":"1980","unstructured":"Fearon DT (1980) Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte. J Exp Med 152(1):20\u201330","journal-title":"J Exp Med"},{"issue":"4","key":"4561_CR50","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.4049\/jimmunol.130.4.1668","volume":"130","author":"TF Tedder","year":"1983","unstructured":"Tedder TF, Fearon DT, Gartland GL, Cooper MD (1983) Expression of C3b receptors on human be cells and myelomonocytic cells but not natural killer cells. J Immunol 130(4):1668\u20131673","journal-title":"J Immunol"},{"issue":"7","key":"4561_CR51","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/0167-5699(96)80795-X","volume":"17","author":"S Sadallah","year":"1996","unstructured":"Sadallah S, Schifferli JA, Pascual M (1996) Proteolytic cleavage of leukocyte membrane proteins: lessons from CRI. Immunol Today 17(7):345","journal-title":"Immunol Today"},{"issue":"4","key":"4561_CR52","doi-asserted-by":"publisher","first-page":"e124","DOI":"10.1016\/j.jalz.2011.05.2412","volume":"7","author":"C Ant\u00fanez","year":"2011","unstructured":"Ant\u00fanez C, Boada M, L\u00f3pez-Arrieta J, Moreno-Rey C, Hern\u00e1ndez I, Mar\u00edn J, Gay\u00e1n J, Gonz\u00e1lez-P\u00e9rez A et al (2011) Genetic association of complement receptor 1 polymorphism rs3818361 in Alzheimer\u2019s disease. Alzheimers Dement 7(4):e124\u2013e129. https:\/\/doi.org\/10.1016\/j.jalz.2011.05.2412","journal-title":"Alzheimers Dement"},{"issue":"2","key":"4561_CR53","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.jalz.2017.04.015","volume":"14","author":"A Crane","year":"2018","unstructured":"Crane A, Brubaker WD, Johansson JU, Trigunaite A, Ceballos J, Bradt B, Glavis-Bloom C, Wallace TL et al (2018) Peripheral complement interactions with amyloid \u03b2 peptide in Alzheimer\u2019s disease: 2. Relationship to amyloid \u03b2 immunotherapy. Alzheimers Dement 14(2):243\u2013252. https:\/\/doi.org\/10.1016\/j.jalz.2017.04.015","journal-title":"Alzheimers Dement"},{"issue":"6","key":"4561_CR54","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1002\/glia.24355","volume":"71","author":"N Daskoulidou","year":"2023","unstructured":"Daskoulidou N, Shaw B, Torvell M, Watkins L, Cope EL, Carpanini SM, Allen ND, Morgan BP (2023) Complement receptor 1 is expressed on brain cells and in the human brain. Glia 71(6):1522\u20131535. https:\/\/doi.org\/10.1002\/glia.24355","journal-title":"Glia"},{"issue":"21","key":"4561_CR55","doi-asserted-by":"publisher","first-page":"eabq7806","DOI":"10.1126\/sciadv.abq7806","volume":"9","author":"H-Y Chung","year":"2023","unstructured":"Chung H-Y, Wickel J, Hahn N, Mein N, Schwarzbrunn M, Koch P, Ceanga M, Haselmann H et al (2023) Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy. Sci Adv 9(21):eabq7806. https:\/\/doi.org\/10.1126\/sciadv.abq7806","journal-title":"Sci Adv"},{"issue":"11","key":"4561_CR56","doi-asserted-by":"publisher","first-page":"2866","DOI":"10.1038\/s41591-023-02566-3","volume":"29","author":"DK Wilton","year":"2023","unstructured":"Wilton DK, Mastro K, Heller MD, Gergits FW, Willing CR, Fahey JB, Frouin A, Daggett A et al (2023) Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington\u2019s disease. Nat Med 29(11):2866\u20132884. https:\/\/doi.org\/10.1038\/s41591-023-02566-3","journal-title":"Nat Med"},{"issue":"2\u20133","key":"4561_CR57","first-page":"159","volume":"6","author":"DT Fearon","year":"1983","unstructured":"Fearon DT (1983) The human C3b receptor. Springer Semin Immunopathol 6(2\u20133):159\u2013172","journal-title":"Springer Semin Immunopathol"},{"issue":"6","key":"4561_CR58","doi-asserted-by":"publisher","first-page":"3516","DOI":"10.4049\/jimmunol.176.6.3516","volume":"176","author":"D Fairweather","year":"2006","unstructured":"Fairweather D, Frisancho-Kiss S, Njoku DB, Nyland JF, Kaya Z, Yusung SA, Davis SE, Frisancho JA et al (2006) Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart. J Immunol 176(6):3516\u20133524","journal-title":"J Immunol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04561-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04561-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04561-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T10:07:53Z","timestamp":1741082873000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04561-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,29]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["4561"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04561-2","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,29]]},"assertion":[{"value":"16 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animals included in this study were reviewed and approved by the Institutional Animal Care and Use Committee (IACUC, approval No. 20240204B). No human participants were included in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}