{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:08:26Z","timestamp":1793729306034,"version":"4.6.1"},"reference-count":255,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s12035-024-04562-1","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T05:11:08Z","timestamp":1730178668000},"page":"4654-4676","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Mechanisms and Therapeutic Prospects of Microglia-Astrocyte Interactions in Neuropathic Pain Following Spinal Cord Injury"],"prefix":"10.1007","volume":"62","author":[{"given":"Yinuo","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"issue":"1","key":"4562_CR1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5312\/wjo.v6.i1.8","volume":"6","author":"K Nas","year":"2015","unstructured":"Nas K, Yazmalar L, \u015eah V, Ayd\u0131n A, \u00d6ne\u015f K (2015) Rehabilitation of spinal cord injuries. World J Orthopedics 6(1):8\u201316","journal-title":"World J Orthopedics"},{"issue":"1","key":"4562_CR2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12912-024-01797-0","volume":"23","author":"N Galehdar","year":"2024","unstructured":"Galehdar N, Heydari H (2024) Explaining the challenges of Iranian caregivers in provision of home health care to spinal cord injury patients: a qualitative study. BMC Nurs 23(1):142","journal-title":"BMC Nurs"},{"issue":"3","key":"4562_CR3","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s12264-018-0320-9","volume":"35","author":"Q Huang","year":"2019","unstructured":"Huang Q, Duan W, Sivanesan E, Liu S, Yang F, Chen Z et al (2019) Spinal cord stimulation for pain treatment after spinal cord injury. Neurosci Bull 35(3):527\u2013539","journal-title":"Neurosci Bull"},{"issue":"4","key":"4562_CR4","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.apmr.2021.06.022","volume":"103","author":"ER Felix","year":"2022","unstructured":"Felix ER, Cardenas DD, Bryce TN, Charlifue S, Lee TK, MacIntyre B et al (2022) Prevalence and impact of neuropathic and nonneuropathic pain in chronic spinal cord injury. Arch Phys Med Rehabil 103(4):729\u2013737","journal-title":"Arch Phys Med Rehabil"},{"issue":"6","key":"4562_CR5","doi-asserted-by":"crossref","first-page":"438","DOI":"10.5535\/arm.20081","volume":"44","author":"HY Kim","year":"2020","unstructured":"Kim HY, Lee HJ, Kim TL, Kim E, Ham D, Lee J et al (2020) Prevalence and Characteristics of neuropathic pain in patients with spinal cord injury referred to a rehabilitation center. Ann Rehabil Med 44(6):438\u2013449","journal-title":"Ann Rehabil Med"},{"issue":"1","key":"4562_CR6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/physrev.00045.2019","volume":"101","author":"NB Finnerup","year":"2021","unstructured":"Finnerup NB, Kuner R, Jensen TS (2021) Neuropathic pain: from mechanisms to treatment. Physiol Rev 101(1):259\u2013301","journal-title":"Physiol Rev"},{"key":"4562_CR7","doi-asserted-by":"crossref","unstructured":"Jang JY, Lee SH, Kim M, Ryu JS (2014) Characteristics of neuropathic pain in patients with spinal cord injury. Ann Rehab Med. 38(3)","DOI":"10.5535\/arm.2014.38.3.327"},{"issue":"4","key":"4562_CR8","doi-asserted-by":"crossref","first-page":"292","DOI":"10.17712\/nsj.2018.4.20180223","volume":"23","author":"H Majedi","year":"2020","unstructured":"Majedi H, Safdarian M, Hajiaghababaei M, Vaccaro AR, Rahimi-Movaghar V (2020) Characteristics of neuropathic pain in individuals with chronic spinal cord injury. Neurosciences 23(4):292\u2013300","journal-title":"Neurosciences"},{"issue":"8","key":"4562_CR9","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/sc.2012.26","volume":"50","author":"EC Celik","year":"2012","unstructured":"Celik EC, Erhan B, Lakse E (2012) The clinical characteristics of neuropathic pain in patients with spinal cord injury. Spinal cord 50(8):585\u2013589","journal-title":"Spinal cord"},{"issue":"2","key":"4562_CR10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.rehab.2008.12.012","volume":"52","author":"P Calmels","year":"2009","unstructured":"Calmels P, Mick G, Perrouin-Verbe B, Ventura M (2009) Neuropathic pain in spinal cord injury: identification, classification, evaluation. Ann Phys Rehabil Med 52(2):83\u2013102","journal-title":"Ann Phys Rehabil Med"},{"issue":"1","key":"4562_CR11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ejp.905","volume":"21","author":"D Burke","year":"2016","unstructured":"Burke D, Fullen BM, Stokes D, Lennon O (2016) Neuropathic pain prevalence following spinal cord injury: a systematic review and meta-analysis. Eur J Pain 21(1):29\u201344","journal-title":"Eur J Pain"},{"issue":"11","key":"4562_CR12","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s40265-023-01903-7","volume":"83","author":"E Widerstr\u00f6m-Noga","year":"2023","unstructured":"Widerstr\u00f6m-Noga E (2023) Neuropathic pain and spinal cord injury: management, phenotypes, and biomarkers. Drugs 83(11):1001\u20131025","journal-title":"Drugs"},{"issue":"1\u20132","key":"4562_CR13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neurol.2018.09.016","volume":"175","author":"D Bouhassira","year":"2019","unstructured":"Bouhassira D (2019) Neuropathic pain: Definition, assessment and epidemiology. Revue Neurologique 175(1\u20132):16\u201325","journal-title":"Revue Neurologique"},{"issue":"3","key":"4562_CR14","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s13311-018-0633-4","volume":"15","author":"R Shiao","year":"2018","unstructured":"Shiao R, Lee-Kubli CA (2018) Neuropathic pain after spinal cord injury: challenges and research perspectives. Neurotherapeutics 15(3):635\u2013653","journal-title":"Neurotherapeutics"},{"issue":"1","key":"4562_CR15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s40122-015-0033-y","volume":"4","author":"EM Hagen","year":"2015","unstructured":"Hagen EM, Rekand T (2015) Management of neuropathic pain associated with spinal cord injury. Pain Ther 4(1):51\u201365","journal-title":"Pain Ther"},{"issue":"2","key":"4562_CR16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1124\/pr.117.014399","volume":"70","author":"SRA Alles","year":"2018","unstructured":"Alles SRA, Smith PA, Isom LL (2018) Etiology and pharmacology of neuropathic pain. Pharmacol Rev 70(2):315\u2013347","journal-title":"Pharmacol Rev"},{"issue":"8","key":"4562_CR17","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1474-4422(10)70143-5","volume":"9","author":"R Baron","year":"2010","unstructured":"Baron R, Binder A, Wasner G (2010) Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol 9(8):807\u2013819","journal-title":"Lancet Neurol"},{"issue":"3","key":"4562_CR18","first-page":"227","volume":"25","author":"MK Jha","year":"2019","unstructured":"Jha MK, Jo M, Kim JH, Suk K (2019) Microglia-astrocyte crosstalk: an intimate molecular conversation. Neuroscie Rev J Bring Neurobiol Neurol Psych 25(3):227\u2013240","journal-title":"Neuroscie Rev J Bring Neurobiol Neurol Psych"},{"key":"4562_CR19","doi-asserted-by":"crossref","first-page":"105028","DOI":"10.1016\/j.nbd.2020.105028","volume":"144","author":"TI Kam","year":"2020","unstructured":"Kam TI, Hinkle JT, Dawson TM, Dawson VL (2020) Microglia and astrocyte dysfunction in Parkinson\u2019s disease. Neurobiol Dis 144:105028","journal-title":"Neurobiol Dis"},{"issue":"3","key":"4562_CR20","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.tins.2020.01.003","volume":"43","author":"ID Vainchtein","year":"2020","unstructured":"Vainchtein ID, Molofsky AV (2020) Astrocytes and microglia: in sickness and in health. Trends Neurosci 43(3):144\u2013154","journal-title":"Trends Neurosci"},{"issue":"6312","key":"4562_CR21","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.aaf8924","volume":"354","author":"RR Ji","year":"2016","unstructured":"Ji RR, Chamessian A, Zhang YQ (2016) Pain regulation by non-neuronal cells and inflammation. Science (New York, NY) 354(6312):572\u2013577","journal-title":"Science (New York, NY)"},{"issue":"2","key":"4562_CR22","doi-asserted-by":"crossref","first-page":"e2868","DOI":"10.1002\/brb3.2868","volume":"13","author":"T Zhang","year":"2023","unstructured":"Zhang T, Zhang M, Cui S, Liang W, Jia Z, Guo F et al (2023) The core of maintaining neuropathic pain: crosstalk between glial cells and neurons (neural cell crosstalk at spinal cord). Brain Behav 13(2):e2868","journal-title":"Brain Behav"},{"key":"4562_CR23","doi-asserted-by":"crossref","unstructured":"Liu L-r, Liu J-c, Bao J-s, Bai Q-q, Wang G-q (2020S) Interaction of microglia and astrocytes in the neurovascular unit. Front Immunol 11","DOI":"10.3389\/fimmu.2020.01024"},{"issue":"1","key":"4562_CR24","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev-immunol-032713-120240","volume":"32","author":"D Nayak","year":"2014","unstructured":"Nayak D, Roth TL, McGavern DB (2014) Microglia development and function. Annu Rev Immunol 32(1):367\u2013402","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"4562_CR25","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","volume":"35","author":"M Colonna","year":"2017","unstructured":"Colonna M, Butovsky O (2017) Microglia function in the central nervous system during health and neurodegeneration. Annu Rev Immunol 35(1):441\u2013468","journal-title":"Annu Rev Immunol"},{"key":"4562_CR26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-1-4939-9658-2_2","volume":"2034","author":"JC Savage","year":"2019","unstructured":"Savage JC, Carrier M, Tremblay M (2019) Morphology of microglia across contexts of health and disease. Meth Mol Biol (Clifton, NJ) 2034:13\u201326","journal-title":"Meth Mol Biol (Clifton, NJ)"},{"issue":"5\u20136","key":"4562_CR27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.lfs.2011.05.011","volume":"89","author":"W Liu","year":"2011","unstructured":"Liu W, Tang Y, Feng J (2011) Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system. Life Sci 89(5\u20136):141\u2013146","journal-title":"Life Sci"},{"issue":"2","key":"4562_CR28","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.cell.2019.08.053","volume":"179","author":"M Prinz","year":"2019","unstructured":"Prinz M, Jung S, Priller J (2019) Microglia biology: one century of evolving concepts. Cell 179(2):292\u2013311","journal-title":"Cell"},{"issue":"2","key":"4562_CR29","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.201709069","volume":"217","author":"DV Hansen","year":"2018","unstructured":"Hansen DV, Hanson JE, Sheng M (2018) Microglia in Alzheimer\u2019s disease. J Cell Biol 217(2):459\u2013472","journal-title":"J Cell Biol"},{"key":"4562_CR30","first-page":"71","volume":"4","author":"HS Domingues","year":"2016","unstructured":"Domingues HS, Portugal CC, Socodato R, Relvas JB (2016) Oligodendrocyte, astrocyte, and microglia crosstalk in myelin development, damage, and repair. Front Cell Dev Biol 4:71","journal-title":"Front Cell Dev Biol"},{"issue":"6","key":"4562_CR31","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","volume":"46","author":"SA Liddelow","year":"2017","unstructured":"Liddelow SA, Barres BA (2017) Reactive astrocytes: production, function, and therapeutic potential. Immunity 46(6):957\u2013967","journal-title":"Immunity"},{"key":"4562_CR32","doi-asserted-by":"crossref","unstructured":"Lukacova N, Kisucka A, Kiss Bimbova K, Bacova M, Ileninova M, Kuruc T et al. (2021) Glial-neuronal interactions in pathogenesis and treatment of spinal cord injury. Int J Mol Sci 22(24)","DOI":"10.3390\/ijms222413577"},{"issue":"3\u20134","key":"4562_CR33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/09727531211046367","volume":"28","author":"GS Miranpuri","year":"2021","unstructured":"Miranpuri GS, Bali P, Nguyen J, Kim JJ, Modgil S, Mehra P et al (2021) Role of microglia and astrocytes in spinal cord injury induced neuropathic pain. Ann Neurosci 28(3\u20134):219\u2013228","journal-title":"Ann Neurosci"},{"key":"4562_CR34","doi-asserted-by":"crossref","unstructured":"Brockie S, Hong J, Fehlings MG (2021) The role of microglia in modulating neuroinflammation after spinal cord injury. Int J Mol Sci 22(18)","DOI":"10.3390\/ijms22189706"},{"issue":"16","key":"4562_CR35","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1523\/JNEUROSCI.0003-06.2006","volume":"26","author":"BC Hains","year":"2006","unstructured":"Hains BC, Waxman SG (2006) Activated microglia contribute to the maintenance of chronic pain after spinal cord injury. J Neurosci 26(16):4308\u20134317","journal-title":"J Neurosci"},{"issue":"6","key":"4562_CR36","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/cns.13123","volume":"25","author":"B Zhou","year":"2019","unstructured":"Zhou B, Zuo YX, Jiang RT (2019) Astrocyte morphology: diversity, plasticity, and role in neurological diseases. CNS Neurosci Ther 25(6):665\u2013673","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"4562_CR37","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41593-018-0286-y","volume":"22","author":"C Garc\u00eda-C\u00e1ceres","year":"2019","unstructured":"Garc\u00eda-C\u00e1ceres C, Balland E, Prevot V, Luquet S, Woods SC, Koch M et al (2019) Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism. Nat Neurosci 22(1):7\u201314","journal-title":"Nat Neurosci"},{"issue":"9","key":"4562_CR38","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.it.2020.07.004","volume":"41","author":"MV Sofroniew","year":"2020","unstructured":"Sofroniew MV (2020) Astrocyte reactivity: subtypes, states, and functions in CNS innate immunity. Trends Immunol 41(9):758\u2013770","journal-title":"Trends Immunol"},{"key":"4562_CR39","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.pneurobio.2015.04.003","volume":"130","author":"D Rossi","year":"2015","unstructured":"Rossi D (2015) Astrocyte physiopathology: at the crossroads of intercellular networking, inflammation and cell death. Prog Neurobiol 130:86\u2013120","journal-title":"Prog Neurobiol"},{"issue":"4","key":"4562_CR40","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.nurt.2010.05.016","volume":"7","author":"Y-J Gao","year":"2010","unstructured":"Gao Y-J, Ji R-R (2010) Targeting astrocyte signaling for chronic pain. Neurotherapeutics 7(4):482\u2013493","journal-title":"Neurotherapeutics"},{"issue":"7","key":"4562_CR41","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nn.4043","volume":"18","author":"BS Khakh","year":"2015","unstructured":"Khakh BS, Sofroniew MV (2015) Diversity of astrocyte functions and phenotypes in neural circuits. Nat Neurosci 18(7):942\u2013952","journal-title":"Nat Neurosci"},{"key":"4562_CR42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-1-61779-452-0_3","volume":"814","author":"NA Oberheim","year":"2012","unstructured":"Oberheim NA, Goldman SA, Nedergaard M (2012) Heterogeneity of astrocytic form and function. Methods Mol Biol 814:23\u201345","journal-title":"Methods Mol Biol"},{"issue":"4","key":"4562_CR43","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cmet.2023.03.006","volume":"35","author":"P Hasel","year":"2023","unstructured":"Hasel P, Aisenberg WH, Bennett FC, Liddelow SA (2023) Molecular and metabolic heterogeneity of astrocytes and microglia. Cell Metab 35(4):555\u2013570","journal-title":"Cell Metab"},{"issue":"1\u20133","key":"4562_CR44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.pain.2009.09.030","volume":"147","author":"SM Carlton","year":"2009","unstructured":"Carlton SM, Du J, Tan HY, Nesic O, Hargett GL, Bopp AC et al (2009) Peripheral and central sensitization in remote spinal cord regions contribute to central neuropathic pain after spinal cord injury. Pain 147(1\u20133):265\u2013276","journal-title":"Pain"},{"key":"4562_CR45","doi-asserted-by":"crossref","unstructured":"Fan Y-Y, Huo J (2021) A1\/A2 astrocytes in central nervous system injuries and diseases: angels or devils? Neurochemistry International. 148","DOI":"10.1016\/j.neuint.2021.105080"},{"key":"4562_CR46","doi-asserted-by":"crossref","first-page":"573256","DOI":"10.3389\/fimmu.2020.573256","volume":"11","author":"M Linnerbauer","year":"2020","unstructured":"Linnerbauer M, Rothhammer V (2020) Protective functions of reactive astrocytes following central nervous system insult. Front Immunol 11:573256","journal-title":"Front Immunol"},{"issue":"1","key":"4562_CR47","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","volume":"119","author":"MV Sofroniew","year":"2010","unstructured":"Sofroniew MV, Vinters HV (2010) Astrocytes: biology and pathology. Acta Neuropathol 119(1):7\u201335","journal-title":"Acta Neuropathol"},{"issue":"6","key":"4562_CR48","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/glia.24343","volume":"71","author":"Y Liu","year":"2023","unstructured":"Liu Y, Shen X, Zhang Y, Zheng X, Cepeda C, Wang Y et al (2023) Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells. Glia 71(6):1383\u20131401","journal-title":"Glia"},{"issue":"3","key":"4562_CR49","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.neuroscience.2009.03.055","volume":"161","author":"YS Gwak","year":"2009","unstructured":"Gwak YS, Hulsebosch CE (2009) Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat. Neuroscience 161(3):895\u2013903","journal-title":"Neuroscience"},{"issue":"3","key":"4562_CR50","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","volume":"24","author":"C Escartin","year":"2021","unstructured":"Escartin C, Galea E, Lakatos A, O\u2019Callaghan JP, Petzold GC, Serrano-Pozo A et al (2021) Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci 24(3):312\u2013325","journal-title":"Nat Neurosci"},{"issue":"7638","key":"4562_CR51","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","volume":"541","author":"SA Liddelow","year":"2017","unstructured":"Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L et al (2017) Neurotoxic reactive astrocytes are induced by activated microglia. Nature 541(7638):481\u2013487","journal-title":"Nature"},{"issue":"1","key":"4562_CR52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.5853\/jos.2019.02236","volume":"22","author":"C Tschoe","year":"2020","unstructured":"Tschoe C, Bushnell CD, Duncan PW, Alexander-Miller MA, Wolfe SQ (2020) Neuroinflammation after intracerebral hemorrhage and potential therapeutic targets. J Stroke 22(1):29\u201346","journal-title":"J Stroke"},{"key":"4562_CR53","doi-asserted-by":"crossref","unstructured":"Sommer C, Leinders M, \u00dc\u00e7eyler N (2018) Inflammation in the pathophysiology of neuropathic pain. 159(3):595-602","DOI":"10.1097\/j.pain.0000000000001122"},{"key":"4562_CR54","doi-asserted-by":"crossref","unstructured":"Gallyas F, Ji X-T, Qian N-S, Zhang T, Li J-M, Li X-K et al. (2013) Spinal astrocytic activation contributes to mechanical allodynia in a rat chemotherapy-induced neuropathic pain model. PloS one 8(4)","DOI":"10.1371\/journal.pone.0060733"},{"issue":"1","key":"4562_CR55","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","volume":"9","author":"HS Kwon","year":"2020","unstructured":"Kwon HS, Koh SH (2020) Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl Neurodegener 9(1):42","journal-title":"Transl Neurodegener"},{"key":"4562_CR56","doi-asserted-by":"crossref","unstructured":"Ellis A, Bennett DLH (2013) Neuroinflammation and the generation of neuropathic pain. BJA: British J Anaesthesia. 111(1):26\u201337","DOI":"10.1093\/bja\/aet128"},{"issue":"2","key":"4562_CR57","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.expneurol.2011.10.010","volume":"234","author":"YS Gwak","year":"2012","unstructured":"Gwak YS, Kang J, Unabia GC, Hulsebosch CE (2012) Spatial and temporal activation of spinal glial cells: role of gliopathy in central neuropathic pain following spinal cord injury in rats. Exp Neurol 234(2):362\u2013372","journal-title":"Exp Neurol"},{"issue":"4","key":"4562_CR58","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/glia.23570","volume":"67","author":"H Tozaki-Saitoh","year":"2019","unstructured":"Tozaki-Saitoh H, Masuda J, Kawada R, Kojima C, Yoneda S, Masuda T et al (2019) Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development. Glia 67(4):729\u2013740","journal-title":"Glia"},{"issue":"12","key":"4562_CR59","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1002\/glia.24451","volume":"71","author":"JC Perez","year":"2023","unstructured":"Perez JC, Poulen G, Cardoso M, Boukhaddaoui H, Gazard CM, Courtand G et al (2023) CSF1R inhibition at chronic stage after spinal cord injury modulates microglia proliferation. Glia 71(12):2782\u20132798","journal-title":"Glia"},{"issue":"1","key":"4562_CR60","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s12974-020-01973-4","volume":"17","author":"H Fan","year":"2020","unstructured":"Fan H, Tang H-B, Chen Z, Wang H-Q, Zhang L, Jiang Y et al (2020) Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages\/microglia polarization and affords neuroprotection after spinal cord injury. J Neuroinflammation 17(1):295","journal-title":"J Neuroinflammation"},{"issue":"4","key":"4562_CR61","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/bja\/aex006","volume":"118","author":"H Zhao","year":"2017","unstructured":"Zhao H, Alam A, Chen Q, M AE, Pal A, Eguchi S et al (2017) The role of microglia in the pathobiology of neuropathic pain development: what do we know? Br J Anaesth. 118(4):504\u201316","journal-title":"Br J Anaesth."},{"key":"4562_CR62","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3389\/fncel.2019.00525","volume":"13","author":"K Honjoh","year":"2019","unstructured":"Honjoh K, Nakajima H, Hirai T, Watanabe S, Matsumine A (2019) Relationship of inflammatory cytokines from M1-type microglia\/macrophages at the injured site and lumbar enlargement with neuropathic pain after spinal cord injury in the CCL21 Knockout (plt) mouse. Front Cell Neurosci 13:525","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"4562_CR63","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s12035-020-02102-1","volume":"58","author":"S Tang","year":"2021","unstructured":"Tang S, Jing H, Song F, Huang H, Li W, Xie G et al (2021) MicroRNAs in the spinal microglia serve critical roles in neuropathic pain. Mol Neurobiol 58(1):132\u2013142","journal-title":"Mol Neurobiol"},{"issue":"6","key":"4562_CR64","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/jnr.23816","volume":"95","author":"M Tsuda","year":"2017","unstructured":"Tsuda M (2017) P2 receptors, microglial cytokines and chemokines, and neuropathic pain. J Neurosci Res 95(6):1319\u20131329","journal-title":"J Neurosci Res"},{"issue":"6","key":"4562_CR65","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.neuron.2018.11.009","volume":"100","author":"G Chen","year":"2018","unstructured":"Chen G, Zhang YQ, Qadri YJ, Serhan CN, Ji RR (2018) Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain. Neuron 100(6):1292\u20131311","journal-title":"Neuron"},{"issue":"6950","key":"4562_CR66","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nature01786","volume":"424","author":"M Tsuda","year":"2003","unstructured":"Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW et al (2003) P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424(6950):778\u2013783","journal-title":"Nature"},{"issue":"8","key":"4562_CR67","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/nn.3155","volume":"15","author":"S Beggs","year":"2012","unstructured":"Beggs S, Trang T, Salter MW (2012) P2X4R+ microglia drive neuropathic pain. Nat Neurosci 15(8):1068\u20131073","journal-title":"Nat Neurosci"},{"issue":"3","key":"4562_CR68","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nrn.2018.2","volume":"19","author":"K Inoue","year":"2018","unstructured":"Inoue K, Tsuda M (2018) Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential. Nat Rev Neurosci 19(3):138\u2013152","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"4562_CR69","doi-asserted-by":"crossref","first-page":"e864","DOI":"10.1097\/PR9.0000000000000864","volume":"6","author":"K Kohno","year":"2021","unstructured":"Kohno K, Tsuda M (2021) Role of microglia and P2X4 receptors in chronic pain. Pain Rep 6(1):e864","journal-title":"Pain Rep"},{"issue":"9","key":"4562_CR70","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1097\/j.pain.0000000000000982","volume":"158","author":"S Echeverry","year":"2017","unstructured":"Echeverry S, Shi XQ, Yang M, Huang H, Wu Y, Lorenzo LE et al (2017) Spinal microglia are required for long-term maintenance of neuropathic pain. Pain 158(9):1792\u20131801","journal-title":"Pain"},{"issue":"7","key":"4562_CR71","doi-asserted-by":"crossref","first-page":"e3001337","DOI":"10.1371\/journal.pbio.3001337","volume":"19","author":"L Huang","year":"2021","unstructured":"Huang L, Jin J, Chen K, You S, Zhang H, Sideris A et al (2021) BDNF produced by cerebral microglia promotes cortical plasticity and pain hypersensitivity after peripheral nerve injury. PLoS Biol 19(7):e3001337","journal-title":"PLoS Biol"},{"key":"4562_CR72","first-page":"174480692412581","volume":"20","author":"M Zhou","year":"2024","unstructured":"Zhou M, Pang F, Liao D, Yang Y, Wang Y, Yang Z et al (2024) Electroacupuncture improves allodynia and central sensitization via modulation of microglial activation associated P2X4R and inflammation in a rat model of migraine. Mol Pain 20:17448069241258112","journal-title":"Mol Pain"},{"issue":"10","key":"4562_CR73","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1007\/s11064-023-03969-x","volume":"48","author":"WM Zhou","year":"2023","unstructured":"Zhou WM, Lei ZY, Shi YQ, Gong CY, Kai Z, Wei N et al (2023) Intrathecal injection of botulinum toxin type A has an analgesic effect in male rats CCI model by inhibiting the activation of spinal P2X4R. Neurochem Res 48(10):3099\u20133112","journal-title":"Neurochem Res"},{"issue":"2","key":"4562_CR74","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.expneurol.2008.05.025","volume":"213","author":"ED Crown","year":"2008","unstructured":"Crown ED, Gwak YS, Ye Z, Johnson KM, Hulsebosch CE (2008) Activation of p38 MAP kinase is involved in central neuropathic pain following spinal cord injury. Exp Neurol 213(2):257\u2013267","journal-title":"Exp Neurol"},{"issue":"1","key":"4562_CR75","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12974-020-01754-z","volume":"17","author":"L Wang","year":"2020","unstructured":"Wang L, Yin C, Liu T, Abdul M, Zhou Y, Cao J-L et al (2020) Pellino1 regulates neuropathic pain as well as microglial activation through the regulation of MAPK\/NF-\u03baB signaling in the spinal cord. J Neuroinflammation 17(1):83","journal-title":"J Neuroinflammation"},{"issue":"1\u20132","key":"4562_CR76","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.pharmthera.2005.07.001","volume":"109","author":"K Inoue","year":"2006","unstructured":"Inoue K (2006) The function of microglia through purinergic receptors: neuropathic pain and cytokine release. Pharmacol Ther 109(1\u20132):210\u2013226","journal-title":"Pharmacol Ther"},{"issue":"2","key":"4562_CR77","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.expneurol.2012.05.014","volume":"236","author":"DC Choi","year":"2012","unstructured":"Choi DC, Lee JY, Lim EJ, Baik HH, Oh TH, Yune TY (2012) Inhibition of ROS-induced p38MAPK and ERK activation in microglia by acupuncture relieves neuropathic pain after spinal cord injury in rats. Exp Neurol 236(2):268\u2013282","journal-title":"Exp Neurol"},{"key":"4562_CR78","first-page":"33","volume":"3","author":"RR Ji","year":"2007","unstructured":"Ji RR, Suter MR (2007) p38 MAPK, microglial signaling, and neuropathic pain. Mol Pain 3:33","journal-title":"Mol Pain"},{"key":"4562_CR79","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbi.2015.10.006","volume":"55","author":"S Taves","year":"2016","unstructured":"Taves S, Berta T, Liu DL, Gan S, Chen G, Kim YH et al (2016) Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: sex-dependent microglial signaling in the spinal cord. Brain Behav Immun 55:70\u201381","journal-title":"Brain Behav Immun"},{"issue":"10","key":"4562_CR80","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1177\/0022034516653604","volume":"95","author":"T Berta","year":"2016","unstructured":"Berta T, Qadri YJ, Chen G, Ji RR (2016) Microglial signaling in chronic pain with a special focus on caspase 6, p38 MAP kinase, and sex dependence. J Dent Res 95(10):1124\u20131131","journal-title":"J Dent Res"},{"key":"4562_CR81","doi-asserted-by":"crossref","unstructured":"Biber K, Boddeke E (2014) Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain. Front Cell Neurosci 8","DOI":"10.3389\/fncel.2014.00210"},{"issue":"3","key":"4562_CR82","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/j.1471-4159.2006.03746.x","volume":"97","author":"J Zhang","year":"2006","unstructured":"Zhang J, De Koninck Y (2006) Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury. J Neurochem 97(3):772\u2013783","journal-title":"J Neurochem"},{"issue":"3","key":"4562_CR83","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ejpain.2008.04.017","volume":"13","author":"MA Thacker","year":"2009","unstructured":"Thacker MA, Clark AK, Bishop T, Grist J, Yip PK, Moon LD et al (2009) CCL2 is a key mediator of microglia activation in neuropathic pain states. Eur J Pain 13(3):263\u2013272","journal-title":"Eur J Pain"},{"key":"4562_CR84","doi-asserted-by":"crossref","unstructured":"Li Q, Yang Z, Wang K, Chen Z, Shen H (2023) Suppression of microglial Ccl2 reduces neuropathic pain associated with chronic spinal compression. Frontiers in Immunology 14","DOI":"10.3389\/fimmu.2023.1191188"},{"issue":"45","key":"4562_CR85","doi-asserted-by":"crossref","first-page":"12396","DOI":"10.1523\/JNEUROSCI.3016-07.2007","volume":"27","author":"J Zhang","year":"2007","unstructured":"Zhang J, Shi XQ, Echeverry S, Mogil JS, De Koninck Y, Rivest S (2007) Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J Neurosci 27(45):12396\u201312406","journal-title":"J Neurosci"},{"key":"4562_CR86","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneuroim.2016.04.017","volume":"297","author":"A Piotrowska","year":"2016","unstructured":"Piotrowska A, Kwiatkowski K, Rojewska E, Slusarczyk J, Makuch W, Basta-Kaim A et al (2016) Direct and indirect pharmacological modulation of CCL2\/CCR2 pathway results in attenuation of neuropathic pain \u2014 in vivo and in vitro evidence. J Neuroimmunol 297:9\u201319","journal-title":"J Neuroimmunol"},{"issue":"1","key":"4562_CR87","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/jdi.12379","volume":"7","author":"M Tsuda","year":"2016","unstructured":"Tsuda M (2016) Microglia in the spinal cord and neuropathic pain. J Diabetes Investig 7(1):17\u201326","journal-title":"J Diabetes Investig"},{"issue":"8","key":"4562_CR88","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nn.4053","volume":"18","author":"RE Sorge","year":"2015","unstructured":"Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK et al (2015) Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci 18(8):1081\u20131083","journal-title":"Nat Neurosci"},{"key":"4562_CR89","doi-asserted-by":"crossref","first-page":"114570","DOI":"10.1016\/j.expneurol.2023.114570","volume":"370","author":"C Sun","year":"2023","unstructured":"Sun C, Deng J, Ma Y, Meng F, Cui X, Li M et al (2023) The dual role of microglia in neuropathic pain after spinal cord injury: detrimental and protective effects. Exp Neurol 370:114570","journal-title":"Exp Neurol"},{"issue":"11","key":"4562_CR90","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.tins.2003.09.008","volume":"26","author":"MV Bennett","year":"2003","unstructured":"Bennett MV, Contreras JE, Bukauskas FF, S\u00e1ez JC (2003) New roles for astrocytes: gap junction hemichannels have something to communicate. Trends Neurosci 26(11):610\u2013617","journal-title":"Trends Neurosci"},{"issue":"1","key":"4562_CR91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.20567","volume":"489","author":"IH Lee","year":"2005","unstructured":"Lee IH, Lindqvist E, Kiehn O, Widenfalk J, Olson L (2005) Glial and neuronal connexin expression patterns in the rat spinal cord during development and following injury. J Comp Neurol 489(1):1\u201310","journal-title":"J Comp Neurol"},{"key":"4562_CR92","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuropharm.2016.08.027","volume":"111","author":"SR Choi","year":"2016","unstructured":"Choi SR, Roh DH, Yoon SY, Kwon SG, Choi HS, Han HJ et al (2016) Astrocyte sigma-1 receptors modulate connexin 43 expression leading to the induction of below-level mechanical allodynia in spinal cord injured mice. Neuropharmacology 111:34\u201346","journal-title":"Neuropharmacology"},{"issue":"Pt 8","key":"4562_CR93","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1093\/brain\/awu140","volume":"137","author":"G Chen","year":"2014","unstructured":"Chen G, Park CK, Xie RG, Berta T, Nedergaard M, Ji RR (2014) Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. Brain 137(Pt 8):2193\u20132209","journal-title":"Brain"},{"issue":"3","key":"4562_CR94","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s10565-021-09631-y","volume":"39","author":"GZ Li","year":"2023","unstructured":"Li GZ, Hu YH, Lu YN, Yang QY, Fu D, Chen F et al (2023) CaMKII and Ca(V)3.2 T-type calcium channel mediate connexin-43-dependent inflammation by activating astrocytes in vincristine-induced neuropathic pain. Cell Biol Toxicol 39(3):679\u2013702","journal-title":"Cell Biol Toxicol"},{"issue":"11","key":"4562_CR95","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1002\/glia.22384","volume":"60","author":"MJ Chen","year":"2012","unstructured":"Chen MJ, Kress B, Han X, Moll K, Peng W, Ji RR et al (2012) Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. Glia 60(11):1660\u20131670","journal-title":"Glia"},{"issue":"3","key":"4562_CR96","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1089\/neu.2016.4625","volume":"34","author":"Y Mao","year":"2017","unstructured":"Mao Y, Tonkin RS, Nguyen T, O\u2019Carroll SJ, Nicholson LF, Green CR et al (2017) Systemic administration of connexin43 mimetic peptide improves functional recovery after traumatic spinal cord injury in adult rats. J Neurotrauma 34(3):707\u2013719","journal-title":"J Neurotrauma"},{"key":"4562_CR97","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neulet.2014.03.004","volume":"566","author":"Q Xu","year":"2014","unstructured":"Xu Q, Cheong YK, He SQ, Tiwari V, Liu J, Wang Y et al (2014) Suppression of spinal connexin 43 expression attenuates mechanical hypersensitivity in rats after an L5 spinal nerve injury. Neurosci Lett 566:194\u2013199","journal-title":"Neurosci Lett"},{"key":"4562_CR98","doi-asserted-by":"crossref","unstructured":"Su Y, Verkhratsky A, Yi C (2024) Targeting connexins: possible game changer in managing neuropathic pain? Trends Mol Med","DOI":"10.1016\/j.molmed.2024.03.009"},{"issue":"5","key":"4562_CR99","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1007\/s11064-015-1815-7","volume":"41","author":"LH Hang","year":"2016","unstructured":"Hang LH, Li SN, Luo H, Shu WW, Mao ZM, Chen YF et al (2016) Connexin 43 mediates CXCL12 production from spinal dorsal horn to maintain bone cancer pain in rats. Neurochem Res 41(5):1200\u20131208","journal-title":"Neurochem Res"},{"issue":"3","key":"4562_CR100","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.pneurobio.2011.01.005","volume":"93","author":"J Middeldorp","year":"2011","unstructured":"Middeldorp J, Hol EM (2011) GFAP in health and disease. Prog Neurobiol 93(3):421\u2013443","journal-title":"Prog Neurobiol"},{"key":"4562_CR101","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ceb.2015.02.004","volume":"32","author":"EM Hol","year":"2015","unstructured":"Hol EM, Pekny M (2015) Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system. Curr Opin Cell Biol 32:121\u2013130","journal-title":"Curr Opin Cell Biol"},{"issue":"4","key":"4562_CR102","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1111\/j.1471-4159.2005.03462.x","volume":"95","author":"O Nesic","year":"2005","unstructured":"Nesic O, Lee J, Johnson KM, Ye Z, Xu GY, Unabia GC et al (2005) Transcriptional profiling of spinal cord injury-induced central neuropathic pain. J Neurochem 95(4):998\u20131014","journal-title":"J Neurochem"},{"issue":"5","key":"4562_CR103","first-page":"547","volume":"43","author":"Z Baisong","year":"2018","unstructured":"Baisong Z, Yongying P, Haiping X, Xingrong S (2018) Kindlin-1 Regulates astrocyte activation and pain sensitivity in rats with neuropathic pain. Reg Anesth Pain Med 43(5):547","journal-title":"Reg Anesth Pain Med"},{"issue":"1","key":"4562_CR104","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejphar.2013.01.072","volume":"716","author":"J Mika","year":"2013","unstructured":"Mika J, Zychowska M, Popiolek-Barczyk K, Rojewska E, Przewlocka B (2013) Importance of glial activation in neuropathic pain. Eur J Pharmacol 716(1):106\u2013119","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"4562_CR105","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/ana.20855","volume":"59","author":"XM Peng","year":"2006","unstructured":"Peng XM, Zhou ZG, Glorioso JC, Fink DJ, Mata M (2006) Tumor necrosis factor-alpha contributes to below-level neuropathic pain after spinal cord injury. Ann Neurol 59(5):843\u2013851","journal-title":"Ann Neurol"},{"issue":"3","key":"4562_CR106","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.pain.2005.11.011","volume":"120","author":"G Wolf","year":"2006","unstructured":"Wolf G, Gabay E, Tal M, Yirmiya R, Shavit Y (2006) Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice. Pain 120(3):315\u2013324","journal-title":"Pain"},{"key":"4562_CR107","doi-asserted-by":"crossref","unstructured":"Akimoto N, Honda K, Uta D, Beppu K, Ushijima Y, Matsuzaki Y et al. (2013) CCL-1 in the spinal cord contributes to neuropathic pain induced by nerve injury. Cell Death & Disease 4(6):e679-e","DOI":"10.1038\/cddis.2013.198"},{"issue":"2","key":"4562_CR108","doi-asserted-by":"crossref","first-page":"e00306","DOI":"10.1016\/j.neurot.2023.e00306","volume":"21","author":"Y Song","year":"2024","unstructured":"Song Y, Xue T, Guo S, Yu Z, Yun C, Zhao J et al (2024) Inhibition of aquaporin-4 and its subcellular localization attenuates below-level central neuropathic pain by regulating astrocyte activation in a rat spinal cord injury model. Neurotherapeutics 21(2):e00306","journal-title":"Neurotherapeutics"},{"issue":"14","key":"4562_CR109","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1523\/JNEUROSCI.3353-16.2017","volume":"37","author":"JJ Matyas","year":"2017","unstructured":"Matyas JJ, O\u2019Driscoll CM, Yu L, Coll-Miro M, Daugherty S, Renn CL et al (2017) Truncated TrkB.T1-mediated astrocyte dysfunction contributes to impaired motor function and neuropathic pain after spinal cord injury. J Neurosci. 37(14):3956\u201371","journal-title":"J Neurosci."},{"issue":"9","key":"4562_CR110","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00018-022-04510-z","volume":"79","author":"N Nakajima","year":"2022","unstructured":"Nakajima N, Ohnishi Y, Yamamoto M, Setoyama D, Imai H, Takenaka T et al (2022) Excess intracellular ATP causes neuropathic pain following spinal cord injury. Cell Mol Life Sci 79(9):483","journal-title":"Cell Mol Life Sci"},{"issue":"12","key":"4562_CR111","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.4103\/1673-5374.221144","volume":"12","author":"FM Nathan","year":"2017","unstructured":"Nathan FM, Li S (2017) Environmental cues determine the fate of astrocytes after spinal cord injury. Neural Regen Res 12(12):1964\u20131970","journal-title":"Neural Regen Res"},{"issue":"3","key":"4562_CR112","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nm1723","volume":"14","author":"Y Kawasaki","year":"2008","unstructured":"Kawasaki Y, Xu ZZ, Wang X, Park JY, Zhuang ZY, Tan PH et al (2008) Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. Nat Med 14(3):331\u2013336","journal-title":"Nat Med"},{"issue":"1\u20132","key":"4562_CR113","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pain.2004.12.022","volume":"114","author":"ZY Zhuang","year":"2005","unstructured":"Zhuang ZY, Gerner P, Woolf CJ, Ji RR (2005) ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain 114(1\u20132):149\u2013159","journal-title":"Pain"},{"issue":"20","key":"4562_CR114","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1523\/JNEUROSCI.3338-07.2008","volume":"28","author":"Y Kawasaki","year":"2008","unstructured":"Kawasaki Y, Zhang L, Cheng JK, Ji RR (2008) Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J Neurosci 28(20):5189\u20135194","journal-title":"J Neurosci"},{"issue":"12","key":"4562_CR115","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.tins.2003.09.017","volume":"26","author":"RR Ji","year":"2003","unstructured":"Ji RR, Kohno T, Moore KA, Woolf CJ (2003) Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci 26(12):696\u2013705","journal-title":"Trends Neurosci"},{"issue":"13","key":"4562_CR116","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1523\/JNEUROSCI.3623-08.2009","volume":"29","author":"YJ Gao","year":"2009","unstructured":"Gao YJ, Zhang L, Samad OA, Suter MR, Yasuhiko K, Xu ZZ et al (2009) JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. J Neurosci 29(13):4096\u20134108","journal-title":"J Neurosci"},{"issue":"5472","key":"4562_CR117","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","volume":"288","author":"CJ Woolf","year":"2000","unstructured":"Woolf CJ, Salter MW (2000) Neuronal plasticity: increasing the gain in pain. Science 288(5472):1765\u20131769","journal-title":"Science"},{"key":"4562_CR118","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fncel.2018.00040","volume":"12","author":"P Dubov\u00fd","year":"2018","unstructured":"Dubov\u00fd P, Klus\u00e1kov\u00e1 I, Hradilov\u00e1-Sv\u00ed\u017eensk\u00e1 I, Joukal M, Boadas-Vaello P (2018) Activation of astrocytes and microglial cells and CCL2\/CCR2 upregulation in the dorsolateral and ventrolateral nuclei of periaqueductal gray and rostral ventromedial medulla following different types of sciatic nerve injury. Front Cell Neurosci 12:40","journal-title":"Front Cell Neurosci"},{"key":"4562_CR119","first-page":"f7656","volume":"348","author":"SP Cohen","year":"2014","unstructured":"Cohen SP, Mao J (2014) Neuropathic pain: mechanisms and their clinical implications. BMJ (Clinical research ed) 348:f7656","journal-title":"BMJ (Clinical research ed)"},{"issue":"6","key":"4562_CR120","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/glia.22647","volume":"62","author":"DM Norden","year":"2014","unstructured":"Norden DM, Fenn AM, Dugan A, Godbout JP (2014) TGF\u03b2 produced by IL-10 redirected astrocytes attenuates microglial activation. Glia 62(6):881\u2013895","journal-title":"Glia"},{"issue":"7","key":"4562_CR121","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.tips.2009.04.002","volume":"30","author":"RR Ji","year":"2009","unstructured":"Ji RR, Xu ZZ, Wang X, Lo EH (2009) Matrix metalloprotease regulation of neuropathic pain. Trends Pharmacol Sci 30(7):336\u2013340","journal-title":"Trends Pharmacol Sci"},{"issue":"3","key":"4562_CR122","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1172\/JCI72230","volume":"124","author":"T Berta","year":"2014","unstructured":"Berta T, Park CK, Xu ZZ, Xie RG, Liu T, L\u00fc N et al (2014) Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-\u03b1 secretion. J Clin Invest 124(3):1173\u20131186","journal-title":"J Clin Invest"},{"issue":"3","key":"4562_CR123","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/s13311-020-00905-7","volume":"17","author":"CR Donnelly","year":"2020","unstructured":"Donnelly CR, Andriessen AS, Chen G, Wang K, Jiang C, Maixner W et al (2020) Central nervous system targets: glial cell mechanisms in chronic pain. Neurotherapeutics 17(3):846\u2013860","journal-title":"Neurotherapeutics"},{"key":"4562_CR124","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.bbi.2015.06.015","volume":"49","author":"N Morioka","year":"2015","unstructured":"Morioka N, Zhang FF, Nakamura Y, Kitamura T, Hisaoka-Nakashima K, Nakata Y (2015) Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice. Brain Behav Immun 49:293\u2013310","journal-title":"Brain Behav Immun"},{"issue":"5","key":"4562_CR125","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1471-4159.2011.07210.x","volume":"118","author":"JA Orellana","year":"2011","unstructured":"Orellana JA, Froger N, Ezan P, Jiang JX, Bennett MV, Naus CC et al (2011) ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels. J Neurochem 118(5):826\u2013840","journal-title":"J Neurochem"},{"issue":"2","key":"4562_CR126","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1172\/JCI81950","volume":"126","author":"BC Jiang","year":"2016","unstructured":"Jiang BC, Cao DL, Zhang X, Zhang ZJ, He LN, Li CH et al (2016) CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5. J Clin Invest 126(2):745\u2013761","journal-title":"J Clin Invest"},{"issue":"3","key":"4562_CR127","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0959-4388(00)00223-3","volume":"11","author":"P Bezzi","year":"2001","unstructured":"Bezzi P, Volterra A (2001) A neuron\u2013glia signalling network in the active brain. Curr Opin Neurobiol 11(3):387\u2013394","journal-title":"Curr Opin Neurobiol"},{"issue":"1","key":"4562_CR128","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12974-019-1524-2","volume":"16","author":"T Li","year":"2019","unstructured":"Li T, Chen X, Zhang C, Zhang Y, Yao W (2019) An update on reactive astrocytes in chronic pain. J Neuroinflammation 16(1):140","journal-title":"J Neuroinflammation"},{"key":"4562_CR129","doi-asserted-by":"crossref","unstructured":"Luo X, Tai WL, Sun L, Pan Z, Xia Z, Chung SK et al. (2016) Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain. Mol Pain 12","DOI":"10.1177\/1744806916636385"},{"issue":"Pt 3","key":"4562_CR130","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/brain\/aws330","volume":"136","author":"S Imai","year":"2013","unstructured":"Imai S, Ikegami D, Yamashita A, Shimizu T, Narita M, Niikura K et al (2013) Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain. Brain 136(Pt 3):828\u2013843","journal-title":"Brain"},{"issue":"3","key":"4562_CR131","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s12264-022-00961-3","volume":"39","author":"HJ Lu","year":"2023","unstructured":"Lu HJ, Gao YJ (2023) Astrocytes in chronic pain: cellular and molecular mechanisms. Neurosci Bull 39(3):425\u2013439","journal-title":"Neurosci Bull"},{"issue":"11","key":"4562_CR132","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41583-019-0218-1","volume":"20","author":"RR Ji","year":"2019","unstructured":"Ji RR, Donnelly CR, Nedergaard M (2019) Astrocytes in chronic pain and itch. Nat Rev Neurosci 20(11):667\u2013685","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"4562_CR133","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s12974-021-02268-y","volume":"18","author":"Y Rong","year":"2021","unstructured":"Rong Y, Ji C, Wang Z, Ge X, Wang J, Ye W et al (2021) Small extracellular vesicles encapsulating CCL2 from activated astrocytes induce microglial activation and neuronal apoptosis after traumatic spinal cord injury. J Neuroinflammation 18(1):196","journal-title":"J Neuroinflammation"},{"key":"4562_CR134","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.expneurol.2013.11.020","volume":"258","author":"AD Gaudet","year":"2014","unstructured":"Gaudet AD, Popovich PG (2014) Extracellular matrix regulation of inflammation in the healthy and injured spinal cord. Exp Neurol 258:24\u201334","journal-title":"Exp Neurol"},{"issue":"1\u20133","key":"4562_CR135","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1089\/ars.2021.0120","volume":"37","author":"JCT Chio","year":"2022","unstructured":"Chio JCT, Punjani N, Hejrati N, Zavvarian MM, Hong J, Fehlings MG (2022) Extracellular matrix and oxidative stress following traumatic spinal cord injury: physiological and pathophysiological roles and opportunities for therapeutic intervention. Antioxid Redox Signal 37(1\u20133):184\u2013207","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"4562_CR136","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.conb.2010.12.006","volume":"21","author":"A Dityatev","year":"2011","unstructured":"Dityatev A, Rusakov DA (2011) Molecular signals of plasticity at the tetrapartite synapse. Curr Opin Neurobiol 21(2):353\u2013359","journal-title":"Curr Opin Neurobiol"},{"issue":"2","key":"4562_CR137","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1517\/14728222.2014.960844","volume":"19","author":"A Kuhad","year":"2015","unstructured":"Kuhad A, Singh P, Chopra K (2015) Matrix metalloproteinases: potential therapeutic target for diabetic neuropathic pain. Expert Opin Ther Targets 19(2):177\u2013185","journal-title":"Expert Opin Ther Targets"},{"key":"4562_CR138","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.addr.2015.11.001","volume":"97","author":"AD Theocharis","year":"2016","unstructured":"Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK (2016) Extracellular matrix structure. Adv Drug Deliv Rev 97:4\u201327","journal-title":"Adv Drug Deliv Rev"},{"key":"4562_CR139","doi-asserted-by":"crossref","unstructured":"Bi Y, Duan W, Silver J (2024) Collagen I is a critical organizer of scarring and CNS regeneration failure. bioRxiv : the preprint server for biology","DOI":"10.1101\/2024.05.07.592424"},{"issue":"7","key":"4562_CR140","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/nm.4354","volume":"23","author":"M Hara","year":"2017","unstructured":"Hara M, Kobayakawa K, Ohkawa Y, Kumamaru H, Yokota K, Saito T et al (2017) Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury. Nat Med 23(7):818\u2013828","journal-title":"Nat Med"},{"issue":"1","key":"4562_CR141","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12974-024-03051-5","volume":"21","author":"C Wang","year":"2024","unstructured":"Wang C, Xu Y, Xu M, Sun C, Zhang X, Tao X et al (2024) SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury. J Neuroinflammation 21(1):57","journal-title":"J Neuroinflammation"},{"issue":"3","key":"4562_CR142","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/jnr.23498","volume":"93","author":"B Pan","year":"2015","unstructured":"Pan B, Yu H, Park J, Yu YP, Luo ZD, Hogan QH (2015) Painful nerve injury upregulates thrombospondin-4 expression in dorsal root ganglia. J Neurosci Res 93(3):443\u2013453","journal-title":"J Neurosci Res"},{"key":"4562_CR143","doi-asserted-by":"crossref","unstructured":"Emerson J, Delgado T, Girardi P, Johnson GVW (2023) Deletion of Transglutaminase 2 from mouse astrocytes significantly improves their ability to promote neurite outgrowth on an inhibitory matrix. Intl J Mol Sci 24(7)","DOI":"10.3390\/ijms24076058"},{"issue":"1","key":"4562_CR144","doi-asserted-by":"crossref","first-page":"e25285","DOI":"10.1002\/jnr.25285","volume":"102","author":"K Asiedu","year":"2024","unstructured":"Asiedu K (2024) Neurophysiology of corneal neuropathic pain and emerging pharmacotherapeutics. J Neurosci Res 102(1):e25285","journal-title":"J Neurosci Res"},{"key":"4562_CR145","doi-asserted-by":"crossref","unstructured":"Yu HL, Liu X, Yin Y, Liu XN, Feng YY, Tahir MM et al. (2024) Netrin-1 is an important mediator in microglia migration. Intl J Mol Sci. 25(13)","DOI":"10.3390\/ijms25137079"},{"key":"4562_CR146","doi-asserted-by":"crossref","first-page":"1393842","DOI":"10.3389\/fimmu.2024.1393842","volume":"15","author":"M Bottero","year":"2024","unstructured":"Bottero M, Pessina G, Bason C, Vigo T, Uccelli A, Ferrara G (2024) Nerve-Glial antigen 2: unmasking the enigmatic cellular identity in the central nervous system. Front Immunol 15:1393842","journal-title":"Front Immunol"},{"issue":"4","key":"4562_CR147","doi-asserted-by":"crossref","first-page":"113980","DOI":"10.1016\/j.celrep.2024.113980","volume":"43","author":"X Zhou","year":"2024","unstructured":"Zhou X, Zhu Y, Gao D, Li M, Lin L, Wang Z et al (2024) Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation. Cell Rep 43(4):113980","journal-title":"Cell Rep"},{"issue":"3","key":"4562_CR148","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1111\/ejn.16427","volume":"60","author":"SD Carey","year":"2024","unstructured":"Carey SD, Conant K, Maguire-Zeiss KA (2024) Short-term exposure to HIV Tat induces glial activation and changes in perineuronal nets. Eur J Neurosci 60(3):4303\u20134316","journal-title":"Eur J Neurosci"},{"key":"4562_CR149","doi-asserted-by":"crossref","first-page":"106614","DOI":"10.1016\/j.nbd.2024.106614","volume":"200","author":"SW Cheung","year":"2024","unstructured":"Cheung SW, Willis EF, Simmons DG, Bellingham MC, Noakes PG (2024) Phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing MMP-9 in TDP-43Q331K ALS model mice. Neurobiol Dis 200:106614","journal-title":"Neurobiol Dis"},{"issue":"8","key":"4562_CR150","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/s41593-024-01714-3","volume":"27","author":"BP Tewari","year":"2024","unstructured":"Tewari BP, Woo AM, Prim CE, Chaunsali L, Patel DC, Kimbrough IF et al (2024) Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice. Nat Neurosci 27(8):1475\u20131488","journal-title":"Nat Neurosci"},{"issue":"9","key":"4562_CR151","first-page":"1925","volume":"18","author":"Z Ahmed","year":"2023","unstructured":"Ahmed Z (2023) Reviving the use of inhibitors of matrix metalloproteases in spinal cord injury: a case for specificity. Neural Regen Res 18(9):1925\u20131930","journal-title":"Neural Regen Res"},{"key":"4562_CR152","unstructured":"Zong Y, Cao RL, Li YB, Hou WQ, Li SS, Xu LT, et al. (2024) [Mongolian medicine Naru-3 reduces neuroinflammation in maintenance stage of neuropathic pain by inhibiting astrocyte activation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China Journal of Chinese Materia Medica. 49(11):2991\u20133001"},{"issue":"6","key":"4562_CR153","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.ymthe.2017.03.020","volume":"25","author":"H Cai","year":"2017","unstructured":"Cai H, Ma Y, Jiang L, Mu Z, Jiang Z, Chen X et al (2017) Hypoxia response element-regulated MMP-9 promotes neurological recovery via glial scar degradation and angiogenesis in delayed stroke. Mol Ther J Am Soc Gene Ther 25(6):1448\u20131459","journal-title":"Mol Ther J Am Soc Gene Ther"},{"key":"4562_CR154","doi-asserted-by":"crossref","unstructured":"Obata H (2017) Analgesic mechanisms of antidepressants for neuropathic pain. Int J Mol Sci 18(11)","DOI":"10.3390\/ijms18112483"},{"issue":"9","key":"4562_CR155","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jpain.2016.05.010","volume":"17","author":"B Wilsey","year":"2016","unstructured":"Wilsey B, Marcotte TD, Deutsch R, Zhao H, Prasad H, Phan A (2016) An exploratory human laboratory experiment evaluating vaporized cannabis in the treatment of neuropathic pain from spinal cord injury and disease. J Pain 17(9):982\u20131000","journal-title":"J Pain"},{"issue":"9","key":"4562_CR156","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s40265-017-0747-8","volume":"77","author":"E Widerstr\u00f6m-Noga","year":"2017","unstructured":"Widerstr\u00f6m-Noga E (2017) Neuropathic Pain and spinal cord injury: phenotypes and pharmacological management. Drugs 77(9):967\u2013984","journal-title":"Drugs"},{"issue":"8","key":"4562_CR157","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.ejpain.2008.09.010","volume":"13","author":"R Wodarski","year":"2009","unstructured":"Wodarski R, Clark AK, Grist J, Marchand F, Malcangio M (2009) Gabapentin reverses microglial activation in the spinal cord of streptozotocin-induced diabetic rats. Eur J Pain 13(8):807\u2013811","journal-title":"Eur J Pain"},{"key":"4562_CR158","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1742-2094-11-7","volume":"11","author":"CY Huang","year":"2014","unstructured":"Huang CY, Chen YL, Li AH, Lu JC, Wang HL (2014) Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons. J Neuroinflammation 11:7","journal-title":"J Neuroinflammation"},{"issue":"1","key":"4562_CR159","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jphs.2023.06.002","volume":"153","author":"L Qiao","year":"2023","unstructured":"Qiao L, Tang Q, An Z, Qi J (2023) Minocycline relieves neuropathic pain in rats with spinal cord injury via activation of autophagy and suppression of PI3K\/Akt\/mTOR pathway. J Pharmacol Sci 153(1):12\u201321","journal-title":"J Pharmacol Sci"},{"key":"4562_CR160","doi-asserted-by":"crossref","unstructured":"Ciapa\u0142a K, Mika J (2023) Advances in neuropathic pain research: selected intracellular factors as potential targets for multidirectional analgesics. Pharmaceuticals (Basel). 16(11)","DOI":"10.3390\/ph16111624"},{"issue":"7","key":"4562_CR161","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1016\/j.bbadis.2018.04.006","volume":"1864","author":"JY Lee","year":"2018","unstructured":"Lee JY, Choi HY, Ju BG, Yune TY (2018) Estrogen alleviates neuropathic pain induced after spinal cord injury by inhibiting microglia and astrocyte activation. Biochim Biophys Acta Mol Basis Dis 1864(7):2472\u20132480","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"4562_CR162","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.brainresbull.2018.09.011","volume":"143","author":"S Fakhri","year":"2018","unstructured":"Fakhri S, Dargahi L, Abbaszadeh F, Jorjani M (2018) Astaxanthin attenuates neuroinflammation contributed to the neuropathic pain and motor dysfunction following compression spinal cord injury. Brain Res Bull 143:217\u2013224","journal-title":"Brain Res Bull"},{"issue":"6","key":"4562_CR163","first-page":"555","volume":"51","author":"A Wang","year":"2019","unstructured":"Wang A, Xu C (2019) The role of connexin43 in neuropathic pain induced by spinal cord injury. Acta Biochim Biophys Sin (Shanghai) 51(6):555\u2013561","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"4562_CR164","doi-asserted-by":"crossref","unstructured":"Hunter TJ, Videlefsky ZM, Ferreira Nakatani L, Zadina JE (2024) Comparison of morphine and endomorphin analog ZH853 for tolerance and immunomodulation in a rat model of neuropathic pain. J Pain 104607","DOI":"10.1016\/j.jpain.2024.104607"},{"issue":"1","key":"4562_CR165","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.clinthera.2007.01.013","volume":"29","author":"DM Tassone","year":"2007","unstructured":"Tassone DM, Boyce E, Guyer J, Nuzum D (2007) Pregabalin: a novel gamma-aminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders. Clin Ther 29(1):26\u201348","journal-title":"Clin Ther"},{"issue":"10","key":"4562_CR166","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1212\/01.wnl.0000244422.45278.ff","volume":"67","author":"PJ Siddall","year":"2006","unstructured":"Siddall PJ, Cousins MJ, Otte A, Griesing T, Chambers R, Murphy TK (2006) Pregabalin in central neuropathic pain associated with spinal cord injury: a placebo-controlled trial. Neurology 67(10):1792\u20131800","journal-title":"Neurology"},{"issue":"6","key":"4562_CR167","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1212\/WNL.0b013e318281546b","volume":"80","author":"DD Cardenas","year":"2013","unstructured":"Cardenas DD, Nieshoff EC, Suda K, Goto S, Sanin L, Kaneko T et al (2013) A randomized trial of pregabalin in patients with neuropathic pain due to spinal cord injury. Neurology 80(6):533\u2013539","journal-title":"Neurology"},{"issue":"1","key":"4562_CR168","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3344\/kjp.2020.33.1.3","volume":"33","author":"M Davari","year":"2020","unstructured":"Davari M, Amani B, Amani B, Khanijahani A, Akbarzadeh A, Shabestan R (2020) Pregabalin and gabapentin in neuropathic pain management after spinal cord injury: a systematic review and meta-analysis. Korean J Pain 33(1):3\u201312","journal-title":"Korean J Pain"},{"issue":"11","key":"4562_CR169","doi-asserted-by":"crossref","first-page":"e1193","DOI":"10.1212\/WNL.0000000000201709","volume":"100","author":"T Ushida","year":"2023","unstructured":"Ushida T, Katayama Y, Hiasa Y, Nishihara M, Tajima F, Katoh S et al (2023) Mirogabalin for central neuropathic pain after spinal cord injury: a randomized, double-blind, placebo-controlled, Phase 3 Study in Asia. Neurology 100(11):e1193\u2013e1206","journal-title":"Neurology"},{"issue":"3","key":"4562_CR170","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0304-3959(01)00483-3","volume":"96","author":"DD Cardenas","year":"2002","unstructured":"Cardenas DD, Warms CA, Turner JA, Marshall H, Brooke MM, Loeser JD (2002) Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial. Pain 96(3):365\u2013373","journal-title":"Pain"},{"issue":"12","key":"4562_CR171","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.apmr.2007.07.038","volume":"88","author":"DH Rintala","year":"2007","unstructured":"Rintala DH, Holmes SA, Courtade D, Fiess RN, Tastard LV, Loubser PG (2007) Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury. Arch Phys Med Rehabil 88(12):1547\u20131560","journal-title":"Arch Phys Med Rehabil"},{"issue":"4","key":"4562_CR172","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/ana.24605","volume":"79","author":"ZA Han","year":"2016","unstructured":"Han ZA, Song DH, Oh HM, Chung ME (2016) Botulinum toxin type A for neuropathic pain in patients with spinal cord injury. Ann Neurol 79(4):569\u2013578","journal-title":"Ann Neurol"},{"issue":"6","key":"4562_CR173","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jcyt.2018.03.032","volume":"20","author":"J Vaquero","year":"2018","unstructured":"Vaquero J, Zurita M, Rico MA, Aguayo C, Bonilla C, Marin E et al (2018) Intrathecal administration of autologous mesenchymal stromal cells for spinal cord injury: safety and efficacy of the 100\/3 guideline. Cytotherapy 20(6):806\u2013819","journal-title":"Cytotherapy"},{"issue":"4","key":"4562_CR174","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.apmr.2014.11.024","volume":"96","author":"JS Richards","year":"2015","unstructured":"Richards JS, Bombardier CH, Wilson CS, Chiodo AE, Brooks L, Tate DG et al (2015) Efficacy of venlafaxine XR for the treatment of pain in patients with spinal cord injury and major depression: a randomized, controlled trial. Arch Phys Med Rehabil 96(4):680\u2013689","journal-title":"Arch Phys Med Rehabil"},{"key":"4562_CR175","doi-asserted-by":"crossref","unstructured":"De Icco R, Perrotta A, Berra E, Allena M, Alfonsi E, Tamburin S et al (2019) OnabotulinumtoxinA reduces temporal pain processing at spinal level in patients with lower limb spasticity. Toxins (Basel) 11(6)","DOI":"10.3390\/toxins11060359"},{"key":"4562_CR176","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.brainresbull.2018.05.013","volume":"140","author":"H Kumru","year":"2018","unstructured":"Kumru H, Benito-Penalva J, Kofler M, Vidal J (2018) Analgesic effect of intrathecal baclofen bolus on neuropathic pain in spinal cord injury patients. Brain Res Bull 140:205\u2013211","journal-title":"Brain Res Bull"},{"issue":"5","key":"4562_CR177","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/PHM.0000000000000382","volume":"95","author":"K Min","year":"2016","unstructured":"Min K, Oh Y, Lee SH, Ryu JS (2016) Symptom-based treatment of neuropathic pain in spinal cord-injured patients: a randomized crossover clinical trial. Am J Phys Med Rehabil 95(5):330\u2013338","journal-title":"Am J Phys Med Rehabil"},{"issue":"1","key":"4562_CR178","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3171\/2017.11.SPINE17769","volume":"29","author":"N Derakhshanrad","year":"2018","unstructured":"Derakhshanrad N, Saberi H, Yekaninejad MS, Joghataei MT, Sheikhrezaei A (2018) Granulocyte-colony stimulating factor administration for neurological improvement in patients with postrehabilitation chronic incomplete traumatic spinal cord injuries: a double-blind randomized controlled clinical trial. J Neurosurg Spine 29(1):97\u2013107","journal-title":"J Neurosurg Spine"},{"issue":"2","key":"4562_CR179","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/sc.2016.123","volume":"55","author":"N Agarwal","year":"2017","unstructured":"Agarwal N, Joshi M (2017) Effectiveness of amitriptyline and lamotrigine in traumatic spinal cord injury-induced neuropathic pain: a randomized longitudinal comparative study. Spinal Cord 55(2):126\u2013130","journal-title":"Spinal Cord"},{"key":"4562_CR180","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jocn.2020.10.010","volume":"81","author":"L Zarepour","year":"2020","unstructured":"Zarepour L, Gharaylou Z, Hadjighassem M, Shafaghi L, Majedi H, Behzad E et al (2020) Preliminary study of analgesic effect of bumetanide on neuropathic pain in patients with spinal cord injury. J Clin Neurosci 81:477\u2013484","journal-title":"J Clin Neurosci"},{"issue":"1","key":"4562_CR181","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/pm\/pnac104","volume":"24","author":"A Olusanya","year":"2023","unstructured":"Olusanya A, Yearsley A, Brown N, Braun S, Hayes C, Rose E et al (2023) Capsaicin 8% patch for spinal cord injury focal neuropathic pain, a randomized controlled trial. Pain Med 24(1):71\u201378","journal-title":"Pain Med"},{"issue":"4","key":"4562_CR182","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/cpdd.253","volume":"5","author":"CN Sang","year":"2016","unstructured":"Sang CN, Barnabe KJ, Kern SE (2016) Phase IA clinical trial evaluating the tolerability, pharmacokinetics, and analgesic efficacy of an intrathecally administered neurotensin A analogue in central neuropathic pain following spinal cord injury. Clin Pharmacol Drug Dev 5(4):250\u2013258","journal-title":"Clin Pharmacol Drug Dev"},{"key":"4562_CR183","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13578-020-00405-3","volume":"10","author":"X Gui","year":"2020","unstructured":"Gui X, Wang H, Wu L, Tian S, Wang X, Zheng H et al (2020) Botulinum toxin type A promotes microglial M2 polarization and suppresses chronic constriction injury-induced neuropathic pain through the P2X7 receptor. Cell Biosci 10:45","journal-title":"Cell Biosci"},{"issue":"1","key":"4562_CR184","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00586-012-2556-9","volume":"22","author":"K Kato","year":"2013","unstructured":"Kato K, Yamazaki M, Okawa A, Furuya T, Sakuma T, Takahashi H et al (2013) Intravenous administration of granulocyte colony-stimulating factor for treating neuropathic pain associated with compression myelopathy: a phase I and IIa clinical trial. Eur Spine J 22(1):197\u2013204","journal-title":"Eur Spine J"},{"key":"4562_CR185","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.bbi.2014.06.015","volume":"42","author":"NN Burke","year":"2014","unstructured":"Burke NN, Kerr DM, Moriarty O, Finn DP, Roche M (2014) Minocycline modulates neuropathic pain behaviour and cortical M1\u2013M2 microglial gene expression in a rat model of depression. Brain Behav Immun 42:147\u2013156","journal-title":"Brain Behav Immun"},{"issue":"2","key":"4562_CR186","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/ALN.0000000000000508","volume":"122","author":"P Vanelderen","year":"2015","unstructured":"Vanelderen P, Van Zundert J, Kozicz T, Puylaert M, De Vooght P, Mestrum R et al (2015) Effect of minocycline on lumbar radicular neuropathic pain: a randomized, placebo-controlled, double-blind clinical trial with amitriptyline as a comparator. Anesthesiology 122(2):399\u2013406","journal-title":"Anesthesiology"},{"key":"4562_CR187","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neulet.2013.03.014","volume":"543","author":"LF Bastos","year":"2013","unstructured":"Bastos LF, Godin AM, Zhang Y, Jarussophon S, Ferreira BC, Machado RR et al (2013) A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4. Neurosci Lett 543:157\u2013162","journal-title":"Neurosci Lett"},{"key":"4562_CR188","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2147\/JPR.S292824","volume":"14","author":"DA Shin","year":"2021","unstructured":"Shin DA, Kim TU, Chang MC (2021) Minocycline for controlling neuropathic pain: a systematic narrative review of studies in humans. J Pain Res 14:139\u2013145","journal-title":"J Pain Res"},{"issue":"11","key":"4562_CR189","doi-asserted-by":"crossref","first-page":"e1129","DOI":"10.1097\/j.pain.0000000000002643","volume":"163","author":"Y Tu","year":"2022","unstructured":"Tu Y, Muley MM, Beggs S, Salter MW (2022) Microglia-independent peripheral neuropathic pain in male and female mice. Pain 163(11):e1129\u2013e1144","journal-title":"Pain"},{"issue":"7","key":"4562_CR190","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s10072-014-1647-2","volume":"35","author":"A Syngle","year":"2014","unstructured":"Syngle A, Verma I, Krishan P, Garg N, Syngle V (2014) Minocycline improves peripheral and autonomic neuropathy in type 2 diabetes: MIND study. Neurol Sci 35(7):1067\u20131073","journal-title":"Neurol Sci"},{"key":"4562_CR191","doi-asserted-by":"crossref","unstructured":"Narang T, Arshdeep, Dogra S (2017) Minocycline in leprosy patients with recent onset clinical nerve function impairment. Dermatol Ther 30(1)","DOI":"10.1111\/dth.12404"},{"issue":"2","key":"4562_CR192","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1213\/ANE.0b013e318273f71c","volume":"116","author":"SP Cohen","year":"2013","unstructured":"Cohen SP, Galvagno SM, Plunkett A, Harris D, Kurihara C, Turabi A et al (2013) A multicenter, randomized, controlled study evaluating preventive etanercept on postoperative pain after inguinal hernia repair. Anesth Analg 116(2):455\u2013462","journal-title":"Anesth Analg"},{"issue":"Suppl 1","key":"4562_CR193","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1093\/pm\/pnz075","volume":"20","author":"D Bates","year":"2019","unstructured":"Bates D, Schultheis BC, Hanes MC, Jolly SM, Chakravarthy KV, Deer TR et al (2019) A comprehensive algorithm for management of neuropathic pain. Pain Med 20(Suppl 1):S2-s12","journal-title":"Pain Med"},{"key":"4562_CR194","doi-asserted-by":"crossref","unstructured":"Lunn MP, Hughes RA, Wiffen PJ. Duloxetine for treating painful neuropathy or chronic pain. Cochrane Database Syst Rev. 2009(4):Cd007115","DOI":"10.1002\/14651858.CD007115.pub2"},{"issue":"2","key":"4562_CR195","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","volume":"14","author":"NB Finnerup","year":"2015","unstructured":"Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH et al (2015) Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol 14(2):162\u2013173","journal-title":"Lancet Neurol"},{"key":"4562_CR196","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.2147\/JPR.S138099","volume":"10","author":"JV Holbech","year":"2017","unstructured":"Holbech JV, Jung A, Jonsson T, Wanning M, Bredahl C, Bach FW (2017) Combination treatment of neuropathic pain: Danish expert recommendations based on a Delphi process. J Pain Res 10:1467\u20131475","journal-title":"J Pain Res"},{"issue":"11","key":"4562_CR197","first-page":"844","volume":"63","author":"A Mu","year":"2017","unstructured":"Mu A, Weinberg E, Moulin DE, Clarke H (2017) Pharmacologic management of chronic neuropathic pain: review of the Canadian Pain Society consensus statement. Can Fam Physician 63(11):844\u2013852","journal-title":"Can Fam Physician"},{"issue":"2","key":"4562_CR198","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/j.pain.0000000000002688","volume":"164","author":"M Balanaser","year":"2023","unstructured":"Balanaser M, Carley M, Baron R, Finnerup NB, Moore RA, Rowbotham MC et al (2023) Combination pharmacotherapy for the treatment of neuropathic pain in adults: systematic review and meta-analysis. Pain 164(2):230\u2013251","journal-title":"Pain"},{"key":"4562_CR199","doi-asserted-by":"crossref","unstructured":"Serrano Afonso A, Carnaval T, Videla C\u00e9s S (2021) Combination therapy for neuropathic pain: a review of recent evidence. J Clin Med 10(16)","DOI":"10.3390\/jcm10163533"},{"key":"4562_CR200","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3389\/fphar.2017.00245","volume":"8","author":"AM Ziemba","year":"2017","unstructured":"Ziemba AM, Gilbert RJ (2017) Biomaterials for local, controlled drug delivery to the injured spinal cord. Front Pharmacol 8:245","journal-title":"Front Pharmacol"},{"key":"4562_CR201","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jconrel.2013.11.001","volume":"174","author":"S Papa","year":"2014","unstructured":"Papa S, Ferrari R, De Paola M, Rossi F, Mariani A, Caron I et al (2014) Polymeric nanoparticle system to target activated microglia\/macrophages in spinal cord injury. J Control Release 174:15\u201326","journal-title":"J Control Release"},{"key":"4562_CR202","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.biomaterials.2015.10.015","volume":"75","author":"S Papa","year":"2016","unstructured":"Papa S, Caron I, Erba E, Panini N, De Paola M, Mariani A et al (2016) Early modulation of pro-inflammatory microglia by minocycline loaded nanoparticles confers long lasting protection after spinal cord injury. Biomaterials 75:13\u201324","journal-title":"Biomaterials"},{"key":"4562_CR203","doi-asserted-by":"crossref","first-page":"641588","DOI":"10.3389\/fimmu.2021.641588","volume":"12","author":"JR Bethea","year":"2021","unstructured":"Bethea JR, Fischer R (2021) Role of peripheral immune cells for development and recovery of chronic pain. Front Immunol 12:641588","journal-title":"Front Immunol"},{"issue":"1","key":"4562_CR204","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/eji.201444823","volume":"45","author":"L Xie","year":"2015","unstructured":"Xie L, Choudhury GR, Winters A, Yang SH, Jin K (2015) Cerebral regulatory T cells restrain microglia\/macrophage-mediated inflammatory responses via IL-10. Eur J Immunol 45(1):180\u2013191","journal-title":"Eur J Immunol"},{"issue":"8","key":"4562_CR205","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1111\/cns.14161","volume":"29","author":"R Liu","year":"2023","unstructured":"Liu R, Li Y, Wang Z, Chen P, Xie Y, Qu W et al (2023) Regulatory T cells promote functional recovery after spinal cord injury by alleviating microglia inflammation via STAT3 inhibition. CNS Neurosci Ther 29(8):2129\u20132144","journal-title":"CNS Neurosci Ther"},{"issue":"3","key":"4562_CR206","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.nbd.2012.07.008","volume":"48","author":"W Zhao","year":"2012","unstructured":"Zhao W, Beers DR, Liao B, Henkel JS, Appel SH (2012) Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms. Neurobiol Dis 48(3):418\u2013428","journal-title":"Neurobiol Dis"},{"key":"4562_CR207","doi-asserted-by":"crossref","unstructured":"Fiore NT, Keating BA, Chen Y, Williams SI, Moalem-Taylor G (2023) Differential effects of regulatory T cells in the meninges and spinal cord of male and female mice with neuropathic pain. Cells 12(18)","DOI":"10.3390\/cells12182317"},{"issue":"49","key":"4562_CR208","doi-asserted-by":"crossref","first-page":"19446","DOI":"10.1073\/pnas.0706832104","volume":"104","author":"MM Tiemessen","year":"2007","unstructured":"Tiemessen MM, Jagger AL, Evans HG, van Herwijnen MJ, John S, Taams LS (2007) CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes\/macrophages. Proc Natl Acad Sci U S A 104(49):19446\u201319451","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"4562_CR209","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1097\/j.pain.0000000000001879","volume":"161","author":"M Davoli-Ferreira","year":"2020","unstructured":"Davoli-Ferreira M, de Lima KA, Fonseca MM, Guimar\u00e3es RM, Gomes FI, Cavallini MC et al (2020) Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury. Pain 161(8):1730\u20131743","journal-title":"Pain"},{"issue":"8","key":"4562_CR210","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00403-013-1367-0","volume":"305","author":"Q Xing","year":"2013","unstructured":"Xing Q, Hu D, Shi F, Chen F (2013) Role of regulatory T cells in patients with acute herpes zoster and relationship to postherpetic neuralgia. Arch Dermatol Res 305(8):715\u2013722","journal-title":"Arch Dermatol Res"},{"issue":"4","key":"4562_CR211","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/imm.12451","volume":"144","author":"LC Davies","year":"2015","unstructured":"Davies LC, Taylor PR (2015) Tissue-resident macrophages: then and now. Immunology 144(4):541\u2013548","journal-title":"Immunology"},{"issue":"6","key":"4562_CR212","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1089\/neu.2018.5819","volume":"36","author":"SJ Chhaya","year":"2019","unstructured":"Chhaya SJ, Quiros-Molina D, Tamashiro-Orrego AD, Houl\u00e9 JD, Detloff MR (2019) Exercise-induced changes to the macrophage response in the dorsal root ganglia prevent neuropathic pain after spinal cord injury. J Neurotrauma 36(6):877\u2013890","journal-title":"J Neurotrauma"},{"issue":"4","key":"4562_CR213","doi-asserted-by":"crossref","first-page":"109466","DOI":"10.1016\/j.isci.2024.109466","volume":"27","author":"S Yamamoto","year":"2024","unstructured":"Yamamoto S, Hashidate-Yoshida T, Yoshinari Y, Shimizu T, Shindou H (2024) Macrophage\/microglia-producing transient increase of platelet-activating factor is involved in neuropathic pain. iScience. 27(4):109466","journal-title":"iScience."},{"issue":"4","key":"4562_CR214","doi-asserted-by":"crossref","first-page":"e14657","DOI":"10.1111\/cns.14657","volume":"30","author":"W Si","year":"2024","unstructured":"Si W, Chen Z, Bei J, Chang S, Zheng Y, Gao L et al (2024) Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34\/CSF1R. CNS Neurosci Ther 30(4):e14657","journal-title":"CNS Neurosci Ther"},{"key":"4562_CR215","doi-asserted-by":"crossref","first-page":"116769","DOI":"10.1016\/j.biopha.2024.116769","volume":"175","author":"CT Huang","year":"2024","unstructured":"Huang CT, Wang LK, Lue JH, Chen SH, Tsai YJ (2024) Lactobacillus plantarum intake mitigates neuropathic pain behavior via enhancing macrophage M2 polarization in a rat model of peripheral neuropathy. Biomed Pharmacother 175:116769","journal-title":"Biomed Pharmacother"},{"key":"4562_CR216","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/978-1-60327-323-7_25","volume":"617","author":"D Siniscalco","year":"2010","unstructured":"Siniscalco D (2010) Transplantation of human mesenchymal stem cells in the study of neuropathic pain. Methods Mol Biol 617:337\u2013345","journal-title":"Methods Mol Biol"},{"issue":"12","key":"4562_CR217","doi-asserted-by":"crossref","first-page":"e32689","DOI":"10.1016\/j.heliyon.2024.e32689","volume":"10","author":"X Xu","year":"2024","unstructured":"Xu X, Chen H, Qiu Y, Chen Y, Liu J, Zeng B et al (2024) Intravenous application of human umbilical cord mesenchymal stem cells alleviate neuropathic pain by suppressing microglia activation in rats. Heliyon 10(12):e32689","journal-title":"Heliyon"},{"issue":"1","key":"4562_CR218","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s12951-022-01522-6","volume":"20","author":"T Hua","year":"2022","unstructured":"Hua T, Yang M, Song H, Kong E, Deng M, Li Y et al (2022) Huc-MSCs-derived exosomes attenuate inflammatory pain by regulating microglia pyroptosis and autophagy via the miR-146a-5p\/TRAF6 axis. J Nanobiotechnology 20(1):324","journal-title":"J Nanobiotechnology"},{"key":"4562_CR219","doi-asserted-by":"crossref","unstructured":"Kao Y, Zhu H, Yang Y, Shen W, Song W, Zhang R et al (2023) CREB1 Facilitates GABAergic neural differentiation of human mesenchymal stem cells through BRN2 for pain alleviation and locomotion recovery after spinal cord injury. Cells 13(1)","DOI":"10.3390\/cells13010067"},{"issue":"6","key":"4562_CR220","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1002\/jnr.23883","volume":"95","author":"AM Taylor","year":"2017","unstructured":"Taylor AM, Mehrabani S, Liu S, Taylor AJ, Cahill CM (2017) Topography of microglial activation in sensory- and affect-related brain regions in chronic pain. J Neurosci Res 95(6):1330\u20131335","journal-title":"J Neurosci Res"},{"key":"4562_CR221","doi-asserted-by":"crossref","first-page":"109806","DOI":"10.1016\/j.diabres.2022.109806","volume":"186","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Li Q, Liu S, Zheng H, Ji L, Yi N et al (2022) Glucagon-like peptide-1 receptor agonist attenuates diabetic neuropathic pain via inhibition of NOD-like receptor protein 3 inflammasome in brain microglia. Diabetes Res Clin Pract 186:109806","journal-title":"Diabetes Res Clin Pract"},{"key":"4562_CR222","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fimmu.2020.00294","volume":"11","author":"S Xu","year":"2020","unstructured":"Xu S, Lu J, Shao A, Zhang JH, Zhang J (2020) Glial Cells: Role of the immune response in ischemic stroke. Front Immunol 11:294","journal-title":"Front Immunol"},{"issue":"2","key":"4562_CR223","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.expneurol.2011.08.018","volume":"234","author":"M Calvo","year":"2012","unstructured":"Calvo M, Bennett DL (2012) The mechanisms of microgliosis and pain following peripheral nerve injury. Exp Neurol 234(2):271\u2013282","journal-title":"Exp Neurol"},{"issue":"6601","key":"4562_CR224","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.abl6773","volume":"377","author":"S Tansley","year":"2022","unstructured":"Tansley S, Gu N, Guzm\u00e1n AU, Cai W, Wong C, Lister KC et al (2022) Microglia-mediated degradation of perineuronal nets promotes pain. Science 377(6601):80\u201386","journal-title":"Science"},{"issue":"1","key":"4562_CR225","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-022-01162-0","volume":"7","author":"CE M\u00fcller","year":"2022","unstructured":"M\u00fcller CE, Claff T (2022) Activated microglia nibbling glycosaminoglycans from spinal cord perineural nets: a new mechanism for neuropathic pain. Signal Transduct Target Ther 7(1):333","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"4562_CR226","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s11658-023-00474-5","volume":"28","author":"J Du","year":"2023","unstructured":"Du J, Cheng N, Deng Y, Xiang P, Liang J, Zhang Z et al (2023) Astrocyte senescence-like response related to peripheral nerve injury-induced neuropathic pain. Cell Mol Biol Lett 28(1):65","journal-title":"Cell Mol Biol Lett"},{"key":"4562_CR227","doi-asserted-by":"crossref","first-page":"174480692110066","DOI":"10.1177\/17448069211006603","volume":"17","author":"O Tsymbalyuk","year":"2021","unstructured":"Tsymbalyuk O, Gerzanich V, Mumtaz A, Andhavarapu S, Ivanova S, Makar TK et al (2021) SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury. Mol Pain 17:17448069211006604","journal-title":"Mol Pain"},{"key":"4562_CR228","doi-asserted-by":"crossref","unstructured":"Chen Y, Song XJ (2024) Diabetic neuropathic pain: directions for exploring treatments. Biomedicines 12(3)","DOI":"10.3390\/biomedicines12030589"},{"key":"4562_CR229","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejphar.2014.01.057","volume":"728","author":"D Wang","year":"2014","unstructured":"Wang D, Couture R, Hong Y (2014) Activated microglia in the spinal cord underlies diabetic neuropathic pain. Eur J Pharmacol 728:59\u201366","journal-title":"Eur J Pharmacol"},{"issue":"24","key":"4562_CR230","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1523\/JNEUROSCI.2566-20.2021","volume":"41","author":"J Lu","year":"2021","unstructured":"Lu J, Yang L, Xu Y, Ai L, Chen J, Xiong F et al (2021) The modulatory effect of motor cortex astrocytes on diabetic neuropathic pain. J Neurosci 41(24):5287\u20135302","journal-title":"J Neurosci"},{"issue":"2","key":"4562_CR231","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ejp.922","volume":"21","author":"XT Deng","year":"2017","unstructured":"Deng XT, Wu MZ, Xu N, Ma PC, Song XJ (2017) Activation of ephrinB-EphB receptor signalling in rat spinal cord contributes to maintenance of diabetic neuropathic pain. Eur J Pain 21(2):278\u2013288","journal-title":"Eur J Pain"},{"key":"4562_CR232","doi-asserted-by":"crossref","unstructured":"Qu SY, Wang HZ, Hu QQ, Ma YQ, Kang YR, Ma LQ et al (2023) Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation. Purinergic Signal","DOI":"10.1007\/s11302-023-09972-9"},{"key":"4562_CR233","doi-asserted-by":"crossref","unstructured":"Zhou D-m, Zhuang Y, Chen W-j, Li W, Miao B (2018) Effects of duloxetine on the toll-like receptor 4 signaling pathway in spinal dorsal horn in a rat model of diabetic neuropathic pain. Pain Med. 19(3):580\u20138","DOI":"10.1093\/pm\/pnx125"},{"issue":"6640","key":"4562_CR234","doi-asserted-by":"crossref","first-page":"eabo7649","DOI":"10.1126\/science.abo7649","volume":"380","author":"G Castellani","year":"2023","unstructured":"Castellani G, Croese T, Peralta Ramos JM, Schwartz M (2023) Transforming the understanding of brain immunity. Science. 380(6640):eabo7649","journal-title":"Science."},{"key":"4562_CR235","doi-asserted-by":"crossref","unstructured":"Rauf A, Badoni H, Abu-Izneid T, Olatunde A, Rahman MM, Painuli S et al (2022) Neuroinflammatory markers: key indicators in the pathology of neurodegenerative diseases. Molecules 27(10)","DOI":"10.3390\/molecules27103194"},{"key":"4562_CR236","doi-asserted-by":"crossref","unstructured":"Schildge S, Bohrer C, Beck K, Schachtrup C (2013) Isolation and culture of mouse cortical astrocytes. J Vis Exp (71)","DOI":"10.3791\/50079-v"},{"issue":"01","key":"4562_CR237","first-page":"25","volume":"55","author":"L Yuan","year":"2024","unstructured":"Yuan L, Li Z, Yang H, Liu Z, He J, Wan W (2024) Panax notoginseng saponins inhibit the activation of astrocytes in mice and alleviate inflammatory pain caused by complete Freund\u2019s adjuvant. J Anat 55(01):25\u201331","journal-title":"J Anat"},{"issue":"5","key":"4562_CR238","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41573-022-00390-x","volume":"21","author":"HG Lee","year":"2022","unstructured":"Lee HG, Wheeler MA, Quintana FJ (2022) Function and therapeutic value of astrocytes in neurological diseases. Nat Rev Drug Discov 21(5):339\u2013358","journal-title":"Nat Rev Drug Discov"},{"issue":"5","key":"4562_CR239","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/14728222.2021.1934447","volume":"25","author":"MC Scott","year":"2021","unstructured":"Scott MC, Bedi SS, Olson SD, Sears CM, Cox CS (2021) Microglia as therapeutic targets after neurological injury: strategy for cell therapy. Expert Opin Ther Targets 25(5):365\u2013380","journal-title":"Expert Opin Ther Targets"},{"key":"4562_CR240","first-page":"357","volume":"4","author":"L Chen","year":"2019","unstructured":"Chen L, Ma Y, Liu Y, Shen J, Chen H, Tang L et al (2019) A preliminary exploration of the role of microglia in nerve injury in fetal rats with spinal cord bulge. Chinese J Pediatric Surg 4:357\u2013362","journal-title":"Chinese J Pediatric Surg"},{"key":"4562_CR241","unstructured":"WeiHong Zhang DW (2002) Expression of glial fibrillary acidic protein after spinal cord injury and its significance. Journal of Nanjing Medical University (Natural Science Edition). (01):17\u20139+1"},{"key":"4562_CR242","doi-asserted-by":"crossref","unstructured":"Ruan C, Elyaman W (2022) A new understanding of TMEM119 as a marker of microglia. Front Cell Neurosci 16","DOI":"10.3389\/fncel.2022.902372"},{"key":"4562_CR243","first-page":"042","volume":"003","author":"C Peng","year":"2022","unstructured":"Peng C, Fu Y, Zhu F, Xia R, Xia W (2022) Recent advances in the function of spinal CD11c+ microglia in neuropathic pain. Lab Animals Compar Med 003:042","journal-title":"Lab Animals Compar Med"},{"issue":"26","key":"4562_CR244","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.2174\/0929867323666160607120124","volume":"23","author":"K Popiolek-Barczyk","year":"2016","unstructured":"Popiolek-Barczyk K, Mika J (2016) Targeting the microglial signaling pathways: new insights in the modulation of neuropathic pain. Curr Med Chem 23(26):2908\u20132928","journal-title":"Curr Med Chem"},{"issue":"4","key":"4562_CR245","first-page":"235","volume":"40","author":"Z Tao","year":"2020","unstructured":"Tao Z (2020) P2X7R antagonist inhibits oxygen sugar deprivation-induced apoptosis in primary neurons via p38MAPK. J Xuzhou Med Univ 40(4):235\u2013239","journal-title":"J Xuzhou Med Univ"},{"issue":"1","key":"4562_CR246","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12974-024-03143-2","volume":"21","author":"X Hou","year":"2024","unstructured":"Hou X, Qu X, Chen W, Sang X, Ye Y, Wang C et al (2024) CD36 deletion prevents white matter injury by modulating microglia polarization through the Traf5-MAPK signal pathway. J Neuroinflammation 21(1):148","journal-title":"J Neuroinflammation"},{"key":"4562_CR247","doi-asserted-by":"crossref","first-page":"176566","DOI":"10.1016\/j.ejphar.2024.176566","volume":"973","author":"R Zhu","year":"2024","unstructured":"Zhu R, Zhang Y, He W, Sun Y, Zhao X, Yan Y et al (2024) Wogonoside alleviates microglia-mediated neuroinflammation via TLR4\/MyD88\/NF-\u03baB signaling axis after spinal cord injury. Eur J Pharmacol 973:176566","journal-title":"Eur J Pharmacol"},{"issue":"01","key":"4562_CR248","first-page":"43","volume":"17","author":"G Wang","year":"2020","unstructured":"Wang G, Cheng Z, Yang B, Li H, He X (2020) Changes in chondroitin sulfate proteoglycan and GFAP expression after spinal cord injury. Bio-orthopedic Mater Clin Res 17(01):43\u201346","journal-title":"Bio-orthopedic Mater Clin Res"},{"issue":"3","key":"4562_CR249","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.neuroscience.2006.02.070","volume":"140","author":"FY Tanga","year":"2006","unstructured":"Tanga FY, Raghavendra V, Nutile-McMenemy N, Marks A, Deleo JA (2006) Role of astrocytic S100beta in behavioral hypersensitivity in rodent models of neuropathic pain. Neuroscience 140(3):1003\u20131010","journal-title":"Neuroscience"},{"issue":"13","key":"4562_CR250","doi-asserted-by":"crossref","first-page":"107834","DOI":"10.1016\/j.celrep.2020.107834","volume":"31","author":"AL Vivinetto","year":"2020","unstructured":"Vivinetto AL, Kim ID, Goldberg DC, Fones L, Brown E, Tarabykin VS et al (2020) Zeb2 is a regulator of astrogliosis and functional recovery after CNS injury. Cell Rep 31(13):107834","journal-title":"Cell Rep"},{"issue":"8","key":"4562_CR251","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1111\/cns.14170","volume":"29","author":"W Zhang","year":"2023","unstructured":"Zhang W, Jia M, Lian J, Lu S, Zhou J, Fan Z et al (2023) Inhibition of TANK-binding kinase1 attenuates the astrocyte-mediated neuroinflammatory response through YAP signaling after spinal cord injury. CNS Neurosci Ther 29(8):2206\u20132222","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"4562_CR252","doi-asserted-by":"crossref","first-page":"557","DOI":"10.4103\/NRR.NRR-D-23-01130","volume":"20","author":"J Chen","year":"2025","unstructured":"Chen J, Zeng X, Wang L, Zhang W, Li G, Cheng X et al (2025) Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury. Neural Regen Res 20(2):557\u2013573","journal-title":"Neural Regen Res"},{"issue":"1","key":"4562_CR253","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrn2533","volume":"10","author":"ED Milligan","year":"2009","unstructured":"Milligan ED, Watkins LR (2009) Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci 10(1):23\u201336","journal-title":"Nat Rev Neurosci"},{"key":"4562_CR254","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.2147\/DDDT.S459757","volume":"18","author":"Y Shao","year":"2024","unstructured":"Shao Y, Chen Y, Lan X, Lu J, Tang G, Tang S et al (2024) Morin regulates M1\/M2 microglial polarization via NF-\u03baB p65 to alleviate vincristine-induced neuropathic pain. Drug Des Dev Ther 18:3143\u20133156","journal-title":"Drug Des Dev Ther"},{"issue":"1","key":"4562_CR255","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11481-024-10117-x","volume":"19","author":"Q Xia","year":"2024","unstructured":"Xia Q, Yu Y, Zhan G, Zhang X, Gao S, Han T et al (2024) The sirtuin 5 inhibitor MC3482 ameliorates microglia-induced neuroinflammation following ischaemic stroke by upregulating the succinylation level of annexin-A1. J Neuroimmune Pharmacol Official J Soc NeuroImmune Pharmacol 19(1):17","journal-title":"J Neuroimmune Pharmacol Official J Soc NeuroImmune Pharmacol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04562-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04562-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04562-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T05:09:40Z","timestamp":1741064980000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04562-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,29]]},"references-count":255,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["4562"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04562-1","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,29]]},"assertion":[{"value":"24 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}