{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:57:28Z","timestamp":1787165848810,"version":"build-2736575974"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"crossref","award":["GR-2021-12374579"],"award-info":[{"award-number":["GR-2021-12374579"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"crossref","award":["GR-2018-12365706"],"award-info":[{"award-number":["GR-2018-12365706"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"crossref","award":["GR-2021-12374579"],"award-info":[{"award-number":["GR-2021-12374579"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"crossref","award":["GR-2018-12365706"],"award-info":[{"award-number":["GR-2018-12365706"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004710","name":"Fondazione Umberto Veronesi","doi-asserted-by":"publisher","award":["post-doctoral fellowship"],"award-info":[{"award-number":["post-doctoral fellowship"]}],"id":[{"id":"10.13039\/501100004710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana Ricerca sul Cancro","doi-asserted-by":"crossref","award":["post-doctoral fellowship"],"award-info":[{"award-number":["post-doctoral fellowship"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of University","award":["PRIN 2022"],"award-info":[{"award-number":["PRIN 2022"]}]},{"name":"Ministry of University","award":["PRIN 2017"],"award-info":[{"award-number":["PRIN 2017"]}]},{"DOI":"10.13039\/501100002426","name":"Telethon Foundation","doi-asserted-by":"crossref","award":["GGP20055"],"award-info":[{"award-number":["GGP20055"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s12035-024-04605-7","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T21:18:17Z","timestamp":1732655897000},"page":"5640-5649","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["High Expression of SMN circ4-2b-3 in SMA I Children Treated with Nusinersen is Associated with Improved Motor Outcomes"],"prefix":"10.1007","volume":"62","author":[{"given":"Marika","family":"Guerra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Marini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria","family":"Pagliarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Pitolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Coratti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Bonvissuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bravetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Pane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Mercuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Sette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6777-1721","authenticated-orcid":false,"given":"Maria Carmela","family":"Pera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"issue":"1","key":"4605_CR1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41572-022-00380-8","volume":"8","author":"E Mercuri","year":"2022","unstructured":"Mercuri E, Sumner CJ, Muntoni F, Darras BT, Finkel RS (2022) Spinal muscular atrophy. Nat Rev Dis Primers 8(1):52. https:\/\/doi.org\/10.1038\/s41572-022-00380-8","journal-title":"Nat Rev Dis Primers"},{"issue":"11","key":"4605_CR2","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1212\/WNL.0000000000201654","volume":"100","author":"G Coratti","year":"2023","unstructured":"Coratti G, Ricci M, Capasso A, D\u2019amico A, Sansone V, Bruno C et al (2023) Prevalence of spinal muscular atrophy in the era of disease-modifying therapies: an Italian nationwide survey. Neurology 100(11):522\u2013528. https:\/\/doi.org\/10.1212\/WNL.0000000000201654","journal-title":"Neurology"},{"issue":"1","key":"4605_CR3","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","volume":"80","author":"S Lefebvre","year":"1995","unstructured":"Lefebvre S, Burglen L, Reboullet S, Clermont O, Burlet P, Viollet L et al (1995) Identification and characterization of a spinal muscular atrophy-determining gene. Cell 80(1):155\u2013165. https:\/\/doi.org\/10.1016\/0092-8674(95)90460-3","journal-title":"Cell"},{"issue":"4","key":"4605_CR4","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/ng1207","volume":"34","author":"T Kashima","year":"2003","unstructured":"Kashima T, Manley JL (2003) A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy. Nat Genet 34(4):460\u2013463. https:\/\/doi.org\/10.1038\/ng1207","journal-title":"Nat Genet"},{"issue":"1","key":"4605_CR5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1083\/jcb.201502059","volume":"211","author":"V Pagliarini","year":"2015","unstructured":"Pagliarini V, Pelosi L, Bustamante MB, Nobili A, Berardinelli MG, D\u2019Amelio M et al (2015) SAM68 is a physiological regulator of SMN2 splicing in spinal muscular atrophy. J Cell Biol 211(1):77\u201390. https:\/\/doi.org\/10.1083\/jcb.201502059","journal-title":"J Cell Biol"},{"issue":"5","key":"4605_CR6","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1111\/ahg.12031","volume":"77","author":"DK Nurputra","year":"2013","unstructured":"Nurputra DK, Lai PS, Harahap NI, Morikawa S, Yamamoto T, Nishimura N et al (2013) Spinal muscular atrophy: from gene discovery to clinical trials. Ann Hum Genet 77(5):435\u2013463. https:\/\/doi.org\/10.1111\/ahg.12031","journal-title":"Ann Hum Genet"},{"issue":"4","key":"4605_CR7","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1007\/s00439-006-0156-7","volume":"119","author":"B Wirth","year":"2006","unstructured":"Wirth B, Brichta L, Schrank B, Lochmuller H, Blick S, Baasner A et al (2006) Mildly affected patients with spinal muscular atrophy are partially protected by an increased SMN2 copy number. Hum Genet 119(4):422\u2013428. https:\/\/doi.org\/10.1007\/s00439-006-0156-7","journal-title":"Hum Genet"},{"issue":"10","key":"4605_CR8","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1212\/WNL.0000000000002445","volume":"86","author":"CA Chiriboga","year":"2016","unstructured":"Chiriboga CA, Swoboda KJ, Darras BT, Iannaccone ST, Montes J, De Vivo DC et al (2016) Results from a phase 1 study of nusinersen (ISIS-SMN(Rx)) in children with spinal muscular atrophy. Neurology 86(10):890\u2013897. https:\/\/doi.org\/10.1212\/WNL.0000000000002445","journal-title":"Neurology"},{"issue":"6","key":"4605_CR9","doi-asserted-by":"publisher","first-page":"e00447","DOI":"10.1002\/prp2.447","volume":"6","author":"A Poirier","year":"2018","unstructured":"Poirier A, Weetall M, Heinig K, Bucheli F, Schoenlein K, Alsenz J et al (2018) Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs. Pharmacol Res Perspect 6(6):e00447. https:\/\/doi.org\/10.1002\/prp2.447","journal-title":"Pharmacol Res Perspect"},{"issue":"7","key":"4605_CR10","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1007\/s00431-023-04883-8","volume":"182","author":"L Antonaci","year":"2023","unstructured":"Antonaci L, Pera MC, Mercuri E (2023) New therapies for spinal muscular atrophy: where we stand and what is next. Eur J Pediatr 182(7):2935\u20132942. https:\/\/doi.org\/10.1007\/s00431-023-04883-8","journal-title":"Eur J Pediatr"},{"issue":"12","key":"4605_CR11","doi-asserted-by":"publisher","first-page":"8052","DOI":"10.1007\/s12035-019-1627-x","volume":"56","author":"A Dolinar","year":"2019","unstructured":"Dolinar A, Koritnik B, Glavac D, Ravnik-Glavac M (2019) Circular RNAs as potential blood biomarkers in amyotrophic lateral sclerosis. Mol Neurobiol 56(12):8052\u20138062. https:\/\/doi.org\/10.1007\/s12035-019-1627-x","journal-title":"Mol Neurobiol"},{"issue":"10","key":"4605_CR12","doi-asserted-by":"publisher","first-page":"e0141214","DOI":"10.1371\/journal.pone.0141214","volume":"10","author":"S Memczak","year":"2015","unstructured":"Memczak S, Papavasileiou P, Peters O, Rajewsky N (2015) Identification and characterization of circular RNAs as a new class of putative biomarkers in human blood. PLoS One 10(10):e0141214. https:\/\/doi.org\/10.1371\/journal.pone.0141214","journal-title":"PLoS One"},{"issue":"9","key":"4605_CR13","doi-asserted-by":"publisher","first-page":"943","DOI":"10.2217\/bmm-2016-0130","volume":"10","author":"X Cui","year":"2016","unstructured":"Cui X, Niu W, Kong L, He M, Jiang K, Chen S et al (2016) hsa_circRNA_103636: potential novel diagnostic and therapeutic biomarker in Major depressive disorder. Biomark Med 10(9):943\u2013952. https:\/\/doi.org\/10.2217\/bmm-2016-0130","journal-title":"Biomark Med"},{"key":"4605_CR14","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3389\/fgene.2013.00307","volume":"4","author":"WJ Lukiw","year":"2013","unstructured":"Lukiw WJ (2013) Circular RNA (circRNA) in Alzheimer\u2019s disease (AD). Front Genet 4:307. https:\/\/doi.org\/10.3389\/fgene.2013.00307","journal-title":"Front Genet"},{"issue":"2","key":"4605_CR15","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1093\/nar\/gkz1117","volume":"48","author":"V Pagliarini","year":"2020","unstructured":"Pagliarini V, Jolly A, Bielli P, Di Rosa V, De la Grange P, Sette C (2020) Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization. Nucleic Acids Res 48(2):633\u2013645. https:\/\/doi.org\/10.1093\/nar\/gkz1117","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"4605_CR16","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.1093\/nar\/gkz034","volume":"47","author":"EW Ottesen","year":"2019","unstructured":"Ottesen EW, Luo D, Seo J, Singh NN, Singh RN (2019) Human Survival Motor Neuron genes generate a vast repertoire of circular RNAs. Nucleic Acids Res 47(6):2884\u20132905. https:\/\/doi.org\/10.1093\/nar\/gkz034","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"4605_CR17","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s13023-020-01356-1","volume":"15","author":"E Mercuri","year":"2020","unstructured":"Mercuri E, Lucibello S, Perulli M, Coratti G, de Sanctis R, Pera MC et al (2020) Longitudinal natural history of type I spinal muscular atrophy: a critical review. Orphanet J Rare Dis 15(1):84. https:\/\/doi.org\/10.1186\/s13023-020-01356-1","journal-title":"Orphanet J Rare Dis"},{"issue":"3","key":"4605_CR18","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.nmd.2009.11.014","volume":"20","author":"AM Glanzman","year":"2010","unstructured":"Glanzman AM, Mazzone E, Main M, Pelliccioni M, Wood J, Swoboda KJ et al (2010) The children\u2019s hospital of philadelphia infant test of neuromuscular disorders (CHOP INTEND): test development and reliability. Neuromuscul Disord 20(3):155\u2013161. https:\/\/doi.org\/10.1016\/j.nmd.2009.11.014","journal-title":"Neuromuscul Disord"},{"issue":"18","key":"4605_CR19","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1056\/NEJMoa1702752","volume":"377","author":"RS Finkel","year":"2017","unstructured":"Finkel RS, Mercuri E, Darras BT, Connolly AM, Kuntz NL, Kirschner J et al (2017) Nusinersen versus Sham control in infantile-onset spinal muscular atrophy. N Engl J Med 377(18):1723\u20131732. https:\/\/doi.org\/10.1056\/NEJMoa1702752","journal-title":"N Engl J Med"},{"issue":"1","key":"4605_CR20","doi-asserted-by":"publisher","first-page":"e0170628","DOI":"10.1371\/journal.pone.0170628","volume":"12","author":"I Helwa","year":"2017","unstructured":"Helwa I, Cai J, Drewry MD, Zimmerman A, Dinkins MB, Khaled ML et al (2017) A comparative study of serum exosome isolation using differential ultracentrifugation and three commercial reagents. PLoS One 12(1):e0170628. https:\/\/doi.org\/10.1371\/journal.pone.0170628","journal-title":"PLoS One"},{"issue":"16","key":"4605_CR21","doi-asserted-by":"publisher","first-page":"8755","DOI":"10.1093\/nar\/gkz576","volume":"47","author":"MS Xiao","year":"2019","unstructured":"Xiao MS, Wilusz JE (2019) An improved method for circular RNA purification using RNase R that efficiently removes linear RNAs containing G-quadruplexes or structured 3\u2019 ends. Nucleic Acids Res 47(16):8755\u20138769. https:\/\/doi.org\/10.1093\/nar\/gkz576","journal-title":"Nucleic Acids Res"},{"key":"4605_CR22","doi-asserted-by":"publisher","unstructured":"Sidhom K, Obi PO, Saleem A (2020) A review of exosomal isolation methods: is size exclusion chromatography the best option? Int J Mol Sci 21(18). https:\/\/doi.org\/10.3390\/ijms21186466","DOI":"10.3390\/ijms21186466"},{"issue":"3","key":"4605_CR23","doi-asserted-by":"publisher","first-page":"194","DOI":"10.5863\/1551-6776-24.3.194","volume":"24","author":"EE Neil","year":"2019","unstructured":"Neil EE, Bisaccia EK (2019) Nusinersen: a novel antisense oligonucleotide for the treatment of spinal muscular atrophy. J Pediatr Pharmacol Ther 24(3):194\u2013203. https:\/\/doi.org\/10.5863\/1551-6776-24.3.194","journal-title":"J Pediatr Pharmacol Ther"},{"key":"4605_CR24","doi-asserted-by":"publisher","unstructured":"Abiusi E, Infante P, Cagnoli C, Lospinoso Severini L, Pane M, Coratti G, et al. (2021) SMA-miRs (miR-181a-5p, -324\u20135p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples. Elife 10. https:\/\/doi.org\/10.7554\/eLife.68054","DOI":"10.7554\/eLife.68054"},{"key":"4605_CR25","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3390\/pharmaceutics15010170","volume":"15","author":"AM D\u2019Silva","year":"2023","unstructured":"D\u2019Silva AM, Kariyawasam D, Venkat P, Mayoh C, Farrar MA (2023) Identification of novel CSF-derived mi RNAs in treated paediatric onset spinal muscular atrophy: an exploratory study. Pharmaceutics 15:170. https:\/\/doi.org\/10.3390\/pharmaceutics15010170","journal-title":"Pharmaceutics"},{"issue":"5","key":"4605_CR26","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1002\/acn3.779","volume":"6","author":"BT Darras","year":"2019","unstructured":"Darras BT, Crawford TO, Finkel RS, Mercuri E, De Vivo DC, Oskoui M et al (2019) Neurofilament as a potential biomarker for spinal muscular atrophy. Ann Clin Transl Neurol 6(5):932\u2013944. https:\/\/doi.org\/10.1002\/acn3.779","journal-title":"Ann Clin Transl Neurol"},{"key":"4605_CR27","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.omtm.2021.10.011","volume":"23","author":"CRR Alves","year":"2021","unstructured":"Alves CRR, Petrillo M, Spellman R, Garner R, Zhang R, Kiefer M et al (2021) Implications of circulating neurofilaments for spinal muscular atrophy treatment early in life: a case series. Mol Ther Methods Clin Dev 23:524\u2013538. https:\/\/doi.org\/10.1016\/j.omtm.2021.10.011","journal-title":"Mol Ther Methods Clin Dev"},{"key":"4605_CR28","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1002\/acn3.51449","volume":"8","author":"E Nitz","year":"2021","unstructured":"Nitz E, Smitka M, Schallner J, Akg\u00fcn K, Ziemssen T, von der Hagen M et al (2021) Serum neurofilament light chain in pediatric spinal muscular atrophy patients and healthy children. Ann Clin Transl Neurol 8:2013\u20132024. https:\/\/doi.org\/10.1002\/acn3.51449","journal-title":"Ann Clin Transl Neurol"},{"key":"4605_CR29","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.ebiom.2018.07.036","volume":"34","author":"Z Zhang","year":"2018","unstructured":"Zhang Z, Yang T, Xiao J (2018) Circular RNAs: promising biomarkers for human diseases. EBioMedicine 34:267\u2013274. https:\/\/doi.org\/10.1016\/j.ebiom.2018.07.036","journal-title":"EBioMedicine"},{"key":"4605_CR30","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13578-019-0282-2","volume":"9","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Liu Y, Liu H, Tang WH (2019) Exosomes: biogenesis, biologic function and clinical potential. Cell Biosci 9:19. https:\/\/doi.org\/10.1186\/s13578-019-0282-2","journal-title":"Cell Biosci"},{"issue":"3","key":"4605_CR31","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s10571-016-0366-z","volume":"36","author":"ER Abels","year":"2016","unstructured":"Abels ER, Breakefield XO (2016) Introduction to extracellular vesicles: biogenesis, RNA cargo selection, content, release, and uptake. Cell Mol Neurobiol 36(3):301\u2013312. https:\/\/doi.org\/10.1007\/s10571-016-0366-z","journal-title":"Cell Mol Neurobiol"},{"issue":"7893","key":"4605_CR32","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/s41586-021-04234-3","volume":"601","author":"R Garcia-Martin","year":"2022","unstructured":"Garcia-Martin R, Wang G, Brandao BB, Zanotto TM, Shah S, Kumar Patel S et al (2022) MicroRNA sequence codes for small extracellular vesicle release and cellular retention. Nature 601(7893):446\u2013451. https:\/\/doi.org\/10.1038\/s41586-021-04234-3","journal-title":"Nature"},{"key":"4605_CR33","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1038\/ncomms3980","volume":"4","author":"C Villarroya-Beltri","year":"2013","unstructured":"Villarroya-Beltri C, Gutierrez-Vazquez C, Sanchez-Cabo F, Perez-Hernandez D, Vazquez J, Martin-Cofreces N et al (2013) Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat Commun 4:2980. https:\/\/doi.org\/10.1038\/ncomms3980","journal-title":"Nat Commun"},{"issue":"5","key":"4605_CR34","doi-asserted-by":"publisher","first-page":"847","DOI":"10.3233\/JND-230011","volume":"10","author":"J Sun","year":"2023","unstructured":"Sun J, Harrington MA, Porter B, TREAT-NMD Global Registry Network for SMA (2023) Sex difference in spinal muscular atrophy patients - are males more vulnerable? J Neuromuscul Dis 10(5):847\u2013867. https:\/\/doi.org\/10.3233\/JND-230011","journal-title":"J Neuromuscul Dis"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04605-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04605-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04605-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T20:16:07Z","timestamp":1743365767000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04605-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["4605"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04605-7","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]},"assertion":[{"value":"21 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Institutional Review Board (Ethics Committee prot. Number 25188\/19).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"A written informed consent was obtained from all participants or guardians of participants to the study, and they did not receive any form of economic compensation.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable: the manuscript does not contain data from any individual person.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}