{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T14:13:29Z","timestamp":1782224009599,"version":"3.54.5"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Postgraduate Research & Practice Innovation Program of Harbin Medical University","award":["YJSCX2023-101HYD"],"award-info":[{"award-number":["YJSCX2023-101HYD"]}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2022YFE0118200"],"award-info":[{"award-number":["2022YFE0118200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China postdoctoral science foundation","doi-asserted-by":"crossref","award":["2022M720521"],"award-info":[{"award-number":["2022M720521"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China postdoctoral science foundation","doi-asserted-by":"crossref","award":["2016M600261"],"award-info":[{"award-number":["2016M600261"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province of China","doi-asserted-by":"crossref","award":["YQ2022H003"],"award-info":[{"award-number":["YQ2022H003"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s12035-024-04642-2","type":"journal-article","created":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T23:28:18Z","timestamp":1734910098000},"page":"6128-6149","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Analysis of Human Brain RNA-seq Reveals the Combined Effects of Ferroptosis and Autophagy on Alzheimer\u2019s Disease in Multiple Brain Regions"],"prefix":"10.1007","volume":"62","author":[{"given":"Ke","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangliang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"issue":"9770","key":"4642_CR1","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/S0140-6736(10)61349-9","volume":"377","author":"C Ballard","year":"2011","unstructured":"Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E (2011) Alzheimer\u2019s disease. Lancet 377(9770):1019\u20131031. https:\/\/doi.org\/10.1016\/S0140-6736(10)61349-9","journal-title":"Lancet"},{"issue":"10284","key":"4642_CR2","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","volume":"397","author":"P Scheltens","year":"2021","unstructured":"Scheltens P, De Strooper B, Kivipelto M, Holstege H, Ch\u00e9telat G, Teunissen CE, Cummings J, van der Flier WM (2021) Alzheimer\u2019s disease. Lancet 397(10284):1577\u20131590. https:\/\/doi.org\/10.1016\/S0140-6736(20)32205-4","journal-title":"Lancet"},{"issue":"3","key":"4642_CR3","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/S1474-4422(20)30440-3","volume":"20","author":"J Graff-Radford","year":"2021","unstructured":"Graff-Radford J, Yong KX, Apostolova LG, Bouwman FH, Carrillo M, Dickerson BC, Rabinovici GD, Schott JM et al (2021) New insights into atypical Alzheimer\u2019s disease in the era of biomarkers. Lancet Neurol 20(3):222\u2013234. https:\/\/doi.org\/10.1016\/S1474-4422(20)30440-3","journal-title":"Lancet Neurol"},{"issue":"7937","key":"4642_CR4","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/d41586-022-03724-2","volume":"611","author":"E Dolgin","year":"2022","unstructured":"Dolgin E (2022) This is how an Alzheimer\u2019s gene ravages the brain. Nature 611(7937):649. https:\/\/doi.org\/10.1038\/d41586-022-03724-2","journal-title":"Nature"},{"issue":"2","key":"4642_CR5","doi-asserted-by":"publisher","first-page":"519","DOI":"10.3233\/JAD-140567","volume":"43","author":"D Wang","year":"2015","unstructured":"Wang D, Hui Y, Peng Y, Tang L, Jin J, He R, Li Y, Zhang S et al (2015) Overexpression of heme oxygenase 1 causes cognitive decline and affects pathways for tauopathy in mice. J Alzheimers Dis 43(2):519\u2013534. https:\/\/doi.org\/10.3233\/JAD-140567","journal-title":"J Alzheimers Dis"},{"key":"4642_CR6","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s00702-010-0438-z","volume":"117","author":"MT Heneka","year":"2010","unstructured":"Heneka MT, O\u2019Banion MK, Terwel D, Kummer MP (2010) Neuroinflammatory processes in Alzheimer\u2019s disease. J Neural Transm 117:919\u2013947. https:\/\/doi.org\/10.1007\/s00702-010-0438-z","journal-title":"J Neural Transm"},{"issue":"1","key":"4642_CR7","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1159\/000464422","volume":"24","author":"A Sanabria-Castro","year":"2017","unstructured":"Sanabria-Castro A, Alvarado-Echeverr\u00eda I, Monge-Bonilla C (2017) Molecular pathogenesis of Alzheimer\u2019s disease: an update. Ann Neurosci 24(1):46\u201354. https:\/\/doi.org\/10.1159\/000464422","journal-title":"Ann Neurosci"},{"issue":"4","key":"4642_CR8","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22(4):266\u2013282. https:\/\/doi.org\/10.1038\/s41580-020-00324-8","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"4642_CR9","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","volume":"31","author":"D Tang","year":"2020","unstructured":"Tang D, Chen X, Kang R, Kroemer G (2020) Ferroptosis: molecular mechanisms and health implications. Cell Res 31(2):107\u2013125. https:\/\/doi.org\/10.1038\/s41422-020-00441-1","journal-title":"Cell Res"},{"issue":"7","key":"4642_CR10","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/j.molcel.2023.03.005","volume":"83","author":"SJ Dixon","year":"2023","unstructured":"Dixon SJ, Pratt DA (2023) Ferroptosis: a flexible constellation of related biochemical mechanisms. Mol Cell 83(7):1030\u20131042. https:\/\/doi.org\/10.1016\/j.molcel.2023.03.005","journal-title":"Mol Cell"},{"issue":"12","key":"4642_CR11","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","volume":"82","author":"D Liang","year":"2022","unstructured":"Liang D, Minikes AM, Jiang X (2022) Ferroptosis at the intersection of lipid metabolism and cellular signaling. Mol Cell 82(12):2215\u20132227. https:\/\/doi.org\/10.1016\/j.molcel.2022.03.022","journal-title":"Mol Cell"},{"issue":"7","key":"4642_CR12","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1056\/NEJMc1303158","volume":"368","author":"AM Choi","year":"2013","unstructured":"Choi AM, Ryter SW, Levine B (2013) Autophagy in human health and disease. N Engl J Med 368(7):651\u2013662. https:\/\/doi.org\/10.1056\/NEJMc1303158","journal-title":"N Engl J Med"},{"issue":"16","key":"4642_CR13","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1056\/NEJMra2022774","volume":"383","author":"N Mizushima","year":"2020","unstructured":"Mizushima N, Levine B (2020) Autophagy in human diseases. N Engl J Med 383(16):1564\u20131576. https:\/\/doi.org\/10.1056\/NEJMra2022774","journal-title":"N Engl J Med"},{"issue":"19","key":"4642_CR14","doi-asserted-by":"publisher","first-page":"e108863","DOI":"10.15252\/embj.2021108863","volume":"40","author":"DJ Klionsky","year":"2021","unstructured":"Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K et al (2021) Autophagy in major human diseases. EMBO J 40(19):e108863. https:\/\/doi.org\/10.15252\/embj.2021108863","journal-title":"EMBO J"},{"issue":"6","key":"4642_CR15","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nrm1666","volume":"6","author":"EH Baehrecke","year":"2005","unstructured":"Baehrecke EH (2005) Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol 6(6):505\u2013510. https:\/\/doi.org\/10.1038\/nrm1666","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"4642_CR16","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.immuni.2021.01.018","volume":"54","author":"V Deretic","year":"2021","unstructured":"Deretic V (2021) Autophagy in inflammation, infection, and immunometabolism. Immunity 54(3):437\u2013453. https:\/\/doi.org\/10.1016\/j.immuni.2021.01.018","journal-title":"Immunity"},{"key":"4642_CR17","doi-asserted-by":"publisher","first-page":"107848","DOI":"10.1016\/j.pharmthera.2021.107848","volume":"225","author":"A Ajoolabady","year":"2021","unstructured":"Ajoolabady A, Wang S, Kroemer G, Penninger JM, Uversky VN, Pratico D, Henninger N, Reiter RJ et al (2021) Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics. Pharmacol Ther 225:107848. https:\/\/doi.org\/10.1016\/j.pharmthera.2021.107848","journal-title":"Pharmacol Ther"},{"issue":"4","key":"4642_CR18","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","volume":"147","author":"N Mizushima","year":"2011","unstructured":"Mizushima N, Komatsu M (2011) Autophagy: renovation of cells and tissues. Cell 147(4):728\u2013741. https:\/\/doi.org\/10.1016\/j.cell.2011.10.026","journal-title":"Cell"},{"issue":"5","key":"4642_CR19","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1038\/s41418-020-00685-9","volume":"28","author":"WD Bao","year":"2021","unstructured":"Bao WD, Pang P, Zhou XT, Hu F, Xiong W, Chen K, Wang J, Wang F et al (2021) Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer\u2019s disease. Cell Death Differ 28(5):1548\u20131562. https:\/\/doi.org\/10.1038\/s41418-020-00685-9","journal-title":"Cell Death Differ"},{"key":"4642_CR20","doi-asserted-by":"publisher","first-page":"101947","DOI":"10.1016\/j.redox.2021.101947","volume":"41","author":"MW Park","year":"2021","unstructured":"Park MW, Cha HW, Kim J, Kim JH, Yang H, Yoon S, Boonpraman N, Yi SS et al (2021) NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer\u2019s diseases. Redox Biol 41:101947. https:\/\/doi.org\/10.1016\/j.redox.2021.101947","journal-title":"Redox Biol"},{"key":"4642_CR21","doi-asserted-by":"publisher","first-page":"101494","DOI":"10.1016\/j.redox.2020.101494","volume":"32","author":"A Ashraf","year":"2020","unstructured":"Ashraf A, Jeandriens J, Parkes HG, So PW (2020) Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine\/glutamate antiporter in Alzheimer\u2019s disease: evidence of ferroptosis. Redox Biol 32:101494. https:\/\/doi.org\/10.1016\/j.redox.2020.101494","journal-title":"Redox Biol"},{"issue":"11","key":"4642_CR22","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1038\/s41380-019-0375-7","volume":"25","author":"S Ayton","year":"2020","unstructured":"Ayton S, Wang Y, Diouf I, Schneider JA, Brockman J, Morris MC, Bush AI (2020) Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology. Mol Psychiatry 25(11):2932\u20132941. https:\/\/doi.org\/10.1038\/s41380-019-0375-7","journal-title":"Mol Psychiatry"},{"issue":"32","key":"4642_CR23","doi-asserted-by":"publisher","first-page":"14164","DOI":"10.1073\/pnas.1009485107","volume":"107","author":"MM Lipinski","year":"2010","unstructured":"Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C et al (2010) Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer\u2019s disease. Proc Natl Acad Sci 107(32):14164\u201314169. https:\/\/doi.org\/10.1073\/pnas.1009485107","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"4642_CR24","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s40035-022-00305-1","volume":"11","author":"K Zeng","year":"2022","unstructured":"Zeng K, Yu X, Mahaman YAR, Wang JZ, Liu R, Li Y, Wang X (2022) Defective mitophagy and the etiopathogenesis of Alzheimer\u2019s disease. Transl Neurodegener 11(1):32. https:\/\/doi.org\/10.1186\/s40035-022-00305-1","journal-title":"Transl Neurodegener"},{"key":"4642_CR25","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s00401-014-1379-7","volume":"129","author":"A Peric","year":"2015","unstructured":"Peric A, Annaert W (2015) Early etiology of Alzheimer\u2019s disease: tipping the balance toward autophagy or endosomal dysfunction? Acta Neuropathol 129:363\u2013381. https:\/\/doi.org\/10.1007\/s00401-014-1379-7","journal-title":"Acta Neuropathol"},{"key":"4642_CR26","doi-asserted-by":"publisher","first-page":"101464","DOI":"10.1016\/j.arr.2021.101464","volume":"72","author":"Z Zhang","year":"2021","unstructured":"Zhang Z, Yang X, Song YQ, Tu J (2021) Autophagy in Alzheimer\u2019s disease pathogenesis: therapeutic potential and future perspectives. Ageing Res Rev 72:101464. https:\/\/doi.org\/10.1016\/j.arr.2021.101464","journal-title":"Ageing Res Rev"},{"issue":"10","key":"4642_CR27","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1016\/j.cell.2021.03.048","volume":"184","author":"M Bourdenx","year":"2021","unstructured":"Bourdenx M, Mart\u00edn-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, Diaz A, Storm NJ et al (2021) Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell 184(10):2696\u20132714. https:\/\/doi.org\/10.1016\/j.cell.2021.03.048","journal-title":"Cell"},{"issue":"7","key":"4642_CR28","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/s41556-023-01158-0","volume":"25","author":"I Choi","year":"2023","unstructured":"Choi I, Wang M, Yoo S, Xu P, Seegobin SP, Li X, Han X, Wang Q et al (2023) Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence. Nat Cell Biol 25(7):963\u2013974. https:\/\/doi.org\/10.1038\/s41556-023-01158-0","journal-title":"Nat Cell Biol"},{"issue":"6","key":"4642_CR29","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41593-022-01084-8","volume":"25","author":"JH Lee","year":"2022","unstructured":"Lee JH, Yang DS, Goulbourne CN, Im E, Stavrides P, Pensalfini A, Chan H, Bouchet-Marquis C et al (2022) Faulty autolysosome acidification in Alzheimer\u2019s disease mouse models induces autophagic build-up of A\u03b2 in neurons, yielding senile plaques. Nat Neurosci 25(6):688\u2013701. https:\/\/doi.org\/10.1038\/s41593-022-01084-8","journal-title":"Nat Neurosci"},{"key":"4642_CR30","doi-asserted-by":"publisher","first-page":"108178","DOI":"10.1016\/j.pharmthera.2022.108178","volume":"238","author":"A Filippone","year":"2022","unstructured":"Filippone A, Esposito E, Mannino D, Lyssenko N, Pratic\u00f2 D (2022) The contribution of altered neuronal autophagy to neurodegeneration. Pharmacol Ther 238:108178. https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108178","journal-title":"Pharmacol Ther"},{"issue":"11","key":"4642_CR31","doi-asserted-by":"publisher","first-page":"3882","DOI":"10.1080\/15548627.2021.1963630","volume":"17","author":"C Hung","year":"2021","unstructured":"Hung C, Livesey FJ (2021) Endolysosome and autophagy dysfunction in Alzheimer disease. Autophagy 17(11):3882\u20133883. https:\/\/doi.org\/10.1080\/15548627.2021.1963630","journal-title":"Autophagy"},{"issue":"2","key":"4642_CR32","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3858\/emm.2012.44.2.031","volume":"44","author":"JH Son","year":"2012","unstructured":"Son JH, Shim JH, Kim KH, Ha JY, Han JY (2012) Neuronal autophagy and neurodegenerative diseases. Exp Mol Med 44(2):89\u201398. https:\/\/doi.org\/10.3858\/emm.2012.44.2.031","journal-title":"Exp Mol Med"},{"issue":"4","key":"4642_CR33","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1038\/s41418-020-00728-1","volume":"28","author":"X Chen","year":"2021","unstructured":"Chen X, Yu C, Kang R, Kroemer G, Tang D (2021) Cellular degradation systems in ferroptosis. Cell Death Diff 28(4):1135\u20131148. https:\/\/doi.org\/10.1038\/s41418-020-00728-1","journal-title":"Cell Death Diff"},{"issue":"2","key":"4642_CR34","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1080\/15548627.2022.2084862","volume":"19","author":"L Su","year":"2023","unstructured":"Su L, Zhang J, Gomez H, Kellum JA, Peng Z (2023) Mitochondria ROS and mitophagy in acute kidney injury. Autophagy 19(2):401\u2013414. https:\/\/doi.org\/10.1080\/15548627.2022.2084862","journal-title":"Autophagy"},{"issue":"6","key":"4642_CR35","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1080\/15548627.2022.2152209","volume":"19","author":"L Yang","year":"2023","unstructured":"Yang L, Ye F, Liu J, Klionsky DJ, Tang D, Kang R (2023) Extracellular SQSTM1 exacerbates acute pancreatitis by activating autophagy-dependent ferroptosis. Autophagy 19(6):1733\u20131744. https:\/\/doi.org\/10.1080\/15548627.2022.2152209","journal-title":"Autophagy"},{"issue":"7","key":"4642_CR36","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1080\/15548627.2023.2165323","volume":"19","author":"Q Xue","year":"2023","unstructured":"Xue Q, Yan D, Chen X, Li X, Kang R, Klionsky DJ, Kroemer G, Chen X et al (2023) Copper-dependent autophagic degradation of GPX4 drives ferroptosis. Autophagy 19(7):1982\u20131996. https:\/\/doi.org\/10.1080\/15548627.2023.2165323","journal-title":"Autophagy"},{"issue":"4","key":"4642_CR37","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1080\/15548627.2020.1739447","volume":"17","author":"C Li","year":"2021","unstructured":"Li C, Zhang Y, Liu J, Kang R, Klionsky DJ, Tang D (2021) Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. Autophagy 17(4):948\u2013960. https:\/\/doi.org\/10.1080\/15548627.2020.1739447","journal-title":"Autophagy"},{"issue":"2","key":"4642_CR38","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/15548627.2017.1389823","volume":"14","author":"AC Racanelli","year":"2018","unstructured":"Racanelli AC, Kikkers SA, Choi AM, Cloonan SM (2018) Autophagy and inflammation in chronic respiratory disease. Autophagy 14(2):221\u2013232. https:\/\/doi.org\/10.1080\/15548627.2017.1389823","journal-title":"Autophagy"},{"issue":"7330","key":"4642_CR39","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature09782","volume":"469","author":"B Levine","year":"2011","unstructured":"Levine B, Mizushima N, Virgin HW (2011) Autophagy in immunity and inflammation. Nature 469(7330):323\u2013335. https:\/\/doi.org\/10.1038\/nature09782","journal-title":"Nature"},{"issue":"6046","key":"4642_CR40","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1126\/science.1201940","volume":"333","author":"DR Green","year":"2011","unstructured":"Green DR, Galluzzi L, Kroemer G (2011) Mitochondria and the autophagy\u2013inflammation\u2013cell death axis in organismal aging. Science 333(6046):1109\u20131112. https:\/\/doi.org\/10.1126\/science.1201940","journal-title":"Science"},{"issue":"1","key":"4642_CR41","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrm3028","volume":"12","author":"RJ Youle","year":"2011","unstructured":"Youle RJ, Narendra DP (2011) Mechanisms of mitophagy. Nat Rev Mol Cell Biol 12(1):9\u201314. https:\/\/doi.org\/10.1038\/nrm3028","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"4642_CR42","doi-asserted-by":"publisher","first-page":"e104705","DOI":"10.15252\/embj.2020104705","volume":"40","author":"M Onishi","year":"2021","unstructured":"Onishi M, Yamano K, Sato M, Matsuda N, Okamoto K (2021) Molecular mechanisms and physiological functions of mitophagy. EMBO J 40(3):e104705. https:\/\/doi.org\/10.15252\/embj.2020104705","journal-title":"EMBO J"},{"issue":"9","key":"4642_CR43","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/s41556-018-0176-2","volume":"20","author":"K Palikaras","year":"2018","unstructured":"Palikaras K, Lionaki E, Tavernarakis N (2018) Mechanisms of mitophagy in cellular homeostasis, physiology and pathology. Nat Cell Biol 20(9):1013\u20131022. https:\/\/doi.org\/10.1038\/s41556-018-0176-2","journal-title":"Nat Cell Biol"},{"issue":"5497","key":"4642_CR44","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","volume":"290","author":"DJ Klionsky","year":"2000","unstructured":"Klionsky DJ, Emr SD (2000) Autophagy as a regulated pathway of cellular degradation. Science 290(5497):1717\u20131721. https:\/\/doi.org\/10.1126\/science.290.5497.1717","journal-title":"Science"},{"issue":"1","key":"4642_CR45","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/cr.2013.168","volume":"24","author":"Y Feng","year":"2014","unstructured":"Feng Y, He D, Yao Z, Klionsky DJ (2014) The machinery of macroautophagy. Cell Res 24(1):24\u201341. https:\/\/doi.org\/10.1038\/cr.2013.168","journal-title":"Cell Res"},{"issue":"3","key":"4642_CR46","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/s41580-022-00529-z","volume":"24","author":"L Wang","year":"2023","unstructured":"Wang L, Klionsky DJ, Shen HM (2023) The emerging mechanisms and functions of microautophagy. Nat Rev Mol Cell Biol 24(3):186\u2013203. https:\/\/doi.org\/10.1038\/s41580-022-00529-z","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"4642_CR47","doi-asserted-by":"publisher","first-page":"295","DOI":"10.4161\/auto.4144","volume":"3","author":"JF Dice","year":"2007","unstructured":"Dice JF (2007) Chaperone-mediated autophagy. Autophagy 3(4):295\u2013299. https:\/\/doi.org\/10.4161\/auto.4144","journal-title":"Autophagy"},{"issue":"3","key":"4642_CR48","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s41580-022-00542-2","volume":"24","author":"JNS Vargas","year":"2023","unstructured":"Vargas JNS, Hamasaki M, Kawabata T, Youle RJ, Yoshimori T (2023) The mechanisms and roles of selective autophagy in mammals. Nat Rev Mol Cell Biol 24(3):167\u2013185. https:\/\/doi.org\/10.1038\/s41580-022-00542-2","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"4642_CR49","doi-asserted-by":"publisher","first-page":"2382659","DOI":"10.1080\/27694127.2024.2382659","volume":"3","author":"TY Nazarko","year":"2024","unstructured":"Nazarko TY (2024) Autophagy of glycogen is non-selective in  Komagataella phaffii . Autophagy Rep 3(1):2382659. https:\/\/doi.org\/10.1080\/27694127.2024.2382659","journal-title":"Autophagy Rep"},{"issue":"6","key":"4642_CR50","first-page":"441","volume":"1","author":"PO Seglen","year":"1990","unstructured":"Seglen PO, Gordon PB, Holen I (1990) Non-selective autophagy. Semin Cell Biol 1(6):441\u2013448","journal-title":"Non-selective autophagy. Semin Cell Biol"},{"issue":"9","key":"4642_CR51","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1016\/j.jmb.2016.02.004","volume":"428","author":"G Zaffagnini","year":"2016","unstructured":"Zaffagnini G, Martens S (2016) Mechanisms of selective autophagy. J Mol Biol 428(9):1714\u20131724. https:\/\/doi.org\/10.1016\/j.jmb.2016.02.004","journal-title":"J Mol Biol"},{"issue":"1","key":"4642_CR52","doi-asserted-by":"publisher","first-page":"zcac010","DOI":"10.1093\/narcan\/zcac010","volume":"4","author":"C Zou","year":"2022","unstructured":"Zou C, He Q, Feng Y, Chen M, Zhang D (2022) A m6Avalue predictive of prostate cancer stemness, tumor immune landscape and immunotherapy response. NAR Cancer 4(1):zcac010. https:\/\/doi.org\/10.1093\/narcan\/zcac010","journal-title":"NAR Cancer"},{"issue":"1","key":"4642_CR53","doi-asserted-by":"publisher","first-page":"180","DOI":"10.7150\/ijbs.64654","volume":"18","author":"B Tang","year":"2022","unstructured":"Tang B, Yan R, Zhu J, Cheng S, Kong C, Chen W, Fang S, Wang Y et al (2022) Integrative analysis of the molecular mechanisms, immunological features and immunotherapy response of ferroptosis regulators across 33 cancer types. Int J Biol Sci 18(1):180. https:\/\/doi.org\/10.7150\/ijbs.64654","journal-title":"Int J Biol Sci"},{"issue":"7","key":"4642_CR54","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu DI, Hu Y, Law CW, Shi W, Smyth GK (2015) limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43(7):e47\u2013e47. https:\/\/doi.org\/10.1093\/nar\/gkv007","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"4642_CR55","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B et al (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498\u20132504. https:\/\/doi.org\/10.1101\/gr.1239303","journal-title":"Genome Res"},{"issue":"3","key":"4642_CR56","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, Feng T, Zhou L et al (2021) clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. The Innovation 2(3):100141. https:\/\/doi.org\/10.1016\/j.xinn.2021.100141","journal-title":"The Innovation"},{"issue":"11","key":"4642_CR57","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1038\/s41592-023-02014-7","volume":"20","author":"AS Castanza","year":"2023","unstructured":"Castanza AS, Recla JM, Eby D, Thorvaldsd\u00f3ttir H, Bult CJ, Mesirov JP (2023) Extending support for mouse data in the Molecular Signatures Database (MSigDB). Nat Methods 20(11):1619\u20131620. https:\/\/doi.org\/10.1038\/s41592-023-02014-7","journal-title":"Nat Methods"},{"key":"4642_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinforma 9:1\u201313. https:\/\/doi.org\/10.1186\/1471-2105-9-559","journal-title":"BMC Bioinforma"},{"key":"4642_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jneuroim.2017.07.009","volume":"311","author":"M Hebron","year":"2017","unstructured":"Hebron M, Peyton M, Liu X, Gao X, Wang R, Lonskaya I, Moussa CEH (2017) Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models. J Neuroimmunol 311:1\u20139. https:\/\/doi.org\/10.1016\/j.jneuroim.2017.07.009","journal-title":"J Neuroimmunol"},{"issue":"1","key":"4642_CR60","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s10571-024-01453-w","volume":"44","author":"W Yu","year":"2024","unstructured":"Yu W, Li Y, Zhong F, Deng Z, Wu J, Yu W, L\u00fc Y (2024) Disease-associated neurotoxic astrocyte markers in Alzheimer disease based on integrative single-nucleus RNA sequencing. Cell Mol Neurobiol 44(1):20. https:\/\/doi.org\/10.1007\/s10571-024-01453-w","journal-title":"Cell Mol Neurobiol"},{"key":"4642_CR61","doi-asserted-by":"publisher","first-page":"736008","DOI":"10.3389\/fncel.2021.736008","volume":"15","author":"Y Yang","year":"2021","unstructured":"Yang Y, Zhou X, Liu X, Song R, Gao Y, Wang S (2021) Implications of FBXW7 in neurodevelopment and neurodegeneration: molecular mechanisms and therapeutic potential. Front Cell Neurosci 15:736008. https:\/\/doi.org\/10.3389\/fncel.2021.736008","journal-title":"Front Cell Neurosci"},{"key":"4642_CR62","doi-asserted-by":"publisher","first-page":"825729","DOI":"10.3389\/fcell.2021.825729","volume":"9","author":"H Song","year":"2022","unstructured":"Song H, Yang J, Yu W (2022) Promoter hypomethylation of TGFBR3 as a risk factor of Alzheimer\u2019s disease: an integrated epigenomic-transcriptomic analysis. Front Cell Dev Biol 9:825729. https:\/\/doi.org\/10.3389\/fcell.2021.825729","journal-title":"Front Cell Dev Biol"},{"issue":"12","key":"4642_CR63","doi-asserted-by":"publisher","first-page":"eadk9884","DOI":"10.1126\/sciadv.adk9884","volume":"10","author":"F Yang","year":"2024","unstructured":"Yang F, Beltran-Lobo P, Sung K, Goldrick C, Croft CL, Nishimura A, Hedges E, Mahiddine F et al (2024) Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection. Sci Adv 10(12):eadk9884. https:\/\/doi.org\/10.1126\/sciadv.adk9884","journal-title":"Sci Adv"},{"key":"4642_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-018-0254-8","volume":"13","author":"S Rangaraju","year":"2018","unstructured":"Rangaraju S, Dammer EB, Raza SA, Rathakrishnan P, Xiao H, Gao T, Duong DM, Pennington MW et al (2018) Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer\u2019s disease. Mol Neurodegener 13:1\u201325. https:\/\/doi.org\/10.1186\/s13024-018-0254-8","journal-title":"Mol Neurodegener"},{"issue":"1","key":"4642_CR65","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s13024-023-00657-w","volume":"18","author":"I Pes\u00e4maa","year":"2023","unstructured":"Pes\u00e4maa I, M\u00fcller SA, Robinson S, Darcher A, Paquet D, Zetterberg H, Lichtenthaler SF, Haass C (2023) A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer\u2019s disease patients from controls. Mol Neurodegener 18(1):70. https:\/\/doi.org\/10.1186\/s13024-023-00657-w","journal-title":"Mol Neurodegener"},{"issue":"3","key":"4642_CR66","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3390\/biology10030184","volume":"10","author":"JY Lee","year":"2021","unstructured":"Lee JY, Kim WK, Bae KH, Lee SC, Lee EW (2021) Lipid metabolism and ferroptosis. Biology 10(3):184. https:\/\/doi.org\/10.3390\/biology10030184","journal-title":"Biology"},{"issue":"1","key":"4642_CR67","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41398-023-02695-w","volume":"13","author":"Y Sun","year":"2023","unstructured":"Sun Y, Zhu J, Yang Y, Zhang Z, Zhong H, Zeng G, Zhou D, Nowakowski RS et al (2023) Identification of candidate DNA methylation biomarkers related to Alzheimer\u2019s disease risk by integrating genome and blood methylome data. Transl Psychiatry 13(1):387. https:\/\/doi.org\/10.1038\/s41398-023-02695-w","journal-title":"Transl Psychiatry"},{"issue":"6248","key":"4642_CR68","doi-asserted-by":"publisher","first-page":"1255555","DOI":"10.1126\/science.1255555","volume":"349","author":"M Goedert","year":"2015","unstructured":"Goedert M (2015) Alzheimer\u2019s and Parkinson\u2019s diseases: the prion concept in relation to assembled A\u03b2, tau, and \u03b1-synuclein. Science 349(6248):1255555. https:\/\/doi.org\/10.1126\/science.1255555","journal-title":"Science"},{"key":"4642_CR69","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1038\/s41418-020-0542-z","volume":"10","author":"PR Angelova","year":"2020","unstructured":"Angelova PR, Choi ML, Berezhnov AV, Horrocks MH, Hughes CD, De S, Rodrigues M, Yapom R, Little D et al (2020) Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. Cell Death Differ 10:2781\u201396. https:\/\/doi.org\/10.1038\/s41418-020-0542-z","journal-title":"Cell Death Differ"},{"key":"4642_CR70","doi-asserted-by":"publisher","unstructured":"Kulkarni PG, Mohire VM, Waghmare PP, Banerjee T (2024) Interplay of mitochondria associated membrane proteins and autophagy: implications in neurodegeneration. Mitochondrion 101874. https:\/\/doi.org\/10.1016\/j.mito.2024.101874","DOI":"10.1016\/j.mito.2024.101874"},{"key":"4642_CR71","doi-asserted-by":"publisher","first-page":"118145","DOI":"10.1016\/j.jep.2024.118145","volume":"329","author":"X Shan","year":"2024","unstructured":"Shan X, Tao W, Li J, Tao W, Li D, Zhou L, Yang X, Dong C et al (2024) Kai-Xin-San ameliorates Alzheimer\u2019s disease-related neuropathology and cognitive impairment in APP\/PS1 mice via the mitochondrial autophagy-NLRP3 inflammasome pathway. J Ethnopharmacol 329:118145. https:\/\/doi.org\/10.1016\/j.jep.2024.118145","journal-title":"J Ethnopharmacol"},{"key":"4642_CR72","doi-asserted-by":"publisher","first-page":"4310","DOI":"10.1039\/d4fo00520a","volume":"8","author":"Y Xie","year":"2024","unstructured":"Xie Y, Ke X, Ye Z, Li X, Chen Z, Liu J, Wu Z, Liu Q et al (2024) Se-methylselenocysteine ameliorates mitochondrial function by targeting both mitophagy and autophagy in the mouse model of Alzheimer\u2019s disease. Food Funct 8:4310\u201322. https:\/\/doi.org\/10.1039\/d4fo00520a","journal-title":"Food Funct"},{"issue":"5","key":"4642_CR73","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.neuron.2019.06.010","volume":"103","author":"A Griciuc","year":"2019","unstructured":"Griciuc A, Patel S, Federico AN, Choi SH, Innes BJ, Oram MK, Cereghetti G, McGinty D et al (2019) TREM2 acts downstream of CD33 in modulating microglial pathology in Alzheimer\u2019s disease. Neuron 103(5):820\u201335. https:\/\/doi.org\/10.1016\/j.neuron.2019.06.010","journal-title":"Neuron"},{"issue":"1","key":"4642_CR74","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.bbrc.2017.11.080","volume":"495","author":"F Tang","year":"2018","unstructured":"Tang F, Pacheco MTF, Chen P, Liang D, Li W (2018) Secretogranin III promotes angiogenesis through MEK\/ERK signaling pathway. Biochem Biophys Res Commun 495(1):781\u2013786. https:\/\/doi.org\/10.1016\/j.bbrc.2017.11.080","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"4642_CR75","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1677\/JOE-08-0531","volume":"202","author":"K Hotta","year":"2009","unstructured":"Hotta K, Hosaka M, Tanabe A, Takeuchi T (2009) Secretogranin II binds to secretogranin III and forms secretory granules with orexin, neuropeptide Y, and POMC. J Endocrinol 202(1):111. https:\/\/doi.org\/10.1677\/JOE-08-0531","journal-title":"J Endocrinol"},{"key":"4642_CR76","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.3389\/fphys.2019.0132","volume":"10","author":"AK Mandal","year":"2019","unstructured":"Mandal AK, Mount DB (2019) Interaction between ITM2B and GLUT9 links urate transport to neurodegenerative disorders. Front Physiol 10:1323. https:\/\/doi.org\/10.3389\/fphys.2019.0132","journal-title":"Front Physiol"},{"issue":"1","key":"4642_CR77","doi-asserted-by":"publisher","first-page":"7173","DOI":"10.1038\/s41467-021-27198-4","volume":"12","author":"A Tin","year":"2021","unstructured":"Tin A, Schlosser P, Matias-Garcia PR, Thio CH, Joehanes R, Liu H, Yu Z, Weihs A et al (2021) Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus. Nat Comm 12(1):7173. https:\/\/doi.org\/10.1038\/s41467-021-27198-4","journal-title":"Nat Comm"},{"issue":"3","key":"4642_CR78","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/s10495-023-01909-2","volume":"29","author":"W Zhang","year":"2024","unstructured":"Zhang W, Li Q, Zhang Y, Wang Z, Yuan S, Zhang X, Zhao M, Zhuang W et al (2024) Multiple myeloma with high expression of SLC7A11 is sensitive to erastin-induced ferroptosis. Apoptosis 29(3):412\u201323. https:\/\/doi.org\/10.1007\/s10495-023-01909-2","journal-title":"Apoptosis"},{"issue":"02","key":"4642_CR79","doi-asserted-by":"publisher","first-page":"177","DOI":"10.12114\/j.issn.1007-9572.2023.0326","volume":"27","author":"Y Fan","year":"2024","unstructured":"Fan Y, Dou R, Hu J, Hou Z, Zhou C (2024) Modulation of iron death by poric acid through Nrf2\/SLC7A11\/GPX4 signal pathway in the improvement of cognitive impairment of Alzheimer\u2019s disease rats. Chin Gen Pract 27(02):177. https:\/\/doi.org\/10.12114\/j.issn.1007-9572.2023.0326","journal-title":"Chin Gen Pract"},{"issue":"5","key":"4642_CR80","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1002\/ptr.8152","volume":"38","author":"Y Gong","year":"2024","unstructured":"Gong Y, Wang Y, Li Y, Weng F, Chen T, He L (2024) Curculigoside, a traditional Chinese medicine monomer, ameliorates oxidative stress in Alzheimer\u2019s disease mouse model via suppressing ferroptosis. Phytotherapy Res 38(5):2462\u20132481. https:\/\/doi.org\/10.1002\/ptr.8152","journal-title":"Phytotherapy Res"},{"issue":"1","key":"4642_CR81","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/s40001-024-01730-w","volume":"29","author":"L Wang","year":"2024","unstructured":"Wang L, Qu F, Yu X, Yang S, Zhao B, Chen Y, Li P, Zhang Z et al (2024) Cortical lipid metabolic pathway alteration of early Alzheimer\u2019s disease and candidate drugs screen. European J Med Res 29(1):199. https:\/\/doi.org\/10.1186\/s40001-024-01730-w","journal-title":"European J Med Res"},{"issue":"19","key":"4642_CR82","doi-asserted-by":"publisher","first-page":"10389","DOI":"10.18632\/aging.205084","volume":"15","author":"D Hu","year":"2023","unstructured":"Hu D, Mo X, Jihang L, Huang C, Xie H, Jin L (2023) Novel diagnostic biomarkers of oxidative stress, immunological characterization and experimental validation in Alzheimer\u2019s disease. Aging (Albany NY) 15(19):10389. https:\/\/doi.org\/10.18632\/aging.205084","journal-title":"Aging (Albany NY)"},{"issue":"3","key":"4642_CR83","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1152\/jn.00172.2022","volume":"129","author":"DR Ladle","year":"2023","unstructured":"Ladle DR, Hippenmeyer S (2023) Loss of ETV1\/ER81 in motor neurons leads to reduced monosynaptic inputs from proprioceptive sensory neurons. J Neurophysiol 129(3):501\u2013512. https:\/\/doi.org\/10.1152\/jn.00172.2022","journal-title":"J Neurophysiol"},{"key":"4642_CR84","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1002\/alz.12254","volume":"6","author":"HD Li","year":"2021","unstructured":"Li HD, Funk CC, McFarland K, Dammer EB, Allen M, Carrasquillo MM, Levites Y, Chakrabarty P et al (2021) Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer\u2019s disease. Alzheimer\u2019s Dementia 6:984\u20131004. https:\/\/doi.org\/10.1002\/alz.12254","journal-title":"Alzheimer's Dementia"},{"key":"4642_CR85","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neuint.2013.10.013","volume":"64","author":"MG Tan","year":"2014","unstructured":"Tan MG, Lee C, Lee JH, Francis PT, Williams RJ, Ram\u00edrez MJ, Chen CP, Wong PT et al (2014) Decreased rabphilin 3A immunoreactivity in Alzheimer\u2019s disease is associated with A\u03b2 burden. Neurochem Int 64:29\u201336. https:\/\/doi.org\/10.1016\/j.neuint.2013.10.013","journal-title":"Neurochem Int"},{"issue":"5","key":"4642_CR86","doi-asserted-by":"publisher","first-page":"e20201290","DOI":"10.1084\/jem.20201290","volume":"218","author":"MS Woo","year":"2021","unstructured":"Woo MS, Ufer F, Rothammer N, Di Liberto G, Binkle L, Haferkamp U, Sonner JK, Engler JB et al (2021) Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation. J Exp Med 218(5):e20201290. https:\/\/doi.org\/10.1084\/jem.20201290","journal-title":"J Exp Med"},{"key":"4642_CR87","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s00213-015-4131-7","volume":"233","author":"JH Lee","year":"2016","unstructured":"Lee JH, Koh SQ, Guadagna S, Francis PT, Esiri MM, Chen CP, Wong PT-H, Dawe GS, Lai MK (2016) Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer\u2019s disease patients. Psychopharmacology 233:591\u2013598. https:\/\/doi.org\/10.1007\/s00213-015-4131-7","journal-title":"Psychopharmacology"},{"key":"4642_CR88","doi-asserted-by":"publisher","first-page":"1001546","DOI":"10.3389\/fncom.2022.1001546","volume":"16","author":"H Sun","year":"2022","unstructured":"Sun H, Yang J, Li X, Lyu Y, Xu Z, He H, Tong X, Ji T et al (2022) Identification of feature genes and pathways for Alzheimer\u2019s disease via WGCNA and LASSO regression. Front Comp Neurosci 16:1001546. https:\/\/doi.org\/10.3389\/fncom.2022.1001546","journal-title":"Front Comp Neurosci"},{"key":"4642_CR89","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s00702-017-1796-6","volume":"125","author":"CJ Scholz","year":"2018","unstructured":"Scholz CJ, Weber H, Jungwirth S, Danielczyk W, Reif A, Tragl KH, Fischer P, Riederer P et al (2018) Explorative results from multistep screening for potential genetic risk loci of Alzheimer\u2019s disease in the longitudinal VITA study cohort. J Neural Transm. 125:77\u201387. https:\/\/doi.org\/10.1007\/s00702-017-1796-6","journal-title":"J Neural Transm."},{"key":"4642_CR90","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3389\/fnagi.2019.00101","volume":"11","author":"G Meng","year":"2019","unstructured":"Meng G, Mei H (2019) Transcriptional dysregulation study reveals a core network involving the progression of Alzheimer\u2019s disease. Front Aging Neurosci 11:101. https:\/\/doi.org\/10.3389\/fnagi.2019.00101","journal-title":"Front Aging Neurosci"},{"key":"4642_CR91","doi-asserted-by":"publisher","unstructured":"Huang C, Luo J, Wen X, Li K (2022) Linking diabetes mellitus with Alzheimer\u2019s disease: bioinformatics analysis for the potential pathways and characteristic genes. Biochem Gen 1\u201327. https:\/\/doi.org\/10.1007\/s10528-021-10154-8","DOI":"10.1007\/s10528-021-10154-8"},{"key":"4642_CR92","doi-asserted-by":"publisher","first-page":"602781","DOI":"10.3389\/fnagi.2021.602781","volume":"13","author":"W Yu","year":"2021","unstructured":"Yu W, Yu W, Yang Y, L\u00fc Y (2021) Exploring the key genes and identification of potential diagnosis biomarkers in Alzheimer\u2019s disease using bioinformatics analysis. Front Aging Neurosci 13:602781. https:\/\/doi.org\/10.3389\/fnagi.2021.602781","journal-title":"Front Aging Neurosci"},{"issue":"4","key":"4642_CR93","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.bbrc.2011.09.136","volume":"414","author":"HY Sung","year":"2011","unstructured":"Sung HY, Choi EN, Jo SA, Oh S, Ahn JH (2011) Amyloid protein-mediated differential DNA methylation status regulates gene expression in Alzheimer\u2019s disease model cell line. Biochem Biophys Res Commun 414(4):700\u2013705. https:\/\/doi.org\/10.1016\/j.bbrc.2011.09.136","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04642-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04642-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04642-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:08:54Z","timestamp":1743379734000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04642-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":93,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["4642"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04642-2","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,23]]},"assertion":[{"value":"11 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}