{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:04:27Z","timestamp":1785539067234,"version":"3.56.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1007\/s12035-025-04786-9","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T14:38:16Z","timestamp":1740407896000},"page":"8261-8278","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Caloric Restriction Attenuated Nerve Damages Mediated Through SIRT-1\u2014a Study Using Nerve Crush Injury Model in Rats"],"prefix":"10.1007","volume":"62","author":[{"given":"Meei-Ling","family":"Sheu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Yi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu-Yen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Ju","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Sheehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weir-Chiang","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Chuan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"4786_CR1","doi-asserted-by":"publisher","first-page":"698256","DOI":"10.1155\/2014\/698256","volume":"2014","author":"D Grinsell","year":"2014","unstructured":"Grinsell D, Keating CP (2014) Peripheral nerve reconstruction after injury: a review of clinical and experimental therapies. BioMed Res Int 2014:698256. https:\/\/doi.org\/10.1155\/2014\/698256","journal-title":"BioMed Res Int"},{"issue":"1","key":"4786_CR2","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1097\/00005373-199807000-00025","volume":"45","author":"J Noble","year":"1998","unstructured":"Noble J, Munro CA, Prasad VS, Midha R (1998) Analysis of upper and lower extremity peripheral nerve injuries in a population of patients with multiple injuries. Journal of Trauma 45(1):116\u201322. https:\/\/doi.org\/10.1097\/00005373-199807000-00025","journal-title":"Journal of Trauma"},{"issue":"1","key":"4786_CR3","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jhsb.2004.09.003","volume":"30","author":"HE Rosberg","year":"2005","unstructured":"Rosberg HE, Carlsson KS, H\u00f6jg\u00e5rd S, Lindgren B, Lundborg G, Dahlin LB (2005) Injury to the human median and ulnar nerves in the forearm\u2013analysis of costs for treatment and rehabilitation of 69 patients in southern Sweden. Journal of Hand Surgery (Edinburgh, Scotland) 30(1):35\u20139. https:\/\/doi.org\/10.1016\/j.jhsb.2004.09.003","journal-title":"Journal of Hand Surgery (Edinburgh, Scotland)"},{"issue":"4","key":"4786_CR4","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.pneurobio.2007.06.005","volume":"82","author":"X Navarro","year":"2007","unstructured":"Navarro X, Viv\u00f3 M, Valero-Cabr\u00e9 A (2007) Neural plasticity after peripheral nerve injury and regeneration. Prog Neurobiol 82(4):163\u2013201. https:\/\/doi.org\/10.1016\/j.pneurobio.2007.06.005","journal-title":"Prog Neurobiol"},{"issue":"3","key":"4786_CR5","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1097\/prs.0000000000004121","volume":"141","author":"CA Kubiak","year":"2018","unstructured":"Kubiak CA, Kung TA, Brown DL, Cederna PS, Kemp SWP (2018) State-of-the-art techniques in treating peripheral nerve injury. Plast Reconstr Surg 141(3):702\u201310. https:\/\/doi.org\/10.1097\/prs.0000000000004121","journal-title":"Plast Reconstr Surg"},{"key":"4786_CR6","doi-asserted-by":"publisher","unstructured":"Sullivan R, Dailey T, Duncan K, Abel N, Borlongan CV (2016) Peripheral nerve injury: stem cell therapy and peripheral nerve transfer. Int J Mol Sci 17(12).\u00a0https:\/\/doi.org\/10.3390\/ijms17122101","DOI":"10.3390\/ijms17122101"},{"issue":"4","key":"4786_CR7","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nrm1616","volume":"6","author":"L Bordone","year":"2005","unstructured":"Bordone L, Guarente L (2005) Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol 6(4):298\u2013305. https:\/\/doi.org\/10.1038\/nrm1616","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"4786_CR8","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/nrm3293","volume":"13","author":"RH Houtkooper","year":"2012","unstructured":"Houtkooper RH, Pirinen E, Auwerx J (2012) Sirtuins as regulators of metabolism and healthspan. Nature Rev Molecular Cell Biol 13(4):225\u201338. https:\/\/doi.org\/10.1038\/nrm3293","journal-title":"Nature Rev Molecular Cell Biol"},{"issue":"3","key":"4786_CR9","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.pneurobio.2011.09.001","volume":"95","author":"F Zhang","year":"2011","unstructured":"Zhang F, Wang S, Gan L, Vosler PS, Gao Y, Zigmond MJ et al (2011) Protective effects and mechanisms of sirtuins in the nervous system. Prog Neurobiol 95(3):373\u201395. https:\/\/doi.org\/10.1016\/j.pneurobio.2011.09.001","journal-title":"Prog Neurobiol"},{"issue":"6","key":"4786_CR10","doi-asserted-by":"publisher","first-page":"e100938","DOI":"10.1371\/journal.pone.0100938","volume":"9","author":"H Shao","year":"2014","unstructured":"Shao H, Xue Q, Zhang F, Luo Y, Zhu H, Zhang X et al (2014) Spinal SIRT1 activation attenuates neuropathic pain in mice. PloS One. 9(6):e100938. https:\/\/doi.org\/10.1371\/journal.pone.0100938","journal-title":"PloS One"},{"key":"4786_CR11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.expneurol.2013.11.013","volume":"251","author":"A Calliari","year":"2014","unstructured":"Calliari A, Bobba N, Escande C, Chini EN (2014) Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner. Experimental neurology 251:91\u2013100. https:\/\/doi.org\/10.1016\/j.expneurol.2013.11.013","journal-title":"Experimental neurology"},{"issue":"7","key":"4786_CR12","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1101\/gad.257394.114","volume":"29","author":"FM Kouri","year":"2015","unstructured":"Kouri FM, Hurley LA, Daniel WL, Day ES, Hua Y, Hao L et al (2015) miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma. Genes Dev 29(7):732\u201345. https:\/\/doi.org\/10.1101\/gad.257394.114","journal-title":"Genes Dev"},{"issue":"3","key":"4786_CR13","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1007\/s12035-013-8437-3","volume":"48","author":"XH Li","year":"2013","unstructured":"Li XH, Chen C, Tu Y, Sun HT, Zhao ML, Cheng SX et al (2013) Sirt1 promotes axonogenesis by deacetylation of Akt and inactivation of GSK3. Mol Neurobiol 48(3):490\u20139. https:\/\/doi.org\/10.1007\/s12035-013-8437-3","journal-title":"Mol Neurobiol"},{"key":"4786_CR14","doi-asserted-by":"publisher","unstructured":"McMillen BD, Aponte MM, Liu Z, Helenowski IB, Scholtens DM, Buttin BM et al (2012) Expression analysis of MIR182 and its associated target genes in advanced ovarian carcinoma. Mod Pathol: Off J U S Can Acad Pathol Inc 25(12):1644\u201353.\u00a0https:\/\/doi.org\/10.1038\/modpathol.2012.118","DOI":"10.1038\/modpathol.2012.118"},{"key":"4786_CR15","doi-asserted-by":"publisher","unstructured":"Romeo-Guitart D, Leiva-Rodriguez T, For\u00e9s J, Casas C (2019) Improved Motor Nerve Regeneration by SIRT1\/Hif1a-Mediated Autophagy. Cells 8(11).\u00a0https:\/\/doi.org\/10.3390\/cells8111354","DOI":"10.3390\/cells8111354"},{"issue":"13","key":"4786_CR16","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.1016\/j.febslet.2010.04.063","volume":"584","author":"T Sugino","year":"2010","unstructured":"Sugino T, Maruyama M, Tanno M, Kuno A, Houkin K, Horio Y (2010) Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells. FEBS Lett 584(13):2821\u20136. https:\/\/doi.org\/10.1016\/j.febslet.2010.04.063","journal-title":"FEBS Lett"},{"issue":"7","key":"4786_CR17","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.2337\/db15-1283","volume":"65","author":"Y Wang","year":"2016","unstructured":"Wang Y, Zhao X, Wu X, Dai Y, Chen P, Xie L (2016) microRNA-182 mediates Sirt1-induced diabetic corneal nerve regeneration. Diabet 65(7):2020\u201331. https:\/\/doi.org\/10.2337\/db15-1283","journal-title":"Diabet"},{"issue":"2","key":"4786_CR18","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.cmet.2008.06.012","volume":"8","author":"MD Piper","year":"2008","unstructured":"Piper MD, Bartke A (2008) Diet and aging. Cell Metab 8(2):99\u2013104. https:\/\/doi.org\/10.1016\/j.cmet.2008.06.012","journal-title":"Cell Metab"},{"issue":"3","key":"4786_CR19","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1210\/jc.2006-2184","volume":"92","author":"LM Redman","year":"2007","unstructured":"Redman LM, Heilbronn LK, Martin CK, Alfonso A, Smith SR, Ravussin E (2007) Effect of calorie restriction with or without exercise on body composition and fat distribution. J Clin Endocrinol Metab 92(3):865\u201372. https:\/\/doi.org\/10.1210\/jc.2006-2184","journal-title":"J Clin Endocrinol Metab"},{"issue":"5682","key":"4786_CR20","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1126\/science.1099196","volume":"305","author":"HY Cohen","year":"2004","unstructured":"Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B et al (2004) Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (New York, NY). 305(5682):390\u20132. https:\/\/doi.org\/10.1126\/science.1099196","journal-title":"Science (New York, NY)"},{"issue":"8","key":"4786_CR21","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.ejheart.2007.03.007","volume":"9","author":"L Liu","year":"2007","unstructured":"Liu L, Zhang X, Qian B, Min X, Gao X, Li C et al (2007) Over-expression of heat shock protein 27 attenuates doxorubicin-induced cardiac dysfunction in mice. Eur J Heart Fail 9(8):762\u20139. https:\/\/doi.org\/10.1016\/j.ejheart.2007.03.007","journal-title":"Eur J Heart Fail"},{"key":"4786_CR22","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.arr.2016.12.005","volume":"39","author":"P Kapahi","year":"2017","unstructured":"Kapahi P, Kaeberlein M, Hansen M (2017) Dietary restriction and lifespan: Lessons from invertebrate models. Ageing Res Rev 39:3\u201314. https:\/\/doi.org\/10.1016\/j.arr.2016.12.005","journal-title":"Ageing Res Rev"},{"issue":"5","key":"4786_CR23","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1186\/1479-7364-5-5-485","volume":"5","author":"A Vassilopoulos","year":"2011","unstructured":"Vassilopoulos A, Fritz KS, Petersen DR, Gius D (2011) The human sirtuin family: evolutionary divergences and functions. Human Genomics 5(5):485\u201396. https:\/\/doi.org\/10.1186\/1479-7364-5-5-485","journal-title":"Human Genomics"},{"issue":"6","key":"4786_CR24","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.tice.2014.09.002","volume":"46","author":"MG Amer","year":"2014","unstructured":"Amer MG, Mazen NF, Mohamed NM (2014) Role of calorie restriction in alleviation of age-related morphological and biochemical changes in sciatic nerve. Tissue Cell 46(6):497\u2013504. https:\/\/doi.org\/10.1016\/j.tice.2014.09.002","journal-title":"Tissue Cell"},{"issue":"12","key":"4786_CR25","doi-asserted-by":"publisher","first-page":"e0208596","DOI":"10.1371\/journal.pone.0208596","volume":"13","author":"R Coccurello","year":"2018","unstructured":"Coccurello R, Nazio F, Rossi C, De Angelis F, Vacca V, Giacovazzo G et al (2018) Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice. PloS one 13(12):e0208596. https:\/\/doi.org\/10.1371\/journal.pone.0208596","journal-title":"PloS one"},{"issue":"1","key":"4786_CR26","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1089\/rej.2009.0892","volume":"13","author":"K Opalach","year":"2010","unstructured":"Opalach K, Rangaraju S, Madorsky I, Leeuwenburgh C, Notterpek L (2010) Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves. Rejuvenation Res 13(1):65\u201374. https:\/\/doi.org\/10.1089\/rej.2009.0892","journal-title":"Rejuvenation Res"},{"key":"4786_CR27","doi-asserted-by":"publisher","unstructured":"Sheu ML, Pan LY, Sheehan J, Yang MY, Pan HC (2022) Modulation of aryl hydrocarbon receptor expression alleviated neuropathic pain in a chronic constriction nerve injury animal model. Int J Mol Sci 23(19).\u00a0https:\/\/doi.org\/10.3390\/ijms231911255","DOI":"10.3390\/ijms231911255"},{"issue":"11","key":"4786_CR28","doi-asserted-by":"publisher","first-page":"e49761","DOI":"10.1371\/journal.pone.0049761","volume":"7","author":"M Gertz","year":"2012","unstructured":"Gertz M, Nguyen GT, Fischer F, Suenkel B, Schlicker C, Fr\u00e4nzel B et al (2012) A molecular mechanism for direct sirtuin activation by resveratrol. PLoS One 7(11):e49761. https:\/\/doi.org\/10.1371\/journal.pone.0049761","journal-title":"PLoS One"},{"issue":"7170","key":"4786_CR29","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/nature06261","volume":"450","author":"JC Milne","year":"2007","unstructured":"Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ et al (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nat 450(7170):712\u20136. https:\/\/doi.org\/10.1038\/nature06261","journal-title":"Nat"},{"issue":"5","key":"4786_CR30","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.cmet.2008.08.017","volume":"8","author":"JN Feige","year":"2008","unstructured":"Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC et al (2008) Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab 8(5):347\u201358. https:\/\/doi.org\/10.1016\/j.cmet.2008.08.017","journal-title":"Cell Metab"},{"key":"4786_CR31","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/srep00070","volume":"1","author":"RK Minor","year":"2011","unstructured":"Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM et al (2011) SRT1720 improves survival and healthspan of obese mice. Sci Rep. 1:70. https:\/\/doi.org\/10.1038\/srep00070","journal-title":"Sci Rep"},{"issue":"3","key":"4786_CR32","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1093\/neuros\/nyw090","volume":"80","author":"CC Kuo","year":"2017","unstructured":"Kuo CC, Su HL, Chang TL, Chiang CY, Sheu ML, Cheng FC et al (2017) Prevention of axonal degeneration by perineurium injection of mitochondria in a sciatic nerve crush injury model. Neurosurg 80(3):475\u201388. https:\/\/doi.org\/10.1093\/neuros\/nyw090","journal-title":"Neurosurg"},{"key":"4786_CR33","doi-asserted-by":"publisher","unstructured":"Xia DY, Yuan JL, Jiang XC, Qi M, Lai NS, Wu LY et al (2021) SIRT1 Promotes M2 Microglia Polarization via Reducing ROS-Mediated NLRP3 Inflammasome Signaling After Subarachnoid Hemorrhage. Frontiers Immunol 12. https:\/\/doi.org\/10.3389\/fimmu.2021.770744","DOI":"10.3389\/fimmu.2021.770744"},{"issue":"1","key":"4786_CR34","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.1093\/neuros\/nyab105","volume":"89","author":"ML Sheu","year":"2021","unstructured":"Sheu ML, Shen CC, Tsou HK, Yang MY, Su HL, Sheehan J et al (2021) Dual regeneration of muscle and nerve by intramuscular infusion of mitochondria in a nerve crush injury model. Neurosurg 89(1):e49\u2013e59. https:\/\/doi.org\/10.1093\/neuros\/nyab105","journal-title":"Neurosurg"},{"issue":"8","key":"4786_CR35","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.tcb.2014.04.002","volume":"24","author":"S Imai","year":"2014","unstructured":"Imai S, Guarente L (2014) NAD+ and sirtuins in aging and disease. Trends Cell Biol 24(8):464\u201371. https:\/\/doi.org\/10.1016\/j.tcb.2014.04.002","journal-title":"Trends Cell Biol"},{"issue":"7","key":"4786_CR36","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.tem.2009.03.008","volume":"20","author":"C Cant\u00f3","year":"2009","unstructured":"Cant\u00f3 C, Auwerx J (2009) Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab 20(7):325\u201331. https:\/\/doi.org\/10.1016\/j.tem.2009.03.008","journal-title":"Trends Endocrinol Metab"},{"key":"4786_CR37","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1101\/sqb.2011.76.010629","volume":"76","author":"L Guarente","year":"2011","unstructured":"Guarente L (2011) Sirtuins, aging, and metabolism. Cold Spring Harb Symp Quant Biol 76:81\u201390. https:\/\/doi.org\/10.1101\/sqb.2011.76.010629","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"4786_CR38","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1146\/annurev.pathol.4.110807.092250","volume":"5","author":"MC Haigis","year":"2010","unstructured":"Haigis MC, Sinclair DA (2010) Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 5:253\u201395. https:\/\/doi.org\/10.1146\/annurev.pathol.4.110807.092250","journal-title":"Annu Rev Pathol"},{"issue":"4","key":"4786_CR39","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nrm3311","volume":"13","author":"DG Hardie","year":"2012","unstructured":"Hardie DG, Ross FA, Hawley SA (2012) AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 13(4):251\u201362. https:\/\/doi.org\/10.1038\/nrm3311","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"14","key":"4786_CR40","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1002\/glia.20761","volume":"56","author":"KR Jessen","year":"2008","unstructured":"Jessen KR, Mirsky R (2008) Negative regulation of myelination: relevance for development, injury, and demyelinating disease. Glia 56(14):1552\u201365. https:\/\/doi.org\/10.1002\/glia.20761","journal-title":"Glia"},{"issue":"6","key":"4786_CR41","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1523\/jneurosci.4537-10.2011","volume":"31","author":"J Jung","year":"2011","unstructured":"Jung J, Cai W, Lee HK, Pellegatta M, Shin YK, Jang SY et al (2011) Actin polymerization is essential for myelin sheath fragmentation during Wallerian degeneration. The Journal of Neurosci 31(6):2009\u201315. https:\/\/doi.org\/10.1523\/jneurosci.4537-10.2011","journal-title":"The Journal of Neurosci"},{"issue":"3","key":"4786_CR42","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/jnc.13587","volume":"137","author":"J Yu","year":"2016","unstructured":"Yu J, Wu Y, Yang P (2016) High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects. J Neurochem 137(3):371\u201383. https:\/\/doi.org\/10.1111\/jnc.13587","journal-title":"J Neurochem"},{"key":"4786_CR43","doi-asserted-by":"publisher","first-page":"636172","DOI":"10.3389\/fnins.2021.636172","volume":"15","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Song W, Zhao B, Xie J, Sun Q, Shi X et al (2021) Quercetin Attenuates Diabetic Peripheral Neuropathy by Correcting Mitochondrial Abnormality via Activation of AMPK\/PGC-1\u03b1 Pathway in vivo and in vitro. Front Neurosci 15:636172. https:\/\/doi.org\/10.3389\/fnins.2021.636172","journal-title":"Front Neurosci"},{"issue":"12","key":"4786_CR44","doi-asserted-by":"publisher","first-page":"3737","DOI":"10.1093\/brain\/awz324","volume":"142","author":"K Chandrasekaran","year":"2019","unstructured":"Chandrasekaran K, Salimian M, Konduru SR, Choi J, Kumar P, Long A et al (2019) Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy. Brain: J Neurol 142(12):3737\u201352. https:\/\/doi.org\/10.1093\/brain\/awz324","journal-title":"Brain: J Neurol"},{"issue":"9","key":"4786_CR45","doi-asserted-by":"publisher","first-page":"4595","DOI":"10.4049\/jimmunol.1202584","volume":"190","author":"VK Nimmagadda","year":"2013","unstructured":"Nimmagadda VK, Bever CT, Vattikunta NR, Talat S, Ahmad V, Nagalla NK et al (2013) Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets. J Immunol\u00a0(Baltimore, Md\u202f: 1950) 190(9):4595\u2013607. https:\/\/doi.org\/10.4049\/jimmunol.1202584","journal-title":"J Immunol\u00a0(Baltimore, Md : 1950)"},{"issue":"12","key":"4786_CR46","doi-asserted-by":"publisher","first-page":"5787","DOI":"10.1002\/ptr.7984","volume":"37","author":"M Hu","year":"2023","unstructured":"Hu M, Jiang W, Ye C, Hu T, Yu Q, Meng M et al (2023) Honokiol attenuates high glucose-induced peripheral neuropathy via inhibiting ferroptosis and activating AMPK\/SIRT1\/PGC-1\u03b1 pathway in Schwann cells. Phytother Res: PTR 37(12):5787\u2013802. https:\/\/doi.org\/10.1002\/ptr.7984","journal-title":"Phytother Res: PTR"},{"issue":"12","key":"4786_CR47","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","volume":"23","author":"F Yeung","year":"2004","unstructured":"Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA et al (2004) Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. Embo J 23(12):2369\u201380. https:\/\/doi.org\/10.1038\/sj.emboj.7600244","journal-title":"Embo J"},{"issue":"4","key":"4786_CR48","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","volume":"147","author":"N Mizushima","year":"2011","unstructured":"Mizushima N, Komatsu M (2011) Autophagy: renovation of cells and tissues. Cell 147(4):728\u201341. https:\/\/doi.org\/10.1016\/j.cell.2011.10.026","journal-title":"Cell"},{"issue":"1","key":"4786_CR49","first-page":"E215","volume":"19","author":"J Shen","year":"2016","unstructured":"Shen J, Fang J, Hao J, Zhong X, Wang D, Ren H et al (2016) SIRT1 Inhibits the Catabolic Effect of IL-1\u03b2 Through TLR2\/SIRT1\/NF-\u03baB Pathway in Human Degenerative Nucleus Pulposus Cells. Pain Physician 19(1):E215\u2013E226.","journal-title":"Pain Physician"},{"issue":"11","key":"4786_CR50","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1523\/jneurosci.1259-19.2020","volume":"40","author":"C Zhou","year":"2020","unstructured":"Zhou C, Wu Y, Ding X, Shi N, Cai Y, Pan ZZ (2020) SIRT1 Decreases Emotional Pain Vulnerability with Associated CaMKII\u03b1 Deacetylation in Central Amygdala. J Neurosci 40(11):2332\u201342. https:\/\/doi.org\/10.1523\/jneurosci.1259-19.2020","journal-title":"J Neurosci"},{"issue":"1","key":"4786_CR51","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1038\/s41598-018-19767-3","volume":"8","author":"D Romeo-Guitart","year":"2018","unstructured":"Romeo-Guitart D, For\u00e9s J, Herrando-Grabulosa M, Valls R, Leiva-Rodr\u00edguez T, Galea E et al (2018) Neuroprotective Drug for Nerve Trauma Revealed Using Artificial Intelligence. Sci Reports 8(1):1879. https:\/\/doi.org\/10.1038\/s41598-018-19767-3","journal-title":"Sci Reports"},{"issue":"5","key":"4786_CR52","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/s41419-018-0553-6","volume":"9","author":"D Romeo-Guitart","year":"2018","unstructured":"Romeo-Guitart D, Leiva-Rodr\u00edguez T, Espinosa-Alcantud M, Sima N, Vaquero A, Dom\u00ednguez-Mart\u00edn H et al (2018) SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons. Cell Death Dis 9(5):531. https:\/\/doi.org\/10.1038\/s41419-018-0553-6","journal-title":"Cell Death Dis"},{"issue":"7117","key":"4786_CR53","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature05354","volume":"444","author":"JA Baur","year":"2006","unstructured":"Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A et al (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nat 444(7117):337\u201342. https:\/\/doi.org\/10.1038\/nature05354","journal-title":"Nat"},{"issue":"6","key":"4786_CR54","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","volume":"127","author":"M Lagouge","year":"2006","unstructured":"Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F et al (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127(6):1109\u201322. https:\/\/doi.org\/10.1016\/j.cell.2006.11.013","journal-title":"Cell"},{"issue":"3","key":"4786_CR55","doi-asserted-by":"publisher","first-page":"e76","DOI":"10.1371\/journal.pmed.0040076","volume":"4","author":"AE Civitarese","year":"2007","unstructured":"Civitarese AE, Carling S, Heilbronn LK, Hulver MH, Ukropcova B, Deutsch WA et al (2007) Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med 4(3):e76. https:\/\/doi.org\/10.1371\/journal.pmed.0040076","journal-title":"PLoS Med"},{"issue":"5746","key":"4786_CR56","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1126\/science.1117728","volume":"310","author":"E Nisoli","year":"2005","unstructured":"Nisoli E, Tonello C, Cardile A, Cozzi V, Bracale R, Tedesco L et al (2005) Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Sci (New York, NY) 310(5746):314\u20137. https:\/\/doi.org\/10.1126\/science.1117728","journal-title":"Sci (New York, NY)"},{"issue":"37","key":"4786_CR57","doi-asserted-by":"publisher","first-page":"14855","DOI":"10.1073\/pnas.0704329104","volume":"104","author":"I Mattagajasingh","year":"2007","unstructured":"Mattagajasingh I, Kim CS, Naqvi A, Yamamori T, Hoffman TA, Jung SB et al (2007) SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc National Acad Sci U. S. A. 104(37):14855\u201360. https:\/\/doi.org\/10.1073\/pnas.0704329104","journal-title":"Proc National Acad Sci U. S. A."},{"issue":"7293","key":"4786_CR58","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1038\/nature08991","volume":"464","author":"M Iwabu","year":"2010","unstructured":"Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M et al (2010) Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK\/SIRT1. Nat 464(7293):1313\u20139. https:\/\/doi.org\/10.1038\/nature08991","journal-title":"Nat"},{"issue":"11","key":"4786_CR59","doi-asserted-by":"publisher","first-page":"4281","DOI":"10.1172\/jci58554","volume":"121","author":"S Schenk","year":"2011","unstructured":"Schenk S, McCurdy CE, Philp A, Chen MZ, Holliday MJ, Bandyopadhyay GK et al (2011) Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. The Journal of clinical investigation 121(11):4281\u20138. https:\/\/doi.org\/10.1172\/jci58554","journal-title":"The Journal of clinical investigation"}],"updated-by":[{"DOI":"10.1007\/s12035-026-05945-2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000}}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-04786-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-04786-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-04786-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:41:03Z","timestamp":1780724463000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-04786-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":59,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["4786"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-04786-9","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"15 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised to correct the misplaced image in the bottom-right column (STR 1720) of Figure 8.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2026","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s12035-026-05945-2","URL":"https:\/\/doi.org\/10.1007\/s12035-026-05945-2","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animals received treatment and care adhering to the guidelines set forth by the Institutional Animal Care and Use Committee or the Panel of Taichung Veterans General Hospital (La-1121989).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}