{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:05:43Z","timestamp":1793318743036,"version":"4.5.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s12035-025-04845-1","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T20:09:09Z","timestamp":1743106149000},"page":"9625-9637","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Caffeine and Exercise: A Dual Approach to Combat Cognitive Decline Induced by REM Sleep Deprivation"],"prefix":"10.1007","volume":"62","author":[{"given":"Sadegh Moradi","family":"Vastegani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynab Behdarvand","family":"Margha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaghoob","family":"Farbood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Sarkaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Esmaeil","family":"Khoshnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"4845_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1188306","volume":"17","author":"M Que","year":"2023","unstructured":"Que M et al (2023) Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders? Front Cell Neurosci 17:1188306","journal-title":"Front Cell Neurosci"},{"issue":"6","key":"4845_CR2","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1177\/0018720815571935","volume":"57","author":"CD Wickens","year":"2015","unstructured":"Wickens CD et al (2015) The impact of sleep disruption on complex cognitive tasks: a meta-analysis. Hum Factors 57(6):930\u2013946","journal-title":"Hum Factors"},{"issue":"1","key":"4845_CR3","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/s41386-019-0478-5","volume":"45","author":"C Wang","year":"2020","unstructured":"Wang C, Holtzman DM (2020) Bidirectional relationship between sleep and Alzheimer\u2019s disease: role of amyloid, tau, and other factors. Neuropsychopharmacology 45(1):104\u2013120","journal-title":"Neuropsychopharmacology"},{"key":"4845_CR4","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.bbi.2020.05.077","volume":"89","author":"F Medina-Flores","year":"2020","unstructured":"Medina-Flores F et al (2020) Sleep loss disrupts pericyte-brain endothelial cell interactions impairing blood-brain barrier function. Brain Behav Immun 89:118\u2013132","journal-title":"Brain Behav Immun"},{"issue":"7","key":"4845_CR5","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.tins.2019.05.001","volume":"42","author":"VA Cuddapah","year":"2019","unstructured":"Cuddapah VA, Zhang SL, Sehgal A (2019) Regulation of the blood\u2013brain barrier by circadian rhythms and sleep. Trends Neurosci 42(7):500\u2013510","journal-title":"Trends Neurosci"},{"key":"4845_CR6","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s12035-015-9236-9","volume":"52","author":"A Sharma","year":"2015","unstructured":"Sharma A et al (2015) Sleep deprivation-induced blood-brain barrier breakdown and brain dysfunction are exacerbated by size-related exposure to Ag and Cu nanoparticles. Neuroprotective effects of a 5-HT 3 receptor antagonist ondansetron. Mol Neurobiol 52:867\u2013881","journal-title":"Mol Neurobiol"},{"key":"4845_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.563916","volume":"11","author":"J Sun","year":"2020","unstructured":"Sun J et al (2020) Sleep deprivation induces cognitive impairment by increasing blood-brain barrier permeability via CD44. Front Neurol 11:563916","journal-title":"Front Neurol"},{"key":"4845_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11910-018-0868-9","volume":"18","author":"NN Aalling","year":"2018","unstructured":"Aalling NN, Nedergaard M, DiNuzzo M (2018) Cerebral metabolic changes during sleep. Curr Neurol Neurosci Rep 18:1\u201317","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"1","key":"4845_CR9","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.bbr.2011.09.017","volume":"226","author":"KH Alzoubi","year":"2012","unstructured":"Alzoubi KH et al (2012) The neuroprotective effect of vitamin E on chronic sleep deprivation-induced memory impairment: the role of oxidative stress. Behav Brain Res 226(1):205\u2013210","journal-title":"Behav Brain Res"},{"key":"4845_CR10","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.brainresbull.2017.12.012","volume":"137","author":"C Lu","year":"2018","unstructured":"Lu C et al (2018) The protective effect of 20 (S)-protopanaxadiol (PPD) against chronic sleep deprivation (CSD)-induced memory impairments in mice. Brain Res Bull 137:249\u2013256","journal-title":"Brain Res Bull"},{"key":"4845_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2020.112823","volume":"217","author":"KH Alzoubi","year":"2020","unstructured":"Alzoubi KH, Al-Jamal FF, Mahasneh AF (2020) Cerebrolysin prevents sleep deprivation induced memory impairment and oxidative stress. Physiol Behav 217:112823","journal-title":"Physiol Behav"},{"issue":"6","key":"4845_CR12","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1007\/s11064-023-04054-z","volume":"49","author":"R Belali","year":"2024","unstructured":"Belali R et al (2024) Anandamide attenuates neurobehavioral deficits and EEG irregularities in the chronic sleep deprivation rats: the role of oxidative stress and neuroinflammation. Neurochem Res 49(6):1541\u20131555","journal-title":"Neurochem Res"},{"issue":"5","key":"4845_CR13","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1007\/s11011-023-01192-9","volume":"38","author":"P Arvin","year":"2023","unstructured":"Arvin P et al (2023) Administration of growth hormone ameliorates adverse effects of total sleep deprivation. Metab Brain Dis 38(5):1671\u20131681","journal-title":"Metab Brain Dis"},{"key":"4845_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2023.102336","volume":"101","author":"R Belali","year":"2023","unstructured":"Belali R et al (2023) Anandamide improves food intake and orexinergic neuronal activity in the chronic sleep deprivation induction model in rats by modulating the expression of the CB1 receptor in the lateral hypothalamus. Neuropeptides 101:102336","journal-title":"Neuropeptides"},{"issue":"6","key":"4845_CR15","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s00213-023-06369-9","volume":"240","author":"P Arvin","year":"2023","unstructured":"Arvin P et al (2023) Exogenous growth hormone administration during total sleep deprivation changed the microRNA-9 and dopamine D2 receptor expressions followed by improvement in the hippocampal synaptic potential, spatial cognition, and inflammation in rats. Psychopharmacology 240(6):1299\u20131312","journal-title":"Psychopharmacology"},{"issue":"3","key":"4845_CR16","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3390\/clockssleep2030024","volume":"2","author":"J Wu","year":"2020","unstructured":"Wu J, Dou Y, Ladiges WC (2020) Adverse neurological effects of short-term sleep deprivation in aging mice are prevented by SS31 peptide. Clocks & sleep 2(3):325\u2013333","journal-title":"Clocks & sleep"},{"issue":"8","key":"4845_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12081600","volume":"12","author":"VS Neculicioiu","year":"2023","unstructured":"Neculicioiu VS et al (2023) Sleep deprivation-induced oxidative stress in rat models: a scoping systematic review. Antioxidants 12(8):1600","journal-title":"Antioxidants"},{"key":"4845_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.596017","volume":"12","author":"N Jiang","year":"2022","unstructured":"Jiang N et al (2022) The cognitive-enhancing effects of Dendrobium nobile Lindl extract in sleep deprivation-induced amnesic mice. Front Psych 12:596017","journal-title":"Front Psych"},{"issue":"1","key":"4845_CR19","doi-asserted-by":"publisher","first-page":"15360","DOI":"10.1038\/s41598-023-42758-y","volume":"13","author":"R Shah","year":"2023","unstructured":"Shah R et al (2023) Mild sleep restriction increases endothelial oxidative stress in female persons. Sci Rep 13(1):15360","journal-title":"Sci Rep"},{"key":"4845_CR20","doi-asserted-by":"crossref","unstructured":"Kang J-Y et al (2024) Sleep deprivation in adolescent mice impairs long-term memory till early adulthood via suppression of hippocampal astrocytes. Sleep 47:zsae143","DOI":"10.1093\/sleep\/zsae143"},{"key":"4845_CR21","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2174\/1745017901713010213","volume":"13","author":"BC Monteiro","year":"2017","unstructured":"Monteiro BC et al (2017) Relationship between brain-derived neurotrofic factor (Bdnf) and sleep on depression: a critical review. Clin Pract Epidemiol Ment Health: CP & EMH 13:213","journal-title":"Clin Pract Epidemiol Ment Health: CP & EMH"},{"key":"4845_CR22","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ijpsycho.2015.11.008","volume":"99","author":"BL Giacobbo","year":"2016","unstructured":"Giacobbo BL et al (2016) Could BDNF be involved in compensatory mechanisms to maintain cognitive performance despite acute sleep deprivation? An exploratory study. Int J Psychophysiol 99:96\u2013102","journal-title":"Int J Psychophysiol"},{"issue":"1\u20132","key":"4845_CR23","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3109\/07853890.2015.1131327","volume":"48","author":"K Schmitt","year":"2016","unstructured":"Schmitt K, Holsboer-Trachsler E, Eckert A (2016) BDNF in sleep, insomnia, and sleep deprivation. Ann Med 48(1\u20132):42\u201351","journal-title":"Ann Med"},{"key":"4845_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmcr.2024.100138","volume":"10","author":"VS Reddy","year":"2024","unstructured":"Reddy VS et al (2024) Pharmacology of caffeine and its effects on the human body. European Journal of Medicinal Chemistry Reports 10:100138","journal-title":"European Journal of Medicinal Chemistry Reports"},{"issue":"s1","key":"4845_CR25","doi-asserted-by":"publisher","first-page":"S85","DOI":"10.3233\/JAD-2010-091315","volume":"20","author":"A Nehlig","year":"2010","unstructured":"Nehlig A (2010) Is caffeine a cognitive enhancer? Journal of Alzheimer\u2019s Disease 20(s1):S85\u2013S94","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"1","key":"4845_CR26","doi-asserted-by":"publisher","first-page":"14381","DOI":"10.1038\/s41598-021-93849-7","volume":"11","author":"H Kim","year":"2021","unstructured":"Kim H et al (2021) Drinking coffee enhances neurocognitive function by reorganizing brain functional connectivity. Sci Rep 11(1):14381","journal-title":"Sci Rep"},{"issue":"16","key":"4845_CR27","doi-asserted-by":"publisher","first-page":"3994","DOI":"10.1016\/j.bmcl.2016.06.091","volume":"26","author":"B Jasiewicz","year":"2016","unstructured":"Jasiewicz B et al (2016) Antioxidant properties of thio-caffeine derivatives: identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl) sulfanyl] caffeine as antioxidant and highly potent cytoprotective agent. Bioorg Med Chem Lett 26(16):3994\u20133998","journal-title":"Bioorg Med Chem Lett"},{"issue":"4","key":"4845_CR28","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.5114\/aoms.2019.85461","volume":"15","author":"I Kaczmarczyk-Sedlak","year":"2019","unstructured":"Kaczmarczyk-Sedlak I et al (2019) Effect of caffeine on biomarkers of oxidative stress in lenses of rats with streptozotocin-induced diabetes. Archives of medical science: AMS 15(4):1073","journal-title":"Archives of medical science: AMS"},{"issue":"9","key":"4845_CR29","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1139\/cjpp-2015-0502","volume":"94","author":"I Caravan","year":"2016","unstructured":"Caravan I et al (2016) Modulatory effects of caffeine on oxidative stress and anxiety-like behavior in ovariectomized rats. Can J Physiol Pharmacol 94(9):961\u2013972","journal-title":"Can J Physiol Pharmacol"},{"issue":"3","key":"4845_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12030554","volume":"12","author":"T Eichwald","year":"2023","unstructured":"Eichwald T et al (2023) Anti-inflammatory effect of caffeine on muscle under lipopolysaccharide-induced inflammation. Antioxidants 12(3):554","journal-title":"Antioxidants"},{"issue":"1","key":"4845_CR31","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1123\/ijsnem.2015-0052","volume":"26","author":"P Tauler","year":"2016","unstructured":"Tauler P et al (2016) Effects of caffeine supplementation on plasma and blood mononuclear cell interleukin-10 levels after exercise. Int J Sport Nutr Exerc Metab 26(1):8\u201316","journal-title":"Int J Sport Nutr Exerc Metab"},{"issue":"7","key":"4845_CR32","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1249\/MSS.0b013e3182857c8a","volume":"45","author":"P Tauler","year":"2013","unstructured":"Tauler P et al (2013) Effects of caffeine on the inflammatory response induced by a 15-km run competition. Med Sci Sports Exerc 45(7):1269\u20131276","journal-title":"Med Sci Sports Exerc"},{"issue":"10","key":"4845_CR33","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1111\/ejn.13092","volume":"42","author":"IA Alhaider","year":"2015","unstructured":"Alhaider IA, Alkadhi KA (2015) Caffeine treatment prevents rapid eye movement sleep deprivation-induced impairment of late-phase long-term potentiation in the dentate gyrus. Eur J Neurosci 42(10):2843\u20132850","journal-title":"Eur J Neurosci"},{"issue":"1","key":"4845_CR34","first-page":"33475","volume":"15","author":"A Mahindru","year":"2023","unstructured":"Mahindru A, Patil P, Agrawal V (2023) Role of physical activity on mental health and well-being: a review. Cureus 15(1):33475","journal-title":"Cureus"},{"key":"4845_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2021.147367","volume":"1759","author":"L Sahin","year":"2021","unstructured":"Sahin L et al (2021) Mild regular treadmill exercise ameliorated the detrimental effects of acute sleep deprivation on spatial memory. Brain Res 1759:147367","journal-title":"Brain Res"},{"issue":"9","key":"4845_CR36","doi-asserted-by":"publisher","DOI":"10.3390\/sports11090163","volume":"11","author":"E Yoshida","year":"2023","unstructured":"Yoshida E, Hayashida H (2023) Influence of practice periodization and sleep duration on oxidative stress in high school judo athletes. Sports 11(9):163","journal-title":"Sports"},{"issue":"15","key":"4845_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158713","volume":"23","author":"M El Assar","year":"2022","unstructured":"El Assar M et al (2022) Effect of physical activity\/exercise on oxidative stress and inflammation in muscle and vascular aging. Int J Mol Sci 23(15):8713","journal-title":"Int J Mol Sci"},{"key":"4845_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.773539","volume":"12","author":"B So","year":"2022","unstructured":"So B et al (2022) Effect of aerobic exercise on oxidative stress and inflammatory response during particulate matter exposure in mouse lungs. Front Physiol 12:773539","journal-title":"Front Physiol"},{"issue":"3","key":"4845_CR39","first-page":"502","volume":"12","author":"MT Schmolesky","year":"2013","unstructured":"Schmolesky MT, Webb DL, Hansen RA (2013) The effects of aerobic exercise intensity and duration on levels of brain-derived neurotrophic factor in healthy men. J Sports Sci Med 12(3):502","journal-title":"J Sports Sci Med"},{"key":"4845_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fspor.2022.969623","volume":"4","author":"S Takada","year":"2022","unstructured":"Takada S, Fumoto Y, Kinugawa S (2022) Ergogenic effects of caffeine are mediated by myokines. Frontiers in sports and active living 4:969623","journal-title":"Frontiers in sports and active living"},{"issue":"3","key":"4845_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/nu13030868","volume":"13","author":"J Lorenzo Calvo","year":"2021","unstructured":"Lorenzo Calvo J et al (2021) Caffeine and cognitive functions in sports: a systematic review and meta-analysis. Nutrients 13(3):868","journal-title":"Nutrients"},{"key":"4845_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.112577","volume":"281","author":"KH Alzoubi","year":"2019","unstructured":"Alzoubi KH, Al Mosabih HS, Mahasneh AF (2019) The protective effect of edaravone on memory impairment induced by chronic sleep deprivation. Psychiatry Research 281:112577","journal-title":"Psychiatry Research"},{"key":"4845_CR43","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.1007\/s12035-015-9286-z","volume":"53","author":"KH Alzoubi","year":"2016","unstructured":"Alzoubi KH et al (2016) Chronic melatonin treatment prevents memory impairment induced by chronic sleep deprivation. Mol Neurobiol 53:3439\u20133447","journal-title":"Mol Neurobiol"},{"issue":"6","key":"4845_CR44","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1007\/s12640-022-00589-1","volume":"40","author":"EE Edem","year":"2022","unstructured":"Edem EE et al (2022) Combined exposure to chronic sleep deprivation and caffeine potentiates behavioural deficits by altering neurochemical profile and synaptophysin expression in long-Evans rats. Neurotox Res 40(6):2001\u20132015","journal-title":"Neurotox Res"},{"key":"4845_CR45","doi-asserted-by":"crossref","unstructured":"Khan A et al (2019) Caffeine modulates cadmium-induced oxidative stress, neuroinflammation, and cognitive impairments by regulating Nrf-2\/HO-1 in vivo and in vitro. J Clin Med 8(5)680","DOI":"10.3390\/jcm8050680"},{"issue":"3","key":"4845_CR46","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.nbd.2011.12.039","volume":"45","author":"M Zagaar","year":"2012","unstructured":"Zagaar M et al (2012) The beneficial effects of regular exercise on cognition in REM sleep deprivation: behavioral, electrophysiological and molecular evidence. Neurobiol Dis 45(3):1153\u20131162","journal-title":"Neurobiol Dis"},{"key":"4845_CR47","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.physbeh.2017.12.030","volume":"188","author":"MA Rajizadeh","year":"2018","unstructured":"Rajizadeh MA et al (2018) Voluntary exercise impact on cognitive impairments in sleep-deprived intact female rats. Physiol Behav 188:58\u201366","journal-title":"Physiol Behav"},{"issue":"5","key":"4845_CR48","doi-asserted-by":"publisher","first-page":"573","DOI":"10.32598\/bcn.9.10.505","volume":"11","author":"MA Rajizadeh","year":"2020","unstructured":"Rajizadeh MA et al (2020) Cognitive impairments of sleep-deprived ovariectomized (OVX) female rats by voluntary exercise. Basic Clin Neurosci 11(5):573\u2013586","journal-title":"Basic Clin Neurosci"},{"key":"4845_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.146598","volume":"1729","author":"MA Rajizadeh","year":"2020","unstructured":"Rajizadeh MA et al (2020) Voluntary exercise modulates learning & memory and synaptic plasticity impairments in sleep deprived female rats. Brain Res 1729:146598","journal-title":"Brain Res"},{"issue":"6","key":"4845_CR50","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1007\/s11064-023-03877-0","volume":"48","author":"SM Vastegani","year":"2023","unstructured":"Vastegani SM et al (2023) Curcumin ameliorates neurobehavioral deficits in ambient dusty particulate matter-exposure rats: the role of oxidative stress. Neurochem Res 48(6):1798\u20131810","journal-title":"Neurochem Res"},{"key":"4845_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.114100","volume":"437","author":"SM Vastegani","year":"2023","unstructured":"Vastegani SM et al (2023) Neuroprotective effect of anethole against rotenone induced non-motor deficits and oxidative stress in rat model of Parkinson\u2019s disease. Behav Brain Res 437:114100","journal-title":"Behav Brain Res"},{"key":"4845_CR52","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00385","volume":"9","author":"NR Saunders","year":"2015","unstructured":"Saunders NR et al (2015) Markers for blood-brain barrier integrity: how appropriate is Evans blue in the twenty-first century and what are the alternatives? Front Neurosci 9:385","journal-title":"Front Neurosci"},{"issue":"11","key":"4845_CR53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0294612","volume":"18","author":"S Moradi Vastegani","year":"2023","unstructured":"Moradi Vastegani S et al (2023) Anethole attenuates motor dysfunctions, striatal neuronal activity deficiency and blood brain barrier permeability by decreasing striatal \u03b1-synuclein and oxidative stress in rotenone-induced Parkinson\u2019s disease of male rats. PLoS ONE 18(11):e0294612","journal-title":"PLoS ONE"},{"issue":"4","key":"4845_CR54","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1007\/s11011-023-01169-8","volume":"38","author":"S Hajipour","year":"2023","unstructured":"Hajipour S et al (2023) Curcumin attenuates memory impairments and long-term potentiation deficits by damping hippocampal inflammatory cytokines in lipopolysaccharide-challenged rats. Metab Brain Dis 38(4):1379\u20131388","journal-title":"Metab Brain Dis"},{"key":"4845_CR55","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.biopha.2018.04.197","volume":"104","author":"E Nabaee","year":"2018","unstructured":"Nabaee E et al (2018) Cognitive and hippocampus biochemical changes following sleep deprivation in the adult male rat. Biomed Pharmacother 104:69\u201376","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"4845_CR56","doi-asserted-by":"publisher","first-page":"751","DOI":"10.5665\/sleep.2642","volume":"36","author":"M Zagaar","year":"2013","unstructured":"Zagaar M et al (2013) Regular exercise prevents sleep deprivation associated impairment of long-term memory and synaptic plasticity in the CA1 area of the hippocampus. Sleep 36(5):751\u2013761","journal-title":"Sleep"},{"key":"4845_CR57","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2021.680042","volume":"15","author":"JI Wooden","year":"2021","unstructured":"Wooden JI et al (2021) A sensitive homecage-based novel object recognition task for rodents. Front Behav Neurosci 15:680042","journal-title":"Front Behav Neurosci"},{"key":"4845_CR58","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.bbr.2014.10.025","volume":"285","author":"B Grayson","year":"2015","unstructured":"Grayson B et al (2015) Assessment of disease-related cognitive impairments using the novel object recognition (NOR) task in rodents. Behav Brain Res 285:176\u2013193","journal-title":"Behav Brain Res"},{"key":"4845_CR59","first-page":"960","volume":"2","author":"SO \u00d6gren","year":"2010","unstructured":"\u00d6gren SO, Stiedl O (2010) Passive avoidance. Encyclopedia of psychopharmacology 2:960\u2013967","journal-title":"Encyclopedia of psychopharmacology"},{"issue":"1","key":"4845_CR60","doi-asserted-by":"publisher","first-page":"11579","DOI":"10.1038\/s41598-018-30030-7","volume":"8","author":"MH Sivakumaran","year":"2018","unstructured":"Sivakumaran MH et al (2018) The discrimination ratio derived from novel object recognition tasks as a measure of recognition memory sensitivity, not bias. Sci Rep 8(1):11579","journal-title":"Sci Rep"},{"key":"4845_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.114190","volume":"438","author":"P Arvin","year":"2023","unstructured":"Arvin P et al (2023) Therapeutic effects of growth hormone in a rat model of total sleep deprivation: evaluating behavioral, hormonal, biochemical and electrophysiological parameters. Behav Brain Res 438:114190","journal-title":"Behav Brain Res"},{"key":"4845_CR62","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2013.00106","volume":"7","author":"V Colavito","year":"2013","unstructured":"Colavito V et al (2013) Experimental sleep deprivation as a tool to test memory deficits in rodents. Front Syst Neurosci 7:106","journal-title":"Front Syst Neurosci"},{"key":"4845_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2022.101616","volume":"63","author":"RL Coulson","year":"2022","unstructured":"Coulson RL, Mourrain P, Wang GX (2022) Sleep deficiency as a driver of cellular stress and damage in neurological disorders. Sleep Med Rev 63:101616","journal-title":"Sleep Med Rev"},{"key":"4845_CR64","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.bbr.2013.07.051","volume":"256","author":"L Zhang","year":"2013","unstructured":"Zhang L et al (2013) Melatonin ameliorates cognitive impairment induced by sleep deprivation in rats: role of oxidative stress, BDNF and CaMKII. Behavioural brain research 256:72\u201381","journal-title":"Behavioural brain research"},{"key":"4845_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lfs.2019.04.028","volume":"227","author":"KH Alzoubi","year":"2019","unstructured":"Alzoubi KH, Mayyas F, Zamzam HIA (2019) Omega-3 fatty acids protects against chronic sleep-deprivation induced memory impairment. Life Sci 227:1\u20137","journal-title":"Life Sci"},{"issue":"1","key":"4845_CR66","first-page":"4576012","volume":"2016","author":"G Hurtado-Alvarado","year":"2016","unstructured":"Hurtado-Alvarado G et al (2016) Blood-brain barrier disruption induced by chronic sleep loss: low-grade inflammation may be the link. J Immunol Res 2016(1):4576012","journal-title":"J Immunol Res"},{"issue":"11","key":"4845_CR67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167236","volume":"11","author":"G Hurtado-Alvarado","year":"2016","unstructured":"Hurtado-Alvarado G et al (2016) A2A adenosine receptor antagonism reverts the blood-brain barrier dysfunction induced by sleep restriction. PLoS ONE 11(11):e0167236","journal-title":"PLoS ONE"},{"key":"4845_CR68","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.bbi.2017.11.009","volume":"69","author":"G Hurtado-Alvarado","year":"2018","unstructured":"Hurtado-Alvarado G et al (2018) The yin\/yang of inflammatory status: blood-brain barrier regulation during sleep. Brain Behav Immun 69:154\u2013166","journal-title":"Brain Behav Immun"},{"key":"4845_CR69","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00132","volume":"10","author":"S Soto-Rodriguez","year":"2016","unstructured":"Soto-Rodriguez S et al (2016) Rapid eye movement sleep deprivation produces long-term detrimental effects in spatial memory and modifies the cellular composition of the subgranular zone. Front Cell Neurosci 10:132","journal-title":"Front Cell Neurosci"},{"issue":"4","key":"4845_CR70","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.nlm.2011.07.004","volume":"96","author":"JG McCoy","year":"2011","unstructured":"McCoy JG, Strecker RE (2011) The cognitive cost of sleep lost. Neurobiol Learn Mem 96(4):564\u2013582","journal-title":"Neurobiol Learn Mem"},{"issue":"1","key":"4845_CR71","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/jmi.12583","volume":"268","author":"G Hurtado-Alvarado","year":"2017","unstructured":"Hurtado-Alvarado G, Vel\u00e1zquez-Moctezuma J, G\u00f3mez-Gonz\u00e1lez B (2017) Chronic sleep restriction disrupts interendothelial junctions in the hippocampus and increases blood\u2013brain barrier permeability. J Microsc 268(1):28\u201338","journal-title":"J Microsc"},{"issue":"2","key":"4845_CR72","doi-asserted-by":"publisher","first-page":"3101","DOI":"10.18632\/aging.202503","volume":"13","author":"Y-P Xu","year":"2021","unstructured":"Xu Y-P et al (2021) Sleep deprivation aggravates brain injury after experimental subarachnoid hemorrhage via TLR4-MyD88 pathway. Aging (Albany NY) 13(2):3101","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"4845_CR73","volume":"2015","author":"G Villafuerte","year":"2015","unstructured":"Villafuerte G et al (2015) Sleep deprivation and oxidative stress in animal models: a systematic review. Oxid Med Cell Longev 2015(1):234952","journal-title":"Oxid Med Cell Longev"},{"issue":"7","key":"4845_CR74","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1016\/j.freeradbiomed.2010.07.007","volume":"49","author":"JR Prasanthi","year":"2010","unstructured":"Prasanthi JR et al (2010) Caffeine protects against oxidative stress and Alzheimer\u2019s disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. Free Radical Biol Med 49(7):1212\u20131220","journal-title":"Free Radical Biol Med"},{"issue":"5","key":"4845_CR75","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11050826","volume":"11","author":"J Souza","year":"2022","unstructured":"Souza J et al (2022) Physical-exercise-induced antioxidant effects on the brain and skeletal muscle. Antioxidants 11(5):826","journal-title":"Antioxidants"},{"key":"4845_CR76","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2024.148776","volume":"1829","author":"Z Beiyu","year":"2024","unstructured":"Beiyu Z et al (2024) Oxidative stress is associated with A\u03b2 accumulation in chronic sleep deprivation model. Brain Res 1829:148776","journal-title":"Brain Res"},{"key":"4845_CR77","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00632","volume":"10","author":"A Alagan","year":"2019","unstructured":"Alagan A et al (2019) Protective effects of Phyllanthus amarus against lipopolysaccharide-induced neuroinflammation and cognitive impairment in rats. Front Pharmacol 10:632","journal-title":"Front Pharmacol"},{"key":"4845_CR78","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.1013933","volume":"15","author":"J Yang","year":"2022","unstructured":"Yang J et al (2022) New insight into neurological degeneration: inflammatory cytokines and blood\u2013brain barrier. Front Mol Neurosci 15:1013933","journal-title":"Front Mol Neurosci"},{"issue":"3","key":"4845_CR79","doi-asserted-by":"publisher","first-page":"295","DOI":"10.55782\/ane-2022-028","volume":"82","author":"F Farokhi-Sisakht","year":"2022","unstructured":"Farokhi-Sisakht F et al (2022) Effect of intranasal administration of caffeine on mPFC ischemia-induced cognitive impairment in BALB\/c mice. Acta Neurobiol Exp 82(3):295\u2013303","journal-title":"Acta Neurobiol Exp"},{"key":"4845_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nutres.2020.05.005","volume":"80","author":"RP Barcelos","year":"2020","unstructured":"Barcelos RP et al (2020) Caffeine effects on systemic metabolism, oxidative-inflammatory pathways, and exercise performance. Nutr Res 80:1\u201317","journal-title":"Nutr Res"},{"issue":"10","key":"4845_CR81","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165823","volume":"1866","author":"D da Luz Scheffer","year":"2020","unstructured":"da Luz Scheffer D, Latini A (2020) Exercise-induced immune system response: anti-inflammatory status on peripheral and central organs. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1866(10):165823","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"issue":"1","key":"4845_CR82","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12970-020-00375-4","volume":"17","author":"L Rodas","year":"2020","unstructured":"Rodas L et al (2020) Caffeine supplementation induces higher IL-6 and IL-10 plasma levels in response to a treadmill exercise test. J Int Soc Sports Nutr 17(1):47","journal-title":"J Int Soc Sports Nutr"},{"key":"4845_CR83","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175149","volume":"930","author":"Z-R Li","year":"2022","unstructured":"Li Z-R et al (2022) Sleep deprivation leads to further impairment of hippocampal synaptic plasticity by suppressing melatonin secretion in the pineal gland of chronically unpredictable stress rats. Eur J Pharmacol 930:175149","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"4845_CR84","doi-asserted-by":"publisher","first-page":"995","DOI":"10.15212\/CVIA.2022.0013","volume":"7","author":"W Wang","year":"2022","unstructured":"Wang W et al (2022) The role of sleep deprivation in arrhythmias. Cardiovascular Innovations and Applications 7(1):995","journal-title":"Cardiovascular Innovations and Applications"},{"key":"4845_CR85","doi-asserted-by":"crossref","unstructured":"Havekes R et al (2016) Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1. eLife 23(5):13424","DOI":"10.7554\/eLife.13424"},{"issue":"2","key":"4845_CR86","doi-asserted-by":"publisher","first-page":"176","DOI":"10.4161\/auto.7.2.14074","volume":"7","author":"S Saiki","year":"2011","unstructured":"Saiki S et al (2011) Caffeine induces apoptosis by enhancement of autophagy via PI3K\/Akt\/mTOR\/p70S6K inhibition. Autophagy 7(2):176\u2013187","journal-title":"Autophagy"},{"issue":"3","key":"4845_CR87","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.3892\/mmr.2017.6894","volume":"16","author":"H Liu","year":"2017","unstructured":"Liu H, Zhou Y, Tang L (2017) Caffeine induces sustained apoptosis of human gastric cancer cells by activating the caspase-9\/caspase-3 signalling pathway. Mol Med Rep 16(3):2445\u20132454","journal-title":"Mol Med Rep"},{"issue":"2","key":"4845_CR88","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.biochi.2011.08.007","volume":"94","author":"E Tellone","year":"2012","unstructured":"Tellone E et al (2012) Caffeine inhibits erythrocyte membrane derangement by antioxidant activity and by blocking caspase 3 activation. Biochimie 94(2):393\u2013402","journal-title":"Biochimie"},{"key":"4845_CR89","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.bbrc.2020.11.029","volume":"534","author":"G Xie","year":"2021","unstructured":"Xie G et al (2021) Caffeine-related effects on cognitive performance: roles of apoptosis in rat hippocampus following sleep deprivation. Biochem Biophys Res Commun 534:632\u2013638","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"4845_CR90","doi-asserted-by":"publisher","first-page":"1","DOI":"10.20463\/jenb.2018.0001","volume":"22","author":"Y Chul Jang","year":"2018","unstructured":"chul Jang Y et al (2018) Association of exercise-induced autophagy upregulation and apoptosis suppression with neuroprotection against pharmacologically induced Parkinson\u2019s disease. Journal of exercise nutrition biochemistry 22(1):1","journal-title":"Journal of exercise nutrition biochemistry"},{"key":"4845_CR91","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113952","volume":"349","author":"M-X Liu","year":"2022","unstructured":"Liu M-X et al (2022) Exercise-induced neuroprotection against cerebral ischemia\/reperfusion injury is mediated via alleviating inflammasome-induced pyroptosis. Exp Neurol 349:113952","journal-title":"Exp Neurol"},{"issue":"1","key":"4845_CR92","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41398-024-02871-6","volume":"14","author":"M Sochal","year":"2024","unstructured":"Sochal M et al (2024) Interactions between neurotrophins, mood, and physical activity under the conditions of sleep deprivation. Transl Psychiatry 14(1):158","journal-title":"Transl Psychiatry"},{"key":"4845_CR93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.sleep.2024.03.027","volume":"118","author":"Y Ning","year":"2024","unstructured":"Ning Y et al (2024) How BDNF affects working memory in acute sleep deprivation: the mediating role of spontaneous brain activity. Sleep Med 118:1\u20138","journal-title":"Sleep Med"},{"issue":"1","key":"4845_CR94","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00406-022-01431-7","volume":"273","author":"M Stazi","year":"2023","unstructured":"Stazi M et al (2023) Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice. Eur Arch Psychiatry Clin Neurosci 273(1):269\u2013281","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"1","key":"4845_CR95","first-page":"21","volume":"28","author":"A Sadeghi","year":"2021","unstructured":"Sadeghi A et al (2021) The effect of high-intensity interval training (HIIT) and caffeine supplementation on brain-derived neurotrophic factor and glial line-derived neurotrophic factor in streptozotocin-induced diabetic rats. J Kerman Univ Med Sci 28(1):21\u201331","journal-title":"J Kerman Univ Med Sci"},{"issue":"2","key":"4845_CR96","doi-asserted-by":"publisher","first-page":"348","DOI":"10.18621\/eurj.1241667","volume":"9","author":"F Bak\u0131r","year":"2023","unstructured":"Bak\u0131r F et al (2023) Effect of caffeine supplementation during treadmill exercise on hippocampal genes expression levels in adolescent rats. The European Research Journal 9(2):348\u2013358","journal-title":"The European Research Journal"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-04845-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-04845-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-04845-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T09:58:04Z","timestamp":1757152684000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-04845-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":96,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["4845"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-04845-1","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,25]]},"assertion":[{"value":"14 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"N\/A.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"N\/A.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"N\/A.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}