{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T21:19:20Z","timestamp":1774991960070,"version":"3.50.1"},"reference-count":144,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s12035-025-04917-2","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T22:17:07Z","timestamp":1744755427000},"page":"10915-10934","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Functionalized Nanoparticles: A Promising Approach for Effective Management of Alzheimer\u2019s Disease"],"prefix":"10.1007","volume":"62","author":[{"given":"Subhasri","family":"Bogadi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahendran","family":"Bhaskaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishnuvardh","family":"Ravichandran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Nesamony","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selvam","family":"Chelliah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gowthamarajan","family":"Kuppusamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gowrav Mysore","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veera Venkata Satyanarayana Reddy","family":"Karri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Mallick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farha","family":"Farahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talat","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dharmavarapu Ramanadh","family":"Babu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vetriselvan","family":"Subramaniyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"4917_CR1","doi-asserted-by":"publisher","first-page":"173554","DOI":"10.1016\/j.ejphar.2020.173554","volume":"887","author":"M Vaz","year":"2020","unstructured":"Vaz M, Silvestre S (2020) Alzheimer\u2019s disease: recent treatment strategies. Eur J Pharmacol 887:173554","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"4917_CR2","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.nano.2017.12.006","volume":"14","author":"D Carradori","year":"2018","unstructured":"Carradori D, Balducci C, Re F, Brambilla D, Le Droumaguet B, Flores O, Gaudin A, Mura S et al (2018) Antibody-functionalized polymer nanoparticle leading to memory recovery in Alzheimer\u2019s disease-like transgenic mouse model. Nanomed Nanotechnol Biol Med 14(2):609\u201318","journal-title":"Nanomed Nanotechnol Biol Med"},{"issue":"7266","key":"4917_CR3","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/461895a","volume":"461","author":"L Mucke","year":"2009","unstructured":"Mucke L (2009) Alzheimer\u2019s disease. Nature 461(7266):895\u2013897","journal-title":"Nature"},{"issue":"1","key":"4917_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jconrel.2007.05.022","volume":"122","author":"G Tosi","year":"2007","unstructured":"Tosi G, Costantino L, Rivasi F, Ruozi B, Leo E, Vergoni AV, Tacchi R, Bertolini A et al (2007) Targeting the central nervous system: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123. J Control Release 122(1):1\u20139","journal-title":"J Control Release"},{"key":"4917_CR5","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s10545-013-9608-0","volume":"36","author":"NJ Abbott","year":"2013","unstructured":"Abbott NJ (2013) Blood\u2013brain barrier structure and function and the challenges for CNS drug delivery. J Inherit Metab Dis 36:437\u2013449","journal-title":"J Inherit Metab Dis"},{"key":"4917_CR6","doi-asserted-by":"publisher","first-page":"105774","DOI":"10.1016\/j.ejps.2021.105774","volume":"161","author":"Y Cai","year":"2021","unstructured":"Cai Y, Tian Q, Liu C, Fang L (2021) Development of long-acting rivastigmine drug-in-adhesive patch utilizing ion-pair strategy and characterization of controlled release mechanism. Eur J Pharm Sci 161:105774","journal-title":"Eur J Pharm Sci"},{"key":"4917_CR7","first-page":"368","volume":"361","author":"P Sozio","year":"2012","unstructured":"Sozio P, Cerasa LS, Marinelli L, Di Stefano A (2012) Transdermal donepezil on the treatment of Alzheimer\u2019s disease. Neuropsychiatr Dis Treat 361:368","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"41","key":"4917_CR8","doi-asserted-by":"publisher","first-page":"5755","DOI":"10.2174\/0929867325666180221125759","volume":"25","author":"C Tonda-Turo","year":"2018","unstructured":"Tonda-Turo C, Origlia N, Mattu C, Accorroni A, Chiono V (2018) Current limitations in the treatment of Parkinson\u2019s and Alzheimer\u2019s diseases: state-of-the-art and future perspective of polymeric carriers. Curr Med Chem 25(41):5755\u20135771","journal-title":"Curr Med Chem"},{"issue":"8 Suppl","key":"4917_CR9","first-page":"S177","volume":"26","author":"W Wong","year":"2020","unstructured":"Wong W (2020) Economic burden of Alzheimer disease and managed care considerations. Am J Manag Care 26(8 Suppl):S177\u2013S183","journal-title":"Am J Manag Care"},{"issue":"24","key":"4917_CR10","doi-asserted-by":"publisher","first-page":"5789","DOI":"10.3390\/molecules25245789","volume":"25","author":"Z Breijyeh","year":"2020","unstructured":"Breijyeh Z, Karaman R (2020) Comprehensive review on Alzheimer\u2019s disease: causes and treatment. Molecules 25(24):5789","journal-title":"Molecules"},{"issue":"22","key":"4917_CR11","doi-asserted-by":"publisher","first-page":"5294","DOI":"10.3390\/molecules25225294","volume":"25","author":"Y Zorkina","year":"2020","unstructured":"Zorkina Y, Abramova O, Ushakova V, Morozova A, Zubkov E, Valikhov M, Melnikov P, Majouga A et al (2020) Nano carrier drug delivery systems for the treatment of neuropsychiatric disorders: advantages and limitations. Molecules 25(22):5294","journal-title":"Molecules"},{"key":"4917_CR12","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s13346-021-00940-7","volume":"11","author":"LC Fonseca","year":"2021","unstructured":"Fonseca LC, Lopes JA, Vieira J, Viegas C, Oliveira CS, Hartmann RP, Fonte P (2021) Intranasal drug delivery for treatment of Alzheimer\u2019s disease. Drug Deliv Transl Res 11:411\u2013425","journal-title":"Drug Deliv Transl Res"},{"issue":"14","key":"4917_CR13","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.2174\/1381612822666160215154218","volume":"22","author":"A Confaloni","year":"2016","unstructured":"Confaloni A, Tosto G, Tata A (2016) Promising therapies for Alzheimer\u2019s disease. Curr Pharm Des 22(14):2050\u20132056","journal-title":"Curr Pharm Des"},{"issue":"1","key":"4917_CR14","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1177\/10738584211016409","volume":"29","author":"IF Mota","year":"2023","unstructured":"Mota IF, de Lima LS, Santana BD, Gobbo GD, Bicca JV, Azevedo JR, Veras LG, Taveira RD et al (2023) Alzheimer\u2019s disease: innovative therapeutic approaches based on peptides and nanoparticles. Neuroscientist 29(1):78\u201396","journal-title":"Neuroscientist"},{"issue":"8","key":"4917_CR15","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1039\/c3nr34005h","volume":"5","author":"S Jiang","year":"2013","unstructured":"Jiang S, Win KY, Liu S, Teng CP, Zheng Y, Han MY (2013) Surface-functionalized nanoparticles for biosensing and imaging-guided therapeutics. Nanoscale 5(8):3127\u20133148","journal-title":"Nanoscale"},{"issue":"9","key":"4917_CR16","doi-asserted-by":"publisher","first-page":"4305","DOI":"10.3390\/app11094305","volume":"11","author":"L Del Amo","year":"2021","unstructured":"Del Amo L, Cano A, Ettcheto M, Souto EB, Espina M, Camins A, Garc\u00eda ML, S\u00e1nchez-L\u00f3pez E (2021) Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimer\u2019s disease. Appl Sci 11(9):4305","journal-title":"Appl Sci"},{"key":"4917_CR17","doi-asserted-by":"publisher","first-page":"5895","DOI":"10.2147\/IJN.S210876","volume":"14","author":"A Alexander","year":"2019","unstructured":"Alexander A, Agrawal M, Uddin A, Siddique S, Shehata AM, Shaker MA, Ata Ur Rahman S, Abdul MI et al (2019) Recent expansions of novel strategies towards the drug targeting into the brain. Int J Nanomed 14:5895\u2013909","journal-title":"Int J Nanomed"},{"issue":"43","key":"4917_CR18","doi-asserted-by":"publisher","first-page":"1701921","DOI":"10.1002\/smll.201701921","volume":"13","author":"YH Tsou","year":"2017","unstructured":"Tsou YH, Zhang XQ, Zhu H, Syed S, Xu X (2017) Drug delivery to the brain across the blood\u2013brain barrier using nanomaterials. Small 13(43):1701921","journal-title":"Small"},{"key":"4917_CR19","doi-asserted-by":"publisher","first-page":"115272","DOI":"10.1016\/j.biopha.2023.115272","volume":"165","author":"X Zheng","year":"2023","unstructured":"Zheng X, Ren B, Gao Y (2023) Tight junction proteins related to blood-brain barrier and their regulatory signaling pathways in ischemic stroke. Biomed Pharmacother 165:115272","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"4917_CR20","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12987-024-00557-1","volume":"21","author":"T Chen","year":"2024","unstructured":"Chen T, Dai Y, Hu C, Lin Z, Wang S, Yang J, Zeng L, Li S, Li W (2024) Cellular and molecular mechanisms of the blood\u2013brain barrier dysfunction in neurodegenerative diseases. Fluids Barriers CNS 21(1):60","journal-title":"Fluids Barriers CNS"},{"key":"4917_CR21","unstructured":"Gryka-Marton M, Grabowska AD, Szukiewicz D. Alterations in blood\u2012brain barrier (BBB) integrity related to proinflammatory cytokines."},{"issue":"12","key":"4917_CR22","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1080\/17425247.2023.2245332","volume":"20","author":"Y Wei","year":"2023","unstructured":"Wei Y, Xia X, Li H, Gao H (2023) Influence factors on and potential strategies to amplify receptor-mediated nanodrug delivery across the blood\u2013brain barrier. Expert Opin Drug Deliv 20(12):1713\u20131730","journal-title":"Expert Opin Drug Deliv"},{"issue":"2","key":"4917_CR23","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3233\/BPL-200099","volume":"6","author":"R Carecho","year":"2020","unstructured":"Carecho R, Carregosa D, Dos Santos CN (2020) Low molecular weight (poly) phenol metabolites across the blood-brain barrier: the underexplored journey. Brain Plasticity 6(2):193\u2013214","journal-title":"Brain Plasticity"},{"key":"4917_CR24","first-page":"1","volume":"26","author":"HS Ahmed","year":"2024","unstructured":"Ahmed HS (2024) The multifaceted role of L-type amino acid transporter 1 at the blood\u2013brain barrier: structural implications and therapeutic potential. Mol Neurobiol 26:1\u201320","journal-title":"Mol Neurobiol"},{"key":"4917_CR25","doi-asserted-by":"crossref","unstructured":"Varghese SM, Patel S, Nandan A, Jose A, Ghosh S, Sah RK, Menon B, Athira KV et al (2024) Unraveling the role of the blood-brain barrier in the pathophysiology of depression: recent advances and future perspectives. Mol Neurobiol 1\u201350","DOI":"10.1007\/s12035-024-04205-5"},{"key":"4917_CR26","doi-asserted-by":"crossref","unstructured":"Lacoste B, Prat A, Freitas-Andrade M, Gu C (2024) The blood\u2013brain barrier: composition, properties, and roles in brain health. Cold Spring Harbor Perspect Biol a041422","DOI":"10.1101\/cshperspect.a041422"},{"issue":"19","key":"4917_CR27","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.3390\/cancers16193300","volume":"16","author":"M Duan","year":"2024","unstructured":"Duan M, Cao R, Yang Y, Chen X, Liu L, Ren B, Wang L, Goh BC (2024) Blood\u2013brain barrier conquest in glioblastoma nanomedicine: strategies, clinical advances, and emerging challenges. Cancers 16(19):3300","journal-title":"Cancers"},{"issue":"11","key":"4917_CR28","doi-asserted-by":"publisher","first-page":"5430","DOI":"10.1021\/acs.molpharmaceut.4c00604","volume":"21","author":"C Culkins","year":"2024","unstructured":"Culkins C, Adomanis R, Phan N, Robinson B, Slaton E, Lothrop E, Chen Y, Kimmel BR (2024) Unlocking the gates: therapeutic agents for noninvasive drug delivery across the blood-brain barrier. Mol Pharm 21(11):5430\u201354","journal-title":"Mol Pharm"},{"issue":"9","key":"4917_CR29","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.3390\/pharmaceutics15092271","volume":"15","author":"W Zhang","year":"2023","unstructured":"Zhang W, Zhu D, Tong Z, Peng B, Cheng X, Esser L, Voelcker NH (2023) Influence of surface ligand density and particle size on the penetration of the blood\u2013brain barrier by porous silicon nanoparticles. Pharmaceutics 15(9):2271","journal-title":"Pharmaceutics"},{"issue":"8","key":"4917_CR30","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.3390\/ph17081070","volume":"17","author":"AK Madadi","year":"2024","unstructured":"Madadi AK, Sohn MJ (2024) Advances in intrathecal nanoparticle delivery: targeting the blood\u2013cerebrospinal fluid barrier for enhanced CNS drug delivery. Pharmaceuticals 17(8):1070","journal-title":"Pharmaceuticals"},{"issue":"3","key":"4917_CR31","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1021\/acsnano.3c10674","volume":"18","author":"S Zha","year":"2024","unstructured":"Zha S, Liu H, Li H, Li H, Wong KL, All AH (2024) Functionalized nanomaterials capable of crossing the blood\u2013brain barrier. ACS Nano 18(3):1820\u20131845","journal-title":"ACS Nano"},{"key":"4917_CR32","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.actbio.2024.09.027","volume":"189","author":"MI Teixeira","year":"2024","unstructured":"Teixeira MI, Lopes CM, Amaral MH, Costa PC (2024) Navigating neurotoxicity and safety assessment of nanocarriers for brain delivery: evaluation models and insights. Acta Biomaterialia 189:25\u201356","journal-title":"Acta Biomaterialia"},{"issue":"2","key":"4917_CR33","doi-asserted-by":"publisher","first-page":"599","DOI":"10.3233\/JAD-230792","volume":"97","author":"F Ricci","year":"2024","unstructured":"Ricci F, Martorana A, Bonomi CG, Serafini C, Mercuri NB, Koch G, Motta C (2024) Effect of vascular risk factors on blood-brain barrier and cerebrospinal fluid biomarkers along the Alzheimer\u2019s Disease Continuum: a retrospective observational study. J Alzheimer\u2019s Dis 97(2):599\u2013607","journal-title":"J Alzheimer\u2019s Dis"},{"key":"4917_CR34","doi-asserted-by":"publisher","first-page":"136028","DOI":"10.1016\/j.jhazmat.2024.136028","volume":"480","author":"J Xie","year":"2024","unstructured":"Xie J, Sun Y, Ma Y, Wu D, Zhang Z (2024) Blood-brain barrier damage accelerates the accumulation of micro-and nanoplastics in the human central nervous system. J Hazard Mater 480:136028","journal-title":"J Hazard Mater"},{"issue":"12","key":"4917_CR35","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.3390\/pharmaceutics12121236","volume":"12","author":"K Tachibana","year":"2020","unstructured":"Tachibana K, Iwashita Y, Wakayama E, Nishino I, Nishikaji T, Kondoh M (2020) Tight junction modulating bioprobes for drug delivery system to the brain: a review. Pharmaceutics 12(12):1236","journal-title":"Pharmaceutics"},{"key":"4917_CR36","doi-asserted-by":"publisher","first-page":"120351","DOI":"10.1016\/j.ijpharm.2021.120351","volume":"599","author":"M Choudhari","year":"2021","unstructured":"Choudhari M, Hejmady S, Saha RN, Damle S, Singhvi G, Alexander A, Kesharwani P, Dubey SK (2021) Evolving new-age strategies to transport therapeutics across the blood-brain-barrier. Int J Pharm 599:120351","journal-title":"Int J Pharm"},{"key":"4917_CR37","doi-asserted-by":"publisher","first-page":"119491","DOI":"10.1016\/j.biomaterials.2019.119491","volume":"224","author":"J Xie","year":"2019","unstructured":"Xie J, Shen Z, Anraku Y, Kataoka K, Chen X (2019) Nanomaterial-based blood-brain-barrier (BBB) crossing strategies. Biomaterials 224:119491","journal-title":"Biomaterials"},{"issue":"7","key":"4917_CR38","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1517\/17425247.2013.762354","volume":"10","author":"K Nagpal","year":"2013","unstructured":"Nagpal K, Singh SK, Mishra DN (2013) Drug targeting to brain: a systematic approach to study the factors, parameters and approaches for prediction of permeability of drugs across BBB. Expert Opin Drug Deliv 10(7):927\u2013955","journal-title":"Expert Opin Drug Deliv"},{"issue":"9","key":"4917_CR39","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/j.bbamem.2019.07.008","volume":"1861","author":"AR Santa-Maria","year":"2019","unstructured":"Santa-Maria AR, Walter FR, Valkai S, Br\u00e1s AR, M\u00e9sz\u00e1ros M, Kincses A, Klepe A, Gaspar D et al (2019) Lidocaine turns the surface charge of biological membranes more positive and changes the permeability of blood-brain barrier culture models. Biochim Biophys Acta (BBA)-Biomembranes 1861(9):1579\u201391","journal-title":"Biochim Biophys Acta (BBA)-Biomembranes"},{"issue":"9\u201310","key":"4917_CR40","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1080\/10611860400015936","volume":"12","author":"PR Lockman","year":"2004","unstructured":"Lockman PR, Koziara JM, Mumper RJ, Allen DD (2004) Nanoparticle surface charges alter blood\u2013brain barrier integrity and permeability. J Drug Target 12(9\u201310):635\u2013641","journal-title":"J Drug Target"},{"issue":"12","key":"4917_CR41","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1002\/smll.200900005","volume":"5","author":"F Lu","year":"2009","unstructured":"Lu F, Wu SH, Hung Y, Mou CY (2009) Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles. Small 5(12):1408\u201313","journal-title":"Small"},{"issue":"2","key":"4917_CR42","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.3390\/ijms15021812","volume":"15","author":"S Hanada","year":"2014","unstructured":"Hanada S, Fujioka K, Inoue Y, Kanaya F, Manome Y, Yamamoto K (2014) Cell-based in vitro blood\u2013brain barrier model can rapidly evaluate nanoparticles\u2019 brain permeability in association with particle size and surface modification. Int J Mol Sci 15(2):1812\u20131825","journal-title":"Int J Mol Sci"},{"key":"4917_CR43","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.mattod.2020.02.001","volume":"37","author":"S Ding","year":"2020","unstructured":"Ding S, Khan AI, Cai X, Song Y, Lyu Z, Du D, Dutta P, Lin Y (2020) Overcoming blood\u2013brain barrier transport: advances in nanoparticle-based drug delivery strategies. Mater Today 37:112\u2013125","journal-title":"Mater Today"},{"issue":"3","key":"4917_CR44","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1124\/pr.111.005363","volume":"64","author":"JM Morachis","year":"2012","unstructured":"Morachis JM, Mahmoud EA, Almutairi A (2012) Physical and chemical strategies for therapeutic delivery by using polymeric nanoparticles. Pharmacol Rev 64(3):505\u2013519","journal-title":"Pharmacol Rev"},{"key":"4917_CR45","doi-asserted-by":"crossref","unstructured":"Lee C, Hwang HS, Lee S, Kim B, Kim JO, Oh KT, Lee ES, Choi HG (2017) Rabies virus-inspired silica-coated gold nanorods as a photothermal therapeutic platform for treating brain tumors. Adv Mater (Deerfield Beach, Fla.) 29(13).","DOI":"10.1002\/adma.201605563"},{"key":"4917_CR46","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1602\/neurorx.2.4.541","volume":"2","author":"H Pajouhesh","year":"2005","unstructured":"Pajouhesh H, Lenz GR (2005) Medicinal chemical properties of successful central nervous system drugs. NeuroRx 2:541\u2013553","journal-title":"NeuroRx"},{"issue":"1","key":"4917_CR47","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3390\/scipharm87010006","volume":"87","author":"LA Bors","year":"2019","unstructured":"Bors LA, Erd\u0151 F (2019) Overcoming the blood\u2013brain barrier. challenges and tricks for CNS drug delivery. Sci Pharm 87(1):6","journal-title":"Sci Pharm"},{"key":"4917_CR48","doi-asserted-by":"crossref","unstructured":"Lu CT, Zhao YZ, Wong HL, Cai J, Peng L, Tian XQ (2014) Current approaches to enhance CNS delivery of drugs across the brain barriers. Int J Nanomed 2241-2257","DOI":"10.2147\/IJN.S61288"},{"issue":"3","key":"4917_CR49","doi-asserted-by":"publisher","first-page":"117","DOI":"10.12793\/tcp.2017.25.3.117","volume":"25","author":"AJ Atkinson Jr","year":"2017","unstructured":"Atkinson AJ Jr (2017) Intracerebroventricular drug administration. Transl Clin Pharmacol 25(3):117","journal-title":"Transl Clin Pharmacol"},{"issue":"6","key":"4917_CR50","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1227\/00006123-198812000-00001","volume":"23","author":"RE Harbaugh","year":"1988","unstructured":"Harbaugh RE, Saunders RL, Reeder RF (1988) Use of implantable pumps for central nervous system drug infusions to treat neurological disease. Neurosurgery 23(6):693\u2013698","journal-title":"Neurosurgery"},{"issue":"3","key":"4917_CR51","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.ymgme.2018.05.003","volume":"124","author":"I Slavc","year":"2018","unstructured":"Slavc I, Cohen-Pfeffer JL, Gururangan S, Krauser J, Lim DA, Maldaun M, Schwering C, Shaywitz AJ, Westphal M (2018) Best practices for the use of intracerebroventricular drug delivery devices. Mol Genet Metab 124(3):184\u2013188","journal-title":"Mol Genet Metab"},{"issue":"3","key":"4917_CR52","doi-asserted-by":"publisher","first-page":"624","DOI":"10.3171\/2010.9.JNS101223","volume":"114","author":"JA Boockvar","year":"2011","unstructured":"Boockvar JA, Tsiouris AJ, Hofstetter CP, Kovanlikaya I, Fralin S, Kesavabhotla K, Seedial SM, Pannullo SC et al (2011) Safety and maximum tolerated dose of superselective intraarterial cerebral infusion of bevacizumab after osmotic blood-brain barrier disruption for recurrent malignant glioma. J Neurosurg 114(3):624\u2013632","journal-title":"J Neurosurg"},{"issue":"1","key":"4917_CR53","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3390\/antiox11010102","volume":"11","author":"JG McLarnon","year":"2021","unstructured":"McLarnon JG (2021) A leaky blood\u2013brain barrier to fibrinogen contributes to oxidative damage in Alzheimer\u2019s disease. Antioxidants 11(1):102","journal-title":"Antioxidants"},{"issue":"5","key":"4917_CR54","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s12272-021-01332-8","volume":"44","author":"A Uprety","year":"2021","unstructured":"Uprety A, Kang Y, Kim SY (2021) Blood-brain barrier dysfunction as a potential therapeutic target for neurodegenerative disorders. Arch Pharmacal Res 44(5):487\u2013498","journal-title":"Arch Pharmacal Res"},{"key":"4917_CR55","doi-asserted-by":"publisher","first-page":"35","DOI":"10.2165\/0023210-200923010-00003","volume":"23","author":"MM Patel","year":"2009","unstructured":"Patel MM, Goyal BR, Bhadada SV, Bhatt JS, Amin AF (2009) Getting into the brain: approaches to enhance brain drug delivery. CNS Drugs 23:35\u201358","journal-title":"CNS Drugs"},{"issue":"196","key":"4917_CR56","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jconrel.2014.09.018","volume":"28","author":"CP Foley","year":"2014","unstructured":"Foley CP, Rubin DG, Santillan A, Sondhi D, Dyke JP, Gobin YP, Crystal RG, Ballon DJ (2014) Intra-arterial delivery of AAV vectors to the mouse brain after mannitol mediated blood brain barrier disruption. J Control Release 28(196):71\u201378","journal-title":"J Control Release"},{"key":"4917_CR57","doi-asserted-by":"crossref","unstructured":"Li C, Chen L, Wang Y, Wang T, Di D, Zhang H, Zhao H, Shen X et al (2021) Protein nanoparticle-related osmotic pressure modifies nonselective permeability of the blood\u2013brain barrier by increasing membrane fluidity. Int J Nanomed 1663-1680","DOI":"10.2147\/IJN.S291286"},{"key":"4917_CR58","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/BF01060218","volume":"26","author":"TF Cloughesy","year":"1995","unstructured":"Cloughesy TF, Black KL (1995) Pharmacological blood-brain barrier modification for selective drug delivery. J Neurooncol 26:125\u2013132","journal-title":"J Neurooncol"},{"key":"4917_CR59","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1023\/A:1007074420772","volume":"20","author":"NJ Abbott","year":"2000","unstructured":"Abbott NJ (2000) Inflammatory mediators and modulation of blood\u2013brain barrier permeability. Cell Mol Neurobiol 20:131\u2013147","journal-title":"Cell Mol Neurobiol"},{"key":"4917_CR60","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.addr.2014.01.008","volume":"72","author":"M Aryal","year":"2014","unstructured":"Aryal M, Arvanitis CD, Alexander PM, McDannold N (2014) Ultrasound-mediated blood\u2013brain barrier disruption for targeted drug delivery in the central nervous system. Adv Drug Deliv Rev 72:94\u2013109","journal-title":"Adv Drug Deliv Rev"},{"issue":"7","key":"4917_CR61","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3109\/1061186X.2012.702771","volume":"20","author":"YZ Zhao","year":"2012","unstructured":"Zhao YZ, Lu CT, Li XK, Tang QQ, Tian XQ, Zhao YP, Zhang Y, Tian JL et al (2012) Improving the cardio protective effect of aFGF in ischemic myocardium with ultrasound-mediated cavitation of heparin modified microbubbles: preliminary experiment. J Drug Target 20(7):623\u2013631","journal-title":"J Drug Target"},{"issue":"1","key":"4917_CR62","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neuroimage.2004.06.046","volume":"24","author":"K Hynynen","year":"2005","unstructured":"Hynynen K, McDannold N, Sheikov NA, Jolesz FA, Vykhodtseva N (2005) Local and reversible blood\u2013brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications. Neuroimage 24(1):12\u201320","journal-title":"Neuroimage"},{"issue":"4","key":"4917_CR63","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1177\/0271678X16652630","volume":"37","author":"C Sierra","year":"2017","unstructured":"Sierra C, Acosta C, Chen C, Wu SY, Karakatsani ME, Bernal M, Konofagou EE (2017) Lipid microbubbles as a vehicle for targeted drug delivery using focused ultrasound-induced blood\u2013brain barrier opening. J Cereb Blood Flow Metab 37(4):1236\u20131250","journal-title":"J Cereb Blood Flow Metab"},{"issue":"11","key":"4917_CR64","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.3390\/pharmaceutics12111031","volume":"12","author":"M Markovic","year":"2020","unstructured":"Markovic M, Ben-Shabat S, Dahan A (2020) Prodrugs for improved drug delivery: lessons learned from recently developed and marketed products. Pharmaceutics 12(11):1031","journal-title":"Pharmaceutics"},{"issue":"4","key":"4917_CR65","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3390\/pharmaceutics10040210","volume":"10","author":"M Markovic","year":"2018","unstructured":"Markovic M, Ben-Shabat S, Keinan S, Aponick A, Zimmermann EM, Dahan A (2018) Prospects and challenges of phospholipid-based prodrugs. Pharmaceutics 10(4):210","journal-title":"Pharmaceutics"},{"issue":"5","key":"4917_CR66","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1517\/17425240902902315","volume":"6","author":"K Matsuhisa","year":"2009","unstructured":"Matsuhisa K, Kondoh M, Takahashi A, Yagi K (2009) Tight junction modulator and drug delivery. Expert Opin Drug Deliv 6(5):509\u2013515","journal-title":"Expert Opin Drug Deliv"},{"issue":"12","key":"4917_CR67","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1016\/S0196-9781(01)00537-X","volume":"22","author":"KA Witt","year":"2001","unstructured":"Witt KA, Gillespie TJ, Huber JD, Egleton RD, Davis TP (2001) Peptide drug modifications to enhance bioavailability and blood-brain barrier permeability. Peptides 22(12):2329\u20132343","journal-title":"Peptides"},{"issue":"16","key":"4917_CR68","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.2174\/1381612823666170201161037","volume":"23","author":"A Najjar","year":"2017","unstructured":"Najjar A, Rajabi N, Karaman R (2017) Recent approaches to platinum (IV) prodrugs: a variety of strategies for enhanced delivery and efficacy. Curr Pharm Des 23(16):2366\u20132376","journal-title":"Curr Pharm Des"},{"issue":"1","key":"4917_CR69","doi-asserted-by":"publisher","first-page":"71","DOI":"10.2174\/187221109787158355","volume":"3","author":"SA Pathan","year":"2009","unstructured":"Pathan SA, Iqbal Z, Zaidi S, Talegaonkar S, Vohra D, Jain GK, Azeem A, Jain N et al (2009) CNS drug delivery systems: novel approaches. Recent Pat Drug Delivery Formulation 3(1):71\u201389","journal-title":"Recent Pat Drug Delivery Formulation"},{"issue":"25","key":"4917_CR70","doi-asserted-by":"publisher","first-page":"6338","DOI":"10.1021\/jm049717d","volume":"47","author":"PD Leeson","year":"2004","unstructured":"Leeson PD, Davis AM (2004) Time-related differences in the physical property profiles of oral drugs. J Med Chem 47(25):6338\u20136348","journal-title":"J Med Chem"},{"key":"4917_CR71","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1023\/A:1008192010023","volume":"15","author":"H van de Waterbeemd","year":"2001","unstructured":"van de Waterbeemd H, Smith DA, Jones BC (2001) Lipophilicity in PK design: methyl, ethyl, futile. J Comput Aided Mol Des 15:273\u2013286","journal-title":"J Comput Aided Mol Des"},{"issue":"4","key":"4917_CR72","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nrd.2015.21","volume":"15","author":"WA Banks","year":"2016","unstructured":"Banks WA (2016) From blood\u2013brain barrier to blood\u2013brain interface: new opportunities for CNS drug delivery. Nat Rev Drug Discovery 15(4):275\u2013292","journal-title":"Nat Rev Drug Discovery"},{"issue":"10","key":"4917_CR73","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1517\/17460441.2012.714363","volume":"7","author":"JA Arnott","year":"2012","unstructured":"Arnott JA, Planey SL (2012) The influence of lipophilicity in drug discovery and design. Expert Opin Drug Discov 7(10):863\u2013875","journal-title":"Expert Opin Drug Discov"},{"issue":"2\u20133","key":"4917_CR74","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0169-409X(98)00087-8","volume":"36","author":"WM Pardridge","year":"1999","unstructured":"Pardridge WM (1999) Vector-mediated drug delivery to the brain. Adv Drug Deliv Rev 36(2\u20133):299\u2013321","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"4917_CR75","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0169-409X(00)00122-8","volume":"47","author":"J Kreuter","year":"2001","unstructured":"Kreuter J (2001) Nanoparticulate systems for brain delivery of drugs. Adv Drug Deliv Rev 47(1):65\u201381","journal-title":"Adv Drug Deliv Rev"},{"issue":"4","key":"4917_CR76","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1248\/cpb.c19-00854","volume":"68","author":"T Tashima","year":"2020","unstructured":"Tashima T (2020) Smart strategies for therapeutic agent delivery into brain across the blood\u2013brain barrier using receptor-mediated transcytosis. Chem Pharm Bull 68(4):316\u2013325","journal-title":"Chem Pharm Bull"},{"issue":"11","key":"4917_CR77","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.2217\/nnm.15.29","volume":"10","author":"Y Monsalve","year":"2015","unstructured":"Monsalve Y, Tosi G, Ruozi B, Belletti D, Vilella A, Zoli M, Vandelli MA, Forni F et al (2015) PEG-g-chitosan nanoparticles functionalized with the monoclonal antibody OX26 for brain drug targeting. Nanomedicine 10(11):1735\u20131750","journal-title":"Nanomedicine"},{"issue":"2","key":"4917_CR78","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1002\/bit.21764","volume":"100","author":"RJ Boado","year":"2008","unstructured":"Boado RJ, Zhang Y, Zhang Y, Wang Y, Pardridge WM (2008) GDNF fusion protein for targeted-drug delivery across the human blood\u2013brain barrier. Biotechnol Bioeng 100(2):387\u2013396","journal-title":"Biotechnol Bioeng"},{"issue":"11","key":"4917_CR79","doi-asserted-by":"publisher","first-page":"9999","DOI":"10.1021\/acsnano.6b04268","volume":"10","author":"T Lin","year":"2016","unstructured":"Lin T, Zhao P, Jiang Y, Tang Y, Jin H, Pan Z, He H, Yang VC et al (2016) Blood\u2013brain-barrier-penetrating albumin nanoparticles for biomimetic drug delivery via albumin-binding protein pathways for antiglioma therapy. ACS Nano 10(11):9999\u201310012","journal-title":"ACS Nano"},{"issue":"2","key":"4917_CR80","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.ejpb.2008.08.021","volume":"71","author":"K Ulbrich","year":"2009","unstructured":"Ulbrich K, Hekmatara T, Herbert E, Kreuter J (2009) Transferrin-and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood\u2013brain barrier (BBB). Eur J Pharm Biopharm 71(2):251\u2013256","journal-title":"Eur J Pharm Biopharm"},{"issue":"2\u20133","key":"4917_CR81","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.ejps.2005.03.008","volume":"25","author":"CC Visser","year":"2005","unstructured":"Visser CC, Stevanovi\u0107 S, Voorwinden LH, van Bloois L, Gaillard PJ, Danhof M, Crommelin DJ, de Boer AG (2005) Targeting liposomes with protein drugs to the blood\u2013brain barrier in vitro. Eur J Pharm Sci 25(2\u20133):299\u2013305","journal-title":"Eur J Pharm Sci"},{"issue":"211","key":"4917_CR82","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jconrel.2015.06.002","volume":"10","author":"C Fornaguera","year":"2015","unstructured":"Fornaguera C, Dols-P\u00e9rez A, Calder\u00f3 G, Garc\u00eda-Celma MJ, Camarasa J, Solans C (2015) PLGA nanoparticles prepared by nano-emulsion templating using low-energy methods as efficient nanocarriers for drug delivery across the blood\u2013brain barrier. J Control Release 10(211):134\u2013143","journal-title":"J Control Release"},{"key":"4917_CR83","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1208\/s12248-008-9055-2","volume":"10","author":"F Herv\u00e9","year":"2008","unstructured":"Herv\u00e9 F, Ghinea N, Scherrmann JM (2008) CNS delivery via adsorptive transcytosis. AAPS J 10:455\u2013472","journal-title":"AAPS J"},{"issue":"2\u20133","key":"4917_CR84","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0169-409X(98)00084-2","volume":"36","author":"A Tsuji","year":"1999","unstructured":"Tsuji A, Tamai I (1999) Carrier-mediated or specialized transport of drugs across the blood\u2013brain barrier. Adv Drug Deliv Rev 36(2\u20133):277\u2013290","journal-title":"Adv Drug Deliv Rev"},{"issue":"4","key":"4917_CR85","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.biomaterials.2012.09.047","volume":"34","author":"JY Kim","year":"2013","unstructured":"Kim JY, Choi WI, Kim YH, Tae G (2013) Brain-targeted delivery of protein using chitosan-and RVG peptide-conjugated, pluronic-based nano-carrier. Biomaterials 34(4):1170\u20131178","journal-title":"Biomaterials"},{"issue":"5","key":"4917_CR86","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1111\/cbdd.12586","volume":"86","author":"G Kamalinia","year":"2015","unstructured":"Kamalinia G, Khodagholi F, Shaerzadeh F, Tavssolian F, Chaharband F, Atyabi F, Sharifzadeh M, Amini M et al (2015) Cationic albumin-conjugated chelating agent as a novel brain drug delivery system in neurodegeneration. Chem Biol Drug Des 86(5):1203\u20131214","journal-title":"Chem Biol Drug Des"},{"issue":"35","key":"4917_CR87","doi-asserted-by":"publisher","first-page":"355102","DOI":"10.1088\/0957-4484\/21\/35\/355102","volume":"21","author":"CY Dombu","year":"2010","unstructured":"Dombu CY, Kroubi M, Zibouche R, Matran R, Betbeder D (2010) Characterization of endocytosis and exocytosis of cationic nanoparticles in airway epithelium cells. Nanotechnology 21(35):355102","journal-title":"Nanotechnology"},{"issue":"555","key":"4917_CR88","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ijpharm.2018.11.035","volume":"30","author":"VJ Muniswamy","year":"2019","unstructured":"Muniswamy VJ, Raval N, Gondaliya P, Tambe V, Kalia K, Tekade RK (2019) \u2018Dendrimer-Cationized-Albumin\u2019encrusted polymeric nanoparticle improves BBB penetration and anticancer activity of doxorubicin. Int J Pharm 30(555):77\u201399","journal-title":"Int J Pharm"},{"key":"4917_CR89","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jconrel.2017.05.019","volume":"260","author":"M Agrawal","year":"2017","unstructured":"Agrawal M, Tripathi DK, Saraf S, Saraf S, Antimisiaris SG, Mourtas S, Hammarlund-Udenaes M, Alexander A (2017) Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer\u2019s disease. J Control Release 260:61\u201377","journal-title":"J Control Release"},{"issue":"W1","key":"4917_CR90","doi-asserted-by":"publisher","first-page":"W314","DOI":"10.1093\/nar\/gku411","volume":"42","author":"DE Pires","year":"2014","unstructured":"Pires DE, Ascher DB, Blundell TL (2014) DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach. Nucleic Acids Res 42(W1):W314\u2013W319","journal-title":"Nucleic Acids Res"},{"key":"4917_CR91","doi-asserted-by":"crossref","unstructured":"Vieira DB, Gamarra LF (2016) Getting into the brain: liposome-based strategies for effective drug delivery across the blood\u2013brain barrier. Int J Nanomed 5381-414","DOI":"10.2147\/IJN.S117210"},{"issue":"7","key":"4917_CR92","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.cclet.2010.12.056","volume":"22","author":"F Lei","year":"2011","unstructured":"Lei F, Fan W, Li XK, Wang S, Hai L, Wu Y (2011) Design, synthesis and preliminary bio-evaluation of glucose\u2013cholesterol derivatives as ligands for brain targeting liposomes. Chin Chem Lett 22(7):831\u2013834","journal-title":"Chin Chem Lett"},{"key":"4917_CR93","doi-asserted-by":"crossref","unstructured":"Xie F, Yao N, Qin Y, Zhang Q, Chen H, Yuan M, Tang J, Li X et al (2012) Investigation of glucose-modified liposomes using polyethylene glycols with different chain lengths as the linkers for brain targeting. Int J Nanomed 163-75","DOI":"10.2147\/IJN.S23771"},{"key":"4917_CR94","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s40263-016-0405-9","volume":"31","author":"MM Patel","year":"2017","unstructured":"Patel MM, Patel BM (2017) Crossing the blood\u2013brain barrier: recent advances in drug delivery to the brain. CNS Drugs 31:109\u2013133","journal-title":"CNS Drugs"},{"issue":"3","key":"4917_CR95","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S0168-3659(00)00280-7","volume":"68","author":"HS Yoo","year":"2000","unstructured":"Yoo HS, Lee KH, Oh JE, Park TG (2000) In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin\u2013PLGA conjugates. J Control Release 68(3):419\u2013431","journal-title":"J Control Release"},{"issue":"2","key":"4917_CR96","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0165-0270(01)00450-2","volume":"111","author":"P Calvo","year":"2001","unstructured":"Calvo P, Gouritin B, Brigger I, Lasmezas C, Deslys JP, Williams A, Andreux JP, Dormont D et al (2001) PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases. J Neurosci Methods 111(2):151\u2013155","journal-title":"J Neurosci Methods"},{"issue":"1\u20133","key":"4917_CR97","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0168-3659(01)00338-8","volume":"74","author":"S Wroblewski","year":"2001","unstructured":"Wroblewski S, Berenson M, Kope\u010dkov\u00e1 P, Kope\u010dek J (2001) Potential of lectin-N-(2-hydroxypropyl) methacrylamide copolymer-drug conjugates for the treatment of pre-cancerous conditions. J Control Release 74(1\u20133):283\u2013293","journal-title":"J Control Release"},{"issue":"1","key":"4917_CR98","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.pharmthera.2004.08.001","volume":"104","author":"DJ Begley","year":"2004","unstructured":"Begley DJ (2004) Delivery of therapeutic agents to the central nervous system: the problems and the possibilities. Pharmacol Ther 104(1):29\u201345","journal-title":"Pharmacol Ther"},{"issue":"4","key":"4917_CR99","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3390\/pharmaceutics10040269","volume":"10","author":"DM Teleanu","year":"2018","unstructured":"Teleanu DM, Chircov C, Grumezescu AM, Volceanov A, Teleanu RI (2018) Blood-brain delivery methods using nanotechnology. Pharmaceutics 10(4):269","journal-title":"Pharmaceutics"},{"issue":"2","key":"4917_CR100","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.nano.2017.11.008","volume":"14","author":"R Dal Magro","year":"2018","unstructured":"Dal Magro R, Albertini B, Beretta S, Rigolio R, Donzelli E, Chiorazzi A, Ricci M, Blasi P et al (2018) Artificial apolipoprotein corona enables nanoparticle brain targeting. Nanomed Nanotechnol Biol Med 14(2):429\u201338","journal-title":"Nanomed Nanotechnol Biol Med"},{"issue":"2","key":"4917_CR101","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.3390\/ijms14022862","volume":"14","author":"FY Huang","year":"2013","unstructured":"Huang FY, Chen WJ, Lee WY, Lo ST, Lee TW, Lo JM (2013) In vitro and in vivo evaluation of lactoferrin-conjugated liposomes as a novel carrier to improve the brain delivery. Int J Mol Sci 14(2):2862\u20132874","journal-title":"Int J Mol Sci"},{"issue":"5","key":"4917_CR102","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.ejps.2010.05.003","volume":"40","author":"MI Alam","year":"2010","unstructured":"Alam MI, Beg S, Samad A, Baboota S, Kohli K, Ali J, Ahuja A, Akbar M (2010) Strategy for effective brain drug delivery. Eur J Pharm Sci 40(5):385\u2013403","journal-title":"Eur J Pharm Sci"},{"issue":"1","key":"4917_CR103","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.addr.2012.08.009","volume":"65","author":"A Koshkaryev","year":"2013","unstructured":"Koshkaryev A, Sawant R, Deshpande M, Torchilin V (2013) Immunoconjugates and long circulating systems: origins, current state of the art and future directions. Adv Drug Deliv Rev 65(1):24\u201335","journal-title":"Adv Drug Deliv Rev"},{"issue":"261","key":"4917_CR104","doi-asserted-by":"publisher","first-page":"261ra154","DOI":"10.1126\/scitranslmed.3009835","volume":"6","author":"YJ Yu","year":"2014","unstructured":"Yu YJ, Atwal JK, Zhang Y, Tong RK, Wildsmith KR, Tan C, Bien-Ly N, Hersom M et al (2014) Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Sci Transl Med 6(261):261ra154","journal-title":"Sci Transl Med"},{"key":"4917_CR105","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ddtec.2016.07.009","volume":"20","author":"J Paterson","year":"2016","unstructured":"Paterson J, Webster CI (2016) Exploiting transferrin receptor for delivering drugs across the blood-brain barrier. Drug Discov Today Technol 20:49\u201352","journal-title":"Drug Discov Today Technol"},{"issue":"1","key":"4917_CR106","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1046\/j.1471-4159.2001.00541.x","volume":"79","author":"T Moos","year":"2001","unstructured":"Moos T, Morgan EH (2001) Restricted transport of anti-transferrin receptor antibody (OX26) through the blood\u2013brain barrier in the rat. J Neurochem 79(1):119\u2013129","journal-title":"J Neurochem"},{"issue":"2","key":"4917_CR107","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/j.1471-4159.2007.04591.x","volume":"102","author":"JF Poduslo","year":"2007","unstructured":"Poduslo JF, Ramakrishnan M, Holasek SS, Ramirez-Alvarado M, Kandimalla KK, Gilles EJ, Curran GL, Wengenack TM (2007) In vivo targeting of antibody fragments to the nervous system for Alzheimer\u2019s disease immunotherapy and molecular imaging of amyloid plaques. J Neurochem 102(2):420\u2013433","journal-title":"J Neurochem"},{"issue":"8","key":"4917_CR108","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1097\/NEN.0b013e318225038c","volume":"70","author":"JF Poduslo","year":"2011","unstructured":"Poduslo JF, Hultman KL, Curran GL, Preboske GM, Chamberlain R, Marja\u0144ska M, Garwood M, Jack CR Jr et al (2011) Targeting vascular amyloid in arterioles of Alzheimer disease transgenic mice with amyloid \u03b2 protein antibody-coated nanoparticles. J Neuropathol Exp Neurol 70(8):653\u2013661","journal-title":"J Neuropathol Exp Neurol"},{"issue":"12","key":"4917_CR109","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.2174\/138920112803341851","volume":"13","author":"W Lu","year":"2012","unstructured":"Lu W (2012) Adsorptive-mediated brain delivery systems. Curr Pharm Biotechnol 13(12):2340\u20132348","journal-title":"Curr Pharm Biotechnol"},{"key":"4917_CR110","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1208\/ps040426","volume":"4","author":"G Drin","year":"2002","unstructured":"Drin G, Rousselle C, Scherrmann JM, Rees AR, Temsamani J (2002) Peptide delivery to the brain via adsorptive-mediated endocytosis: advances with SynB vectors. AAPS PharmSci 4:61\u201367","journal-title":"AAPS PharmSci"},{"issue":"11","key":"4917_CR111","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1038\/jcbfm.2012.126","volume":"32","author":"WM Pardridge","year":"2012","unstructured":"Pardridge WM (2012) Drug transport across the blood\u2013brain barrier. J Cereb Blood Flow Metab 32(11):1959\u20131972","journal-title":"J Cereb Blood Flow Metab"},{"issue":"17","key":"4917_CR112","doi-asserted-by":"publisher","first-page":"4690","DOI":"10.1039\/C6CS00076B","volume":"45","author":"B Oller-Salvia","year":"2016","unstructured":"Oller-Salvia B, S\u00e1nchez-Navarro M, Giralt E, Teixid\u00f3 M (2016) Blood\u2013brain barrier shuttle peptides: an emerging paradigm for brain delivery. Chem Soc Rev 45(17):4690\u20134707","journal-title":"Chem Soc Rev"},{"issue":"3","key":"4917_CR113","doi-asserted-by":"publisher","first-page":"e32616","DOI":"10.1371\/journal.pone.0032616","volume":"7","author":"A Mathew","year":"2012","unstructured":"Mathew A, Fukuda T, Nagaoka Y, Hasumura T, Morimoto H, Yoshida Y, Maekawa T, Venugopal K et al (2012) Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer\u2019s disease. PLoS One 7(3):e32616","journal-title":"PLoS One"},{"key":"4917_CR114","doi-asserted-by":"crossref","unstructured":"Bhatt PC, Verma A, Al-Abbasi FA, Anwar F, Kumar V, Panda BP (2017) Development of surface-engineered PLGA nanoparticulate-delivery system of Tet1-conjugated nattokinase enzyme for inhibition of A\u03b240 plaques in Alzheimer\u2019s disease. Int J Nanomed 8749-68","DOI":"10.2147\/IJN.S144545"},{"issue":"46","key":"4917_CR115","doi-asserted-by":"publisher","first-page":"81001","DOI":"10.18632\/oncotarget.20944","volume":"8","author":"N Huang","year":"2017","unstructured":"Huang N, Lu S, Liu XG, Zhu J, Wang YJ, Liu RT (2017) PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering A\u03b2 generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer\u2019s disease mice. Oncotarget 8(46):81001","journal-title":"Oncotarget"},{"issue":"1","key":"4917_CR116","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijpharm.2006.10.021","volume":"331","author":"J Kreuter","year":"2007","unstructured":"Kreuter J (2007) Nanoparticles\u2014a historical perspective. Int J Pharm 331(1):1","journal-title":"Int J Pharm"},{"key":"4917_CR117","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-018-0356-z","volume":"16","author":"E S\u00e1nchez-L\u00f3pez","year":"2018","unstructured":"S\u00e1nchez-L\u00f3pez E, Ettcheto M, Egea MA, Espina M, Cano A, Calpena AC, Camins A, Carmona N et al (2018) Memantine loaded PLGA PEGylated nanoparticles for Alzheimer\u2019s disease: in vitro and in vivo characterization. J Nanobiotechnol 16:1\u20136","journal-title":"J Nanobiotechnol"},{"issue":"1","key":"4917_CR118","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.ejps.2012.04.013","volume":"47","author":"M Fazil","year":"2012","unstructured":"Fazil M, Shadab MD, Haque S, Kumar M, Baboota S, Kaur Sahni J, Ali J (2012) Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting. Eur J Pharm Sci 47(1):6\u201315","journal-title":"Eur J Pharm Sci"},{"key":"4917_CR119","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1208\/s12249-010-9563-0","volume":"12","author":"S Das","year":"2011","unstructured":"Das S, Chaudhury A (2011) Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. AAPS PharmSciTech 12:62\u201376","journal-title":"AAPS PharmSciTech"},{"issue":"3","key":"4917_CR120","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.cocis.2010.12.005","volume":"16","author":"L Plapied","year":"2011","unstructured":"Plapied L, Duhem N, des Rieux A, Pr\u00e9at V (2011) Fate of polymeric nanocarriers for oral drug delivery. Curr Opin Colloid Interface Sci 16(3):228\u201337","journal-title":"Curr Opin Colloid Interface Sci"},{"issue":"3","key":"4917_CR121","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jconrel.2008.05.010","volume":"132","author":"F Kratz","year":"2008","unstructured":"Kratz F (2008) Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. J Control Release 132(3):171\u2013183","journal-title":"J Control Release"},{"issue":"7","key":"4917_CR122","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1021\/mp2005388","volume":"9","author":"E Roger","year":"2012","unstructured":"Roger E, Kalscheuer S, Kirtane A, Guru BR, Grill AE, Whittum-Hudson J, Panyam J (2012) Folic acid functionalized nanoparticles for enhanced oral drug delivery. Mol Pharm 9(7):2103\u20132110","journal-title":"Mol Pharm"},{"issue":"1","key":"4917_CR123","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/jac\/49.1.155","volume":"49","author":"E Cohen","year":"2002","unstructured":"Cohen E, Dadashev A, Drucker M, Samra Z, Rubinstein E, Garty M (2002) Once\u2013daily versus twice\u2013daily intravenous administration of vancomycin for infections in hospitalized patients. J Antimicrob Chemother 49(1):155\u2013160","journal-title":"J Antimicrob Chemother"},{"key":"4917_CR124","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3389\/fnagi.2019.00373","volume":"11","author":"WM Pardridge","year":"2020","unstructured":"Pardridge WM (2020) Blood-brain barrier and delivery of protein and gene therapeutics to brain. Front Aging Neurosci 11:373","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"4917_CR125","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","volume":"20","author":"MJ Mitchell","year":"2021","unstructured":"Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R (2021) Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discovery 20(2):101\u2013124","journal-title":"Nat Rev Drug Discovery"},{"issue":"9","key":"4917_CR126","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.2174\/1568026614666140329230311","volume":"14","author":"MJ Larsen","year":"2014","unstructured":"Larsen MJ, Martin RD, Byrne EM (2014) Recent advances in delivery through the blood-brain barrier. Curr Topics Med Chem 14(9):1148\u201360","journal-title":"Curr Topics Med Chem"},{"key":"4917_CR127","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.ejps.2016.05.012","volume":"92","author":"E Muntimadugu","year":"2016","unstructured":"Muntimadugu E, Dhommati R, Jain A, Challa VG, Shaheen M, Khan W (2016) Intranasal delivery of nanoparticle encapsulated tarenflurbil: a potential brain targeting strategy for Alzheimer\u2019s disease. Eur J Pharm Sci 92:224\u2013234","journal-title":"Eur J Pharm Sci"},{"issue":"4","key":"4917_CR128","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1080\/17425247.2018.1429401","volume":"15","author":"L Battaglia","year":"2018","unstructured":"Battaglia L, Panciani PP, Muntoni E, Capucchio MT, Biasibetti E, De Bonis P, Mioletti S, Fontanella M et al (2018) Lipid nanoparticles for intranasal administration: application to nose-to-brain delivery. Expert Opin Drug Deliv 15(4):369\u2013378","journal-title":"Expert Opin Drug Deliv"},{"key":"4917_CR129","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.jconrel.2018.05.011","volume":"281","author":"M Agrawal","year":"2018","unstructured":"Agrawal M, Saraf S, Saraf S, Antimisiaris SG, Chougule MB, Shoyele SA, Alexander A (2018) Nose-to-brain drug delivery: an update on clinical challenges and progress towards approval of anti-Alzheimer drugs. J Control Release 281:139\u2013177","journal-title":"J Control Release"},{"key":"4917_CR130","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.jconrel.2017.09.001","volume":"268","author":"AR Khan","year":"2017","unstructured":"Khan AR, Liu M, Khan MW, Zhai G (2017) Progress in brain targeting drug delivery system by nasal route. J Control Release 268:364\u2013389","journal-title":"J Control Release"},{"issue":"12","key":"4917_CR131","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/j.jsps.2022.10.004","volume":"30","author":"HA Alhazmi","year":"2022","unstructured":"Alhazmi HA, Albratty M (2022) An update on the novel and approved drugs for Alzheimer disease. Saudi Pharm J 30(12):1755\u20131764","journal-title":"Saudi Pharm J"},{"key":"4917_CR132","first-page":"100039","volume":"4","author":"R Ali","year":"2022","unstructured":"Ali R, Gupta GD, Chawla PA (2022) Aducanumab: a new hope in Alzheimer\u2019s disease. Health Sci Rev 4:100039","journal-title":"Health Sci Rev"},{"issue":"1","key":"4917_CR133","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12929-023-00976-6","volume":"30","author":"LK Huang","year":"2023","unstructured":"Huang LK, Kuan YC, Lin HW, Hu CJ (2023) Clinical trials of new drugs for Alzheimer disease: a 2020\u20132023 update. J Biomed Sci 30(1):83","journal-title":"J Biomed Sci"},{"issue":"1","key":"4917_CR134","doi-asserted-by":"publisher","first-page":"e12295","DOI":"10.1002\/trc2.12295","volume":"8","author":"J Cummings","year":"2022","unstructured":"Cummings J, Lee G, Nahed P, Kambar ME, Zhong K, Fonseca J, Taghva K (2022) Alzheimer\u2019s disease drug development pipeline: 2022. Alzheimer\u2019s Dement Transl Res Clin Interv 8(1):e12295","journal-title":"Alzheimer\u2019s Dement Transl Res Clin Interv"},{"key":"4917_CR135","doi-asserted-by":"crossref","unstructured":"Singh S, Mahajan M, Kumar D, Singh K, Chowdhary M (2023) An inclusive study of recent advancements in Alzheimer\u2019s disease: a comprehensive review. Neuropeptides 102369","DOI":"10.1016\/j.npep.2023.102369"},{"issue":"36","key":"4917_CR136","doi-asserted-by":"publisher","first-page":"e34982","DOI":"10.1097\/MD.0000000000034982","volume":"102","author":"X Yang","year":"2023","unstructured":"Yang X, Qu H (2023) Bibliometric review on biomarkers for Alzheimer\u2019s disease between 2000 and 2023. Medicine 102(36):e34982","journal-title":"Medicine"},{"key":"4917_CR137","doi-asserted-by":"crossref","unstructured":"Al Noman A, Afrosa H, Lihu IK, Sarkar O, Nabin NR, Datta M, Pathak R, Sharma H (2024) Vitamin D and neurological health: Unraveling risk factors, disease progression, and treatment potential. CNS Neurol Disord-Drug Targets","DOI":"10.2174\/0118715273330972241009092828"},{"key":"4917_CR138","doi-asserted-by":"crossref","unstructured":"Sarkar S, Bhui U, Kumar B, Ashique S, Kumar P, Sharma H, Bhowmick M, Pal R et al (2024) Correlation between cognitive impairment and peripheral biomarkers-significance of phosphorylated tau and amyloid-\u03b2 in Alzheimer\u2019s disease: a new insight. Curr Psychiatry Res Rev","DOI":"10.2174\/0126660822329981241007105405"},{"issue":"7","key":"4917_CR139","doi-asserted-by":"publisher","first-page":"7","DOI":"10.53879\/id.61.07.14382","volume":"61","author":"P Chandra","year":"2024","unstructured":"Chandra P, Sharma H (2024) Phosphodiesterase inhibitors for treatment of Alzheimer\u2019s disease. Indian Drugs 61(7):7\u201322","journal-title":"Indian Drugs"},{"key":"4917_CR140","doi-asserted-by":"crossref","unstructured":"Halagali P, Nayak D, Tippavajhala VK, Rathnanand M, Biswas D, Sharma H (2025) Navigating the nanoscopic frontier: ethical dimensions in developing nanocarriers for neurodegenerative diseases. InThe Neurodegeneration Revolution (pp. 399\u2013420). Academic Press.","DOI":"10.1016\/B978-0-443-28822-7.00011-8"},{"key":"4917_CR141","doi-asserted-by":"crossref","unstructured":"Halagali P, Nayak D, Rathnanand M, Tippavajhala VK, Sharma H, Biswas D (2025) Synergizing sustainable green nanotechnology and AI\/ML for advanced nanocarriers: a paradigm shift in the treatment of neurodegenerative diseases. InThe Neurodegeneration Revolution (pp. 373\u2013397). Academic Press.","DOI":"10.1016\/B978-0-443-28822-7.00017-9"},{"key":"4917_CR142","doi-asserted-by":"crossref","unstructured":"Sharma H, Rachamalla HK, Mishra N, Chandra P, Pathak R, Ashique S (2024) Introduction to exosome and its role in brain disorders. Exosomes Based Drug Deliv Strateg Brain Disord 1-35","DOI":"10.1007\/978-981-99-8373-5_1"},{"key":"4917_CR143","doi-asserted-by":"crossref","unstructured":"Sharma H, Tyagi SJ, Chandra P, Verma A, Kumar P, Ashique S, Hussain A (2024) Role of exosomes in Parkinson\u2019s and Alzheimer\u2019s diseases. InExosomes Based Drug Delivery Strategies for Brain Disorders (pp. 147\u2013182). Singapore: Springer Nature Singapore.","DOI":"10.1007\/978-981-99-8373-5_6"},{"key":"4917_CR144","doi-asserted-by":"crossref","unstructured":"Kumar P, Sharma H, Singh A, Pandey SN, Chandra P (2024) Correlation between exosomes and neuro-inflammation in various brain disorders. InExosomes Based Drug Delivery Strategies for Brain Disorders (pp. 273\u2013302). Singapore: Springer Nature Singapore.","DOI":"10.1007\/978-981-99-8373-5_11"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-04917-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-04917-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-04917-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T12:13:07Z","timestamp":1757160787000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-04917-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,16]]},"references-count":144,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["4917"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-04917-2","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,16]]},"assertion":[{"value":"1 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}