{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:50:47Z","timestamp":1773183047611,"version":"3.50.1"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Imaging Medical Star Technology Project of Suzhou Medical Association","award":["2023YX-M03"],"award-info":[{"award-number":["2023YX-M03"]}]},{"name":"Suzhou Ninth People's Hospital Project","award":["YK202114"],"award-info":[{"award-number":["YK202114"]}]},{"name":"Jiangsu Province Capability Improvement Project through Science, Technology and Education","award":["JSDW202242"],"award-info":[{"award-number":["JSDW202242"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s12035-025-04951-0","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T08:24:55Z","timestamp":1745483095000},"page":"11253-11267","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Topological Reorganization and Resting-State Functional Connectivity in Functional Dyspepsia: Associations of Symptoms with Peripheral Cytokine Levels and Amygdala Nodal Centrality"],"prefix":"10.1007","volume":"62","author":[{"given":"Jing","family":"Chi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiding","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"issue":"11","key":"4951_CR1","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1111\/nmo.12227","volume":"25","author":"H Vanheel","year":"2013","unstructured":"Vanheel H, Vanuytsel T, Van Oudenhove L et al (2013) Postprandial symptoms originating from the stomach in functional dyspepsia. Neurogastroenterol Motil 25(11):911-e703. https:\/\/doi.org\/10.1111\/nmo.12227","journal-title":"Neurogastroenterol Motil"},{"issue":"10263","key":"4951_CR2","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1016\/s0140-6736(20)30469-4","volume":"396","author":"AC Ford","year":"2020","unstructured":"Ford AC, Mahadeva S, Carbone MF et al (2020) Functional dyspepsia. The Lancet 396(10263):1689\u20131702. https:\/\/doi.org\/10.1016\/s0140-6736(20)30469-4","journal-title":"The Lancet"},{"issue":"11","key":"4951_CR3","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1111\/j.1365-2036.2011.04640.x","volume":"33","author":"P Aro","year":"2011","unstructured":"Aro P, Talley NJ, Agreus L et al (2011) Functional dyspepsia impairs quality of life in the adult population. Aliment Pharmacol Ther 33(11):1215\u20131224. https:\/\/doi.org\/10.1111\/j.1365-2036.2011.04640.x","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"4951_CR4","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00535-021-01843-7","volume":"57","author":"M Hiroto","year":"2022","unstructured":"Hiroto M, Akihito N, Akihiro A et al (2022) Evidence-based clinical practice guidelines for functional dyspepsia 2021. J Gastroenterol 57(2):47\u201361. https:\/\/doi.org\/10.1007\/s00535-021-01843-7","journal-title":"J Gastroenterol"},{"issue":"7","key":"4951_CR5","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1136\/gut.2005.078634","volume":"55","author":"NJ Talley","year":"2006","unstructured":"Talley NJ, Locke GR, Lahr BD et al (2006) Functional dyspepsia, delayed gastric emptying, and impaired quality of life. Gut 55(7):933\u2013939. https:\/\/doi.org\/10.1136\/gut.2005.078634","journal-title":"Gut"},{"issue":"9","key":"4951_CR6","doi-asserted-by":"publisher","first-page":"e14238","DOI":"10.1002\/ueg2.12061","volume":"33","author":"L Wauters","year":"2021","unstructured":"Wauters L, Dickman R, Drug V et al (2021) United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia. Neurogastroenterol Motil 33(9):e14238. https:\/\/doi.org\/10.1002\/ueg2.12061","journal-title":"Neurogastroenterol Motil"},{"issue":"6","key":"4951_CR7","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1111\/nmo.12793","volume":"28","author":"I-S Lee","year":"2016","unstructured":"Lee I-S, Wang H, Chae Y et al (2016) Functional neuroimaging studies in functional dyspepsia patients: a systematic review. Neurogastroenterol Motil 28(6):793\u2013805. https:\/\/doi.org\/10.1111\/nmo.12793","journal-title":"Neurogastroenterol Motil"},{"issue":"2","key":"4951_CR8","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1053\/j.gastro.2011.05.003","volume":"141","author":"F Zeng","year":"2011","unstructured":"Zeng F, Qin W, Liang F et al (2011) Abnormal resting brain activity in patients with functional dyspepsia is related to symptom severity. Gastroenterology 141(2):499\u2013506. https:\/\/doi.org\/10.1053\/j.gastro.2011.05.003","journal-title":"Gastroenterology"},{"issue":"1","key":"4951_CR9","doi-asserted-by":"publisher","first-page":"103","DOI":"10.5056\/jnm14096","volume":"21","author":"J Nan","year":"2015","unstructured":"Nan J, Liu J, Mu J et al (2015) Brain-based correlations between psychological factors and functional dyspepsia. J Neurogastroenterol Motil 21(1):103. https:\/\/doi.org\/10.5056\/jnm14096","journal-title":"J Neurogastroenterol Motil"},{"issue":"1","key":"4951_CR10","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1053\/j.gastro.2005.04.012","volume":"129","author":"F Mearin","year":"2005","unstructured":"Mearin F, P\u00e9rez-Oliveras M, Perell\u00f3 A et al (2005) Dyspepsia and irritable bowel syndrome after a Salmonella gastroenteritis outbreak: one-year follow-up cohort study. Gastroenterology 129(1):98\u2013104. https:\/\/doi.org\/10.1053\/j.gastro.2005.04.012","journal-title":"Gastroenterology"},{"issue":"3","key":"4951_CR11","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1053\/j.gastro.2007.01.046","volume":"132","author":"T Liebregts","year":"2007","unstructured":"Liebregts T, Adam B, Bredack C et al (2007) Immune activation in patients with irritable bowel syndrome. Gastroenterology 132(3):913\u2013920. https:\/\/doi.org\/10.1053\/j.gastro.2007.01.046","journal-title":"Gastroenterology"},{"key":"4951_CR12","doi-asserted-by":"publisher","unstructured":"Vara EJ, Brokstad KA, Hausken T et al (2018) Altered levels of cytokines in patients with irritable bowel syndrome are not correlated with fatigue. Int J Gen Med :285\u2013291. https:\/\/doi.org\/10.2147\/IJGM.S166600","DOI":"10.2147\/IJGM.S166600"},{"key":"4951_CR13","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.cyto.2017.05.005","volume":"93","author":"R Choghakhori","year":"2017","unstructured":"Choghakhori R, Abbasnezhad A, Hasanvand A et al (2017) Inflammatory cytokines and oxidative stress biomarkers in irritable bowel syndrome: association with digestive symptoms and quality of life. Cytokine 93:34\u201343. https:\/\/doi.org\/10.1016\/j.cyto.2017.05.005","journal-title":"Cytokine"},{"issue":"4","key":"4951_CR14","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/j.1365-2982.2008.01220.x","volume":"21","author":"S Kindt","year":"2009","unstructured":"Kindt S, Van Oudenhove L, Broekaert D et al (2009) Immune dysfunction in patients with functional gastrointestinal disorders. Neurogastroenterol Motil 21(4):389\u2013398. https:\/\/doi.org\/10.1111\/j.1365-2982.2008.01220.x","journal-title":"Neurogastroenterol Motil"},{"issue":"6","key":"4951_CR15","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/ajg.2010.512","volume":"106","author":"T Liebregts","year":"2011","unstructured":"Liebregts T, Adam B, Bredack C et al (2011) Small bowel homing T cells are associated with symptoms and delayed gastric emptying in functional dyspepsia. Off J Am Coll Gastroenterol | ACG 106(6):1089\u20131098. https:\/\/doi.org\/10.1038\/ajg.2010.512","journal-title":"Off J Am Coll Gastroenterol | ACG"},{"issue":"2","key":"4951_CR16","doi-asserted-by":"publisher","first-page":"AB65","DOI":"10.1016\/j.jaci.2012.12.896","volume":"131","author":"M Mortezavi","year":"2013","unstructured":"Mortezavi M, Keeling PWN, Quigley Eamonn MM et al (2013) Elevated interleukin-6 levels in irritable bowel syndrome and non-ulcerative dyspepsia. J Allergy Clin Immunol 131(2):AB65. https:\/\/doi.org\/10.1016\/j.jaci.2012.12.896","journal-title":"J Allergy Clin Immunol"},{"key":"4951_CR17","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.bbi.2015.03.017","volume":"48","author":"B Sven","year":"2015","unstructured":"Sven B, Laura R, Alexander W et al (2015) Neural circuitry mediating inflammation-induced central pain amplification in human experimental endotoxemia. Brain Behav Immun 48:222\u2013231. https:\/\/doi.org\/10.1016\/j.bbi.2015.03.017","journal-title":"Brain Behav Immun"},{"key":"4951_CR18","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.bbi.2016.04.001","volume":"57","author":"K Bianka","year":"2016","unstructured":"Bianka K, Jensen KB, Kosek E et al (2016) Why sickness hurts: a central mechanism for pain induced by peripheral inflammation. Brain Behav Immun 57:38\u201346. https:\/\/doi.org\/10.1016\/j.bbi.2016.04.001","journal-title":"Brain Behav Immun"},{"key":"4951_CR19","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.bbi.2020.11.035","volume":"92","author":"N Anna-Karin","year":"2021","unstructured":"Anna-Karin N, Susanna W, Adriane I et al (2021) Fatigue in irritable bowel syndrome is associated with plasma levels of TNF-\u03b1 and mesocorticolimbic connectivity. Brain Behav Immun 92:211\u2013220. https:\/\/doi.org\/10.1016\/j.bbi.2020.11.035","journal-title":"Brain Behav Immun"},{"key":"4951_CR20","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.bbi.2019.06.010","volume":"81","author":"G Nina","year":"2019","unstructured":"Nina G, Fors Egil A, Kl\u00e6bo RS (2019) Patients with fibromyalgia and chronic fatigue syndrome show increased hsCRP compared to healthy controls. Brain Behav Immun 81:172\u2013177. https:\/\/doi.org\/10.1016\/j.bbi.2019.06.010","journal-title":"Brain Behav Immun"},{"issue":"2","key":"4951_CR21","doi-asserted-by":"publisher","first-page":"268","DOI":"10.5056\/jnm17076","volume":"24","author":"Y Chen","year":"2018","unstructured":"Chen Y, Wang R, Hou B et al (2018) Regional brain activity during rest and gastric water load in subtypes of functional dyspepsia: a preliminary brain functional magnetic resonance imaging study. J Neurogastroenterol Motil 24(2):268. https:\/\/doi.org\/10.5056\/jnm17076","journal-title":"J Neurogastroenterol Motil"},{"key":"4951_CR22","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1146\/annurev-clinpsy-040510-143934","volume":"7","author":"ET Bullmore","year":"2011","unstructured":"Bullmore ET, Bassett DS (2011) Brain graphs: graphical models of the human brain connectome. Ann Rev Clin Psychol 7:113\u2013140. https:\/\/doi.org\/10.1146\/annurev-clinpsy-040510-143934","journal-title":"Ann Rev Clin Psychol"},{"issue":"6","key":"4951_CR23","doi-asserted-by":"publisher","first-page":"e382","DOI":"10.1111\/nmo.12131","volume":"25","author":"P Liu","year":"2013","unstructured":"Liu P, Zeng F, Zhou G et al (2013) Alterations of the default mode network in functional dyspepsia patients: a resting-state fmri study. Neurogastroenterol Motil 25(6):e382\u2013e388. https:\/\/doi.org\/10.1111\/nmo.12131","journal-title":"Neurogastroenterol Motil"},{"issue":"9","key":"4951_CR24","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1523\/JNEUROSCI.5587-06.2007","volume":"27","author":"WW Seeley","year":"2007","unstructured":"Seeley WW, Menon V, Schatzberg AF et al (2007) Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci 27(9):2349\u20132356. https:\/\/doi.org\/10.1523\/JNEUROSCI.5587-06.2007","journal-title":"J Neurosci"},{"issue":"6","key":"4951_CR25","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1053\/j.gastro.2016.02.032","volume":"150","author":"DA Drossman","year":"2016","unstructured":"Drossman DA (2016) Functional gastrointestinal disorders: history, pathophysiology, clinical features, and Rome IV. Gastroenterology 150(6):1262-1279.e1262. https:\/\/doi.org\/10.1053\/j.gastro.2016.02.032","journal-title":"Gastroenterology"},{"key":"4951_CR26","doi-asserted-by":"publisher","unstructured":"Cockrell JR, Folstein MF (2002) Mini-mental state examination. Princ Pract Geriatr Psychiatr :140\u2013141. https:\/\/doi.org\/10.1002\/0470846410","DOI":"10.1002\/0470846410"},{"issue":"4","key":"4951_CR27","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","volume":"53","author":"ZS Nasreddine","year":"2005","unstructured":"Nasreddine ZS, Phillips NA, B\u00e9dirian V et al (2005) The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53(4):695\u2013699. https:\/\/doi.org\/10.1111\/j.1532-5415.2005.53221.x","journal-title":"J Am Geriatr Soc"},{"key":"4951_CR28","doi-asserted-by":"publisher","unstructured":"Zung WW (1971) A rating instrument for anxiety disorders. Psychosom: J Consult Liaison Psychiatry. https:\/\/doi.org\/10.1016\/S0033-3182(71)71479-0","DOI":"10.1016\/S0033-3182(71)71479-0"},{"issue":"6","key":"4951_CR29","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1001\/archpsyc.1965.01730060026004","volume":"13","author":"WW Zung","year":"1965","unstructured":"Zung WW, Richards CB, Short MJ (1965) Self-rating depression scale in an outpatient clinic: further validation of the SDS. Arch Gen Psychiatry 13(6):508\u2013515. https:\/\/doi.org\/10.1001\/archpsyc.1965.01730060026004","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"4951_CR30","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1046\/j.1365-2036.2001.00900.x","volume":"15","author":"NJ Talley","year":"2001","unstructured":"Talley NJ, Verlinden M, Jones M (2001) Quality of life in functional dyspepsia: responsiveness of the Nepean Dyspepsia Index and development of a new 10-item short form. Aliment Pharmacol Ther 15(2):207\u2013216. https:\/\/doi.org\/10.1046\/j.1365-2036.2001.00900.x","journal-title":"Aliment Pharmacol Ther"},{"issue":"9","key":"4951_CR31","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1111\/j.1572-0241.1999.01363.x","volume":"94","author":"NJ Talley","year":"1999","unstructured":"Talley NJ, Verlinden M, Jones M (1999) Validity of a new quality of life scale for functional dyspepsia: a United States multicenter trial of the Nepean Dyspepsia Index. Off J Am Coll Gastroenterol | ACG 94(9):2390\u20132397. https:\/\/doi.org\/10.1111\/j.1572-0241.1999.01363.x","journal-title":"Off J Am Coll Gastroenterol | ACG"},{"issue":"4","key":"4951_CR32","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/j.1365-2036.2005.02572.x","volume":"22","author":"B Adam","year":"2005","unstructured":"Adam B, Liebregts T, Saadat-Gilani K et al (2005) Validation of the gastrointestinal symptom score for the assessment of symptoms in patients with functional dyspepsia. Aliment Pharmacol Ther 22(4):357\u2013363. https:\/\/doi.org\/10.1111\/j.1365-2036.2005.02572.x","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"4951_CR33","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","volume":"38","author":"J Ashburner","year":"2007","unstructured":"Ashburner J (2007) A fast diffeomorphic image registration algorithm. Neuroimage 38(1):95\u2013113. https:\/\/doi.org\/10.1016\/j.neuroimage.2007.07.007","journal-title":"Neuroimage"},{"issue":"1","key":"4951_CR34","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/nimg.2001.0978","volume":"15","author":"N Tzourio-Mazoyer","year":"2002","unstructured":"Tzourio-Mazoyer N, Landeau B, Papathanassiou D et al (2002) Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15(1):273\u2013289. https:\/\/doi.org\/10.1006\/nimg.2001.0978","journal-title":"Neuroimage"},{"issue":"3","key":"4951_CR35","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","volume":"52","author":"M Rubinov","year":"2010","unstructured":"Rubinov M, Sporns O (2010) Complex network measures of brain connectivity: uses and interpretations. Neuroimage 52(3):1059\u20131069. https:\/\/doi.org\/10.1016\/j.neuroimage.2009.10.003","journal-title":"Neuroimage"},{"issue":"6","key":"4951_CR36","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1002\/hbm.21079","volume":"32","author":"JS Anderson","year":"2011","unstructured":"Anderson JS, Druzgal TJ, Lopez-Larson M et al (2011) Network anticorrelations, global regression, and phase-shifted soft tissue correction. Human Brain Mapp 32(6):919\u2013934. https:\/\/doi.org\/10.1002\/hbm.21079","journal-title":"Human Brain Mapp"},{"issue":"4","key":"4951_CR37","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/j.neuroimage.2009.05.012","volume":"47","author":"C Chang","year":"2009","unstructured":"Chang C, Glover GH (2009) Effects of model-based physiological noise correction on default mode network anti-correlations and correlations. Neuroimage 47(4):1448\u20131459. https:\/\/doi.org\/10.1016\/j.neuroimage.2009.05.012","journal-title":"Neuroimage"},{"key":"4951_CR38","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.neubiorev.2017.03.018","volume":"77","author":"X Liao","year":"2017","unstructured":"Liao X, Vasilakos AV, He Y (2017) Small-world human brain networks: perspectives and challenges. Neurosci Biobehav Rev 77:286\u2013300. https:\/\/doi.org\/10.1016\/j.neubiorev.2017.03.018","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"4951_CR39","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1002\/hbm.22185","volume":"35","author":"H Li","year":"2014","unstructured":"Li H, Xue Z, Ellmore TM et al (2014) Network-based analysis reveals stronger local diffusion-based connectivity and different correlations with oral language skills in brains of children with high functioning autism spectrum disorders. Hum Brain Mapp 35(2):396\u2013413. https:\/\/doi.org\/10.1002\/hbm.22185","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"4951_CR40","doi-asserted-by":"publisher","first-page":"118","DOI":"10.5056\/jnm15118","volume":"22","author":"J Nan","year":"2016","unstructured":"Nan J, Zhang L, Zhu F et al (2016) Topological alterations of the intrinsic brain network in patients with functional dyspepsia. J Neurogastroenterol Motil 22(1):118. https:\/\/doi.org\/10.5056\/jnm15118","journal-title":"J Neurogastroenterol Motil"},{"key":"4951_CR41","doi-asserted-by":"publisher","first-page":"1001557","DOI":"10.3389\/fnmol.2022.1001557","volume":"15","author":"P Zhang","year":"2022","unstructured":"Zhang P, He Z, Mao Y et al (2022) Aberrant resting-state functional connectivity and topological properties of the subcortical network in functional dyspepsia patients. Front Mol Neurosci 15:1001557. https:\/\/doi.org\/10.3389\/fnmol.2022.1001557","journal-title":"Front Mol Neurosci"},{"issue":"3","key":"4951_CR42","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/nrn2575","volume":"10","author":"E Bullmore","year":"2009","unstructured":"Bullmore E, Sporns O (2009) Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 10(3):186\u2013198. https:\/\/doi.org\/10.1038\/nrn2575","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"4951_CR43","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1053\/j.gastro.2016.02.018","volume":"150","author":"SJ Vanner","year":"2016","unstructured":"Vanner SJ, Greenwood-Van Meerveld B, Mawe GM et al (2016) Fundamentals of neurogastroenterology: basic science. Gastroenterology 150(6):1280\u20131291. https:\/\/doi.org\/10.1053\/j.gastro.2016.02.018","journal-title":"Gastroenterology"},{"issue":"4","key":"4951_CR44","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/ajg.2010.39","volume":"105","author":"L Van Oudenhove","year":"2010","unstructured":"Van Oudenhove L, Vandenberghe J, Dupont P et al (2010) Abnormal regional brain activity during rest and (anticipated) gastric distension in functional dyspepsia and the role of anxiety: a H215O-PET study. Off J Am Coll Gastroenterol ACG 105(4):913\u2013924. https:\/\/doi.org\/10.1038\/ajg.2010.39","journal-title":"Off J Am Coll Gastroenterol ACG"},{"key":"4951_CR45","doi-asserted-by":"publisher","first-page":"S50","DOI":"10.1097\/j.pain.0000000000000106","volume":"156","author":"EA Mayer","year":"2015","unstructured":"Mayer EA, Gupta A, Kilpatrick LA et al (2015) Imaging brain mechanisms in chronic visceral pain. Pain 156:S50\u2013S63. https:\/\/doi.org\/10.1097\/j.pain.0000000000000106","journal-title":"Pain"},{"issue":"1","key":"4951_CR46","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/j.1749-6632.2003.tb07081.x","volume":"985","author":"LW Swanson","year":"2003","unstructured":"Swanson LW (2003) The amygdala and its place in the cerebral hemisphere. Ann NY Acad Sci 985(1):174\u2013184. https:\/\/doi.org\/10.1111\/j.1749-6632.2003.tb07081.x","journal-title":"Ann NY Acad Sci"},{"issue":"20","key":"4951_CR47","doi-asserted-by":"publisher","first-page":"7964","DOI":"10.1523\/jneurosci.3884-14.2015","volume":"35","author":"X Sun","year":"2015","unstructured":"Sun X, Kroemer NB, Veldhuizen MG et al (2015) Basolateral amygdala response to food cues in the absence of hunger is associated with weight gain susceptibility. J Neurosci 35(20):7964\u20137976. https:\/\/doi.org\/10.1523\/jneurosci.3884-14.2015","journal-title":"J Neurosci"},{"issue":"3","key":"4951_CR48","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.bbrc.2003.11.150","volume":"313","author":"VP Carlini","year":"2004","unstructured":"Carlini VP, Varas MM, Cragnolini AB et al (2004) Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin. Biochem Biophys Res Commun 313(3):635\u2013641. https:\/\/doi.org\/10.1016\/j.bbrc.2003.11.150","journal-title":"Biochem Biophys Res Commun"},{"key":"4951_CR49","doi-asserted-by":"publisher","first-page":"559","DOI":"10.3389\/fnhum.2017.00559","volume":"11","author":"C Bao","year":"2017","unstructured":"Bao C, Wang D, Liu P et al (2017) Effect of electro-acupuncture and moxibustion on brain connectivity in patients with Crohn\u2019s disease: a resting-state fMRI study. Front Hum Neurosci 11:559. https:\/\/doi.org\/10.3389\/fnhum.2017.00559","journal-title":"Front Hum Neurosci"},{"issue":"1","key":"4951_CR50","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s11682-019-00249-7","volume":"15","author":"S Ruirui","year":"2021","unstructured":"Ruirui S, Zhaoxuan He, Peihong Ma et al (2021) The participation of basolateral amygdala in the efficacy of acupuncture with deqi treating for functional dyspepsia. Brain Imaging Behav 15(1):216\u2013230. https:\/\/doi.org\/10.1007\/s11682-019-00249-7","journal-title":"Brain Imaging Behav"},{"issue":"50","key":"4951_CR51","doi-asserted-by":"publisher","first-page":"20254","DOI":"10.1073\/pnas.1112029108","volume":"108","author":"JA Brewer","year":"2011","unstructured":"Brewer JA, Worhunsky PD, Gray JR et al (2011) Meditation experience is associated with differences in default mode network activity and connectivity. Proc Natl Acad Sci 108(50):20254\u201320259. https:\/\/doi.org\/10.1073\/pnas.1112029108","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"4951_CR52","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1148\/radiol.2016151771","volume":"129","author":"E Cavanna Andrea","year":"2006","unstructured":"Cavanna Andrea E, Trimble Michael R (2006) The precuneus: a review of its functional anatomy and behavioural correlates. Brain 129(3):564\u2013583. https:\/\/doi.org\/10.1148\/radiol.2016151771","journal-title":"Brain"},{"issue":"2","key":"4951_CR53","doi-asserted-by":"publisher","first-page":"e0116640","DOI":"10.1371\/journal.pone.0116640","volume":"10","author":"JJ Tuulari","year":"2015","unstructured":"Tuulari JJ, Karlsson HK, Hirvonen J et al (2015) Neural circuits for cognitive appetite control in healthy and obese individuals: an fMRI study. PloS one 10(2):e0116640. https:\/\/doi.org\/10.1371\/journal.pone.0116640","journal-title":"PloS one"},{"issue":"4","key":"4951_CR54","doi-asserted-by":"publisher","first-page":"781","DOI":"10.3945\/ajcn.116.141143","volume":"105","author":"SR Winter","year":"2017","unstructured":"Winter SR, Yokum S, Stice E et al (2017) Elevated reward response to receipt of palatable food predicts future weight variability in healthy-weight adolescents. Am J Clin Nutr 105(4):781\u2013789. https:\/\/doi.org\/10.3945\/ajcn.116.141143","journal-title":"Am J Clin Nutr"},{"issue":"12","key":"4951_CR55","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1038\/ijo.2013.39","volume":"37","author":"S Yokum","year":"2013","unstructured":"Yokum S, Stice E (2013) Cognitive regulation of food craving: effects of three cognitive reappraisal strategies on neural response to palatable foods. Int J Obes 37(12):1565\u20131570. https:\/\/doi.org\/10.1038\/ijo.2013.39","journal-title":"Int J Obes"},{"issue":"24","key":"4951_CR56","doi-asserted-by":"publisher","first-page":"9896","DOI":"10.1523\/jneurosci.21-24-09896.2001","volume":"21","author":"A Ploghaus","year":"2001","unstructured":"Ploghaus A, Narain C, Beckmann CF et al (2001) Exacerbation of pain by anxiety is associated with activity in a hippocampal network. J Neurosci 21(24):9896\u20139903. https:\/\/doi.org\/10.1523\/jneurosci.21-24-09896.2001","journal-title":"J Neurosci"},{"issue":"7","key":"4951_CR57","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nrn1704","volume":"6","author":"BA Vogt","year":"2005","unstructured":"Vogt BA (2005) Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev Neurosci 6(7):533\u2013544. https:\/\/doi.org\/10.1038\/nrn1704","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"4951_CR58","doi-asserted-by":"publisher","first-page":"e65870","DOI":"10.1371\/journal.pone.0065870","volume":"8","author":"J Nan","year":"2013","unstructured":"Nan J, Liu J, Li G et al (2013) Whole-brain functional connectivity identification of functional dyspepsia. PloS one 8(6):e65870. https:\/\/doi.org\/10.1371\/journal.pone.0065870","journal-title":"PloS one"},{"key":"4951_CR59","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s00429-010-0262-0","volume":"214","author":"M Vinod","year":"2010","unstructured":"Vinod M, Uddin Lucina Q (2010) Saliency, switching, attention and control: a network model of insula function. Brain Struct Funct 214:655\u2013667. https:\/\/doi.org\/10.1007\/s00429-010-0262-0","journal-title":"Brain Struct Funct"},{"issue":"8","key":"4951_CR60","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/nrn894","volume":"3","author":"AD Craig","year":"2002","unstructured":"Craig AD (2002) How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci 3(8):655\u2013666. https:\/\/doi.org\/10.1038\/nrn894","journal-title":"Nat Rev Neurosci"},{"issue":"5528","key":"4951_CR61","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1126\/science.1060952","volume":"293","author":"J-K Zubieta","year":"2001","unstructured":"Zubieta J-K, Smith YR, Bueller JA et al (2001) Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science 293(5528):311\u2013315. https:\/\/doi.org\/10.1126\/science.1060952","journal-title":"Science"},{"issue":"25","key":"4951_CR62","doi-asserted-by":"publisher","first-page":"3438","DOI":"10.3748\/wjg.v13.i25.3438","volume":"13","author":"L Van Oudenhove","year":"2007","unstructured":"Van Oudenhove L, Coen SJ, Aziz Q (2007) Functional brain imaging of gastrointestinal sensation in health and disease. World J Gastroenterol: WJG 13(25):3438. https:\/\/doi.org\/10.3748\/wjg.v13.i25.3438","journal-title":"World J Gastroenterol: WJG"},{"issue":"2","key":"4951_CR63","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1053\/j.gastro.2006.05.014","volume":"131","author":"BD Naliboff","year":"2006","unstructured":"Naliboff BD, Berman S, Suyenobu B et al (2006) Longitudinal change in perceptual and brain activation response to visceral stimuli in irritable bowel syndrome patients. Gastroenterology 131(2):352\u2013365. https:\/\/doi.org\/10.1053\/j.gastro.2006.05.014","journal-title":"Gastroenterology"},{"key":"4951_CR64","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.pneurobio.2013.02.003","volume":"104","author":"D Borsook","year":"2013","unstructured":"Borsook D, Edwards R, Elman I et al (2013) Pain and analgesia: the value of salience circuits. Prog Neurobiol 104:93\u2013105. https:\/\/doi.org\/10.1016\/j.pneurobio.2013.02.003","journal-title":"Prog Neurobiol"},{"issue":"10","key":"4951_CR65","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1111\/j.1572-0241.2008.01871.x","volume":"103","author":"TG Dinan","year":"2008","unstructured":"Dinan TG, Clarke G, Quigley EMM et al (2008) Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors. Off J Am Coll Gastroenterol ACG 103(10):2570\u20132576. https:\/\/doi.org\/10.1111\/j.1572-0241.2008.01871.x","journal-title":"Off J Am Coll Gastroenterol ACG"},{"issue":"7","key":"4951_CR66","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1136\/gut.33.7.933","volume":"33","author":"M Nakamura","year":"1992","unstructured":"Nakamura M, Saito H, Kasanuki J et al (1992) Cytokine production in patients with inflammatory bowel disease. Gut 33(7):933\u2013937. https:\/\/doi.org\/10.1136\/gut.33.7.933","journal-title":"Gut"},{"issue":"3","key":"4951_CR67","doi-asserted-by":"publisher","first-page":"G582","DOI":"10.1152\/ajpgi.2000.279.3.g582","volume":"279","author":"GS Emch","year":"2000","unstructured":"Emch GS, Hermann GE, Rogers RC (2000) TNF-\u03b1 activates solitary nucleus neurons responsive to gastric distension. Am J Physiol-Gastrointest Liver Physiol 279(3):G582\u2013G586. https:\/\/doi.org\/10.1152\/ajpgi.2000.279.3.g582","journal-title":"Am J Physiol-Gastrointest Liver Physiol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-04951-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-04951-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-04951-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T04:06:24Z","timestamp":1755662784000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-04951-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,24]]},"references-count":67,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["4951"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-04951-0","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,24]]},"assertion":[{"value":"1 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Suzhou Ninth People's Hospital Affiliated to Soochow University (Date: 2022\u201301-25\/No: 202292).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}