{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:52:41Z","timestamp":1788367961260,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260525"],"award-info":[{"award-number":["82260525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s12035-025-04954-x","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:25:57Z","timestamp":1745450757000},"page":"11268-11285","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Inhibition of FOXD3 O-GlcNAc Modification Ameliorates Spinal Cord Injury by Promoting STUB1-Mediated Ubiquitination Degradation of HMGB1"],"prefix":"10.1007","volume":"62","author":[{"given":"Wu","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Hei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"issue":"1","key":"4954_CR1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.4103\/1673-5374.314322","volume":"17","author":"XM Zhang","year":"2022","unstructured":"Zhang XM, Zeng LN, Yang WY, Ding L, Chen KZ, Fu WJ, Zeng SQ, Liang YR et al (2022) Inhibition of LncRNA Vof-16 expression promotes nerve regeneration and functional recovery after spinal cord injury. Neural Regen Res 17(1):217\u2013227. https:\/\/doi.org\/10.4103\/1673-5374.314322","journal-title":"Neural Regen Res"},{"key":"4954_CR2","doi-asserted-by":"publisher","unstructured":"(2016) Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study. Lancet Neurol 18(1):56\u201387. https:\/\/doi.org\/10.1016\/S1474-4422(18)30415-0","DOI":"10.1016\/S1474-4422(18)30415-0"},{"issue":"7","key":"4954_CR3","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/S1474-4422(21)00464-6","volume":"21","author":"CM Zipser","year":"2022","unstructured":"Zipser CM, Cragg JJ, Guest JD, Fehlings MG, Jutzeler CR, Anderson AJ, Curt A (2022) Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials. Lancet Neurol 21(7):659\u2013670. https:\/\/doi.org\/10.1016\/S1474-4422(21)00464-6","journal-title":"Lancet Neurol"},{"key":"4954_CR4","doi-asserted-by":"publisher","unstructured":"Wang C, Wang M, Xia K, Wang J, Cheng F, Shi K, Ying L, Yu C et al (2021) A bioactive injectable self-healing anti-inflammatory hydrogel with ultralong extracellular vesicles release synergistically enhances motor functional recovery of spinal cord injury. Bioact Mater 6(8):2523\u20132534. https:\/\/doi.org\/10.1016\/j.bioactmat.2021.01.029","DOI":"10.1016\/j.bioactmat.2021.01.029"},{"issue":"15","key":"4954_CR5","doi-asserted-by":"publisher","first-page":"6391","DOI":"10.1021\/acs.nanolett.2c02259","volume":"22","author":"M Han","year":"2022","unstructured":"Han M, Yang H, Lu X, Li Y, Liu Z, Li F, Shang Z, Wang X et al (2022) Three-dimensional-cultured MSC-derived exosome-hydrogel hybrid microneedle array patch for spinal cord repair. Nano Lett 22(15):6391\u20136401. https:\/\/doi.org\/10.1021\/acs.nanolett.2c02259","journal-title":"Nano Lett"},{"issue":"4","key":"4954_CR6","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s12264-013-1438-4","volume":"30","author":"T Zhu","year":"2014","unstructured":"Zhu T, Tang Q, Gao H, Shen Y, Chen L, Zhu J (2014) Current status of cell-mediated regenerative therapies for human spinal cord injury. Neurosci Bull 30(4):671\u2013682. https:\/\/doi.org\/10.1007\/s12264-013-1438-4","journal-title":"Neurosci Bull"},{"issue":"4","key":"4954_CR7","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1242\/dev.054718","volume":"138","author":"NA Mundell","year":"2011","unstructured":"Mundell NA, Labosky PA (2011) Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates. Development 138(4):641\u2013652. https:\/\/doi.org\/10.1242\/dev.054718","journal-title":"Development"},{"key":"4954_CR8","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.expneurol.2017.12.012","volume":"302","author":"J Xiang","year":"2018","unstructured":"Xiang J, Wen F, Zhang L, Zhou Y (2018) FOXD3 inhibits SCN2A gene transcription in intractable epilepsy cell models. Exp Neurol 302:14\u201321. https:\/\/doi.org\/10.1016\/j.expneurol.2017.12.012","journal-title":"Exp Neurol"},{"issue":"1","key":"4954_CR9","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/s12276-019-0370-8","volume":"52","author":"R Li","year":"2020","unstructured":"Li R, Zhao K, Ruan Q, Meng C, Yin F (2020) The transcription factor Foxd3 induces spinal cord ischemia-reperfusion injury by potentiating microRNA-214-dependent inhibition of Kcnk2. Exp Mol Med 52(1):118\u2013129. https:\/\/doi.org\/10.1038\/s12276-019-0370-8","journal-title":"Exp Mol Med"},{"key":"4954_CR10","doi-asserted-by":"publisher","unstructured":"Liu C, Li J (2018) O-GlcNAc: a sweetheart of the cell cycle and DNA damage response. Front Endocrinol (Lausanne) 9:415. https:\/\/doi.org\/10.3389\/fendo.2018.00415","DOI":"10.3389\/fendo.2018.00415"},{"issue":"3","key":"4954_CR11","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s10863-018-9760-1","volume":"50","author":"O Lagerlof","year":"2018","unstructured":"Lagerlof O (2018) O-GlcNAc cycling in the developing, adult and geriatric brain. J Bioenerg Biomembr 50(3):241\u2013261. https:\/\/doi.org\/10.1007\/s10863-018-9760-1","journal-title":"J Bioenerg Biomembr"},{"key":"4954_CR12","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.actbio.2022.08.031","volume":"151","author":"X Liu","year":"2022","unstructured":"Liu X, Song S, Chen Z, Gao C, Li Y, Luo Y, Huang J, Zhang Z (2022) Release of O-GlcNAc transferase inhibitor promotes neuronal differentiation of neural stem cells in 3D bioprinted supramolecular hydrogel scaffold for spinal cord injury repair. Acta Biomater 151:148\u2013162. https:\/\/doi.org\/10.1016\/j.actbio.2022.08.031","journal-title":"Acta Biomater"},{"key":"4954_CR13","doi-asserted-by":"publisher","unstructured":"Zhao L, Shah JA, Cai Y, Jin J (2018) \u2018O-GlcNAc Code\u2019 mediated biological functions of downstream proteins. Molecules 23(8). https:\/\/doi.org\/10.3390\/molecules23081967","DOI":"10.3390\/molecules23081967"},{"issue":"6","key":"4954_CR14","doi-asserted-by":"publisher","first-page":"4535","DOI":"10.1128\/MCB.19.6.4535","volume":"19","author":"CA Ballinger","year":"1999","unstructured":"Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, Patterson C (1999) Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol 19(6):4535\u20134545. https:\/\/doi.org\/10.1128\/MCB.19.6.4535","journal-title":"Mol Cell Biol"},{"issue":"7","key":"4954_CR15","doi-asserted-by":"publisher","first-page":"107151","DOI":"10.1016\/j.isci.2023.107151","volume":"26","author":"Q Hu","year":"2023","unstructured":"Hu Q, Lei J, Cheng Z, Xu J, Wang L, Yuan Y, Gan M, Wang Y et al (2023) STUB1-mediated ubiquitination regulates the stability of GLUD1 in lung adenocarcinoma. iScience 26(7):107151. https:\/\/doi.org\/10.1016\/j.isci.2023.107151","journal-title":"iScience"},{"key":"4954_CR16","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.nbd.2018.05.012","volume":"122","author":"CJ Cortes","year":"2019","unstructured":"Cortes CJ, La Spada AR (2019) TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: molecular mechanisms, cellular processes, and emerging therapeutic opportunities. Neurobiol Dis 122:83\u201393. https:\/\/doi.org\/10.1016\/j.nbd.2018.05.012","journal-title":"Neurobiol Dis"},{"key":"4954_CR17","doi-asserted-by":"publisher","unstructured":"Lu E, Tang Y, Chen J, Al MA, Feng Z, Cao L, Zhang X, Zhu Y et al (2023) Stub1 ameliorates ER stress-induced neural cell apoptosis and promotes locomotor recovery through restoring autophagy flux after spinal cord injury. Exp Neurol 368:114495. https:\/\/doi.org\/10.1016\/j.expneurol.2023.114495","DOI":"10.1016\/j.expneurol.2023.114495"},{"key":"4954_CR18","doi-asserted-by":"publisher","first-page":"114541","DOI":"10.1016\/j.biopha.2023.114541","volume":"161","author":"J Mo","year":"2023","unstructured":"Mo J, Hu J, Cheng X (2023) The role of high mobility group box 1 in neuroinflammatory related diseases. Biomed Pharmacother 161:114541. https:\/\/doi.org\/10.1016\/j.biopha.2023.114541","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"4954_CR19","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1089\/neu.2016.4596","volume":"34","author":"A Papatheodorou","year":"2017","unstructured":"Papatheodorou A, Stein A, Bank M, Sison CP, Gibbs K, Davies P, Bloom O (2017) High-mobility group box 1 (HMGB1) is elevated systemically in persons with acute or chronic traumatic spinal cord injury. J Neurotrauma 34(3):746\u2013754. https:\/\/doi.org\/10.1089\/neu.2016.4596","journal-title":"J Neurotrauma"},{"issue":"1","key":"4954_CR20","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s12974-020-01973-4","volume":"17","author":"H Fan","year":"2020","unstructured":"Fan H, Tang HB, Chen Z, Wang HQ, Zhang L, Jiang Y, Li T, Yang CF et al (2020) Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages\/microglia polarization and affords neuroprotection after spinal cord injury. J Neuroinflammation 17(1):295. https:\/\/doi.org\/10.1186\/s12974-020-01973-4","journal-title":"J Neuroinflammation"},{"issue":"1","key":"4954_CR21","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00018-022-04637-z","volume":"80","author":"Y Sun","year":"2022","unstructured":"Sun Y, Wang Q, Wang M, Sun F, Qiao P, Jiang A, Ren C, Yu Z et al (2022) CHIP induces ubiquitination and degradation of HMGB1 to regulate glycolysis in ovarian endometriosis. Cell Mol Life Sci 80(1):13. https:\/\/doi.org\/10.1007\/s00018-022-04637-z","journal-title":"Cell Mol Life Sci"},{"key":"4954_CR22","doi-asserted-by":"publisher","unstructured":"Li K, Liu Z, Wu P, Chen S, Wang M, Liu W, Zhang L, Guo S et al (2023) Micro electrical fields induced MSC-sEVs attenuate neuronal cell apoptosis by activating autophagy via lncRNA MALAT1\/miR-22\u20133p\/SIRT1\/AMPK axis in spinal cord injury. J Nanobiotechnology 21(1):451. https:\/\/doi.org\/10.1186\/s12951-023-02217-2","DOI":"10.1186\/s12951-023-02217-2"},{"issue":"20","key":"4954_CR23","doi-asserted-by":"publisher","first-page":"9280","DOI":"10.7150\/thno.46566","volume":"10","author":"K Zhou","year":"2020","unstructured":"Zhou K, Zheng Z, Li Y, Han W, Zhang J, Mao Y, Chen H, Zhang W et al (2020) TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress. Theranostics 10(20):9280\u20139302. https:\/\/doi.org\/10.7150\/thno.46566","journal-title":"Theranostics"},{"key":"4954_CR24","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.jconrel.2021.01.032","volume":"331","author":"X Wang","year":"2021","unstructured":"Wang X, Wu J, Liu X, Tang K, Cheng L, Li J, Tang Y, Song X et al (2021) Engineered liposomes targeting the gut-CNS Axis for comprehensive therapy of spinal cord injury. J Control Release 331:390\u2013403. https:\/\/doi.org\/10.1016\/j.jconrel.2021.01.032","journal-title":"J Control Release"},{"key":"4954_CR25","doi-asserted-by":"publisher","unstructured":"Wu C, Chen Y, Chen X, Zhang Y, Zhao X, Deng Y, Li C, Zhang D et al (2024) 20-Deoxyingenol activates mitophagy through TFEB and promotes functional recovery after spinal cord injury. Mol Neurobiol. https:\/\/doi.org\/10.1007\/s12035-024-04283-5","DOI":"10.1007\/s12035-024-04283-5"},{"issue":"9","key":"4954_CR26","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.4103\/1673-5374.390953","volume":"19","author":"X Li","year":"2024","unstructured":"Li X, Fu J, Guan M, Shi H, Pan W, Lou X (2024) Biochanin A attenuates spinal cord injury in rats during early stages by inhibiting oxidative stress and inflammasome activation. Neural Regen Res 19(9):2050\u20132056. https:\/\/doi.org\/10.4103\/1673-5374.390953","journal-title":"Neural Regen Res"},{"issue":"1","key":"4954_CR27","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13578-022-00816-4","volume":"12","author":"M Xia","year":"2022","unstructured":"Xia M, Li X, Ye S, Zhang Q, Zhao T, Li R, Zhang Y, Xian M et al (2022) FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion. Cell Biosci 12(1):82. https:\/\/doi.org\/10.1186\/s13578-022-00816-4","journal-title":"Cell Biosci"},{"key":"4954_CR28","doi-asserted-by":"publisher","first-page":"176541","DOI":"10.1016\/j.ejphar.2024.176541","volume":"971","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Chen X, Wang X, Xu Y, Li J, Wu Y, Wang Z, Zhang S et al (2024) Hesperetin ameliorates spinal cord injury in rats through suppressing apoptosis, oxidative stress and inflammatory response. Eur J Pharmacol 971:176541. https:\/\/doi.org\/10.1016\/j.ejphar.2024.176541","journal-title":"Eur J Pharmacol"},{"key":"4954_CR29","doi-asserted-by":"publisher","unstructured":"Huang W, Wu D, Cai C, Yao H, Tian Z, Yang Y, Pang M, Rong L et al (2024) Inhibition of MST1 ameliorates neuronal apoptosis via GSK3beta\/beta-TrCP\/NRF2 pathway in spinal cord injury accompanied by diabetes. Redox Biol 71:103104. https:\/\/doi.org\/10.1016\/j.redox.2024.103104","DOI":"10.1016\/j.redox.2024.103104"},{"issue":"9","key":"4954_CR30","doi-asserted-by":"publisher","first-page":"e841","DOI":"10.1212\/WNL.0000000000007998","volume":"93","author":"Z Liu","year":"2019","unstructured":"Liu Z, Yang Y, He L, Pang M, Luo C, Liu B, Rong L (2019) High-dose methylprednisolone for acute traumatic spinal cord injury: a meta-analysis. Neurology 93(9):e841\u2013e850. https:\/\/doi.org\/10.1212\/WNL.0000000000007998","journal-title":"Neurology"},{"issue":"3","key":"4954_CR31","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.spinee.2022.09.009","volume":"23","author":"B Guan","year":"2023","unstructured":"Guan B, Fan Y, Zheng R, Fu R, Yao L, Wang W, Li G, Chen L et al (2023) A critical appraisal of clinical practice guidelines on pharmacological treatments for spinal cord injury. Spine J 23(3):392\u2013402. https:\/\/doi.org\/10.1016\/j.spinee.2022.09.009","journal-title":"Spine J"},{"issue":"2","key":"4954_CR32","first-page":"646","volume":"13","author":"J Wang","year":"2021","unstructured":"Wang J, Zhao Y, Tang Y, Li F, Chen X (2021) The role of lncRNA-MEG\/miR-21-5p\/PDCD4 axis in spinal cord injury. Am J Transl Res 13(2):646\u2013658","journal-title":"Am J Transl Res"},{"key":"4954_CR33","doi-asserted-by":"publisher","unstructured":"Ben AA, Lemaire Q, Scache J, Mariller C, Lefebvre T, Vercoutter-Edouart AS (2023) O-GlcNAc dynamics: the sweet side of protein trafficking regulation in mammalian cells. Cells 12(10). https:\/\/doi.org\/10.3390\/cells12101396","DOI":"10.3390\/cells12101396"},{"issue":"18","key":"4954_CR34","doi-asserted-by":"publisher","first-page":"10451","DOI":"10.1039\/d0cs01275k","volume":"50","author":"A Saha","year":"2021","unstructured":"Saha A, Bello D, Fernandez-Tejada A (2021) Advances in chemical probing of protein O-GlcNAc glycosylation: structural role and molecular mechanisms. Chem Soc Rev 50(18):10451\u201310485. https:\/\/doi.org\/10.1039\/d0cs01275k","journal-title":"Chem Soc Rev"},{"key":"4954_CR35","doi-asserted-by":"publisher","unstructured":"Hu J, Wang Y, Zhao S, Chen J, Jin S, Jia P, Ding X (2018) Remote ischemic preconditioning ameliorates acute kidney injury due to contrast exposure in rats through augmented O-GlcNAcylation. Oxid Med Cell Longev 2018:4895913. https:\/\/doi.org\/10.1155\/2018\/4895913","DOI":"10.1155\/2018\/4895913"},{"issue":"3","key":"4954_CR36","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.3233\/JAD-230955","volume":"97","author":"P Du","year":"2024","unstructured":"Du P, Zhang X, Lian X, Holscher C, Xue G (2024) O-GlcNAcylation and its roles in neurodegenerative diseases. J Alzheimers Dis 97(3):1051\u20131068. https:\/\/doi.org\/10.3233\/JAD-230955","journal-title":"J Alzheimers Dis"},{"issue":"5","key":"4954_CR37","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1021\/acschemneuro.9b00143","volume":"10","author":"P Ryan","year":"2019","unstructured":"Ryan P, Xu M, Davey AK, Danon JJ, Mellick GD, Kassiou M, Rudrawar S (2019) O-GlcNAc modification protects against protein misfolding and aggregation in neurodegenerative disease. ACS Chem Neurosci 10(5):2209\u20132221. https:\/\/doi.org\/10.1021\/acschemneuro.9b00143","journal-title":"ACS Chem Neurosci"},{"key":"4954_CR38","doi-asserted-by":"publisher","unstructured":"Huang Z, Zhang Y, Wang S, Qi R, Tao Y, Sun Y, Jiang D, Jiang X et al (2024) FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain via m(6)A-dependent stabilization of 5-HT3A mRNA in sensory neurons. Proc Natl Acad Sci U S A 121(6):e1982106175. https:\/\/doi.org\/10.1073\/pnas.2312861121","DOI":"10.1073\/pnas.2312861121"},{"issue":"4","key":"4954_CR39","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1379\/1466-1268(2003)008<0303:calbtc>2.0.co;2","volume":"8","author":"H Mcdonough","year":"2003","unstructured":"Mcdonough H, Patterson C (2003) CHIP: a link between the chaperone and proteasome systems. Cell Stress Chaperones 8(4):303\u2013308. https:\/\/doi.org\/10.1379\/1466-1268(2003)008<0303:calbtc>2.0.co;2","journal-title":"Cell Stress Chaperones"},{"issue":"1","key":"4954_CR40","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.molmed.2006.11.003","volume":"13","author":"CA Dickey","year":"2007","unstructured":"Dickey CA, Patterson C, Dickson D, Petrucelli L (2007) Brain CHIP: removing the culprits in neurodegenerative disease. Trends Mol Med 13(1):32\u201338. https:\/\/doi.org\/10.1016\/j.molmed.2006.11.003","journal-title":"Trends Mol Med"},{"issue":"7083","key":"4954_CR41","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nature04600","volume":"440","author":"SB Qian","year":"2006","unstructured":"Qian SB, Mcdonough H, Boellmann F, Cyr DM, Patterson C (2006) CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70. Nature 440(7083):551\u2013555. https:\/\/doi.org\/10.1038\/nature04600","journal-title":"Nature"},{"key":"4954_CR42","doi-asserted-by":"publisher","unstructured":"Kim C, Yun N, Lee J, Youdim MB, Ju C, Kim WK, Han PL, Oh YJ (2016) Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal death. Cell Death Differ 23(2):333\u2013346. https:\/\/doi.org\/10.1038\/cdd.2015.103","DOI":"10.1038\/cdd.2015.103"},{"key":"4954_CR43","doi-asserted-by":"publisher","first-page":"102701","DOI":"10.1016\/j.dnarep.2019.102701","volume":"83","author":"P Mandke","year":"2019","unstructured":"Mandke P, Vasquez KM (2019) Interactions of high mobility group box protein 1 (HMGB1) with nucleic acids: implications in DNA repair and immune responses. DNA Repair (Amst) 83:102701. https:\/\/doi.org\/10.1016\/j.dnarep.2019.102701","journal-title":"DNA Repair (Amst)"},{"key":"4954_CR44","doi-asserted-by":"publisher","first-page":"110802","DOI":"10.1016\/j.intimp.2023.110802","volume":"123","author":"L Guo","year":"2023","unstructured":"Guo L, Zhang D, Ren X, Liu D (2023) SYVN1 attenuates ferroptosis and alleviates spinal cord ischemia-reperfusion injury in rats by regulating the HMGB1\/NRF2\/HO-1 axis. Int Immunopharmacol 123:110802. https:\/\/doi.org\/10.1016\/j.intimp.2023.110802","journal-title":"Int Immunopharmacol"},{"key":"4954_CR45","doi-asserted-by":"publisher","unstructured":"Fan R, Wang L, Botchway B, Zhang Y, Liu X (2022) Protective role of ethyl pyruvate in spinal cord injury by inhibiting the high mobility group box-1\/toll-like receptor4\/nuclear factor-kappa B signaling pathway. Front Mol Neurosci 15:1013033. https:\/\/doi.org\/10.3389\/fnmol.2022.1013033","DOI":"10.3389\/fnmol.2022.1013033"},{"issue":"3","key":"4954_CR46","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1007\/s10571-022-01240-5","volume":"43","author":"Z Wu","year":"2023","unstructured":"Wu Z, Li M (2023) High-mobility group box 1 in spinal cord injury and its potential role in brain functional remodeling after spinal cord injury. Cell Mol Neurobiol 43(3):1005\u20131017. https:\/\/doi.org\/10.1007\/s10571-022-01240-5","journal-title":"Cell Mol Neurobiol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-04954-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-04954-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-04954-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T04:07:22Z","timestamp":1755662842000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-04954-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,24]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["4954"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-04954-x","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,24]]},"assertion":[{"value":"24 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiment procedures were in accordance with Animal Welfare Act regulations and public health service guidelines. All experiment protocols were approved by the Ethical Review Committee of the First Affiliated Hospital of Nanchang University (Jiangxi, China).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}