{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:18:42Z","timestamp":1793744322417,"version":"4.6.1"},"reference-count":179,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s12035-025-04968-5","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T08:26:19Z","timestamp":1746519979000},"page":"14613-14626","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Role and Relationship Between Homocysteine and H2S in Ischemic Stroke"],"prefix":"10.1007","volume":"62","author":[{"given":"Weizhuo","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyue","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"4968_CR1","first-page":"477","volume":"20","author":"S Xu","year":"2020","unstructured":"Xu S, Shi Q, Li B et al (2020) High MTHFR promoter methylation levels in men confer protection against ischemic stroke. Bosnian J Basic Med Sci Udruzenje Basicnih Mediciniskih Znanosti 20:477\u2013486","journal-title":"Bosnian J Basic Med Sci Udruzenje Basicnih Mediciniskih Znanosti"},{"key":"4968_CR2","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1111\/bph.13988","volume":"175","author":"Y Fu","year":"2018","unstructured":"Fu Y, Wang X, Kong W (2018) Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets. Br J Pharmacol 175:1173\u20131189","journal-title":"Br J Pharmacol"},{"key":"4968_CR3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1080\/13510002.2021.1952819","volume":"26","author":"MY Maksimova","year":"2021","unstructured":"Maksimova MY, Ivanov AV, Virus ED et al (2021) Impact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status. Redox Rep 26:117\u2013123","journal-title":"Redox Rep"},{"key":"4968_CR4","first-page":"454","volume":"21","author":"J Wang","year":"2021","unstructured":"Wang J, Gu J, Huang Y, Fang Y, Lin J (2021) The association between serine hydroxymethyl transferase 1 gene hypermethylation and ischemic stroke. Bosnian J Basic Med Sci Udruzenje Basicnih Mediciniskih Znanosti 21:454\u2013460","journal-title":"Bosnian J Basic Med Sci Udruzenje Basicnih Mediciniskih Znanosti"},{"key":"4968_CR5","doi-asserted-by":"publisher","first-page":"7698","DOI":"10.3390\/ijms21207698","volume":"21","author":"P Kaplan","year":"2020","unstructured":"Kaplan P, Tatarkova Z, Sivonova MK, Racay P, Lehotsky J (2020) Homocysteine and mitochondria in cardiovascular and cerebrovascular systems. Int J Mol Sci 21:7698","journal-title":"Int J Mol Sci"},{"key":"4968_CR6","doi-asserted-by":"publisher","first-page":"7629673","DOI":"10.1155\/2019\/7629673","volume":"2019","author":"Q Yang","year":"2019","unstructured":"Yang Q, He GW (2019) Imbalance of homocysteine and H(2)S: significance, mechanisms, and therapeutic promise in vascular injury. Oxid Med Cell Longev 2019:7629673","journal-title":"Oxid Med Cell Longev"},{"key":"4968_CR7","doi-asserted-by":"publisher","first-page":"3179","DOI":"10.1007\/s12035-023-03797-8","volume":"61","author":"Y Ding","year":"2024","unstructured":"Ding Y, Fang F, Liu X et al (2024) H(2)S regulates the phenotypic transformation of astrocytes following cerebral ischemia\/reperfusion via inhibiting the RhoA\/ROCK pathway. Mol Neurobiol 61:3179\u20133197","journal-title":"Mol Neurobiol"},{"key":"4968_CR8","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","volume":"16","author":"K Abe","year":"1996","unstructured":"Abe K, Kimura H (1996) The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 16:1066\u20131071","journal-title":"J Neurosci"},{"key":"4968_CR9","doi-asserted-by":"crossref","unstructured":"Fan J, Du J, Zhang Z et al (2022) The protective effects of hydrogen sulfide new donor methyl S-(4-fluorobenzyl)-N-(3,4,5-trimethoxybenzoyl)-l-cysteinate on the ischemic stroke. Molecules 27","DOI":"10.3390\/molecules27051554"},{"key":"4968_CR10","doi-asserted-by":"publisher","first-page":"4155","DOI":"10.1111\/bph.15607","volume":"178","author":"JY Wen","year":"2021","unstructured":"Wen JY, Zhang J, Chen S et al (2021) Endothelium-derived hydrogen sulfide acts as a hyperpolarizing factor and exerts neuroprotective effects via activation of large-conductance Ca(2+) -activated K(+) channels. Br J Pharmacol 178:4155\u20134175","journal-title":"Br J Pharmacol"},{"key":"4968_CR11","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.brainres.2015.07.001","volume":"1622","author":"X Wei","year":"2015","unstructured":"Wei X, Zhang B, Cheng L et al (2015) Hydrogen sulfide induces neuroprotection against experimental stroke in rats by down-regulation of AQP4 via activating PKC. Brain Res 1622:292\u2013299","journal-title":"Brain Res"},{"key":"4968_CR12","doi-asserted-by":"publisher","first-page":"538","DOI":"10.3389\/fnins.2016.00538","volume":"10","author":"J Lehotsky","year":"2016","unstructured":"Lehotsky J, Tothova B, Kovalska M et al (2016) Role of homocysteine in the ischemic stroke and development of ischemic tolerance. Front Neurosci 10:538","journal-title":"Front Neurosci"},{"key":"4968_CR13","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/jcb.27603","volume":"120","author":"A Majumder","year":"2019","unstructured":"Majumder A, Singh M, George AK, Homme RP, Laha A, Tyagi SC (2019) Remote ischemic conditioning as a cytoprotective strategy in vasculopathies during hyperhomocysteinemia: an emerging research perspective. J Cell Biochem 120:77\u201392","journal-title":"J Cell Biochem"},{"key":"4968_CR14","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1055\/s-2000-8467","volume":"26","author":"HJ Blom","year":"2000","unstructured":"Blom HJ (2000) Consequences of homocysteine export and oxidation in the vascular system. Semin Thromb Hemost 26:227\u2013232","journal-title":"Semin Thromb Hemost"},{"key":"4968_CR15","doi-asserted-by":"publisher","first-page":"139769","DOI":"10.1016\/j.chemosphere.2023.139769","volume":"339","author":"F Jiao","year":"2023","unstructured":"Jiao F, Zhao Y, Limbu SM et al (2023) Cyhexatin causes developmental toxic effects by disrupting endocrine system and inducing behavioral inhibition, apoptosis and DNA hypomethylation in zebrafish (Danio rerio) larvae. Chemosphere 339:139769","journal-title":"Chemosphere"},{"key":"4968_CR16","doi-asserted-by":"publisher","first-page":"928701","DOI":"10.3389\/fcvm.2022.928701","volume":"9","author":"C Wan","year":"2022","unstructured":"Wan C, Zong RY, Chen XS (2022) The new mechanism of cognitive decline induced by hypertension: high homocysteine-mediated aberrant DNA methylation. Front Cardiovasc Med 9:928701","journal-title":"Front Cardiovasc Med"},{"key":"4968_CR17","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1002\/jcb.29527","volume":"122","author":"D Zhang","year":"2021","unstructured":"Zhang D, Hong X, Wang J et al (2021) Estradiol-17beta inhibits homocysteine mediated damage by promoting H(2) S production via upregulating CBS and CSE expression in human umbilical vein endothelial cells. J Cell Biochem 122:915\u2013925","journal-title":"J Cell Biochem"},{"key":"4968_CR18","doi-asserted-by":"publisher","first-page":"e3002439","DOI":"10.1371\/journal.pbio.3002439","volume":"21","author":"YAE Sonal","year":"2023","unstructured":"Sonal YAE, Yang X, Shou W (2023) Collective production of hydrogen sulfide gas enables budding yeast lacking MET17 to overcome their metabolic defect. PLoS Biol 21:e3002439","journal-title":"PLoS Biol"},{"key":"4968_CR19","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1096\/fj.08-127548","volume":"23","author":"H Jakubowski","year":"2009","unstructured":"Jakubowski H, Perla-Kajan J, Finnell RH et al (2009) Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice. FASEB J 23:1721\u20131727","journal-title":"FASEB J"},{"key":"4968_CR20","doi-asserted-by":"publisher","first-page":"6290931","DOI":"10.1155\/2018\/6290931","volume":"2018","author":"A Giuffre","year":"2018","unstructured":"Giuffre A, Vicente JB (2018) Hydrogen sulfide biochemistry and interplay with other gaseous mediators in mammalian physiology. Oxid Med Cell Longev 2018:6290931","journal-title":"Oxid Med Cell Longev"},{"key":"4968_CR21","doi-asserted-by":"publisher","first-page":"C720","DOI":"10.1152\/ajpcell.00014.2020","volume":"319","author":"F Zhang","year":"2020","unstructured":"Zhang F, Chen S, Wen JY, Chen ZW (2020) 3-Mercaptopyruvate sulfurtransferase\/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation\/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA\/ROCK pathway. Am J Physiol Cell Physiol 319:C720\u2013C733","journal-title":"Am J Physiol Cell Physiol"},{"key":"4968_CR22","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s11883-003-0050-x","volume":"5","author":"DE Handy","year":"2003","unstructured":"Handy DE, Loscalzo J (2003) Homocysteine and atherothrombosis: diagnosis and treatment. Curr Atheroscler Rep 5:276\u2013283","journal-title":"Curr Atheroscler Rep"},{"key":"4968_CR23","doi-asserted-by":"publisher","first-page":"12560","DOI":"10.3390\/ijms160612560","volume":"16","author":"JJ Li","year":"2015","unstructured":"Li JJ, Li Q, Du HP et al (2015) Homocysteine triggers inflammatory responses in macrophages through inhibiting CSE-H2S signaling via DNA Hypermethylation of CSE promoter. Int J Mol Sci 16:12560\u201312577","journal-title":"Int J Mol Sci"},{"key":"4968_CR24","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.bbr.2014.01.001","volume":"262","author":"MH Li","year":"2014","unstructured":"Li MH, Tang JP, Zhang P et al (2014) Disturbance of endogenous hydrogen sulfide generation and endoplasmic reticulum stress in hippocampus are involved in homocysteine-induced defect in learning and memory of rats. Behav Brain Res 262:35\u201341","journal-title":"Behav Brain Res"},{"key":"4968_CR25","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s12031-010-9477-z","volume":"45","author":"XQ Tang","year":"2011","unstructured":"Tang XQ, Shen XT, Huang YE et al (2011) Inhibition of endogenous hydrogen sulfide generation is associated with homocysteine-induced neurotoxicity: role of ERK1\/2 activation. J Mol Neurosci 45:60\u201367","journal-title":"J Mol Neurosci"},{"key":"4968_CR26","doi-asserted-by":"publisher","first-page":"11601","DOI":"10.1074\/jbc.M808026200","volume":"284","author":"T Chiku","year":"2009","unstructured":"Chiku T, Padovani D, Zhu W, Singh S, Vitvitsky V, Banerjee R (2009) H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. J Biol Chem 284:11601\u201311612","journal-title":"J Biol Chem"},{"key":"4968_CR27","first-page":"c106","volume":"108","author":"S Palleschi","year":"2008","unstructured":"Palleschi S, De Angelis S, Rossi B et al (2008) Homocysteinemia correlates with plasma thiol redox status in patients with end-stage renal disease. Nephron: Clin Pract 108:c106-112","journal-title":"Nephron: Clin Pract"},{"key":"4968_CR28","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s00726-007-0011-8","volume":"34","author":"L Chang","year":"2008","unstructured":"Chang L, Geng B, Yu F et al (2008) Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats. Amino Acids 34:573\u2013585","journal-title":"Amino Acids"},{"key":"4968_CR29","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1080\/10715762.2018.1431626","volume":"52","author":"R Parsanathan","year":"2018","unstructured":"Parsanathan R, Jain SK (2018) Hydrogen sulfide increases glutathione biosynthesis, and glucose uptake and utilisation in C(2)C(12) mouse myotubes. Free Radic Res 52:288\u2013303","journal-title":"Free Radic Res"},{"key":"4968_CR30","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1080\/14756366.2018.1509211","volume":"33","author":"D Giustarini","year":"2018","unstructured":"Giustarini D, Tazzari V, Bassanini I, Rossi R, Sparatore A (2018) The new H(2)S-releasing compound ACS94 exerts protective effects through the modulation of thiol homoeostasis. J Enzyme Inhib Med Chem 33:1392\u20131404","journal-title":"J Enzyme Inhib Med Chem"},{"key":"4968_CR31","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1089\/ars.2008.2073","volume":"11","author":"N Tyagi","year":"2009","unstructured":"Tyagi N, Moshal KS, Sen U et al (2009) H2S protects against methionine-induced oxidative stress in brain endothelial cells. Antioxid Redox Signal 11:25\u201333","journal-title":"Antioxid Redox Signal"},{"key":"4968_CR32","doi-asserted-by":"publisher","first-page":"3923","DOI":"10.1182\/blood-2009-10-249722","volume":"115","author":"TJ Lightfoot","year":"2010","unstructured":"Lightfoot TJ, Johnston WT, Painter D et al (2010) Genetic variation in the folate metabolic pathway and risk of childhood leukemia. Blood 115:3923\u20133929","journal-title":"Blood"},{"key":"4968_CR33","doi-asserted-by":"publisher","first-page":"2684","DOI":"10.1167\/iovs.14-16190","volume":"56","author":"S Markand","year":"2015","unstructured":"Markand S, Saul A, Roon P et al (2015) Retinal ganglion cell loss and mild vasculopathy in methylene tetrahydrofolate reductase (Mthfr)-deficient mice: a model of mild hyperhomocysteinemia. Invest Ophthalmol Vis Sci 56:2684\u20132695","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4968_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/ars.2021.0029","volume":"36","author":"D Ji","year":"2022","unstructured":"Ji D, Luo C, Liu J et al (2022) Insufficient S-sulfhydration of methylenetetrahydrofolate reductase contributes to the progress of hyperhomocysteinemia. Antioxid Redox Signal 36:1\u201314","journal-title":"Antioxid Redox Signal"},{"key":"4968_CR35","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.2337\/db16-0020","volume":"65","author":"L Xie","year":"2016","unstructured":"Xie L, Gu Y, Wen M et al (2016) Hydrogen sulfide induces Keap1 S-sulfhydration and suppresses diabetes-accelerated atherosclerosis via Nrf2 activation. Diabetes 65:3171\u20133184","journal-title":"Diabetes"},{"key":"4968_CR36","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/S1474-4422(17)30180-1","volume":"16","author":"JD Spence","year":"2017","unstructured":"Spence JD, Yi Q, Hankey GJ (2017) B vitamins in stroke prevention: time to reconsider. Lancet Neurol 16:750\u2013760","journal-title":"Lancet Neurol"},{"key":"4968_CR37","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1017\/S0029665108007076","volume":"67","author":"H Mcnulty","year":"2008","unstructured":"Mcnulty H, Pentieva K, Hoey L, Ward M (2008) Homocysteine, B-vitamins and CVD. Proc Nutr Soc 67:232\u2013237","journal-title":"Proc Nutr Soc"},{"key":"4968_CR38","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1017\/S0954422409990023","volume":"22","author":"C Sanchez-Moreno","year":"2009","unstructured":"Sanchez-Moreno C, Jimenez-Escrig A, Martin A (2009) Stroke: roles of B vitamins, homocysteine and antioxidants. Nutr Res Rev 22:49\u201367","journal-title":"Nutr Res Rev"},{"key":"4968_CR39","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1111\/1744-7917.12976","volume":"29","author":"J Li","year":"2022","unstructured":"Li J, Li F, Yu N, Liu Z (2022) The betaine-dependent remethylation pathway is a homocysteine metabolism pathway associated with the carnivorous feeding habits of spiders. Insect Sci 29:1047\u20131058","journal-title":"Insect Sci"},{"key":"4968_CR40","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.3390\/ijms17101733","volume":"17","author":"H Skovierova","year":"2016","unstructured":"Skovierova H, Vidomanova E, Mahmood S et al (2016) The molecular and cellular effect of homocysteine metabolism imbalance on human health. Int J Mol Sci 17:1733","journal-title":"Int J Mol Sci"},{"key":"4968_CR41","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.2174\/0929867325666180313105949","volume":"26","author":"BL Zaric","year":"2019","unstructured":"Zaric BL, Obradovic M, Bajic V, Haidara MA, Jovanovic M, Isenovic ER (2019) Homocysteine and hyperhomocysteinaemia. Curr Med Chem 26:2948\u20132961","journal-title":"Curr Med Chem"},{"key":"4968_CR42","doi-asserted-by":"publisher","first-page":"1184141","DOI":"10.3389\/fneur.2023.1184141","volume":"14","author":"P Zhang","year":"2023","unstructured":"Zhang P, Xie X, Zhang Y (2023) Associations between homocysteine and B vitamins and stroke: a cross-sectional study. Front Neurol 14:1184141","journal-title":"Front Neurol"},{"key":"4968_CR43","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3390\/biom12020197","volume":"12","author":"Y Menezo","year":"2022","unstructured":"Menezo Y, Elder K, Clement A, Clement P (2022) Folic Acid, folinic acid, 5 methyl tetrahydrofolate supplementation for mutations that affect epigenesis through the folate and one-carbon cycles. Biomolecules 12:197","journal-title":"Biomolecules"},{"key":"4968_CR44","doi-asserted-by":"publisher","first-page":"4149","DOI":"10.1007\/s12325-020-01474-z","volume":"37","author":"AD Kaye","year":"2020","unstructured":"Kaye AD, Jeha GM, Pham AD et al (2020) Folic acid supplementation in patients with elevated homocysteine levels. Adv Ther 37:4149\u20134164","journal-title":"Adv Ther"},{"key":"4968_CR45","first-page":"70","volume":"46","author":"AA Liakishev","year":"2006","unstructured":"Liakishev AA (2006) Homocysteine lowering with folic acid and B vitamins in vascular disease. Kardiologiia 46:70","journal-title":"Kardiologiia"},{"key":"4968_CR46","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1007\/s12272-018-1016-4","volume":"41","author":"J Kim","year":"2018","unstructured":"Kim J, Kim H, Roh H, Kwon Y (2018) Causes of hyperhomocysteinemia and its pathological significance. Arch Pharmacal Res 41:372\u2013383","journal-title":"Arch Pharmacal Res"},{"key":"4968_CR47","first-page":"267","volume":"3","author":"MA Avila","year":"2005","unstructured":"Avila MA, Berasain C, Prieto J, Mato JM, Garcia-Trevijano ER, Corrales FJ (2005) Influence of impaired liver methionine metabolism on the development of vascular disease and inflammation. Curr Med Chem Cardiovasc Hematol Agents 3:267\u2013281","journal-title":"Curr Med Chem Cardiovasc Hematol Agents"},{"key":"4968_CR48","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1681\/ASN.V12102181","volume":"12","author":"AN Friedman","year":"2001","unstructured":"Friedman AN, Bostom AG, Selhub J, Levey AS, Rosenberg IH (2001) The kidney and homocysteine metabolism. J Am Soc Nephrol 12:2181\u20132189","journal-title":"J Am Soc Nephrol"},{"key":"4968_CR49","doi-asserted-by":"publisher","first-page":"e1258","DOI":"10.1002\/iid3.1258","volume":"12","author":"J Li","year":"2024","unstructured":"Li J, Tian S, Ci B, Xi Y, Deng X (2024) Serum vitamins and homocysteine levels in autoimmune liver disease: a systematic review and meta-analysis. Immun Inflamm Dis 12:e1258","journal-title":"Immun Inflamm Dis"},{"issue":"Suppl 2","key":"4968_CR50","doi-asserted-by":"publisher","first-page":"S45","DOI":"10.1007\/PL00014303","volume":"157","author":"H Refsum","year":"1998","unstructured":"Refsum H, Guttormsen AB, Fiskerstrand T, Ueland PM (1998) Hyperhomocysteinemia in terms of steady-state kinetics. Eur J Pediatr 157(Suppl 2):S45-49","journal-title":"Eur J Pediatr"},{"key":"4968_CR51","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1046\/j.1365-2362.1996.137273.x","volume":"26","author":"EF Van Der Molen","year":"1996","unstructured":"Van Der Molen EF, Van Den Heuvel LP, Te Poele Pothoff MT, Monnens IA, Eskes TK, Blom HJ (1996) The effect of folic acid on the homocysteine metabolism in human umbilical vein endothelial cells (HUVECs). Eur J Clin Invest 26:304\u2013309","journal-title":"Eur J Clin Invest"},{"key":"4968_CR52","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1055\/s-0038-1657636","volume":"78","author":"EF Van Der Molen","year":"1997","unstructured":"Van Der Molen EF, Hiipakka MJ, Van Lith-Zanders H et al (1997) Homocysteine metabolism in endothelial cells of a patient homozygous for cystathionine beta-synthase (CS) deficiency. Thromb Haemost 78:827\u2013833","journal-title":"Thromb Haemost"},{"key":"4968_CR53","first-page":"15","volume":"65","author":"M Petras","year":"2014","unstructured":"Petras M, Tatarkova Z, Kovalska M et al (2014) Hyperhomocysteinemia as a risk factor for the neuronal system disorders. J Physiol Pharmacol 65:15\u201323","journal-title":"J Physiol Pharmacol"},{"key":"4968_CR54","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/j.1365-2141.2005.05913.x","volume":"132","author":"YM Smulders","year":"2006","unstructured":"Smulders YM, Smith DE, Kok RM et al (2006) Cellular folate vitamer distribution during and after correction of vitamin B12 deficiency: a case for the methylfolate trap. Br J Haematol 132:623\u2013629","journal-title":"Br J Haematol"},{"key":"4968_CR55","doi-asserted-by":"publisher","first-page":"101322","DOI":"10.1016\/j.redox.2019.101322","volume":"28","author":"W Shen","year":"2020","unstructured":"Shen W, Gao C, Cueto R et al (2020) Homocysteine-methionine cycle is a metabolic sensor system controlling methylation-regulated pathological signaling. Redox Biol 28:101322","journal-title":"Redox Biol"},{"key":"4968_CR56","doi-asserted-by":"publisher","first-page":"2156483","DOI":"10.1155\/2022\/2156483","volume":"2022","author":"J Lu","year":"2022","unstructured":"Lu J, Chen K, Chen W et al (2022) Association of serum homocysteine with cardiovascular and all-cause mortality in adults with diabetes: a prospective cohort study. Oxid Med Cell Longev 2022:2156483","journal-title":"Oxid Med Cell Longev"},{"key":"4968_CR57","first-page":"5659","volume":"13","author":"WL Li","year":"2021","unstructured":"Li WL, Sang H, Xu X et al (2021) The correlation study on homocysteine, blood lipids and blood glucose levels in patients with cerebral infarction. Am J Transl Res 13:5659\u20135664","journal-title":"Am J Transl Res"},{"key":"4968_CR58","doi-asserted-by":"publisher","first-page":"158","DOI":"10.2174\/157340209788166940","volume":"5","author":"Z Cheng","year":"2009","unstructured":"Cheng Z, Yang X, Wang H (2009) Hyperhomocysteinemia and endothelial dysfunction. Curr Hypertens Rev 5:158\u2013165","journal-title":"Curr Hypertens Rev"},{"key":"4968_CR59","doi-asserted-by":"publisher","first-page":"102018","DOI":"10.1016\/j.redox.2021.102018","volume":"45","author":"M Jan","year":"2021","unstructured":"Jan M, Cueto R, Jiang X et al (2021) Molecular processes mediating hyperhomocysteinemia-induced metabolic reprogramming, redox regulation and growth inhibition in endothelial cells. Redox Biol 45:102018","journal-title":"Redox Biol"},{"key":"4968_CR60","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1523\/JNEUROSCI.1333-22.2023","volume":"43","author":"P Sompol","year":"2023","unstructured":"Sompol P, Gollihue JL, Weiss BE et al (2023) Targeting astrocyte signaling alleviates cerebrovascular and synaptic function deficits in a diet-based mouse model of small cerebral vessel disease. J Neurosci 43:1797\u20131813","journal-title":"J Neurosci"},{"key":"4968_CR61","doi-asserted-by":"publisher","first-page":"634","DOI":"10.2471\/BLT.16.181636","volume":"94","author":"W Johnson","year":"2016","unstructured":"Johnson W, Onuma O, Owolabi M, Sachdev S (2016) Stroke: a global response is needed. Bull World Health Organ 94:634-634A","journal-title":"Bull World Health Organ"},{"key":"4968_CR62","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.5830\/CVJA-2015-038","volume":"26","author":"MO Owolabi","year":"2015","unstructured":"Owolabi MO, Akarolo-Anthony S, Akinyemi R et al (2015) The burden of stroke in Africa: a glance at the present and a glimpse into the future. Cardiovasc J Afr 26:S27-38","journal-title":"Cardiovasc J Afr"},{"key":"4968_CR63","first-page":"e5625","volume":"11","author":"F Niazi","year":"2019","unstructured":"Niazi F, Aslam A, Khattak S, Waheed S (2019) Frequency of homocysteinemia in young ischemic stroke patients and its relationship with the early outcome of a stroke. Cureus 11:e5625","journal-title":"Cureus"},{"key":"4968_CR64","doi-asserted-by":"publisher","first-page":"3268","DOI":"10.12659\/MSM.900010","volume":"22","author":"ES Yao","year":"2016","unstructured":"Yao ES, Tang Y, Xie MJ, Wang MH, Wang H, Luo X (2016) Elevated homocysteine level related to poor outcome after thrombolysis in acute ischemic stroke. Med Sci Monit 22:3268\u20133273","journal-title":"Med Sci Monit"},{"key":"4968_CR65","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.1161\/STROKEAHA.121.034388","volume":"52","author":"PJ Kelly","year":"2021","unstructured":"Kelly PJ, Lemmens R, Tsivgoulis G (2021) Inflammation and stroke risk: a new target for prevention. Stroke 52:2697\u20132706","journal-title":"Stroke"},{"key":"4968_CR66","doi-asserted-by":"publisher","first-page":"e420","DOI":"10.1055\/s-0041-1735978","volume":"5","author":"M Holmen","year":"2021","unstructured":"Holmen M, Hvas AM, Arendt JFH (2021) Hyperhomocysteinemia and ischemic stroke: a potential dose-response association-a systematic review and meta-analysis. TH Open 5:e420\u2013e437","journal-title":"TH Open"},{"key":"4968_CR67","first-page":"4174","volume":"14","author":"CF Huang","year":"2017","unstructured":"Huang CF, Wang WN, Sun CC et al (2017) Echinocystic acid ameliorates hyperhomocysteinemia-induced vascular endothelial cell injury through regulating NF-kappaB and CYP1A1. Exp Ther Med 14:4174\u20134180","journal-title":"Exp Ther Med"},{"key":"4968_CR68","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1161\/01.RES.84.4.409","volume":"84","author":"NP Dudman","year":"1999","unstructured":"Dudman NP, Temple SE, Guo XW, Fu W, Perry MA (1999) Homocysteine enhances neutrophil-endothelial interactions in both cultured human cells and rats In vivo. Circ Res 84:409\u2013416","journal-title":"Circ Res"},{"key":"4968_CR69","doi-asserted-by":"publisher","first-page":"e00460","DOI":"10.1002\/brb3.460","volume":"6","author":"P Forti","year":"2016","unstructured":"Forti P, Maioli F, Arnone G et al (2016) Homocysteinemia and early outcome of acute ischemic stroke in elderly patients. Brain Behav 6:e00460","journal-title":"Brain Behav"},{"key":"4968_CR70","doi-asserted-by":"publisher","first-page":"113541","DOI":"10.1016\/j.expneurol.2020.113541","volume":"336","author":"R Poddar","year":"2021","unstructured":"Poddar R (2021) Hyperhomocysteinemia is an emerging comorbidity in ischemic stroke. Exp Neurol 336:113541","journal-title":"Exp Neurol"},{"key":"4968_CR71","doi-asserted-by":"publisher","first-page":"e19467","DOI":"10.1097\/MD.0000000000019467","volume":"99","author":"T Zhang","year":"2020","unstructured":"Zhang T, Jiang Y, Zhang S et al (2020) The association between homocysteine and ischemic stroke subtypes in Chinese: a meta-analysis. Medicine (Baltimore) 99:e19467","journal-title":"Medicine (Baltimore)"},{"key":"4968_CR72","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/ana.25440","volume":"85","author":"SC Larsson","year":"2019","unstructured":"Larsson SC, Traylor M, Markus HS (2019) Homocysteine and small vessel stroke: a mendelian randomization analysis. Ann Neurol 85:495\u2013501","journal-title":"Ann Neurol"},{"key":"4968_CR73","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.atherosclerosis.2014.06.021","volume":"236","author":"X Pang","year":"2014","unstructured":"Pang X, Liu J, Zhao J et al (2014) Homocysteine induces the expression of C-reactive protein via NMDAr-ROS-MAPK-NF-kappaB signal pathway in rat vascular smooth muscle cells. Atherosclerosis 236:73\u201381","journal-title":"Atherosclerosis"},{"key":"4968_CR74","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/s12974-017-0963-x","volume":"14","author":"S Chen","year":"2017","unstructured":"Chen S, Dong Z, Cheng M et al (2017) Homocysteine exaggerates microglia activation and neuroinflammation through microglia localized STAT3 overactivation following ischemic stroke. J Neuroinflammation 14:187","journal-title":"J Neuroinflammation"},{"key":"4968_CR75","doi-asserted-by":"publisher","first-page":"818","DOI":"10.3892\/etm.2020.8759","volume":"20","author":"Y Zhao","year":"2020","unstructured":"Zhao Y, Tang N, Xi D et al (2020) Calcilytic NPS2143 promotes proliferation and inhibits apoptosis of spontaneously hypertensive rat vascular smooth muscle cells via activation of the renin-angiotensin system. Exp Ther Med 20:818\u2013829","journal-title":"Exp Ther Med"},{"key":"4968_CR76","doi-asserted-by":"publisher","first-page":"16904","DOI":"10.1038\/s41598-024-68122-2","volume":"14","author":"Y Tong","year":"2024","unstructured":"Tong Y, Wang DD, Zhang YL et al (2024) MiR-196a-5p hinders vascular smooth muscle cell proliferation and vascular remodeling via repressing BACH1 expression. Sci Rep 14:16904","journal-title":"Sci Rep"},{"key":"4968_CR77","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s11010-017-3142-6","volume":"439","author":"XL Zhan","year":"2018","unstructured":"Zhan XL, Yang XH, Gu YH, Guo LL, Jin HM (2018) Epigallocatechin gallate protects against homocysteine-induced vascular smooth muscle cell proliferation. Mol Cell Biochem 439:131\u2013140","journal-title":"Mol Cell Biochem"},{"key":"4968_CR78","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41467-017-02401-7","volume":"9","author":"T Li","year":"2018","unstructured":"Li T, Yu B, Liu Z et al (2018) Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury. Nat Commun 9:11","journal-title":"Nat Commun"},{"key":"4968_CR79","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/jcbfm.2008.99","volume":"29","author":"MM Alam","year":"2009","unstructured":"Alam MM, Mohammad AA, Shuaib U et al (2009) Homocysteine reduces endothelial progenitor cells in stroke patients through apoptosis. J Cereb Blood Flow Metab 29:157\u2013165","journal-title":"J Cereb Blood Flow Metab"},{"key":"4968_CR80","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/jnr.490320108","volume":"32","author":"A Grieve","year":"1992","unstructured":"Grieve A, Butcher SP, Griffiths R (1992) Synaptosomal plasma membrane transport of excitatory sulphur amino acid transmitter candidates: kinetic characterisation and analysis of carrier specificity. J Neurosci Res 32:60\u201368","journal-title":"J Neurosci Res"},{"key":"4968_CR81","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/S0969-9961(03)00070-6","volume":"14","author":"PI Ho","year":"2003","unstructured":"Ho PI, Ashline D, Dhitavat S et al (2003) Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine. Neurobiol Dis 14:32\u201342","journal-title":"Neurobiol Dis"},{"key":"4968_CR82","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1515\/CCLM.2011.084","volume":"49","author":"W Herrmann","year":"2011","unstructured":"Herrmann W, Obeid R (2011) Homocysteine: a biomarker in neurodegenerative diseases. Clin Chem Lab Med 49:435\u2013441","journal-title":"Clin Chem Lab Med"},{"key":"4968_CR83","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1182\/blood-2005-06-2506","volume":"107","author":"AF Kamath","year":"2006","unstructured":"Kamath AF, Chauhan AK, Kisucka J et al (2006) Elevated levels of homocysteine compromise blood-brain barrier integrity in mice. Blood 107:591\u2013593","journal-title":"Blood"},{"key":"4968_CR84","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1080\/00207454.2020.1860967","volume":"132","author":"M Kumar","year":"2022","unstructured":"Kumar M, Sandhir R (2022) Hydrogen sulfide attenuates hyperhomocysteinemia-induced blood-brain barrier permeability by inhibiting MMP-9. Int J Neurosci 132:1061\u20131071","journal-title":"Int J Neurosci"},{"key":"4968_CR85","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1093\/jn\/135.3.544","volume":"135","author":"H Lee","year":"2005","unstructured":"Lee H, Kim JM, Kim HJ, Lee I, Chang N (2005) Folic acid supplementation can reduce the endothelial damage in rat brain microvasculature due to hyperhomocysteinemia. J Nutr 135:544\u2013548","journal-title":"J Nutr"},{"key":"4968_CR86","doi-asserted-by":"publisher","first-page":"637","DOI":"10.3390\/brainsci10090637","volume":"10","author":"E Dubchenko","year":"2020","unstructured":"Dubchenko E, Ivanov A, Spirina N et al (2020) Hyperhomocysteinemia and endothelial dysfunction in multiple sclerosis. Brain Sci 10:637","journal-title":"Brain Sci"},{"key":"4968_CR87","doi-asserted-by":"publisher","first-page":"867","DOI":"10.3390\/ijms20040867","volume":"20","author":"R Esse","year":"2019","unstructured":"Esse R, Barroso M, Tavares De Almeida I, Castro R (2019) The contribution of homocysteine metabolism disruption to endothelial dysfunction: state-of-the-art. Int J Mol Sci 20:867","journal-title":"Int J Mol Sci"},{"key":"4968_CR88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vph.2017.05.005","volume":"100","author":"MA Incalza","year":"2018","unstructured":"Incalza MA, D\u2019oria R, Natalicchio A, Perrini S, Laviola L, Giorgino F (2018) Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. Vascul Pharmacol 100:1\u201319","journal-title":"Vascul Pharmacol"},{"key":"4968_CR89","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1210\/en.2006-1709","volume":"148","author":"J Cheng","year":"2007","unstructured":"Cheng J, Cui R, Chen CH, Du J (2007) Oxidized low-density lipoprotein stimulates p53-dependent activation of proapoptotic Bax leading to apoptosis of differentiated endothelial progenitor cells. Endocrinology 148:2085\u20132094","journal-title":"Endocrinology"},{"key":"4968_CR90","doi-asserted-by":"publisher","first-page":"C135","DOI":"10.1152\/ajpcell.00136.2018","volume":"316","author":"C Yang","year":"2019","unstructured":"Yang C, Hawkins KE, Dore S, Candelario-Jalil E (2019) Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke. Am J Physiol Cell Physiol 316:C135\u2013C153","journal-title":"Am J Physiol Cell Physiol"},{"key":"4968_CR91","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1007\/s12035-015-9212-4","volume":"53","author":"PK Kamat","year":"2016","unstructured":"Kamat PK, Kyles P, Kalani A, Tyagi N (2016) Hydrogen sulfide ameliorates homocysteine-induced Alzheimer\u2019s disease-like pathology, blood-brain barrier disruption, and synaptic disorder. Mol Neurobiol 53:2451\u20132467","journal-title":"Mol Neurobiol"},{"key":"4968_CR92","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1002\/cbf.3108","volume":"33","author":"LM Li","year":"2015","unstructured":"Li LM, Zheng B, Zhang RN et al (2015) Chinese medicine Tongxinluo increases tight junction protein levels by inducing KLF5 expression in microvascular endothelial cells. Cell Biochem Funct 33:226\u2013234","journal-title":"Cell Biochem Funct"},{"key":"4968_CR93","doi-asserted-by":"publisher","first-page":"7209","DOI":"10.1080\/21655979.2022.2037953","volume":"13","author":"S Shen","year":"2022","unstructured":"Shen S, Wang J, Zhao Q, Hu Q (2022) The protective effects of butorphanol tartrate against homocysteine-induced blood-brain barrier dysfunction. Bioengineered 13:7209\u20137220","journal-title":"Bioengineered"},{"key":"4968_CR94","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1096\/fj.05-3724fje","volume":"19","author":"Y Enokido","year":"2005","unstructured":"Enokido Y, Suzuki E, Iwasawa K, Namekata K, Okazawa H, Kimura H (2005) Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia\/astrocyte lineage of developing mouse CNS. FASEB J 19:1854\u20131856","journal-title":"FASEB J"},{"key":"4968_CR95","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1007\/s10571-015-0325-0","volume":"36","author":"L Wan","year":"2016","unstructured":"Wan L, Sun Y, Zhang F, Ren Y (2016) Low-dose homocystine enhances proliferation and migration of Bv2 microglia cells. Cell Mol Neurobiol 36:1279\u20131289","journal-title":"Cell Mol Neurobiol"},{"key":"4968_CR96","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.brainres.2010.07.071","volume":"1355","author":"SO Loureiro","year":"2010","unstructured":"Loureiro SO, Romao L, Alves T et al (2010) Homocysteine induces cytoskeletal remodeling and production of reactive oxygen species in cultured cortical astrocytes. Brain Res 1355:151\u2013164","journal-title":"Brain Res"},{"key":"4968_CR97","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1161\/STROKEAHA.115.009136","volume":"46","author":"Z Shi","year":"2015","unstructured":"Shi Z, Guan Y, Huo YR et al (2015) Elevated total homocysteine levels in acute ischemic stroke are associated with long-term mortality. Stroke 46:2419\u20132425","journal-title":"Stroke"},{"key":"4968_CR98","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.05.008","volume":"25","author":"E Kumral","year":"2016","unstructured":"Kumral E, Saruhan G, Aktert D, Orman M (2016) Association of hyperhomocysteinemia with stroke recurrence after initial stroke. J Stroke Cerebrovasc Dis 25:2047\u20132054","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"4968_CR99","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1007\/s11064-012-0752-y","volume":"37","author":"M Kovalska","year":"2012","unstructured":"Kovalska M, Kovalska L, Pavlikova M et al (2012) Intracellular signaling MAPK pathway after cerebral ischemia-reperfusion injury. Neurochem Res 37:1568\u20131577","journal-title":"Neurochem Res"},{"key":"4968_CR100","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1007\/s12640-015-9587-z","volume":"29","author":"J Kolling","year":"2016","unstructured":"Kolling J, Scherer EB, Siebert C et al (2016) Severe hyperhomocysteinemia decreases respiratory enzyme and Na(+)-K(+) ATPase activities, and leads to mitochondrial alterations in rat amygdala. Neurotox Res 29:408\u2013418","journal-title":"Neurotox Res"},{"key":"4968_CR101","first-page":"887","volume":"66","author":"M Kovalska","year":"2015","unstructured":"Kovalska M, Kovalska L, Tothova B, Mahmood S, Adamkov M, Lehotsky J (2015) Combination of hyperhomocysteinemia and ischemic tolerance in experimental model of global ischemia in rats. J Physiol Pharmacol 66:887\u2013897","journal-title":"J Physiol Pharmacol"},{"key":"4968_CR102","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1161\/STROKEAHA.113.004099","volume":"45","author":"HM Kwon","year":"2014","unstructured":"Kwon HM, Lee YS, Bae HJ, Kang DW (2014) Homocysteine as a predictor of early neurological deterioration in acute ischemic stroke. Stroke 45:871\u2013873","journal-title":"Stroke"},{"key":"4968_CR103","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s11011-006-9029-y","volume":"21","author":"B Tagliari","year":"2006","unstructured":"Tagliari B, Zamin LL, Salbego CG, Netto CA, Wyse AT (2006) Homocysteine increases neuronal damage in hippocampal slices receiving oxygen and glucose deprivation. Metab Brain Dis 21:273\u2013278","journal-title":"Metab Brain Dis"},{"key":"4968_CR104","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.bbrc.2018.10.140","volume":"506","author":"DA Sibarov","year":"2018","unstructured":"Sibarov DA, Giniatullin R, Antonov SM (2018) High sensitivity of cerebellar neurons to homocysteine is determined by expression of GluN2C and GluN2D subunits of NMDA receptors. Biochem Biophys Res Commun 506:648\u2013652","journal-title":"Biochem Biophys Res Commun"},{"key":"4968_CR105","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1002\/neu.480230915","volume":"23","author":"DW Choi","year":"1992","unstructured":"Choi DW (1992) Excitotoxic cell death. J Neurobiol 23:1261\u20131276","journal-title":"J Neurobiol"},{"key":"4968_CR106","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1016\/j.neuron.2022.03.021","volume":"110","author":"P Zong","year":"2022","unstructured":"Zong P, Feng J, Yue Z et al (2022) Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury. Neuron 110:1944\u20131958 (e1948)","journal-title":"Neuron"},{"key":"4968_CR107","doi-asserted-by":"publisher","first-page":"6920","DOI":"10.1523\/JNEUROSCI.20-18-06920.2000","volume":"20","author":"Ii Kruman","year":"2000","unstructured":"Kruman Ii, Culmsee C, Chan SL et al (2000) Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci 20:6920\u20136926","journal-title":"J Neurosci"},{"key":"4968_CR108","first-page":"117","volume":"216","author":"WK Kim","year":"1996","unstructured":"Kim WK, Pae YS (1996) Involvement of N-methyl-d-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture. Neurosci Lett 216:117\u2013120","journal-title":"Neurosci Lett"},{"key":"4968_CR109","doi-asserted-by":"publisher","first-page":"5923","DOI":"10.1073\/pnas.94.11.5923","volume":"94","author":"SA Lipton","year":"1997","unstructured":"Lipton SA, Kim WK, Choi YB et al (1997) Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A 94:5923\u20135928","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4968_CR110","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.brainres.2008.05.090","volume":"1226","author":"PK Ganguly","year":"2008","unstructured":"Ganguly PK, Maddaford TG, Edel AL, Karmin O, Smeda JS, Pierce GN (2008) Increased homocysteine-induced release of excitatory amino acids in the striatum of spontaneously hypertensive stroke-prone rats. Brain Res 1226:192\u2013198","journal-title":"Brain Res"},{"key":"4968_CR111","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.neubiorev.2018.04.005","volume":"90","author":"J Das","year":"2018","unstructured":"Das J, Rajanikant GK (2018) Post stroke depression: the sequelae of cerebral stroke. Neurosci Biobehav Rev 90:104\u2013114","journal-title":"Neurosci Biobehav Rev"},{"key":"4968_CR112","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1161\/STROKEAHA.111.679340","volume":"44","author":"L Ayerbe","year":"2013","unstructured":"Ayerbe L, Ayis S, Crichton S, Wolfe CD, Rudd AG (2013) The natural history of depression up to 15 years after stroke: the South London Stroke Register. Stroke 44:1105\u20131110","journal-title":"Stroke"},{"key":"4968_CR113","first-page":"56","volume":"2012","author":"MC Pascoe","year":"2012","unstructured":"Pascoe MC, Crewther SG, Carey LM, Noonan K, Crewther DP, Linden T (2012) Homocysteine as a potential biochemical marker for depression in elderly stroke survivors. Food Nutr Res 2012:56","journal-title":"Food Nutr Res"},{"key":"4968_CR114","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.cca.2018.01.011","volume":"479","author":"J Yin","year":"2018","unstructured":"Yin J, Zhong C, Zhu Z et al (2018) Elevated circulating homocysteine and high-sensitivity C-reactive protein jointly predicts post-stroke depression among Chinese patients with acute ischemic stroke. Clin Chim Acta 479:132\u2013137","journal-title":"Clin Chim Acta"},{"key":"4968_CR115","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1093\/ajcn\/59.5.1033","volume":"59","author":"JW Miller","year":"1994","unstructured":"Miller JW, Nadeau MR, Smith D, Selhub J (1994) Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats. Am J Clin Nutr 59:1033\u20131039","journal-title":"Am J Clin Nutr"},{"key":"4968_CR116","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.jad.2020.08.022","volume":"277","author":"H Zhou","year":"2020","unstructured":"Zhou H, Zhong X, Chen B et al (2020) Interactive effects of elevated homocysteine and late-life depression on cognitive impairment. J Affect Disord 277:212\u2013217","journal-title":"J Affect Disord"},{"key":"4968_CR117","doi-asserted-by":"publisher","first-page":"e3210","DOI":"10.1002\/brb3.3210","volume":"13","author":"H Zhou","year":"2023","unstructured":"Zhou H, Wang C, Wang W et al (2023) Lesion location and serum levels of homocysteine are associated with early-onset post-stroke depression in acute ischemic stroke. Brain Behav 13:e3210","journal-title":"Brain Behav"},{"key":"4968_CR118","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1007\/s12035-016-9799-0","volume":"54","author":"C Zhong","year":"2017","unstructured":"Zhong C, Xu T, Xu T et al (2017) Plasma homocysteine and prognosis of acute ischemic stroke: a gender-specific analysis From CATIS randomized clinical trial. Mol Neurobiol 54:2022\u20132030","journal-title":"Mol Neurobiol"},{"key":"4968_CR119","doi-asserted-by":"crossref","unstructured":"Jiang Z, Li M, Wang K, Duan H, Zhang B, Fang S (2025) Potential biomarkers of post-stroke cognitive impairment in Chinese population: a systematic review and meta-analysis. Mol Neurobiol","DOI":"10.1007\/s12035-025-04792-x"},{"key":"4968_CR120","doi-asserted-by":"publisher","first-page":"746","DOI":"10.3390\/ijms26020746","volume":"26","author":"H Jakubowski","year":"2025","unstructured":"Jakubowski H, Witucki L (2025) Homocysteine metabolites, endothelial dysfunction, and cardiovascular disease. Int J Mol Sci 26:746","journal-title":"Int J Mol Sci"},{"key":"4968_CR121","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3390\/jcm11020394","volume":"11","author":"MP Lauretta","year":"2022","unstructured":"Lauretta MP, Melotti RM, Sangermano C, George AM, Badenes R, Bilotta F (2022) homocysteine plasmatic concentration in brain-injured neurocritical care patients: systematic review of clinical evidence. J Clin Med 11:394","journal-title":"J Clin Med"},{"key":"4968_CR122","doi-asserted-by":"publisher","first-page":"600582","DOI":"10.3389\/fnsys.2020.600582","volume":"14","author":"S Huang","year":"2020","unstructured":"Huang S, Cai J, Tian Y (2020) The prognostic value of homocysteine in acute ischemic stroke patients: a systematic review and meta-analysis. Front Syst Neurosci 14:600582","journal-title":"Front Syst Neurosci"},{"key":"4968_CR123","doi-asserted-by":"publisher","first-page":"1451786","DOI":"10.3389\/fneur.2024.1451786","volume":"15","author":"M Wei","year":"2024","unstructured":"Wei M, Zhu X, Yang X, Shang J, Tong Q, Han Q (2024) Development and validation of a novel model to predict post-stroke cognitive impairment within 6 months after acute ischemic stroke. Front Neurol 15:1451786","journal-title":"Front Neurol"},{"key":"4968_CR124","doi-asserted-by":"publisher","first-page":"1465380","DOI":"10.3389\/fneph.2024.1465380","volume":"4","author":"X Hu","year":"2024","unstructured":"Hu X, Jiang Y (2024) The impact of SLCO1B1 polymorphisms on homocysteine concentrations: evidence for a stronger association in men. Front Nephrol 4:1465380","journal-title":"Front Nephrol"},{"key":"4968_CR125","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1161\/ATVBAHA.119.313741","volume":"40","author":"J Li","year":"2020","unstructured":"Li J, Wang Y, Li H et al (2020) Homocysteine level predicts response to dual antiplatelet in women with minor stroke or transient ischemic attack: subanalysis of the CHANCE trial. Arterioscler Thromb Vasc Biol 40:839\u2013846","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4968_CR126","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1161\/01.STR.0000069017.78624.37","volume":"34","author":"G Boysen","year":"2003","unstructured":"Boysen G, Brander T, Christensen H, Gideon R, Truelsen T (2003) Homocysteine and risk of recurrent stroke. Stroke 34:1258\u20131261","journal-title":"Stroke"},{"key":"4968_CR127","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1042\/CS20090142","volume":"118","author":"W Zhang","year":"2009","unstructured":"Zhang W, Sun K, Chen J et al (2009) High plasma homocysteine levels contribute to the risk of stroke recurrence and all-cause mortality in a large prospective stroke population. Clin Sci (Lond) 118:187\u2013194","journal-title":"Clin Sci (Lond)"},{"key":"4968_CR128","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.repc.2022.06.005","volume":"41","author":"RR Palma","year":"2022","unstructured":"Palma RR (2022) Homocysteinemia and vascular disease: where we stand in 2022. Rev Port Cardiol 41:821\u2013822","journal-title":"Rev Port Cardiol"},{"key":"4968_CR129","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1177\/09727531221124425","volume":"30","author":"M Ghose","year":"2023","unstructured":"Ghose M, Das M, Das R et al (2023) Homocysteine, vitamins B6, B12, and folate and the risk of ischemic and hemorrhagic stroke: a case-control study from Northeast India. Ann Neurosci 30:33\u201339","journal-title":"Ann Neurosci"},{"key":"4968_CR130","first-page":"e14958","volume":"13","author":"N Kataria","year":"2021","unstructured":"Kataria N, Yadav P, Kumar R et al (2021) Effect of vitamin B6, B9, and B12 supplementation on homocysteine level and cardiovascular outcomes in stroke patients: a meta-analysis of randomized controlled Trials. Cureus 13:e14958","journal-title":"Cureus"},{"key":"4968_CR131","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1212\/WNL.0000000000004648","volume":"89","author":"X Huang","year":"2017","unstructured":"Huang X, Li Y, Li P et al (2017) Association between percent decline in serum total homocysteine and risk of first stroke. Neurology 89:2101\u20132107","journal-title":"Neurology"},{"key":"4968_CR132","doi-asserted-by":"crossref","unstructured":"Li Y, Huang T, Zheng Y, Muka T, Troup J, Hu FB (2016) Folic acid supplementation and the risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. J Am Heart Assoc 5:e003768","DOI":"10.1161\/JAHA.116.003768"},{"key":"4968_CR133","doi-asserted-by":"publisher","first-page":"690359","DOI":"10.3389\/fnut.2021.690359","volume":"8","author":"C Truitt","year":"2021","unstructured":"Truitt C, Hoff WD, Deole R (2021) Health functionalities of betaine in patients with homocystinuria. Front Nutr 8:690359","journal-title":"Front Nutr"},{"key":"4968_CR134","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.cca.2016.04.002","volume":"458","author":"T Kumar","year":"2016","unstructured":"Kumar T, Sharma GS, Singh LR (2016) Homocystinuria: therapeutic approach. Clin Chim Acta 458:55\u201362","journal-title":"Clin Chim Acta"},{"key":"4968_CR135","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.pediatrneurol.2013.08.021","volume":"50","author":"IS Ruhoy","year":"2014","unstructured":"Ruhoy IS, Merritt JL 2nd, Amlie-Lefond C (2014) Cystathionine beta-synthase deficiency heralded by cerebral sinus venous thrombosis and stroke. Pediatr Neurol 50:108\u2013111","journal-title":"Pediatr Neurol"},{"key":"4968_CR136","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1212\/01.WNL.0000042479.55406.B3","volume":"60","author":"PJ Kelly","year":"2003","unstructured":"Kelly PJ, Furie KL, Kistler JP et al (2003) Stroke in young patients with hyperhomocysteinemia due to cystathionine beta-synthase deficiency. Neurology 60:275\u2013279","journal-title":"Neurology"},{"key":"4968_CR137","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/emm.2006.77","volume":"38","author":"ES Park","year":"2006","unstructured":"Park ES, Oh HJ, Kruger WD, Jung SC, Lee JS (2006) Recombinant adeno-associated virus mediated gene transfer in a mouse model for homocystinuria. Exp Mol Med 38:652\u2013661","journal-title":"Exp Mol Med"},{"key":"4968_CR138","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1089\/hum.2019.014","volume":"30","author":"HO Lee","year":"2019","unstructured":"Lee HO, Gallego-Villar L, Grisch-Chan HM, Haberle J, Thony B, Kruger WD (2019) Treatment of cystathionine beta-synthase deficiency in mice using a minicircle-based naked DNA vector. Hum Gene Ther 30:1093\u20131100","journal-title":"Hum Gene Ther"},{"key":"4968_CR139","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.ab.2016.06.002","volume":"508","author":"H Jakubowski","year":"2016","unstructured":"Jakubowski H (2016) Quantification of urinary S- and N-homocysteinylated protein and homocysteine-thiolactone in mice. Anal Biochem 508:118\u2013123","journal-title":"Anal Biochem"},{"key":"4968_CR140","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1007\/s12035-018-1141-6","volume":"56","author":"P Narne","year":"2019","unstructured":"Narne P, Pandey V, Phanithi PB (2019) Role of nitric oxide and hydrogen sulfide in ischemic stroke and the emergent epigenetic underpinnings. Mol Neurobiol 56:1749\u20131769","journal-title":"Mol Neurobiol"},{"key":"4968_CR141","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1002\/jcp.27120","volume":"234","author":"N Nath","year":"2019","unstructured":"Nath N, Prasad HK, Kumar M (2019) Cerebroprotective effects of hydrogen sulfide in homocysteine-induced neurovascular permeability: involvement of oxidative stress, arginase, and matrix metalloproteinase-9. J Cell Physiol 234:3007\u20133019","journal-title":"J Cell Physiol"},{"key":"4968_CR142","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1080\/00207454.2020.1782904","volume":"131","author":"L Lv","year":"2021","unstructured":"Lv L, Xi HP, Huang JC, Zhou XY (2021) LncRNA SNHG1 alleviated apoptosis and inflammation during ischemic stroke by targeting miR-376a and modulating CBS\/H(2)S pathway. Int J Neurosci 131:1162\u20131172","journal-title":"Int J Neurosci"},{"key":"4968_CR143","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.bbi.2017.07.156","volume":"66","author":"M Zhang","year":"2017","unstructured":"Zhang M, Wu X, Xu Y et al (2017) The cystathionine beta-synthase\/hydrogen sulfide pathway contributes to microglia-mediated neuroinflammation following cerebral ischemia. Brain Behav Immun 66:332\u2013346","journal-title":"Brain Behav Immun"},{"key":"4968_CR144","doi-asserted-by":"publisher","first-page":"177079","DOI":"10.1016\/j.ejphar.2024.177079","volume":"985","author":"F Fang","year":"2024","unstructured":"Fang F, Guan YN, Zhong MJ, Wen JY, Chen ZW (2024) H(2)S protects rat cerebral ischemia-reperfusion injury by inhibiting expression and activation of hippocampal ROCK(2) at the Thr436 and Ser575 sites. Eur J Pharmacol 985:177079","journal-title":"Eur J Pharmacol"},{"key":"4968_CR145","doi-asserted-by":"publisher","first-page":"154666","DOI":"10.1016\/j.phymed.2023.154666","volume":"111","author":"X Yin","year":"2023","unstructured":"Yin X, Liu B, Ding Y et al (2023) Total flavones of rhododendron induce the transformation of A1\/A2 astrocytes via promoting the release of CBS-produced H(2)S. Phytomedicine 111:154666","journal-title":"Phytomedicine"},{"key":"4968_CR146","doi-asserted-by":"publisher","first-page":"653032","DOI":"10.3389\/fgene.2021.653032","volume":"12","author":"W Liu","year":"2021","unstructured":"Liu W, Zhang L, Li S et al (2021) A Mendelian randomization study of plasma homocysteine levels and cerebrovascular and neurodegenerative diseases. Front Genet 12:653032","journal-title":"Front Genet"},{"key":"4968_CR147","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1136\/bmj.325.7374.1202","volume":"325","author":"DS Wald","year":"2002","unstructured":"Wald DS, Law M, Morris JK (2002) Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 325:1202","journal-title":"BMJ"},{"key":"4968_CR148","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","volume":"288","author":"SC Homocysteine","year":"2002","unstructured":"Homocysteine SC (2002) Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 288:2015\u20132022","journal-title":"JAMA"},{"key":"4968_CR149","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s12916-021-01977-8","volume":"19","author":"S Yuan","year":"2021","unstructured":"Yuan S, Mason AM, Carter P, Burgess S, Larsson SC (2021) Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study. BMC Med 19:97","journal-title":"BMC Med"},{"key":"4968_CR150","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.jhep.2022.06.033","volume":"77","author":"M Tripathi","year":"2022","unstructured":"Tripathi M, Singh BK, Zhou J et al (2022) Vitamin B(12) and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation. J Hepatol 77:1246\u20131255","journal-title":"J Hepatol"},{"key":"4968_CR151","doi-asserted-by":"publisher","first-page":"2960","DOI":"10.3390\/nu14142960","volume":"14","author":"J Poole","year":"2022","unstructured":"Poole J, Jasbi P, Pascual AS et al (2022) Ischemic stroke and dietary vitamin B12 deficiency in old-aged females: impaired motor function, increased ischemic damage size, and changed metabolite profiles in brain and cecum tissue. Nutrients 14:2960","journal-title":"Nutrients"},{"key":"4968_CR152","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1212\/CPJ.0000000000000248","volume":"7","author":"G Zacharia","year":"2017","unstructured":"Zacharia G, Shani D, Ortiz RA (2017) Recurrent stroke in a patient with vitamin B(12) deficiency and MTHFR mutation. Neurol Clin Pract 7:e1\u2013e4","journal-title":"Neurol Clin Pract"},{"key":"4968_CR153","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1161\/STROKEAHA.108.523431","volume":"40","author":"B Pieters","year":"2009","unstructured":"Pieters B, Staals J, Knottnerus I et al (2009) Periventricular white matter lucencies relate to low vitamin B12 levels in patients with small vessel stroke. Stroke 40:1623\u20131626","journal-title":"Stroke"},{"key":"4968_CR154","doi-asserted-by":"publisher","first-page":"5489057","DOI":"10.1155\/2017\/5489057","volume":"2017","author":"M Markisic","year":"2017","unstructured":"Markisic M, Pavlovic AM, Pavlovic DM (2017) The impact of homocysteine, vitamin B12, and vitamin D Levels on functional outcome after first-ever ischaemic stroke. Biomed Res Int 2017:5489057","journal-title":"Biomed Res Int"},{"key":"4968_CR155","doi-asserted-by":"publisher","first-page":"9914298","DOI":"10.1155\/2021\/9914298","volume":"2021","author":"OJ Kweon","year":"2021","unstructured":"Kweon OJ, Lim YK, Lee MK, Kim HR (2021) Clinical utility of serum holotranscobalamin measurements in patients with first-ever ischemic stroke. Dis Markers 2021:9914298","journal-title":"Dis Markers"},{"key":"4968_CR156","first-page":"CD006612","volume":"8","author":"AJ Marti-Carvajal","year":"2017","unstructured":"Marti-Carvajal AJ, Sola I, Lathyris D, Dayer M (2017) Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev 8:CD006612","journal-title":"Cochrane Database Syst Rev"},{"key":"4968_CR157","doi-asserted-by":"publisher","first-page":"17","DOI":"10.7196\/SAMJ.2024.v114i1.1477","volume":"114","author":"N Letete","year":"2023","unstructured":"Letete N, Vaz D, Malishi PH, Pogieter JJ, Rheeder P (2023) Recurrent venous thrombosis - an unusual first presentation of autoimmune polyendocrinopathy syndrome type 3B. S Afr Med J 114:17\u201321","journal-title":"S Afr Med J"},{"issue":"Suppl 2","key":"4968_CR158","doi-asserted-by":"publisher","first-page":"S112","DOI":"10.1111\/j.1753-4887.2010.00346.x","volume":"68","author":"J Selhub","year":"2010","unstructured":"Selhub J, Troen A, Rosenberg IH (2010) B vitamins and the aging brain. Nutr Rev 68(Suppl 2):S112-118","journal-title":"Nutr Rev"},{"key":"4968_CR159","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.3390\/nu14071412","volume":"14","author":"W Herrmann","year":"2022","unstructured":"Herrmann W, Herrmann M (2022) The controversial role of HCY and vitamin B deficiency in cardiovascular diseases. Nutrients 14:1412","journal-title":"Nutrients"},{"key":"4968_CR160","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1093\/brain\/awh023","volume":"127","author":"A Hassan","year":"2004","unstructured":"Hassan A, Hunt BJ, O\u2019sullivan M et al (2004) Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Brain 127:212\u2013219","journal-title":"Brain"},{"key":"4968_CR161","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/S1474-4422(07)70219-3","volume":"6","author":"JD Spence","year":"2007","unstructured":"Spence JD (2007) Homocysteine-lowering therapy: a role in stroke prevention? Lancet Neurol 6:830\u2013838","journal-title":"Lancet Neurol"},{"key":"4968_CR162","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.archger.2018.07.019","volume":"79","author":"CW Wong","year":"2018","unstructured":"Wong CW, Leung CS, Leung CP, Cheng JN (2018) Association of metformin use with vitamin B(12) deficiency in the institutionalized elderly. Arch Gerontol Geriatr 79:57\u201362","journal-title":"Arch Gerontol Geriatr"},{"key":"4968_CR163","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s12264-009-0224-9","volume":"25","author":"YH Wang","year":"2009","unstructured":"Wang YH, Yan F, Zhang WB et al (2009) An investigation of vitamin B12 deficiency in elderly inpatients in neurology department. Neurosci Bull 25:209\u2013215","journal-title":"Neurosci Bull"},{"key":"4968_CR164","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1515\/CCLM.2007.325","volume":"45","author":"JD Spence","year":"2007","unstructured":"Spence JD (2007) Perspective on the efficacy analysis of the Vitamin Intervention for Stroke Prevention trial. Clin Chem Lab Med 45:1582\u20131585","journal-title":"Clin Chem Lab Med"},{"key":"4968_CR165","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1159\/000071002","volume":"16","author":"M Lehmann","year":"2003","unstructured":"Lehmann M, Regland B, Blennow K, Gottfries CG (2003) Vitamin B12-B6-folate treatment improves blood-brain barrier function in patients with hyperhomocysteinaemia and mild cognitive impairment. Dement Geriatr Cogn Disord 16:145\u2013150","journal-title":"Dement Geriatr Cogn Disord"},{"key":"4968_CR166","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1042\/bj20030059","volume":"374","author":"E Gianazza","year":"2003","unstructured":"Gianazza E, Veber D, Eberini I et al (2003) Cobalamin (vitamin B12)-deficiency-induced changes in the proteome of rat cerebrospinal fluid. Biochem J 374:239\u2013246","journal-title":"Biochem J"},{"key":"4968_CR167","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3892\/etm.2021.9914","volume":"21","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Wang L, Li X, Geng J (2021) Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats. Exp Ther Med 21:483","journal-title":"Exp Ther Med"},{"key":"4968_CR168","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1001\/jama.288.8.973","volume":"288","author":"G Schnyder","year":"2002","unstructured":"Schnyder G, Roffi M, Flammer Y, Pin R, Hess OM (2002) Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial. JAMA 288:973\u2013979","journal-title":"JAMA"},{"key":"4968_CR169","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1001\/jama.291.5.565","volume":"291","author":"JF Toole","year":"2004","unstructured":"Toole JF, Malinow MR, Chambless LE et al (2004) Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 291:565\u2013575","journal-title":"JAMA"},{"key":"4968_CR170","doi-asserted-by":"publisher","first-page":"112617","DOI":"10.1016\/j.celrep.2023.112617","volume":"42","author":"L Li","year":"2023","unstructured":"Li L, Cheng SQ, Sun YQ et al (2023) Resolvin D1 reprograms energy metabolism to promote microglia to phagocytize neutrophils after ischemic stroke. Cell Rep 42:112617","journal-title":"Cell Rep"},{"key":"4968_CR171","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1007\/s12035-018-1169-7","volume":"56","author":"K Bavarsad","year":"2019","unstructured":"Bavarsad K, Barreto GE, Hadjzadeh MA, Sahebkar A (2019) Protective effects of curcumin against ischemia-reperfusion injury in the nervous system. Mol Neurobiol 56:1391\u20131404","journal-title":"Mol Neurobiol"},{"key":"4968_CR172","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/jcbfm.1992.4","volume":"12","author":"J Folbergrova","year":"1992","unstructured":"Folbergrova J, Memezawa H, Smith ML, Siesjo BK (1992) Focal and perifocal changes in tissue energy state during middle cerebral artery occlusion in normo- and hyperglycemic rats. J Cereb Blood Flow Metab 12:25\u201333","journal-title":"J Cereb Blood Flow Metab"},{"key":"4968_CR173","doi-asserted-by":"publisher","first-page":"4132","DOI":"10.1007\/s12035-023-03329-4","volume":"60","author":"I Korczowska-Lacka","year":"2023","unstructured":"Korczowska-Lacka I, Hurla M, Banaszek N et al (2023) Selected biomarkers of oxidative stress and energy metabolism disorders in neurological diseases. Mol Neurobiol 60:4132\u20134149","journal-title":"Mol Neurobiol"},{"key":"4968_CR174","doi-asserted-by":"publisher","first-page":"4297","DOI":"10.7150\/thno.96375","volume":"14","author":"XY Xiong","year":"2024","unstructured":"Xiong XY, Pan XR, Luo XX et al (2024) Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation. Theranostics 14:4297\u20134317","journal-title":"Theranostics"},{"key":"4968_CR175","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.neuroscience.2021.11.035","volume":"481","author":"K Yamagata","year":"2022","unstructured":"Yamagata K (2022) Lactate supply from astrocytes to neurons and its role in ischemic stroke-induced neurodegeneration. Neuroscience 481:219\u2013231","journal-title":"Neuroscience"},{"key":"4968_CR176","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13041-018-0357-8","volume":"11","author":"QJ Wu","year":"2018","unstructured":"Wu QJ, Tymianski M (2018) Targeting NMDA receptors in stroke: new hope in neuroprotection. Mol Brain 11:15","journal-title":"Mol Brain"},{"key":"4968_CR177","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1177\/0271678X15606721","volume":"36","author":"J Castillo","year":"2016","unstructured":"Castillo J, Loza MI, Mirelman D et al (2016) A novel mechanism of neuroprotection: blood glutamate grabber. J Cereb Blood Flow Metab 36:292\u2013301","journal-title":"J Cereb Blood Flow Metab"},{"key":"4968_CR178","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40035-021-00278-7","volume":"11","author":"M Verma","year":"2022","unstructured":"Verma M, Lizama BN, Chu CT (2022) Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration. Transl Neurodegener 11:3","journal-title":"Transl Neurodegener"},{"key":"4968_CR179","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.coph.2017.07.014","volume":"35","author":"D Amantea","year":"2017","unstructured":"Amantea D, Bagetta G (2017) Excitatory and inhibitory amino acid neurotransmitters in stroke: from neurotoxicity to ischemic tolerance. Curr Opin Pharmacol 35:111\u2013119","journal-title":"Curr Opin Pharmacol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-04968-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-04968-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-04968-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:03:11Z","timestamp":1759996991000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-04968-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,6]]},"references-count":179,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["4968"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-04968-5","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,6]]},"assertion":[{"value":"2 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}