{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:11:55Z","timestamp":1793236315332,"version":"4.5.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T00:00:00Z","timestamp":1747440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T00:00:00Z","timestamp":1747440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Program from Ministry of Science and Technology","award":["2018YFC1707800"],"award-info":[{"award-number":["2018YFC1707800"]}]},{"name":"Program from Ministry of Science and Technology","award":["2018YFC1707800"],"award-info":[{"award-number":["2018YFC1707800"]}]},{"name":"Program from Ministry of Science and Technology","award":["2018YFC1707800"],"award-info":[{"award-number":["2018YFC1707800"]}]},{"name":"Program from Ministry of Science and Technology","award":["2018YFC1707800"],"award-info":[{"award-number":["2018YFC1707800"]}]},{"name":"Program from Ministry of Science and Technology","award":["2018YFC1707800"],"award-info":[{"award-number":["2018YFC1707800"]}]},{"name":"Program from Ministry of Science and Technology","award":["2018YFC1707800"],"award-info":[{"award-number":["2018YFC1707800"]}]},{"name":"Program from Ministry of Science and Technology","award":["2018YFC1707800"],"award-info":[{"award-number":["2018YFC1707800"]}]},{"name":"Program from Ministry of Science and Technology","award":["2018YFC1707800"],"award-info":[{"award-number":["2018YFC1707800"]}]},{"name":"Program from Ministry of Science and Technology","award":["2018YFC1707800"],"award-info":[{"award-number":["2018YFC1707800"]}]},{"name":"Program from Ministry of Science and Technology","award":["2018YFC1707800"],"award-info":[{"award-number":["2018YFC1707800"]}]},{"name":"Program from Ministry of Science and Technology","award":["2018YFC1707800"],"award-info":[{"award-number":["2018YFC1707800"]}]},{"name":"Program from Ministry of Science and Technology","award":["2018YFC1707800"],"award-info":[{"award-number":["2018YFC1707800"]}]},{"name":"The General Program of Natural Science Foundation of Hunan Province, China","award":["2019JJ40217"],"award-info":[{"award-number":["2019JJ40217"]}]},{"name":"The General Program of Natural Science Foundation of Hunan Province, China","award":["2019JJ40217"],"award-info":[{"award-number":["2019JJ40217"]}]},{"name":"The General Program of Natural Science Foundation of Hunan Province, China","award":["2019JJ40217"],"award-info":[{"award-number":["2019JJ40217"]}]},{"name":"The General Program of Natural Science Foundation of Hunan Province, China","award":["2019JJ40217"],"award-info":[{"award-number":["2019JJ40217"]}]},{"name":"The General Program of Natural Science Foundation of Hunan Province, China","award":["2019JJ40217"],"award-info":[{"award-number":["2019JJ40217"]}]},{"name":"The General Program of Natural Science Foundation of Hunan Province, China","award":["2019JJ40217"],"award-info":[{"award-number":["2019JJ40217"]}]},{"name":"The General Program of Natural Science Foundation of Hunan Province, China","award":["2019JJ40217"],"award-info":[{"award-number":["2019JJ40217"]}]},{"name":"The General Program of Natural Science Foundation of Hunan Province, China","award":["2019JJ40217"],"award-info":[{"award-number":["2019JJ40217"]}]},{"name":"The General Program of Natural Science Foundation of Hunan Province, China","award":["2019JJ40217"],"award-info":[{"award-number":["2019JJ40217"]}]},{"name":"The General Program of Natural Science Foundation of Hunan Province, China","award":["2019JJ40217"],"award-info":[{"award-number":["2019JJ40217"]}]},{"name":"The General Program of Natural Science Foundation of Hunan Province, China","award":["2019JJ40217"],"award-info":[{"award-number":["2019JJ40217"]}]},{"name":"The General Program of Natural Science Foundation of Hunan Province, China","award":["2019JJ40217"],"award-info":[{"award-number":["2019JJ40217"]}]},{"name":"General Issues of Hunan Provincial Health Commission","award":["D202304079413"],"award-info":[{"award-number":["D202304079413"]}]},{"name":"General Issues of Hunan Provincial Health Commission","award":["D202304079413"],"award-info":[{"award-number":["D202304079413"]}]},{"name":"General Issues of Hunan Provincial Health Commission","award":["D202304079413"],"award-info":[{"award-number":["D202304079413"]}]},{"name":"General Issues of Hunan Provincial Health Commission","award":["D202304079413"],"award-info":[{"award-number":["D202304079413"]}]},{"name":"General Issues of Hunan Provincial Health Commission","award":["D202304079413"],"award-info":[{"award-number":["D202304079413"]}]},{"name":"General Issues of Hunan Provincial Health Commission","award":["D202304079413"],"award-info":[{"award-number":["D202304079413"]}]},{"name":"General Issues of Hunan Provincial Health Commission","award":["D202304079413"],"award-info":[{"award-number":["D202304079413"]}]},{"name":"General Issues of Hunan Provincial Health Commission","award":["D202304079413"],"award-info":[{"award-number":["D202304079413"]}]},{"name":"General Issues of Hunan Provincial Health Commission","award":["D202304079413"],"award-info":[{"award-number":["D202304079413"]}]},{"name":"General Issues of Hunan Provincial Health Commission","award":["D202304079413"],"award-info":[{"award-number":["D202304079413"]}]},{"name":"General Issues of Hunan Provincial Health Commission","award":["D202304079413"],"award-info":[{"award-number":["D202304079413"]}]},{"name":"General Issues of Hunan Provincial Health Commission","award":["D202304079413"],"award-info":[{"award-number":["D202304079413"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s12035-025-04984-5","type":"journal-article","created":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T01:06:09Z","timestamp":1747443969000},"page":"12270-12279","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analgesic Effects of Acupressure on Jing-jiaji Acupoints in a Rat Model of Cervical Spondylotic Radiculopathy"],"prefix":"10.1007","volume":"62","author":[{"given":"Shang-Hong","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Yao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ni","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Ying","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Fang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Yao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Di","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Yu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,17]]},"reference":[{"issue":"8","key":"4984_CR1","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1177\/21925682221075290","volume":"12","author":"H Luyao","year":"2022","unstructured":"Luyao H et al (2022) Management of Cervical Spondylotic Radiculopathy: A Systematic review. Global Spine J 12(8):1912\u20131924","journal-title":"Global Spine J"},{"key":"4984_CR2","doi-asserted-by":"publisher","first-page":"1140531","DOI":"10.3389\/fnagi.2023.1140531","volume":"15","author":"J Yang","year":"2023","unstructured":"Yang J et al (2023) Qihuang needle therapy in senile cervical spondylotic radiculopathy. Front Aging Neurosci 15:1140531","journal-title":"Front Aging Neurosci"},{"issue":"20","key":"4984_CR3","doi-asserted-by":"publisher","first-page":"e20216","DOI":"10.1097\/MD.0000000000020216","volume":"99","author":"S Yao","year":"2020","unstructured":"Yao S et al (2020) Treatment of cervical spondylotic radiculopathy with posterior percutaneous endoscopic cervical discectomy: Short-term outcomes of 24 cases. Medicine (Baltimore) 99(20):e20216","journal-title":"Medicine (Baltimore)"},{"key":"4984_CR4","doi-asserted-by":"publisher","first-page":"1003821","DOI":"10.3389\/fnmol.2022.1003821","volume":"15","author":"IJ Lutke Schipholt","year":"2022","unstructured":"Lutke Schipholt IJ et al (2022) Systemic neuroimmune responses in people with non-specific neck pain and cervical radiculopathy, and associations with clinical, psychological, and lifestyle factors. Front Mol Neurosci 15:1003821","journal-title":"Front Mol Neurosci"},{"issue":"48","key":"4984_CR5","doi-asserted-by":"publisher","first-page":"e17974","DOI":"10.1097\/MD.0000000000017974","volume":"98","author":"G Zuo","year":"2019","unstructured":"Zuo G et al (2019) Assessment of the efficacy of acupuncture and chiropractic on treating Cervical spondylosis radiculopathy: A systematic review and meta-analysis. Medicine (Baltimore) 98(48):e17974","journal-title":"Medicine (Baltimore)"},{"key":"4984_CR6","doi-asserted-by":"publisher","first-page":"940343","DOI":"10.3389\/fnins.2022.940343","volume":"16","author":"X Ma","year":"2022","unstructured":"Ma X et al (2022) Potential mechanisms of acupuncture for neuropathic pain based on somatosensory system. Front Neurosci 16:940343","journal-title":"Front Neurosci"},{"key":"4984_CR7","doi-asserted-by":"publisher","first-page":"8041820","DOI":"10.1155\/2018\/8041820","volume":"2018","author":"SW Jiang","year":"2018","unstructured":"Jiang SW, Lin YW, Hsieh CL (2018) Electroacupuncture at Hua Tuo Jia Ji Acupoints Reduced Neuropathic Pain and Increased GABA(A) Receptors in Rat Spinal Cord. Evid Based Complement Alternat Med 2018:8041820","journal-title":"Evid Based Complement Alternat Med"},{"key":"4984_CR8","doi-asserted-by":"publisher","first-page":"7191","DOI":"10.2147\/JIR.S341581","volume":"14","author":"N Li","year":"2021","unstructured":"Li N et al (2021) The Anti-Inflammatory Actions and Mechanisms of Acupuncture from Acupoint to Target Organs via Neuro-Immune Regulation. J Inflamm Res 14:7191\u20137224","journal-title":"J Inflamm Res"},{"issue":"7","key":"4984_CR9","doi-asserted-by":"publisher","first-page":"e026904","DOI":"10.1136\/bmjopen-2018-026904","volume":"9","author":"M Sun","year":"2019","unstructured":"Sun M et al (2019) Acupuncture for chronic neck pain with sensitive points: study protocol for a multicentre randomised controlled trial. BMJ Open 9(7):e026904","journal-title":"BMJ Open"},{"issue":"2","key":"4984_CR10","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.pmn.2012.12.005","volume":"15","author":"YW Chen","year":"2014","unstructured":"Chen YW, Wang HH (2014) The effectiveness of acupressure on relieving pain: a systematic review. Pain Manag Nurs 15(2):539\u2013550","journal-title":"Pain Manag Nurs"},{"key":"4984_CR11","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.2147\/JPR.S415111","volume":"16","author":"P Yang","year":"2023","unstructured":"Yang P et al (2023) Electroacupuncture Attenuates Neuropathic Pain in a Rat Model of Cervical Spondylotic Radiculopathy: Involvement of Spinal Cord Synaptic Plasticity. J Pain Res 16:2447\u20132460","journal-title":"J Pain Res"},{"key":"4984_CR12","doi-asserted-by":"publisher","first-page":"3945","DOI":"10.2147\/JPR.S419927","volume":"16","author":"T Shi","year":"2023","unstructured":"Shi T et al (2023) Acupuncture Relieves Cervical Spondylosis Radiculopathy by Regulating Spinal Microglia Activation Through MAPK Signaling Pathway in Rats. J Pain Res 16:3945\u20133960","journal-title":"J Pain Res"},{"key":"4984_CR13","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.3389\/fphar.2020.01139","volume":"11","author":"YZ Zhang","year":"2020","unstructured":"Zhang YZ et al (2020) The Protective Effect and Mechanism of Dexmedetomidine on Diabetic Peripheral Neuropathy in Rats. Front Pharmacol 11:1139","journal-title":"Front Pharmacol"},{"issue":"2","key":"4984_CR14","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/os.13951","volume":"16","author":"T Liu","year":"2024","unstructured":"Liu T et al (2024) Comparison of Cervical Sagittal Parameters among Patients with Neck Pain and Patients with Cervical Spondylotic Radiculopathy and Cervical Spondylotic Myelopathy. Orthop Surg 16(2):329\u2013336","journal-title":"Orthop Surg"},{"issue":"10","key":"4984_CR15","doi-asserted-by":"publisher","first-page":"e3177","DOI":"10.1002\/brb3.3177","volume":"13","author":"H Su","year":"2023","unstructured":"Su H et al (2023) Electroacupuncture ameliorates pain in cervical spondylotic radiculopathy rat by inhibiting the CaMKII\/CREB\/BDNF signaling pathway and regulating spinal synaptic plasticity. Brain Behav 13(10):e3177","journal-title":"Brain Behav"},{"issue":"5","key":"4984_CR16","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1177\/0964528420961398","volume":"39","author":"CT Susana","year":"2021","unstructured":"Susana CT et al (2021) Effectiveness of self-applied acupressure for cervical pain of benign origin (EDIDO-CUH): a randomized controlled clinical trial. Acupunct Med 39(5):441\u2013451","journal-title":"Acupunct Med"},{"key":"4984_CR17","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1186\/1745-6215-14-360","volume":"14","author":"ZR Sun","year":"2013","unstructured":"Sun ZR, Yue JH, Zhang QH (2013) Electroacupuncture at Jing-jiaji points for neck pain caused by cervical spondylosis: a study protocol for a randomized controlled pilot trial. Trials 14:360","journal-title":"Trials"},{"issue":"3","key":"4984_CR18","doi-asserted-by":"publisher","first-page":"337","DOI":"10.4142\/jvs.2016.17.3.337","volume":"17","author":"CM Liu","year":"2016","unstructured":"Liu CM, Chang FC, Lin CT (2016) Retrospective study of the clinical effects of acupuncture on cervical neurological diseases in dogs. J Vet Sci 17(3):337\u2013345","journal-title":"J Vet Sci"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-04984-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-04984-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-04984-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T14:46:43Z","timestamp":1757170003000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-04984-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,17]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["4984"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-04984-5","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,17]]},"assertion":[{"value":"22 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The ethic approval was reviewed and approved from The Yueyang Hospital of Traditional Chinese Medicine.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to participate"}},{"value":"All of the authors have consented to publish this research.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publish"}},{"value":"All authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}