{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:14:44Z","timestamp":1790252084062,"version":"4.1.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["109-2314-B-002-135- and 110-2314-B-002-085"],"award-info":[{"award-number":["109-2314-B-002-135- and 110-2314-B-002-085"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s12035-025-05016-y","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T03:53:04Z","timestamp":1746849184000},"page":"11986-12003","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lacosamide Is a Novel Drug That Improves AGTPBP1 Knockout-Mediated Impairment of Neuronal and Dopaminergic Function"],"prefix":"10.1007","volume":"62","author":[{"given":"Hsin-Pei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shekhar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-Chin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Jui","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Chi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyh-Jye","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hwa","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Tso","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"issue":"9","key":"5016_CR1","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.3390\/biomedicines9091157","volume":"9","author":"FC Baltan\u00e1s","year":"2021","unstructured":"Baltan\u00e1s FC, Berciano MT, Santos E, Lafarga M (2021) The Childhood-Onset Neurodegeneration with Cerebellar Atrophy (CONDCA) disease caused by AGTPBP1 gene mutations: the Purkinje cell degeneration mouse as an animal model for the study of this human disease. Biomedicines 9(9):1157","journal-title":"Biomedicines"},{"issue":"8","key":"5016_CR2","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1002\/ajmg.a.61198","volume":"179","author":"M Karakaya","year":"2019","unstructured":"Karakaya M, Paketci C, Altmueller J, Thiele H, Hoelker I, Yis U, Wirth B (2019) Biallelic variant in AGTPBP1 causes infantile lower motor neuron degeneration and cerebellar atrophy. Am J Med Genet A 179(8):1580\u20131584. https:\/\/doi.org\/10.1002\/ajmg.a.61198","journal-title":"Am J Med Genet A"},{"issue":"4","key":"5016_CR3","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.cell.2010.10.014","volume":"143","author":"K Rogowski","year":"2010","unstructured":"Rogowski K, van Dijk J, Magiera MM, Bosc C, Deloulme JC, Bosson A, Peris L, Gold ND et al (2010) A family of protein-deglutamylating enzymes associated with neurodegeneration. Cell 143(4):564\u2013578. https:\/\/doi.org\/10.1016\/j.cell.2010.10.014","journal-title":"Cell"},{"issue":"1","key":"5016_CR4","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1074\/mcp.M114.040360","volume":"14","author":"S Tanco","year":"2015","unstructured":"Tanco S, Tort O, Demol H, Aviles FX, Gevaert K, Van Damme P, Lorenzo J (2015) C-terminomics screen for natural substrates of cytosolic carboxypeptidase 1 reveals processing of acidic protein C termini. Mol Cell Proteomics 14(1):177\u2013190. https:\/\/doi.org\/10.1074\/mcp.M114.040360","journal-title":"Mol Cell Proteomics"},{"issue":"6","key":"5016_CR5","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1091\/mbc.4.6.615","volume":"4","author":"S Audebert","year":"1993","unstructured":"Audebert S, Desbruy\u00e8res E, Gruszczynski C, Koulakoff A, Gros F, Denoulet P, Edd\u00e9 B (1993) Reversible polyglutamylation of alpha- and beta-tubulin and microtubule dynamics in mouse brain neurons. Mol Biol Cell 4(6):615\u2013626. https:\/\/doi.org\/10.1091\/mbc.4.6.615","journal-title":"Mol Biol Cell"},{"issue":"16","key":"5016_CR6","doi-asserted-by":"publisher","first-page":"12839","DOI":"10.1074\/jbc.M011380200","volume":"276","author":"C Bonnet","year":"2001","unstructured":"Bonnet C, Boucher D, Lazereg S, Pedrotti B, Islam K, Denoulet P, Larcher JC (2001) Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation. J Biol Chem 276(16):12839\u201312848. https:\/\/doi.org\/10.1074\/jbc.M011380200","journal-title":"J Biol Chem"},{"key":"5016_CR7","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1073\/pnas.0611547104","volume":"104","author":"K Ikegami","year":"2007","unstructured":"Ikegami K, Heier R, Taruishi M, Takagi H, Shimma S, Taira S, Hatanaka K, Morone N et al (2007) Loss of -tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function. Proc Natl Acad Sci U S A 104:3213\u20133218. https:\/\/doi.org\/10.1073\/pnas.0611547104","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"5016_CR8","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1091\/mbc.e09-11-0967","volume":"21","author":"MC Stone","year":"2010","unstructured":"Stone MC, Nguyen MM, Tao J, Allender DL, Rolls MM (2010) Global up-regulation of microtubule dynamics and polarity reversal during regeneration of an axon from a dendrite. Mol Biol Cell 21(5):767\u2013777. https:\/\/doi.org\/10.1091\/mbc.e09-11-0967","journal-title":"Mol Biol Cell"},{"issue":"1","key":"5016_CR9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.neuron.2010.08.013","volume":"68","author":"J Li","year":"2010","unstructured":"Li J, Gu X, Ma Y, Calicchio ML, Kong D, Teng YD, Yu L, Crain AM et al (2010) Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-\u03baB signaling. Neuron 68(1):45\u201360. https:\/\/doi.org\/10.1016\/j.neuron.2010.08.013","journal-title":"Neuron"},{"issue":"1","key":"5016_CR10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/s0306-4522(01)00169-5","volume":"105","author":"TC Dickson","year":"2001","unstructured":"Dickson TC, Vickers JC (2001) The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer\u2019s disease. Neuroscience 105(1):99\u2013107. https:\/\/doi.org\/10.1016\/s0306-4522(01)00169-5","journal-title":"Neuroscience"},{"issue":"7","key":"5016_CR11","doi-asserted-by":"publisher","first-page":"e1811","DOI":"10.1038\/cddis.2015.169","volume":"6","author":"JC Koch","year":"2015","unstructured":"Koch JC, Bitow F, Haack J, d\u2019Hedouville Z, Zhang JN, T\u00f6nges L, Michel U, Oliveira LMA et al (2015) Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons. Cell Death Dis 6(7):e1811\u2013e1811. https:\/\/doi.org\/10.1038\/cddis.2015.169","journal-title":"Cell Death Dis"},{"issue":"1","key":"5016_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13229-016-0068-x","volume":"7","author":"AMH Young","year":"2016","unstructured":"Young AMH, Chakrabarti B, Roberts D, Lai M-C, Suckling J, Baron-Cohen S (2016) From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition. Molecular Autism 7(1):9. https:\/\/doi.org\/10.1186\/s13229-016-0068-x","journal-title":"Molecular Autism"},{"issue":"1","key":"5016_CR13","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1083\/jcb.201709028","volume":"218","author":"S Gilmore-Hall","year":"2019","unstructured":"Gilmore-Hall S, Kuo J, Ward JM, Zahra R, Morrison RS, Perkins G, La Spada AR (2019) CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice. J Cell Biol 218(1):206\u2013219. https:\/\/doi.org\/10.1083\/jcb.201709028","journal-title":"J Cell Biol"},{"issue":"6","key":"5016_CR14","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.neuron.2010.05.024","volume":"66","author":"L Chakrabarti","year":"2010","unstructured":"Chakrabarti L, Zahra R, Jackson SM, Kazemi-Esfarjani P, Sopher BL, Mason AG, Toneff T, Ryu S et al (2010) Mitochondrial dysfunction in NnaD mutant flies and Purkinje cell degeneration mice reveals a role for Nna proteins in neuronal bioenergetics. Neuron 66(6):835\u2013847. https:\/\/doi.org\/10.1016\/j.neuron.2010.05.024","journal-title":"Neuron"},{"issue":"22","key":"5016_CR15","doi-asserted-by":"publisher","first-page":"9973","DOI":"10.1128\/mcb.25.22.9973-9984.2005","volume":"25","author":"N Arimura","year":"2005","unstructured":"Arimura N, M\u00e9nager C, Kawano Y, Yoshimura T, Kawabata S, Hattori A, Fukata Y, Amano M et al (2005) Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol 25(22):9973\u20139984. https:\/\/doi.org\/10.1128\/mcb.25.22.9973-9984.2005","journal-title":"Mol Cell Biol"},{"issue":"5561","key":"5016_CR16","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1126\/science.1068912","volume":"295","author":"A Fernandez-Gonzalez","year":"2002","unstructured":"Fernandez-Gonzalez A, La Spada AR, Treadaway J, Higdon JC, Harris BS, Sidman RL, Morgan JI, Zuo J (2002) Purkinje cell degeneration (pcd) phenotypes caused by mutations in the axotomy-induced gene, Nna1. Science 295(5561):1904\u20131906. https:\/\/doi.org\/10.1126\/science.1068912","journal-title":"Science"},{"issue":"1","key":"5016_CR17","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.cell.2004.11.012","volume":"120","author":"T Yoshimura","year":"2005","unstructured":"Yoshimura T, Kawano Y, Arimura N, Kawabata S, Kikuchi A, Kaibuchi K (2005) GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell 120(1):137\u2013149. https:\/\/doi.org\/10.1016\/j.cell.2004.11.012","journal-title":"Cell"},{"issue":"8","key":"5016_CR18","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/90476","volume":"4","author":"N Inagaki","year":"2001","unstructured":"Inagaki N, Chihara K, Arimura N, M\u00e9nager C, Kawano Y, Matsuo N, Nishimura T, Amano M et al (2001) CRMP-2 induces axons in cultured hippocampal neurons. Nat Neurosci 4(8):781\u2013782. https:\/\/doi.org\/10.1038\/90476","journal-title":"Nat Neurosci"},{"issue":"3","key":"5016_CR19","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1093\/cercor\/bhab228","volume":"32","author":"Y Yamazaki","year":"2022","unstructured":"Yamazaki Y, Moizumi M, Nagai J, Hatashita Y, Cai T, Kolattukudy P, Inoue T, Goshima Y et al (2022) Requirement of CRMP2 phosphorylation in neuronal migration of developing mouse cerebral cortex and hippocampus and redundant roles of CRMP1 and CRMP4. Cereb Cortex 32(3):520\u2013527. https:\/\/doi.org\/10.1093\/cercor\/bhab228","journal-title":"Cereb Cortex"},{"issue":"8","key":"5016_CR20","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/ncb825","volume":"4","author":"Y Fukata","year":"2002","unstructured":"Fukata Y, Itoh TJ, Kimura T, M\u00e9nager C, Nishimura T, Shiromizu T, Watanabe H, Inagaki N et al (2002) CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. Nat Cell Biol 4(8):583\u2013591. https:\/\/doi.org\/10.1038\/ncb825","journal-title":"Nat Cell Biol"},{"issue":"4","key":"5016_CR21","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1523\/jneurosci.5563-11.2012","volume":"32","author":"N Yamashita","year":"2012","unstructured":"Yamashita N, Ohshima T, Nakamura F, Kolattukudy P, Honnorat J, Mikoshiba K, Goshima Y (2012) Phosphorylation of CRMP2 (collapsin response mediator protein 2) is involved in proper dendritic field organization. J Neurosci 32(4):1360\u20131365. https:\/\/doi.org\/10.1523\/jneurosci.5563-11.2012","journal-title":"J Neurosci"},{"issue":"2","key":"5016_CR22","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s12035-014-8775-9","volume":"51","author":"SM Wilson","year":"2015","unstructured":"Wilson SM, Khanna R (2015) Specific binding of lacosamide to collapsin response mediator protein 2 (CRMP2) and direct impairment of its canonical function: implications for the therapeutic potential of lacosamide. Mol Neurobiol 51(2):599\u2013609. https:\/\/doi.org\/10.1007\/s12035-014-8775-9","journal-title":"Mol Neurobiol"},{"issue":"12","key":"5016_CR23","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/nrd2764","volume":"7","author":"E Perucca","year":"2008","unstructured":"Perucca E, Yasothan U, Clincke G, Kirkpatrick P (2008) Lacosamide. Nat Rev Drug Discovery 7(12):973\u2013974. https:\/\/doi.org\/10.1038\/nrd2764","journal-title":"Nat Rev Drug Discovery"},{"key":"5016_CR24","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.neuroscience.2012.02.038","volume":"210","author":"SM Wilson","year":"2012","unstructured":"Wilson SM, Xiong W, Wang Y, Ping X, Head JD, Brittain JM, Gagare PD, Ramachandran PV et al (2012) Prevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization. Neuroscience 210:451\u2013466. https:\/\/doi.org\/10.1016\/j.neuroscience.2012.02.038","journal-title":"Neuroscience"},{"issue":"4","key":"5016_CR25","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1002\/epi4.12269","volume":"3","author":"A Granit","year":"2018","unstructured":"Granit A, Tetro N, Shmuel M, Peretz T, Eyal S (2018) Lacosamide at therapeutic concentrations induces histone hyperacetylation in vitro. Epilepsia Open 3(4):535\u2013539. https:\/\/doi.org\/10.1002\/epi4.12269","journal-title":"Epilepsia Open"},{"key":"5016_CR26","doi-asserted-by":"publisher","unstructured":"Lazzarotto L, Pfl\u00fcger P, Regner GG, Santos FM, Aguirre DG, Brito VB, Moura DJ, dos Santos NM et al (2021) Lacosamide improves biochemical, genotoxic, and mitochondrial parameters after PTZ-kindling model in mice. 35(2):351\u2013363. https:\/\/doi.org\/10.1111\/fcp.12598","DOI":"10.1111\/fcp.12598"},{"key":"5016_CR27","doi-asserted-by":"publisher","unstructured":"Chen SH, Chow JM, Hsieh YY, Lin CY, Hsu KW, Hsieh WS, Chi W-M, Shabangu BM et al (2019) HDAC1,2 knock-out and HDACi induced cell apoptosis in imatinib-resistant K562 cells. Int J Mol Sci 20(9). https:\/\/doi.org\/10.3390\/ijms20092271","DOI":"10.3390\/ijms20092271"},{"key":"5016_CR28","doi-asserted-by":"publisher","unstructured":"Chen SH, Hsieh YY, Tzeng HE, Lin CY, Hsu KW, Chiang YS, Lin S-M, Su M-J et al (2020) ABL genomic editing sufficiently abolishes oncogenesis of human chronic myeloid leukemia cells in vitro and in vivo. Cancers (Basel) 12(6). https:\/\/doi.org\/10.3390\/cancers12061399","DOI":"10.3390\/cancers12061399"},{"key":"5016_CR29","doi-asserted-by":"publisher","first-page":"726478","DOI":"10.1155\/2013\/726478","volume":"2013","author":"SH Lee","year":"2013","unstructured":"Lee SH, Kang JW, Lin T, Lee JE, Jin DI (2013) Teratogenic potential of antiepileptic drugs in the zebrafish model. Biomed Res Int 2013:726478. https:\/\/doi.org\/10.1155\/2013\/726478","journal-title":"Biomed Res Int"},{"key":"5016_CR30","doi-asserted-by":"publisher","unstructured":"Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF (1995) Stages of embryonic development of the zebrafish. 203(3):253\u2013310. https:\/\/doi.org\/10.1002\/aja.1002030302","DOI":"10.1002\/aja.1002030302"},{"issue":"42","key":"5016_CR31","doi-asserted-by":"publisher","first-page":"30454","DOI":"10.1074\/jbc.M113.497933","volume":"288","author":"PJ Lyons","year":"2013","unstructured":"Lyons PJ, Sapio MR, Fricker LD (2013) Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development. J Biol Chem 288(42):30454\u201330462. https:\/\/doi.org\/10.1074\/jbc.M113.497933","journal-title":"J Biol Chem"},{"key":"5016_CR32","doi-asserted-by":"publisher","unstructured":"Landis SC, Mullen RJ (1978) The development and degeneration of Purkinje cells in pcd mutant mice. 177(1):125\u2013143. https:\/\/doi.org\/10.1002\/cne.901770109","DOI":"10.1002\/cne.901770109"},{"issue":"5","key":"5016_CR33","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/s41388-023-02907-z","volume":"43","author":"FR Palma","year":"2024","unstructured":"Palma FR, Gantner BN, Sakiyama MJ, Kayzuka C, Shukla S, Lacchini R, Cunniff B, Bonini MG (2024) ROS production by mitochondria: function or dysfunction? Oncogene 43(5):295\u2013303. https:\/\/doi.org\/10.1038\/s41388-023-02907-z","journal-title":"Oncogene"},{"key":"5016_CR34","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","volume":"552","author":"LD Zorova","year":"2018","unstructured":"Zorova LD, Popkov VA, Plotnikov EY, Silachev DN, Pevzner IB, Jankauskas SS, Babenko VA, Zorov SD et al (2018) Mitochondrial membrane potential. Anal Biochem 552:50\u201359. https:\/\/doi.org\/10.1016\/j.ab.2017.07.009","journal-title":"Anal Biochem"},{"issue":"3","key":"5016_CR35","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.neuroscience.2007.08.017","volume":"149","author":"RA Bergstrom","year":"2007","unstructured":"Bergstrom RA, Sinjoanu RC, Ferreira A (2007) Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons. Neuroscience 149(3):527\u2013536. https:\/\/doi.org\/10.1016\/j.neuroscience.2007.08.017","journal-title":"Neuroscience"},{"key":"5016_CR36","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3389\/fncel.2017.00359","volume":"11","author":"J Gilbert","year":"2017","unstructured":"Gilbert J, Man HY (2017) Fundamental elements in autism: from neurogenesis and neurite growth to synaptic plasticity. Front Cell Neurosci 11:359. https:\/\/doi.org\/10.3389\/fncel.2017.00359","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"5016_CR37","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1002\/jnr.22190","volume":"88","author":"M Hocquemiller","year":"2010","unstructured":"Hocquemiller M, Vitry S, Bigou S, Bruy\u00e8re J, Ausseil J, Heard JM (2010) GAP43 overexpression and enhanced neurite outgrowth in mucopolysaccharidosis type IIIB cortical neuron cultures. J Neurosci Res 88(1):202\u2013213. https:\/\/doi.org\/10.1002\/jnr.22190","journal-title":"J Neurosci Res"},{"issue":"6","key":"5016_CR38","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1111\/jnc.15225","volume":"157","author":"F Nie","year":"2021","unstructured":"Nie F, Zhang Q, Ma J, Wang P, Gu R, Han J, Zhang R (2021) Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro. J Neurochem 157(6):1745\u20131758. https:\/\/doi.org\/10.1111\/jnc.15225","journal-title":"J Neurochem"},{"issue":"4","key":"5016_CR39","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.14336\/ad.2023.0902","volume":"15","author":"Y Yao","year":"2024","unstructured":"Yao Y, Jin C, Liao Y, Huang X, Wei Z, Zhang Y, Li D, Su H et al (2024) Schizophrenia-like behaviors arising from dysregulated proline metabolism are associated with altered neuronal morphology and function in mice with hippocampal PRODH deficiency. Aging Dis 15(4):1952\u20131968. https:\/\/doi.org\/10.14336\/ad.2023.0902","journal-title":"Aging Dis"},{"issue":"9\u201310","key":"5016_CR40","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1002\/prca.201500004","volume":"9","author":"D Martins-de-Souza","year":"2015","unstructured":"Martins-de-Souza D, Cassoli JS, Nascimento JM, Hensley K, Guest PC, Pinzon-Velasco AM, Turck CW (2015) The protein interactome of collapsin response mediator protein-2 (CRMP2\/DPYSL2) reveals novel partner proteins in brain tissue. 9(9\u201310):817\u2013831. https:\/\/doi.org\/10.1002\/prca.201500004","journal-title":"Proteomics Clin Appl"},{"key":"5016_CR41","doi-asserted-by":"publisher","unstructured":"Nomoto M, Konopaske GT, Yamashita N, Aoki R, Jitsuki-Takahashi A, Nakamura H, Makihara H, Saito M et al (2021) Clinical evidence that a dysregulated master neural network modulator may aid in diagnosing schizophrenia. 118(31):e2100032118. https:\/\/doi.org\/10.1073\/pnas.2100032118","DOI":"10.1073\/pnas.2100032118"},{"issue":"48","key":"5016_CR42","doi-asserted-by":"publisher","first-page":"50176","DOI":"10.1074\/jbc.C400412200","volume":"279","author":"AR Cole","year":"2004","unstructured":"Cole AR, Knebel A, Morrice NA, Robertson LA, Irving AJ, Connolly CN, Sutherland C (2004) GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons. J Biol Chem 279(48):50176\u201350180","journal-title":"J Biol Chem"},{"key":"5016_CR43","doi-asserted-by":"publisher","first-page":"113253","DOI":"10.1016\/j.expneurol.2020.113253","volume":"328","author":"Y-Y Sun","year":"2020","unstructured":"Sun Y-Y, Zhu L, Sun Z-L, Feng D-F (2020) CRMP2 improves memory deficits by enhancing the maturation of neuronal dendritic spines after traumatic brain injury. Exp Neurol 328:113253. https:\/\/doi.org\/10.1016\/j.expneurol.2020.113253","journal-title":"Exp Neurol"},{"key":"5016_CR44","doi-asserted-by":"publisher","unstructured":"Wang X, Yu Y, Ma R, Shao N, Meng H (2018) Lacosamide modulates collapsin response mediator protein 2 and inhibits mossy fiber sprouting after kainic acid-induced status epilepticus. 29(16):1384\u20131390. https:\/\/doi.org\/10.1097\/wnr.0000000000001123","DOI":"10.1097\/wnr.0000000000001123"},{"key":"5016_CR45","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3389\/fncel.2014.00196","volume":"8","author":"SM Wilson","year":"2014","unstructured":"Wilson SM, Moutal A, Melemedjian OK, Wang Y, Ju W, Fran\u00e7ois-Moutal L, Khanna M, Khanna R (2014) The functionalized amino acid (S)-lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth. Front Cell Neurosci 8:196. https:\/\/doi.org\/10.3389\/fncel.2014.00196","journal-title":"Front Cell Neurosci"},{"issue":"11","key":"5016_CR46","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.15252\/embj.201695810","volume":"36","author":"S Camandola","year":"2017","unstructured":"Camandola S, Mattson MP (2017) Brain metabolism in health, aging, and neurodegeneration. Embo J 36(11):1474\u20131492. https:\/\/doi.org\/10.15252\/embj.201695810","journal-title":"Embo J"},{"issue":"2","key":"5016_CR47","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/nep3.46","volume":"2","author":"JY Magdaleno Roman","year":"2024","unstructured":"Magdaleno Roman JY, Chapa Gonz\u00e1lez C (2024) Glutamate and excitotoxicity in central nervous system disorders: ionotropic glutamate receptors as a target for neuroprotection. 2(2):137\u2013150. https:\/\/doi.org\/10.1002\/nep3.46","journal-title":"Neuroprotection"},{"issue":"1","key":"5016_CR48","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41467-017-02729-0","volume":"9","author":"BT Selvaraj","year":"2018","unstructured":"Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB et al (2018) C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity. Nat Commun 9(1):347. https:\/\/doi.org\/10.1038\/s41467-017-02729-0","journal-title":"Nat Commun"},{"key":"5016_CR49","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fncel.2015.00091","volume":"9","author":"AA Kritis","year":"2015","unstructured":"Kritis AA, Stamoula EG, Paniskaki KA, Vavilis TD (2015) Researching glutamate - induced cytotoxicity in different cell lines: a comparative\/collective analysis\/study. Front Cell Neurosci 9:91. https:\/\/doi.org\/10.3389\/fncel.2015.00091","journal-title":"Front Cell Neurosci"},{"key":"5016_CR50","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3389\/fpsyt.2014.00047","volume":"5","author":"R Brisch","year":"2014","unstructured":"Brisch R, Saniotis A, Wolf R, Bielau H, Bernstein HG, Steiner J, Bogerts B, Braun K et al (2014) The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue. Front Psychiatry 5:47. https:\/\/doi.org\/10.3389\/fpsyt.2014.00047","journal-title":"Front Psychiatry"},{"issue":"1","key":"5016_CR51","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.neuroscience.2004.01.020","volume":"125","author":"F Delis","year":"2004","unstructured":"Delis F, Mitsacos A, Giompres P (2004) Dopamine receptor and transporter levels are altered in the brain of Purkinje cell degeneration mutant mice. Neuroscience 125(1):255\u2013268. https:\/\/doi.org\/10.1016\/j.neuroscience.2004.01.020","journal-title":"Neuroscience"},{"issue":"12","key":"5016_CR52","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1038\/nrn983","volume":"3","author":"J Lotharius","year":"2002","unstructured":"Lotharius J, Brundin P (2002) Pathogenesis of Parkinson\u2019s disease: dopamine, vesicles and \u03b1-synuclein. Nat Rev Neurosci 3(12):932\u2013942. https:\/\/doi.org\/10.1038\/nrn983","journal-title":"Nat Rev Neurosci"},{"key":"5016_CR53","doi-asserted-by":"publisher","unstructured":"Schmack K, Bosc M, Ott T, Sturgill JF, Kepecs A (2021) Striatal dopamine mediates hallucination-like perception in mice. Science 372(6537). https:\/\/doi.org\/10.1126\/science.abf4740","DOI":"10.1126\/science.abf4740"},{"issue":"11","key":"5016_CR54","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1001\/archneur.64.11.1575","volume":"64","author":"ND Volkow","year":"2007","unstructured":"Volkow ND, Fowler JS, Wang G-J, Swanson JM, Telang F (2007) Dopamine in drug abuse and addiction: results of imaging studies and treatment implications. Arch Neurol 64(11):1575\u20131579. https:\/\/doi.org\/10.1001\/archneur.64.11.1575. (%J Archives of Neurology)","journal-title":"Arch Neurol"},{"key":"5016_CR55","doi-asserted-by":"publisher","unstructured":"Quelle-Regaldie A, Sobrido-Came\u00e1n D, Barreiro-Iglesias A, Sobrido MJ, S\u00e1nchez L (2021) Zebrafish models of autosomal recessive ataxias. Cells 10(4). https:\/\/doi.org\/10.3390\/cells10040836","DOI":"10.3390\/cells10040836"},{"key":"5016_CR56","doi-asserted-by":"publisher","unstructured":"Quelle-Regaldie A, Sobrido-Came\u00e1n D, Barreiro-Iglesias A, Sobrido MJ, S\u00e1nchez L (2021) Zebrafish models of autosomal dominant ataxias. Cells 10(2). https:\/\/doi.org\/10.3390\/cells10020421","DOI":"10.3390\/cells10020421"},{"issue":"1","key":"5016_CR57","doi-asserted-by":"publisher","first-page":"3072","DOI":"10.1038\/s41598-018-21470-2","volume":"8","author":"R Mu\u00f1oz-Casta\u00f1eda","year":"2018","unstructured":"Mu\u00f1oz-Casta\u00f1eda R, D\u00edaz D, Peris L, Andrieux A, Bosc C, Mu\u00f1oz-Casta\u00f1eda JM, Janke C, Alonso JR et al (2018) Cytoskeleton stability is essential for the integrity of the cerebellum and its motor- and affective-related behaviors. Sci Rep 8(1):3072. https:\/\/doi.org\/10.1038\/s41598-018-21470-2","journal-title":"Sci Rep"},{"issue":"6106","key":"5016_CR58","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1038\/325711a0","volume":"325","author":"L Havton","year":"1987","unstructured":"Havton L, Kellerth JO (1987) Regeneration by supernumerary axons with synaptic terminals in spinal motoneurons of cats. Nature 325(6106):711\u2013714. https:\/\/doi.org\/10.1038\/325711a0","journal-title":"Nature"},{"issue":"4","key":"5016_CR59","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/sj.mp.4002120","volume":"13","author":"AM Lepagnol-Bestel","year":"2008","unstructured":"Lepagnol-Bestel AM, Maussion G, Boda B, Cardona A, Iwayama Y, Delezoide AL, Moalic J-M, Muller D et al (2008) SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects. Mol Psychiatry 13(4):385\u2013397. https:\/\/doi.org\/10.1038\/sj.mp.4002120","journal-title":"Mol Psychiatry"},{"issue":"8","key":"5016_CR60","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1097\/wnr.0000000000001791","volume":"33","author":"K Rumpansuwon","year":"2022","unstructured":"Rumpansuwon K, Prommahom A, Dharmasaroja P (2022) eEF1A2 knockdown impairs neuronal proliferation and inhibits neurite outgrowth of differentiating neurons. NeuroReport 33(8):336\u2013344. https:\/\/doi.org\/10.1097\/wnr.0000000000001791","journal-title":"NeuroReport"},{"issue":"18","key":"5016_CR61","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1097\/wnr.0000000000000063","volume":"24","author":"S Seiler","year":"2013","unstructured":"Seiler S, Pollini D, Di Santo S, Widmer HR (2013) Antagonizing Nogo-receptor 1 promotes the number of cultured dopaminergic neurons and elongates their neurites. NeuroReport 24(18):1047\u20131052. https:\/\/doi.org\/10.1097\/wnr.0000000000000063","journal-title":"NeuroReport"},{"issue":"9","key":"5016_CR62","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1002\/ejp.1246","volume":"22","author":"Y Wang","year":"2018","unstructured":"Wang Y, Huo F (2018) Inhibition of sympathetic sprouting in CCD rats by lacosamide. Eur J Pain 22(9):1641\u20131650. https:\/\/doi.org\/10.1002\/ejp.1246","journal-title":"Eur J Pain"},{"issue":"23","key":"5016_CR63","doi-asserted-by":"publisher","first-page":"4606","DOI":"10.1016\/j.cub.2020.09.002","volume":"30","author":"JP Barrios","year":"2020","unstructured":"Barrios JP, Wang W-C, England R, Reifenberg E, Douglass AD (2020) Hypothalamic dopamine neurons control sensorimotor behavior by modulating brainstem premotor nuclei in zebrafish. Curr Biol 30(23):4606-4618.e4604. https:\/\/doi.org\/10.1016\/j.cub.2020.09.002","journal-title":"Curr Biol"},{"key":"5016_CR64","doi-asserted-by":"publisher","first-page":"105423","DOI":"10.1016\/j.phrs.2021.105423","volume":"165","author":"HI Kim","year":"2021","unstructured":"Kim HI, Lee S, Lim J, Chung S, Koo TS, Ji YG, Suh Y-G, Son WS et al (2021) ERR\u03b3 ligand HPB2 upregulates BDNF-TrkB and enhances dopaminergic neuronal phenotype. Pharmacol Res 165:105423. https:\/\/doi.org\/10.1016\/j.phrs.2021.105423","journal-title":"Pharmacol Res"},{"issue":"12","key":"5016_CR65","doi-asserted-by":"publisher","first-page":"101797","DOI":"10.1016\/j.isci.2020.101797","volume":"23","author":"C Bus","year":"2020","unstructured":"Bus C, Zizmare L, Feldkaemper M, Geisler S, Zarani M, Schaedler A, Klose F, Admard J et al (2020) Human dopaminergic neurons lacking PINK1 exhibit disrupted dopamine metabolism related to vitamin B6 co-factors. iScience 23(12):101797. https:\/\/doi.org\/10.1016\/j.isci.2020.101797","journal-title":"iScience"},{"issue":"8","key":"5016_CR66","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00018-023-04879-5","volume":"80","author":"S Pose-M\u00e9ndez","year":"2023","unstructured":"Pose-M\u00e9ndez S, Schramm P, Valishetti K, K\u00f6ster RW (2023) Development, circuitry, and function of the zebrafish cerebellum. Cell Mol Life Sci 80(8):227. https:\/\/doi.org\/10.1007\/s00018-023-04879-5","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"5016_CR67","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1073\/pnas.73.1.208","volume":"73","author":"RJ Mullen","year":"1976","unstructured":"Mullen RJ, Eicher EM, Sidman RL (1976) Purkinje cell degeneration, a new neurological mutation in the mouse. Proc Natl Acad Sci U S A 73(1):208\u2013212. https:\/\/doi.org\/10.1073\/pnas.73.1.208","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5016_CR68","doi-asserted-by":"publisher","first-page":"e07892","DOI":"10.7554\/eLife.07892","volume":"4","author":"AS Machado","year":"2015","unstructured":"Machado AS, Darmohray DM, Fayad J, Marques HG, Carey MR (2015) A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice. Elife 4:e07892. https:\/\/doi.org\/10.7554\/eLife.07892","journal-title":"Elife"},{"key":"5016_CR69","doi-asserted-by":"publisher","unstructured":"Sarasamma S, Karim A, Orengo JP (2023) Zebrafish models of rare neurological diseases like spinocerebellar ataxias (SCAs): advantages and limitations. Biology 12(10). https:\/\/doi.org\/10.3390\/biology12101322","DOI":"10.3390\/biology12101322"},{"key":"5016_CR70","doi-asserted-by":"publisher","unstructured":"Vaz RL, Outeiro TF, Ferreira JJ (2018) Zebrafish as an animal model for drug discovery in Parkinson\u2019s disease and other movement disorders: a systematic review. 9. https:\/\/doi.org\/10.3389\/fneur.2018.00347","DOI":"10.3389\/fneur.2018.00347"},{"issue":"6","key":"5016_CR71","doi-asserted-by":"publisher","first-page":"e0157405","DOI":"10.1371\/journal.pone.0157405","volume":"11","author":"AK Pollard","year":"2016","unstructured":"Pollard AK, Craig EL, Chakrabarti L (2016) Mitochondrial complex 1 activity measured by spectrophotometry is reduced across all brain regions in ageing and more specifically in neurodegeneration. PLoS ONE 11(6):e0157405. https:\/\/doi.org\/10.1371\/journal.pone.0157405","journal-title":"PLoS ONE"}],"updated-by":[{"DOI":"10.1007\/s12035-025-05572-3","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000}}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05016-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-05016-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05016-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T05:02:38Z","timestamp":1764392558000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-05016-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,10]]},"references-count":71,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["5016"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-05016-y","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,10]]},"assertion":[{"value":"2 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: the listed MO (tMO: GTCTCGATATGCTGCCAAGGTCATG) for zebrafish experiment should be listed as (sMO: 5\u2019-GGTGTTCTGTACGAAAACATCAAGT-3\u2019).","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2025","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s12035-025-05572-3","URL":"https:\/\/doi.org\/10.1007\/s12035-025-05572-3","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal ethical committee of National Taiwan University approved the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"All the authors consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}