{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:57:02Z","timestamp":1786982222141,"version":"build-2736575974"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Natural Science Foundation of Ningbo","award":["(2023J136)"],"award-info":[{"award-number":["(2023J136)"]}]},{"name":"key disciplines of Ningbo City","award":["zd2020008"],"award-info":[{"award-number":["zd2020008"]}]},{"name":"key disciplines of Ningbo City","award":["2022-B15-A"],"award-info":[{"award-number":["2022-B15-A"]}]},{"name":"the science and technology plan of major research projects of Xiamen high quality development","award":["2024GZL-ZD09"],"award-info":[{"award-number":["2024GZL-ZD09"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s12035-025-05072-4","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T17:43:27Z","timestamp":1748367807000},"page":"12574-12587","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Trifluoperazine improves postoperative cognition by influencing astrocyte endfoot morphology and aquaporin-4 polarity"],"prefix":"10.1007","volume":"62","author":[{"given":"Chunqu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angyang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"issue":"9","key":"5072_CR1","doi-asserted-by":"publisher","first-page":"e01750","DOI":"10.1002\/brb3.1750","volume":"10","author":"K Relander","year":"2020","unstructured":"Relander K, Hietanen M, Rantanen K, R\u00e4m\u00f6 J, Vento A, Saastamoinen KP, Roine RO, Soinne L (2020) Postoperative cognitive change after cardiac surgery predicts long-term cognitive outcome. Brain and behavior 10(9):e01750. https:\/\/doi.org\/10.1002\/brb3.1750","journal-title":"Brain and behavior"},{"key":"5072_CR2","doi-asserted-by":"publisher","unstructured":"Mahanna-Gabrielli E, Schenning KJ, Eriksson LI, Browndyke JN, Wright CB, Culley DJ, Evered L, Scott DA, Wang NY, Brown CHt, Oh E, Purdon P, Inouye S, Berger M, Whittington RA, Price CC, Deiner S (2019) State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018. British J Anaesthesia 123(4):464-478. https:\/\/doi.org\/10.1016\/j.bja.2019.07.004","DOI":"10.1016\/j.bja.2019.07.004"},{"issue":"7","key":"5072_CR3","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.jalz.2016.03.005","volume":"12","author":"SK Inouye","year":"2016","unstructured":"Inouye SK, Marcantonio ER, Kosar CM, Tommet D, Schmitt EM, Travison TG, Saczynski JS, Ngo LH, Alsop DC, Jones RN (2016) The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients. Alzheimer\u2019s Dementia 12(7):766\u2013775. https:\/\/doi.org\/10.1016\/j.jalz.2016.03.005","journal-title":"Alzheimer's Dementia"},{"key":"5072_CR4","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.ebiom.2018.10.021","volume":"37","author":"A Alam","year":"2018","unstructured":"Alam A, Hana Z, Jin Z, Suen KC, Ma D (2018) Surgery, neuroinflammation and cognitive impairment. EBioMedicine 37:547\u2013556. https:\/\/doi.org\/10.1016\/j.ebiom.2018.10.021","journal-title":"EBioMedicine"},{"key":"5072_CR5","doi-asserted-by":"publisher","first-page":"784154","DOI":"10.3389\/fncel.2021.784154","volume":"15","author":"X Liu","year":"2021","unstructured":"Liu X, Wu G, Tang N, Li L, Liu C, Wang F, Ke S (2021) Glymphatic Drainage Blocking Aggravates Brain Edema, Neuroinflammation via Modulating TNF-\u03b1, IL-10, and AQP4 After Intracerebral Hemorrhage in Rats. Front Cell Neurosci 15:784154. https:\/\/doi.org\/10.3389\/fncel.2021.784154","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"5072_CR6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1152\/physrev.00050.2017","volume":"99","author":"MD Sweeney","year":"2019","unstructured":"Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV (2019) Blood-Brain Barrier: From Physiology to Disease and Back. Physiol Rev 99(1):21\u201378. https:\/\/doi.org\/10.1152\/physrev.00050.2017","journal-title":"Physiol Rev"},{"key":"5072_CR7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-091922-031205","author":"B D\u00edaz-Castro","year":"2023","unstructured":"D\u00edaz-Castro B, Robel S, Mishra A (2023) Astrocyte Endfeet in Brain Function and Pathology: Open Questions. Annu Rev Neurosci. https:\/\/doi.org\/10.1146\/annurev-neuro-091922-031205","journal-title":"Annu Rev Neurosci"},{"key":"5072_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnagi.2019.00001","volume":"11","author":"R Aldea","year":"2019","unstructured":"Aldea R, Weller RO, Wilcock DM, Carare RO, Richardson G (2019) Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain. Front Aging Neurosci 11:1. https:\/\/doi.org\/10.3389\/fnagi.2019.00001","journal-title":"Front Aging Neurosci"},{"issue":"5","key":"5072_CR9","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1002\/glia.23304","volume":"66","author":"R Eilam","year":"2018","unstructured":"Eilam R, Segal M, Malach R, Sela M, Arnon R, Aharoni R (2018) Astrocyte disruption of neurovascular communication is linked to cortical damage in an animal model of multiple sclerosis. Glia 66(5):1098\u20131117. https:\/\/doi.org\/10.1002\/glia.23304","journal-title":"Glia"},{"key":"5072_CR10","doi-asserted-by":"publisher","unstructured":"Zhu B, Zhou Y, Zhou W, Chen C, Wang J, Xu S, Wang Q (2022) Electroacupuncture modulates gut microbiota in mice: A potential target in postoperative cognitive dysfunction. Anatomical record (Hoboken, NJ : 2007). https:\/\/doi.org\/10.1002\/ar.25065","DOI":"10.1002\/ar.25065"},{"key":"5072_CR11","doi-asserted-by":"publisher","first-page":"111215","DOI":"10.1016\/j.intimp.2023.111215","volume":"126","author":"B Zhu","year":"2023","unstructured":"Zhu B, Cao A, Chen C, Zhou W, Luo W, Gui Y, Wang Q, Xu Z, Wang J (2023) MMP-9 inhibition alleviates postoperative cognitive dysfunction by improving glymphatic function via regulating AQP4 polarity. Int Immunopharmacol 126:111215. https:\/\/doi.org\/10.1016\/j.intimp.2023.111215","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"5072_CR12","doi-asserted-by":"publisher","first-page":"61","DOI":"10.14336\/ad.2021.0731","volume":"13","author":"Y Wang","year":"2022","unstructured":"Wang Y, Huang C, Guo Q, Chu H (2022) Aquaporin-4 and Cognitive Disorders. Aging Dis 13(1):61\u201372. https:\/\/doi.org\/10.14336\/ad.2021.0731","journal-title":"Aging Dis"},{"issue":"6512","key":"5072_CR13","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1126\/science.abb8739","volume":"370","author":"M Nedergaard","year":"2020","unstructured":"Nedergaard M, Goldman SA (2020) Glymphatic failure as a final common pathway to dementia. Science (New York, NY) 370(6512):50\u201356. https:\/\/doi.org\/10.1126\/science.abb8739","journal-title":"Science (New York, NY)"},{"key":"5072_CR14","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3389\/fncel.2016.00105","volume":"10","author":"Z Li","year":"2016","unstructured":"Li Z, Mo N, Li L, Cao Y, Wang W, Liang Y, Deng H, Xing R, Yang L, Ni C, Chui D, Guo X (2016) Surgery-Induced Hippocampal Angiotensin II Elevation Causes Blood-Brain Barrier Disruption via MMP\/TIMP in Aged Rats. Front Cell Neurosci 10:105. https:\/\/doi.org\/10.3389\/fncel.2016.00105","journal-title":"Front Cell Neurosci"},{"key":"5072_CR15","doi-asserted-by":"publisher","first-page":"748637","DOI":"10.3389\/fnagi.2021.748637","volume":"13","author":"A Luo","year":"2021","unstructured":"Luo A, Li S, Wang X, Xie Z, Li S, Hua D (2021) Cefazolin Improves Anesthesia and Surgery-Induced Cognitive Impairments by Modulating Blood-Brain Barrier Function, Gut Bacteria and Short Chain Fatty Acids. Frontiers in aging neuroscience 13:748637. https:\/\/doi.org\/10.3389\/fnagi.2021.748637","journal-title":"Frontiers in aging neuroscience"},{"key":"5072_CR16","doi-asserted-by":"publisher","first-page":"183573","DOI":"10.1016\/j.bbamem.2021.183573","volume":"5","author":"NJ Sylvain","year":"1863","unstructured":"Sylvain NJ, Salman MM, Pushie MJ, Hou H, Meher V, Herlo R, Peeling L (1863) Kelly ME (2021) The effects of trifluoperazine on brain edema, aquaporin-4 expression and metabolic markers during the acute phase of stroke using photothrombotic mouse model. Biochim Biophys Acta 5:183573. https:\/\/doi.org\/10.1016\/j.bbamem.2021.183573","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"5072_CR17","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.cell.2020.03.037","volume":"181","author":"P Kitchen","year":"2020","unstructured":"Kitchen P, Salman MM, Halsey AM, Clarke-Bland C, MacDonald JA, Ishida H, Vogel HJ, Almutiri S, Logan A, Kreida S, Al-Jubair T, Winkel Missel J, Gourdon P, T\u00f6rnroth-Horsefield S, Conner MT, Ahmed Z, Conner AC, Bill RM (2020) Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema. Cell 181(4):784-799.e719. https:\/\/doi.org\/10.1016\/j.cell.2020.03.037","journal-title":"Cell"},{"key":"5072_CR18","doi-asserted-by":"publisher","first-page":"752771","DOI":"10.3389\/fncel.2021.752771","volume":"15","author":"HT Huang","year":"2021","unstructured":"Huang HT, Chen PC, Chen PS, Chiu WT, Kuo YM, Tzeng SF (2021) Inhibitory Effects of Trifluoperazine on Peripheral Proinflammatory Cytokine Expression and Hypothalamic Microglia Activation in Obese Mice Induced by Chronic Feeding With High-Fat-Diet. Front Cell Neurosci 15:752771. https:\/\/doi.org\/10.3389\/fncel.2021.752771","journal-title":"Front Cell Neurosci"},{"key":"5072_CR19","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/978-1-4939-8994-2_10","volume":"1916","author":"AK Kraeuter","year":"2019","unstructured":"Kraeuter AK, Guest PC, Sarnyai Z (2019) The Y-Maze for Assessment of Spatial Working and Reference Memory in Mice. Methods Mol Biol (Clifton, NJ) 1916:105\u2013111. https:\/\/doi.org\/10.1007\/978-1-4939-8994-2_10","journal-title":"Methods Mol Biol (Clifton, NJ)"},{"issue":"5","key":"5072_CR20","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.neubiorev.2004.06.006","volume":"28","author":"RN Hughes","year":"2004","unstructured":"Hughes RN (2004) The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory. Neurosci Biobehav Rev 28(5):497\u2013505. https:\/\/doi.org\/10.1016\/j.neubiorev.2004.06.006","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"5072_CR21","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s11011-019-00532-y","volume":"35","author":"Y Zhou","year":"2020","unstructured":"Zhou Y, Wu X, Ye L, Bai Y, Zhang H, Xuan Z, Feng Y, Zhang P, Chen Y, Yan Y, Zhu B, Cui W (2020) Edaravone at high concentrations attenuates cognitive dysfunctions induced by abdominal surgery under general anesthesia in aged mice. Metab Brain Dis 35(2):373\u2013383. https:\/\/doi.org\/10.1007\/s11011-019-00532-y","journal-title":"Metab Brain Dis"},{"issue":"5","key":"5072_CR22","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.14336\/ad.2020.0106","volume":"11","author":"D Han","year":"2020","unstructured":"Han D, Li Z, Liu T, Yang N, Li Y, He J, Qian M, Kuang Z, Zhang W, Ni C, Guo X (2020) Prebiotics Regulation of Intestinal Microbiota Attenuates Cognitive Dysfunction Induced by Surgery Stimulation in APP\/PS1 Mice. Aging Dis 11(5):1029\u20131045. https:\/\/doi.org\/10.14336\/ad.2020.0106","journal-title":"Aging Dis"},{"key":"5072_CR23","doi-asserted-by":"publisher","first-page":"380","DOI":"10.3389\/fncel.2018.00380","volume":"12","author":"Z Hoyk","year":"2018","unstructured":"Hoyk Z, T\u00f3th ME, L\u00e9n\u00e1rt N, Nagy D, Dukay B, Csefov\u00e1 A, Zvara \u00c1, Sepr\u00e9nyi G, Kincses A, Walter FR, Veszelka S, V\u00edgh J, Barab\u00e1si B, Harazin A, Kittel \u00c1, Pusk\u00e1s LG, Penke B, V\u00edgh L, Deli MA, S\u00e1ntha M (2018) Cerebrovascular Pathology in Hypertriglyceridemic APOB-100 Transgenic Mice. Front Cell Neurosci 12:380. https:\/\/doi.org\/10.3389\/fncel.2018.00380","journal-title":"Front Cell Neurosci"},{"issue":"6","key":"5072_CR24","doi-asserted-by":"publisher","first-page":"797","DOI":"10.7150\/ijms.82677","volume":"20","author":"R Xing","year":"2023","unstructured":"Xing R, Cheng J, Yu J, Li S, Ma H, Zhao Y (2023) Trifluoperazine reduces apoptosis and inflammatory responses in traumatic brain injury by preventing the accumulation of Aquaporin4 on the surface of brain cells. Int J Med Sci 20(6):797\u2013809. https:\/\/doi.org\/10.7150\/ijms.82677","journal-title":"Int J Med Sci"},{"key":"5072_CR25","doi-asserted-by":"publisher","unstructured":"Liu L, Duff K (2008) A technique for serial collection of cerebrospinal fluid from the cisterna magna in mouse. Journal of visualized experiments : JoVE (21). https:\/\/doi.org\/10.3791\/960","DOI":"10.3791\/960"},{"key":"5072_CR26","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jare.2023.03.004","volume":"56","author":"X Si","year":"2024","unstructured":"Si X, Dai S, Fang Y, Tang J, Wang Z, Li Y, Song Z, Chen Y, Liu Y, Zhao G, Zhang B, Pu J (2024) Matrix metalloproteinase-9 inhibition prevents aquaporin-4 depolarization-mediated glymphatic dysfunction in Parkinson\u2019s disease. J Adv Res 56:125\u2013136. https:\/\/doi.org\/10.1016\/j.jare.2023.03.004","journal-title":"J Adv Res"},{"issue":"6","key":"5072_CR27","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1002\/ana.24271","volume":"76","author":"BT Kress","year":"2014","unstructured":"Kress BT, Iliff JJ, Xia M, Wang M, Wei HS, Zeppenfeld D, Xie L, Kang H, Xu Q, Liew JA, Plog BA, Ding F, Deane R, Nedergaard M (2014) Impairment of paravascular clearance pathways in the aging brain. Ann Neurol 76(6):845\u2013861. https:\/\/doi.org\/10.1002\/ana.24271","journal-title":"Ann Neurol"},{"key":"5072_CR28","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03212-2","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Zhang C, He XZ, Li ZH, Meng JC, Mao RT, Li X, Xue R, Gui Q, Zhang GX, Wang LH (2023) Interaction Between the Glymphatic System and \u03b1-Synuclein in Parkinson\u2019s Disease. Mol Neurobiol. https:\/\/doi.org\/10.1007\/s12035-023-03212-2","journal-title":"Mol Neurobiol"},{"issue":"49","key":"5072_CR29","doi-asserted-by":"publisher","first-page":"16180","DOI":"10.1523\/jneurosci.3020-14.2014","volume":"34","author":"JJ Iliff","year":"2014","unstructured":"Iliff JJ, Chen MJ, Plog BA, Zeppenfeld DM, Soltero M, Yang L, Singh I, Deane R, Nedergaard M (2014) Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J Neurosci Official J Soc Neurosci 34(49):16180\u201316193. https:\/\/doi.org\/10.1523\/jneurosci.3020-14.2014","journal-title":"J Neurosci Official J Soc Neurosci"},{"key":"5072_CR30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40035-019-0147-y","volume":"8","author":"W Zou","year":"2019","unstructured":"Zou W, Pu T, Feng W, Lu M, Zheng Y, Du R, Xiao M, Hu G (2019) Blocking meningeal lymphatic drainage aggravates Parkinson\u2019s disease-like pathology in mice overexpressing mutated \u03b1-synuclein. Translational Neurodegen 8:7. https:\/\/doi.org\/10.1186\/s40035-019-0147-y","journal-title":"Translational Neurodegen"},{"issue":"1","key":"5072_CR31","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1001\/jamaneurol.2016.4370","volume":"74","author":"DM Zeppenfeld","year":"2017","unstructured":"Zeppenfeld DM, Simon M, Haswell JD, D\u2019Abreo D, Murchison C, Quinn JF, Grafe MR, Woltjer RL, Kaye J, Iliff JJ (2017) Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains. JAMA Neurol 74(1):91\u201399. https:\/\/doi.org\/10.1001\/jamaneurol.2016.4370","journal-title":"JAMA Neurol"},{"issue":"2","key":"5072_CR32","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.18632\/aging.102736","volume":"12","author":"N Liufu","year":"2020","unstructured":"Liufu N, Liu L, Shen S, Jiang Z, Dong Y, Wang Y, Culley D, Crosby G, Cao M, Shen Y, Marcantonio E, Xie Z, Zhang Y (2020) Anesthesia and surgery induce age-dependent changes in behaviors and microbiota. Aging 12(2):1965\u20131986. https:\/\/doi.org\/10.18632\/aging.102736","journal-title":"Aging"},{"issue":"5","key":"5072_CR33","doi-asserted-by":"publisher","first-page":"e96752","DOI":"10.1371\/journal.pone.0096752","volume":"9","author":"Z Xu","year":"2014","unstructured":"Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z (2014) Peripheral surgical wounding and age-dependent neuroinflammation in mice. PLoS ONE 9(5):e96752. https:\/\/doi.org\/10.1371\/journal.pone.0096752","journal-title":"PLoS ONE"},{"key":"5072_CR34","doi-asserted-by":"publisher","first-page":"1069155","DOI":"10.3389\/fnagi.2023.1069155","volume":"15","author":"S Liu","year":"2023","unstructured":"Liu S, Li H, Shen Y, Zhu W, Wang Y, Wang J, Zhang N, Li C, Xie L, Wu Q (2023) Moxibustion improves hypothalamus Aqp4 polarization in APP\/PS1 mice: Evidence from spatial transcriptomics. Front Aging Neurosci 15:1069155. https:\/\/doi.org\/10.3389\/fnagi.2023.1069155","journal-title":"Front Aging Neurosci"},{"issue":"5","key":"5072_CR35","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.14336\/ad.2022.0219","volume":"13","author":"T Wang","year":"2022","unstructured":"Wang T, Chen Y, Zou Y, Pang Y, He X, Chen Y, Liu Y, Feng W, Zhang Y, Li Q, Shi J, Ding F, Marshall C, Gao J, Xiao M (2022) Locomotor Hyperactivity in the Early-Stage Alzheimer\u2019s Disease-like Pathology of APP\/PS1 Mice: Associated with Impaired Polarization of Astrocyte Aquaporin 4. Aging Dis 13(5):1504\u20131522. https:\/\/doi.org\/10.14336\/ad.2022.0219","journal-title":"Aging Dis"},{"issue":"2","key":"5072_CR36","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/jnr.24082","volume":"96","author":"MJ Simon","year":"2018","unstructured":"Simon MJ, Murchison C, Iliff JJ (2018) A transcriptome-based assessment of the astrocytic dystrophin-associated complex in the developing human brain. J Neurosci Res 96(2):180\u2013193. https:\/\/doi.org\/10.1002\/jnr.24082","journal-title":"J Neurosci Res"},{"key":"5072_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.03.004","author":"X Si","year":"2023","unstructured":"Si X, Dai S, Fang Y, Tang J, Wang Z, Li Y, Song Z, Chen Y, Liu Y, Zhao G, Zhang B, Pu J (2023) Matrix metalloproteinase-9 inhibition prevents aquaporin-4 depolarization-mediated glymphatic dysfunction in Parkinson\u2019s disease. J Adv Res. https:\/\/doi.org\/10.1016\/j.jare.2023.03.004","journal-title":"J Adv Res"},{"key":"5072_CR38","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neuroscience.2022.11.033","volume":"510","author":"C Chen","year":"2023","unstructured":"Chen C, Fan P, Zhang L, Xue K, Hu J, Huang J, Lu W, Xu J, Xu S, Qiu G, Ran J, Gan S (2023) Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing \u03b2-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion Injury. Neuroscience 510:95\u2013108. https:\/\/doi.org\/10.1016\/j.neuroscience.2022.11.033","journal-title":"Neuroscience"},{"issue":"2","key":"5072_CR39","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1523\/jneurosci.1797-17.2017","volume":"38","author":"T Femen\u00eda","year":"2018","unstructured":"Femen\u00eda T, Gim\u00e9nez-Cassina A, Codeluppi S, Fern\u00e1ndez-Zafra T, Katsu-Jim\u00e9nez Y, Terrando N, Eriksson LI, G\u00f3mez-Gal\u00e1n M (2018) Disrupted Neuroglial Metabolic Coupling after Peripheral Surgery. J Neurosci Official J Soc Neurosci 38(2):452\u2013464. https:\/\/doi.org\/10.1523\/jneurosci.1797-17.2017","journal-title":"J Neurosci Official J Soc Neurosci"},{"issue":"4","key":"5072_CR40","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.1007\/s13311-021-01126-2","volume":"18","author":"H Jeon","year":"2021","unstructured":"Jeon H, Kim M, Park W, Lim JS, Lee E, Cha H, Ahn JS, Kim JH, Hong SH, Park JE, Lee EJ, Woo CW, Lee S (2021) Upregulation of AQP4 Improves Blood-Brain Barrier Integrity and Perihematomal Edema Following Intracerebral Hemorrhage. Neurotherapeutics J American Soc Exp NeuroTherapeutics 18(4):2692\u20132706. https:\/\/doi.org\/10.1007\/s13311-021-01126-2","journal-title":"Neurotherapeutics J American Soc Exp NeuroTherapeutics"},{"key":"5072_CR41","doi-asserted-by":"publisher","first-page":"659457","DOI":"10.3389\/fnagi.2021.659457","volume":"13","author":"X Ren","year":"2021","unstructured":"Ren X, Liu S, Lian C, Li H, Li K, Li L, Zhao G (2021) Dysfunction of the Glymphatic System as a Potential Mechanism of Perioperative Neurocognitive Disorders. Frontiers in aging neuroscience 13:659457. https:\/\/doi.org\/10.3389\/fnagi.2021.659457","journal-title":"Frontiers in aging neuroscience"},{"key":"5072_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2015.05.042","volume":"1622","author":"WC Yang","year":"2015","unstructured":"Yang WC, Zhou LJ, Zhang R, Yue ZY, Dong H, Song CY, Qian H, Lu SJ, Chang FF (2015) Effects of propofol and sevoflurane on aquaporin-4 and aquaporin-9 expression in patients performed gliomas resection. Brain Res 1622:1\u20136. https:\/\/doi.org\/10.1016\/j.brainres.2015.05.042","journal-title":"Brain Res"},{"issue":"8","key":"5072_CR43","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1002\/glia.22317","volume":"60","author":"DK Binder","year":"2012","unstructured":"Binder DK, Nagelhus EA, Ottersen OP (2012) Aquaporin-4 and epilepsy. Glia 60(8):1203\u20131214. https:\/\/doi.org\/10.1002\/glia.22317","journal-title":"Glia"},{"issue":"3","key":"5072_CR44","doi-asserted-by":"publisher","first-page":"e0282955","DOI":"10.1371\/journal.pone.0282955","volume":"18","author":"A Alghanimy","year":"2023","unstructured":"Alghanimy A, Martin C, Gallagher L, Holmes WM (2023) The effect of a novel AQP4 facilitator, TGN-073, on glymphatic transport captured by diffusion MRI and DCE-MRI. PLoS ONE 18(3):e0282955. https:\/\/doi.org\/10.1371\/journal.pone.0282955","journal-title":"PLoS ONE"},{"key":"5072_CR45","doi-asserted-by":"publisher","first-page":"101583","DOI":"10.1016\/j.smrv.2021.101583","volume":"61","author":"SL Chellappa","year":"2022","unstructured":"Chellappa SL, Aeschbach D (2022) Sleep and anxiety: From mechanisms to interventions. Sleep Med Rev 61:101583. https:\/\/doi.org\/10.1016\/j.smrv.2021.101583","journal-title":"Sleep Med Rev"},{"issue":"9","key":"5072_CR46","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1093\/brain\/awac289","volume":"145","author":"MJ Giannetto","year":"2022","unstructured":"Giannetto MJ, Hablitz LM (2022) Reading to the end(foot): translational readthrough of AQP4 increases amyloid-\u03b2 clearance. Brain J Neurology 145(9):2943\u20132945. https:\/\/doi.org\/10.1093\/brain\/awac289","journal-title":"Brain J Neurology"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05072-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-05072-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05072-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:02:39Z","timestamp":1757786559000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-05072-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,27]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["5072"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-05072-4","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,27]]},"assertion":[{"value":"17 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We confirmed that both experiments were approved by the Experimental Animal Ethics Committee of Ningbo University (NO12571). We have read through the whole manuscript and ensured all methods were carried out according to relevant guidelines and regulations under the ethics of declaration section along with the approval and arrive guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}