{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:15:32Z","timestamp":1790061332669,"version":"4.0.1"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF2023R1A2C1008079"],"award-info":[{"award-number":["NRF2023R1A2C1008079"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1A4A1025557"],"award-info":[{"award-number":["2022R1A4A1025557"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Brain Korea 21 FOUR","award":["5199990614277"],"award-info":[{"award-number":["5199990614277"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["NRF2022R1A2C1003638"],"award-info":[{"award-number":["NRF2022R1A2C1003638"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s12035-025-05173-0","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T07:01:45Z","timestamp":1751439705000},"page":"13840-13857","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Efficacy of Intrathecal Platelet-Rich Plasma Administration in Alleviation of Chronic Neuropathic Pain in Rat Model"],"prefix":"10.1007","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5416-8608","authenticated-orcid":false,"given":"Jaisan","family":"Islam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9186-8336","authenticated-orcid":false,"given":"Preeti Kumari","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1030-5655","authenticated-orcid":false,"given":"Sanggu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5039-2733","authenticated-orcid":false,"given":"Elina","family":"KC","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7685-6292","authenticated-orcid":false,"given":"Young Seok","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6739-9787","authenticated-orcid":false,"given":"Soochong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"5173_CR1","doi-asserted-by":"publisher","first-page":"174480692094368","DOI":"10.1177\/1744806920943685","volume":"16","author":"J Islam","year":"2020","unstructured":"Islam J, Kc E, Oh BH, Moon HC, Park YS (2020) Pain modulation effect on motor cortex after optogenetic stimulation in shPKC\u03b3 knockdown dorsal root ganglion-compressed Sprague-Dawley rat model. Mol Pain 16:1744806920943685","journal-title":"Mol Pain"},{"key":"5173_CR2","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1007\/s12264-012-1276-9","volume":"28","author":"X-Y Lin","year":"2012","unstructured":"Lin X-Y, Yang J, Li H-M, Hu S-J, Xing J-L (2012) Dorsal root ganglion compression as an animal model of sciatica and low back pain. Neurosci Bull 28:618\u2013630","journal-title":"Neurosci Bull"},{"issue":"10","key":"5173_CR3","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1111\/pme.12413","volume":"15","author":"ES Krames","year":"2014","unstructured":"Krames ES (2014) The role of the dorsal root ganglion in the development of neuropathic pain. Pain Med 15(10):1669\u20131685","journal-title":"Pain Med"},{"issue":"6","key":"5173_CR4","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.1152\/jn.1999.82.6.3347","volume":"82","author":"X-J Song","year":"1999","unstructured":"Song X-J, Hu S-J, Greenquist KW, Zhang J-M, LaMotte RH (1999) Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia. J Neurophysiol 82(6):3347\u20133358","journal-title":"J Neurophysiol"},{"key":"5173_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.neulet.2018.04.003","volume":"676","author":"JBP Lemes","year":"2018","unstructured":"Lemes JBP, de Campos LT, Santos DO, Neves AF, de Oliveira FS, Parada CA, da Cruz Lotufo CM (2018) Participation of satellite glial cells of the dorsal root ganglia in acute nociception. Neurosci Lett 676:8\u201312","journal-title":"Neurosci Lett"},{"key":"5173_CR6","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.brainres.2012.03.070","volume":"1487","author":"M Hanani","year":"2012","unstructured":"Hanani M (2012) Intercellular communication in sensory ganglia by purinergic receptors and gap junctions: implications for chronic pain. Brain Res 1487:183\u2013191","journal-title":"Brain Res"},{"key":"5173_CR7","doi-asserted-by":"publisher","first-page":"158","DOI":"10.3389\/fncel.2018.00158","volume":"12","author":"C Penas","year":"2018","unstructured":"Penas C, Navarro X (2018) Epigenetic modifications associated to neuroinflammation and neuropathic pain after neural trauma. Front Cell Neurosci 12:158","journal-title":"Front Cell Neurosci"},{"issue":"11","key":"5173_CR8","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/s41583-019-0218-1","volume":"20","author":"R-R Ji","year":"2019","unstructured":"Ji R-R, Donnelly CR, Nedergaard M (2019) Astrocytes in chronic pain and itch. Nat Rev Neurosci 20(11):667\u2013685","journal-title":"Nat Rev Neurosci"},{"issue":"9","key":"5173_CR9","doi-asserted-by":"publisher","first-page":"e6973","DOI":"10.1371\/journal.pone.0006973","volume":"4","author":"W Wang","year":"2009","unstructured":"Wang W, Wang W, Mei X, Huang J, Wei Y, Wang Y, Wu S, Li Y (2009) Crosstalk between spinal astrocytes and neurons in nerve injury-induced neuropathic pain. PLoS ONE 4(9):e6973","journal-title":"PLoS ONE"},{"issue":"11","key":"5173_CR10","doi-asserted-by":"publisher","first-page":"6022","DOI":"10.3390\/ijms23116022","volume":"23","author":"PK Chaudhary","year":"2022","unstructured":"Chaudhary PK, Kim S, Kim S (2022) An insight into recent advances on platelet function in health and disease. Int J Mol Sci 23(11):6022","journal-title":"Int J Mol Sci"},{"issue":"7","key":"5173_CR11","doi-asserted-by":"publisher","first-page":"e40831","DOI":"10.1371\/journal.pone.0040831","volume":"7","author":"MC Phipps","year":"2012","unstructured":"Phipps MC, Xu Y, Bellis SL (2012) Delivery of platelet-derived growth factor as a chemotactic factor for mesenchymal stem cells by bone-mimetic electrospun scaffolds. PLoS ONE 7(7):e40831","journal-title":"PLoS ONE"},{"issue":"12","key":"5173_CR12","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.3346\/jkms.2012.27.12.1604","volume":"27","author":"JY Kim","year":"2012","unstructured":"Kim JY, Seo SH, Ahn HH, Kye YC, Choi JE (2012) Recalcitrant cutaneous ulcer of comorbid patient treated with platelet rich plasma: a case report. J Korean Med Sci 27(12):1604\u20131606","journal-title":"J Korean Med Sci"},{"issue":"6","key":"5173_CR13","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1177\/0363546512442334","volume":"40","author":"JL Dragoo","year":"2012","unstructured":"Dragoo JL, Braun HJ, Durham JL, Ridley BA, Odegaard JI, Luong R, Arnoczky SP (2012) Comparison of the acute inflammatory response of two commercial platelet-rich plasma systems in healthy rabbit tendons. Am J Sports Med 40(6):1274\u20131281","journal-title":"Am J Sports Med"},{"issue":"8","key":"5173_CR14","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1302\/0301-620X.91B8.22546","volume":"91","author":"J Alsousou","year":"2009","unstructured":"Alsousou J, Thompson M, Hulley P, Noble A, Willett K (2009) The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature. J Bone Joint Surg British 91(8):987\u2013996","journal-title":"J Bone Joint Surg British"},{"issue":"2","key":"5173_CR15","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1002\/ejp.1119","volume":"22","author":"F Forouzanfar","year":"2018","unstructured":"Forouzanfar F, Amin B, Ghorbani A, Ghazavi H, Ghasemi F, Sadri K, Mehri S, Sadeghnia H et al (2018) New approach for the treatment of neuropathic pain: Fibroblast growth factor 1 gene-transfected adipose-derived mesenchymal stem cells. Eur J Pain 22(2):295\u2013310","journal-title":"Eur J Pain"},{"issue":"9","key":"5173_CR16","doi-asserted-by":"publisher","first-page":"5119","DOI":"10.1096\/fj.201800476R","volume":"32","author":"B Nho","year":"2018","unstructured":"Nho B, Lee J, Lee J, Ko KR, Lee SJ, Kim S (2018) Effective control of neuropathic pain by transient expression of hepatocyte growth factor in a mouse chronic constriction injury model. FASEB J 32(9):5119","journal-title":"FASEB J"},{"issue":"5","key":"5173_CR17","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1177\/0363546519827947","volume":"47","author":"M Baria","year":"2019","unstructured":"Baria M, Vasileff WK, Miller M, Borchers J, Flanigan DC, Durgam SS (2019) Cellular components and growth factor content of platelet-rich plasma with a customizable commercial system. Am J Sports Med 47(5):1216\u20131222","journal-title":"Am J Sports Med"},{"issue":"25","key":"5173_CR18","doi-asserted-by":"publisher","first-page":"18194","DOI":"10.1074\/jbc.M113.461087","volume":"288","author":"S Kim","year":"2013","unstructured":"Kim S, Cipolla L, Guidetti G, Okigaki M, Jin J, Torti M, Kunapuli SP (2013) Distinct role of Pyk2 in mediating thromboxane generation downstream of both G12\/13 and integrin \u03b1IIb\u03b23 in platelets. J Biol Chem 288(25):18194\u201318203","journal-title":"J Biol Chem"},{"key":"5173_CR19","first-page":"e57071","volume":"134","author":"J Prado","year":"2018","unstructured":"Prado J, Popov-Celeketic J, Steen-Louws C, Raoof R, Hack E, Eijkelkamp N (2018) Development of recombinant proteins to treat chronic pain. JoVE (J Visualized Exp) 134:e57071","journal-title":"JoVE (J Visualized Exp)"},{"key":"5173_CR20","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1007\/s12031-020-01685-7","volume":"71","author":"K Elina","year":"2021","unstructured":"Elina K, Moon HC, Islam J, Kim HK, Park YS (2021) The effect of optogenetic inhibition of the anterior cingulate cortex in neuropathic pain following sciatic nerve injury. J Mol Neurosci 71:638\u2013650","journal-title":"J Mol Neurosci"},{"key":"5173_CR21","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.neulet.2017.10.019","volume":"662","author":"HC Moon","year":"2018","unstructured":"Moon HC, Won SY, Kim EG, Kim HK, Cho CB, Park YS (2018) Effect of optogenetic modulation on entopeduncular input affects thalamic discharge and behavior in an AAV2-\u03b1-synuclein-induced hemiparkinson rat model. Neurosci Lett 662:129\u2013135","journal-title":"Neurosci Lett"},{"issue":"4","key":"5173_CR22","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1007\/s12017-023-08752-3","volume":"25","author":"J Islam","year":"2023","unstructured":"Islam J, Kc E, Kim S, Chung MY, Park KS, Kim HK, Park YS (2023) Optogenetic Inhibition of Glutamatergic Neurons in the dysgranular posterior insular cortex modulates Trigeminal Neuropathic Pain in CCI-ION rat. NeuroMol Med 25(4):516\u2013532","journal-title":"NeuroMol Med"},{"issue":"1","key":"5173_CR23","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/s41598-023-27610-7","volume":"13","author":"J Islam","year":"2023","unstructured":"Islam J, Kc E, So KH, Kim S, Kim HK, Park YY, Park YS (2023) Modulation of trigeminal neuropathic pain by optogenetic inhibition of posterior hypothalamus in CCI-ION rat. Sci Rep 13(1):489","journal-title":"Sci Rep"},{"key":"5173_CR24","volume-title":"The rat brain in stereotaxic coordinates: hard","author":"G Paxinos","year":"2006","unstructured":"Paxinos G, Watson C (2006) The rat brain in stereotaxic coordinates: hard, cover. Elsevier","edition":"cover"},{"issue":"4","key":"5173_CR25","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/cne.902960402","volume":"296","author":"E Bullitt","year":"1990","unstructured":"Bullitt E (1990) Expression of c-fos-like protein as a marker for neuronal activity following noxious stimulation in the rat. J Comp Neurol 296(4):517\u2013530","journal-title":"J Comp Neurol"},{"issue":"1","key":"5173_CR26","first-page":"3","volume":"9","author":"AH Ahmad","year":"2002","unstructured":"Ahmad AH, Ismail Z (2002) c-fos and its Consequences in Pain. Malaysian J Med Sci: MJMS 9(1):3","journal-title":"Malaysian J Med Sci: MJMS"},{"key":"5173_CR27","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s00210-011-0721-z","volume":"385","author":"A Romero","year":"2012","unstructured":"Romero A, Gonzalez-Cuello A, Laorden M, Campillo A, Vasconcelos N, Romero-Alejo E, Puig M (2012) Effects of surgery and\/or remifentanil administration on the expression of pERK1\/2, c-Fos and dynorphin in the dorsal root ganglia in mice. Naunyn Schmiedebergs Arch Pharmacol 385:397\u2013409","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"5173_CR28","doi-asserted-by":"publisher","first-page":"134378","DOI":"10.1016\/j.neulet.2019.134378","volume":"709","author":"AF Pereira","year":"2019","unstructured":"Pereira AF, Pereira LMS, Silva CMP, Alves BWF, Barbosa JS, Pinto FMM, Pereira AC, Silva KO et al (2019) Metformin reduces c-Fos and ATF3 expression in the dorsal root ganglia and protects against oxaliplatin-induced peripheral sensory neuropathy in mice. Neurosci Lett 709:134378","journal-title":"Neurosci Lett"},{"key":"5173_CR29","first-page":"1933","volume":"9","author":"S Rama","year":"1853","unstructured":"Rama S, Zbili M (1853) Debanne D (2015) Modulation of spike-evoked synaptic transmission: The role of presynaptic calcium and potassium channels. Biochimica et Biophysica Acta (BBA)-Mol Cell Res 9:1933\u20131939","journal-title":"Biochimica et Biophysica Acta (BBA)-Mol Cell Res"},{"key":"5173_CR30","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3389\/fncel.2019.00513","volume":"13","author":"LA Cingolani","year":"2019","unstructured":"Cingolani LA, Vitale C, Dityatev A (2019) Intra-and extracellular pillars of a unifying framework for homeostatic plasticity: a crosstalk between metabotropic receptors and extracellular matrix. Front Cell Neurosci 13:513","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"5173_CR31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s10194-025-01977-6","volume":"26","author":"J Islam","year":"2025","unstructured":"Islam J, Rahman MT, Ali M, Kim HK, Kc E, Park YS (2025) Optogenetic inhibition of ventrolateral orbitofrontal cortex astrocytes facilitates ventrolateral periaqueductal gray glutamatergic activity to reduce hypersensitivity in infraorbital nerve injury rat model. J Headache Pain 26(1):41","journal-title":"J Headache Pain"},{"issue":"4","key":"5173_CR32","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.bbrc.2010.04.086","volume":"395","author":"W Tong","year":"2010","unstructured":"Tong W, Wang W, Huang J, Ren N, Wu S-X, Li Y-Q (2010) Spinal high-mobility group box 1 contributes to mechanical allodynia in a rat model of bone cancer pain. Biochem Biophys Res Commun 395(4):572\u2013576","journal-title":"Biochem Biophys Res Commun"},{"key":"5173_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s10194-018-0836-4","volume":"19","author":"B Wang","year":"2018","unstructured":"Wang B, Liu S, Fan B, Xu X, Chen Y, Lu R, Xu Z, Liu X (2018) PKM2 is involved in neuropathic pain by regulating ERK and STAT3 activation in rat spinal cord. J Headache Pain 19:1\u20139","journal-title":"J Headache Pain"},{"issue":"2","key":"5173_CR34","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","volume":"139","author":"AI Basbaum","year":"2009","unstructured":"Basbaum AI, Bautista DM, Scherrer G, Julius D (2009) Cellular and molecular mechanisms of pain. Cell 139(2):267\u2013284","journal-title":"Cell"},{"issue":"1","key":"5173_CR35","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.bbr.2009.11.034","volume":"208","author":"X-L Ding","year":"2010","unstructured":"Ding X-L, Wang Y-H, Ning L-P, Zhang Y, Ge H-Y, Jiang H, Wang R, Yue S-W (2010) Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats. Behav Brain Res 208(1):194\u2013201","journal-title":"Behav Brain Res"},{"issue":"5","key":"5173_CR36","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1159\/000276981","volume":"85","author":"X-J Wen","year":"2010","unstructured":"Wen X-J, Xu S-Y, Chen Z-X, Yang C-X, Liang H, Li H (2010) The roles of T-type calcium channel in the development of neuropathic pain following chronic compression of rat dorsal root ganglia. Pharmacology 85(5):295\u2013300","journal-title":"Pharmacology"},{"issue":"3","key":"5173_CR37","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1111\/j.1471-4159.2006.03746.x","volume":"97","author":"J Zhang","year":"2006","unstructured":"Zhang J, De Koninck Y (2006) Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury. J Neurochem 97(3):772\u2013783","journal-title":"J Neurochem"},{"issue":"1","key":"5173_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0006-8993(91)91729-K","volume":"565","author":"C Garrison","year":"1991","unstructured":"Garrison C, Dougherty P, Kajander K, Carlton S (1991) Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury. Brain Res 565(1):1\u20137","journal-title":"Brain Res"},{"issue":"6","key":"5173_CR39","doi-asserted-by":"publisher","first-page":"738","DOI":"10.2174\/1381612822666151204001234","volume":"22","author":"M Habibur Rahman","year":"2016","unstructured":"Habibur Rahman M, Kumar Jha M, Suk K (2016) Evolving insights into the pathophysiology of diabetic neuropathy: implications of malfunctioning glia and discovery of novel therapeutic targets. Curr Pharm Des 22(6):738\u2013757","journal-title":"Curr Pharm Des"},{"issue":"7","key":"5173_CR40","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1038\/sj.bjp.0705724","volume":"141","author":"JG Chichorro","year":"2004","unstructured":"Chichorro JG, Lorenzetti BB, Zampronio AR (2004) Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin-induced orofacial nociception in rats. Br J Pharmacol 141(7):1175\u20131184","journal-title":"Br J Pharmacol"},{"issue":"4","key":"5173_CR41","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1111\/j.1471-4159.2005.03462.x","volume":"95","author":"O Nesic","year":"2005","unstructured":"Nesic O, Lee J, Johnson KM, Ye Z, Xu GY, Unabia GC, Wood TG, McAdoo DJ et al (2005) Transcriptional profiling of spinal cord injury-induced central neuropathic pain. J Neurochem 95(4):998\u20131014","journal-title":"J Neurochem"},{"issue":"1-3","key":"5173_CR42","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.pain.2009.09.030","volume":"147","author":"SM Carlton","year":"2009","unstructured":"Carlton SM, Du J, Tan HY, Nesic O, Hargett GL, Bopp AC, Yamani A, Lin Q et al (2009) Peripheral and central sensitization in remote spinal cord regions contribute to central neuropathic pain after spinal cord injury. Pain\u00ae 147(1\u20133):265\u2013276","journal-title":"Pain\u00ae"},{"issue":"32","key":"5173_CR43","doi-asserted-by":"publisher","first-page":"10833","DOI":"10.1523\/JNEUROSCI.5628-11.2012","volume":"32","author":"Y Shi","year":"2012","unstructured":"Shi Y, Gelman BB, Lisinicchia JG, Tang S-J (2012) Chronic-pain-associated astrocytic reaction in the spinal cord dorsal horn of human immunodeficiency virus-infected patients. J Neurosci 32(32):10833\u201310840","journal-title":"J Neurosci"},{"issue":"1","key":"5173_CR44","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.bbi.2008.08.004","volume":"23","author":"L Del Valle","year":"2009","unstructured":"Del Valle L, Schwartzman RJ, Alexander G (2009) Spinal cord histopathological alterations in a patient with longstanding complex regional pain syndrome. Brain Behav Immun 23(1):85\u201391","journal-title":"Brain Behav Immun"},{"issue":"1","key":"5173_CR45","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s10194-023-01669-z","volume":"24","author":"E Kc","year":"2023","unstructured":"Kc E, Islam J, Kim HK, Park YS (2023) GFAP-NpHR mediated optogenetic inhibition of trigeminal nucleus caudalis attenuates hypersensitive behaviors and thalamic discharge attributed to infraorbital nerve constriction injury. J Headache Pain 24(1):137","journal-title":"J Headache Pain"},{"issue":"4","key":"5173_CR46","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.nurt.2010.05.016","volume":"7","author":"Y-J Gao","year":"2010","unstructured":"Gao Y-J, Ji R-R (2010) Targeting astrocyte signaling for chronic pain. Neurotherapeutics 7(4):482\u2013493","journal-title":"Neurotherapeutics"},{"issue":"36","key":"5173_CR47","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","volume":"34","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O\u2019Keeffe S, Phatnani HP, Guarnieri P et al (2014) An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci 34(36):11929\u201311947","journal-title":"J Neurosci"},{"issue":"12","key":"5173_CR48","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1080\/00365520500319112","volume":"40","author":"J Walkowiak","year":"2005","unstructured":"Walkowiak J, Banasiewicz T, Krokowicz P, Hansdorfer-Korzon R, Drews M, Herzig K-H (2005) Fecal pyruvate kinase (M2-PK): a new predictor for inflammation and severity of pouchitis. Scand J Gastroenterol 40(12):1493\u20131494","journal-title":"Scand J Gastroenterol"},{"key":"5173_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1742-2094-9-180","volume":"9","author":"P Feldman","year":"2012","unstructured":"Feldman P, Due MR, Ripsch MS, Khanna R, White FA (2012) The persistent release of HMGB1 contributes to tactile hyperalgesia in a rodent model of neuropathic pain. J Neuroinflammation 9:1\u201311","journal-title":"J Neuroinflammation"},{"key":"5173_CR50","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s13258-019-00904-9","volume":"42","author":"C Liu","year":"2020","unstructured":"Liu C, Yang J, Liu H, Xia T, Zhang F (2020) miR-300 mitigates cancer-induced bone pain through targeting HMGB1 in rat models. Genes Genomics 42:309\u2013316","journal-title":"Genes Genomics"},{"issue":"6","key":"5173_CR51","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1189\/jlb.72.6.1084","volume":"72","author":"U Andersson","year":"2002","unstructured":"Andersson U, Erlandsson-Harris H, Yang H, Tracey KJ (2002) HMGB1 as a DNA-binding cytokine. J Leukoc Biol 72(6):1084\u20131091","journal-title":"J Leukoc Biol"},{"issue":"21","key":"5173_CR52","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.21037\/atm-20-6502","volume":"8","author":"X Wei","year":"2020","unstructured":"Wei X, Jin X-H, Meng X-W, Hua J, Ji F-H, Wang L-N, Yang J-P (2020) Platelet-rich plasma improves chronic inflammatory pain by inhibiting PKM2-mediated aerobic glycolysis in astrocytes. Annals Transl Med 8(21):1456","journal-title":"Annals Transl Med"},{"issue":"7","key":"5173_CR53","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.3390\/ijms17071064","volume":"17","author":"E Monta\u00f1ez-Heredia","year":"2016","unstructured":"Monta\u00f1ez-Heredia E, Ir\u00edzar S, Huertas PJ, Otero E, Del Valle M, Prat I, D\u00edaz-Gallardo MS, Per\u00e1n M et al (2016) Intra-articular injections of platelet-rich plasma versus hyaluronic acid in the treatment of osteoarthritic knee pain: a randomized clinical trial in the context of the Spanish National Health Care System. Int J Mol Sci 17(7):1064","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5173_CR54","first-page":"199","volume":"100","author":"NN Knezevic","year":"2016","unstructured":"Knezevic NN, Candido KD, Desai R, Kaye AD (2016) Is platelet-rich plasma a future therapy in pain management? Medical Clinics 100(1):199\u2013217","journal-title":"Medical Clinics"},{"issue":"1","key":"5173_CR55","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/ejp.1846","volume":"26","author":"Y Bohren","year":"2022","unstructured":"Bohren Y, Timbolschi DI, Muller A, Barrot M, Yalcin I, Salvat E (2022) Platelet-rich plasma and cytokines in neuropathic pain: A narrative review and a clinical perspective. Eur J Pain 26(1):43\u201360","journal-title":"Eur J Pain"},{"issue":"4","key":"5173_CR56","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1902\/jop.2007.060302","volume":"78","author":"H El-Sharkawy","year":"2007","unstructured":"El-Sharkawy H, Kantarci A, Deady J, Hasturk H, Liu H, Alshahat M, Van Dyke TE (2007) Platelet-rich plasma: growth factors and pro-and anti-inflammatory properties. J Periodontol 78(4):661\u2013669","journal-title":"J Periodontol"},{"issue":"1","key":"5173_CR57","doi-asserted-by":"publisher","first-page":"81","DOI":"10.7150\/thno.16803","volume":"7","author":"S-C Guo","year":"2017","unstructured":"Guo S-C, Tao S-C, Yin W-J, Qi X, Yuan T, Zhang C-Q (2017) Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model. Theranostics 7(1):81","journal-title":"Theranostics"},{"issue":"4","key":"5173_CR58","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1080\/09537104.2019.1663805","volume":"31","author":"MC Cakin","year":"2020","unstructured":"Cakin MC, Ozdemir B, Kaya-Dagistanli F, Arkan H, Bahtiyar N, Anapali M, Akbas F, Onaran I (2020) Evaluation of the in vivo wound healing potential of the lipid fraction from activated platelet-rich plasma. Platelets 31(4):513\u2013520","journal-title":"Platelets"},{"issue":"1","key":"5173_CR59","first-page":"1019","volume":"2","author":"D Aufiero","year":"2015","unstructured":"Aufiero D, Vincent H, Sampson S, Bodor M (2015) Regenerative injection treatment in the spine: review and case series with platelet rich plasma. J Stem Cells Res Rev & Rep 2(1):1019","journal-title":"J Stem Cells Res Rev & Rep"},{"issue":"4","key":"5173_CR60","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1093\/pm\/pnz140","volume":"21","author":"M Hassanien","year":"2020","unstructured":"Hassanien M, Elawamy A, Kamel EZ, Khalifa WA, Abolfadl GM, Roushdy ASI, El Zohne RA, Makarem YS (2020) Perineural platelet-rich plasma for diabetic neuropathic pain, could it make a difference? Pain Med 21(4):757\u2013765","journal-title":"Pain Med"},{"issue":"5","key":"5173_CR61","first-page":"263","volume":"25","author":"JC L\u00f3pez","year":"2018","unstructured":"L\u00f3pez JC, Cort\u00e9s H, Garc\u00eda-Ceballos E, Quintero-Pizarro L (2018) Platelet-rich plasma in treating peripheral neuropathic pain. Preliminary report. Revista de la Sociedad Espa\u00f1ola del Dolor (SED) 25(5):263\u2013270","journal-title":"Revista de la Sociedad Espa\u00f1ola del Dolor (SED)"},{"issue":"4","key":"5173_CR62","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/jor.22532","volume":"32","author":"HJ Kim","year":"2014","unstructured":"Kim HJ, Yeom JS, Koh YG, Yeo JE, Kang KT, Kang YM, Chang BS, Lee CK (2014) Anti-inflammatory effect of platelet-rich plasma on nucleus pulposus cells with response of TNF-\u03b1 and IL-1. J Orthop Res 32(4):551\u2013556","journal-title":"J Orthop Res"},{"key":"5173_CR63","doi-asserted-by":"crossref","unstructured":"Hunter CW, Yang A (2019) Scientific Bases of PRP Therapy. In: Deer's Treatment of Pain: An Illustrated Guide for Practitioners. Springer, pp 709\u2013714","DOI":"10.1007\/978-3-030-12281-2_87"},{"issue":"10","key":"5173_CR64","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1007\/s11916-022-01078-y","volume":"26","author":"AD Kaye","year":"2022","unstructured":"Kaye AD, Edinoff AN, Rosen YE, Boudreaux MA, Kaye AJ, Sheth M, Cornett EM, Moll V et al (2022) Regenerative medicine: pharmacological considerations and clinical role in pain management. Curr Pain Headache Rep 26(10):751\u2013765","journal-title":"Curr Pain Headache Rep"},{"key":"5173_CR65","doi-asserted-by":"publisher","first-page":"e81463","DOI":"10.7554\/eLife.81463","volume":"12","author":"O Kotler","year":"2023","unstructured":"Kotler O, Khrapunsky Y, Shvartsman A, Dai H, Plant LD, Goldstein SA, Fleidervish I (2023) SUMOylation of NaV1. 2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons. Elife 12:e81463","journal-title":"Elife"},{"issue":"20","key":"5173_CR66","doi-asserted-by":"publisher","first-page":"7533","DOI":"10.3390\/ijms21207533","volume":"21","author":"A Anjum","year":"2020","unstructured":"Anjum A, Yazid MDI, FauziDaud M, Idris J, Nangg AMH, SelviNaicker A, Ismail OHR, AthiKumar RK et al (2020) Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms. Int J Mol Sci 21(20):7533","journal-title":"Int J Mol Sci"},{"issue":"2009","key":"5173_CR67","doi-asserted-by":"publisher","first-page":"769","DOI":"10.2741\/3277","volume":"14","author":"PD Dalton","year":"2009","unstructured":"Dalton PD, Mey J (2009) Neural interactions with materials. Front Biosci 14(2009):769\u2013795","journal-title":"Front Biosci"},{"key":"5173_CR68","unstructured":"Parisio C (2022) VEGF-A\/VEGFRs system in neuropathies: a crossroad between pain and neuroprotection."},{"issue":"3","key":"5173_CR69","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1002\/jcp.22274","volume":"225","author":"P Bendinelli","year":"2010","unstructured":"Bendinelli P, Matteucci E, Dogliotti G, Corsi MM, Banfi G, Maroni P, Desiderio MA (2010) Molecular basis of anti-inflammatory action of platelet-rich plasma on human chondrocytes: Mechanisms of NF-\u03baB inhibition via HGF. J Cell Physiol 225(3):757\u2013766","journal-title":"J Cell Physiol"},{"key":"5173_CR70","doi-asserted-by":"crossref","unstructured":"Akeda K, Yamada J, Linn ET, Sudo A, Masuda K (2019) Platelet-rich plasma in the management of chronic low back pain: a critical review. J Pain Res 753\u2013767","DOI":"10.2147\/JPR.S153085"},{"issue":"3","key":"5173_CR71","doi-asserted-by":"publisher","first-page":"238","DOI":"10.7150\/ijms.22563","volume":"15","author":"S-H Huang","year":"2018","unstructured":"Huang S-H, Wu S-H, Lee S-S, Lin Y-N, Chai C-Y, Lai C-S, Wang H-MD (2018) Platelet-rich plasma injection in burn scar areas alleviates neuropathic scar pain. Int J Med Sci 15(3):238","journal-title":"Int J Med Sci"},{"issue":"6","key":"5173_CR72","doi-asserted-by":"publisher","first-page":"779","DOI":"10.2217\/pmt-2022-0006","volume":"12","author":"JCd Castro","year":"2022","unstructured":"Castro JCd, Wang D, Chien GCC (2022) Regenerative medicine for neuropathic pain: physiology, ultrasound and therapies with a focus on alpha-2-macroglobulin. Pain Manag 12(6):779\u2013793","journal-title":"Pain Manag"},{"key":"5173_CR73","doi-asserted-by":"publisher","first-page":"695670","DOI":"10.3389\/fnins.2021.695670","volume":"15","author":"B Dou","year":"2021","unstructured":"Dou B, Li Y, Ma J, Xu Z, Fan W, Tian L, Chen Z, Li N, Gong Y, Lyu Z (2021) Role of neuroimmune crosstalk in mediating the anti-inflammatory and analgesic effects of acupuncture on inflammatory pain. Front Neurosci 15:695670","journal-title":"Front Neurosci"},{"key":"5173_CR74","doi-asserted-by":"crossref","unstructured":"Yan S, Wang S, Chen N, Chai D, Wang H, Yang J, Xu Q, Fu S (2025) GO\/Alg\/PRP Regulates Oxidative Stress Through the p38MAPK\/NF-\u03baB Pathway on Ischemic Reperfusion Pressure Injury in Mice.","DOI":"10.20944\/preprints202501.1156.v2"},{"key":"5173_CR75","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez M, Garate A, Bilbao AM, Oraa J, Yang\u00fcela F, S\u00e1nchez P, Guadilla J, Aizpurua B et al (2018) Platelet-rich plasma for injured peripheral nerves: biological repair process and clinical application guidelines. In: Demystifying polyneuropathy-recent advances and new directions. IntechOpen,","DOI":"10.5772\/intechopen.81104"},{"key":"5173_CR76","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1007\/s12015-010-9227-1","volume":"7","author":"M Dadon-Nachum","year":"2011","unstructured":"Dadon-Nachum M, Sadan O, Srugo I, Melamed E, Offen D (2011) Differentiated mesenchymal stem cells for sciatic nerve injury. Stem Cell Rev Rep 7:664\u2013671","journal-title":"Stem Cell Rev Rep"},{"key":"5173_CR77","doi-asserted-by":"crossref","unstructured":"Vickers ER, Karsten E, Flood J, Lilischkis R (2014) A preliminary report on stem cell therapy for neuropathic pain in humans. J Pain Res 255\u2013263","DOI":"10.2147\/JPR.S63361"},{"issue":"19","key":"5173_CR78","doi-asserted-by":"publisher","first-page":"11726","DOI":"10.3390\/ijms231911726","volume":"23","author":"DDMF Jorge","year":"2022","unstructured":"Jorge DDMF, Huber SC, Rodrigues BL, Da Fonseca LF, Azzini GOM, Parada CA, Paulus-Romero C, Lana JFSD (2022) The mechanism of action between pulsed radiofrequency and orthobiologics: Is there a synergistic effect? Int J Mol Sci 23(19):11726","journal-title":"Int J Mol Sci"},{"issue":"1\u20132","key":"5173_CR79","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.pain.2009.02.006","volume":"143","author":"D-s Kim","year":"2009","unstructured":"Kim D-s, Figueroa KW, Li K-W, Boroujerdi A, Yolo T, Luo ZD (2009) Profiling of dynamically changed gene expression in dorsal root ganglia post peripheral nerve injury and a critical role of injury-induced glial fibrillary acetic protein in maintenance of pain behaviors. Pain 143(1\u20132):114\u2013122","journal-title":"Pain"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05173-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-05173-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05173-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:06:31Z","timestamp":1759997191000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-05173-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":79,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["5173"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-05173-0","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]},"assertion":[{"value":"8 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All of our research followed the Animal Care and Use Committee (IACUC) protocols at Chungbuk National University. The title of the approved project was \u201cReciprocal neuromodulation in chronic neuropathic pain rat model\u201d. The project was approved in 2023.01.30 and the approval number is CBNUA-2060\u201323-02. Furthermore, the manuscript adheres to the ARRIVE guidelines for reporting, ensuring comprehensive and transparent documentation of the research conducted. The experimental procedures were performed at the Laboratory Animal Research Center of Chungbuk National University, during daylight hours, with stringent efforts to limit both the distress experienced by the animals and the total number of animals used in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}