{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:46:07Z","timestamp":1793508367108,"version":"4.5.0"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100017160","name":"Beni Suef University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100017160","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alzheimer\u2019s disease (AD) is a progressive age-dependent neurodegenerative disorder associated with oxidative brain damage, disrupted neuronal transmission, memory loss, and behavioral changes, with aluminum being a key environmental risk factor that exacerbates its effect. The aim of this study is to enhance the therapeutic potential of astaxanthin (AST) in Alzheimer\u2019s disease by formulating it into invasomal carriers, with special emphasis on SIRT-1\/BDNF\/miRNA-134\/GSK-3\u03b2 signaling in an AD-like rat model caused by aluminum chloride (AlCl\n                    <jats:sub>3<\/jats:sub>\n                    ) at a dose of 100 mg\/kg\/day for 60 days. Optimum AST-loaded invasomes (AST-LI) were prepared using a formulation of phospholipid: ethanol: cineole as 300 mg: 0.3 ml: 0.1 ml for the production of stable vesicles with high entrapment efficiency and negative zeta potential indicating good stability and de-aggregation. As a SIRT-1 activator, AST-LI supplementation improved learning and memory by alleviating the brain redox status (reduced glutathione; GSH, malondialdehyde; MDA), mitochondrial dysfunction, and inflammatory response linked to amyloid \u03b2 (A\u03b2) clearance and GSK-3\u03b2-mediated p-tau inhibition. It enhanced both spatial and non-spatial short-term memory in rats and restored neurotransmitter levels by raising serotonin and reducing acetylcholinesterase (AChE) and monoamine oxidase (MAO) activities in the brain. Furthermore, AST-LI significantly restored the brain recovery proteins such as Chemokine C-X3-C motif ligand 1 (CX3CL1), glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF), and miRNA-134. These modulations may underlie the observed improvements in oxidative stress, inflammation, apoptosis, and histological outcomes in the AD-like model. In conclusion, improved AST-LI formulations represent promising therapeutic approaches for AD by modulating SIRT-1\/BDNF\/miRNA-134\/GSK-3\u03b2 signaling.\n                  <\/jats:p>","DOI":"10.1007\/s12035-025-05241-5","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T12:26:51Z","timestamp":1754051211000},"page":"16189-16208","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Formulation and Evaluation of Astaxanthin-Loaded Invasomes as Therapeutic Approaches for Alzheimer\u2019s Disease Induced in Rats: Role of SIRT-1\/BDNF\/miRNA-134\/GSK-3\u03b2 Signaling"],"prefix":"10.1007","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4993-4042","authenticated-orcid":false,"given":"Mohamed A.","family":"Kandeil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6890-8731","authenticated-orcid":false,"given":"Eman T.","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-8379","authenticated-orcid":false,"given":"Marwa A.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2063-2809","authenticated-orcid":false,"given":"Rania A.","family":"Radi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0082-4160","authenticated-orcid":false,"given":"Amr","family":"Gamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7982-5827","authenticated-orcid":false,"given":"Abdel-Razik H.","family":"Abdel-Razik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8231-6644","authenticated-orcid":false,"given":"Fatma","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6720-3385","authenticated-orcid":false,"given":"Dina","family":"Sabry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"5241_CR1","doi-asserted-by":"publisher","first-page":"5120230","DOI":"10.1155\/2020\/5120230","volume":"2020","author":"S Maramai","year":"2020","unstructured":"Maramai S, Benchekroun M, Gabr MT, Yahiaoui S (2020) Multitarget therapeutic strategies for Alzheimer\u2019s disease: review on emerging target combinations. BioMed Res Int 2020:5120230","journal-title":"BioMed Res Int"},{"issue":"5","key":"5241_CR2","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/gim.2015.117","volume":"18","author":"C Van Cauwenberghe","year":"2016","unstructured":"Van Cauwenberghe C, Van Broeckhoven C, Sleegers K (2016) The genetic landscape of Alzheimer disease: clinical implications and perspectives. Genet Med 18(5):421\u2013430. https:\/\/doi.org\/10.1038\/gim.2015.117","journal-title":"Genet Med"},{"key":"5241_CR3","doi-asserted-by":"publisher","first-page":"44906","DOI":"10.1007\/s11356-020-10950-6","volume":"27","author":"S Sharma","year":"2020","unstructured":"Sharma S, Wakode S, Sharma A, Nair N, Dhobi M, Wani MA, Pottoo FH (2020) Effect of environmental toxicants on neuronal functions. Environ Sci Pollut Res Int 27:44906\u201344921","journal-title":"Environ Sci Pollut Res Int"},{"key":"5241_CR4","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/978-981-13-1370-7_7","volume":"1091","author":"J Song","year":"2018","unstructured":"Song J (2018) Animal model of aluminum-induced Alzheimer\u2019s disease. Adv Exp Med Biol Actions 1091:113\u2013127","journal-title":"Adv Exp Med Biol Actions"},{"key":"5241_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.ant.2020.12.001","volume":"5","author":"AV Skalny","year":"2021","unstructured":"Skalny AV, Aschner M, Jiang Y, Gluhcheva YG, Tizabi Y, Lobinski R, Tinkov AA (2021) Molecular mechanisms of aluminum neurotoxicity: update on adverse effects and therapeutic strategies. Adv Neurotoxicol 5:1\u201334. https:\/\/doi.org\/10.1016\/bs.ant.2020.12.001","journal-title":"Adv Neurotoxicol"},{"issue":"1","key":"5241_CR6","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40035-022-00279-0","volume":"11","author":"L Gao","year":"2022","unstructured":"Gao L, Zhang Y, Sterling K, Song W (2022Jan 28) Brain-derived neurotrophic factor in Alzheimer\u2019s disease and its pharmaceutical potential. Transl Neurodegener 11(1):4. https:\/\/doi.org\/10.1186\/s40035-022-00279-0","journal-title":"Transl Neurodegener"},{"issue":"18","key":"5241_CR7","doi-asserted-by":"publisher","first-page":"1518868","DOI":"10.3389\/fnmol.2025.1518868","volume":"1","author":"A Shaikh","year":"2025","unstructured":"Shaikh A, Ahmad F, Teoh SL, Kumar J, Yahaya MF (2025Apr) Neurotrophic factor alpha 1 gene therapy in Alzheimer\u2019s disease: scope and advancements. Front Mol Neurosci 1(18):1518868. https:\/\/doi.org\/10.3389\/fnmol.2025.1518868","journal-title":"Front Mol Neurosci"},{"key":"5241_CR8","doi-asserted-by":"publisher","unstructured":"Ma ZX, Liu Z, Xiong HH, Zhou ZP, Ouyang LS, Xie FK, Tang YM, Wu ZD, Feng Y (2023) MicroRNAs: protective regulators for neuron growth and development. Neural Regen Res Apr18(4):734\u2013745. https:\/\/doi.org\/10.4103\/1673-5374.353481.","DOI":"10.4103\/1673-5374.353481"},{"key":"5241_CR9","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","volume":"9","author":"J Zhang","year":"2024","unstructured":"Zhang J, Zhang Y, Wang J et al (2024) Recent advances in Alzheimer\u2019s disease: mechanisms, clinical trials and new drug development strategies. Sig Transduct Target Ther 9:211. https:\/\/doi.org\/10.1038\/s41392-024-01911-3","journal-title":"Sig Transduct Target Ther"},{"key":"5241_CR10","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3390\/antiox6040096","volume":"6","author":"C Galasso","year":"2017","unstructured":"Galasso C, Corinaldesi C, Sansone C (2017) Carotenoids from marine organisms: biological functions and industrial applications. Antioxidants 6:96","journal-title":"Antioxidants"},{"key":"5241_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105479","author":"A Donoso","year":"2021","unstructured":"Donoso A, Gonz\u00e1lez Dur\u00e1n J, Mu\u00f1oz AA, Gonz\u00e1lez PA, Agurto-Mu\u00f1oz C (2021) Therapeutic uses of natural astaxanthin: an evidence-based review focused on human clinical trials. Pharmacol Res. https:\/\/doi.org\/10.1016\/j.phrs.2021.105479","journal-title":"Pharmacol Res"},{"issue":"2","key":"5241_CR12","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3164\/jcbn.D-11-00017","volume":"51","author":"M Katagiri","year":"2012","unstructured":"Katagiri M, Satoh A, Tsuji S, Shirasawa T (2012) Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study. J Clin Biochem Nutr 51(2):102\u2013107","journal-title":"J Clin Biochem Nutr"},{"key":"5241_CR13","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1021\/acs.jmedchem.1c01144","volume":"65","author":"Z Jafari","year":"2022","unstructured":"Jafari Z, Bigham A, Sadeghi S, Dehdashti SM, Rabiee N, Abedivash A et al (2022) Nanotechnology-abetted astaxanthin formulations in multimodel therapeutic and biomedical applications. J Med Chem 65:2\u201336","journal-title":"J Med Chem"},{"issue":"11","key":"5241_CR14","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3390\/md17110628","volume":"17","author":"T Taksima","year":"2019","unstructured":"Taksima T, Chonpathompikunlert P, Sroyraya M, Hutamekalin P, Limpawattana M, Klaypradit W (2019) Effects of astaxanthin from shrimp shell on oxidative stress and behavior in animal model of Alzheimer\u2019s disease. Mar Drugs 17(11):628. https:\/\/doi.org\/10.3390\/md17110628","journal-title":"Mar Drugs"},{"key":"5241_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s43094-020-00145-8","volume":"6","author":"S Nangare","year":"2020","unstructured":"Nangare S, Dugam S (2020) Smart invasome synthesis, characterizations, pharmaceutical applications, and pharmacokinetic perspective: a review. Futur J Pharm Sci 6:1\u201321. https:\/\/doi.org\/10.1186\/s43094-020-00145-8","journal-title":"Futur J Pharm Sci"},{"issue":"3","key":"5241_CR16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1089\/adt.2024.080","volume":"23","author":"D Kumar","year":"2025","unstructured":"Kumar D, Sil D, Kurmi BD, Kumar M (2025Apr) Future prospects and regulatory pathways for invasome technologies in transdermal drug delivery. Assay Drug Dev Technol 23(3):115\u2013135. https:\/\/doi.org\/10.1089\/adt.2024.080. (Epub 2025 Jan 8 PMID: 39772638)","journal-title":"Assay Drug Dev Technol"},{"issue":"2","key":"5241_CR17","doi-asserted-by":"publisher","first-page":"p126","DOI":"10.3390\/ph15020126","volume":"15","author":"HF Salem","year":"2022","unstructured":"Salem HF et al (2022) Enhancing the bioavailability and efficacy of vismodegib for the control of skin cancer: in vitro and in vivo studies. Pharmaceuticals 15(2):p126","journal-title":"Pharmaceuticals"},{"issue":"11","key":"5241_CR18","doi-asserted-by":"publisher","first-page":"p1306","DOI":"10.3390\/ph15111306","volume":"15","author":"FIA El Ela","year":"2022","unstructured":"El Ela FIA et al (2022) In vitro and in vivo evaluation of the effectiveness and safety of amygdalin as a cancer therapy. Pharmaceuticals 15(11):p1306","journal-title":"Pharmaceuticals"},{"issue":"10","key":"5241_CR19","doi-asserted-by":"publisher","first-page":"p1633","DOI":"10.3390\/pharmaceutics13101633","volume":"13","author":"HF Salem","year":"2021","unstructured":"Salem HF et al (2021) The impact of improving dermal permeation on the efficacy and targeting of liposome nanoparticles as a potential treatment for breast cancer. Pharmaceutics 13(10):p1633","journal-title":"Pharmaceutics"},{"key":"5241_CR20","doi-asserted-by":"crossref","unstructured":"Tulbah AS, Gamal A (2021) Design and characterization of atorvastatin dry powder formulation as a potential lung cancer treatment. Saudi Pharm J\u00a0","DOI":"10.1016\/j.jsps.2021.11.002"},{"issue":"2","key":"5241_CR21","doi-asserted-by":"publisher","first-page":"p126","DOI":"10.1080\/08982104.2019.1601213","volume":"30","author":"HF Salem","year":"2020","unstructured":"Salem HF et al (2020) Treatment of breast cancer with engineered novel pH-sensitive triaryl-(Z)-olefin niosomes containing hydrogel: an in vitro and in vivo study. J Liposome Res 30(2):p126-135","journal-title":"J Liposome Res"},{"issue":"6","key":"5241_CR22","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1080\/1028415X.2016.1144846","volume":"20","author":"A Justin Thenmozhi","year":"2017","unstructured":"Justin Thenmozhi A, William Raja TR, Manivasagam T, Janakiraman U, Essa MM (2017) Hesperidin ameliorates cognitive dysfunction, oxidative stress and apoptosis against aluminium chloride induced rat model of Alzheimer\u2019s disease. Nutr Neurosci 20(6):360\u2013368","journal-title":"Nutr Neurosci"},{"key":"5241_CR23","unstructured":"Jalali MR, Roghani M (2009) The effect of nigella sativa on learning and memory in male diabetic rats. Basic and Clin Neurosci vol 1 (no 1):pp:32\u201334."},{"key":"5241_CR24","unstructured":"Rasoolijazi H, Joghataie MT, Roghani M, Nobakht M (2007) The beneficial effect of (-)-epigallocatechin-3-gallate in an experimental model of alzheimer\u2019s disease in rat. A behavioral analysis IBJ vol 114:pp:237\u2013243."},{"key":"5241_CR25","doi-asserted-by":"crossref","unstructured":"Bevins RA and Besheer J (2006) Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study recognition memory. Nature Protocols vol 1(no 3): pp:11306\u201311311","DOI":"10.1038\/nprot.2006.205"},{"key":"5241_CR26","doi-asserted-by":"crossref","unstructured":"Leger M, Quiedeville A, Bouet V et al (2013) Object recognition test in mice. Nature Protocols vol 8(no 12): pp:2531\u20132537.","DOI":"10.1038\/nprot.2013.155"},{"key":"5241_CR27","doi-asserted-by":"crossref","unstructured":"Lim S, Moon M, Oh H, Kim HG, Kim SY, Oh MS (2014) Ginger improves cognitive function via NGF-induced ERK\/ CREB activation in the hippocampus of the mouse. The J Nutr Biochem vol 25 (no 10): pp:1058\u20131065.","DOI":"10.1016\/j.jnutbio.2014.05.009"},{"key":"5241_CR28","first-page":"882","volume":"61","author":"E Beutler","year":"1963","unstructured":"Beutler E, Kelly BMDO (1963) Improved method for the determination of blood glutathione. The J Lab Clinl Med 61:882\u2013888","journal-title":"The J Lab Clinl Med"},{"key":"5241_CR29","doi-asserted-by":"crossref","unstructured":"Satoh K (1978) Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clinica Chimica Acta Int J Clin Chem vol 90: pp:37\u201343.","DOI":"10.1016\/0009-8981(78)90081-5"},{"key":"5241_CR30","doi-asserted-by":"crossref","unstructured":"Aebi H (1984) Catalase in vitro. Methods in Enzymology vol 105: pp:121\u2013126.","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"5241_CR31","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1006\/abio.1976.9999","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254. https:\/\/doi.org\/10.1006\/abio.1976.9999","journal-title":"Anal Biochem"},{"key":"5241_CR32","doi-asserted-by":"publisher","first-page":"153208","DOI":"10.1016\/j.tox.2022.153208","volume":"473","author":"PA Noshy","year":"2022","unstructured":"Noshy PA, Khalaf AAA, Ibrahim MA, Mekkawy AM, Abdelrahman RE, Farghali A, Tammam AA, Zaki AR (2022) Alterations in reproductive parameters and steroid biosynthesis induced by nickel oxide nanoparticles in male rats: the ameliorative effect of hesperidin. Toxicology 473:153208","journal-title":"Toxicology"},{"issue":"9","key":"5241_CR33","first-page":"1315","volume":"30","author":"S Mehanna","year":"2022","unstructured":"Mehanna S, Issa MY, Hassan NH, Hussien AM, Ibrahim MA, Hassanen EI (2022) Origanum majorana essential oil improves the rat\u2019s sexual behavior and testicular oxidative damage induced by imidacloprid via modulating the steroidogenesis pathways. Saudi pharmaceutical journal SPJ the official publication of the Saudi Pharmaceutical Society 30(9):1315\u20131326","journal-title":"Saudi pharmaceutical journal SPJ the official publication of the Saudi Pharmaceutical Society"},{"issue":"27","key":"5241_CR34","doi-asserted-by":"publisher","first-page":"41140","DOI":"10.1007\/s11356-021-18322-4","volume":"29","author":"Y Moustafah","year":"2022","unstructured":"Moustafah Y, Mohammed FF, Elmosalamy S, Ibrahim MA, Tohamy A, Hassan NRA (2022) Dysregulation of NrF2 expression mediates testicular injury and infertility in 3-monochloro-1,2-propandiol-intoxicated rats with special reference to accessory gland-related pathology. Environ Sci Pollut Res Int 29(27):41140\u201341150","journal-title":"Environ Sci Pollut Res Int"},{"key":"5241_CR35","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"5241_CR36","unstructured":"Suvarna SK, Layton C, Bancroft JD (2019) Bancroft\u2019s theory and practice of histological techniques. Elsevier health sciences (ISBN, 978070206864)."},{"issue":"10","key":"5241_CR37","doi-asserted-by":"publisher","first-page":"244","DOI":"10.3389\/fnagi.2018.00244","volume":"13","author":"NA Singh","year":"2018","unstructured":"Singh NA, Bhardwaj V, Ravi C, Ramesh N, Mandal AKA, Khan ZA (2018Aug) EGCG nanoparticles attenuate aluminum chloride induced neurobehavioral deficits, beta amyloid and tau pathology in a rat model of Alzheimer\u2019s disease. Front Aging Neurosci 13(10):244. https:\/\/doi.org\/10.3389\/fnagi.2018.00244","journal-title":"Front Aging Neurosci"},{"key":"5241_CR38","first-page":"355","volume":"88","author":"AB Mohamed","year":"2020","unstructured":"Mohamed AB, Mohamed AZ, Aly S (2020) Effect of thymoquinone against aluminum chloride-induced Alzheimer-like model in rats: a neurophysiological and behavioral study. Med J Cairo Univ 88:355\u2013365","journal-title":"Med J Cairo Univ"},{"key":"5241_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopha.2017.09.114","volume":"96","author":"W Huang","year":"2017","unstructured":"Huang W, Cheng P, Yu K, Han Y, Song M, Li Y (2017) Hyperforin attenuates aluminum-induced A\u03b2 production and Tau phosphorylation via regulating Akt\/GSK- 3\u03b2 signaling pathway in PC12 cells. Biomed. Pharmacother 96:1\u20136. https:\/\/doi.org\/10.1016\/j.biopha.2017.09.114","journal-title":"Biomed. Pharmacother"},{"key":"5241_CR40","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1093\/oxfordjournals.jbchem.a021914","volume":"123","author":"S Oshiro","year":"1998","unstructured":"Oshiro S, Kawahara M, Mika S, Muramoto K, Kobayashi K, Ishige R et al (1998) Aluminum taken up by transferrin-independent iron uptake affects the iron metabolism in rat cortical cells. J Biochem 123:42\u201346. https:\/\/doi.org\/10.1093\/oxfordjournals.jbchem.a021914","journal-title":"J Biochem"},{"issue":"8","key":"5241_CR41","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1055\/a-2381-6882","volume":"74","author":"K Mousavi-Nasab","year":"2024","unstructured":"Mousavi-Nasab K, Amani M, Mostafalou S (2024Oct) The effect of trientine on AlCl3-induced cognitive dysfunction and biochemical changes in the hippocampus of rats. Drug Res (Stuttg) 74(8):405\u2013414. https:\/\/doi.org\/10.1055\/a-2381-6882","journal-title":"Drug Res (Stuttg)"},{"issue":"6","key":"5241_CR42","doi-asserted-by":"publisher","first-page":"6976","DOI":"10.1021\/acsomega.3c08791","volume":"9","author":"I Kazmi","year":"2024","unstructured":"Kazmi I, Afzal M, Imam F, Alzarea SI, Patil S, Mhaiskar A, Shah U, Almalki WH (2024Jan 29) Barbaloin\u2019s chemical intervention in aluminum chloride induced cognitive deficits and changes in rats through modulation of oxidative stress, cytokines, and BDNF expression. ACS Omega 9(6):6976\u20136985. https:\/\/doi.org\/10.1021\/acsomega.3c08791","journal-title":"ACS Omega"},{"key":"5241_CR43","doi-asserted-by":"publisher","first-page":"262","DOI":"10.2741\/s514","volume":"10","author":"MA Rather","year":"2018","unstructured":"Rather MA, Thenmozhi AJ, Manivasagam T, Bharathi MD, Essa MM, Guillemin GJ (2018) Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer\u2019s disease. Fronti Biosci (Scholar edition) 10:262\u2013275. https:\/\/doi.org\/10.2741\/s514","journal-title":"Fronti Biosci (Scholar edition)"},{"issue":"14","key":"5241_CR44","first-page":"1777","volume":"5","author":"P Zatta","year":"1994","unstructured":"Zatta P, Zambenedetti P, Bruna V, Filippi B (1994) Activation of acetylcholinesterase by aluminium (III): the relevance of the metal species. Neuro Report 5(14):1777\u20131780","journal-title":"Neuro Report"},{"issue":"251","key":"5241_CR45","doi-asserted-by":"publisher","first-page":"126158","DOI":"10.1016\/j.ijbiomac.2023.126158","volume":"1","author":"Y Lv","year":"2023","unstructured":"Lv Y, Zheng Z, Liu R, Guo J, Zhang C, Xie Y (2023Nov) Monoamine oxidase B inhibitors based on natural privileged scaffolds: a review of systematically structural modification. Int J Biol Macromol 1(251):126158. https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.126158","journal-title":"Int J Biol Macromol"},{"key":"5241_CR46","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.biopha.2018.11.043","volume":"110","author":"SO Rahman","year":"2019","unstructured":"Rahman SO, Panda BP, Parvez S et al (2019) Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by A\u03b2 peptides in animal model of Alzheimer\u2019s disease. Biomed Pharmacother 110:47\u201358. https:\/\/doi.org\/10.1016\/j.biopha.2018.11.043","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"5241_CR47","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3390\/md20040247","volume":"20","author":"X Wang","year":"2022","unstructured":"Wang X, Zhang T, Chen X, Xu Y, Li Z, Yang Y et al (2022) Simultaneous inhibitory effects of all-trans astaxanthin on acetylcholinesterase and oxidative stress. Mar Drugs 20(4):247","journal-title":"Mar Drugs"},{"issue":"15","key":"5241_CR48","doi-asserted-by":"publisher","first-page":"25552","DOI":"10.18632\/oncotarget.16069","volume":"8","author":"X Jiang","year":"2017","unstructured":"Jiang X, Zhu K, Xu Q, Wang G, Zhang J, Cao R, Ye J, Yu X (2017Apr 11) The antidepressant-like effect of trans-astaxanthin involves the serotonergic system. Oncotarget 8(15):25552\u201325563. https:\/\/doi.org\/10.18632\/oncotarget.16069","journal-title":"Oncotarget"},{"issue":"1","key":"5241_CR49","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1007\/s12035-014-9053-6","volume":"53","author":"PK Kamat","year":"2016","unstructured":"Kamat PK, Kalani A, Rai S et al (2016) Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of Alzheimer\u2019s disease: understanding the therapeutics strategies. Mol Neurobiol 53(1):648\u2013661. https:\/\/doi.org\/10.1007\/s12035-014-9053-6","journal-title":"Mol Neurobiol"},{"issue":"12","key":"5241_CR50","doi-asserted-by":"publisher","first-page":"24438","DOI":"10.3390\/ijms141224438","volume":"14","author":"J Li","year":"2013","unstructured":"Li J, Wuliji O, Li W, Jiang ZG, Ghanbari HA (2013) Oxidative stress and neurodegenerative disorders. Int J Mol Sci 14(12):24438\u201324475. https:\/\/doi.org\/10.3390\/ijms141224438","journal-title":"Int J Mol Sci"},{"issue":"13","key":"5241_CR51","doi-asserted-by":"publisher","first-page":"101812","DOI":"10.1016\/j.toxrep.2024.101812","volume":"13","author":"GE Anyanwu","year":"2024","unstructured":"Anyanwu GE, Nwachukwu IJ, Oria SR, Obasi KK, Ekwueme EP, Nto JN, Anyanwu NC (2024Nov) Fisetin attenuates AlCl3-induced neurodegeneration by modulating oxidative stress and inflammatory cytokine release in adult albino wistar rats. Toxicol Rep 13(13):101812. https:\/\/doi.org\/10.1016\/j.toxrep.2024.101812","journal-title":"Toxicol Rep"},{"issue":"7","key":"5241_CR52","doi-asserted-by":"publisher","first-page":"100226","DOI":"10.1016\/j.cccb.2024.100226","volume":"20","author":"NP Utomo","year":"2024","unstructured":"Utomo NP, Pinzon RT, Latumahina PK, Damayanti KRS (2024Jun) Astaxanthin and improvement of dementia: a systematic review of current clinical trials. Cereb Circ Cogn Behav 20(7):100226. https:\/\/doi.org\/10.1016\/j.cccb.2024.100226","journal-title":"Cereb Circ Cogn Behav"},{"key":"5241_CR53","doi-asserted-by":"publisher","unstructured":"Ding X, Zhu C, Wang W, Li M, Ma C, Gao B (2024) SIRT1 is a regulator of autophagy: implications for the progression and treatment of myocardial ischemia-reperfusion. Pharmacol Res Jan 199:106957. https:\/\/doi.org\/10.1016\/j.phrs.2023.106957.","DOI":"10.1016\/j.phrs.2023.106957"},{"issue":"29","key":"5241_CR54","doi-asserted-by":"publisher","first-page":"9695","DOI":"10.1523\/JNEUROSCI.0027-10.2010","volume":"30","author":"S Mich\u00e1n","year":"2010","unstructured":"Mich\u00e1n S, Li Y, Chou MM, Parrella E, Ge H, Long JM et al (2010Jul 21) SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci 30(29):9695\u20139707. https:\/\/doi.org\/10.1523\/JNEUROSCI.0027-10.2010","journal-title":"J Neurosci"},{"issue":"1","key":"5241_CR55","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/antiox14010070","volume":"14","author":"G Guan","year":"2025","unstructured":"Guan G, Chen Y, Dong Y (2025) Unraveling the AMPK-SIRT1-FOXO pathway: the in-depth analysis and breakthrough prospects of oxidative stress-induced Diseases. Antioxidants 14(1):70. https:\/\/doi.org\/10.3390\/antiox14010070","journal-title":"Antioxidants"},{"issue":"2022","key":"5241_CR56","doi-asserted-by":"publisher","first-page":"1949718","DOI":"10.1155\/2022\/1949718.PMID:36105479;PMCID:PMC9467755","volume":"5","author":"C Fang","year":"2022","unstructured":"Fang C, Xu H, Yuan L, Zhu Z, Wang X, Liu Y, Zhang A, Shao A, Lou M (2022Sep) Natural compounds for SIRT1-Mediated oxidative stress and neuroinflammation in stroke: a potential therapeutic target in the future. Oxid Med Cell Longev 5(2022):1949718. https:\/\/doi.org\/10.1155\/2022\/1949718.PMID:36105479;PMCID:PMC9467755","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"5241_CR57","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1111\/bph.15346","volume":"178","author":"XS Zhang","year":"2021","unstructured":"Zhang XS et al (2021) Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1\/NRF2\/Prx2\/ASK1\/p38 after traumatic brain injury in mice. Br J Pharmacol 178(5):1114\u20131132","journal-title":"Br J Pharmacol"},{"key":"5241_CR58","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1007\/s11357-012-9489-4","volume":"35","author":"D Porquet","year":"2013","unstructured":"Porquet D, Casades\u00fas G, Bayod S et al (2013) Dietary resveratrol prevents Alzheimer\u2019s markers and increases life span in SAMP8. Age 35:1851\u20131865. https:\/\/doi.org\/10.1007\/s11357-012-9489-4","journal-title":"Age"},{"issue":"1","key":"5241_CR59","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s12031-025-02324-9","volume":"75","author":"DA AlHayani","year":"2025","unstructured":"AlHayani DA et al (2025) Insights into the therapeutic potential of SIRT1-modifying compounds for Alzheimer\u2019s disease: a focus on molecular mechanisms. J Mol Neurosci 75(1):29","journal-title":"J Mol Neurosci"},{"key":"5241_CR60","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nm.2559","volume":"18","author":"H Jeong","year":"2011","unstructured":"Jeong H, Cohen DE, Cui L et al (2011) Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nat Med 18:159\u2013165. https:\/\/doi.org\/10.1038\/nm.2559","journal-title":"Nat Med"},{"issue":"2","key":"5241_CR61","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.expneurol.2009.09.011","volume":"223","author":"F Hernandez","year":"2010","unstructured":"Hernandez F, Gomez de Barreda E, Fuster-Matanzo A, Lucas JJ, Avila J (2010) GSK3: a possible link between beta amyloid peptide and tau protein. Exp Neurol 223(2):322\u2013325. https:\/\/doi.org\/10.1016\/j.expneurol.2009.09.011","journal-title":"Exp Neurol"},{"key":"5241_CR62","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ejmech.2015.10.018","volume":"107","author":"M Maqbool","year":"2016","unstructured":"Maqbool M, Mobashir M, Hoda N (2016) Pivotal role of glycogen synthase kinase-3: a therapeutic target for Alzheimer\u2019s disease. Eur J Med Chem 107:63\u201381. https:\/\/doi.org\/10.1016\/j.ejmech.2015.10.018","journal-title":"Eur J Med Chem"},{"issue":"1","key":"5241_CR63","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1172\/JCI64516","volume":"123","author":"PT Ly","year":"2013","unstructured":"Ly PT, Wu Y, Zou H, Wang R, Zhou W, Kinoshita A et al (2013) Inhibition of GSK3\u03b2-mediated BACE1 expression reduces Alzheimer-associated phenotypes. J Clin Invest 123(1):224\u2013235. https:\/\/doi.org\/10.1172\/JCI64516","journal-title":"J Clin Invest"},{"issue":"7","key":"5241_CR64","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1080\/00207454.2016.1212854","volume":"127","author":"T Shabab","year":"2016","unstructured":"Shabab T, Khanabdali R, Moghadamtousi SZ, Kadir HA, Mohan G (2016) Neuroinflammation pathways: a general review. Int J Neurosci 127(7):624\u2013633","journal-title":"Int J Neurosci"},{"issue":"7","key":"5241_CR65","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1038\/mp.2016.214","volume":"22","author":"J Chu","year":"2017","unstructured":"Chu J, Lauretti E, Pratico D (2017) Caspase-3-dependent cleavage of Akt modulates tau phosphorylation via GSK3\u03b2 kinase: implications for Alzheimer\u2019s disease. Mol Psychiatry 22(7):1002\u20131008. https:\/\/doi.org\/10.1038\/mp.2016.214","journal-title":"Mol Psychiatry"},{"key":"5241_CR66","doi-asserted-by":"publisher","first-page":"5750","DOI":"10.3390\/md13095750","volume":"13","author":"H Wu","year":"2015","unstructured":"Wu H, Niu H, Shao A, Wu C, Dixon BJ, Zhang J, Yang S, Wang Y (2015) Astaxanthin as a potential neuroprotective agent for neurological diseases. Mar Drugs 13:5750\u20135766. https:\/\/doi.org\/10.3390\/md13095750","journal-title":"Mar Drugs"},{"key":"5241_CR67","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b00988","author":"H Che","year":"2018","unstructured":"Che H, Li Q, Zhang T, Wang D, Yang L, Xu J, Yanagita T, Xue C, Chang Y, Wang Y (2018) The effects of astaxanthin and docosahexaenoic acid-acylated astaxanthin on Alzheimer\u2019s disease in APP\/PS1 double transgenic mice. J Agric Food Chem. https:\/\/doi.org\/10.1021\/acs.jafc.8b00988","journal-title":"J Agric Food Chem"},{"key":"5241_CR68","doi-asserted-by":"publisher","unstructured":"Magadmi R,\u00a0Nassibi S,\u00a0Kamel F,\u00a0Al-Rafiah AR,\u00a0Bakhshwin D,\u00a0Jamal M,\u00a0Alsieni M,\u00a0Burzangi AS,\u00a0Zaher MAF,\u00a0Bendary M (2024) The protective effect of Astaxanthin on scopolamine - induced Alzheimer\u2019s model in mice. Neurosci J April 29(2):\u00a0103\u2013112. https:\/\/doi.org\/10.17712\/nsj.2024.2.20230060.","DOI":"10.17712\/nsj.2024.2.20230060"},{"issue":"5","key":"5241_CR69","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1007\/s11010-021-04079-4","volume":"476","author":"HA Hafez","year":"2021","unstructured":"Hafez HA, Kamel MA, Osman MY, Osman HM, Elblehi SS, Mahmoud SA (2021) Ameliorative effects of astaxanthin on brain tissues of Alzheimer\u2019s disease-like model: cross talk between neuronal-specific microRNA-124 and related pathways. Mol Cell Biochem 476(5):2233\u20132249. https:\/\/doi.org\/10.1007\/s11010-021-04079-4","journal-title":"Mol Cell Biochem"},{"key":"5241_CR70","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/nature09271","volume":"466","author":"J Gao","year":"2010","unstructured":"Gao J, Wang WY, Mao YW et al (2010) A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature 466:1105\u20131109. https:\/\/doi.org\/10.1038\/nature09271","journal-title":"Nature"},{"key":"5241_CR71","doi-asserted-by":"publisher","first-page":"7121827","DOI":"10.1155\/2017\/7121827","volume":"2017","author":"Y Cao","year":"2017","unstructured":"Cao Y, Yan Z, Zhou T, Wang G (2017) SIRT1 regulates cognitive performance and ability of learning and memory in diabetic and nondiabetic models. J Diabetes Res 2017:7121827. https:\/\/doi.org\/10.1155\/2017\/7121827","journal-title":"J Diabetes Res"},{"issue":"1","key":"5241_CR72","doi-asserted-by":"publisher","first-page":"e13046","DOI":"10.1111\/acel.13046","volume":"19","author":"N Baby","year":"2019","unstructured":"Baby N et al (2019) MicroRNA-134-5p inhibition rescues long-term plasticity and synaptic tagging\/capture in an A\u03b2 (1\u201342) -induced model of Alzheimer\u2019s disease. Aging Cell 19(1):e13046","journal-title":"Aging Cell"},{"issue":"1","key":"5241_CR73","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1039\/c3fo60400d","volume":"5","author":"W Wu","year":"2014","unstructured":"Wu W, Wang X, Xiang Q, Meng X, Peng Y, Du N, Liu Z, Sun Q, Wang C, Liu X (2014) Astaxanthin alleviates brain aging in rats by attenuating oxidative stress and increasing BDNF levels. Food Funct 5(1):158\u2013166. https:\/\/doi.org\/10.1039\/c3fo60400d","journal-title":"Food Funct"},{"key":"5241_CR74","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3389\/fnins.2019.00303","volume":"13","author":"E Gyengesi","year":"2019","unstructured":"Gyengesi E, Rangel A, Ullah F, Liang H, Niedermayer G, Asgarov R, Venigalla M, Gunawardena D, Karl T, M\u00fcnch G (2019) Chronic microglial activation in the GFAP-IL6 mouse contributes to age-dependent cerebellar volume loss and impairment in motor function. Front Neurosci 13:303. https:\/\/doi.org\/10.3389\/fnins.2019.00303","journal-title":"Front Neurosci"},{"issue":"11","key":"5241_CR75","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.1093\/brain\/awab223","volume":"144","author":"JB Pereira","year":"2021","unstructured":"Pereira JB, Janelidze S, Smith R et al (2021) Plasma GFAP is an early marker of amyloid-\u03b2 but not tau pathology in Alzheimer\u2019s disease. Brain 144(11):3505\u20133516","journal-title":"Brain"},{"key":"5241_CR76","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/1742-2094-9-259","volume":"9","author":"S Cao","year":"2012","unstructured":"Cao S, Standaert DG, Harms AS (2012) The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia. J Neuroinflamm 9:259","journal-title":"J Neuroinflamm"},{"key":"5241_CR77","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1742-2094-8-9","volume":"8","author":"MM Pabon","year":"2011","unstructured":"Pabon MM, Bachstetter AD, Hudson CE, Gemma C, Bickford PC (2011) CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson\u2019s disease. J Neuroinflammation 8:9","journal-title":"J Neuroinflammation"},{"key":"5241_CR78","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nn1715","volume":"9","author":"AE Cardona","year":"2006","unstructured":"Cardona AE, Pioro EP, Sasse ME, Kostenko V, Cardona SM, Dijkstra IM, Huang D, Kidd G, Dombrowski S, Dutta R et al (2006) Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci 9:917\u2013924","journal-title":"Nat Neurosci"},{"key":"5241_CR79","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3389\/fncel.2018.00323","volume":"12","author":"Z Szepesi","year":"2018","unstructured":"Szepesi Z, Manouchehrian O, Bachiller S, Deierborg T (2018) Bidirectional microglia\u2013neuron communication in health and disease. Front Cell Neurosci 12:323","journal-title":"Front Cell Neurosci"},{"key":"5241_CR80","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1084\/jem.20182238","volume":"216","author":"Q Fan","year":"2019","unstructured":"Fan Q, Gayen M, Singh N, Gao F, He W, Hu X, Tsai LH, Yan R (2019) The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer\u2019s amyloid pathology. J Exp Med 216:1891\u20131903","journal-title":"J Exp Med"},{"issue":"1","key":"5241_CR81","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.4110\/in.2018.18.e5","volume":"18","author":"M Lee","year":"2018","unstructured":"Lee M, Lee Y, Song J, Lee J, Chang SY (2018) Tissue-specific role of CX(3)CR1 expressing immune cells and their relationships with human disease. Immune Netw 18(1):e5","journal-title":"Immune Netw"},{"issue":"1","key":"5241_CR82","doi-asserted-by":"publisher","first-page":"20199","DOI":"10.1038\/s41598-025-06263-8","volume":"15","author":"NMEA El-Nasr","year":"2025","unstructured":"El-Nasr NMEA, Hussien YA, El-Baset MA, Shabana ME, Saleh DO (2025Jun 20) Astaxanthin mitigates diabetic cardiomyopathy and nephropathyin HF\/HFr\/STZ diabetic rats via modulating NOX4, fractalkine, Nrf2, and AP-1 pathways. Sci Rep 15(1):20199. https:\/\/doi.org\/10.1038\/s41598-025-06263-8","journal-title":"Sci Rep"},{"issue":"1657","key":"5241_CR83","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.brainres.2016.12.018","volume":"15","author":"XY Zhou","year":"2017","unstructured":"Zhou XY, Zhang F, Hu XT, Chen J, Tang RX, Zheng KY, Song YJ (2017Feb) Depression can be prevented by astaxanthin through inhibition of hippocampal inflammation in diabetic mice. Brain Res 15(1657):262\u2013268. https:\/\/doi.org\/10.1016\/j.brainres.2016.12.018. (Epub 2016 Dec 22 PMID: 28017669)","journal-title":"Brain Res"},{"issue":"11","key":"5241_CR84","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.1007\/s00210-023-02512-7","volume":"396","author":"F Abbaszadeh","year":"2023","unstructured":"Abbaszadeh F, Jorjani M, Joghataei MT, Raminfard S, Mehrabi S (2023Nov) Astaxanthin ameliorates spinal cord edema and astrocyte activation via suppression of HMGB1\/TLR4\/NF-\u03baB signaling pathway in a rat model of spinal cord injury. Naunyn Schmiedebergs Arch Pharmacol 396(11):3075\u20133086. https:\/\/doi.org\/10.1007\/s00210-023-02512-7","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"5241_CR85","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrm3722","volume":"15","author":"PE Czabotar","year":"2014","unstructured":"Czabotar PE, Lessene G, Strasser A, Adams JM (2014) Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol 15(1):49\u201363. https:\/\/doi.org\/10.1038\/nrm3722","journal-title":"Nat Rev Mol Cell Biol"},{"key":"5241_CR86","doi-asserted-by":"publisher","first-page":"585821","DOI":"10.3389\/fphar.2020.585821","volume":"11","author":"R Manjula","year":"2020","unstructured":"Manjula R, Anuja K, Alcain FJ (2020) SIRT1 and SIRT2 activity control in neurodegenerative diseases. Front Pharm 11:585821","journal-title":"Front Pharm"},{"key":"5241_CR87","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.3390\/md13042105","volume":"13","author":"SX Guo","year":"2015","unstructured":"Guo SX, Zhou HL, Huang CL, You CG, Fang Q, Wu P, Wang XG, Han CM (2015) Astaxanthin attenuates early acute kidney injury following severe burns in rats by ameliorating oxidative stress and mitochondrial-related apoptosis. Mar Drugs 13:2105\u20132123","journal-title":"Mar Drugs"},{"key":"5241_CR88","doi-asserted-by":"publisher","first-page":"e0187810","DOI":"10.1371\/journal.pone.0187810","volume":"12","author":"S Li","year":"2017","unstructured":"Li S, Takahara T, Fujino M, Fukuhara Y, Sugiyama T, Li XK, Takahara S (2017) Astaxanthin prevents ischemia-reperfusion injury of the steatotic liver in mice. PLoS ONE 12:e0187810","journal-title":"PLoS ONE"},{"issue":"1","key":"5241_CR89","doi-asserted-by":"publisher","first-page":"e0227631","DOI":"10.1371\/journal.pone.0227631","volume":"15","author":"S Haider","year":"2020","unstructured":"Haider S, Liaquat L, Ahmad S, Batool Z, Siddiqui RA, Tabassum S, Shahzad S, Rafiq S, Naz N (2020) Naringenin protects AlCl3\/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress. PLoS ONE 15(1):e0227631","journal-title":"PLoS ONE"},{"issue":"1","key":"5241_CR90","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3109\/01480545.2014.900068","volume":"38","author":"T Sumathi","year":"2015","unstructured":"Sumathi T, Shobana C, Thangarajeswari M, Usha R (2015) Protective effect of L-theanine against aluminium induced neurotoxicity in cerebral cortex, hippocampus and cerebellum of rat brain\u2013histopathological, and biochemical approach. Drug Chem Toxicol 38(1):22\u201331","journal-title":"Drug Chem Toxicol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05241-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-05241-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05241-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T13:14:31Z","timestamp":1761570871000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-05241-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":90,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["5241"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-05241-5","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]},"assertion":[{"value":"14 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Animal Care and Use Committee at Beni-Suef University authorized all experimental procedures, which were carried out rigorously in compliance with the rules governing the handling and care of lab animals. The procedures were approved under approval number 024\u2013017.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"All authors agree about this study publishing.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}