{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:59:26Z","timestamp":1792709966690,"version":"4.5.0"},"reference-count":115,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-025-05333-2","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:47:53Z","timestamp":1765010873000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bornyl Acetate and Menthol Provide Neuroprotection Against Lipopolysaccharide-Induced Alzheimer\u2019s Disease-Like Condition in C57BL\/6 Mice by Downregulating NARC-1 Lipid Antagonist"],"prefix":"10.1007","volume":"63","author":[{"given":"Mahalakshmi","family":"Krishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manikandan","family":"Kumaresan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeetha","family":"Ravi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livya Catherene","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beulaja","family":"Manikandan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiagarajan","family":"Raman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manikandan","family":"Ramar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,6]]},"reference":[{"issue":"1","key":"5333_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1172\/JCI200317522","volume":"111","author":"S Przedborski","year":"2003","unstructured":"Przedborski S, Vila M, Jackson-Lewis V (2003) Series introduction: neurodegeneration: what is it and where are we? J Clin Invest 111(1):3\u201310","journal-title":"J Clin Invest"},{"issue":"1","key":"5333_CR2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrn1007","volume":"4","author":"C Soto","year":"2003","unstructured":"Soto C (2003) Unfolding the role of protein misfolding in neurodegenerative diseases. Nat Rev Neurosci 4(1):49\u201360","journal-title":"Nat Rev Neurosci"},{"key":"5333_CR3","doi-asserted-by":"crossref","unstructured":"Lanctot KL, Hahn-Pedersen JH, Eichinger CS, Freeman C, Clark A, Tarazona LRS, Cummings J (2023) Burden of Illness in People with Alzheimer\u2019s Disease: A Systematic Review of Epidemiology, Comorbidities and Mortality.\u00a0J Prev Alzheimer's Dis 1\u201311.","DOI":"10.14283\/jpad.2023.61"},{"issue":"1\u20132","key":"5333_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.jns.2012.07.023","volume":"321","author":"JAS Catindig","year":"2012","unstructured":"Catindig JAS, Venketasubramanian N, Ikram MK, Chen C (2012) Epidemiology of dementia in Asia: insights on prevalence, trends and novel risk factors. J Neurol Sci 321(1\u20132):11\u201316","journal-title":"J Neurol Sci"},{"issue":"3","key":"5333_CR5","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1002\/gps.2338","volume":"25","author":"PS Mathuranath","year":"2010","unstructured":"Mathuranath PS, Cherian PJ, Mathew R, Kumar S, George A, Alexander A, Ranjith N, Sarma PS (2010) Dementia in Kerala, South India: prevalence and influence of age, education and gender. Int J Geriatr Psychiatry 25(3):290\u2013297","journal-title":"Int J Geriatr Psychiatry"},{"issue":"6","key":"5333_CR6","doi-asserted-by":"publisher","first-page":"625","DOI":"10.4103\/0028-3886.105198","volume":"60","author":"PS Mathuranath","year":"2012","unstructured":"Mathuranath PS, George A, Ranjith N, Justus S, Kumar MS, Menon R, Sarma PS, Verghese J (2012) Incidence of Alzheimer\u2019s disease in India: a 10 years follow-up study. Neurol India 60(6):625","journal-title":"Neurol India"},{"issue":"3","key":"5333_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030952","volume":"21","author":"K Ono","year":"2020","unstructured":"Ono K, Tsuji M (2020) Protofibrils of amyloid-\u03b2 are important targets of a disease-modifying approach for Alzheimer\u2019s disease. Int J Mol Sci 21(3):952","journal-title":"Int J Mol Sci"},{"issue":"6","key":"5333_CR8","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.neurobiolaging.2009.06.002","volume":"32","author":"E Portelius","year":"2011","unstructured":"Portelius E, Price E, Brinkmalm G, Stiteler M, Olsson M, Persson R, Westman- Brinkmalm A, Zetterberg H, et al. (2011) A novel pathway for amyloid precursor protein processing. Neurobiol Aging 32(6):1090\u20131098","journal-title":"Neurobiol Aging"},{"issue":"3","key":"5333_CR9","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.3233\/JAD-170581","volume":"62","author":"E Tamagno","year":"2018","unstructured":"Tamagno E, Guglielmotto M, Monteleone D, Manassero G, Vasciaveo V, Tabaton M (2018) The unexpected role of A\u03b2 1\u201342 monomers in the pathogenesis of alzheimer\u2019s disease. J Alzheimers Dis 62(3):1241\u20131245","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"5333_CR10","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1006\/bbrc.1998.9652","volume":"252","author":"YM Kuo","year":"1998","unstructured":"Kuo YM, Emmerling MR, Bisgaier CL, Essenburg AD, Lampert HC, Drumm D, Roher AE (1998) Elevated low-density lipoprotein in Alzheimer\u2019s disease correlates with brain A\u03b2 1\u201342 levels. Biochem Biophys Res Commun 252(3):711\u2013715","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"5333_CR11","doi-asserted-by":"publisher","first-page":"4050","DOI":"10.1523\/JNEUROSCI.20-11-04050.2000","volume":"20","author":"L Mucke","year":"2000","unstructured":"Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, et al. (2000) High-level neuronal expression of A\u03b21\u201342 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci 20(11):4050\u20134058","journal-title":"J Neurosci"},{"key":"5333_CR12","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.neuroscience.2015.10.006","volume":"310","author":"HF Zhao","year":"2015","unstructured":"Zhao HF, Li N, Wang Q, Cheng XJ, Li XM, Liu TT (2015) Resveratrol decreases the insoluble A\u03b21\u201342 level in hippocampus and protects the integrity of the blood\u2013brain barrier in AD rats. J Neurosci 310:641\u2013649","journal-title":"J Neurosci"},{"issue":"2","key":"5333_CR13","first-page":"83","volume":"1","author":"K Dastmalchi","year":"2007","unstructured":"Dastmalchi K, Dorman HD, Vuorela H, Hiltunen R (2007) Plants as potential sources for drug development against Alzheimer\u2019s disease. Int J Biomed Pharmaceut Sci 1(2):83\u2013104","journal-title":"Int J Biomed Pharmaceut Sci"},{"issue":"5","key":"5333_CR14","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.jalz.2011.05.2410","volume":"7","author":"CG Lyketsos","year":"2011","unstructured":"Lyketsos CG, Carrillo MC, Ryan JM, Khachaturian AS, Trzepacz P, Amatniek J, Cedarbaum J, Brashear R, et al. (2011) Neuropsychiatric symptoms in Alzheimer\u2019s disease. Alzheimer\u2019s Dement 7(5):532\u2013539","journal-title":"Alzheimer's Dement"},{"issue":"4","key":"5333_CR15","doi-asserted-by":"publisher","first-page":"581","DOI":"10.4172\/pharmaceutical-sciences.1000397","volume":"80","author":"R Sajjad","year":"2018","unstructured":"Sajjad R, Arif R, Shah AA, Manzoor I, Mustafa G (2018) Pathogenesis of Alzheimer\u2019s disease: role of amyloid-beta and hyperphosphorylated tau protein. Indian J Pharm Sci 80(4):581\u2013591","journal-title":"Indian J Pharm Sci"},{"key":"5333_CR16","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.14506.1","author":"J Weller","year":"2018","unstructured":"Weller J, Budson A (2018) Current understanding of Alzheimer\u2019s disease diagnosis and treatment. F1000Res. https:\/\/doi.org\/10.12688\/f1000research.14506.1","journal-title":"F1000Res"},{"key":"5333_CR17","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0072-9752(07)84035-8","volume":"84","author":"Y Compta","year":"2007","unstructured":"Compta Y, Tolosa E (2007) Anticholinergic medications. Handb Clin Neurol 84:121\u2013125","journal-title":"Handb Clin Neurol"},{"issue":"1","key":"5333_CR18","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3390\/pharmaceutics15010230","volume":"15","author":"M Lavrador","year":"2023","unstructured":"Lavrador M, Cabral AC, Ver\u00edssimo MT, Fernandez-Llimos F, Figueiredo IV, Castel-Branco MM (2023) A universal pharmacological-based list of drugs with anticholinergic activity. Pharmaceutics 15(1):230","journal-title":"Pharmaceutics"},{"issue":"9","key":"5333_CR19","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/S1474-4422(07)70195-3","volume":"6","author":"H Kavirajan","year":"2007","unstructured":"Kavirajan H, Schneider LS (2007) Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials. Lancet Neurol 6(9):782\u2013792","journal-title":"Lancet Neurol"},{"key":"5333_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1742-2094-5-37","volume":"5","author":"JW Lee","year":"2008","unstructured":"Lee JW, Lee YK, Yuk DY, Choi DY, Ban SB, Oh KW, Hong JT (2008) Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation. J Neuroinflammation 5:1\u201314","journal-title":"J Neuroinflammation"},{"issue":"1","key":"5333_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40035-021-00273-y","volume":"10","author":"S Kim","year":"2021","unstructured":"Kim S, Shin SJ, Park YH, Nam Y, Kim SM, Jung ID, Yang HD, Park YM, et al. (2021) Gram-negative bacteria and their lipopolysaccharides in Alzheimer\u2019s disease: pathologic roles and therapeutic implications. Transl Neurodegener 10(1):1\u201323","journal-title":"Transl Neurodegener"},{"issue":"7S_Part_19","key":"5333_CR22","doi-asserted-by":"publisher","first-page":"P944","DOI":"10.1016\/j.jalz.2017.06.1852","volume":"13","author":"G Chandran","year":"2017","unstructured":"Chandran G, Sugur K, Chauhan JB (2017) Prophylactic neuroprotective efficacy of selaginella (sanjeevani) flavonoids against lipopolysaccharide-induced neurodegeneration in drosophila and mice: relevance to Alzheimer\u2019s disease therapy. Alzheimers Dement 13(7S_Part_19):P944\u2013P945","journal-title":"Alzheimers Dement"},{"issue":"16","key":"5333_CR23","doi-asserted-by":"publisher","first-page":"6309","DOI":"10.1523\/JNEUROSCI.20-16-06309.2000","volume":"20","author":"WG Kim","year":"2000","unstructured":"Kim WG, Mohney RP, Wilson B, Jeohn GH, Liu B, Hong JS (2000) Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J Neurosci 20(16):6309\u20136316","journal-title":"J Neurosci"},{"issue":"1","key":"5333_CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-37186-2","volume":"9","author":"J Zhao","year":"2019","unstructured":"Zhao J, Bi W, Xiao S, Lan X, Cheng X, Zhang J, Lu D, Wei W, et al. (2019) Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice. Sci Rep 9(1):1\u201312","journal-title":"Sci Rep"},{"key":"5333_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154781","volume":"114","author":"ZJ Zhao","year":"2023","unstructured":"Zhao ZJ, Sun YL, Ruan XF (2023) Bornyl acetate: a promising agent in phytomedicine for inflammation and immune modulation. Phytomedicine 114:154781","journal-title":"Phytomedicine"},{"issue":"1","key":"5333_CR26","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.jss.2013.09.003","volume":"186","author":"N Chen","year":"2014","unstructured":"Chen N, Sun G, Yuan X, Hou J, Wu Q, Soromou LW, Feng H (2014) Inhibition of lung inflammatory responses by bornyl acetate is correlated with regulation of myeloperoxidase activity. J Surg Res 186(1):436\u2013445","journal-title":"J Surg Res"},{"issue":"9","key":"5333_CR27","doi-asserted-by":"publisher","first-page":"3908","DOI":"10.1016\/j.biortech.2007.07.050","volume":"99","author":"YT Tung","year":"2008","unstructured":"Tung YT, Chua MT, Wang SY, Chang ST (2008) Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs. Bioresour Technol 99(9):3908\u20133913","journal-title":"Bioresour Technol"},{"key":"5333_CR28","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s10068-015-0093-0","volume":"24","author":"BH Lee","year":"2015","unstructured":"Lee BH, Nam TG, Park WJ, Kang H, Heo HJ, Chung DK, Kim GH, Kim DO (2015) Antioxidative and neuroprotective effects of volatile components in essential oils from Chrysanthemum indicum Linn\u00e9 flowers. Food Sci Biotechnol 24:17\u2013723","journal-title":"Food Sci Biotechnol"},{"key":"5333_CR29","unstructured":"Huang L, Zhong X, Zhou Z, Wang N, Deng M (2022) Neuroprotective effects of bornyl acetate against okadaic acid\u2013Induced cytotoxicity in pc12 cells via beclin-1-dependent autophagy pathway.\u00a0Pharmacogn. Mag\u00a018(80)."},{"key":"5333_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154569","volume":"112","author":"JI Lee","year":"2022","unstructured":"Lee JI, Choi JH, Kwon TW, Jo HS, Kim DG, Ko SG, Song GJ, Cho IH (2022) Neuroprotective effects of bornyl acetate on experimental autoimmune encephalomyelitis via anti-inflammatory effects and maintaining blood-brain-barrier integrity. Phytomedicine 112:154569","journal-title":"Phytomedicine"},{"issue":"2","key":"5333_CR31","first-page":"151","volume":"32","author":"E Matsubara","year":"2011","unstructured":"Matsubara E, Fukagawa M, Okamoto T, Ohnuki K, Shimizu K, Kondo R (2011) (-)-Bornyl acetate induces autonomic relaxation and reduces arousal level after visual display terminal work without any influences of task performance in low-dose condition. Biomed Res J 32(2):151\u2013157","journal-title":"Biomed Res J"},{"issue":"3","key":"5333_CR32","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0304-3940(01)02527-7","volume":"322","author":"N Galeotti","year":"2002","unstructured":"Galeotti N, Mannelli LDC, Mazzanti G, Bartolini A, Ghelardini C (2002) Menthol: a natural analgesic compound. Neurosci Lett 322(3):145\u2013148","journal-title":"Neurosci Lett"},{"key":"5333_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106679","volume":"85","author":"J Du","year":"2020","unstructured":"Du J, Liu D, Zhang X, Zhou A, Su Y, He D, Fu Gao SF (2020) Menthol protects dopaminergic neurons against inflammation-mediated damage in lipopolysaccharide (LPS)-evoked model of Parkinson\u2019s disease. Int Immunopharmacol 85:106679","journal-title":"Int Immunopharmacol"},{"key":"5333_CR34","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.neurobiolaging.2022.02.011","volume":"113","author":"I Guisle","year":"2022","unstructured":"Guisle I, Canet G, P\u00e9try S, Fereydouni-Forouzandeh P, Morin F, K\u00e9rauden R, Whittington RA, Calon F, et al. (2022) Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia. Neurobiol Aging 113:118\u2013130","journal-title":"Neurobiol Aging"},{"issue":"12","key":"5333_CR35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114767","volume":"9","author":"Z Sun","year":"2014","unstructured":"Sun Z, Wang H, Wang J, Zhou L, Yang P (2014) Chemical composition and anti-inflammatory, cytotoxic and antioxidant activities of essential oil from leaves of Mentha piperita grown in China. PLoS ONE 9(12):e114767","journal-title":"PLoS ONE"},{"issue":"4","key":"5333_CR36","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.32604\/biocell.2021.015261","volume":"45","author":"Y Ruan","year":"2021","unstructured":"Ruan Y, Xie Z, Liu Q, Zhang L, Han X, Liao X, Liu J, Gao F (2021) Nicotine and menthol independently exert neuroprotective effects against cisplatin-or amyloid toxicity by upregulating Bcl-xl via JNK activation in SH-SY5Y cells. Biocell 45(4):1059","journal-title":"Biocell"},{"issue":"8","key":"5333_CR37","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3390\/biomedicines8080258","volume":"8","author":"J Kim","year":"2020","unstructured":"Kim J, Joshi HP, Kim KT, Kim YY, Yeo K, Choi H, Kim YW, Choi UY, et al. (2020) Combined treatment with fasudil and menthol improves functional recovery in rat spinal cord injury model. Biomedicines 8(8):258","journal-title":"Biomedicines"},{"issue":"1","key":"5333_CR38","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/s12974-022-02553-4","volume":"19","author":"SS Huang","year":"2022","unstructured":"Huang SS, Su HH, Chien SY, Chung HY, Luo ST, Chu YT, Wang YH, MacDonald IJ, et al. (2022) Activation of peripheral TRPM8 mitigates ischemic stroke by topically applied menthol. J Neuroinflammation 19(1):192","journal-title":"J Neuroinflammation"},{"key":"5333_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113559","volume":"154","author":"H Zhao","year":"2022","unstructured":"Zhao H, Ren S, Yang H, Tang S, Guo C, Liu M, Tao Q, Ming T, et al. (2022) Peppermint essential oil: its phytochemistry, biological activity, pharmacological effect and application. Biomed Pharmacother 154:113559","journal-title":"Biomed Pharmacother"},{"key":"5333_CR40","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","volume":"11","author":"R Morris","year":"1984","unstructured":"Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11:47\u201360","journal-title":"J Neurosci Methods"},{"key":"5333_CR41","doi-asserted-by":"crossref","unstructured":"Zhao J, Bi W, Xiao S, Lan X, Cheng X, Zhang J, Lu D, Wei W, Wang Y, Li H, Fu Y (2019) Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice. Sci Rep 8;9(1): 1\u20132.","DOI":"10.1038\/s41598-019-42286-8"},{"issue":"135","key":"5333_CR42","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.brainresbull.2017.09.010","volume":"1","author":"X Jiang","year":"2017","unstructured":"Jiang X, Liu J, Lin Q, Mao K, Tian F, Jing C, Wang C, Ding L, et al. (2017) Proanthocyanidin prevents lipopolysaccharide-induced depressive-like behavior in mice via neuroinflammatory pathway. Brain Res Bull 1(135):40\u201346","journal-title":"Brain Res Bull"},{"key":"5333_CR43","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jns.2006.06.018","volume":"249","author":"M Mohanasundari","year":"2006","unstructured":"Mohanasundari M, Srinivasan MS, Sethupathy S, Sabesan M (2006) Enhanced neuroprotective effect by combination of bromocriptine and Hypericum perforatum extract against MPTP-induced neurotoxicity in mice. J Neurol Sci 249:140\u2013144","journal-title":"J Neurol Sci"},{"key":"5333_CR44","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neulet.2009.02.044","volume":"454","author":"S RajaSankar","year":"2009","unstructured":"RajaSankar S, Manivasagam T, Surendran S (2009) Ashwagandha leaf extract: a potential agent in treating oxidative damage and physiological abnormalities seen in a mouse model of Parkinson\u2019s disease. Neurosci Lett 454:11\u201315","journal-title":"Neurosci Lett"},{"key":"5333_CR45","first-page":"297","volume":"8","author":"RA Ismaeil","year":"2021","unstructured":"Ismaeil RA, Hui CK, Affandi KA, Alallam B, Mohamed W, Mohd Noor MF (2021) Neuroprotective effect of edible bird\u2019s nest in chronic cerebral hypoperfusion induced neurodegeneration in rats. Neuroimmunol Neuroinflamm 8:297\u2013306","journal-title":"Neuroimmunol Neuroinflamm"},{"key":"5333_CR46","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.redox.2017.04.004","volume":"12","author":"A Garcimart\u00edn","year":"2017","unstructured":"Garcimart\u00edn A, L\u00f3pez-Oliva ME, Gonz\u00e1lez MP, S\u00e1nchez-Muniz FJ, Bened\u00ed J (2017) Hydrogen peroxide modifies both activity and isoforms of acetylcholinesterase in human neuroblastoma SH-SY5Y cells. Redox Biol 12:719\u2013726","journal-title":"Redox Biol"},{"issue":"2","key":"5333_CR47","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.jaad.2005.08.041","volume":"55","author":"ST Cheung","year":"2006","unstructured":"Cheung ST, Maheshwari MB, Tan CY (2006) A comparative study of two Congo red stains for the detection of primary cutaneous amyloidosis. J Am Acad Dermatol 55(2):363\u2013364","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"5333_CR48","doi-asserted-by":"publisher","first-page":"259","DOI":"10.4062\/biomolther.2019.123","volume":"28","author":"X Zhang","year":"2020","unstructured":"Zhang X, Wang J, Gong G, Ma R, Xu F, Yan T, Wu B, Jia Y (2020) Spinosin inhibits a\u03b21-42 production and aggregation via activating Nrf2\/HO-1 pathway. Biomol Ther 28(3):259","journal-title":"Biomol Ther"},{"issue":"3","key":"5333_CR49","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3109\/10520294809106233","volume":"23","author":"FB Adamstone","year":"1948","unstructured":"Adamstone FB, Taylor AB (1948) The rapid preparation of frozen tissue sections. Stain Technol 23(3):109\u2013116","journal-title":"Stain Technol"},{"key":"5333_CR50","doi-asserted-by":"crossref","unstructured":"Roos D, Seeger R, Puntel, Vargas Barbosa N (2012) Role of calcium and mitochondria in MeHg-mediated cytotoxicity.\u00a0J Biomed Biotechnol 2012.","DOI":"10.1155\/2012\/248764"},{"key":"5333_CR51","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot4493","volume":"3","author":"S Kasibhatla","year":"2006","unstructured":"Kasibhatla S, Amarante-Mendes GP, Finucane D, Brunner T, Bossy-Wetzel E, Green DR (2006) Acridine orange\/ethidium bromide (AO\/EB) staining to detect apoptosis. Cold Spring Harb Protoc 3:pdb-prot4493","journal-title":"Cold Spring Harb Protoc"},{"key":"5333_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117596","volume":"250","author":"AK Ghosh","year":"2020","unstructured":"Ghosh AK, Bhattacharjee B, Mishra S, Roy S, Chattopadhyay A, Banerjee A, Bandyopadhyay D (2020) Beta-estradiol protects against copper-ascorbate induced oxidative damage in goat liver mitochondria in vitro by binding with ascorbic acid. Life Sci 250:117596","journal-title":"Life Sci"},{"key":"5333_CR53","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.neures.2014.12.015","volume":"94","author":"P Youn","year":"2015","unstructured":"Youn P, Chen Y, Furgeson DY (2015) Cytoprotection against beta-amyloid (A\u03b2) peptide-mediated oxidative damage and autophagy by Keap1 RNAi in human glioma U87mg cells. Neurosci Res 94:70\u201378","journal-title":"Neurosci Res"},{"key":"5333_CR54","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.exer.2014.09.007","volume":"128","author":"MS Varsha","year":"2014","unstructured":"Varsha MS, Raman T, Manikandan R (2014) Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis. Exp Eye Res 128:73\u201382","journal-title":"Exp Eye Res"},{"issue":"5","key":"5333_CR55","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.neuint.2010.06.021","volume":"57","author":"L Zhang","year":"2010","unstructured":"Zhang L, Yu H, Zhao X, Lin X, Tan C, Cao G, Wang Z (2010) Neuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells. Neurochem Int 57(5):547\u2013555","journal-title":"Neurochem Int"},{"issue":"11","key":"5333_CR56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113682","volume":"9","author":"R Russo","year":"2014","unstructured":"Russo R, Cassiano MG, Ciociaro A, Adornetto A, Varano GP, Chiappini C, Berliocchi L, Tassorelli C, et al. (2014) Role of D-limonene in autophagy induced by bergamot essential oil in SH-SY5Y neuroblastoma cells. PLoS ONE 9(11):e113682","journal-title":"PLoS ONE"},{"issue":"1","key":"5333_CR57","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/j.1749-6632.2012.06513.x","volume":"1259","author":"P Gamba","year":"2012","unstructured":"Gamba P, Testa G, Sottero B, Gargiulo S, Poli G, Leonarduzzi G (2012) The link between altered cholesterol metabolism and Alzheimer\u2019s disease. Ann N Y Acad Sci 1259(1):54\u201364","journal-title":"Ann N Y Acad Sci"},{"key":"5333_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2021.105072","volume":"236","author":"S Garc\u00eda-Vi\u00f1uales","year":"2021","unstructured":"Garc\u00eda-Vi\u00f1uales S, Sciacca MF, Lanza V, Santoro AM, Grasso G, Tundo GR, Sbardella D, Coletta M, et al. (2021) The interplay between lipid and A\u03b2 amyloid homeostasis in Alzheimer\u2019s disease: risk factors and therapeutic opportunities. Chem Phys Lipids 236:105072","journal-title":"Chem Phys Lipids"},{"issue":"2","key":"5333_CR59","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1111\/ejn.14949","volume":"53","author":"NP Samant","year":"2021","unstructured":"Samant NP, Gupta GL (2021) Novel therapeutic strategies for Alzheimer\u2019s disease targeting brain cholesterol homeostasis. Eur J Neurosci 53(2):673\u2013686","journal-title":"Eur J Neurosci"},{"issue":"6","key":"5333_CR60","doi-asserted-by":"publisher","first-page":"5222","DOI":"10.3390\/ijms24065222","volume":"24","author":"LB Eddin","year":"2023","unstructured":"Eddin LB, Azimullah S, Jha NK, Nagoor Meeran MF, Beiram R, Ojha S (2023) Limonene, a monoterpene, mitigates rotenone-induced dopaminergic neurodegeneration by modulating neuroinflammation, Hippo signaling and apoptosis in rats. Int J Mol Sci 24(6):5222","journal-title":"Int J Mol Sci"},{"key":"5333_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1750-1326-4-48","volume":"4","author":"GM Shankar","year":"2009","unstructured":"Shankar GM, Walsh DM (2009) Alzheimer\u2019s disease: synaptic dysfunction and A\u03b2. Mol Neurodegener 4:1\u201313","journal-title":"Mol Neurodegener"},{"issue":"1\u20133","key":"5333_CR62","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.ejphar.2013.04.033","volume":"715","author":"N Rajasekar","year":"2013","unstructured":"Rajasekar N, Dwivedi S, kumar Tota S, Kamat PK, Hanif K, Nath C, Shukla R (2013) Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice. Eur J Pharmacol 715(1\u20133):381\u2013394","journal-title":"Eur J Pharmacol"},{"key":"5333_CR63","doi-asserted-by":"crossref","unstructured":"Tyagi E, Agrawal R, Nath C, Shukla R (2007) Effect of anti-dementia drugs on LPS induced neuroinflammation in mice. Life Sci 1;80(21): 1977\u201383.","DOI":"10.1016\/j.lfs.2007.02.039"},{"issue":"4","key":"5333_CR64","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1111\/j.1742-4658.2007.06238.x","volume":"275","author":"NC Inestrosa","year":"2008","unstructured":"Inestrosa NC, Dinamarca MC, Alvarez A (2008) Amyloid\u2013cholinesterase interactions: implications for Alzheimer\u2019s disease. FEBS J 275(4):625\u2013632","journal-title":"FEBS J"},{"key":"5333_CR65","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00025","author":"F Kametani","year":"2018","unstructured":"Kametani F, Hasegawa M (2018) Reconsideration of amyloid hypothesis and tau hypothesis in Alzheimer\u2019s disease. Front Neurosci. https:\/\/doi.org\/10.3389\/fnins.2018.00025","journal-title":"Front Neurosci"},{"key":"5333_CR66","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2016.00118","volume":"9","author":"WM Snow","year":"2016","unstructured":"Snow WM, Albensi BC (2016) Neuronal gene targets of NF-\u03baB and their dysregulation in Alzheimer\u2019s disease. Front Mol Neurosci 9:118","journal-title":"Front Mol Neurosci"},{"key":"5333_CR67","doi-asserted-by":"crossref","unstructured":"Simunkova M, Alwasel SH,Alhazza IM , Jomova K,Kollar V , Rusko M, ValkoM (2019) Management of oxidative stress and other pathologies in Alzheimer\u2019s disease.\u00a0Arch. Toxicol\u00a093: 2491\u20132513.","DOI":"10.1007\/s00204-019-02538-y"},{"issue":"8","key":"5333_CR68","doi-asserted-by":"publisher","first-page":"560","DOI":"10.5483\/BMBRep.2008.41.8.560","volume":"41","author":"RM Adibhatla","year":"2008","unstructured":"Adibhatla RM, Hatcher JF (2008) Phospholipase A2, reactive oxygen species, and lipid peroxidation in CNS pathologies. BMB Rep 41(8):560","journal-title":"BMB Rep"},{"key":"5333_CR69","doi-asserted-by":"crossref","unstructured":"Pocernich CB, La Fontaine M, Butterfield DA (2008) In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain. Neurochem Int 1; 36(3): 185\u201391.","DOI":"10.1016\/S0197-0186(99)00126-6"},{"key":"5333_CR70","doi-asserted-by":"crossref","unstructured":"Badshah H, Ikram M, Ali W, Ahmad S, Hahm JR, Kim MO (2019) Caffeine may abrogate LPS-induced oxidative stress and neuroinflammation by regulating Nrf2\/TLR4 in adult mouse brains. Biomolecules. 8;9(11): 719.","DOI":"10.3390\/biom9110719"},{"issue":"2","key":"5333_CR71","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3390\/molecules22020263","volume":"22","author":"C Mogosan","year":"2017","unstructured":"Mogosan C, Vostinaru O, Oprean R, Heghes C, Filip L, Balica G, Moldovan RI (2017) A comparative analysis of the chemical composition, anti-inflammatory, and antinociceptive effects of the essential oils from three species of Mentha cultivated in Romania. Molecules 22(2):263","journal-title":"Molecules"},{"key":"5333_CR72","doi-asserted-by":"crossref","unstructured":"Prasad SN, Muralidhara (2014) Protective effects of geraniol (a monoterpene) in a diabetic neuropathy rat model: attenuation of behavioral impairments and biochemical perturbations.\u00a0J Neurosci Res\u00a092(9): 1205\u20131216.","DOI":"10.1002\/jnr.23393"},{"key":"5333_CR73","doi-asserted-by":"crossref","unstructured":"Essa MA, Ela EIA, Ibrahim MAER, Ibrahim IH (2022) Cytotoxicity and genotoxicity reveal the link between acute cadmium exposure and Alzheimer\u2019s disease.","DOI":"10.21203\/rs.3.rs-2317612\/v1"},{"issue":"2","key":"5333_CR74","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.lfs.2014.06.023","volume":"110","author":"MA Ahmed","year":"2014","unstructured":"Ahmed MA, El Morsy EM, Ahmed AA (2014) Pomegranate extract protects against cerebral ischemia\/reperfusion injury and preserves brain DNA integrity in rats. Life Sci 110(2):61\u201369","journal-title":"Life Sci"},{"issue":"1","key":"5333_CR75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-022-03657-3","volume":"22","author":"T Afsar","year":"2022","unstructured":"Afsar T, Razak S, Almajwal A (2022) Reversal of cisplatin triggered neurotoxicity by Acacia hydaspica ethyl acetate fraction via regulating brain acetylcholinesterase activity, DNA damage, and pro-inflammatory cytokines in the rodent model. BMC Complement Med Ther 22(1):1\u201312","journal-title":"BMC Complement Med Ther"},{"issue":"12","key":"5333_CR76","doi-asserted-by":"publisher","first-page":"785","DOI":"10.3390\/nu8120785","volume":"8","author":"A Azqueta","year":"2016","unstructured":"Azqueta A, Collins A (2016) Polyphenols and DNA damage: a mixed blessing. Nutrients 8(12):785","journal-title":"Nutrients"},{"issue":"8","key":"5333_CR77","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1016\/j.bbadis.2013.10.015","volume":"1842","author":"X Wang","year":"2014","unstructured":"Wang X, Wang W, Li L, Perry G, Lee HG, Zhu X (2014) Oxidative stress and mitochondrial dysfunction in Alzheimer\u2019s disease. Biochimica et Biophysica Acta (BBA) 1842(8):1240\u20131247","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"issue":"2","key":"5333_CR78","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0014-4886(02)00012-2","volume":"179","author":"A Oliveira","year":"2003","unstructured":"Oliveira A, Hodges H, Rezaie P (2003) Excitotoxic lesioning of the rat basal forebrain with S-AMPA:consequent mineralization and associated glial response. Exp Neurol 179(2):127\u2013138","journal-title":"Exp Neurol"},{"issue":"5","key":"5333_CR79","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1002\/jlb.64.5.615","volume":"64","author":"V Seabra","year":"1998","unstructured":"Seabra V, Stachlewitz RF, Thurman RG (1998) Taurine blunts LPS-induced increases in intracellular calcium and TNF-\u03b1 production by Kupffer cells. J Leukoc Biol 64(5):615\u2013621","journal-title":"J Leukoc Biol"},{"issue":"2","key":"5333_CR80","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/ptr.5246","volume":"29","author":"A Sun","year":"2015","unstructured":"Sun A, Xu X, Lin J, Cui X, Xu R (2015) Neuroprotection by saponins. Phytother Res 29(2):187\u2013200","journal-title":"Phytother Res"},{"key":"5333_CR81","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/01.hjh.0000548050.10768.f4","volume":"36","author":"S Lin","year":"2018","unstructured":"Lin S, Xiong S, Zhu Z, Liu D (2018) A1954 TRPM8 activation blunts mitochondrial dysfunction-mediated inflammation in monocytes during cold-induced hypertension. J Hypertens 36:16","journal-title":"J Hypertens"},{"key":"5333_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154781","author":"ZJ Zhao","year":"2023","unstructured":"Zhao ZJ, Sun YL, Ruan XF (2023) Bornyl acetate: a promising agent in phytomedicine for inflammation and immune modulation. Phytomedicine. https:\/\/doi.org\/10.1016\/j.phymed.2023.154781","journal-title":"Phytomedicine"},{"issue":"9","key":"5333_CR83","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.2174\/1570159X19666210608165509","volume":"19","author":"NP Kulkarni","year":"2021","unstructured":"Kulkarni NP, Vaidya B, Narula AS, Sharma SS (2021) Neuroprotective potential of caffeic acid phenethyl ester (CAPE) in CNS disorders: mechanistic and therapeutic insights. Curr Neuropharmacol 19(9):1401","journal-title":"Curr Neuropharmacol"},{"key":"5333_CR84","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s10863-011-9362-7","volume":"43","author":"YD Xi","year":"2011","unstructured":"Xi YD, Yu HL, Ma WW, Ding BJ, Ding J, Yuan LH, Feng JF, Xiao R (2011) Genistein inhibits mitochondrial-targeted oxidative damage induced by beta-amyloid peptide 25\u201335 in PC12 cells. J Bioenerg Biomembr 43:399\u2013407","journal-title":"J Bioenerg Biomembr"},{"key":"5333_CR85","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X0900400819","author":"E Schmidt","year":"2009","unstructured":"Schmidt E, Bail S, Buchbauer G, Stoilova I, Atanasova T, Stoyanova A, Krastanov A, Jirovetz L (2009) Chemical composition, olfactory evaluation and antioxidant effects of essential oil from Mentha x piperita. Nat Prod Commun. https:\/\/doi.org\/10.1177\/1934578X0900400819","journal-title":"Nat Prod Commun"},{"issue":"23","key":"5333_CR86","doi-asserted-by":"publisher","first-page":"4716","DOI":"10.1021\/acs.jafc.6b00986","volume":"64","author":"R Perez-Roses","year":"2016","unstructured":"Perez-Roses R, Risco E, Vila R, Penalver P, Canigueral S (2016) Biological and nonbiological antioxidant activity of some essential oils. J Agric Food Chem 64(23):4716\u20134724","journal-title":"J Agric Food Chem"},{"issue":"10","key":"5333_CR87","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3389\/fnagi.2018.00042","volume":"22","author":"X Zhan","year":"2018","unstructured":"Zhan X, Stamova B, Sharp FR (2018) Lipopolysaccharide associates with amyloid plaques, neurons and oligodendrocytes in Alzheimer\u2019s disease brain: a review. Front Aging Neurosci 22(10):42","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"5333_CR88","first-page":"86","volume":"8","author":"LM Wang","year":"2018","unstructured":"Wang LM, Wu Q, Kirk RA, Horn KP, Salem AH, Hoffman JM, Yap JT, Sonnen JA, et al. (2018) Lipopolysaccharide endotoxemia induces amyloid-\u03b2 and p-tau formation in the rat brain. Am J Nucl Med Mol Imaging 8(2):86","journal-title":"Am J Nucl Med Mol Imaging"},{"issue":"7","key":"5333_CR89","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/j.bbapap.2010.04.001","volume":"1804","author":"M Biancalana","year":"2010","unstructured":"Biancalana M, Koide S (2010) Molecular mechanism of Thioflavin-T binding to amyloid fibrils. Biochimica et Biophysica Acta (BBA) 1804(7):1405\u20131412","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"key":"5333_CR90","doi-asserted-by":"publisher","first-page":"4263","DOI":"10.1007\/s00044-012-0414-2","volume":"22","author":"SJ Jung","year":"2013","unstructured":"Jung SJ, Park YD, Park JH, Yang SD, Hur MG, Yu KH (2013) Synthesis and evaluation of thioflavin-T analogs as potential imaging agents for amyloid plaques. Med Chem Res 22:4263\u20134268","journal-title":"Med Chem Res"},{"key":"5333_CR91","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3390\/ijms22010361","volume":"22","author":"R Ullah","year":"2020","unstructured":"Ullah R, Ikram M, Park TJ, Ahmad R, Saeed K, Alam SI, Rehman IU, Khan A, et al. (2020) Vanillic acid, a bioactive phenolic compound, counteracts LPS-induced neurotoxicity by regulating c-Jun N-terminal kinase in mouse brain. Int J Mol Sci 22:361","journal-title":"Int J Mol Sci"},{"issue":"6","key":"5333_CR92","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/ffj.3156","volume":"28","author":"R Videira","year":"2013","unstructured":"Videira R, Castanheira P, Gr\u00e3os M, Salgueiro L, Faro C, Cavaleiro C (2013) A necrodane monoterpenoid from Lavandula luisieri essential oil as a cell-permeable inhibitor of BACE-1, the \u03b2-secretase in Alzheimer\u2019s disease. Flavour Fragr J 28(6):380\u2013388","journal-title":"Flavour Fragr J"},{"issue":"3","key":"5333_CR93","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1002\/ptr.7384","volume":"36","author":"R Song","year":"2022","unstructured":"Song R, Han S, Gao H, Jiang H, Li X (2022) Crocin alleviates cognitive impairment associated with atherosclerosis via improving neuroinflammation in LDLR\u2212\/\u2212 mice fed a high-fat\/cholesterol diet. Phytother Res 36(3):1284\u20131296","journal-title":"Phytother Res"},{"key":"5333_CR94","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.biopha.2018.03.152","volume":"103","author":"L Yang","year":"2018","unstructured":"Yang L, Liu J, Li Y, Qi G (2018) Bornyl acetate suppresses ox-LDL-induced attachment of THP-1 monocytes to endothelial cells. Biomed Pharmacother 103:234\u2013239","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"5333_CR95","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155030","volume":"11","author":"E Topchiy","year":"2016","unstructured":"Topchiy E, Cirstea M, Kong HJ, Boyd JH, Wang Y, Russell JA, Walley KR (2016) Lipopolysaccharide is cleared from the circulation by hepatocytes via the low density lipoprotein receptor. PLoS ONE 11(5):e0155030","journal-title":"PLoS ONE"},{"key":"5333_CR96","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6627104","author":"K Huang","year":"2022","unstructured":"Huang K, Chen Y, Liang K, Xu X, Jiang J, Liu M, Zhou F (2022) Review of the chemical composition, pharmacological effects, pharmacokinetics, and quality control of Boswellia carterii. Evidence-Based Complementary and Alternative Medicine. https:\/\/doi.org\/10.1155\/2022\/6627104","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"key":"5333_CR97","doi-asserted-by":"crossref","unstructured":"Ghorbanpour A, Salari S, Baluchnejadmojarad ZT, Roghani M (2023) Capsaicin protects against septic acute liver injury by attenuation of apoptosis and mitochondrial dysfunction.\u00a0Heliyon\u00a09(3).","DOI":"10.1016\/j.heliyon.2023.e14205"},{"issue":"9","key":"5333_CR98","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1292\/jvms.19-0281","volume":"81","author":"MA Shah","year":"2019","unstructured":"Shah MA, Park DJ, Kang JB, Kim MO, Koh PO (2019) Baicalin attenuates lipopolysaccharide-induced neuroinflammation in cerebral cortex of mice via inhibiting nuclear factor kappa B (NF-\u03baB) activation. J Vet Med Sci 81(9):1359\u20131367","journal-title":"J Vet Med Sci"},{"issue":"5","key":"5333_CR99","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1080\/14786419.2019.1608537","volume":"35","author":"M Herrera-Ruiz","year":"2021","unstructured":"Herrera-Ruiz M, Jim\u00e9nez-Ferrer E, Tortoriello J, Zamilpa A, Alegr\u00eda-Herrera E, Jim\u00e9nez-Aparicio AR, Arenas-Ocampo ML, Mart\u00ednez-Duncker I, et al. (2021) Anti-neuroinflammatory effect of agaves and cantalasaponin-1 in a model of LPS-induced damage. Nat Prod Res 35(5):884\u2013887","journal-title":"Nat Prod Res"},{"issue":"3","key":"5333_CR100","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.cyto.2011.09.022","volume":"56","author":"C Rummel","year":"2011","unstructured":"Rummel C, Gerstberger R, Roth J, H\u00fcbschle T (2011) Parthenolide attenuates LPS-induced fever, circulating cytokines and markers of brain inflammation in rats. Cytokine 56(3):739\u2013748","journal-title":"Cytokine"},{"issue":"4","key":"5333_CR101","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.mcn.2007.01.011","volume":"34","author":"DR Riddell","year":"2007","unstructured":"Riddell DR, Zhou H, Comery TA, Kouranova E, Lo CF, Warwick HK, Jacobsen JS (2007) The LXR agonist TO901317 selectively lowers hippocampal A\u03b242 and improves memory in the Tg2576 mouse model of Alzheimer\u2019s disease. Mol Cell Neurosci 34(4):621\u2013628","journal-title":"Mol Cell Neurosci"},{"key":"5333_CR102","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1007\/s00702-010-0433-4","volume":"117","author":"CD Lee","year":"2010","unstructured":"Lee CD, Landreth GE (2010) The role of microglia in amyloid clearance from the AD brain. J Neural Transm 117:949\u2013960","journal-title":"J Neural Transm"},{"issue":"36","key":"5333_CR103","doi-asserted-by":"publisher","first-page":"8240","DOI":"10.1523\/JNEUROSCI.1808-05.2005","volume":"25","author":"J Koenigsknecht-Talboo","year":"2005","unstructured":"Koenigsknecht-Talboo J, Landreth GE (2005) Microglial phagocytosis induced by fibrillar \u03b2-amyloid and IgGs are differentially regulated by proinflammatory cytokines. J Neurosci 25(36):8240\u20138249","journal-title":"J Neurosci"},{"key":"5333_CR104","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.bbrc.2021.12.071","volume":"590","author":"H Jiao","year":"2022","unstructured":"Jiao H, Jia J (2022) Ginsenoside compound K acts via LRP1 to alleviate amyloid \u03b242-induced neuroinflammation in microglia by suppressing NF-\u03baB. Biochem Biophys Res Commun 590:14\u201319","journal-title":"Biochem Biophys Res Commun"},{"issue":"52","key":"5333_CR105","doi-asserted-by":"publisher","first-page":"14470","DOI":"10.1523\/JNEUROSCI.4823-07.2007","volume":"27","author":"JJ Repa","year":"2007","unstructured":"Repa JJ, Li H, Frank-Cannon TC, Valasek MA, Turley SD, Tansey MG, Dietschy JM (2007) Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse. J Neurosci 27(52):14470\u201314480","journal-title":"J Neurosci"},{"issue":"1\u20132","key":"5333_CR106","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jneuroim.2010.08.021","volume":"230","author":"H Hwang","year":"2011","unstructured":"Hwang H, Jeon H, Ock J, Hong SH, Han YM, Kwon BM, Suk K (2011) 2\u2032-Hydroxycinnamaldehyde targets low-density lipoprotein receptor-related protein-1 to inhibit lipopolysaccharide-induced microglial activation. J Neuroimmunol 230(1\u20132):52\u201364","journal-title":"J Neuroimmunol"},{"issue":"1","key":"5333_CR107","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0002-9440(10)64354-4","volume":"160","author":"IS Coraci","year":"2002","unstructured":"Coraci IS, Husemann J, Berman JW, Hulette C, Dufour JH, Campanella GK, El Khoury JB (2002) CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer\u2019s disease brains and can mediate production of reactive oxygen species in response to \u03b2-amyloid fibrils. Am J Pathol 160(1):101\u2013112","journal-title":"Am J Pathol"},{"issue":"9","key":"5333_CR108","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1093\/abbs\/gmt074","volume":"45","author":"S Zhang","year":"2013","unstructured":"Zhang S, Yang L, Kouadir M, Tan R, Lu Y, Chang J, Zhao D (2013) PP2 and piceatannol inhibit PrP106\u2013126-induced iNOS activation mediated by CD36 in BV2 microglia. Acta Biochim Biophys Sin 45(9):763\u2013772","journal-title":"Acta Biochim Biophys Sin"},{"issue":"1","key":"5333_CR109","doi-asserted-by":"publisher","first-page":"887","DOI":"10.3233\/ADR-210052","volume":"5","author":"CM Monoranu","year":"2021","unstructured":"Monoranu CM, Hartmann T, Strobel S, Heinsen H, Riederer P, Distel L, Bohnert S (2021) Is there any evidence of monocytes involvement in Alzheimer\u2019s disease? A pilot study on human postmortem brain. J Alzheimers Dis Rep 5(1):887\u2013897","journal-title":"J Alzheimers Dis Rep"},{"issue":"1","key":"5333_CR110","doi-asserted-by":"publisher","first-page":"93","DOI":"10.2174\/138161206780574579","volume":"12","author":"A Bernardo","year":"2006","unstructured":"Bernardo A, Minghetti L (2006) PPAR-\u03b3 agonists as regulators of microglial activation and brain inflammation. Curr Pharm Des 12(1):93\u2013109","journal-title":"Curr Pharm Des"},{"issue":"7","key":"5333_CR111","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1007\/s11011-021-00741-4","volume":"36","author":"SS El-Din","year":"2021","unstructured":"El-Din SS, Abd Elwahab S, Rashed L, Fayez S, Aboulhoda BE, Heikal OA, Nour ZA (2021) Possible role of rice bran extract in microglial modulation through PPAR-gamma receptors in Alzheimer\u2019s disease mice model. Metab Brain Dis 36(7):1903\u20131915","journal-title":"Metab Brain Dis"},{"issue":"3","key":"5333_CR112","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s13311-019-00731-6","volume":"16","author":"AM Petrov","year":"2019","unstructured":"Petrov AM, Pikuleva IA (2019) Cholesterol 24-hydroxylation by CYP46A1: benefits of modulation for brain diseases. Neurotherapeutics 16(3):635\u2013648","journal-title":"Neurotherapeutics"},{"issue":"4","key":"5333_CR113","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1194\/jlr.M034124","volume":"54","author":"Z Ali","year":"2013","unstructured":"Ali Z, Heverin M, Olin M, Acimovic J, L\u00f6vgren-Sandblom A, Shafaati M, Bj\u00f6rkhem I (2013) On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1\u2212\/\u2212 mice1. J Lipid Res 54(4):1033\u20131043","journal-title":"J Lipid Res"},{"key":"5333_CR114","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1007\/s12031-020-01758-7","volume":"71","author":"S Na","year":"2021","unstructured":"Na S, Duan X, Wang R, Fan Y, Xue K, Tian S, Yue J (2021) Chronic neuroinflammation induced by lipopolysaccharide injection into the third ventricle induces behavioral changes. J Mol Neurosci 71:1306\u20131319","journal-title":"J Mol Neurosci"},{"key":"5333_CR115","doi-asserted-by":"crossref","unstructured":"de C\u00e1ssia da Silveira e S\u00e1 R, Andrade LN, de Sousa DP (2013) A review on antiinflammatory activity of monoterpenes. Molecules18(1): 1227\u201354","DOI":"10.3390\/molecules18011227"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05333-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-05333-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05333-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:04:16Z","timestamp":1767992656000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-05333-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,6]]},"references-count":115,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5333"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-05333-2","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,6]]},"assertion":[{"value":"16 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original version of this paper was updated to update Affiliation 2 and Experimental design Table.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"262"}}