{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:51:45Z","timestamp":1775595105472,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Fund from Medical Science Research Project of Hebei Province","award":["20250005"],"award-info":[{"award-number":["20250005"]}]},{"name":"Fund from Medical Science Research Project of Hebei Province","award":["20250176"],"award-info":[{"award-number":["20250176"]}]},{"name":"The Natural Science Foundation of Hebei Province","award":["H2023206361"],"award-info":[{"award-number":["H2023206361"]}]},{"name":"Science Research Project of Hebei Education Department","award":["QN2024011"],"award-info":[{"award-number":["QN2024011"]}]},{"name":"Key laboratory of Neural and Vascular Biology, Ministry of Education of China project","award":["NV20230007"],"award-info":[{"award-number":["NV20230007"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-025-05384-5","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T06:52:45Z","timestamp":1763794365000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of Axonal Regeneration-Related Genes and a Potential Analgesic Drug for Neuropathic Pain"],"prefix":"10.1007","volume":"63","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shikang","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yabin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guona","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,22]]},"reference":[{"issue":"8","key":"5384_CR1","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/S1474-4422(10)70143-5","volume":"9","author":"R Baron","year":"2010","unstructured":"Baron R, Binder A, Wasner G (2010) Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol 9(8):807\u2013819","journal-title":"Lancet Neurol"},{"issue":"4","key":"5384_CR2","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.mayocp.2015.01.018","volume":"90","author":"I Gilron","year":"2015","unstructured":"Gilron I, Baron R, Jensen T (2015) Neuropathic pain: principles of diagnosis and treatment. Mayo Clin Proc 90(4):532\u2013545","journal-title":"Mayo Clin Proc"},{"issue":"4","key":"5384_CR3","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.3892\/etm.2017.4102","volume":"13","author":"Y Wang","year":"2017","unstructured":"Wang Y, Yang H, Shen C, Luo J (2017) Morphine and pregabalin in the treatment of neuropathic pain. Exp Ther Med 13(4):1393\u20131397","journal-title":"Exp Ther Med"},{"key":"5384_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2023.108546","volume":"251","author":"M Thouaye","year":"2023","unstructured":"Thouaye M, Yalcin I (2023) Neuropathic pain: from actual pharmacological treatments to new therapeutic horizons. Pharmacol Ther 251:108546","journal-title":"Pharmacol Ther"},{"issue":"7","key":"5384_CR5","doi-asserted-by":"publisher","first-page":"4596","DOI":"10.1007\/s12035-015-9397-6","volume":"53","author":"FM Mar","year":"2016","unstructured":"Mar FM, Sim\u00f5es AR, Rodrigo IS, Sousa MM (2016) Inhibitory injury signaling represses axon regeneration after dorsal root injury. Mol Neurobiol 53(7):4596\u20134605","journal-title":"Mol Neurobiol"},{"issue":"5","key":"5384_CR6","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.neuron.2016.01.034","volume":"89","author":"V Chandran","year":"2016","unstructured":"Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA et al (2016) A systems-level analysis of the peripheral nerve intrinsic axonal growth program. Neuron 89(5):956\u2013970","journal-title":"Neuron"},{"issue":"9","key":"5384_CR7","first-page":"2056","volume":"18","author":"LL Zhao","year":"2023","unstructured":"Zhao LL, Zhang T, Huang WX, Guo TT, Gu XS (2023) Transcriptional regulatory network during axonal regeneration of dorsal root ganglion neurons: laser-capture microdissection and deep sequencing. Neural Regen Res 18(9):2056\u20132066","journal-title":"Neural Regen Res"},{"issue":"5","key":"5384_CR8","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1158\/1535-7163.MCT-14-0866","volume":"14","author":"B Lelj-Garolla","year":"2015","unstructured":"Lelj-Garolla B, Kumano M, Beraldi E, Nappi L, Rocchi P, Ionescu DN et al (2015) Hsp27 inhibition with OGX-427 sensitizes non-small cell lung cancer cells to erlotinib and chemotherapy. Mol Cancer Ther 14(5):1107\u20131116","journal-title":"Mol Cancer Ther"},{"issue":"3","key":"5384_CR9","first-page":"1119","volume":"39","author":"T Shimada","year":"2018","unstructured":"Shimada T, Tsuruta M, Hasegawa H, Okabayashi K, Shigeta K, Ishida T et al (2018) Heat shock protein 27 knockdown using nucleotide-based therapies enhances sensitivity to 5-FU chemotherapy in SW480 human colon cancer cells. Oncol Rep 39(3):1119\u20131124","journal-title":"Oncol Rep"},{"issue":"6","key":"5384_CR10","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1093\/annonc\/mdw068","volume":"27","author":"KN Chi","year":"2016","unstructured":"Chi KN, Yu EY, Jacobs C, Bazov J, Kollmannsberger C, Higano CS et al (2016) A phase I dose-escalation study of apatorsen (OGX-427), an antisense inhibitor targeting heat shock protein 27 (Hsp27), in patients with castration-resistant prostate cancer and other advanced cancers. Ann Oncol 27(6):1116\u20131122","journal-title":"Ann Oncol"},{"issue":"2","key":"5384_CR11","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s12035-023-03582-7","volume":"61","author":"TY Yeh","year":"2024","unstructured":"Yeh TY, Chang MF, Kan YY, Chiang H, Hsieh ST (2024) HSP27 modulates neuropathic pain by inhibiting P2X3 degradation. Mol Neurobiol 61(2):707\u2013724","journal-title":"Mol Neurobiol"},{"issue":"1","key":"5384_CR12","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1023\/A:1021601103096","volume":"8","author":"CG Concannon","year":"2003","unstructured":"Concannon CG, Gorman AM, Samali A (2003) On the role of Hsp27 in regulating apoptosis. Apoptosis 8(1):61\u201370","journal-title":"Apoptosis"},{"issue":"6","key":"5384_CR13","doi-asserted-by":"publisher","first-page":"670","DOI":"10.18097\/PBMC20166206670","volume":"62","author":"OL Nosareva","year":"2016","unstructured":"Nosareva OL, Ryazantseva NV, Stepovaya EA, Shakhristova EV, Stepanova EA, Gulaya VS (2016) Uchastie belkov teplovogo shoka 27 i 70 v redoks-zavisimo\u012d reguliatsii apoptoza opukholevykh kletok linii Jurkat [The role of heat shock proteins 27 and 70 in redox-dependent regulation of apoptosis in Jurkat tumor cells]. Biomed Khim 62(6):670\u2013673","journal-title":"Biomed Khim"},{"issue":"10","key":"5384_CR14","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1016\/j.biocel.2012.05.024","volume":"44","author":"G Wettstein","year":"2012","unstructured":"Wettstein G, Bellaye PS, Micheau O, Bonniaud P (2012) Small heat shock proteins and the cytoskeleton: an essential interplay for cell integrity. Int J Biochem Cell Biol 44(10):1680\u20131686","journal-title":"Int J Biochem Cell Biol"},{"issue":"5","key":"5384_CR15","doi-asserted-by":"publisher","first-page":"6718","DOI":"10.1096\/fj.201902936R","volume":"34","author":"H Vicente Miranda","year":"2020","unstructured":"Vicente Miranda H, Cheg\u00e3o A, Oliveira MS, Fernandes Gomes B, Enguita FJ, Outeiro TF (2020) Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein. FASEB J 34(5):6718\u20136728","journal-title":"FASEB J"},{"issue":"7","key":"5384_CR16","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1007\/s00424-020-02419-9","volume":"472","author":"MD Baker","year":"2020","unstructured":"Baker MD, Nassar MA (2020) Painful and painless mutations of SCN9A and SCN11A voltage-gated sodium channels. Pflugers Arch 472(7):865\u2013880","journal-title":"Pflugers Arch"},{"issue":"3","key":"5384_CR17","first-page":"321","volume":"33","author":"L Casals-D\u00edaz","year":"2015","unstructured":"Casals-D\u00edaz L, Casas C, Navarro X (2015) Changes of voltage-gated sodium channels in sensory nerve regeneration and neuropathic pain models. Restor Neurol Neurosci 33(3):321\u2013334","journal-title":"Restor Neurol Neurosci"},{"key":"5384_CR18","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0079-6123(08)61712-4","volume":"89","author":"SK Doster","year":"1991","unstructured":"Doster SK, Lozano AM, Schuh SM, Spencer S, Willard MB (1991) GAP-43: purification from a prokaryotic expression system, phosphorylation in cultured neurons, and regulation of synthesis in the central nervous system. Prog Brain Res 89:17\u201326","journal-title":"Prog Brain Res"},{"issue":"3","key":"5384_CR19","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.3390\/ijms21031016","volume":"21","author":"F Moradi","year":"2020","unstructured":"Moradi F, Copeland EN, Baranowski RW, Scholey AE, Stuart JA, Fajardo VA (2020) Calmodulin-binding proteins in muscle: a minireview on nuclear receptor interacting protein, neurogranin, and growth-associated protein 43. Int J Mol Sci 21(3):1016","journal-title":"Int J Mol Sci"},{"issue":"7","key":"5384_CR20","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1083\/jcb.149.7.1443","volume":"149","author":"D Frey","year":"2000","unstructured":"Frey D, Laux T, Xu L, Schneider C, Caroni P (2000) Shared and unique roles of CAP23 and GAP43 in actin regulation, neurite outgrowth, and anatomical plasticity. J Cell Biol 149(7):1443\u20131454","journal-title":"J Cell Biol"},{"issue":"8","key":"5384_CR21","first-page":"1516","volume":"6","author":"F Wu","year":"2013","unstructured":"Wu F, Miao X, Chen J, Liu Z, Tao Y, Yu W et al (2013) Inhibition of GAP-43 by propentofylline in a rat model of neuropathic pain. Int J Clin Exp Pathol 6(8):1516\u20131522","journal-title":"Int J Clin Exp Pathol"},{"issue":"9","key":"5384_CR22","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.semcdb.2010.08.008","volume":"221","author":"J Newbern","year":"2010","unstructured":"Newbern J, Birchmeier C (2010) Nrg1\/ErbB signaling networks in Schwann cell development and myelination. Semin Cell Dev Biol 221(9):922\u2013928","journal-title":"Semin Cell Dev Biol"},{"key":"5384_CR23","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.mri.2018.07.002","volume":"53","author":"S Wang","year":"2018","unstructured":"Wang S, Li Y, Paudyal R, Ford BD, Zhang X (2018) Evaluation of neuregulin-1\u2019s neuroprotection against ischemic injury in rats using diffusion tensor imaging. Magn Reson Imaging 53:63\u201370","journal-title":"Magn Reson Imaging"},{"issue":"9","key":"5384_CR24","first-page":"5916","volume":"7","author":"G Wang","year":"2014","unstructured":"Wang G, Dai D, Chen X, Yuan L, Zhang A, Lu Y et al (2014) Upregulation of neuregulin-1 reverses signs of neuropathic pain in rats. Int J Clin Exp Pathol 7(9):5916\u20135921","journal-title":"Int J Clin Exp Pathol"},{"issue":"8","key":"5384_CR25","volume":"8","author":"MC Ferraro","year":"2025","unstructured":"Ferraro MC, Cashin AG, Visser EJ, Abdel Shaheed C, Wewege MA, Wand BM et al (2025) Ketamine and other NMDA receptor antagonists for chronic pain. Cochrane Database Syst Rev 8(8):CD015373","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"5384_CR26","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.neuropharm.2010.12.030","volume":"60","author":"YS Gwak","year":"2011","unstructured":"Gwak YS, Hulsebosch CE (2011) GABA and central neuropathic pain following spinal cord injury. Neuropharmacology 60(5):799\u2013808","journal-title":"Neuropharmacology"},{"issue":"2","key":"5384_CR27","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1152\/physrev.00052.2017","volume":"99","author":"DL Bennett","year":"2019","unstructured":"Bennett DL, Clark AJ, Huang J, Waxman SG, Dib-Hajj SD (2019) The role of voltage-gated sodium channels in pain signaling. Physiol Rev 99(2):1079\u20131151","journal-title":"Physiol Rev"},{"key":"5384_CR28","doi-asserted-by":"publisher","first-page":"174480691986425","DOI":"10.1177\/1744806919864256","volume":"15","author":"A Abd-Elsayed","year":"2019","unstructured":"Abd-Elsayed A, Jackson M, Gu SL, Fiala K, Gu J (2019) Neuropathic pain and Kv7 voltage-gated potassium channels: the potential role of Kv7 activators in the treatment of neuropathic pain. Mol Pain 15:1744806919864256","journal-title":"Mol Pain"},{"key":"5384_CR29","doi-asserted-by":"publisher","first-page":"174480692311822","DOI":"10.1177\/17448069231182235","volume":"19","author":"H Ma","year":"2023","unstructured":"Ma H, Pan Z, Lai B, Li M, Wang J (2023) Contribution of immune cells to cancer-related neuropathic pain: an updated review. Mol Pain 19:17448069231182236","journal-title":"Mol Pain"},{"issue":"1","key":"5384_CR30","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1080\/21655979.2020.1771068","volume":"11","author":"Z Wang","year":"2020","unstructured":"Wang Z, Song K, Zhao W, Zhao Z (2020) Dendritic cells in tumor microenvironment promoted the neuropathic pain via paracrine inflammatory and growth factors. Bioengineered 11(1):661\u2013678","journal-title":"Bioengineered"},{"issue":"1","key":"5384_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0966-1","volume":"37","author":"YF Lu","year":"2018","unstructured":"Lu YF, Yu JR, Yang Z, Zhu GX, Gao P, Wang H et al (2018) Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC). J Exp Clin Cancer Res 37(1):301","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"5384_CR32","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1038\/s41467-018-03627-9","volume":"9","author":"M Sevin","year":"2018","unstructured":"Sevin M, Kubovcakova L, Pernet N, Causse S, Vitte F, Villeval JL (2018) HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis. Nat Commun 9(1):1431","journal-title":"Nat Commun"},{"issue":"11","key":"5384_CR33","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1038\/s41416-018-0087-9","volume":"118","author":"JE Rosenberg","year":"2018","unstructured":"Rosenberg JE, Hahn NM, Regan MM, Werner L, Alva A, George S (2018) Apatorsen plus docetaxel versus docetaxel alone in platinum-resistant metastatic urothelial carcinoma (Borealis-2). Br J Cancer 118(11):1434\u20131441","journal-title":"Br J Cancer"},{"issue":"3","key":"5384_CR34","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1097\/j.pain.0000000000000404","volume":"157","author":"L Ventzel","year":"2016","unstructured":"Ventzel L, Jensen AB, Jensen AR, Jensen TS, Finnerup NB (2016) Chemotherapy-induced pain and neuropathy: a prospective study in patients treated with adjuvant oxaliplatin or docetaxel. Pain 157(3):560\u2013568","journal-title":"Pain"},{"issue":"1-3","key":"5384_CR35","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ejphar.2010.09.037","volume":"649","author":"MC de Oliveira Fusaro","year":"2010","unstructured":"de Oliveira Fusaro MC, Pelegrini-da-Silva A, Araldi D, Parada CA, Tambeli CH (2010) P2X3 and P2X2\/3 receptors mediate mechanical hyperalgesia induced by bradykinin, but not by pro-inflammatory cytokines, PGE\u2082 or dopamine. Eur J Pharmacol 649(1\u20133):177\u2013182","journal-title":"Eur J Pharmacol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05384-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-05384-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05384-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T19:03:08Z","timestamp":1763838188000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-05384-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,22]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5384"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-05384-5","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,22]]},"assertion":[{"value":"20 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the animal experiments were carried out with the approval of the Laboratory Animal Ethical and Welfare Committee of HeBei Medical University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Aproval"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}],"article-number":"138"}}