{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:46:58Z","timestamp":1792237618064,"version":"4.4.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82171336"],"award-info":[{"award-number":["82171336"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82271518"],"award-info":[{"award-number":["82271518"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82471370"],"award-info":[{"award-number":["82471370"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-025-05387-2","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:10:54Z","timestamp":1764051054000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["IL17A Mediates Glycolysis-Dependent Primary Angiogenesis and Exacerbates Ischemic Stroke Injury"],"prefix":"10.1007","volume":"63","author":[{"given":"Qingxue","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqi","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingze","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohaib","family":"Shafiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxing","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"issue":"4","key":"5387_CR1","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s12975-016-0518-y","volume":"8","author":"PA Lapchak","year":"2017","unstructured":"Lapchak PA, Zhang JH (2017) The high cost of stroke and stroke cytoprotection research. Transl Stroke Res 8(4):307\u2013317","journal-title":"Transl Stroke Res"},{"issue":"2","key":"5387_CR2","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/imm.13265","volume":"162","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Liao Y, Liu Z, Dai Y, Li Y, Li Y et al (2021) Interleukin-17 and ischaemic stroke. Immunology 162(2):179\u2013193","journal-title":"Immunology"},{"key":"5387_CR3","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.bbi.2019.07.026","volume":"81","author":"Z Liu","year":"2019","unstructured":"Liu Z, Qiu AW, Huang Y, Yang Y, Chen JN, Gu TT et al (2019) IL-17A exacerbates neuroinflammation and neurodegeneration by activating microglia in rodent models of Parkinson\u2019s disease. Brain Behav Immun 81:630\u2013645","journal-title":"Brain Behav Immun"},{"issue":"5","key":"5387_CR4","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00401-015-1402-7","volume":"129","author":"A Waisman","year":"2015","unstructured":"Waisman A, Hauptmann J, Regen T (2015) The role of IL-17 in CNS diseases. Acta Neuropathol 129(5):625\u2013637","journal-title":"Acta Neuropathol"},{"issue":"6","key":"5387_CR5","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/ni.3742","volume":"18","author":"M Veldhoen","year":"2017","unstructured":"Veldhoen M (2017) Interleukin 17 is a chief orchestrator of immunity. Nat Immunol 18(6):612\u2013621","journal-title":"Nat Immunol"},{"key":"5387_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109926","volume":"117","author":"X Chen","year":"2023","unstructured":"Chen X, Zhang Y, Ding Q, He Y, Li H (2023) Role of IL-17A in different stages of ischemic stroke. Int Immunopharmacol 117:109926","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"5387_CR7","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/nrd3794","volume":"11","author":"P Miossec","year":"2012","unstructured":"Miossec P, Kolls JK (2012) Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov 11(10):763\u2013776","journal-title":"Nat Rev Drug Discov"},{"key":"5387_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-6-14","volume":"6","author":"J Das Sarma","year":"2009","unstructured":"Das Sarma J, Ciric B, Marek R, Sadhukhan S, Caruso ML, Shafagh J et al (2009) Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis. J Neuroinflammation 6:14","journal-title":"J Neuroinflammation"},{"key":"5387_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cca.2014.01.012","volume":"431","author":"XH Yu","year":"2014","unstructured":"Yu XH, Jiang N, Zheng XL, Cayabyab FS, Tang ZB, Tang CK (2014) Interleukin-17A in lipid metabolism and atherosclerosis. Clin Chim Acta 431:33\u201339","journal-title":"Clin Chim Acta"},{"issue":"9","key":"5387_CR10","doi-asserted-by":"publisher","first-page":"5619","DOI":"10.4049\/jimmunol.1001879","volume":"185","author":"S Chen","year":"2010","unstructured":"Chen S, Shimada K, Zhang W, Huang G, Crother TR, Arditi M (2010) IL-17A is proatherogenic in high-fat diet-induced and Chlamydia pneumoniae infection-accelerated atherosclerosis in mice. J Immunol 185(9):5619\u20135627","journal-title":"J Immunol"},{"issue":"15","key":"5387_CR11","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1161\/CIRCULATIONAHA.109.924886","volume":"121","author":"E Smith","year":"2010","unstructured":"Smith E, Prasad KM, Butcher M, Dobrian A, Kolls JK, Ley K et al (2010) Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice. Circulation 121(15):1746\u20131755","journal-title":"Circulation"},{"issue":"3","key":"5387_CR12","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/S0002-9440(10)64964-4","volume":"156","author":"HJ Marti","year":"2000","unstructured":"Marti HJ, Bernaudin M, Bellail A, Schoch H, Euler M, Petit E et al (2000) Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol 156(3):965\u2013976","journal-title":"Am J Pathol"},{"issue":"12","key":"5387_CR13","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.2174\/1570159X18666200720173316","volume":"18","author":"Y Yang","year":"2020","unstructured":"Yang Y, Torbey MT (2020) Angiogenesis and blood-brain barrier permeability in vascular remodeling after stroke. Curr Neuropharmacol 18(12):1250\u20131265","journal-title":"Curr Neuropharmacol"},{"issue":"1","key":"5387_CR14","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/s12974-016-0733-1","volume":"13","author":"R Lin","year":"2016","unstructured":"Lin R, Cai J, Kostuk EW, Rosenwasser R, Iacovitti L (2016) Fumarate modulates the immune\/inflammatory response and rescues nerve cells and neurological function after stroke in rats. J Neuroinflammation 13(1):269","journal-title":"J Neuroinflammation"},{"issue":"24","key":"5387_CR15","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1161\/CIRCULATIONAHA.122.061900","volume":"146","author":"W Zhou","year":"2022","unstructured":"Zhou W, Liu K, Zeng L, He J, Gao X, Gu X et al (2022) Targeting VEGF-A\/VEGFR2 Y949 signaling-mediated vascular permeability alleviates hypoxic pulmonary hypertension. Circulation 146(24):1855\u20131881","journal-title":"Circulation"},{"issue":"9","key":"5387_CR16","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1161\/CIRCRESAHA.116.310477","volume":"120","author":"K Heinolainen","year":"2017","unstructured":"Heinolainen K, Karaman S, D\u2019Amico G, Tammela T, Sormunen R, Eklund L et al (2017) VEGFR3 modulates vascular permeability by controlling VEGF\/VEGFR2 signaling. Circ Res 120(9):1414\u20131425","journal-title":"Circ Res"},{"key":"5387_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106208","volume":"179","author":"J Yan","year":"2022","unstructured":"Yan J, Li A, Chen X, Cao K, Song M, Guo S et al (2022) Glycolysis inhibition ameliorates brain injury after ischemic stroke by promoting the function of myeloid-derived suppressor cells. Pharmacol Res 179:106208","journal-title":"Pharmacol Res"},{"issue":"6602","key":"5387_CR18","doi-asserted-by":"publisher","first-page":"eabg9302","DOI":"10.1126\/science.abg9302","volume":"377","author":"P Konieczny","year":"2022","unstructured":"Konieczny P, Xing Y, Sidhu I, Subudhi I, Mansfield KP, Hsieh B et al (2022) Interleukin-17 governs hypoxic adaptation of injured epithelium. Science 377(6602):eabg9302","journal-title":"Science"},{"issue":"1","key":"5387_CR19","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s12974-021-02316-7","volume":"18","author":"M Piepke","year":"2021","unstructured":"Piepke M, Clausen BH, Ludewig P, Vienhues JH, Bedke T, Javidi E et al (2021) Interleukin-10 improves stroke outcome by controlling the detrimental interleukin-17A response. J Neuroinflammation 18(1):265","journal-title":"J Neuroinflammation"},{"issue":"1","key":"5387_CR20","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s00395-021-00881-9","volume":"116","author":"J Gregorius","year":"2021","unstructured":"Gregorius J, Wang C, Stambouli O, Hussner T, Qi Y, Tertel T et al (2021) Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice. Basic Res Cardiol 116(1):40","journal-title":"Basic Res Cardiol"},{"issue":"1\u20132","key":"5387_CR21","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jneuroim.2007.11.006","volume":"194","author":"J Kawanokuchi","year":"2008","unstructured":"Kawanokuchi J, Shimizu K, Nitta A, Yamada K, Mizuno T, Takeuchi H et al (2008) Production and functions of IL-17 in microglia. J Neuroimmunol 194(1\u20132):54\u201361","journal-title":"J Neuroimmunol"},{"issue":"10","key":"5387_CR22","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/nm1651","volume":"13","author":"H Kebir","year":"2007","unstructured":"Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M et al (2007) Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med 13(10):1173\u20131175","journal-title":"Nat Med"},{"issue":"7","key":"5387_CR23","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1161\/01.STR.0000170712.46106.2e","volume":"36","author":"Y Zhu","year":"2005","unstructured":"Zhu Y, Lee C, Shen F, Du R, Young WL, Yang GY (2005) Angiopoietin-2 facilitates vascular endothelial growth factor-induced angiogenesis in the mature mouse brain. Stroke 36(7):1533\u20131537","journal-title":"Stroke"},{"issue":"4","key":"5387_CR24","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1161\/01.CIR.0000046451.38849.90","volume":"107","author":"J Montaner","year":"2003","unstructured":"Montaner J, Molina CA, Monasterio J, Abilleira S, Arenillas JF, Rib\u00f3 M et al (2003) Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke. Circulation 107(4):598\u2013603","journal-title":"Circulation"},{"key":"5387_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00056","volume":"10","author":"RJ Turner","year":"2016","unstructured":"Turner RJ, Sharp FR (2016) Implications of MMP9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke. Front Cell Neurosci 10:56","journal-title":"Front Cell Neurosci"},{"issue":"4","key":"5387_CR26","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1007\/s10456-021-09796-4","volume":"24","author":"CC Tsao","year":"2021","unstructured":"Tsao CC, Baumann J, Huang SF, Kindler D, Schroeter A, Kachappilly N et al (2021) Pericyte hypoxia-inducible factor-1 (HIF-1) drives blood-brain barrier disruption and impacts acute ischemic stroke outcome. Angiogenesis 24(4):823\u2013842","journal-title":"Angiogenesis"},{"issue":"4","key":"5387_CR27","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/74651","volume":"6","author":"P Carmeliet","year":"2000","unstructured":"Carmeliet P (2000) Mechanisms of angiogenesis and arteriogenesis. Nat Med 6(4):389\u2013395","journal-title":"Nat Med"},{"issue":"7","key":"5387_CR28","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/s41401-023-01061-2","volume":"44","author":"J Fang","year":"2023","unstructured":"Fang J, Wang Z, Miao CY (2023) Angiogenesis after ischemic stroke. Acta Pharmacol Sin 44(7):1305\u20131321","journal-title":"Acta Pharmacol Sin"},{"key":"5387_CR29","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.brainres.2009.06.073","volume":"1288","author":"YP Yan","year":"2009","unstructured":"Yan YP, Lang BT, Vemuganti R, Dempsey RJ (2009) Galectin-3 mediates post-ischemic tissue remodeling. Brain Res 1288:116\u2013124","journal-title":"Brain Res"},{"issue":"2","key":"5387_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.940","volume":"10","author":"I Uehara","year":"2022","unstructured":"Uehara I, Kajita M, Tanimura A, Hida S, Onda M, Naito Z et al (2022) 2-deoxy-d-glucose induces deglycosylation of proinflammatory cytokine receptors and strongly reduces immunological responses in mouse models of inflammation. Pharmacol Res Perspect 10(2):e00940","journal-title":"Pharmacol Res Perspect"},{"key":"5387_CR31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ejca.2019.09.005","volume":"123","author":"S Singh","year":"2019","unstructured":"Singh S, Pandey S, Chawla AS, Bhatt AN, Roy BG, Saluja D et al (2019) Dietary 2-deoxy-D-glucose impairs tumour growth and metastasis by inhibiting angiogenesis. Eur J Cancer 123:11\u201324","journal-title":"Eur J Cancer"},{"issue":"1","key":"5387_CR32","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12974-021-02187-y","volume":"18","author":"J Cheng","year":"2021","unstructured":"Cheng J, Zhang R, Xu Z, Ke Y, Sun R, Yang H et al (2021) Early glycolytic reprogramming controls microglial inflammatory activation. J Neuroinflammation 18(1):129","journal-title":"J Neuroinflammation"},{"issue":"18","key":"5387_CR33","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1016\/j.neuron.2023.06.013","volume":"111","author":"A Kumar","year":"2023","unstructured":"Kumar A, Karuppagounder SS, Chen Y, Corona C, Kawaguchi R, Cheng Y et al (2023) 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer\u2019s resilience. Neuron 111(18):2831\u201346.e10","journal-title":"Neuron"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05387-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-05387-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05387-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T19:03:11Z","timestamp":1764097391000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-05387-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5387"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-05387-2","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"29 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were approved by the Animal Experiment Center of Wuhan University (20230603E).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"169"}}