{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:23:42Z","timestamp":1777663422809,"version":"3.51.4"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-025-05395-2","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T03:48:09Z","timestamp":1763610489000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anxiolytic-Like Effects of Citronellal and Phytol, Possibly Through the GABAergic Interaction Pathway: In Vivo with Molecular Docking Studies"],"prefix":"10.1007","volume":"63","author":[{"given":"Md. Torequl","family":"Islam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Sakib","family":"Al Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannatul","family":"Ferdous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Y.","family":"Alshahrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emon","family":"Mia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Asaduzzaman","family":"Jony","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Nasimul Haque","family":"Shipon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Mohamod Wasaf","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md.","family":"Saifuzzaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"issue":"3","key":"5395_CR1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.31887\/DCNS.2015.17.3\/macrocq","volume":"17","author":"MA Crocq","year":"2015","unstructured":"Crocq MA (2015) A history of anxiety: from Hippocrates to DSM. Dialogues Clin Neurosci 17(3):319\u2013325. https:\/\/doi.org\/10.31887\/DCNS.2015.17.3\/macrocq","journal-title":"Dialogues Clin Neurosci"},{"key":"5395_CR2","unstructured":"Niknejad N (2025) Mental health and where you live: exploring relationships between walkability, green space, depression and anxiety. University of British Columbia,"},{"issue":"5","key":"5395_CR3","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.phymed.2010.08.017","volume":"18","author":"C Wasowski","year":"2011","unstructured":"Wasowski C, Marder M (2011) Central nervous system activities of two diterpenes isolated from Aloysia virgata. Phytomedicine 18(5):393\u2013401. https:\/\/doi.org\/10.1016\/j.phymed.2010.08.017","journal-title":"Phytomedicine"},{"issue":"24","key":"5395_CR4","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.2106\/jbjs.22.00516","volume":"104","author":"BA Hozack","year":"2022","unstructured":"Hozack BA, Kistler JM, Vaccaro AR, Beredjiklian PK (2022) Benzodiazepines and related drugs in orthopaedics. J Bone Joint Surg Am 104(24):2204\u20132210. https:\/\/doi.org\/10.2106\/jbjs.22.00516","journal-title":"J Bone Joint Surg Am"},{"key":"5395_CR5","unstructured":"Kang M, Galuska MA, Ghassemzadeh S (2025) Benzodiazepine toxicity. In: StatPearls. StatPearls Publishing Copyright \u00a9 2025, StatPearls Publishing LLC., Treasure Island (FL),"},{"key":"5395_CR6","doi-asserted-by":"publisher","first-page":"856846","DOI":"10.3389\/fphar.2022.856846","volume":"13","author":"JDS Souza","year":"2022","unstructured":"Souza JDS, Zuardi AW, Guimar\u00e3es FS, Os\u00f3rio FL, Loureiro SR, Campos AC, Hallak JEC, Dos Santos RG et al (2022) Maintained anxiolytic effects of cannabidiol after treatment discontinuation in healthcare workers during the COVID-19 pandemic. Front Pharmacol 13:856846. https:\/\/doi.org\/10.3389\/fphar.2022.856846","journal-title":"Front Pharmacol"},{"issue":"5","key":"5395_CR7","doi-asserted-by":"publisher","first-page":"893","DOI":"10.5665\/sleep.3654","volume":"37","author":"DJ Meyerhoff","year":"2014","unstructured":"Meyerhoff DJ, Mon A, Metzler T, Neylan TC (2014) Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality. Sleep 37(5):893\u2013900. https:\/\/doi.org\/10.5665\/sleep.3654","journal-title":"Sleep"},{"key":"5395_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25081844","author":"EK Akkol","year":"2020","unstructured":"Akkol EK, Ilhan M, Karpuz B, Gen\u00e7 Y, Sobarzo-S\u00e1nchez E (2020) Sedative and anxiolytic activities of Opuntia ficus indica (L.) Mill.: an experimental assessment in mice. Molecules. https:\/\/doi.org\/10.3390\/molecules25081844","journal-title":"Molecules"},{"issue":"Pt A","key":"5395_CR9","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.neuropharm.2018.01.036","volume":"136","author":"RW Olsen","year":"2018","unstructured":"Olsen RW (2018) GABA(A) receptor: positive and negative allosteric modulators. Neuropharmacology 136(Pt A):10\u201322. https:\/\/doi.org\/10.1016\/j.neuropharm.2018.01.036","journal-title":"Neuropharmacology"},{"issue":"2","key":"5395_CR10","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1111\/j.1476-5381.2011.01779.x","volume":"166","author":"W Sieghart","year":"2012","unstructured":"Sieghart W, Ramerstorfer J, Sarto-Jackson I, Varagic Z, Ernst M (2012) A novel GABA(A) receptor pharmacology: drugs interacting with the \u03b1(+) \u03b2(-) interface. Br J Pharmacol 166(2):476\u2013485. https:\/\/doi.org\/10.1111\/j.1476-5381.2011.01779.x","journal-title":"Br J Pharmacol"},{"key":"5395_CR11","volume":"5","author":"MT Islam","year":"2024","unstructured":"Islam MT, Prottay AAS, Akbor MS, Bhuia MS, Islam MA, Saifiuzzaman M (2024) Anxiolytic-like effect of daidzin possibly through GABAA receptor \u03b12 and \u03b13 subunits interaction pathway: in vivo and in silico studies. Pharmacol Res Nat Prod 5:100090","journal-title":"Pharmacol Res Nat Prod"},{"issue":"34","key":"5395_CR12","doi-asserted-by":"publisher","first-page":"4943","DOI":"10.2174\/1381612821666150914121624","volume":"21","author":"MJ Jembrek","year":"2015","unstructured":"Jembrek MJ, Vlainic J (2015) GABA receptors: pharmacological potential and pitfalls. Curr Pharm Des 21(34):4943\u20134959. https:\/\/doi.org\/10.2174\/1381612821666150914121624","journal-title":"Curr Pharm Des"},{"issue":"8","key":"5395_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043054","volume":"7","author":"CH Vinkers","year":"2012","unstructured":"Vinkers CH, van Oorschot R, Nielsen E, Cook JM, Hansen HH, Groenink L, Olivier B, Mirza NR (2012) GABA(A) receptor \u03b1 subunits differentially contribute to diazepam tolerance after chronic treatment. PLoS One 7(8):e43054. https:\/\/doi.org\/10.1371\/journal.pone.0043054","journal-title":"PLoS One"},{"issue":"3","key":"5395_CR14","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","volume":"79","author":"DJ Newman","year":"2016","unstructured":"Newman DJ, Cragg GM (2016) Natural products as sources of new drugs from 1981 to 2014. J Nat Prod 79(3):629\u2013661. https:\/\/doi.org\/10.1021\/acs.jnatprod.5b01055","journal-title":"J Nat Prod"},{"key":"5395_CR15","doi-asserted-by":"publisher","first-page":"100930","DOI":"10.1016\/j.focha.2025.100930","volume":"6","author":"KK Sharma","year":"2025","unstructured":"Sharma KK, Al Hasan MS, Rouf R, Emon Y, Mia E, Hossan R, Hossain MA, Shipon MNH, et al. (2025) Assessment of antiemetic and modulatory activity of dihydrocoumarin on copper sulfate induced emetic chicks: an in vivo investigation. Food Chemistry Advances 6:100930","journal-title":"Food Chemistry Advances"},{"issue":"4","key":"5395_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2022.100375","volume":"2","author":"N Phootha","year":"2022","unstructured":"Phootha N, Yongparnichkul N, Fang Z, Gan R-Y, Zhang P (2022) Plants and phytochemicals potentials in tackling anxiety: a systematic review. Phytomedicine Plus 2(4):100375","journal-title":"Phytomedicine Plus"},{"issue":"5","key":"5395_CR17","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1080\/14786419.2024.2332949","volume":"39","author":"AN Venancio","year":"2025","unstructured":"Venancio AN, Silva MJ, Parreira LA, J\u00falio AA, Souza GR, Concei\u00e7\u00e3o Santos MF, Menini L (2025) Citronellal: a natural aldehyde with important properties. Nat Prod Res 39(5):1199\u20131212. https:\/\/doi.org\/10.1080\/14786419.2024.2332949","journal-title":"Nat Prod Res"},{"key":"5395_CR18","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.fct.2018.08.032","volume":"121","author":"MT Islam","year":"2018","unstructured":"Islam MT, Ali ES, Uddin SJ, Shaw S, Islam MA, Ahmed MI, Chandra Shill M, Karmakar UK et al (2018) Phytol: a review of biomedical activities. Food Chem Toxicol 121:82\u201394. https:\/\/doi.org\/10.1016\/j.fct.2018.08.032","journal-title":"Food Chem Toxicol"},{"key":"5395_CR19","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.brainres.2013.12.003","volume":"1547","author":"JP Costa","year":"2014","unstructured":"Costa JP, de Oliveira GA, de Almeida AA, Islam MT, de Sousa DP, de Freitas RM (2014) Anxiolytic-like effects of phytol: possible involvement of GABAergic transmission. Brain Res 1547:34\u201342. https:\/\/doi.org\/10.1016\/j.brainres.2013.12.003","journal-title":"Brain Res"},{"issue":"8","key":"5395_CR20","doi-asserted-by":"publisher","first-page":"567","DOI":"10.3109\/15376516.2014.955230","volume":"24","author":"MJ Silva","year":"2014","unstructured":"Silva MJ, Vilegas W, da Silva MA, de Moura CF, Ribeiro FA, da Silva VH, Ribeiro DA (2014) Mimosa (Mimosa caesalpiniifolia) prevents oxidative DNA damage induced by cadmium exposure in Wistar rats. Toxicol Mech Methods 24(8):567\u2013574. https:\/\/doi.org\/10.3109\/15376516.2014.955230","journal-title":"Toxicol Mech Methods"},{"issue":"4","key":"5395_CR21","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.tins.2011.01.004","volume":"34","author":"KR Tan","year":"2011","unstructured":"Tan KR, Rudolph U, L\u00fcscher C (2011) Hooked on benzodiazepines: GABAA receptor subtypes and addiction. Trends Neurosci 34(4):188\u2013197. https:\/\/doi.org\/10.1016\/j.tins.2011.01.004","journal-title":"Trends Neurosci"},{"key":"5395_CR22","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.brainres.2012.01.070","volume":"1448","author":"AA de Almeida","year":"2012","unstructured":"de Almeida AA, Costa JP, de Carvalho RB, de Sousa DP, de Freitas RM (2012) Evaluation of acute toxicity of a natural compound (+)-limonene epoxide and its anxiolytic-like action. Brain Res 1448:56\u201362. https:\/\/doi.org\/10.1016\/j.brainres.2012.01.070","journal-title":"Brain Res"},{"key":"5395_CR23","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1590\/S0102-695X2008000400004","volume":"18","author":"N Subhan","year":"2008","unstructured":"Subhan N, Alam MA, Ahmed F, Shahid IJ, Nahar L, Sarker SD (2008) Bioactivity of Excoecaria agallocha. Rev Bras Farmacogn 18:521\u2013526","journal-title":"Rev Bras Farmacogn"},{"key":"5395_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/biom12101425","author":"SK Burley","year":"2022","unstructured":"Burley SK, Berman HM, Duarte JM, Feng Z, Flatt JW, Hudson BP, Lowe R, Peisach E et al (2022) Protein data bank: a comprehensive review of 3D structure holdings and worldwide utilization by researchers, educators, and students. Biomolecules. https:\/\/doi.org\/10.3390\/biom12101425","journal-title":"Biomolecules"},{"issue":"4","key":"5395_CR25","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-023-03520-3","volume":"13","author":"MS Bhuia","year":"2023","unstructured":"Bhuia MS, Islam T, Rokonuzzman M, ShamshProttay AA, Akter F, Hossain MI, Chowdhury R, Kazi MA et al (2023) Modulatory effects of phytol on the antiemetic property of domperidone, possibly through the D(2) receptor interaction pathway: in vivo and in silico studies. 3 Biotech 13(4):116. https:\/\/doi.org\/10.1007\/s13205-023-03520-3","journal-title":"3 Biotech"},{"key":"5395_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.176289","volume":"965","author":"M Afroz","year":"2024","unstructured":"Afroz M, Bhuia MS, Rahman MA, Hasan R, Islam T, Islam MR, Chowdhury R, Khan MA et al (2024) Anti-diarrheal effect of piperine possibly through the interaction with inflammation inducing enzymes: in vivo and in silico studies. Eur J Pharmacol 965:176289. https:\/\/doi.org\/10.1016\/j.ejphar.2023.176289","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"5395_CR27","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1002\/ptr.8139","volume":"38","author":"MH Bappi","year":"2024","unstructured":"Bappi MH, Mia MN, Ansari SA, Ansari IA, Prottay AAS, Akbor MS, El-Nashar HAS, El-Shazly M et al (2024) Quercetin increases the antidepressant-like effects of sclareol and antagonizes diazepam in thiopental sodium-induced sleeping mice: a possible GABAergic transmission intervention. Phytother Res 38(5):2198\u20132214. https:\/\/doi.org\/10.1002\/ptr.8139","journal-title":"Phytother Res"},{"key":"5395_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.imu.2022.100880","volume":"29","author":"TI Adelusi","year":"2022","unstructured":"Adelusi TI, Oyedele A-QK, Boyenle ID, Ogunlana AT, Adeyemi RO, Ukachi CD, Idris MO, Olaoba OT et al (2022) Molecular modeling in drug discovery. Inf Med Unlocked 29:100880","journal-title":"Inf Med Unlocked"},{"key":"5395_CR29","doi-asserted-by":"publisher","first-page":"100029","DOI":"10.1016\/j.pscia.2023.100029","volume":"2","author":"AAS Prottay","year":"2024","unstructured":"Prottay AAS, Bappi MH, Akbor MS, Asha AI, Bhuia MS, Shafin AA, Mia MN, Mubarak MS et al (2024) Sclareol exerts an anti-inflammatory effect, possibly through COXs inhibition pathway: in vivo and in silico studies. Pharm Sci Adv 2:100029","journal-title":"Pharm Sci Adv"},{"key":"5395_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/plants12244189","author":"R Chowdhury","year":"2023","unstructured":"Chowdhury R, Bhuia MS, Rakib AI, Hasan R, Coutinho HDM, Ara\u00fajo IM, de Menezes IRA, Islam MT (2023) Assessment of quercetin antiemetic properties: in vivo and in silico investigations on receptor binding affinity and synergistic effects. Plants. https:\/\/doi.org\/10.3390\/plants12244189","journal-title":"Plants"},{"issue":"19","key":"5395_CR31","doi-asserted-by":"publisher","first-page":"10070","DOI":"10.1080\/07391102.2022.2152871","volume":"41","author":"F En-Nahli","year":"2023","unstructured":"En-Nahli F, Baammi S, Hajji H, Alaqarbeh M, Lakhlifi T, Bouachrine M (2023) High-throughput virtual screening approach of natural compounds as target inhibitors of plasmepsin-II. J Biomol Struct Dyn 41(19):10070\u201310080. https:\/\/doi.org\/10.1080\/07391102.2022.2152871","journal-title":"J Biomol Struct Dyn"},{"key":"5395_CR32","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa239","author":"M Chen","year":"2021","unstructured":"Chen M, Feng Z, Wang S, Lin W, Xie XQ (2021) MCCS, a novel characterization method for protein-ligand complex. Brief Bioinform. https:\/\/doi.org\/10.1093\/bib\/bbaa239","journal-title":"Brief Bioinform"},{"issue":"2","key":"5395_CR33","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott O, Olson AJ (2010) AutoDock vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem 31(2):455\u2013461. https:\/\/doi.org\/10.1002\/jcc.21334","journal-title":"J Comput Chem"},{"key":"5395_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2023.101014","volume":"6","author":"MS Bhuia","year":"2023","unstructured":"Bhuia MS, Kamli H, Islam T, Sonia FA, Kazi MA, Siam MSH, Rahman N, Bappi MH et al (2023) Antiemetic activity of trans-ferulic acid possibly through muscarinic receptors interaction pathway: in vivo and in silico study. Results Chem 6:101014","journal-title":"Results Chem"},{"issue":"1","key":"5395_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-57173-0","volume":"14","author":"R Hasan","year":"2024","unstructured":"Hasan R, Alshammari A, Albekairi NA, Bhuia MS, Afroz M, Chowdhury R, Khan MA, Ansari SA et al (2024) Antiemetic activity of abietic acid possibly through the 5HT(3) and muscarinic receptors interaction pathways. Sci Rep 14(1):6642. https:\/\/doi.org\/10.1038\/s41598-024-57173-0","journal-title":"Sci Rep"},{"issue":"1","key":"5395_CR36","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00204-023-03632-y","volume":"98","author":"M Noga","year":"2024","unstructured":"Noga M, Michalska A, Jurowski K (2024) The prediction of acute toxicity (LD(50)) for organophosphorus-based chemical warfare agents (V-series) using toxicology in silico methods. Arch Toxicol 98(1):267\u2013275. https:\/\/doi.org\/10.1007\/s00204-023-03632-y","journal-title":"Arch Toxicol"},{"key":"5395_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2023.103044","volume":"55","author":"MN Mia","year":"2023","unstructured":"Mia MN, Smrity SZ, Bappi MH, Kamli H, Islam T, Prottay AAS, Akbor MS, Latif MA et al (2023) Anxiolytic-like effect of succinic acid: a possible GABAergic intervention. Food Biosci 55:103044","journal-title":"Food Biosci"},{"key":"5395_CR38","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.yrtph.2018.01.022","volume":"94","author":"J Strickland","year":"2018","unstructured":"Strickland J, Clippinger AJ, Brown J, Allen D, Jacobs A, Matheson J, Lowit A, Reinke EN et al (2018) Status of acute systemic toxicity testing requirements and data uses by U.S. regulatory agencies. Regul Toxicol Pharmacol 94:183\u2013196. https:\/\/doi.org\/10.1016\/j.yrtph.2018.01.022","journal-title":"Regul Toxicol Pharmacol"},{"key":"5395_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.comtox.2022.100237","author":"CM Zwickl","year":"2022","unstructured":"Zwickl CM, Graham J, Jolly R, Bassan A, Ahlberg E, Amberg A, Anger LT, Barton-Maclaren T et al (2022) Principles and procedures for assessment of acute toxicity incorporating in silico methods. Comput Toxicol. https:\/\/doi.org\/10.1016\/j.comtox.2022.100237","journal-title":"Comput Toxicol"},{"issue":"12","key":"5395_CR40","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1002\/da.20633","volume":"26","author":"MG Craske","year":"2009","unstructured":"Craske MG, Rauch SL, Ursano R, Prenoveau J, Pine DS, Zinbarg RE (2009) What is an anxiety disorder? Depress Anxiety 26(12):1066\u20131085. https:\/\/doi.org\/10.1002\/da.20633","journal-title":"Depress Anxiety"},{"issue":"2","key":"5395_CR41","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202301492","volume":"21","author":"MS Bhuia","year":"2024","unstructured":"Bhuia MS, Chowdhury R, Sonia FA, Biswas S, Ferdous J, El-Nashar HAS, El-Shazly M, Islam MT (2024) Efficacy of rotundic acid and its derivatives as promising natural anticancer triterpenoids: a literature-based study. Chem Biodivers 21(2):e202301492. https:\/\/doi.org\/10.1002\/cbdv.202301492","journal-title":"Chem Biodivers"},{"issue":"12","key":"5395_CR42","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202400874","volume":"21","author":"A Aktar","year":"2024","unstructured":"Aktar A, Bhuia S, Chowdhury R, Ferdous J, Khatun M, Hasan SA, Mia E, Hasan R et al (2024) An insight of plant source, toxicological profile, and pharmacological activities of iridoid loganic acid: a comprehensivereview. Chem Biodivers 21(12):e202400874. https:\/\/doi.org\/10.1002\/cbdv.202400874","journal-title":"Chem Biodivers"},{"key":"5395_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2023.103302","volume":"56","author":"MS Bhuia","year":"2023","unstructured":"Bhuia MS, Aktar MA, Chowdhury R, Ferdous J, Rahman MA, Al Hasan MS, Islam MT (2023) Therapeutic potentials of ononin with mechanistic insights: a comprehensive review. Food Biosci 56:103302","journal-title":"Food Biosci"},{"key":"5395_CR44","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.2147\/ndt.S535646","volume":"21","author":"Q Wang","year":"2025","unstructured":"Wang Q, Wang D, Lv Y, Li Q (2025) Traditional Chinese medicine in the management of anxiety disorders: a narrative review of theoretical foundations, clinical applications, and modern integrative approaches. Neuropsychiatr Dis Treat 21:1215\u20131233. https:\/\/doi.org\/10.2147\/ndt.S535646","journal-title":"Neuropsychiatr Dis Treat"},{"key":"5395_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26115417","author":"E Merkouris","year":"2025","unstructured":"Merkouris E, Brasinika A, Patsiavoura M, Siniosoglou C, Tsiptsios D, Triantafyllis AS, Mueller C, Mpikou I et al (2025) Molecular basis of anxiety: a comprehensive review of 2014\u20132024 clinical and preclinical studies. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms26115417","journal-title":"Int J Mol Sci"},{"issue":"5","key":"5395_CR46","doi-asserted-by":"publisher","first-page":"572","DOI":"10.2174\/1381612822666151125000550","volume":"22","author":"MH Baig","year":"2016","unstructured":"Baig MH, Ahmad K, Roy S, Ashraf JM, Adil M, Siddiqui MH, Khan S, Kamal MA et al (2016) Computer aided drug design: success and limitations. Curr Pharm Des 22(5):572\u2013581. https:\/\/doi.org\/10.2174\/1381612822666151125000550","journal-title":"Curr Pharm Des"},{"key":"5395_CR47","doi-asserted-by":"publisher","DOI":"10.1007\/s43450-025-00629-9","author":"D Bishwas","year":"2025","unstructured":"Bishwas D, Hasan R, Bhuia MS, Khatun T, Saleh Ni, Ansari SA, Ahammed NT, Mira MK et al (2025) Modulatory anxiolytic effect of aucubin on diazepam in Swiss albino mice: possible mechanisms through in vivo approach with receptor binding affinity. Rev Bras Farmacogn. https:\/\/doi.org\/10.1007\/s43450-025-00629-9","journal-title":"Rev Bras Farmacogn"},{"issue":"3","key":"5395_CR48","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1501240","volume":"2","author":"D Chen","year":"2016","unstructured":"Chen D, Oezguen N, Urvil P, Ferguson C, Dann SM, Savidge TC (2016) Regulation of protein-ligand binding affinity by hydrogen bond pairing. Sci Adv 2(3):e1501240. https:\/\/doi.org\/10.1126\/sciadv.1501240","journal-title":"Sci Adv"},{"issue":"2","key":"5395_CR49","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1002\/jps.21009","volume":"97","author":"A Ruiz-Garcia","year":"2008","unstructured":"Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG (2008) Pharmacokinetics in drug discovery. J Pharm Sci 97(2):654\u2013690. https:\/\/doi.org\/10.1002\/jps.21009","journal-title":"J Pharm Sci"},{"issue":"11","key":"5395_CR50","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.2174\/092986712799945021","volume":"19","author":"AT Garcia-Sosa","year":"2012","unstructured":"Garcia-Sosa AT, Maran U, Hetenyi C (2012) Molecular property filters describing pharmacokinetics and drug binding. Curr Med Chem 19(11):1646\u20131662. https:\/\/doi.org\/10.2174\/092986712799945021","journal-title":"Curr Med Chem"},{"issue":"1","key":"5395_CR51","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3390\/ijms13010427","volume":"13","author":"P Szyma\u0144ski","year":"2012","unstructured":"Szyma\u0144ski P, Markowicz M, Mikiciuk-Olasik E (2012) Adaptation of high-throughput screening in drug discovery-toxicological screening tests. Int J Mol Sci 13(1):427\u2013452. https:\/\/doi.org\/10.3390\/ijms13010427","journal-title":"Int J Mol Sci"},{"issue":"8","key":"5395_CR52","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/nrd2378","volume":"6","author":"JA Kramer","year":"2007","unstructured":"Kramer JA, Sagartz JE, Morris DL (2007) The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates. Nat Rev Drug Discov 6(8):636\u2013649. https:\/\/doi.org\/10.1038\/nrd2378","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"5395_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10937400490253229","volume":"7","author":"SM Choi","year":"2004","unstructured":"Choi SM, Yoo SD, Lee BM (2004) Toxicological characteristics of endocrine-disrupting chemicals: developmental toxicity, carcinogenicity, and mutagenicity. J Toxicol Environ Health B Crit Rev 7(1):1\u201324. https:\/\/doi.org\/10.1080\/10937400490253229","journal-title":"J Toxicol Environ Health B Crit Rev"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05395-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-05395-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05395-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T03:48:12Z","timestamp":1763610492000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-05395-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5395"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-05395-2","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"assertion":[{"value":"13 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical Trial Number"}}],"article-number":"104"}}