{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:12:07Z","timestamp":1792181527245,"version":"4.4.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Key Project of Medical Research Topics in Sichuan Province","award":["S23089"],"award-info":[{"award-number":["S23089"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-025-05458-4","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:37:20Z","timestamp":1763707040000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Verbascoside (VB) Inhibits Ischemic Stroke Progression via Suppression of Cell Damage and Ferroptosis By Targeting LCN2\/ALOX5\/SLC7A11\/GPX4 Expression"],"prefix":"10.1007","volume":"63","author":[{"given":"Cheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"5458_CR1","unstructured":"WHO. World Stroke Day 2021 [Available from:\u00a0https:\/\/www.who.int\/southeastasia\/news\/detail\/28-10-2021-world-stroke-day#:~:text=Globally%2C%20stroke%20is%20the%20second%20leading%20cause%20of,are%20in%20danger%20of%20stroke%20in%20their%20lifetime. Accessed on: March 27, 2025."},{"key":"5458_CR2","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41572-019-0118-8","volume":"5","author":"BC Campbell","year":"2019","unstructured":"Campbell BC, De Silva DA, Macleod MR, Coutts SB, Schwamm LH, Davis SM, Donnan GA (2019) Ischaemic stroke. Nat Rev Dis Primers 5:70","journal-title":"Nat Rev Dis Primers"},{"key":"5458_CR3","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1007\/s00415-025-13082-4","volume":"272","author":"M He","year":"2025","unstructured":"He M, Zhang S, Liu X, He Y, Gu X, Yue C (2025) Global, regional, and national epidemiology of ischemic stroke in young adults, 1990\u20132021. J Neurol 272:354","journal-title":"J Neurol"},{"key":"5458_CR4","doi-asserted-by":"publisher","first-page":"845","DOI":"10.2174\/1570180819666220512170331","volume":"20","author":"SA Kumar","year":"2023","unstructured":"Kumar SA, Dahiya K, Kumar G (2023) Identification of Withanolide G as a Potential Inhibitor of Rho-associated Kinase-2 Catalytic Domain to Confer Neuroprotection in Ischemic Stroke. Lett Drug Des Discovery 20:845\u2013853","journal-title":"Lett Drug Des Discovery"},{"key":"5458_CR5","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1161\/STROKEAHA.122.040073","volume":"54","author":"L Pu","year":"2023","unstructured":"Pu L, Wang L, Zhang R (2023) Projected global trends in ischemic stroke incidence, deaths and disability-adjusted life years from 2020 to 2030. Stroke 54:1330\u20131339","journal-title":"Stroke"},{"key":"5458_CR6","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.2174\/0115701808332742241126105407","volume":"21","author":"A Samira","year":"2024","unstructured":"Samira A, Ameri M, Anjomshoa M (2024) Cornus mas (Cornelian Cherry) Exerts Neuroprotective Effects on Cerebral Ischemia\/Reperfusion Injury via Anti-inflammatory and Antioxidant Properties. Lett Drug Des Discovery 21:4455\u20134464","journal-title":"Lett Drug Des Discovery"},{"issue":"2","key":"5458_CR7","first-page":"1","volume":"49","author":"Y Zhao","year":"2022","unstructured":"Zhao Y, Zhang X, Chen X, Wei Y (2022) Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review). Int J Mol Med 49(2):1\u20139","journal-title":"Int J Mol Med"},{"key":"5458_CR8","doi-asserted-by":"publisher","first-page":"e272","DOI":"10.1161\/STR.0000000000000430","volume":"54","author":"N El Husseini","year":"2023","unstructured":"El Husseini N, Katzan IL, Rost NS, Blake ML, Byun E, Pendlebury ST, Aparicio HJ, Marquine MJ et al (2023) Cognitive Impairment After Ischemic and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association\/American Stroke Association. Stroke 54:e272\u2013e291","journal-title":"Stroke"},{"key":"5458_CR9","doi-asserted-by":"publisher","first-page":"6057","DOI":"10.1097\/MS9.0000000000001441","volume":"85","author":"C Elendu","year":"2023","unstructured":"Elendu C, Amaechi DC, Elendu TC, Ibhiedu JO, Egbunu EO, Ndam AR, Ogala F, Ologunde T et al (2023) Stroke and cognitive impairment: understanding the connection and managing symptoms. Ann Med Surg (Lond) 85:6057\u20136066","journal-title":"Ann Med Surg (Lond)"},{"key":"5458_CR10","doi-asserted-by":"publisher","first-page":"748949","DOI":"10.3389\/fmedt.2022.748949","volume":"4","author":"S Patil","year":"2022","unstructured":"Patil S, Rossi R, Jabrah D, Doyle K (2022) Detection, diagnosis and treatment of acute ischemic stroke: current and future perspectives. Front Med Technol 4:748949","journal-title":"Front Med Technol"},{"key":"5458_CR11","doi-asserted-by":"publisher","first-page":"100592","DOI":"10.1016\/j.xplc.2023.100592","volume":"4","author":"Y Yang","year":"2023","unstructured":"Yang Y, Daoyi Xi, Yanan Wu, Tao L (2023) Complete biosynthesis of the phenylethanoid glycoside verbascoside. Plant Commun 4:100592","journal-title":"Plant Commun"},{"key":"5458_CR12","doi-asserted-by":"publisher","first-page":"155027","DOI":"10.1016\/j.phymed.2023.155027","volume":"120","author":"YZ Yi Zhao","year":"2023","unstructured":"Yi Zhao YZ, Wang Sijia WS, Pan Jin PJ, Ma Ke MK (2023) Verbascoside: a neuroprotective phenylethanoid glycosides with anti-depressive properties. Phytomedicine 120:155027","journal-title":"Phytomedicine"},{"key":"5458_CR13","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.biotechadv.2014.07.001","volume":"32","author":"K Alipieva","year":"2014","unstructured":"Alipieva K, Liudmila K, Ilkay O, Milen G (2014) Verbascoside \u2013 A review of its occurrence, (bio)synthesis and pharmacological significance. Biotechnol Adv 32:1065\u20131076","journal-title":"Biotechnol Adv"},{"key":"5458_CR14","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1038\/s41598-024-52511-8","volume":"14","author":"M Kanlayavattanakul","year":"2024","unstructured":"Kanlayavattanakul M, Mattaka K, Nattaya L (2024) Wound healing and photoprotection properties of Acanthus ebracteatus Vahl. extracts standardized in verbascoside. Sci Rep 14:1904","journal-title":"Sci Rep"},{"key":"5458_CR15","first-page":"1017","volume":"57","author":"Y-C Zhang","year":"2022","unstructured":"Zhang Y-C, Zhang X-W, Wang L-C, Tu P-F, Wang T-W, Zeng K-W (2022) Protective effects and pharmacophore discovery of verbascoside against oxygen-glucose deprivation\/reperfusion-induced neuronal cells injury. Yaoxue Xuebao 57:1017\u20131023","journal-title":"Yaoxue Xuebao"},{"key":"5458_CR16","doi-asserted-by":"publisher","first-page":"134415","DOI":"10.1016\/j.neulet.2019.134415","volume":"711","author":"W Wei","year":"2019","unstructured":"Wei W, Lu M, Lan X, Liu N, Wang H, Du J, Sun T, Li Y et al (2019) Neuroprotective effect of Verbascoside on hypoxic-ischemic brain damage in neonatal rat. Neurosci Lett 711:134415","journal-title":"Neurosci Lett"},{"key":"5458_CR17","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.bbrc.2019.09.057","volume":"519","author":"L Xue","year":"2019","unstructured":"Xue L, Xiong Y, Zhou J, Yang F, Peng J, Chen L, Zhong W (2019) Verbascoside attenuates acute inflammatory injury in experimental cerebral hemorrhage by suppressing TLR4. Biochem Bioph Res Co 519:721\u2013726","journal-title":"Biochem Bioph Res Co"},{"key":"5458_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1229885","volume":"14","author":"SK Schr\u00f6der","year":"2023","unstructured":"Schr\u00f6der SK, Gasterich N, Weiskirchen S, Weiskirchen R (2023) Lipocalin 2 receptors: facts, fictions, and myths. Front Immunol 14:1229885","journal-title":"Front Immunol"},{"key":"5458_CR19","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3389\/fphys.2016.00430","volume":"7","author":"A Asimakopoulou","year":"2016","unstructured":"Asimakopoulou A, Weiskirchen S, Weiskirchen R (2016) Lipocalin 2 (LCN2) expression in hepatic malfunction and therapy. Front Physiol 7:430","journal-title":"Front Physiol"},{"key":"5458_CR20","doi-asserted-by":"publisher","first-page":"101414","DOI":"10.1016\/j.arr.2021.101414","volume":"70","author":"DW Dekens","year":"2021","unstructured":"Dekens DW, Eisel ULM, Gouweleeuw L, Schoemaker RG, De Deyn PP, Naud\u00e9 PJW (2021) Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases. Ageing Res Rev 70:101414","journal-title":"Ageing Res Rev"},{"key":"5458_CR21","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1038\/s12276-023-01098-7","volume":"55","author":"B-K Jung","year":"2023","unstructured":"Jung B-K, Kwon-Yul R (2023) Lipocalin-2: a therapeutic target to overcome neurodegenerative diseases by regulating reactive astrogliosis. Exp Mol Med 55:2138\u20132146","journal-title":"Exp Mol Med"},{"key":"5458_CR22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.neubiorev.2014.12.006","volume":"49","author":"MK Jha","year":"2015","unstructured":"Jha MK, Lee S, Park DH, Kook H, Park KG, Lee IK, Suk K (2015) Diverse functional roles of lipocalin-2 in the central nervous system. Neurosci Biobehav Rev 49:135\u2013156","journal-title":"Neurosci Biobehav Rev"},{"key":"5458_CR23","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.neuroscience.2023.02.011","volume":"515","author":"W Zhang","year":"2023","unstructured":"Zhang W, Chen S, Zhuang X (2023) Research progress on Lipocalin-2 in diabetic encephalopathy. Neuroscience 515:74\u201382","journal-title":"Neuroscience"},{"key":"5458_CR24","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1111\/cns.13653","volume":"27","author":"D Lim","year":"2021","unstructured":"Lim D, Jeong JH, Song J (2021) Lipocalin 2 regulates iron homeostasis, neuroinflammation, and insulin resistance in the brains of patients with dementia: evidence from the current literature. CNS Neurosci Ther 27:883\u2013894","journal-title":"CNS Neurosci Ther"},{"key":"5458_CR25","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s43018-023-00519-w","volume":"4","author":"O Adler","year":"2023","unstructured":"Adler O, Yael Z, Noam C, Raquel B, Hila D, Lea M, Yeela S, Tamar S et al (2023) Reciprocal interactions between innate immune cells and astrocytes facilitate neuroinflammation and brain metastasis via lipocalin-2. Nature Cancer 4:401\u2013418","journal-title":"Nature Cancer"},{"key":"5458_CR26","doi-asserted-by":"publisher","first-page":"114885","DOI":"10.1016\/j.expneurol.2024.114885","volume":"379","author":"K Laohavisudhi","year":"2024","unstructured":"Laohavisudhi K, Sirawit S, Tanawat A, Borwon W, Nipon C, Siriporn C (2024) Mechanistic insights into Lipocalin-2 in ischemic stroke and hemorrhagic brain injury: Integrating animal and clinical studies. Exp Neurol 379:114885","journal-title":"Exp Neurol"},{"key":"5458_CR27","doi-asserted-by":"publisher","first-page":"167435","DOI":"10.1016\/j.bbadis.2024.167435","volume":"1870","author":"F Xiaowei","year":"2024","unstructured":"Xiaowei F, Dou Y, Yang Y, Zheng B, Luo P, Dai S, Zhang J, Peng K et al (2024) Lipocalin-2 inhibition alleviates neural injury by microglia ferroptosis suppression after experimental intracerebral hemorrhage in mice via enhancing ferritin light chain expression. BBA-Mol Basis Dis 1870:167435","journal-title":"BBA-Mol Basis Dis"},{"key":"5458_CR28","doi-asserted-by":"publisher","first-page":"150452","DOI":"10.1016\/j.bbrc.2024.150452","volume":"733","author":"W Si","year":"2024","unstructured":"Si W, Ruijia Y, Bin S, Jing L, Guanhua Hu (2024) The role of LCN2 in exacerbating ferroptosis levels in acute ischemic stroke injury. Biocheml Bioph Res Co 733:150452","journal-title":"Biocheml Bioph Res Co"},{"key":"5458_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106779","volume":"193","author":"K Li","year":"2023","unstructured":"Li K, Meng W, Zi-Han H, Min W, Wan-Yang S, Hiroshi K, Rui-Ting H, Rong W et al (2023) ALOX5 inhibition protects against dopaminergic neurons undergoing ferroptosis. Pharmacol Res 193:106779","journal-title":"Pharmacol Res"},{"key":"5458_CR30","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1038\/s41419-023-06333-7","volume":"14","author":"T Liu","year":"2023","unstructured":"Liu T, Xu X, Li J, Bai M, Zhu W, Liu Y, Liu S, Zhao Z et al (2023) Alox5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape. Cell Death Dis 14:800","journal-title":"Cell Death Dis"},{"key":"5458_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115554","volume":"212","author":"M Wang","year":"2023","unstructured":"Wang M, Guang Z, Bingrui X, Xiaobin Z, Jia G, Danyang C, Shanshan Z, Min L et al (2023) ALOX5 promotes autophagy-dependent ferroptosis by activating the AMPK\/mTOR pathway in melanoma. Biochem Pharmacol 212:115554","journal-title":"Biochem Pharmacol"},{"key":"5458_CR32","doi-asserted-by":"publisher","first-page":"110505","DOI":"10.1016\/j.intimp.2023.110505","volume":"121","author":"WM Hu","year":"2023","unstructured":"Hu WM, Liu SQ, Zhu KF, Li W, Yang ZJ, Yang Q, Zhu ZC, Chang J (2023) The ALOX5 inhibitor zileuton regulates tumor-associated macrophage M2 polarization by JAK\/STAT and inhibits pancreatic cancer invasion and metastasis. Int Immunopharmacol 121:110505","journal-title":"Int Immunopharmacol"},{"key":"5458_CR33","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1101\/gad.350211.122","volume":"37","author":"S Song","year":"2023","unstructured":"Song S, Su Z, Kon N, Chu B, Li H, Jiang X, Luo J, Stockwell BR, Gu W (2023) ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington\u2019s disease. Genes Dev 37:204\u2013217","journal-title":"Genes Dev"},{"key":"5458_CR34","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1159\/000482023","volume":"43","author":"D Liu","year":"2017","unstructured":"Liu D, Liu L, Song Z, Hu Z, Liu J, Hou D (2017) Genetic variations of oxidative stress related genes ALOX5, ALOX5AP and MPO modulate ischemic stroke susceptibility through main effects and epistatic interactions in a Chinese population. Cell Physiol Biochem 43:1588\u20131602","journal-title":"Cell Physiol Biochem"},{"key":"5458_CR35","doi-asserted-by":"publisher","first-page":"435","DOI":"10.18388\/abp.2015_1039","volume":"62","author":"A Niewiarowska-Sendo","year":"2015","unstructured":"Niewiarowska-Sendo A, Patrzalek K, Kozik A, Guevara-Lora I (2015) The effect of differentiation agents on inflammatory and oxidative responses of the human neuroblastoma cell line SK-N-SH. Acta Biochim Pol 62:435\u2013443","journal-title":"Acta Biochim Pol"},{"key":"5458_CR36","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060\u20131072","journal-title":"Cell"},{"key":"5458_CR37","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","volume":"97","author":"B Wang","year":"2023","unstructured":"Wang B, Yue W, Zhang Jing Hu, Chang JJ, Yiming Li, ZhiYong P (2023) ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis. Arch Toxicol 97:1439\u20131451","journal-title":"Arch Toxicol"},{"key":"5458_CR38","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","volume":"171","author":"BR Stockwell","year":"2017","unstructured":"Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gasc\u00f3n S et al (2017) Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell 171:273\u2013285","journal-title":"Cell"},{"key":"5458_CR39","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/s41419-018-0794-4","volume":"9","author":"Y Sun","year":"2018","unstructured":"Sun Y, Yingfeng Z, Chunxiao W, Yizhi L (2018) Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells. Cell Death Dis 9:753","journal-title":"Cell Death Dis"},{"key":"5458_CR40","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","volume":"16","author":"JP Friedmann Angeli","year":"2014","unstructured":"Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M et al (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol 16:1180\u20131191","journal-title":"Nat Cell Biol"},{"issue":"47","key":"5458_CR41","first-page":"2423","volume":"6","author":"O Engel","year":"2011","unstructured":"Engel O, Kolodziej S, Dirnagl U, Prinz V (2011) Modeling stroke in mice - middle cerebral artery occlusion with the filament model. J Vis Exp 6(47):2423","journal-title":"J Vis Exp"},{"key":"5458_CR42","doi-asserted-by":"publisher","first-page":"e036142","DOI":"10.1161\/JAHA.124.036142","volume":"13","author":"Y Cheng","year":"2024","unstructured":"Cheng Y, Yongqi L, Hujuan S, Mingmei C, Baoliang Z, Xiaofeng L, Chuan S, Yanzhong W et al (2024) Projections of the stroke burden at the global, regional, and national levels up to 2050 based on the Global Burden of Disease Study 2021. J Am Heart Assoc 13:e036142","journal-title":"J Am Heart Assoc"},{"key":"5458_CR43","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1177\/17474930241308142","volume":"20","author":"VL Feigin","year":"2025","unstructured":"Feigin VL, Brainin M (2025) World stroke organization: global stroke fact sheet 2025. Int J Stroke 20:132\u2013144","journal-title":"Int J Stroke"},{"key":"5458_CR44","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1002\/med.22009","volume":"44","author":"J Jia","year":"2024","unstructured":"Jia J, Jiao W, Wang G, Wu J, Huang Z, Zhang Y (2024) Drugs\/agents for the treatment of ischemic stroke: advances and perspectives. Med Res Rev 44:975\u20131012","journal-title":"Med Res Rev"},{"key":"5458_CR45","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1007\/s10787-024-01555-3","volume":"32","author":"R Saha","year":"2024","unstructured":"Saha R, Ankit M, Ritika B, Biswatrish S (2024) Verbascoside: comprehensive review of a phenylethanoid macromolecule and its journey from nature to bench. Inflammopharmacology 32:2729\u20132751","journal-title":"Inflammopharmacology"},{"key":"5458_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/CAD.0000000000000818","volume":"31","author":"O Nigro","year":"2020","unstructured":"Nigro O, Tuzi A, Tartaro T, Giaquinto A, Vallini I, Pinotti G (2020) Biological effects of verbascoside and its anti-inflammatory activity on oral mucositis: a review of the literature. Anticancer Drugs 31:1\u20135","journal-title":"Anticancer Drugs"},{"key":"5458_CR47","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s40360-021-00540-8","volume":"22","author":"A Daneshforouz","year":"2021","unstructured":"Daneshforouz A, Nazemi S, Gholami O, Kafami M, Amin B (2021) The cytotoxicity and apoptotic effects of verbascoside on breast cancer 4T1 cell line. BMC Pharmacol Toxicol 22:72","journal-title":"BMC Pharmacol Toxicol"},{"key":"5458_CR48","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.1016\/j.fshw.2023.03.035","volume":"12","author":"P Lei","year":"2023","unstructured":"Lei P, Jialin L\u00fc, Tie Y, Peng Z, Xin C, Yuefei W, Miaomiao J (2023) Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolism. Food Sci Hum Well 12:2314\u20132323","journal-title":"Food Sci Hum Well"},{"key":"5458_CR49","doi-asserted-by":"publisher","first-page":"8755","DOI":"10.3390\/cimb45110550","volume":"45","author":"SP Akyer","year":"2023","unstructured":"Akyer SP, Karagur ER, Ata MT, Toprak EK, Donmez AC (2023) Verbascoside Inhibits\/Repairs the Damage of LPS-Induced Inflammation by Regulating Apoptosis, Oxidative Stress, and Bone Remodeling. Curr Issues Mol Biol 45:8755\u20138766","journal-title":"Curr Issues Mol Biol"},{"key":"5458_CR50","first-page":"367","volume":"46","author":"F Cheng","year":"2025","unstructured":"Cheng F, Huang W, Du M (2025) Verbascoside inhibits the activation of NLRP3 inflammasome and improves BV-2 cell inflammatory damage. Sci Technol Food Ind 46:367\u2013373","journal-title":"Sci Technol Food Ind"},{"key":"5458_CR51","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.fct.2018.06.018","volume":"119","author":"M Li","year":"2018","unstructured":"Li M, Zhou Fei Xu, Tao SH, Baiyi Lu (2018) Acteoside protects against 6-OHDA-induced dopaminergic neuron damage via Nrf2-ARE signaling pathway. Food Chem Toxicol 119:6\u201313","journal-title":"Food Chem Toxicol"},{"key":"5458_CR52","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/978-1-4939-7526-6_18","volume":"1717","author":"MG Ryou","year":"2018","unstructured":"Ryou MG, Mallet RT (2018) An In Vitro Oxygen-Glucose Deprivation Model for Studying Ischemia-Reperfusion Injury of Neuronal Cells. Methods Mol Biol 1717:229\u2013235","journal-title":"Methods Mol Biol"},{"key":"5458_CR53","doi-asserted-by":"publisher","first-page":"106044","DOI":"10.1016\/j.nbd.2023.106044","volume":"179","author":"R-Y Zhao","year":"2023","unstructured":"Zhao R-Y, Peng-Ju W, Xin S, Dian-Hui Z, Qian-Yan He, Jie L, Jun-Lei C, Yi Y et al (2023) Role of lipocalin 2 in stroke. Neurobiol Dis 179:106044","journal-title":"Neurobiol Dis"},{"key":"5458_CR54","doi-asserted-by":"publisher","first-page":"123102","DOI":"10.1016\/j.biomaterials.2025.123102","volume":"317","author":"R Xiao","year":"2025","unstructured":"Xiao R, Pan J, Yang M, Liu H, Zhang A, Guo X, Zhou S (2025) Regulating astrocyte phenotype by Lcn2 inhibition toward ischemic stroke therapy. Biomaterials 317:123102","journal-title":"Biomaterials"},{"key":"5458_CR55","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/kjm2.12806","volume":"40","author":"T Yao","year":"2024","unstructured":"Yao T, Yao YY, Wang JZ, Jiang SM, Li LJ (2024) Magnolin alleviated DSS-induced colitis by inhibiting ALOX5-mediated ferroptosis. Kaohsiung J Med Sci 40:360\u2013373","journal-title":"Kaohsiung J Med Sci"},{"key":"5458_CR56","doi-asserted-by":"publisher","first-page":"7147","DOI":"10.1038\/s41467-021-27414-1","volume":"12","author":"JL Parker","year":"2021","unstructured":"Parker JL, Justin C. D, Kolokouris D, Kuteyi G, Biggin PC, Lea SM, Newstead S (2021) Molecular basis for redox control by the human cystine\/glutamate antiporter system xc\u2212. Nat Commun 12:7147","journal-title":"Nat Commun"},{"key":"5458_CR57","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3892\/ol.2021.13165","volume":"23","author":"X Tang","year":"2022","unstructured":"Tang X, Chen W, Liu H, Liu N, Chen D, Tian D, Wang J (2022) Research progress on SLC7A11 in the regulation of cystine\/cysteine metabolism in tumors. Oncol Lett 23:47","journal-title":"Oncol Lett"},{"key":"5458_CR58","doi-asserted-by":"publisher","first-page":"3673","DOI":"10.1038\/s41467-023-39401-9","volume":"14","author":"Y Yan","year":"2023","unstructured":"Yan Y, Teng H, Hang Q, Kondiparthi L, Lei G, Horbath A, Liu X, Mao C et al (2023) SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells. Nat Commun 14:3673","journal-title":"Nat Commun"},{"key":"5458_CR59","doi-asserted-by":"publisher","first-page":"e1800311","DOI":"10.1002\/pmic.201800311","volume":"19","author":"GC Forcina","year":"2019","unstructured":"Forcina GC, Dixon SJ (2019) GPX4 at the crossroads of lipid homeostasis and ferroptosis. Proteomics 19:e1800311","journal-title":"Proteomics"},{"key":"5458_CR60","doi-asserted-by":"publisher","first-page":"188890","DOI":"10.1016\/j.bbcan.2023.188890","volume":"1878","author":"Y Liu","year":"2023","unstructured":"Liu Y, Wan Y, Jiang Y, Zhang L, Cheng W (2023) GPX4: the hub of lipid oxidation, ferroptosis, disease and treatment. Biochim Biophys Acta Rev Cancer 1878:188890","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"5458_CR61","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/s41420-022-01212-0","volume":"8","author":"T Ma","year":"2022","unstructured":"Ma T, Du J, Zhang Y, Wang Y, Wang B, Zhang T (2022) GPX4-independent ferroptosis\u2014a new strategy in disease\u2019s therapy. Cell Death Discov 8:434","journal-title":"Cell Death Discov"},{"key":"5458_CR62","doi-asserted-by":"publisher","first-page":"e995047","DOI":"10.4161\/23723556.2014.995047","volume":"2","author":"M Conrad","year":"2015","unstructured":"Conrad M, Friedmann Angeli JP (2015) Glutathione peroxidase 4 (Gpx4) and ferroptosis: what\u2019s so special about it? Mol Cell Oncol 2:e995047","journal-title":"Mol Cell Oncol"},{"key":"5458_CR63","doi-asserted-by":"publisher","first-page":"116029","DOI":"10.1016\/j.jep.2022.116029","volume":"303","author":"Q Li","year":"2023","unstructured":"Li Q, Peng F, Yan X, Chen Y, Zhou J, Wu S, Jiang W, Jin X et al (2023) Inhibition of SLC7A11-GPX4 signal pathway is involved in aconitine-induced ferroptosis in vivo and in vitro. J Ethnopharmacol 303:116029","journal-title":"J Ethnopharmacol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05458-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-05458-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05458-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T08:03:54Z","timestamp":1763712234000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-05458-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5458"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-05458-4","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,21]]},"assertion":[{"value":"15 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present study was approved by the ethical review committee of The Zigong Third People\u2019s Hospital. Written informed consent was obtained from all enrolled patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Patients agree to participate in this work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"116"}}