{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:30:14Z","timestamp":1781332214878,"version":"3.54.1"},"reference-count":166,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-025-05632-8","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T07:49:43Z","timestamp":1767685783000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeted Drug Delivery in Animal Models of Demyelination: The Role of Plant-Based Nanoparticles with a Focus on Multiple Sclerosis"],"prefix":"10.1007","volume":"63","author":[{"given":"Amirali","family":"Ebrahimbabaei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Osanloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ghanbariasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6257-9180","authenticated-orcid":false,"given":"Manzarbanoo","family":"Shojaeifard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"issue":"8","key":"5632_CR1","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.nrleng.2022.02.004","volume":"39","author":"FG L\u00f3pez","year":"2024","unstructured":"L\u00f3pez FG, Garc\u00eda-Merino A, Alcalde-Cabero E, de Pedro-Cuesta J (2024) Incidence and prevalence of multiple sclerosis in Spain: a systematic review. Neurolog\u00eda (English Edition) 39(8):639\u2013650","journal-title":"Neurolog\u00eda (English Edition)"},{"key":"5632_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.100977","author":"E Portaccio","year":"2024","unstructured":"Portaccio E, Magyari M, Havrdova EK, Ruet A, Brochet B, Scalfari A, Di Filippo M, Tur C et al (2024) Multiple sclerosis: emerging epidemiological trends and redefining the clinical course. The Lancet Regional Health - Europe. https:\/\/doi.org\/10.1016\/j.lanepe.2024.100977","journal-title":"The Lancet Regional Health - Europe"},{"issue":"14","key":"5632_CR3","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1177\/1352458520970841","volume":"26","author":"C Walton","year":"2020","unstructured":"Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, Robertson N, La Rocca N, et al. (2020) Rising prevalence of multiple sclerosis worldwide: insights from the Atlas of MS. Mult Scler J 26(14):1816\u20131821","journal-title":"Mult Scler J"},{"issue":"2","key":"5632_CR4","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1136\/jnnp.2008.171132","volume":"9","author":"A Coles","year":"2009","unstructured":"Coles A (2009) Multiple sclerosis: the bare essentials. Pract Neurol 9(2):118\u2013126","journal-title":"Pract Neurol"},{"issue":"3","key":"5632_CR5","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028936","volume":"8","author":"H Lassmann","year":"2018","unstructured":"Lassmann H (2018) Multiple sclerosis pathology. Cold Spring Harb Perspect Med 8(3):a028936","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"1","key":"5632_CR6","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1146\/annurev.neuro.30.051606.094313","volume":"31","author":"BD Trapp","year":"2008","unstructured":"Trapp BD, Nave K-A (2008) Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 31(1):247\u2013269","journal-title":"Annu Rev Neurosci"},{"issue":"11","key":"5632_CR7","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1136\/jcp.2005.031195","volume":"59","author":"S Love","year":"2006","unstructured":"Love S (2006) Demyelinating diseases. J Clin Pathol 59(11):1151\u20131159","journal-title":"J Clin Pathol"},{"issue":"1","key":"5632_CR8","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1750-3639.2001.tb00385.x","volume":"11","author":"GK Matsushima","year":"2001","unstructured":"Matsushima GK, Morell P (2001) The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system. Brain Pathol 11(1):107\u2013116","journal-title":"Brain Pathol"},{"issue":"1","key":"5632_CR9","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/ana.20913","volume":"60","author":"L Steinman","year":"2006","unstructured":"Steinman L, Zamvil SS (2006) How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann Neurol 60(1):12\u201321","journal-title":"Ann Neurol"},{"issue":"1","key":"5632_CR10","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1146\/annurev-pathol-011811-132443","volume":"7","author":"BFG Popescu","year":"2012","unstructured":"Popescu BFG, Lucchinetti CF (2012) Pathology of demyelinating diseases. Annu Rev Pathol Mech Dis 7(1):185\u2013217","journal-title":"Annu Rev Pathol Mech Dis"},{"issue":"8","key":"5632_CR11","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1001\/jama.2020.26858","volume":"325","author":"MP McGinley","year":"2021","unstructured":"McGinley MP, Goldschmidt CH, Rae-Grant AD (2021) Diagnosis and treatment of multiple sclerosis: a review. JAMA 325(8):765\u2013779","journal-title":"JAMA"},{"issue":"927","key":"5632_CR12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1136\/pmj.79.927.11","volume":"79","author":"RK Garg","year":"2003","unstructured":"Garg RK (2003) Acute disseminated encephalomyelitis. Postgrad Med J 79(927):11\u201317","journal-title":"Postgrad Med J"},{"issue":"7","key":"5632_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1316","volume":"10","author":"JA Lopez","year":"2021","unstructured":"Lopez JA, Denkova M, Ramanathan S, Dale RC, Brilot F (2021) Pathogenesis of autoimmune demyelination: from multiple sclerosis to neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody\u2010associated disease. Clin Transl Immunol 10(7):e1316","journal-title":"Clin Transl Immunol"},{"issue":"1","key":"5632_CR14","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S1474-4422(13)70259-X","volume":"13","author":"AT Toosy","year":"2014","unstructured":"Toosy AT, Mason DF, Miller DH (2014) Optic neuritis. Lancet Neurol 13(1):83\u201399","journal-title":"Lancet Neurol"},{"issue":"16_suppl_2","key":"5632_CR15","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.1212\/01.wnl.0000259404.51352.7f","volume":"68","author":"S Tenembaum","year":"2007","unstructured":"Tenembaum S, Chitnis T, Ness J, Hahn JS (2007) Acute disseminated encephalomyelitis. Neurology 68(16_suppl_2):S23\u2013S36","journal-title":"Neurology"},{"issue":"7","key":"5632_CR16","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1007\/s00415-023-11634-0","volume":"270","author":"S Jarius","year":"2023","unstructured":"Jarius S, Aktas O, Ayzenberg I, Bellmann-Strobl J, Berthele A, Giglhuber K, H\u00e4u\u00dfler V, Havla J et al (2023) Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD)\u2013revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part I: diagnosis and differential diagnosis. J Neurol 270(7):3341\u20133368","journal-title":"J Neurol"},{"issue":"12","key":"5632_CR17","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1016\/j.clinthera.2014.08.006","volume":"36","author":"MD Carrithers","year":"2014","unstructured":"Carrithers MD (2014) Update on disease-modifying treatments for multiple sclerosis. Clin Ther 36(12):1938\u20131945","journal-title":"Clin Ther"},{"issue":"1","key":"5632_CR18","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020412","volume":"7","author":"R Daneman","year":"2015","unstructured":"Daneman R, Prat A (2015) The blood\u2013brain barrier. Cold Spring Harb Perspect Biol 7(1):a020412","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"11","key":"5632_CR19","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1038\/jcbfm.2012.126","volume":"32","author":"WM Pardridge","year":"2012","unstructured":"Pardridge WM (2012) Drug transport across the blood\u2013brain barrier. J Cereb Blood Flow Metab 32(11):1959\u20131972","journal-title":"J Cereb Blood Flow Metab"},{"issue":"11","key":"5632_CR20","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/nrd3248","volume":"9","author":"V Brinkmann","year":"2010","unstructured":"Brinkmann V, Billich A, Baumruker T, Heining P, Schmouder R, Francis G, Aradhye S, Burtin P (2010) Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat Rev Drug Discov 9(11):883\u2013897","journal-title":"Nat Rev Drug Discov"},{"issue":"12","key":"5632_CR21","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/nrn.2017.136","volume":"18","author":"RJ Franklin","year":"2017","unstructured":"Franklin RJ, Ffrench-Constant C (2017) Regenerating CNS myelin\u2014from mechanisms to experimental medicines. Nat Rev Neurosci 18(12):753\u2013769","journal-title":"Nat Rev Neurosci"},{"issue":"12","key":"5632_CR22","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1177\/0269215513488607","volume":"27","author":"N Draulans","year":"2013","unstructured":"Draulans N, Vermeersch K, Degraeuwe B, Meurrens T, Peers K, Nuttin B, Kiekens C (2013) Intrathecal baclofen in multiple sclerosis and spinal cord injury: complications and long-term dosage evolution. Clin Rehabil 27(12):1137\u20131143","journal-title":"Clin Rehabil"},{"key":"5632_CR23","doi-asserted-by":"publisher","first-page":"175628641989236","DOI":"10.1177\/1756286419892360","volume":"12","author":"JW Stark","year":"2019","unstructured":"Stark JW, Josephs L, Dulak D, Clague M, Sadiq SA (2019) Safety of long-term intrathecal methotrexate in progressive forms of MS. Ther Adv Neurol Disord 12:1756286419892360","journal-title":"Ther Adv Neurol Disord"},{"key":"5632_CR24","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.mattod.2020.02.001","volume":"37","author":"S Ding","year":"2020","unstructured":"Ding S, Khan AI, Cai X, Song Y, Lyu Z, Du D, Dutta P, Lin Y (2020) Overcoming blood\u2013brain barrier transport: advances in nanoparticle-based drug delivery strategies. Mater Today 37:112\u2013125","journal-title":"Mater Today"},{"key":"5632_CR25","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.addr.2013.08.008","volume":"71","author":"J Kreuter","year":"2014","unstructured":"Kreuter J (2014) Drug delivery to the central nervous system by polymeric nanoparticles: what do we know? Adv Drug Deliv Rev 71:2\u201314","journal-title":"Adv Drug Deliv Rev"},{"key":"5632_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119987","volume":"245","author":"L Lu","year":"2020","unstructured":"Lu L, Qi S, Chen Y, Luo H, Huang S, Yu X, Luo Q, Zhang Z (2020) Targeted immunomodulation of inflammatory monocytes across the blood-brain barrier by curcumin-loaded nanoparticles delays the progression of experimental autoimmune encephalomyelitis. Biomaterials 245:119987","journal-title":"Biomaterials"},{"key":"5632_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.solidstatesciences.2024.107555","volume":"153","author":"N Pruthviraj","year":"2024","unstructured":"Pruthviraj N, Geetha K, Kumar GA, Shruthi D, Shankar A, Prakash S, Sridhara S, Raghu AV (2024) Evaluation of shelf life of nanoparticles synthesized with different methods and its influence on root and shoot morphology of sunflower. Solid State Sci 153:107555","journal-title":"Solid State Sci"},{"issue":"9","key":"5632_CR28","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/iub.2045","volume":"71","author":"T Aghaie","year":"2019","unstructured":"Aghaie T, Jazayeri MH, Avan A, Anissian A, Salari AA (2019) Gold nanoparticles and polyethylene glycol alleviate clinical symptoms and alter cytokine secretion in a mouse model of experimental autoimmune encephalomyelitis. IUBMB Life 71(9):1313\u20131321","journal-title":"IUBMB Life"},{"key":"5632_CR29","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S442520","author":"P Mohapatra","year":"2024","unstructured":"Mohapatra P, Gopikrishnan M, Doss C GP, Chandrasekaran N (2024) How precise are nanomedicines in overcoming the blood\u2013brain barrier? A comprehensive review of the literature. Int J Nanomedicine. https:\/\/doi.org\/10.2147\/IJN.S442520","journal-title":"Int J Nanomedicine"},{"key":"5632_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.scp.2022.100606","volume":"25","author":"V Mohammadzadeh","year":"2022","unstructured":"Mohammadzadeh V, Barani M, Amiri MS, Yazdi MET, Hassanisaadi M, Rahdar A, Varma RS (2022) Applications of plant-based nanoparticles in nanomedicine: a review. Sustain Chem Pharm 25:100606","journal-title":"Sustain Chem Pharm"},{"key":"5632_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharma.2023.03.005","volume-title":"A review on plant-based remedies for the treatment of multiple sclerosis","author":"MZ Alam","year":"2023","unstructured":"Alam MZ (2023) A review on plant-based remedies for the treatment of multiple sclerosis. Elsevier, Annales pharmaceutiques francaises"},{"key":"5632_CR32","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S347187","author":"S Fakhri","year":"2022","unstructured":"Fakhri S, Abdian S, Zarneshan SN, Moradi SZ, Farzaei MH, Abdollahi M (2022) Nanoparticles in combating neuronal dysregulated signaling pathways: recent approaches to the nanoformulations of phytochemicals and synthetic drugs against neurodegenerative diseases. Int J Nanomedicine. https:\/\/doi.org\/10.2147\/IJN.S347187","journal-title":"Int J Nanomedicine"},{"issue":"1","key":"5632_CR33","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1007\/s12035-024-04310-5","volume":"62","author":"MZ Alam","year":"2025","unstructured":"Alam MZ, Bagabir HA, Zaher MAF, Alqurashi TM, Alghamdi BS, Kazi M, Ashraf GM, Alshahrany GA, et al. (2025) Black seed oil-based curcumin nanoformulations ameliorated cuprizone-induced demyelination in the mouse hippocampus. Mol Neurobiol 62(1):604\u2013625","journal-title":"Mol Neurobiol"},{"issue":"7","key":"5632_CR34","doi-asserted-by":"publisher","first-page":"923","DOI":"10.3390\/pharmaceutics16070923","volume":"16","author":"S Barathi","year":"2024","unstructured":"Barathi S, Ramalingam S, Krishnasamy G, Lee J (2024) Exploring the biomedical frontiers of plant-derived nanoparticles: synthesis and biological reactions. Pharmaceutics 16(7):923","journal-title":"Pharmaceutics"},{"key":"5632_CR35","doi-asserted-by":"publisher","first-page":"1453499","DOI":"10.3389\/fnins.2024.1453499","volume":"18","author":"R Izadi","year":"2024","unstructured":"Izadi R, Bahramikia S, Akbari V (2024) Green synthesis of nanoparticles using medicinal plants as an eco-friendly and therapeutic potential approach for neurodegenerative diseases: a comprehensive review. Front Neurosci 18:1453499","journal-title":"Front Neurosci"},{"issue":"1","key":"5632_CR36","doi-asserted-by":"publisher","DOI":"10.1080\/20565623.2025.2467591","volume":"11","author":"T Dixit","year":"2025","unstructured":"Dixit T, Vaidya A, Ravindran S (2025) Polymeric nanoparticles-based targeted delivery of drugs and bioactive compounds for arthritis management. Future Sci OA 11(1):2467591","journal-title":"Future Sci OA"},{"issue":"1","key":"5632_CR37","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1039\/C5GC01403D","volume":"18","author":"R Mohammadinejad","year":"2016","unstructured":"Mohammadinejad R, Karimi S, Iravani S, Varma RS (2016) Plant-derived nanostructures: types and applications. Green Chem 18(1):20\u201352","journal-title":"Green Chem"},{"issue":"4","key":"5632_CR38","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1007\/s10311-022-01425-w","volume":"20","author":"NTT Nguyen","year":"2022","unstructured":"Nguyen NTT, Nguyen LM, Nguyen TTT, Nguyen TT, Nguyen DTC, Tran TV (2022) Formation, antimicrobial activity, and biomedical performance of plant-based nanoparticles: a review. Environ Chem Lett 20(4):2531\u20132571","journal-title":"Environ Chem Lett"},{"issue":"1","key":"5632_CR39","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s10534-024-00648-4","volume":"38","author":"G Ibrahim Fouad","year":"2025","unstructured":"Ibrahim Fouad G, Mabrouk M, El-Sayed SA, Abdelhameed MF, Rizk MZ, Beherei HH (2025) Berberine-loaded iron oxide nanoparticles alleviate cuprizone-induced astrocytic reactivity in a rat model of multiple sclerosis. Biometals 38(1):203\u2013229","journal-title":"Biometals"},{"key":"5632_CR40","doi-asserted-by":"publisher","DOI":"10.1002\/pca.70020","author":"T Ehtezazi","year":"2025","unstructured":"Ehtezazi T, Sarker SD (2025) Phytochemical nanoparticles for the treatment of neurological disorders. Phytochem Anal. https:\/\/doi.org\/10.1002\/pca.70020","journal-title":"Phytochem Anal"},{"key":"5632_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2025.e42693","author":"S Mohammadi","year":"2025","unstructured":"Mohammadi S, Farjam H, Hosseini S, Larijani K (2025) Inhibitory effects of saffron compounds on multiple sclerosis: molecular docking and dynamic, enhancing properties with gold nanoparticles and evaluating antioxidant, antibacterial, cytotoxicity. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2025.e42693","journal-title":"Heliyon"},{"issue":"9","key":"5632_CR42","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.3390\/antiox14091128","volume":"14","author":"H-W Shi","year":"2025","unstructured":"Shi H-W, Yang B-C, Ren Y-Q, Xue Y (2025) Applications of antioxidant nanoparticles in immune-mediated inflammatory diseases. Antioxidants 14(9):1128","journal-title":"Antioxidants"},{"issue":"21","key":"5632_CR43","doi-asserted-by":"publisher","first-page":"26681","DOI":"10.1007\/s13399-022-03632-5","volume":"14","author":"T Thirugnanasambandan","year":"2024","unstructured":"Thirugnanasambandan T, Gopinath SC (2024) Nanoparticles from plant-based materials: a promising value-added green synthesis for antidiabetic. Biomass Convers Biorefin 14(21):26681\u201326691","journal-title":"Biomass Convers Biorefin"},{"key":"5632_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-018-0392-8","volume":"16","author":"JK Patra","year":"2018","unstructured":"Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MdP, Acosta-Torres LS, Diaz-Torres LA, Grillo R et al (2018) Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnology 16:1\u201333","journal-title":"J Nanobiotechnology"},{"issue":"11","key":"5632_CR45","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.1080\/10408398.2022.2131729","volume":"64","author":"N Choudhary","year":"2024","unstructured":"Choudhary N, Tewari D, Nabavi SF, Kashani HRK, Lorigooini Z, Filosa R, Khan FB, Masoudian N et al (2024) Plant based food bioactives: a boon or bane for neurological disorders. Crit Rev Food Sci Nutr 64(11):3279\u20133325","journal-title":"Crit Rev Food Sci Nutr"},{"key":"5632_CR46","volume-title":"Animal models of disease part B","author":"L Galluzzi","year":"2024","unstructured":"Galluzzi L, Vega FA, Martinez AB, Bravo-San Pedro JM (2024) Animal models of disease part B. Elsevier"},{"issue":"6","key":"5632_CR47","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.185","volume":"1","author":"P Smith","year":"2021","unstructured":"Smith P (2021) Animal models of multiple sclerosis. Curr Protoc 1(6):e185","journal-title":"Curr Protoc"},{"issue":"4","key":"5632_CR48","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1111\/j.1476-5381.2011.01302.x","volume":"164","author":"CS Constantinescu","year":"2011","unstructured":"Constantinescu CS, Farooqi N, O\u2019Brien K, Gran B (2011) Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). Br J Pharmacol 164(4):1079\u20131106","journal-title":"Br J Pharmacol"},{"key":"5632_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2020.108999","volume":"351","author":"R Aharoni","year":"2021","unstructured":"Aharoni R, Globerman R, Eilam R, Brenner O, Arnon R (2021) Titration of myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) model. J Neurosci Methods 351:108999","journal-title":"J Neurosci Methods"},{"issue":"11","key":"5632_CR50","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028977","volume":"8","author":"S Glatigny","year":"2018","unstructured":"Glatigny S, Bettelli E (2018) Experimental autoimmune encephalomyelitis (EAE) as animal models of multiple sclerosis (MS). Cold Spring Harb Perspect Med 8(11):a028977","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"1","key":"5632_CR51","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55713-7","volume":"9","author":"SK Shahi","year":"2019","unstructured":"Shahi SK, Freedman SN, Dahl RA, Karandikar NJ, Mangalam AK (2019) Scoring disease in an animal model of multiple sclerosis using a novel infrared-based automated activity-monitoring system. Sci Rep 9(1):19194","journal-title":"Sci Rep"},{"key":"5632_CR52","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00401-016-1631-4","volume":"133","author":"H Lassmann","year":"2017","unstructured":"Lassmann H, Bradl M (2017) Multiple sclerosis: experimental models and reality. Acta Neuropathol 133:223\u2013244","journal-title":"Acta Neuropathol"},{"key":"5632_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106230","volume":"184","author":"S Dedoni","year":"2023","unstructured":"Dedoni S, Scherma M, Camoglio C, Siddi C, Dazzi L, Puliga R, Frau J, Cocco E et al (2023) An overall view of the most common experimental models for multiple sclerosis. Neurobiol Dis 184:106230","journal-title":"Neurobiol Dis"},{"key":"5632_CR54","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.neuropharm.2015.07.013","volume":"99","author":"M Mohajeri","year":"2015","unstructured":"Mohajeri M, Sadeghizadeh M, Najafi F, Javan M (2015) Polymerized nano-curcumin attenuates neurological symptoms in EAE model of multiple sclerosis through down regulation of inflammatory and oxidative processes and enhancing neuroprotection and myelin repair. Neuropharmacology 99:156\u2013167","journal-title":"Neuropharmacology"},{"key":"5632_CR55","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1600-0404.2008.01036.x","volume":"117","author":"\u00d8 Torkildsen","year":"2008","unstructured":"Torkildsen \u00d8, Brunborg L, Myhr KM, B\u00f8 L (2008) The cuprizone model for demyelination. Acta Neurol Scand 117:72\u201376","journal-title":"Acta Neurol Scand"},{"key":"5632_CR56","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00073","volume":"8","author":"V Gudi","year":"2014","unstructured":"Gudi V, Gingele S, Skripuletz T, Stangel M (2014) Glial response during cuprizone-induced de-and remyelination in the CNS: lessons learned. Front Cell Neurosci 8:73","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"5632_CR57","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1046\/j.0305-1846.2001.00301.x","volume":"27","author":"J Mason","year":"2001","unstructured":"Mason J, Langaman C, Morell P, Suzuki K, Matsushima G (2001) Episodic demyelination and subsequent remyelination within the murine central nervous system: changes in axonal calibre. Neuropathol Appl Neurobiol 27(1):50\u201358","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"3","key":"5632_CR58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031445","volume":"25","author":"M Kipp","year":"2024","unstructured":"Kipp M (2024) How to use the cuprizone model to study de-and remyelination. Int J Mol Sci 25(3):1445","journal-title":"Int J Mol Sci"},{"issue":"7","key":"5632_CR59","doi-asserted-by":"publisher","first-page":"871","DOI":"10.3390\/bioengineering10070871","volume":"10","author":"K Maiese","year":"2023","unstructured":"Maiese K (2023) Cognitive impairment in multiple sclerosis. Bioengineering 10(7):871","journal-title":"Bioengineering"},{"issue":"3","key":"5632_CR60","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s13105-023-00959-z","volume":"79","author":"DM Samy","year":"2023","unstructured":"Samy DM, Zaki EI, Hassaan PS, Abdelmonsif DA, Mohamed DY, Saleh SR (2023) Neurobehavioral, biochemical and histological assessment of the effects of resveratrol on cuprizone-induced demyelination in mice: role of autophagy modulation. J Physiol Biochem 79(3):583\u2013596","journal-title":"J Physiol Biochem"},{"issue":"1","key":"5632_CR61","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.plefa.2011.04.022","volume":"85","author":"K Yoshikawa","year":"2011","unstructured":"Yoshikawa K, Palumbo S, Toscano C, Bosetti F (2011) Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage. Prostaglandins Leukot Essent Fatty Acids 85(1):43\u201352","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"5632_CR62","doi-asserted-by":"publisher","first-page":"675","DOI":"10.3389\/fpsyt.2018.00675","volume":"9","author":"Z Sun","year":"2018","unstructured":"Sun Z, Jiang T, Wu Y, Ma C, He Y, Yang J (2018) Low field magnetic stimulation ameliorates schizophrenia-like behavior and up-regulates neuregulin-1 expression in a mouse model of cuprizone-induced demyelination. Front Psychiatry 9:675","journal-title":"Front Psychiatry"},{"key":"5632_CR63","doi-asserted-by":"publisher","unstructured":"Blakemore W, Franklin\u00a0R (2008) Remyelination in experimental models of toxin-induced demyelination. Curr Top Microbiol Immunol 318:193\u2013212. https:\/\/doi.org\/10.1007\/978-3-540-73677-6_8","DOI":"10.1007\/978-3-540-73677-6_8"},{"issue":"2","key":"5632_CR64","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1242\/jcs.10.2.535","volume":"10","author":"SM Hall","year":"1972","unstructured":"Hall SM (1972) The effect of injections of lysophosphatidyl choline into white matter of the adult mouse spinal cord. J Cell Sci 10(2):535\u2013546","journal-title":"J Cell Sci"},{"key":"5632_CR65","volume":"97","author":"MB Keough","year":"2015","unstructured":"Keough MB, Jensen SK, Yong VW (2015) Experimental demyelination and remyelination of murine spinal cord by focal injection of lysolecithin. Journal of visualized experiments: JoVE 97:52679","journal-title":"Journal of visualized experiments: JoVE"},{"key":"5632_CR66","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1007\/s00705-021-04968-5","volume":"166","author":"J Libbey","year":"2021","unstructured":"Libbey J, Fujinami R (2021) Viral mouse models used to study multiple sclerosis: past and present. Arch Virol 166:1015\u20131033","journal-title":"Arch Virol"},{"key":"5632_CR67","unstructured":"Racaniello V (2001) Picornaviridae: The viruses and their replication"},{"issue":"9","key":"5632_CR68","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1099\/0022-1317-80-9-2287","volume":"80","author":"GJ Atkins","year":"1999","unstructured":"Atkins GJ, Sheahan BJ, Liljestr\u00f6m P (1999) The molecular pathogenesis of Semliki Forest virus: a model virus made useful? J Gen Virol 80(9):2287\u20132297","journal-title":"J Gen Virol"},{"issue":"3","key":"5632_CR69","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s11481-010-9202-2","volume":"5","author":"SJ Bender","year":"2010","unstructured":"Bender SJ, Weiss SR (2010) Pathogenesis of murine coronavirus in the central nervous system. J Neuroimmune Pharmacol 5(3):336\u2013354","journal-title":"J Neuroimmune Pharmacol"},{"issue":"3","key":"5632_CR70","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s11481-009-9179-x","volume":"5","author":"I Tsunoda","year":"2010","unstructured":"Tsunoda I, Fujinami RS (2010) Neuropathogenesis of Theiler\u2019s murine encephalomyelitis virus infection, an animal model for multiple sclerosis. J Neuroimmune Pharmacol 5(3):355\u2013369","journal-title":"J Neuroimmune Pharmacol"},{"issue":"1","key":"5632_CR71","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0966-842X(97)81768-4","volume":"5","author":"TE Lane","year":"1997","unstructured":"Lane TE, Buchmeier MJ (1997) Murine coronavirus infection: a paradigm for virus-induced demyelinating disease. Trends Microbiol 5(1):9\u201314","journal-title":"Trends Microbiol"},{"issue":"3","key":"5632_CR72","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1097\/WCO.0b013e328346c226","volume":"24","author":"AR Pachner","year":"2011","unstructured":"Pachner AR (2011) Experimental models of multiple sclerosis. Curr Opin Neurol 24(3):291\u2013299","journal-title":"Curr Opin Neurol"},{"key":"5632_CR73","doi-asserted-by":"publisher","first-page":"1207007","DOI":"10.3389\/fnmol.2023.1207007","volume":"16","author":"D Packer","year":"2023","unstructured":"Packer D, Fresenko EE, Harrington EP (2023) Remyelination in animal models of multiple sclerosis: finding the elusive grail of regeneration. Front Mol Neurosci 16:1207007","journal-title":"Front Mol Neurosci"},{"issue":"4","key":"5632_CR74","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1128\/jvi.69.4.2525-2533.1995","volume":"69","author":"H Lipton","year":"1995","unstructured":"Lipton H, Twaddle G, Jelachich M (1995) The predominant virus antigen burden is present in macrophages in Theiler\u2019s murine encephalomyelitis virus-induced demyelinating disease. J Virol 69(4):2525\u20132533","journal-title":"J Virol"},{"issue":"4","key":"5632_CR75","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/ana.410130409","volume":"13","author":"M Rodriguez","year":"1983","unstructured":"Rodriguez M, Leibowitz JL, Lampert PW (1983) Persistent infection of oligodendrocytes in Theiler\u2019s virus\u2010induced encephalomyelitis. Ann Neurol 13(4):426\u2013433","journal-title":"Ann Neurol"},{"key":"5632_CR76","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s13365-013-0187-5","volume":"20","author":"HL Johnson","year":"2014","unstructured":"Johnson HL, Jin F, Pirko I, Johnson AJ (2014) Theiler\u2019s murine encephalomyelitis virus as an experimental model system to study the mechanism of blood\u2013brain barrier disruption. J Neurovirol 20:107\u2013112","journal-title":"J Neurovirol"},{"issue":"10","key":"5632_CR77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111401","volume":"9","author":"HL Johnson","year":"2014","unstructured":"Johnson HL, Willenbring RC, Jin F, Manhart WA, LaFrance SJ, Pirko I, Johnson AJ (2014) Perforin competent CD8 T cells are sufficient to cause immune-mediated blood-brain barrier disruption. PLoS One 9(10):e111401","journal-title":"PLoS One"},{"key":"5632_CR78","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.pneurobio.2012.11.003","volume":"101","author":"M Mecha","year":"2013","unstructured":"Mecha M, Carrillo-Salinas FJ, Mestre L, Feliu A, Guaza C (2013) Viral models of multiple sclerosis: neurodegeneration and demyelination in mice infected with Theiler\u2019s virus. Prog Neurobiol 101:46\u201364","journal-title":"Prog Neurobiol"},{"key":"5632_CR79","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.neuroscience.2015.06.038","volume":"302","author":"L Probert","year":"2015","unstructured":"Probert L (2015) TNF and its receptors in the CNS: the essential, the desirable and the deleterious effects. Neuroscience 302:2\u201322","journal-title":"Neuroscience"},{"issue":"1","key":"5632_CR80","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.pathophys.2010.04.004","volume":"18","author":"A Denic","year":"2011","unstructured":"Denic A, Johnson AJ, Bieber AJ, Warrington AE, Rodriguez M, Pirko I (2011) The relevance of animal models in multiple sclerosis research. Pathophysiology 18(1):21\u201329","journal-title":"Pathophysiology"},{"issue":"2","key":"5632_CR81","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1037\/a0014477","volume":"123","author":"H Xu","year":"2009","unstructured":"Xu H, Yang H-J, Zhang Y, Clough R, Browning R, Li X-M (2009) Behavioral and neurobiological changes in C57BL\/6 mice exposed to cuprizone. Behav Neurosci 123(2):418","journal-title":"Behav Neurosci"},{"key":"5632_CR82","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.jconrel.2022.02.009","volume":"343","author":"N Rahiman","year":"2022","unstructured":"Rahiman N, Mohammadi M, Alavizadeh SH, Arabi L, Badiee A, Jaafari MR (2022) Recent advancements in nanoparticle-mediated approaches for restoration of multiple sclerosis. J Control Release 343:620\u2013644","journal-title":"J Control Release"},{"issue":"8","key":"5632_CR83","volume":"15","author":"C Ekhator","year":"2023","unstructured":"Ekhator C, Qureshi MQ, Zuberi AW, Hussain M, Sangroula N, Yerra S, Devi M, Naseem MA, et al. (2023) Advances and opportunities in nanoparticle drug delivery for central nervous system disorders: a review of current advances. Cureus 15(8):e44302","journal-title":"Cureus"},{"issue":"10","key":"5632_CR84","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1002\/term.3110","volume":"14","author":"M Motavaf","year":"2020","unstructured":"Motavaf M, Sadeghizadeh M, Babashah S, Zare L, Javan M (2020) Dendrosomal nanocurcumin promotes remyelination through induction of oligodendrogenesis in experimental demyelination animal model. J Tissue Eng Regen Med 14(10):1449\u20131464","journal-title":"J Tissue Eng Regen Med"},{"issue":"3","key":"5632_CR85","first-page":"310","volume":"19","author":"M Motavaf","year":"2020","unstructured":"Motavaf M, Sadeghizadeh M, Babashah S, Zare L, Javan M (2020) Protective effects of a nano-formulation of curcumin against cuprizone-induced demyelination in the mouse corpus callosum. Iran J Pharm Res 19(3):310","journal-title":"Iran J Pharm Res"},{"issue":"1","key":"5632_CR86","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3390\/v16010119","volume":"16","author":"AB DePaula-Silva","year":"2024","unstructured":"DePaula-Silva AB (2024) The contribution of microglia and brain-infiltrating macrophages to the pathogenesis of neuroinflammatory and neurodegenerative diseases during TMEV infection of the central nervous system. Viruses 16(1):119","journal-title":"Viruses"},{"issue":"4","key":"5632_CR87","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nrd.2015.21","volume":"15","author":"WA Banks","year":"2016","unstructured":"Banks WA (2016) From blood\u2013brain barrier to blood\u2013brain interface: new opportunities for CNS drug delivery. Nat Rev Drug Discov 15(4):275\u2013292","journal-title":"Nat Rev Drug Discov"},{"issue":"4","key":"5632_CR88","doi-asserted-by":"publisher","DOI":"10.3390\/biom12040538","volume":"12","author":"TG Schreiner","year":"2022","unstructured":"Schreiner TG, Romanescu C, Popescu BO (2022) The blood\u2013brain barrier\u2014a key player in multiple sclerosis disease mechanisms. Biomolecules 12(4):538","journal-title":"Biomolecules"},{"issue":"8","key":"5632_CR89","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000037297","volume":"103","author":"M Haki","year":"2024","unstructured":"Haki M, Al-Biati HA, Al-Tameemi ZS, Ali IS, Al-Hussaniy HA (2024) Review of multiple sclerosis: epidemiology, etiology, pathophysiology, and treatment. Medicine Baltimore 103(8):e37297","journal-title":"Medicine Baltimore"},{"issue":"2","key":"5632_CR90","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1080\/08916930601183522","volume":"40","author":"J Correale","year":"2007","unstructured":"Correale J, Villa A (2007) The blood\u2013brain-barrier in multiple sclerosis: functional roles and therapeutic targeting. Autoimmunity 40(2):148\u2013160","journal-title":"Autoimmunity"},{"issue":"2","key":"5632_CR91","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056375","volume":"8","author":"H Lund","year":"2013","unstructured":"Lund H, Krakauer M, Skimminge A, Sellebjerg F, Garde E, Siebner HR, Paulson OB, Hesse D, et al. (2013) Blood-brain barrier permeability of normal appearing white matter in relapsing-remitting multiple sclerosis. PLoS One 8(2):e56375","journal-title":"PLoS One"},{"key":"5632_CR92","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.jconrel.2023.10.052","volume":"364","author":"A Mwema","year":"2023","unstructured":"Mwema A, Muccioli GG, des Rieux A (2023) Innovative drug delivery strategies to the CNS for the treatment of multiple sclerosis. J Control Release 364:435\u2013457","journal-title":"J Control Release"},{"issue":"16","key":"5632_CR93","doi-asserted-by":"publisher","first-page":"8370","DOI":"10.3390\/ijms22168370","volume":"22","author":"R Balasa","year":"2021","unstructured":"Balasa R, Barcutean L, Mosora O, Manu D (2021) Reviewing the significance of blood\u2013brain barrier disruption in multiple sclerosis pathology and treatment. Int J Mol Sci 22(16):8370","journal-title":"Int J Mol Sci"},{"key":"5632_CR94","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2021.577721","volume":"360","author":"S Sriwastava","year":"2021","unstructured":"Sriwastava S, Kataria S, Srivastava S, Kazemlou S, Gao S, Wen S, Saber H, Tripathi R et al (2021) Disease-modifying therapies and progressive multifocal leukoencephalopathy in multiple sclerosis: a systematic review and meta-analysis. J Neuroimmunol 360:577721","journal-title":"J Neuroimmunol"},{"issue":"5","key":"5632_CR95","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1002\/ana.22426","volume":"69","author":"JA Cohen","year":"2011","unstructured":"Cohen JA, Chun J (2011) Mechanisms of fingolimod\u2019s efficacy and adverse effects in multiple sclerosis. Ann Neurol 69(5):759\u2013777","journal-title":"Ann Neurol"},{"issue":"8","key":"5632_CR96","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/s41578-024-00695-w","volume":"9","author":"J Gao","year":"2024","unstructured":"Gao J, Xia Z, Gunasekar S, Jiang C, Karp JM, Joshi N (2024) Precision drug delivery to the central nervous system using engineered nanoparticles. Nat Rev Mater 9(8):567\u2013588","journal-title":"Nat Rev Mater"},{"key":"5632_CR97","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1658115","volume":"16","author":"B Zhou","year":"2025","unstructured":"Zhou B, Hu B (2025) Anti-inflammatory effect of curcumin on neurological disorders: a narrative review. Front Pharmacol 16:1658115","journal-title":"Front Pharmacol"},{"key":"5632_CR98","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S208332","author":"H Yavarpour-Bali","year":"2019","unstructured":"Yavarpour-Bali H, Ghasemi-Kasman M, Pirzadeh M (2019) Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders. Int J Nanomedicine. https:\/\/doi.org\/10.2147\/IJN.S208332","journal-title":"Int J Nanomedicine"},{"issue":"12","key":"5632_CR99","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.3390\/molecules25122791","volume":"25","author":"B Zheng","year":"2020","unstructured":"Zheng B, McClements DJ (2020) Formulation of more efficacious curcumin delivery systems using colloid science: enhanced solubility, stability, and bioavailability. Molecules 25(12):2791","journal-title":"Molecules"},{"issue":"22","key":"5632_CR100","first-page":"2151","volume":"248","author":"S Godse","year":"2023","unstructured":"Godse S, Zhou L, Sakshi S, Singla B, Singh UP, Kumar S (2023) Nanocarrier-mediated curcumin delivery: an adjuvant strategy for CNS disease treatment. Exp Biol Med (Maywood) 248(22):2151\u20132166","journal-title":"Exp Biol Med (Maywood)"},{"key":"5632_CR101","doi-asserted-by":"publisher","first-page":"399","DOI":"10.3389\/fneur.2019.00399","volume":"10","author":"ST Auti","year":"2019","unstructured":"Auti ST, Kulkarni YA (2019) Neuroprotective effect of cardamom oil against aluminum induced neurotoxicity in rats. Front Neurol 10:399","journal-title":"Front Neurol"},{"issue":"10","key":"5632_CR102","doi-asserted-by":"publisher","first-page":"4024","DOI":"10.3390\/molecules28104024","volume":"28","author":"P Ballester","year":"2023","unstructured":"Ballester P, Cerd\u00e1 B, Arcusa R, Garc\u00eda-Mu\u00f1oz AM, Marhuenda J, Zafrilla P (2023) Antioxidant activity in extracts from Zingiberaceae family: cardamom, turmeric, and ginger. Molecules 28(10):4024","journal-title":"Molecules"},{"key":"5632_CR103","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1024820","volume":"9","author":"N Abdullah","year":"2022","unstructured":"Abdullah N, Ahmad W, Tian S, Zengliu Y, Zou S, Farooq QH, Xiao J (2022) Recent advances in the extraction, chemical composition, therapeutic potential, and delivery of cardamom phytochemicals. Front Nutr 9:1024820","journal-title":"Front Nutr"},{"key":"5632_CR104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neulet.2018.03.018","volume":"674","author":"R Naeimi","year":"2018","unstructured":"Naeimi R, Safarpour F, Hashemian M, Tashakorian H, Ahmadian SR, Ashrafpour M, Ghasemi-Kasman M (2018) Curcumin-loaded nanoparticles ameliorate glial activation and improve myelin repair in lyolecithin-induced focal demyelination model of rat corpus callosum. Neurosci Lett 674:1\u201310","journal-title":"Neurosci Lett"},{"issue":"3","key":"5632_CR105","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1007\/s12640-020-00310-0","volume":"39","author":"B Barzegarzadeh","year":"2021","unstructured":"Barzegarzadeh B, Hatami H, Dehghan G, Khajehnasiri N, Khoobi M, Sadeghian R (2021) Conjugated linoleic acid-curcumin attenuates cognitive deficits and oxidative stress parameters in the ethidium bromide\u2013induced model of demyelination. Neurotox Res 39(3):815\u2013825","journal-title":"Neurotox Res"},{"key":"5632_CR106","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-025-10069-x","author":"A Paul","year":"2025","unstructured":"Paul A, Mishra SS, Maji A, Samanta A, Nahar S, Maity TK (2025) Exploring the therapeutic potentials of cuminaldehyde: a comprehensive review of biological activities, mechanisms, and novel delivery systems. Phytochem Rev. https:\/\/doi.org\/10.1007\/s11101-025-10069-x","journal-title":"Phytochem Rev"},{"issue":"2","key":"5632_CR107","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.18632\/aging.202516","volume":"13","author":"Z Omari","year":"2021","unstructured":"Omari Z, Kazunori S, Sabti M, Bejaoui M, Hafidi A, Gadhi C, Isoda H (2021) Dietary administration of cumin-derived cuminaldehyde induce neuroprotective and learning and memory enhancement effects to aging mice. Aging 13(2):1671","journal-title":"Aging"},{"issue":"1","key":"5632_CR108","first-page":"35","volume":"1","author":"G Heidari","year":"2022","unstructured":"Heidari G, Hassanpour M, Nejaddehbashi F, Sarfjoo MR, Yousefiasl S, Sharifi E, Bigham A, Agarwal T, et al. (2022) Biosynthesized nanomaterials with antioxidant and antimicrobial properties. Mater Chem Horiz 1(1):35\u201348","journal-title":"Mater Chem Horiz"},{"key":"5632_CR109","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2021.160175","volume":"876","author":"R Verma","year":"2021","unstructured":"Verma R, Pathak S, Srivastava AK, Prawer S, Tomljenovic-Hanic S (2021) ZnO nanomaterials: green synthesis, toxicity evaluation and new insights in biomedical applications. J Alloys Compd 876:160175","journal-title":"J Alloys Compd"},{"issue":"3","key":"5632_CR110","doi-asserted-by":"publisher","DOI":"10.3390\/ma15030804","volume":"15","author":"T Bhattacharya","year":"2022","unstructured":"Bhattacharya T, Soares GABe, Chopra H, Rahman MM, Hasan Z, Swain SS, Cavalu S (2022) Applications of phyto-nanotechnology for the treatment of neurodegenerative disorders. Materials 15(3):804","journal-title":"Materials"},{"issue":"3","key":"5632_CR111","doi-asserted-by":"publisher","first-page":"749","DOI":"10.3390\/pharmaceutics15030749","volume":"15","author":"S Shoaib","year":"2023","unstructured":"Shoaib S, Ansari MA, Fatease AA, Safhi AY, Hani U, Jahan R, Alomary MN, Ansari MN, et al. (2023) Plant-derived bioactive compounds in the management of neurodegenerative disorders: challenges, future directions and molecular mechanisms involved in neuroprotection. Pharmaceutics 15(3):749","journal-title":"Pharmaceutics"},{"issue":"3","key":"5632_CR112","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1021\/cr200472g","volume":"113","author":"S Krol","year":"2013","unstructured":"Krol S, Macrez R, Docagne F, Defer G, Laurent S, Rahman M, Hajipour MJ, Kehoe PG et al (2013) Therapeutic benefits from nanoparticles: the potential significance of nanoscience in diseases with compromise to the blood brain barrier. Chem Rev 113(3):1877\u20131903","journal-title":"Chem Rev"},{"issue":"1\u20132","key":"5632_CR113","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.jneuroim.2010.08.011","volume":"229","author":"J Bennett","year":"2010","unstructured":"Bennett J, Basivireddy J, Kollar A, Biron KE, Reickmann P, Jefferies WA, McQuaid S (2010) Blood\u2013brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE. J Neuroimmunol 229(1\u20132):180\u2013191","journal-title":"J Neuroimmunol"},{"key":"5632_CR114","doi-asserted-by":"publisher","first-page":"175628642413066","DOI":"10.1177\/17562864241306684","volume":"17","author":"A Dal-Bianco","year":"2024","unstructured":"Dal-Bianco A, Oh J, Sati P, Absinta M (2024) Chronic active lesions in multiple sclerosis: classification, terminology, and clinical significance. Ther Adv Neurol Disord 17:17562864241306684","journal-title":"Ther Adv Neurol Disord"},{"issue":"24","key":"5632_CR115","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105442","volume":"9","author":"Z Yu","year":"2022","unstructured":"Yu Z, Fang X, Liu W, Sun R, Zhou J, Pu Y, Zhao M, Sun D et al (2022) Microglia regulate blood\u2013brain barrier integrity via MiR-126a-5p\/MMP9 axis during inflammatory demyelination. Adv Sci 9(24):2105442","journal-title":"Adv Sci"},{"issue":"1","key":"5632_CR116","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s12026-015-8719-0","volume":"63","author":"I Tabansky","year":"2015","unstructured":"Tabansky I, Messina MD, Bangeranye C, Goldstein J, Blitz-Shabbir KM, Machado S, Jeganathan V, Wright P et al (2015) Advancing drug delivery systems for the treatment of multiple sclerosis. Immunol Res 63(1):58\u201369","journal-title":"Immunol Res"},{"issue":"9","key":"5632_CR117","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1002\/cplu.202000496","volume":"85","author":"Y Liu","year":"2020","unstructured":"Liu Y, Yang G, Jin S, Xu L, Zhao CX (2020) Development of high-drug-loading nanoparticles. ChemPlusChem 85(9):2143\u20132157","journal-title":"ChemPlusChem"},{"key":"5632_CR118","doi-asserted-by":"publisher","DOI":"10.1016\/j.scowo.2024.100014","volume":"3","author":"SM Abegunde","year":"2024","unstructured":"Abegunde SM, Afolayan BO, Ilesanmi TM (2024) Ensuring sustainable plant-assisted nanoparticles synthesis through process standardization and reproducibility: challenges and future directions\u2013a review. Sustainable Chemistry One World 3:100014","journal-title":"Sustainable Chemistry One World"},{"key":"5632_CR119","doi-asserted-by":"publisher","DOI":"10.1016\/j.scowo.2024.100014","author":"SM Abegunde","year":"2024","unstructured":"Abegunde SM, Afolayan BO, Ilesanmi TM (2024) Ensuring sustainable plant-assisted nanoparticles synthesis through process standardization and reproducibility: challenges and future directions\u2013a review. Sustainable Chemistry One World. https:\/\/doi.org\/10.1016\/j.scowo.2024.100014","journal-title":"Sustainable Chemistry One World"},{"issue":"7","key":"5632_CR120","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.3390\/molecules30071572","volume":"30","author":"H Omidian","year":"2025","unstructured":"Omidian H, Cubeddu LX, Wilson RL (2025) Peptide-functionalized nanomedicine: advancements in drug delivery, diagnostics, and biomedical applications. Molecules 30(7):1572","journal-title":"Molecules"},{"issue":"7\u20138","key":"5632_CR121","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1002\/elps.202100242","volume":"43","author":"S Khizar","year":"2022","unstructured":"Khizar S, Zine N, Errachid A, Jaffrezic-Renault N, Elaissari A (2022) Microfluidic-based nanoparticle synthesis and their potential applications. Electrophoresis 43(7\u20138):819\u2013838","journal-title":"Electrophoresis"},{"key":"5632_CR122","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118449","volume":"567","author":"L Gan","year":"2019","unstructured":"Gan L, Li Z, Lv Q, Huang W (2019) Rabies virus glycoprotein (RVG29)-linked microRNA-124-loaded polymeric nanoparticles inhibit neuroinflammation in a Parkinson\u2019s disease model. Int J Pharm 567:118449","journal-title":"Int J Pharm"},{"issue":"2","key":"5632_CR123","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1021\/acs.nanolett.4c05186","volume":"25","author":"EL Han","year":"2024","unstructured":"Han EL, Tang S, Kim D, Murray AM, Swingle KL, Hamilton AG, Mrksich K, Padilla MS et al (2024) Peptide-functionalized lipid nanoparticles for targeted systemic mRNA delivery to the brain. Nano Lett 25(2):800\u2013810","journal-title":"Nano Lett"},{"issue":"2","key":"5632_CR124","first-page":"529","volume":"6","author":"Y Han","year":"2021","unstructured":"Han Y, Gao C, Wang H, Sun J, Liang M, Feng Y, Liu Q, Fu S et al (2021) Macrophage membrane-coated nanocarriers co-modified by RVG29 and TPP improve brain neuronal mitochondria-targeting and therapeutic efficacy in Alzheimer\u2019s disease mice. Bioact Mater 6(2):529\u2013542","journal-title":"Bioact Mater"},{"issue":"6","key":"5632_CR125","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/jnr.23357","volume":"92","author":"F Han","year":"2014","unstructured":"Han F, Luo B, Shi R, Han C, Zhang Z, Xiong J, Jiang M, Zhang Z (2014) Curcumin ameliorates rat experimental autoimmune neuritis. J Neurosci Res 92(6):743\u2013750","journal-title":"J Neurosci Res"},{"issue":"4","key":"5632_CR126","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1097\/WNO.0b013e3181f7f833","volume":"30","author":"KS Shindler","year":"2010","unstructured":"Shindler KS, Ventura E, Dutt M, Elliott P, Fitzgerald DC, Rostami A (2010) Oral resveratrol reduces neuronal damage in a model of multiple sclerosis. J Neuro-Ophthalmol 30(4):328\u2013339","journal-title":"J Neuro-Ophthalmol"},{"key":"5632_CR127","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1208\/s12248-015-9811-z","volume":"17","author":"MM Yallapu","year":"2015","unstructured":"Yallapu MM, Nagesh PKB, Jaggi M, Chauhan SC (2015) Therapeutic applications of curcumin nanoformulations. AAPS J 17:1341\u20131356","journal-title":"AAPS J"},{"issue":"11","key":"5632_CR128","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.3390\/pharmaceutics14112339","volume":"14","author":"DB Dos Santos","year":"2022","unstructured":"Dos Santos DB, Lemos JA, Miranda SE, Di Filippo LD, Duarte JL, Ferreira LA, Barros AL, Oliveira AE (2022) Current applications of plant-based drug delivery nano systems for leishmaniasis treatment. Pharmaceutics 14(11):2339","journal-title":"Pharmaceutics"},{"key":"5632_CR129","doi-asserted-by":"publisher","first-page":"1360302","DOI":"10.3389\/fddev.2024.1360302","volume":"4","author":"AS Haqqani","year":"2024","unstructured":"Haqqani AS, B\u00e9langer K, Stanimirovic DB (2024) Receptor-mediated transcytosis for brain delivery of therapeutics: receptor classes and criteria. Frontiers in Drug Delivery 4:1360302","journal-title":"Frontiers in Drug Delivery"},{"issue":"8","key":"5632_CR130","doi-asserted-by":"publisher","first-page":"3420","DOI":"10.1039\/D1FO00275A","volume":"12","author":"H Zhou","year":"2021","unstructured":"Zhou H, Zheng B, McClements DJ (2021) Encapsulation of lipophilic polyphenols in plant-based nanoemulsions: impact of carrier oil on lipid digestion and curcumin, resveratrol and quercetin bioaccessibility. Food Funct 12(8):3420\u20133432","journal-title":"Food Funct"},{"issue":"3","key":"5632_CR131","doi-asserted-by":"publisher","first-page":"393","DOI":"10.2174\/1381612822666161027111542","volume":"23","author":"M Gagliardi","year":"2017","unstructured":"Gagliardi M, Borri C (2017) Polymer nanoparticles as smart carriers for the enhanced release of therapeutic agents to the CNS. Curr Pharm Des 23(3):393\u2013410","journal-title":"Curr Pharm Des"},{"issue":"16","key":"5632_CR132","doi-asserted-by":"publisher","first-page":"4998","DOI":"10.3390\/molecules26164998","volume":"26","author":"H Chopra","year":"2021","unstructured":"Chopra H, Dey PS, Das D, Bhattacharya T, Shah M, Mubin S, Maishu SP, Akter R, et al. (2021) Curcumin nanoparticles as promising therapeutic agents for drug targets. Molecules 26(16):4998","journal-title":"Molecules"},{"key":"5632_CR133","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jneuroim.2019.01.007","volume":"327","author":"S Dolati","year":"2019","unstructured":"Dolati S, Babaloo Z, Ayromlou H, Ahmadi M, Rikhtegar R, Rostamzadeh D, Roshangar L, Nouri M et al (2019) Nanocurcumin improves regulatory T-cell frequency and function in patients with multiple sclerosis. J Neuroimmunol 327:15\u201321","journal-title":"J Neuroimmunol"},{"issue":"6","key":"5632_CR134","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.pharep.2018.05.008","volume":"70","author":"S Dolati","year":"2018","unstructured":"Dolati S, Ahmadi M, Aghebti-Maleki L, Nikmaram A, Marofi F, Rikhtegar R, Ayromlou H, Yousefi M (2018) Nanocurcumin is a potential novel therapy for multiple sclerosis by influencing inflammatory mediators. Pharmacol Rep 70(6):1158\u20131167","journal-title":"Pharmacol Rep"},{"issue":"1","key":"5632_CR135","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12906-024-04423-3","volume":"24","author":"F Koohpeyma","year":"2024","unstructured":"Koohpeyma F, Khodaparast Z, Salehi S, Danesh S, Gheshlagh FM, Naseri A, Montazeri-Najafabady N (2024) The ameliorative effects of curcumin nanomicelle on testicular damage in the mouse model of multiple sclerosis. BMC Complement Med Ther 24(1):200","journal-title":"BMC Complement Med Ther"},{"key":"5632_CR136","first-page":"138","volume-title":"Role of common spices in prevention and management of neurodegenerative diseases","author":"AP Ansari","year":"2024","unstructured":"Ansari AP, Ahmed NZ, Anwar N (2024) Role of common spices in prevention and management of neurodegenerative diseases. CRC Press, Medicinal plants for the management of neurodegenerative diseases, pp 138\u2013149"},{"key":"5632_CR137","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.960037","volume":"13","author":"N Norouzkhani","year":"2022","unstructured":"Norouzkhani N, Karimi AG, Badami N, Jalalifar E, Mahmoudvand B, Ansari A, Pakrou Sariyarighan N, Alijanzadeh D, et al. (2022) From kitchen to clinic: pharmacotherapeutic potential of common spices in Indian cooking in age-related neurological disorders. Front Pharmacol 13:960037","journal-title":"Front Pharmacol"},{"issue":"17","key":"5632_CR138","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.3390\/nu16172996","volume":"16","author":"S Woodfin","year":"2024","unstructured":"Woodfin S, Hall S, Ramerth A, Chapple B, Fausnacht D, Moore W, Alkhalidy H, Liu D (2024) Potential application of plant-derived compounds in multiple sclerosis management. Nutrients 16(17):2996","journal-title":"Nutrients"},{"issue":"12","key":"5632_CR139","doi-asserted-by":"publisher","first-page":"2400304","DOI":"10.1002\/smtd.202400304","volume":"8","author":"Z Duan","year":"2024","unstructured":"Duan Z, Zhou W, He S, Wang W, Huang H, Yi L, Zhang R, Chen J, et al. (2024) Intranasal delivery of curcumin nanoparticles improves neuroinflammation and neurological deficits in mice with intracerebral hemorrhage. Small Methods 8(12):2400304","journal-title":"Small Methods"},{"issue":"7","key":"5632_CR140","doi-asserted-by":"publisher","first-page":"5426","DOI":"10.1039\/D4RA07798A","volume":"15","author":"M Alaei","year":"2025","unstructured":"Alaei M, Koushki K, Taebi K, Taba MY, Hedayati SK, Shahbaz SK (2025) Metal nanoparticles in neuroinflammation: impact on microglial dynamics and CNS function. RSC Adv 15(7):5426\u20135451","journal-title":"RSC Adv"},{"issue":"1","key":"5632_CR141","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41596-021-00635-w","volume":"17","author":"C Hajal","year":"2022","unstructured":"Hajal C, Offeddu GS, Shin Y, Zhang S, Morozova O, Hickman D, Knutson CG, Kamm RD (2022) Engineered human blood\u2013brain barrier microfluidic model for vascular permeability analyses. Nat Protoc 17(1):95\u2013128","journal-title":"Nat Protoc"},{"issue":"1","key":"5632_CR142","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-01798-2","volume":"21","author":"S Palma-Florez","year":"2023","unstructured":"Palma-Florez S, L\u00f3pez-Canosa A, Moralez-Zavala F, Casta\u00f1o O, Kogan MJ, Samitier J, Lagunas A, Mir M (2023) BBB-on-a-chip with integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer\u2019s disease. J Nanobiotechnology 21(1):115","journal-title":"J Nanobiotechnology"},{"issue":"2","key":"5632_CR143","first-page":"101","volume":"22","author":"M Nadeem","year":"2012","unstructured":"Nadeem M, Riaz A (2012) Cumin (Cuminum cyminum) as a potential source of antioxidants. Pak J Food Sci 22(2):101\u2013107","journal-title":"Pak J Food Sci"},{"key":"5632_CR144","doi-asserted-by":"crossref","unstructured":"Sengupta A, Bhattacharjee\u00a0S (2009) Cardamom (Elettaria cardamomum) and its active constituent, I, 8-cineole. Molecular targets and therapeutic uses of spices: Modern uses for ancient medicine, World Scientific: 65\u201385","DOI":"10.1142\/9789812837912_0003"},{"key":"5632_CR145","first-page":"31","volume":"12","author":"C Hano","year":"2021","unstructured":"Hano C, Abbasi BH (2021) Plant-based green synthesis of nanoparticles: production, characterization and applications. MDPI 12:31","journal-title":"MDPI"},{"key":"5632_CR146","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jneumeth.2016.01.013","volume":"262","author":"R van den Berg","year":"2016","unstructured":"van den Berg R, Laman JD, van Meurs M, Hintzen RQ, Hoogenraad CC (2016) Rotarod motor performance and advanced spinal cord lesion image analysis refine assessment of neurodegeneration in experimental autoimmune encephalomyelitis. J Neurosci Methods 262:66\u201376","journal-title":"J Neurosci Methods"},{"key":"5632_CR147","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105534","volume":"160","author":"Y Shao","year":"2021","unstructured":"Shao Y, Chen C, Zhu T, Sun Z, Li S, Gong L, Dong X, Shen W et al (2021) TRPM2 contributes to neuroinflammation and cognitive deficits in a cuprizone-induced multiple sclerosis model via NLRP3 inflammasome. Neurobiol Dis 160:105534","journal-title":"Neurobiol Dis"},{"issue":"5","key":"5632_CR148","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.bbi.2010.01.011","volume":"24","author":"SJ Campbell","year":"2010","unstructured":"Campbell SJ, Meier U, Mardiguian S, Jiang Y, Littleton ET, Bristow A, Relton J, Connor TJ et al (2010) Sickness behaviour is induced by a peripheral CXC-chemokine also expressed in multiple sclerosis and EAE. Brain Behav Immun 24(5):738\u2013746","journal-title":"Brain Behav Immun"},{"issue":"3","key":"5632_CR149","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/j.1750-3639.2008.00230.x","volume":"19","author":"LC Taylor","year":"2009","unstructured":"Taylor LC, Gilmore W, Matsushima GK (2009) SJL mice exposed to cuprizone intoxication reveal strain and gender pattern differences in demyelination. Brain Pathol 19(3):467\u2013479","journal-title":"Brain Pathol"},{"key":"5632_CR150","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2020.104242","volume":"359","author":"J Wiedrick","year":"2021","unstructured":"Wiedrick J, Meza-Romero R, Gerstner G, Seifert H, Chaudhary P, Headrick A, Kent G, Maestas A et al (2021) Sex differences in EAE reveal common and distinct cellular and molecular components. Cell Immunol 359:104242","journal-title":"Cell Immunol"},{"issue":"4","key":"5632_CR151","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1002\/wnan.143","volume":"3","author":"A Chrastina","year":"2011","unstructured":"Chrastina A, Massey KA, Schnitzer JE (2011) Overcoming in vivo barriers to targeted nanodelivery. Wiley Interdiscip Rev Nanomed Nanobiotechnol 3(4):421\u2013437","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"issue":"21","key":"5632_CR152","doi-asserted-by":"publisher","first-page":"20825","DOI":"10.1021\/acsnano.3c05853","volume":"17","author":"M Xu","year":"2023","unstructured":"Xu M, Qi Y, Liu G, Song Y, Jiang X, Du B (2023) Size-dependent in vivo transport of nanoparticles: implications for delivery, targeting, and clearance. ACS Nano 17(21):20825\u201320849","journal-title":"ACS Nano"},{"issue":"3","key":"5632_CR153","doi-asserted-by":"publisher","DOI":"10.3390\/nano13030574","volume":"13","author":"TM Joseph","year":"2023","unstructured":"Joseph TM, Kar Mahapatra D, Esmaeili A, Piszczyk \u0141, Hasanin MS, Kattali M, Haponiuk J, Thomas S (2023) Nanoparticles: taking a unique position in medicine. Nanomaterials 13(3):574","journal-title":"Nanomaterials"},{"issue":"9","key":"5632_CR154","doi-asserted-by":"publisher","first-page":"5397","DOI":"10.1039\/D0CS01127D","volume":"50","author":"MS de Almeida","year":"2021","unstructured":"de Almeida MS, Susnik E, Drasler B, Taladriz-Blanco P, Petri-Fink A, Rothen-Rutishauser B (2021) Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine. Chem Soc Rev 50(9):5397\u20135434","journal-title":"Chem Soc Rev"},{"issue":"1","key":"5632_CR155","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2025.2537345","volume":"57","author":"M Liu","year":"2025","unstructured":"Liu M, Wang H, Yang Y, Wang J, Sun Z, Zhao S, Kong W, Sun W et al (2025) Therapeutic potential of plant-derived exosome-like nanoparticles for CNS diseases: advancements in preparation and characterization. Ann Med 57(1):2537345","journal-title":"Ann Med"},{"issue":"10","key":"5632_CR156","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1080\/1061186X.2024.2391913","volume":"32","author":"P Panda","year":"2024","unstructured":"Panda P, Mohapatra R (2024) Herbal nanoparticles: a targeted approach for neurodegenerative disorder treatment. J Drug Target 32(10):1233\u20131246","journal-title":"J Drug Target"},{"issue":"6","key":"5632_CR157","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1080\/17435390.2020.1770887","volume":"14","author":"RA Yokel","year":"2020","unstructured":"Yokel RA, Tseng MT, Butterfield DA, Hancock ML, Grulke EA, Unrine JM, Stromberg AJ, Dozier AK, et al. (2020) Nanoceria distribution and effects are mouse-strain dependent. Nanotoxicology 14(6):827\u2013846","journal-title":"Nanotoxicology"},{"issue":"1","key":"5632_CR158","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13578-017-0181-3","volume":"7","author":"Q Yu","year":"2017","unstructured":"Yu Q, Hui R, Park J, Huang Y, Kusnecov AW, Dreyfus CF, Zhou R (2017) Strain differences in cuprizone induced demyelination. Cell Biosci 7(1):59","journal-title":"Cell Biosci"},{"key":"5632_CR159","doi-asserted-by":"publisher","first-page":"1694752","DOI":"10.3389\/fphar.2025.1694752","volume":"16","author":"AB Pe\u00f1aherrera-Pazmi\u00f1o","year":"2025","unstructured":"Pe\u00f1aherrera-Pazmi\u00f1o AB, Criollo M, Gonzalez-Pastor R (2025) Phytochemical nanoencapsulation and microfluidics drive gene and tumor microenvironment modulation. Front Pharmacol 16:1694752","journal-title":"Front Pharmacol"},{"key":"5632_CR160","doi-asserted-by":"crossref","unstructured":"Abdukadir, A., R. Elbahrawi, N. Rabeh, S. Aljoudi, Z. Dimassi and H. Hamdan (2024). Plant-based extracts and antioxidants: implications on multiple sclerosis. Exploring the effects of diet on the development and prognosis of multiple sclerosis (MS), Springer: 139\u2013163.","DOI":"10.1007\/978-981-97-4673-6_10"},{"key":"5632_CR161","doi-asserted-by":"crossref","unstructured":"Alam, M. Z., H. A. Bagabir, M. A. F. Zaher, T. M. Alqurashi, B. S. Alghamdi, M. Kazi, G. M. Ashraf, G. A. Alshahrany et al. (2024). \u201cBlack seed oil-based curcumin nanoformulations ameliorated cuprizone-induced demyelination in the mouse hippocampus.\u201d Molecular Neurobiology: 1\u201322.","DOI":"10.1007\/s12035-024-04310-5"},{"issue":"33","key":"5632_CR162","doi-asserted-by":"publisher","first-page":"4163","DOI":"10.2174\/1381612826666200310144533","volume":"26","author":"RM Barros","year":"2020","unstructured":"Barros RM, de Oliveira MS, Costa K, Sato MR, Santos KL, de L Damasceno BP, Cuberes T, Oshiro-Junior JA (2020) Physicochemical characterization of bioactive compounds in nanocarriers. Curr Pharm Des 26(33):4163\u20134173","journal-title":"Curr Pharm Des"},{"key":"5632_CR163","doi-asserted-by":"crossref","unstructured":"Chowdhury SS, Ibnat N, Hasan\u00a0M, Ghosh (2024) Medicinal plant-based nanoparticle synthesis and their diverse applications. Ethnopharmacology and OMICS advances in medicinal plants volume 2: revealing the secrets of medicinal plants, Springer: 213\u2013250","DOI":"10.1007\/978-981-97-4292-9_10"},{"issue":"2","key":"5632_CR164","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/eji.201041104","volume":"41","author":"A Rynda-Apple","year":"2011","unstructured":"Rynda-Apple A, Huarte E, Maddaloni M, Callis G, Skyberg JA, Pascual DW (2011) Active immunization using a single dose immunotherapeutic abates established EAE via IL-10 and regulatory T cells. Eur J Immunol 41(2):313\u2013323","journal-title":"Eur J Immunol"},{"key":"5632_CR165","doi-asserted-by":"crossref","unstructured":"Tang S, Han\u00a0EL, Mitchell\u00a0MJ (2025) Peptide-functionalized nanoparticles for brain-targeted therapeutics.\u00a0Drug Delivery and Translational Research: 1\u201320","DOI":"10.1007\/s13346-025-01840-w"},{"issue":"6","key":"5632_CR166","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1002\/ana.410390608","volume":"39","author":"RR Voskuhl","year":"1996","unstructured":"Voskuhl RR, Pitchekian-Halabi H, Mackenzie-Graham A, McFarland HF, Raine CS (1996) Gender differences in autoimmune demyelination in the mouse: implications for multiple sclerosis. Ann Neurol 39(6):724\u2013733","journal-title":"Ann Neurol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05632-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-05632-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-025-05632-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T09:03:47Z","timestamp":1767690227000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-025-05632-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":166,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5632"],"URL":"https:\/\/doi.org\/10.1007\/s12035-025-05632-8","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"1 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Informed Consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"344"}}