{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:23:47Z","timestamp":1788949427171,"version":"build-2803163510"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP 2025R73"],"award-info":[{"award-number":["PNURSP 2025R73"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-026-05664-8","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T04:44:42Z","timestamp":1770007482000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Taurine Mitigates Microplastic-Induced Neurotoxicity Through Modulation of Neurobehavior, Neurotransmitters, Oxidative Stress, and AKT-1\/CREB-1\/BDNF Signaling in Mice"],"prefix":"10.1007","volume":"63","author":[{"given":"Wafa S.","family":"Alansari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman S.","family":"El-Shetry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badriyah S.","family":"Alotaibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmina M.","family":"Abd-Elhakim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany Abdel-Rahman","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enas N.","family":"Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed E.","family":"Noreldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Khamis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawal","family":"Alsubaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman A.","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"5664_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.176163","author":"T Islam","year":"2024","unstructured":"Islam T, Cheng H (2024) Existence and fate of microplastics in terrestrial environment: a global fretfulness and abatement strategies. Sci Total Environ. 953, 176163\u00a0https:\/\/doi.org\/10.1016\/j.scitotenv.2024.176163","journal-title":"Sci Total Environ"},{"issue":"5","key":"5664_CR2","doi-asserted-by":"publisher","first-page":"3447","DOI":"10.1007\/s12010-025-05189-1","volume":"197","author":"S Nayak","year":"2025","unstructured":"Nayak S, Nayak P, Soren S, Nayak S, Pradhan SP, Sharma SN, Muduli N, Saha S et al (2025) First evidence of microplastics burden in surface waters of Budhabalanga Estuary, Chandipur, Eastern India: potential threat to aquatic ecosystem. Appl Biochem Biotechnol 197(5):3447\u20133465. https:\/\/doi.org\/10.1007\/s12010-025-05189-1","journal-title":"Appl Biochem Biotechnol"},{"key":"5664_CR3","doi-asserted-by":"publisher","unstructured":"Mondal C, Mondal N, Moon UM, Biswas SJ, Hossain A (2024) Contamination of microplastics in the marine food web with special reference to seafood: present status and future concern. In P. K. Shit, D. K. Datta, B. Bera, A. Islam, & P. P. Adhikary (eds), Spatial Modeling of Environmental Pollution and Ecological Risk. Elsevier, Cambridge, MA, United States,175\u2013207. https:\/\/doi.org\/10.1016\/B978-0-323-95282-8.00035-3","DOI":"10.1016\/B978-0-323-95282-8.00035-3"},{"key":"5664_CR4","doi-asserted-by":"publisher","unstructured":"Patidar K, Alshehri M, Singha W, Alrasheedi M, Younis AM, Dumka UC, Ambade B (2025) Assessing the microplastic pandemic: prevalence, detection, and human health impacts in Asian aquatic environments. Phys Chem Earth 137, 103800. https:\/\/doi.org\/10.1016\/j.pce.2024.103800","DOI":"10.1016\/j.pce.2024.103800"},{"key":"5664_CR5","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.neuro.2024.10.008","volume":"105","author":"M Kaur","year":"2024","unstructured":"Kaur M, Sharma A, John P, Bhatnagar P (2024) Manifestation of polystyrene microplastic accumulation in brain with emphasis on morphometric and histopathological changes in limbic areas of Swiss albino mice. Neurotoxicology 105:231\u2013246. https:\/\/doi.org\/10.1016\/j.neuro.2024.10.008","journal-title":"Neurotoxicology"},{"issue":"5","key":"5664_CR6","doi-asserted-by":"publisher","first-page":"541","DOI":"10.16098\/j.issn.0529-1356.2024.05.004","volume":"55","author":"XZ Jiang","year":"2024","unstructured":"Jiang XZ, Liu Q, Sun X, Hou JS, Ma R, Cheng M, Wu YL (2024) Effects of microplastics exposure on learning and memory in mice and its mechanism. Acta Anat Sin 55(5):541\u2013546. https:\/\/doi.org\/10.16098\/j.issn.0529-1356.2024.05.004","journal-title":"Acta Anat Sin"},{"key":"5664_CR7","doi-asserted-by":"publisher","unstructured":"Wang S, Han Q, Wei Z, Wang Y, Xie J, Chen M (2022) Polystyrene microplastics affect learning and memory in\u00a0\u00a0mice by inducing oxidative stress and decreasing the level of acetylcholine. Food Chem Toxicol 162:112904. https:\/\/doi.org\/10.1016\/j.fct.2022.112904","DOI":"10.1016\/j.fct.2022.112904"},{"issue":"2","key":"5664_CR8","doi-asserted-by":"publisher","first-page":"57","DOI":"10.5281\/zenodo.14278519","volume":"9","author":"M Andreeva","year":"2024","unstructured":"Andreeva M, Petrov L, Tsvetanova E, Pramatarov G, Petrov G, Alexandrova A (2024) A pilot study of the effect of polystyrene microplastics on oxidative status in mice. Tradit Mod Vet Med 9(2):57\u201363. https:\/\/doi.org\/10.5281\/zenodo.14278519","journal-title":"Tradit Mod Vet Med"},{"issue":"3","key":"5664_CR9","doi-asserted-by":"publisher","first-page":"447","DOI":"10.4062\/biomolther.2024.185","volume":"33","author":"SB Park","year":"2025","unstructured":"Park SB, Jo JH, Kim SS, Jung WH, Bae MA, Koh B, Kim KY (2025) Microplastics accumulation induces kynurenine-derived neurotoxicity in cerebral organoids and mouse brain. Biomol Ther 33(3):447\u2013457. https:\/\/doi.org\/10.4062\/biomolther.2024.185","journal-title":"Biomol Ther"},{"key":"5664_CR10","doi-asserted-by":"publisher","unstructured":"Lee CW, Hsu LF, Wu IL, Wang YL, Chen WC, Liu YJ, Yang LT, Tan CL et al (2022) Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice. J Hazard Mater 430:128431. https:\/\/doi.org\/10.1016\/j.jhazmat.2022.128431","DOI":"10.1016\/j.jhazmat.2022.128431"},{"key":"5664_CR11","doi-asserted-by":"publisher","unstructured":"Kuai Y, Chen Z, Xie K, Chen J, He J, Gao J, Yu C (2024) Long-term exposure to polystyrene microplastics reduces macrophages and affects the microbiota\u2013gut\u2013brain axis in mice. Toxicol 509:153951. https:\/\/doi.org\/10.1016\/j.tox.2024.153951","DOI":"10.1016\/j.tox.2024.153951"},{"key":"5664_CR12","doi-asserted-by":"publisher","unstructured":"Wang C, Lin K, Zhang Z, Pan Y, Miao Q, Han X, Zhang Z, Zhu P et al (2025) Adolescent exposure to micro\/nanoplastics induces cognitive impairments in mice with neuronal morphological damage and multi-omic alterations. Environ Int 197:109323. https:\/\/doi.org\/10.1016\/j.envint.2025.109323","DOI":"10.1016\/j.envint.2025.109323"},{"issue":"1","key":"5664_CR13","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1108\/AGJSR-04-2022-0019","volume":"41","author":"N Rais","year":"2023","unstructured":"Rais N, Ved A, Shadab M, Ahmad R, Shahid M (2023) Taurine, a non-proteinous essential amino acid for human body systems: an overview. Arab Gulf J Sci Res 41(1):48\u201366. https:\/\/doi.org\/10.1108\/AGJSR-04-2022-0019","journal-title":"Arab Gulf J Sci Res"},{"key":"5664_CR14","doi-asserted-by":"publisher","first-page":"1017886","DOI":"10.3389\/fendo.2023.1017886","volume":"14","author":"Y Li","year":"2023","unstructured":"Li Y, Peng Q, Shang J, Dong W, Wu S, Guo X, Xie Z, Chen C (2023) The role of taurine in male reproduction: physiology, pathology and toxicology. No 14:1017886. https:\/\/doi.org\/10.3389\/fendo.2023.1017886","journal-title":"No"},{"issue":"1","key":"5664_CR15","doi-asserted-by":"publisher","first-page":"24","DOI":"10.4062\/biomolther.2010.18.1.024","volume":"18","author":"JA Yeon","year":"2010","unstructured":"Yeon JA, Kim SJ (2010) Neuroprotective effect of taurine against oxidative stress-induced damages in neuronal cells. Biomol Ther 18(1):24\u201331. https:\/\/doi.org\/10.4062\/biomolther.2010.18.1.024","journal-title":"Biomol Ther"},{"key":"5664_CR16","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.ejphar.2016.03.006","volume":"777","author":"Z Han","year":"2016","unstructured":"Han Z, Gao LY, Lin YH, Chang L, Wu HY, Luo CX, Zhu DY (2016) Neuroprotection of taurine against reactive oxygen species is associated with inhibiting NADPH oxidases. Eur J Pharmacol 777:129\u2013135. https:\/\/doi.org\/10.1016\/j.ejphar.2016.03.006","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"5664_CR17","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1007\/s12011-018-1552-2","volume":"190","author":"MM Ommati","year":"2019","unstructured":"Ommati MM, Heidari R, Ghanbarinejad V, Abdoli N, Niknahad H (2019) Taurine treatment provides neuroprotection in a mouse model of manganism. Biol Trace Elem Res 190(2):384\u2013395. https:\/\/doi.org\/10.1007\/s12011-018-1552-2","journal-title":"Biol Trace Elem Res"},{"key":"5664_CR18","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/978-94-024-1079-2_2","volume":"975","author":"S Tochitani","year":"2017","unstructured":"Tochitani S (2017) Functions of maternally-derived taurine in fetal and neonatal brain development. Adv Exp Med Biol 975:17\u201325. https:\/\/doi.org\/10.1007\/978-94-024-1079-2_2","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"5664_CR19","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1017\/S0317167100014840","volume":"40","author":"HB Ye","year":"2013","unstructured":"Ye HB, Shi HB, Yin SK (2013) Mechanisms underlying taurine protection against glutamate-induced neurotoxicity. Can J Neurol Sci 40(5):628\u2013634. https:\/\/doi.org\/10.1017\/S0317167100014840","journal-title":"Can J Neurol Sci"},{"issue":"5","key":"5664_CR20","doi-asserted-by":"publisher","first-page":"450","DOI":"10.4062\/biomolther.2018.218","volume":"27","author":"JH Jung","year":"2019","unstructured":"Jung JH, Kim SJ (2019) Anxiolytic action of taurine via intranasal administration in mice. Biomol Ther 27(5):450\u2013456. https:\/\/doi.org\/10.4062\/biomolther.2018.218","journal-title":"Biomol Ther"},{"key":"5664_CR21","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/978-3-030-93337-1_42","volume":"1370","author":"LS Neuwirth","year":"2022","unstructured":"Neuwirth LS, Emenike BU, Cruz GB, Caba\u00f1as E, Vasquez MA, Joseph JN, Ayaz Z, Mian M et al (2022) Taurine-derived compounds produce anxiolytic effects in rats following developmental lead exposure. Adv Exp Med Biol 1370:445\u2013460. https:\/\/doi.org\/10.1007\/978-3-030-93337-1_42","journal-title":"Adv Exp Med Biol"},{"key":"5664_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cbi.2016.11.011","volume":"261","author":"IA Adedara","year":"2017","unstructured":"Adedara IA, Abolaji AO, Idris UF, Olabiyi BF, Onibiyo EM, Ojuade TD, Farombi EO (2017) Neuroprotective influence of taurine on fluoride-induced biochemical and behavioral deficits in rats. Chem Biol Interact 261:1\u201310. https:\/\/doi.org\/10.1016\/j.cbi.2016.11.011","journal-title":"Chem Biol Interact"},{"key":"5664_CR23","doi-asserted-by":"publisher","first-page":"1665161","DOI":"10.3389\/fphar.2025.1665161","volume":"16","author":"A Eskandrani","year":"2025","unstructured":"Eskandrani A, Abdel-Rahman Mohamed A, Alotaibi B, Abd-Elhakim YM, Khamis T, Noreldin EA, Abdelhamid EA, Alsubaie N et al (2025) Palliative effect of taurine against hepatic injury induced by polystyrene microplastics through antioxidant and metabolic pathway modulation in mice. Front Pharmacol 16:1665161. https:\/\/doi.org\/10.3389\/fphar.2025.1665161","journal-title":"Front Pharmacol"},{"issue":"5","key":"5664_CR24","doi-asserted-by":"publisher","first-page":"4516","DOI":"10.3892\/mmr.2018.9465","volume":"18","author":"X Niu","year":"2018","unstructured":"Niu X, Zheng S, Liu H, Li S (2018) Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury. Mol Med Rep 18(5):4516\u20134522. https:\/\/doi.org\/10.3892\/mmr.2018.9465","journal-title":"Mol Med Rep"},{"key":"5664_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.104907","volume":"61","author":"S Song","year":"2024","unstructured":"Song S, He S, Lin Q, Jin H (2024) Synergistic effect of collagen peptide LR-7 and taurine on the prevention of cardiovascular injury in high salt-induced hypertensive mice. Food Biosci 61:104907. https:\/\/doi.org\/10.1016\/j.fbio.2024.104907","journal-title":"Food Biosci"},{"key":"5664_CR26","doi-asserted-by":"publisher","first-page":"124004","DOI":"10.1016\/j.jhazmat.2020.124004","volume":"404","author":"K Senathirajah","year":"2021","unstructured":"Senathirajah K, Attwood S, Bhagwat G, Carbery M, Wilson S, Palanisami T (2021) Estimation of the mass of microplastics ingested \u2013 a pivotal first step towards human health risk assessment. J Hazard Mater 404:124004. https:\/\/doi.org\/10.1016\/j.jhazmat.2020.124004","journal-title":"J Hazard Mater"},{"issue":"2","key":"5664_CR27","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1007\/s11356-016-7949-6","volume":"24","author":"JM de Souza","year":"2017","unstructured":"de Souza JM, da Silva WAM, de Oliveira Mens B, Guimar\u00e3es ATB, de Lima Rodrigues AS, Montalv\u00e3o MF, da Costa Estrela D, da Silva AR et al (2017) Inbred mice strain shows neurobehavioral changes when exposed to tannery effluent. Environ Sci Pollut Res 24(2):2035\u20132046. https:\/\/doi.org\/10.1007\/s11356-016-7949-6","journal-title":"Environ Sci Pollut Res"},{"key":"5664_CR28","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.scitotenv.2017.09.051","volume":"613","author":"JM de Souza","year":"2018","unstructured":"de Souza JM, Mendes BdO, Guimar\u00e3es ATB, Rodrigues ASdL, Chagas TQ, Rocha TL, Malafaia G (2018) Zinc oxide nanoparticles in predicted environmentally relevant concentrations leading to behavioral impairments in male swiss mice. Sci Total Environ 613:653\u2013662. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.09.051","journal-title":"Sci Total Environ"},{"issue":"1","key":"5664_CR29","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/0006-8993(92)91352-F","volume":"588","author":"F Dellu","year":"1992","unstructured":"Dellu F, Mayo W, Cherkaoui J, Le Moal M, Simon H (1992) A two-trial memory task with automated recording: study in young and aged rats. Brain Res 588(1):132\u2013139. https:\/\/doi.org\/10.1016\/0006-8993(92)91352-F","journal-title":"Brain Res"},{"key":"5664_CR30","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.neuropharm.2013.07.005","volume":"75","author":"S Krishnamurthy","year":"2013","unstructured":"Krishnamurthy S, Garabadu D, Joy KP (2013) Risperidone ameliorates post-traumatic stress disorder-like symptoms in modified stress re-stress model. Neuropharmacology 75:62\u201377. https:\/\/doi.org\/10.1016\/j.neuropharm.2013.07.005","journal-title":"Neuropharmacology"},{"issue":"2","key":"5664_CR31","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351\u2013358","journal-title":"Anal Biochem"},{"issue":"5","key":"5664_CR32","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1136\/jcp.54.5.356","volume":"54","author":"D Koracevic","year":"2001","unstructured":"Koracevic D, Koracevic G, Djordjevic V, Andrejevic S, Cosic V (2001) Method for the measurement of antioxidant activity in human fluids. J Clin Pathol 54(5):356\u2013361","journal-title":"J Clin Pathol"},{"key":"5664_CR33","doi-asserted-by":"crossref","unstructured":"Bancroft JD, Layton C (2013) The hematoxylin and eosin, connective and mesenchymal tissues with their stains. In: Suvarna SK, Layton C, Bancroft JD (eds) Theory and practice of histological techniques, 7th edn. Churchill Livingstone, Philadelphia, pp 173\u2013186","DOI":"10.1016\/B978-0-7020-4226-3.00010-X"},{"issue":"6","key":"5664_CR34","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1177\/0300985813485099","volume":"50","author":"KN Gibson-Corley","year":"2013","unstructured":"Gibson-Corley KN, Olivier AK, Meyerholz DK (2013) Principles for valid histopathologic scoring in research. Vet Pathol 50(6):1007\u20131015. https:\/\/doi.org\/10.1177\/0300985813485099","journal-title":"Vet Pathol"},{"key":"5664_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/gb-2002-3-7-research0034","volume":"3","author":"J Vandesompele","year":"2002","unstructured":"Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3:1\u201312. https:\/\/doi.org\/10.1186\/gb-2002-3-7-research0034","journal-title":"Genome Biol"},{"issue":"6","key":"5664_CR36","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative CT method. Nat Protoc 3(6):1101\u20131108","journal-title":"Nat Protoc"},{"key":"5664_CR37","unstructured":"Spss I (2011) IBM SPSS Statistics for Windows (Version 20.0). Armonk, NY: IBM Corp.\u00a0"},{"key":"5664_CR38","unstructured":"\u00a0 Prism G (2019) Prism 8 for windows. GraphPad Software Inc., San Diego, CA, USA.\u00a0"},{"key":"5664_CR39","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.tifs.2017.12.006","volume":"72","author":"D Granato","year":"2018","unstructured":"Granato D, Santos JS, Escher GB, Ferreira BL, Maggio RM (2018) Use of principal component analysis (PCA) and hierarchical cluster analysis (HCA) for multivariate association between bioactive compounds and functional properties in foods: a critical perspective. Trends Food Sci Technol 72:83\u201390. https:\/\/doi.org\/10.1016\/j.tifs.2017.12.006","journal-title":"Trends Food Sci Technol"},{"issue":"11","key":"5664_CR40","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.biopsych.2020.06.018","volume":"88","author":"SR DeGroot","year":"2020","unstructured":"DeGroot SR, Zhao-Shea R, Chung L, Klenowski PM, Sun F, Molas S, Gardner PD, Li Y et al (2020) Midbrain dopamine controls anxiety-like behavior by engaging unique interpeduncular nucleus microcircuitry. Biol Psychiatry 88(11):855\u2013866. https:\/\/doi.org\/10.1016\/j.biopsych.2020.06.018","journal-title":"Biol Psychiatry"},{"key":"5664_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00923","author":"P Hepsomali","year":"2020","unstructured":"Hepsomali P, Groeger JA, Nishihira J, Scholey A (2020) Effects of oral gamma-aminobutyric acid (GABA) administration on stress and sleep in humans: a systematic review. Front Neurosci. https:\/\/doi.org\/10.3389\/fnins.2020.00923","journal-title":"Front Neurosci"},{"issue":"8","key":"5664_CR42","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1007\/s11011-023-01317-0","volume":"38","author":"R Saberi","year":"2023","unstructured":"Saberi R, Mirazi N, Amirahmadi S, Darbandi ZK, Vafaee F, Rajabian A, Hosseini M (2023) Ameliorative effects of thiamin on learning behavior and memory dysfunction in a rat model of hypothyroidism: implication of oxidative stress and acetylcholinesterase. Metab Brain Dis 38(8):2603\u20132613. https:\/\/doi.org\/10.1007\/s11011-023-01317-0","journal-title":"Metab Brain Dis"},{"issue":"3","key":"5664_CR43","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.bbi.2007.09.006","volume":"22","author":"I Shapira-Lichter","year":"2008","unstructured":"Shapira-Lichter I, Beilin B, Ofek K, Bessler H, Gruberger M, Shavit Y, Seror D, Grinevich G et al (2008) Cytokines and cholinergic signals co-modulate surgical stress-induced changes in mood and memory. Brain Behav Immun 22(3):388\u2013398. https:\/\/doi.org\/10.1016\/j.bbi.2007.09.006","journal-title":"Brain Behav Immun"},{"issue":"4","key":"5664_CR44","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.neuron.2016.01.011","volume":"89","author":"N Padilla-Coreano","year":"2016","unstructured":"Padilla-Coreano N, Bolkan SS, Pierce GM, Blackman DR, Hardin WD, Garcia-Garcia AL, Spellman TJ, Gordon JA (2016) Direct ventral hippocampal-prefrontal input is required for anxiety-related neural activity and behavior. Neuron 89(4):857\u2013866. https:\/\/doi.org\/10.1016\/j.neuron.2016.01.011","journal-title":"Neuron"},{"issue":"3","key":"5664_CR45","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.neuron.2018.01.016","volume":"97","author":"JC Jimenez","year":"2018","unstructured":"Jimenez JC, Su K, Goldberg AR, Luna VM, Biane JS, Ordek G, Zhou P, Ong SK et al (2018) Anxiety cells in a hippocampal-hypothalamic circuit. Neuron 97(3):670-683.e676. https:\/\/doi.org\/10.1016\/j.neuron.2018.01.016","journal-title":"Neuron"},{"issue":"2","key":"5664_CR46","doi-asserted-by":"publisher","first-page":"120","DOI":"10.2174\/1570159x11666131120232135","volume":"12","author":"W Hassan","year":"2014","unstructured":"Hassan W, Silva CE, Mohammadzai IU, da Rocha JB, J LF (2014) Association of oxidative stress to the genesis of anxiety: implications for possible therapeutic interventions. Curr Neuropharmacol 12(2):120\u2013139. https:\/\/doi.org\/10.2174\/1570159x11666131120232135","journal-title":"Curr Neuropharmacol"},{"key":"5664_CR47","doi-asserted-by":"publisher","unstructured":"Liu F, Bai Q, Tang W, Zhang S, Guo Y, Pan S, Ma X, Yang Y et al (2024) Antioxidants in neuropsychiatric disorder prevention: neuroprotection, synaptic regulation, microglia modulation, and neurotrophic effects. Front Neurosci 18: 1505153. https:\/\/doi.org\/10.3389\/fnins.2024.1505153","DOI":"10.3389\/fnins.2024.1505153"},{"issue":"1","key":"5664_CR48","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jneuroim.2008.08.015","volume":"205","author":"E Tyagi","year":"2008","unstructured":"Tyagi E, Agrawal R, Nath C, Shukla R (2008) Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brain. J Neuroimmunol 205(1):51\u201356. https:\/\/doi.org\/10.1016\/j.jneuroim.2008.08.015","journal-title":"J Neuroimmunol"},{"issue":"4","key":"5664_CR49","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1007\/s11011-019-00432-1","volume":"34","author":"N Samad","year":"2019","unstructured":"Samad N, Jabeen S, Imran I, Zulfiqar I, Bilal K (2019) Protective effect of gallic acid against arsenic-induced anxiety\u2212\/depression- like behaviors and memory impairment in male rats. Metab Brain Dis 34(4):1091\u20131102. https:\/\/doi.org\/10.1007\/s11011-019-00432-1","journal-title":"Metab Brain Dis"},{"issue":"1","key":"5664_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00726-021-03104-6","volume":"54","author":"K Wang","year":"2022","unstructured":"Wang K, Zhang B, Tian T, Zhang B, Shi G, Zhang C, Li G, Huang M (2022) Taurine protects dopaminergic neurons in paraquat-induced Parkinson\u2019s disease mouse model through PI3K\/Akt signaling pathways. Amino Acids 54(1):1\u201311. https:\/\/doi.org\/10.1007\/s00726-021-03104-6","journal-title":"Amino Acids"},{"key":"5664_CR51","doi-asserted-by":"publisher","unstructured":"Lamoreaux WJ, Marsillo A, El Idrissi A (2010) Pharmacological characterization of GABAA receptors in taurine-fed mice. J Biomed Sci 17: (Suppl 1), S14. https:\/\/doi.org\/10.1186\/1423-0127-17-S1-S14","DOI":"10.1186\/1423-0127-17-S1-S14"},{"key":"5664_CR52","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/978-94-024-1079-2_4","volume":"975","author":"LS Neuwirth","year":"2017","unstructured":"Neuwirth LS, Volpe NP, Corwin C, Ng S, Madan N, Ferraro AM, Furman Y, El Idrissi A (2017) Taurine recovery of learning deficits induced by developmental Pb2+ exposure. Adv Exp Med Biol 975:39\u201355. https:\/\/doi.org\/10.1007\/978-94-024-1079-2_4","journal-title":"Adv Exp Med Biol"},{"issue":"12","key":"5664_CR53","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10121876","volume":"10","author":"PF Surai","year":"2021","unstructured":"Surai PF, Earle-Payne K, Kidd MT (2021) Taurine as a natural antioxidant: from direct antioxidant effects to protective action in various toxicological models. Antioxidants 10(12):1876. https:\/\/doi.org\/10.3390\/antiox10121876","journal-title":"Antioxidants"},{"issue":"10","key":"5664_CR54","doi-asserted-by":"publisher","first-page":"623","DOI":"10.32383\/farmpol\/181132","volume":"79","author":"M Cie\u015blak","year":"2023","unstructured":"Cie\u015blak M, Karma\u0144ska A, Ka\u017amierczak-Bara\u0144ska J, Korycka M, Karwowski B (2023) Neuroprotective properties of taurine. Farm Pol 79(10):623\u2013634. https:\/\/doi.org\/10.32383\/farmpol\/181132","journal-title":"Farm Pol"},{"issue":"1","key":"5664_CR55","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.bbi.2008.06.011","volume":"23","author":"VA Pavlov","year":"2009","unstructured":"Pavlov VA, Parrish WR, Rosas-Ballina M, Ochani M, Puerta M, Ochani K, Chavan S, Al-Abed Y et al (2009) Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway. Brain Behav Immun 23(1):41\u201345. https:\/\/doi.org\/10.1016\/j.bbi.2008.06.011","journal-title":"Brain Behav Immun"},{"issue":"3","key":"5664_CR56","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s12640-019-0003-y","volume":"35","author":"SN Rai","year":"2019","unstructured":"Rai SN, Dilnashin H, Birla H, Singh SS, Zahra W, Rathore AS, Singh BK, Singh SP (2019) The role of PI3K\/Akt and ERK in neurodegenerative disorders. Neurotox Res 35(3):775\u2013795","journal-title":"Neurotox Res"},{"issue":"1","key":"5664_CR57","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s12888-023-04718-8","volume":"23","author":"S Li","year":"2023","unstructured":"Li S, Lu C, Kang L, Li Q, Chen H, Zhang H, Tang Z, Lin Y et al (2023) Study on correlations of BDNF, PI3K, AKT and CREB levels with depressive emotion and impulsive behaviors in drug-na\u00efve patients with first-episode schizophrenia. BMC Psychiatry 23(1):225. https:\/\/doi.org\/10.1186\/s12888-023-04718-8","journal-title":"BMC Psychiatry"},{"issue":"6","key":"5664_CR58","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.5114\/aoms.2015.56342","volume":"11","author":"S Bathina","year":"2015","unstructured":"Bathina S, Das UN (2015) Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci 11(6):1164\u20131178. https:\/\/doi.org\/10.5114\/aoms.2015.56342","journal-title":"Arch Med Sci"},{"issue":"9","key":"5664_CR59","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1016\/j.neurobiolaging.2007.02.027","volume":"29","author":"L Tong","year":"2008","unstructured":"Tong L, Balazs R, Soiampornkul R, Thangnipon W, Cotman CW (2008) Interleukin-1\u03b2 impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol Aging 29(9):1380\u20131393. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2007.02.027","journal-title":"Neurobiol Aging"},{"key":"5664_CR60","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-018-0455-7","author":"YL Dong","year":"2018","unstructured":"Dong YL, Pu KJ, Duan WJ, Chen HC, Chen LX, Wang YM (2018) Involvement of Akt\/CREB signaling pathways in the protective effect of EPA against interleukin-1\u03b2-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons. BMC Neurosci. https:\/\/doi.org\/10.1186\/s12868-018-0455-7","journal-title":"BMC Neurosci"},{"key":"5664_CR61","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.bcp.2018.01.047","volume":"151","author":"MA Rabie","year":"2018","unstructured":"Rabie MA, Abd El Fattah MA, Nassar NN, El-Abhar HS, Abdallah DM (2018) Angiotensin 1\u20137 ameliorates 6-hydroxydopamine lesions in hemiparkinsonian rats through activation of MAS receptor\/PI3K\/Akt\/BDNF pathway and inhibition of angiotensin II type-1 receptor\/NF-\u03baB axis. Biochem Pharmacol 151:126\u2013134. https:\/\/doi.org\/10.1016\/j.bcp.2018.01.047","journal-title":"Biochem Pharmacol"},{"key":"5664_CR62","doi-asserted-by":"publisher","unstructured":"Khidr HY, Hassan NF, Abdelrahman SS, El-Ansary MR, El-Yamany MF, Rabie MA (2023) Formoterol attenuated mitochondrial dysfunction in rotenone-induced Parkinson's disease in a rat model: role of PINK-1\/PARKIN and PI3K\/Akt\/CREB\/BDNF\/TrKB axis. Int Immunopharmacol 125, 111207. https:\/\/doi.org\/10.1016\/j.intimp.2023.111207","DOI":"10.1016\/j.intimp.2023.111207"},{"key":"5664_CR63","doi-asserted-by":"publisher","unstructured":"Zarneshan SN, Fakhri S, Khan H (2022) Targeting Akt\/CREB\/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: a mechanistic approach. Pharmacol Res 177, 106099. https:\/\/doi.org\/10.1016\/j.phrs.2022.106099","DOI":"10.1016\/j.phrs.2022.106099"},{"key":"5664_CR64","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.redox.2016.10.004","volume":"10","author":"N Jia","year":"2016","unstructured":"Jia N, Sun Q, Su Q, Dang S, Chen G (2016) Taurine promotes cognitive function in prenatally stressed juvenile rats via activating the Akt-CREB-PGC1\u03b1 pathway. Redox Biol 10:179\u2013190. https:\/\/doi.org\/10.1016\/j.redox.2016.10.004","journal-title":"Redox Biol"},{"key":"5664_CR65","doi-asserted-by":"publisher","first-page":"104503","DOI":"10.1016\/j.cellimm.2022.104503","volume":"375","author":"Y Ma","year":"2022","unstructured":"Ma Y, Zhang Y, Li R, Deng S, Qin Q, Ran C, Hao Y, Zhang J et al (2022) Mechanism of taurine reducing inflammation and organ injury in sepsis mice. Cell Immunol 375:104503. https:\/\/doi.org\/10.1016\/j.cellimm.2022.104503","journal-title":"Cell Immunol"},{"issue":"1","key":"5664_CR66","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12937-021-00712-6","volume":"20","author":"M Vahdat","year":"2021","unstructured":"Vahdat M, Hosseini SA, Soltani F, Cheraghian B, Namjoonia M (2021) The effects of Taurine supplementation on inflammatory markers and clinical outcomes in patients with traumatic brain injury: a double-blind randomized controlled trial. Nutr J 20(1):53. https:\/\/doi.org\/10.1186\/s12937-021-00712-6","journal-title":"Nutr J"},{"issue":"1","key":"5664_CR67","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-020-0518-7","volume":"12","author":"V Maleki","year":"2020","unstructured":"Maleki V, Mahdavi R, Hajizadeh-Sharafabad F, Alizadeh M (2020) The effects of taurine supplementation on oxidative stress indices and inflammation biomarkers in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Diabetol Metab Syndr 12(1):9. https:\/\/doi.org\/10.1186\/s13098-020-0518-7","journal-title":"Diabetol Metab Syndr"},{"issue":"8","key":"5664_CR68","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1007\/s10529-015-1846-9","volume":"37","author":"M Qiao","year":"2015","unstructured":"Qiao M, Liu P, Ren X, Feng T, Zhang Z (2015) Potential protection of taurine on antioxidant system and ATPase in brain and blood of rats exposed to aluminum. Biotechnol Lett 37(8):1579\u20131584. https:\/\/doi.org\/10.1007\/s10529-015-1846-9","journal-title":"Biotechnol Lett"},{"issue":"9","key":"5664_CR69","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1007\/s00726-016-2244-x","volume":"48","author":"Q Wang","year":"2016","unstructured":"Wang Q, Fan W, Cai Y, Wu Q, Mo L, Huang Z, Huang H (2016) Protective effects of taurine in traumatic brain injury via mitochondria and cerebral blood flow. Amino Acids 48(9):2169\u20132177. https:\/\/doi.org\/10.1007\/s00726-016-2244-x","journal-title":"Amino Acids"},{"issue":"11","key":"5664_CR70","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1016\/0006-2952(95)02046-2","volume":"50","author":"I Tamai","year":"1995","unstructured":"Tamai I, Senmaru M, Terasaki T, Tsuji A (1995) Na(+)- and Cl(-)-dependent transport of taurine at the blood-brain barrier. Biochem Pharmacol 50(11):1783\u20131793. https:\/\/doi.org\/10.1016\/0006-2952(95)02046-2","journal-title":"Biochem Pharmacol"},{"key":"5664_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmpk.2024.101040","volume":"61","author":"Y Tega","year":"2025","unstructured":"Tega Y, Kawauchi Y, Akanuma SI, Inagaki M, Tachikawa M, Hosoya KI (2025) In vitro characterization of taurine transport using the human brain microvascular endothelial cell line as a human blood-brain barrier model. Drug Metab Pharmacokinet 61:101040. https:\/\/doi.org\/10.1016\/j.dmpk.2024.101040","journal-title":"Drug Metab Pharmacokinet"},{"issue":"5","key":"5664_CR72","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1046\/j.1471-4159.2002.01223.x","volume":"83","author":"YS Kang","year":"2002","unstructured":"Kang YS, Ohtsuki S, Takanaga H, Tomi M, Hosoya K, Terasaki T (2002) Regulation of taurine transport at the blood-brain barrier by tumor necrosis factor-alpha, taurine and hypertonicity. J Neurochem 83(5):1188\u20131195. https:\/\/doi.org\/10.1046\/j.1471-4159.2002.01223.x","journal-title":"J Neurochem"},{"key":"5664_CR73","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15030746","author":"R Maher","year":"2023","unstructured":"Maher R, Moreno-Borrallo A, Jindal D, Mai BT, Ruiz-Hernandez E, Harkin A (2023) Intranasal polymeric and lipid-based nanocarriers for CNS drug delivery. Pharmaceutics. https:\/\/doi.org\/10.3390\/pharmaceutics15030746","journal-title":"Pharmaceutics"},{"issue":"2","key":"5664_CR74","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1039\/c5bm00383k","volume":"4","author":"T-T Zhang","year":"2016","unstructured":"Zhang T-T, Li W, Meng G, Wang P, Liao W (2016) Strategies for transporting nanoparticles across the blood\u2013brain barrier. Biomater Sci 4(2):219\u2013229. https:\/\/doi.org\/10.1039\/c5bm00383k","journal-title":"Biomater Sci"},{"issue":"10","key":"5664_CR75","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.3390\/ph5101128","volume":"5","author":"MC Chung","year":"2012","unstructured":"Chung MC, Malatesta P, Bosquesi PL, Yamasaki PR, Santos JL, Vizioli EO (2012) Advances in drug design based on the amino acid approach: taurine analogues for the treatment of CNS diseases. Pharmaceuticals 5(10):1128\u20131146. https:\/\/doi.org\/10.3390\/ph5101128","journal-title":"Pharmaceuticals"},{"key":"5664_CR76","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.130004","volume":"442","author":"ATB Guimar\u00e3es","year":"2023","unstructured":"Guimar\u00e3es ATB, Freitas \u00cdN, Mubarak NM, Rahman MM, Rodrigues FP, Rodrigues ASL, Barcel\u00f3 D, Islam A et al (2023) Exposure to polystyrene nanoplastics induces an anxiolytic-like effect, changes in antipredator defensive response, and DNA damage in Swiss mice. J Hazard Mater 442:130004. https:\/\/doi.org\/10.1016\/j.jhazmat.2022.130004","journal-title":"J Hazard Mater"},{"issue":"7","key":"5664_CR77","doi-asserted-by":"publisher","first-page":"9323","DOI":"10.1007\/s00210-025-03867-9","volume":"398","author":"NA Kamel","year":"2025","unstructured":"Kamel NA, Bashir DW, El-Leithy EMM, Tohamy AF, Rashad MM, Ali GE, El-Saba AAA (2025) Polyethylene terephthalate nanoplastics-induced neurotoxicity in adult male Swiss albino mice with amelioration of betaine: a histopathological, neurochemical, and molecular investigation. Naunyn-Schmiedebergs Arch Pharmacol 398(7):9323\u20139339. https:\/\/doi.org\/10.1007\/s00210-025-03867-9","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"5664_CR78","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s12915-023-01751-7","volume":"21","author":"P Kahnau","year":"2023","unstructured":"Kahnau P, Mieske P, Wilzopolski J, Kalliokoski O, Mandillo S, H\u00f6lter SM, Voikar V, Amfim A et al (2023) A systematic review of the development and application of home cage monitoring in laboratory mice and rats. BMC Biol 21(1):256. https:\/\/doi.org\/10.1186\/s12915-023-01751-7","journal-title":"BMC Biol"},{"key":"5664_CR79","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104962","volume":"143","author":"AM Kaluve","year":"2022","unstructured":"Kaluve AM, Le JT, Graham BM (2022) Female rodents are not more variable than male rodents: a meta-analysis of preclinical studies of fear and anxiety. Neurosci Biobehav Rev 143:104962. https:\/\/doi.org\/10.1016\/j.neubiorev.2022.104962","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"5664_CR80","doi-asserted-by":"publisher","DOI":"10.1186\/s40580-024-00448-z","volume":"11","author":"Y Cho","year":"2024","unstructured":"Cho Y, Seo EU, Hwang KS, Kim H, Choi J, Kim HN (2024) Evaluation of size-dependent uptake, transport and cytotoxicity of polystyrene microplastic in a blood-brain barrier (BBB) model. Nano Convergence 11(1):40. https:\/\/doi.org\/10.1186\/s40580-024-00448-z","journal-title":"Nano Convergence"},{"key":"5664_CR81","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2025.1619096","volume":"7","author":"SJ Fang","year":"2025","unstructured":"Fang SJ, Yin ZD, Li LF, Cai Q, Zheng PF, Chen LZ (2025) Overall effects of microplastics on brain. Front Toxicol 7:1619096. https:\/\/doi.org\/10.3389\/ftox.2025.1619096","journal-title":"Front Toxicol"},{"issue":"8","key":"5664_CR82","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.3390\/nano13081404","volume":"13","author":"V Kopatz","year":"2023","unstructured":"Kopatz V, Wen K, Kov\u00e1cs T, Keimowitz AS, Pichler V, Widder J, Vethaak AD, Holl\u00f3czki O et al (2023) Micro- and nanoplastics breach the blood\u2013brain barrier (BBB): biomolecular corona\u2019s role revealed. Nanomaterials 13(8):1404. https:\/\/doi.org\/10.3390\/nano13081404","journal-title":"Nanomaterials"},{"key":"5664_CR83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.129652","volume":"439","author":"L Hu","year":"2022","unstructured":"Hu L, Zhao Y, Xu H (2022) Trojan horse in the intestine: a review on the biotoxicity of microplastics combined environmental contaminants. J Hazard Mater 439:129652. https:\/\/doi.org\/10.1016\/j.jhazmat.2022.129652","journal-title":"J Hazard Mater"},{"key":"5664_CR84","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.132584","volume":"461","author":"Y Lan","year":"2024","unstructured":"Lan Y, Hu L, Feng X, Wang M, Yuan H, Xu H (2024) Synergistic effect of PS-MPs and Cd on male reproductive toxicity: ferroptosis via Keap1-Nrf2 pathway. J Hazard Mater 461:132584. https:\/\/doi.org\/10.1016\/j.jhazmat.2023.132584","journal-title":"J Hazard Mater"},{"key":"5664_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.133587","volume":"466","author":"L Hu","year":"2024","unstructured":"Hu L, Feng X, Lan Y, Zhang J, Nie P, Xu H (2024) Co-exposure with cadmium elevates the toxicity of microplastics: trojan horse effect from the perspective of intestinal barrier. J Hazard Mater 466:133587. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.133587","journal-title":"J Hazard Mater"},{"issue":"9","key":"5664_CR86","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1177\/0271678X20943823","volume":"40","author":"Sert N du Percie","year":"2020","unstructured":"du Percie Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A et al (2020) The ARRIVE guidelines 2.0: updated guidelines for reporting animal research*. J Cereb Blood Flow Metab 40(9):1769\u20131777. https:\/\/doi.org\/10.1177\/0271678X20943823","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-05664-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-026-05664-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-05664-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T04:44:44Z","timestamp":1770007484000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-026-05664-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5664"],"URL":"https:\/\/doi.org\/10.1007\/s12035-026-05664-8","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"19 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures involving animals were conducted following approval from the Ethics Committee of the Faculty of Veterinary Medicine at Zagazig University, Egypt (approval no. ZU-IACUC\/2\/F\/33\/2025). The study adhered to the principles outlined in the U.K. Animals (Scientific Procedures) Act of 1986, the EU Directive 2010\/63\/EU on the protection of animals used for scientific purposes, and the Guide for the Care and Use of Laboratory Animals by the National Research Council. Additionally, all experimental protocols were documented according to the Animal Research: Reporting of In Vivo Experiments (ARRIVE) rules [\n                      \n                      ].","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"415"}}