{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:45:29Z","timestamp":1790765129119,"version":"4.1.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-026-05668-4","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T05:58:50Z","timestamp":1769407130000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Plumbagin Ameliorate 5-Fluorouracil-Induced Cognitive Impairment in Adult Zebrafish: In-silico and In-vivo Evidences"],"prefix":"10.1007","volume":"63","author":[{"given":"Sonima","family":"Prasad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biplob","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaunava Roy","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Rathee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charan","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arti","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"issue":"6","key":"5668_CR1","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.euf.2016.04.009","volume":"2","author":"F Joly","year":"2016","unstructured":"Joly F et al (2016) Prospective evaluation of the impact of antiangiogenic treatment on cognitive functions in metastatic renal cancer. Eur Urol Focus 2(6):642\u2013649","journal-title":"Eur Urol Focus"},{"issue":"8","key":"5668_CR2","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.3390\/molecules13081551","volume":"13","author":"N Zhang","year":"2008","unstructured":"Zhang N et al (2008) 5-Fluorouracil: mechanisms of resistance and reversal strategies. Molecules 13(8):1551\u20131569","journal-title":"Molecules"},{"issue":"2","key":"5668_CR3","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/j.1460-9568.2008.06325.x","volume":"28","author":"S Mustafa","year":"2008","unstructured":"Mustafa S et al (2008) 5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus. Eur J Neurosci 28(2):323\u2013330","journal-title":"Eur J Neurosci"},{"key":"5668_CR4","doi-asserted-by":"publisher","unstructured":"Wigmore PM, Mustafa S, El-Beltagy M, Lyons L, Umka J, Bennett G (2010) Effects of 5-FU. Adv Exp Med Biol. 2010;678:157\u2013164. https:\/\/doi.org\/10.1007\/978-1-4419-6306-2_20","DOI":"10.1007\/978-1-4419-6306-2_20"},{"key":"5668_CR5","doi-asserted-by":"publisher","first-page":"102035","DOI":"10.1016\/j.tice.2023.102035","volume":"81","author":"Y Gui","year":"2023","unstructured":"Gui Y, Famurewa AC, Olatunji OJ (2023) Naringin ameliorates 5-fluorouracil induced cardiotoxicity: an insight into its modulatory impact on oxidative stress, inflammatory and apoptotic parameters. Tissue Cell 81:102035","journal-title":"Tissue Cell"},{"key":"5668_CR6","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.neubiorev.2019.05.001","volume":"102","author":"A Matsos","year":"2019","unstructured":"Matsos A, Johnston I (2019) Chemotherapy-induced cognitive impairments: a systematic review of the animal literature. Neurosci Biobehav Rev 102:382\u2013399","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"5668_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13045-022-01313-4","volume":"15","author":"P Jin","year":"2022","unstructured":"Jin P et al (2022) Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management. J Hematol Oncol 15(1):1\u201342","journal-title":"J Hematol Oncol"},{"issue":"18","key":"5668_CR8","doi-asserted-by":"publisher","first-page":"4403","DOI":"10.3390\/cancers14184403","volume":"14","author":"R Parment","year":"2022","unstructured":"Parment R et al (2022) A Panax quinquefolius-based preparation prevents the impact of 5-FU on activity\/exploration behaviors and not on cognitive functions mitigating gut microbiota and inflammation in mice. Cancers 14(18):4403","journal-title":"Cancers"},{"issue":"6","key":"5668_CR9","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1002\/med.20235","volume":"32","author":"S Padhye","year":"2012","unstructured":"Padhye S et al (2012) Perspectives on medicinal properties of plumbagin and its analogs. Med Res Rev 32(6):1131\u20131158","journal-title":"Med Res Rev"},{"issue":"09","key":"5668_CR10","first-page":"495","volume":"65","author":"W Zhang","year":"2015","unstructured":"Zhang W et al (2015) Plumbagin protects against spinal cord injury-induced oxidative stress and inflammation in Wistar rats through Nrf-2 upregulation. Drug Res 65(09):495\u2013499","journal-title":"Drug Res"},{"issue":"6","key":"5668_CR11","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.sjbs.2017.03.006","volume":"25","author":"X-J Chen","year":"2018","unstructured":"Chen X-J, Zhang J-G, Wu L (2018) Plumbagin inhibits neuronal apoptosis, intimal hyperplasia and also suppresses TNF-\u03b1\/NF-\u03baB pathway induced inflammation and matrix metalloproteinase-2\/9 expression in rat cerebral ischemia. Saudi J Biol Sci 25(6):1033\u20131039","journal-title":"Saudi J Biol Sci"},{"key":"5668_CR12","doi-asserted-by":"publisher","first-page":"453","DOI":"10.2165\/00002512-200421070-00004","volume":"21","author":"DG Wilkinson","year":"2004","unstructured":"Wilkinson DG et al (2004) Cholinesterase inhibitors used in the treatment of Alzheimer\u2019s disease: the relationship between pharmacological effects and clinical efficacy. Drugs Aging 21:453\u2013478","journal-title":"Drugs Aging"},{"issue":"4","key":"5668_CR13","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1007\/s40520-019-01359-4","volume":"33","author":"R Benfante","year":"2021","unstructured":"Benfante R et al (2021) Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders. Aging Clin Exp Res 33(4):823\u2013834","journal-title":"Aging Clin Exp Res"},{"key":"5668_CR14","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1007\/s13311-021-01092-9","volume":"18","author":"B Ongnok","year":"2021","unstructured":"Ongnok B et al (2021) Donepezil protects against doxorubicin-induced chemobrain in rats via attenuation of inflammation and oxidative stress without interfering with doxorubicin efficacy. Neurotherapeutics 18:2107\u20132125","journal-title":"Neurotherapeutics"},{"key":"5668_CR15","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.1007\/s00213-021-05977-7","volume":"238","author":"J John","year":"2021","unstructured":"John J et al (2021) Animal models of chemotherapy-induced cognitive decline in preclinical drug development. Psychopharmacology 238:3025\u20133053","journal-title":"Psychopharmacology"},{"key":"5668_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.01.077","author":"S Arora","year":"2023","unstructured":"Arora S et al (2023) Piperine loaded metal organic frameworks reverse doxorubicin induced chemobrain in adult zebrafish. J Control Release. https:\/\/doi.org\/10.1016\/j.jconrel.2023.01.077","journal-title":"J Control Release"},{"key":"5668_CR17","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.jconrel.2023.01.077","volume":"355","author":"S Arora","year":"2023","unstructured":"Arora S et al (2023) Piperine loaded metal organic frameworks reverse doxorubicin induced chemobrain in adult zebrafish. J Control Release 355:259\u2013272","journal-title":"J Control Release"},{"key":"5668_CR18","doi-asserted-by":"publisher","first-page":"100059","DOI":"10.1016\/j.crbeha.2021.100059","volume":"2","author":"B Verma","year":"2021","unstructured":"Verma B, Singh C, Singh A (2021) Effect of hydro-alcoholic extract of Centella asiatica on streptozotocin induced memory dysfunction in adult zebrafish. Curr Res Behav Sciences 2:100059","journal-title":"Curr Res Behav Sciences"},{"issue":"4","key":"5668_CR19","doi-asserted-by":"publisher","first-page":"3247","DOI":"10.1007\/s11033-022-07161-2","volume":"49","author":"S Singh","year":"2022","unstructured":"Singh S et al (2022) Quercetin ameliorates lipopolysaccharide-induced neuroinflammation and oxidative stress in adult zebrafish. Mol Biol Rep 49(4):3247\u20133258","journal-title":"Mol Biol Rep"},{"issue":"1","key":"5668_CR20","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.bbr.2009.11.017","volume":"208","author":"M ELBeltagy","year":"2010","unstructured":"ELBeltagy M et al (2010) Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil. Behav Brain Res 208(1):112\u2013117","journal-title":"Behav Brain Res"},{"key":"5668_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2125.2004.01848.x","volume":"58","author":"S Jackson","year":"2004","unstructured":"Jackson S, Ham RJ, Wilkinson D (2004) The safety and tolerability of donepezil in patients with Alzheimer\u2019s disease. Br J Clin Pharmacol 58:1\u20138","journal-title":"Br J Clin Pharmacol"},{"key":"5668_CR22","doi-asserted-by":"publisher","first-page":"100060","DOI":"10.1016\/j.crbeha.2021.100060","volume":"2","author":"A Jangra","year":"2021","unstructured":"Jangra A et al (2021) Neuroprotective and acetylcholinesterase inhibitory activity of plumbagin in ICV-LPS induced behavioral deficits in rats. Curr Res Behav Sciences 2:100060","journal-title":"Curr Res Behav Sciences"},{"key":"5668_CR23","doi-asserted-by":"crossref","unstructured":"Rowe C et al (2021) The Three-chamber choice behavioral task using Zebrafish as a model system. J Visualized Exp: JoVE (170):e61934","DOI":"10.3791\/61934"},{"key":"5668_CR24","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.bbr.2015.09.016","volume":"296","author":"Z May","year":"2016","unstructured":"May Z et al (2016) Object recognition memory in zebrafish. Behav Brain Res 296:199\u2013210","journal-title":"Behav Brain Res"},{"issue":"7","key":"5668_CR25","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.4103\/1673-5374.211194","volume":"12","author":"S Singh","year":"2017","unstructured":"Singh S, Jamwal S, Kumar P (2017) Neuroprotective potential of Quercetin in combination with piperine against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced neurotoxicity. Neural Regen Res 12(7):1137","journal-title":"Neural Regen Res"},{"issue":"12","key":"5668_CR26","doi-asserted-by":"publisher","first-page":"8181","DOI":"10.1007\/s11033-021-06787-y","volume":"48","author":"V Kumar","year":"2021","unstructured":"Kumar V, Singh C, Singh A (2021) Zebrafish an experimental model of Huntington\u2019s disease: molecular aspects, therapeutic targets and current challenges. Mol Biol Rep 48(12):8181\u20138194. https:\/\/doi.org\/10.1007\/s11033-021-06787-y","journal-title":"Mol Biol Rep"},{"issue":"3","key":"5668_CR27","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1042\/bj0990667","volume":"99","author":"E Wills","year":"1966","unstructured":"Wills E (1966) Mechanisms of lipid peroxide formation in animal tissues. Biochem J 99(3):667","journal-title":"Biochem J"},{"issue":"2","key":"5668_CR28","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"GL Ellman","year":"1961","unstructured":"Ellman GL et al (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7(2):88\u201395","journal-title":"Biochem Pharmacol"},{"key":"5668_CR29","unstructured":"de Oliveira Vian C. Efeitos da quercetina em est\u00e1gios embrio-larvais em zebrafish (DANIO RERIO)"},{"key":"5668_CR30","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3389\/fphar.2015.00268","volume":"6","author":"A Singh","year":"2015","unstructured":"Singh A, Kumar A (2015) Microglial inhibitory mechanism of coenzyme Q10 against A\u03b2 (1-42) induced cognitive dysfunctions: possible behavioral, biochemical, cellular, and histopathological alterations. Front Pharmacol 6:268","journal-title":"Front Pharmacol"},{"issue":"1","key":"5668_CR31","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.jneumeth.2009.07.010","volume":"184","author":"A K\u00e1d\u00e1r","year":"2009","unstructured":"K\u00e1d\u00e1r A et al (2009) Improved method for combination of immunocytochemistry and Nissl staining. J Neurosci Methods 184(1):115\u2013118","journal-title":"J Neurosci Methods"},{"key":"5668_CR32","doi-asserted-by":"publisher","first-page":"100084","DOI":"10.1016\/j.crphar.2022.100084","volume":"3","author":"V Puri","year":"2022","unstructured":"Puri V et al (2022) Inhalation potential of N-Acetylcysteine loaded PLGA nanoparticles for the management of tuberculosis: in vitro lung deposition and efficacy studies. Curr Res Pharmacology and Drug Discovery 3:100084","journal-title":"Curr Res Pharmacology and Drug Discovery"},{"key":"5668_CR33","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.bbr.2016.08.039","volume":"316","author":"TR Groves","year":"2017","unstructured":"Groves TR et al (2017) 5-Fluorouracil chemotherapy upregulates cytokines and alters hippocampal dendritic complexity in aged mice. Behav Brain Res 316:215\u2013224","journal-title":"Behav Brain Res"},{"issue":"24","key":"5668_CR34","doi-asserted-by":"publisher","first-page":"12325","DOI":"10.1039\/D1FO03055H","volume":"12","author":"A Abulizi","year":"2021","unstructured":"Abulizi A et al (2021) Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice. Food Funct 12(24):12325\u201312337","journal-title":"Food Funct"},{"issue":"7","key":"5668_CR35","doi-asserted-by":"publisher","first-page":"e0180650","DOI":"10.1371\/journal.pone.0180650","volume":"12","author":"P Chaisawang","year":"2017","unstructured":"Chaisawang P et al (2017) Asiatic acid protects against cognitive deficits and reductions in cell proliferation and survival in the rat hippocampus caused by 5-fluorouracil chemotherapy. PLoS ONE 12(7):e0180650","journal-title":"PLoS ONE"},{"key":"5668_CR36","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.neuropharm.2013.11.012","volume":"79","author":"M Dubois","year":"2014","unstructured":"Dubois M et al (2014) Chemotherapy-induced long-term alteration of executive functions and hippocampal cell proliferation: role of glucose as adjuvant. Neuropharmacology 79:234\u2013248","journal-title":"Neuropharmacology"},{"key":"5668_CR37","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.bbr.2017.03.042","volume":"329","author":"MJ Sofis","year":"2017","unstructured":"Sofis MJ et al (2017) KU32 prevents 5-fluorouracil induced cognitive impairment. Behav Brain Res 329:186\u2013190","journal-title":"Behav Brain Res"},{"issue":"4","key":"5668_CR38","doi-asserted-by":"publisher","first-page":"26903","DOI":"10.31083\/JIN26903","volume":"24","author":"X Huang","year":"2025","unstructured":"Huang X et al (2025) 5-fluorouracil impairs transmission of acetylcholine in the hippocampus and induces cognitive impairments in mice. J Integr Neurosci 24(4):26903","journal-title":"J Integr Neurosci"},{"issue":"5","key":"5668_CR39","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.brainresbull.2012.05.005","volume":"88","author":"M ELBeltagy","year":"2012","unstructured":"ELBeltagy M et al (2012) The effect of 5-fluorouracil on the long term survival and proliferation of cells in the rat hippocampus. Brain Res Bull 88(5):514\u2013518","journal-title":"Brain Res Bull"},{"key":"5668_CR40","doi-asserted-by":"publisher","first-page":"114606","DOI":"10.1016\/j.biopha.2023.114606","volume":"162","author":"A Jena","year":"2023","unstructured":"Jena A et al (2023) Cellular red-ox system in health and disease: the latest update. Biomed Pharmacother 162:114606","journal-title":"Biomed Pharmacother"},{"issue":"8","key":"5668_CR41","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.neuropharm.2011.07.013","volume":"61","author":"G Winocur","year":"2011","unstructured":"Winocur G, Binns MA, Tannock I (2011) Donepezil reduces cognitive impairment associated with anti-cancer drugs in a mouse model. Neuropharmacology 61(8):1222\u20131228","journal-title":"Neuropharmacology"},{"key":"5668_CR42","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.mvr.2015.12.008","volume":"106","author":"W Li","year":"2016","unstructured":"Li W, Suwanwela NC, Patumraj S (2016) Curcumin by down-regulating NF-kB and elevating Nrf2, reduces brain edema and neurological dysfunction after cerebral I\/R. Microvasc Res 106:117\u2013127","journal-title":"Microvasc Res"},{"key":"5668_CR43","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.lfs.2018.12.018","volume":"218","author":"A Iqubal","year":"2019","unstructured":"Iqubal A et al (2019) Molecular mechanism involved in cyclophosphamide-induced cardiotoxicity: old drug with a new vision. Life Sci 218:112\u2013131","journal-title":"Life Sci"},{"issue":"1","key":"5668_CR44","first-page":"1","volume":"2","author":"T Liu","year":"2017","unstructured":"Liu T et al (2017) NF-\u03bab signaling in inflammation. Signal Transduct Target Ther 2(1):1\u20139","journal-title":"Signal Transduct Target Ther"},{"key":"5668_CR45","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.bbr.2015.06.007","volume":"292","author":"Y Kitamura","year":"2015","unstructured":"Kitamura Y et al (2015) Doxorubicin and cyclophosphamide treatment produces anxiety-like behavior and spatial cognition impairment in rats: possible involvement of hippocampal neurogenesis via brain-derived neurotrophic factor and cyclin D1 regulation. Behav Brain Res 292:184\u2013193","journal-title":"Behav Brain Res"},{"key":"5668_CR46","doi-asserted-by":"publisher","unstructured":"Sharma S et al (2018) Prophylactic treatment with icariin prevents isoproterenol-induced myocardial oxidative stress via nuclear factor-like 2 activation. Pharmacogn Mag 14. https:\/\/doi.org\/10.4103\/pm.pm","DOI":"10.4103\/pm.pm"},{"issue":"1","key":"5668_CR47","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/fcp.12166","volume":"30","author":"DV Fons\u00eaca","year":"2016","unstructured":"Fons\u00eaca DV et al (2016) Nerolidol exhibits antinociceptive and anti-inflammatory activity: involvement of the GABA ergic system and proinflammatory cytokines. Fundam Clin Pharmacol 30(1):14\u201322","journal-title":"Fundam Clin Pharmacol"},{"issue":"1","key":"5668_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12868-016-0293-4","volume":"17","author":"H Javed","year":"2016","unstructured":"Javed H et al (2016) Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone. BMC Neurosci 17(1):1\u201312","journal-title":"BMC Neurosci"},{"issue":"1","key":"5668_CR49","doi-asserted-by":"publisher","first-page":"60","DOI":"10.2174\/138945008783431718","volume":"9","author":"NE Cameron","year":"2008","unstructured":"Cameron NE, Cotter MA (2008) Pro-inflammatory mechanisms in diabetic neuropathy: focus on the nuclear factor kappa B pathway. Curr Drug Targets 9(1):60\u201367","journal-title":"Curr Drug Targets"},{"key":"5668_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119647","author":"J Wautier","year":"2023","unstructured":"Wautier J, Wautier M (2023) Pro- and anti-inflammatory prostaglandins and cytokines in humans: a mini review. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms24119647","journal-title":"Int J Mol Sci"},{"key":"5668_CR51","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s12640-015-9590-4","volume":"30","author":"S Almeida","year":"2016","unstructured":"Almeida S et al (2016) Are polyphenols strong dietary agents against neurotoxicity and neurodegeneration? Neurotox Res 30:345\u2013366","journal-title":"Neurotox Res"},{"key":"5668_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103117","author":"C Patibandla","year":"2024","unstructured":"Patibandla C et al (2024) Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells. Redox Biol. https:\/\/doi.org\/10.1016\/j.redox.2024.103117","journal-title":"Redox Biol"},{"key":"5668_CR53","doi-asserted-by":"publisher","first-page":"101059","DOI":"10.1016\/j.redox.2018.11.017","volume":"21","author":"F Sivandzade","year":"2019","unstructured":"Sivandzade F et al (2019) NRF2 and NF-\u049bB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches. Redox Biol 21:101059","journal-title":"Redox Biol"},{"key":"5668_CR54","doi-asserted-by":"publisher","unstructured":"Torre M, Zanella C, Feany M (2025) The biological intersection between chemotherapy-related cognitive impairment and Alzheimer's disease. Am J Pathol. https:\/\/doi.org\/10.1016\/j.ajpath.2024.12.013","DOI":"10.1016\/j.ajpath.2024.12.013"},{"issue":"1","key":"5668_CR55","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/jso.2930420108","volume":"42","author":"A Suto","year":"1989","unstructured":"Suto A et al (1989) MTT assay with reference to the clinical effect of chemotherapy. J Surg Oncol 42(1):28\u201332","journal-title":"J Surg Oncol"},{"key":"5668_CR56","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2023-2694","author":"M Rashid","year":"2023","unstructured":"Rashid M et al (2023) Abstract 2694: blockade of the cyclooxygenase-2 prevents chemotherapy-induced cognitive impairments. Cancer Res. https:\/\/doi.org\/10.1158\/1538-7445.AM2023-2694","journal-title":"Cancer Res"},{"issue":"10","key":"5668_CR57","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1016\/j.ejca.2010.02.021","volume":"46","author":"J Li","year":"2010","unstructured":"Li J et al (2010) Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. Eur J Cancer 46(10):1900\u20131909","journal-title":"Eur J Cancer"},{"key":"5668_CR58","doi-asserted-by":"crossref","unstructured":"Tambe P et al (2025) Targeted modulation of mitochondrial oxidative stress ameliorates 5-fluorouracil-induced renal injury in BALB\/c Mice. Oxidative Medi Cell Longev 2025(1):8892026","DOI":"10.1155\/omcl\/8892026"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-05668-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-026-05668-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-05668-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:02:29Z","timestamp":1769410949000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-026-05668-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5668"],"URL":"https:\/\/doi.org\/10.1007\/s12035-026-05668-4","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"9 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Institutional Biosafety committee (IBSC) with approval number ISFCP\/IBSC\/M3\/2022\/33.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal Approval Number"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical Trial Number"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interest"}}],"article-number":"395"}}