{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:03:57Z","timestamp":1777982637209,"version":"3.51.4"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82474428"],"award-info":[{"award-number":["82474428"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82174348"],"award-info":[{"award-number":["82174348"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["No.SZZYSM202411012"],"award-info":[{"award-number":["No.SZZYSM202411012"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1801102"],"award-info":[{"award-number":["2022YFD1801102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-026-05876-y","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T11:10:24Z","timestamp":1776856224000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salvianolic Acid B Inhibits Ferroptosis Through ACSL4 Pathway Regulation in sepsis-associated encephalopathy Mice"],"prefix":"10.1007","volume":"63","author":[{"given":"Xingyao","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhizhun","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingquan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"5876_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M et al (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315:801\u2013810. https:\/\/doi.org\/10.1001\/jama.2016.0287","journal-title":"JAMA"},{"key":"5876_CR2","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nrneurol.2012.183","volume":"8","author":"TE Gofton","year":"2012","unstructured":"Gofton TE, Young GB (2012) Sepsis-associated encephalopathy. Nat Rev Neurol 8:557\u2013566. https:\/\/doi.org\/10.1038\/nrneurol.2012.183","journal-title":"Nat Rev Neurol"},{"key":"5876_CR3","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1007\/s13311-020-00862-1","volume":"17","author":"A Mazeraud","year":"2020","unstructured":"Mazeraud A, Righy C, Bouchereau E, Benghanem S, Bozza FA, Sharshar T (2020) Septic-associated encephalopathy: a comprehensive review. Neurotherapeutics 17:392\u2013403. https:\/\/doi.org\/10.1007\/s13311-020-00862-1","journal-title":"Neurotherapeutics"},{"key":"5876_CR4","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1097\/hm9.0000000000000166","volume":"5","author":"C Lujia","year":"2025","unstructured":"Lujia C, Xiaolei W, Chenyao Z, Chuanchi W, Wenliang L, Li L et al (2025) Short-term post-COVID-19 symptoms in 21,012 patients: a cross-sectional study. Acupunct Herb Med 5:291\u2013300. https:\/\/doi.org\/10.1097\/hm9.0000000000000166","journal-title":"Acupunct Herb Med"},{"key":"5876_CR5","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1134\/S0006297921020048","volume":"86","author":"AP Bolshakov","year":"2021","unstructured":"Bolshakov AP, Tret\u2019yakova LV, Kvichansky AA, Gulyaeva NV (2021) Glucocorticoids: Dr. jekyll and Mr. hyde of hippocampal neuroinflammation. Biochemistry (Mosc) 86:156\u2013167. https:\/\/doi.org\/10.1134\/S0006297921020048","journal-title":"Biochemistry (Mosc)"},{"key":"5876_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113331","volume":"143","author":"H Duan","year":"2024","unstructured":"Duan H, Yang X, Cai S, Zhang L, Qiu Z, Wang J et al (2024) Nrf2 mitigates sepsis-associated encephalopathy-induced hippocampus ferroptosis via modulating mitochondrial dynamic homeostasis. Int Immunopharmacol 143:113331. https:\/\/doi.org\/10.1016\/j.intimp.2024.113331","journal-title":"Int Immunopharmacol"},{"key":"5876_CR7","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1111\/cns.13973","volume":"28","author":"C Li","year":"2022","unstructured":"Li C, Wu Z, Xue H, Gao Q, Zhang Y, Wang C et al (2022) Ferroptosis contributes to hypoxic-ischemic brain injury in neonatal rats: role of the SIRT1\/Nrf2\/GPx4 signaling pathway. CNS Neurosci Ther 28:2268\u20132280. https:\/\/doi.org\/10.1111\/cns.13973","journal-title":"CNS Neurosci Ther"},{"key":"5876_CR8","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1097\/SHK.0000000000001893","volume":"57","author":"Z Xie","year":"2022","unstructured":"Xie Z, Xu M, Xie J, Liu T, Xu X, Gao W et al (2022) Inhibition of ferroptosis attenuates glutamate excitotoxicity and nuclear autophagy in a CLP septic mouse model. Shock 57:694\u2013702. https:\/\/doi.org\/10.1097\/SHK.0000000000001893","journal-title":"Shock"},{"key":"5876_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.1032140","volume":"16","author":"Y Li","year":"2022","unstructured":"Li Y, Xiao D, Wang X (2022) The emerging roles of ferroptosis in cells of the central nervous system. Front Neurosci 16:1032140. https:\/\/doi.org\/10.3389\/fnins.2022.1032140","journal-title":"Front Neurosci"},{"key":"5876_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155384","volume":"128","author":"L Deng","year":"2024","unstructured":"Deng L, Tian W, Luo L (2024) Application of natural products in regulating ferroptosis in human diseases. Phytomedicine 128:155384. https:\/\/doi.org\/10.1016\/j.phymed.2024.155384","journal-title":"Phytomedicine"},{"key":"5876_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-024-02116-x","volume":"23","author":"H Wang","year":"2024","unstructured":"Wang H, Xu L, Tang X, Jiang Z, Feng X (2024) Lipid peroxidation-induced ferroptosis as a therapeutic target for mitigating neuronal injury and inflammation in sepsis-associated encephalopathy: insights into the hippocampal PEBP-1\/15-LOX\/GPX4 pathway. Lipids Health Dis 23:128. https:\/\/doi.org\/10.1186\/s12944-024-02116-x","journal-title":"Lipids Health Dis"},{"key":"5876_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.156078","volume":"161","author":"J Wang","year":"2023","unstructured":"Wang J, Yang S, Jing G, Wang Q, Zeng C, Song X et al (2023) Inhibition of ferroptosis protects sepsis-associated encephalopathy. Cytokine 161:156078. https:\/\/doi.org\/10.1016\/j.cyto.2022.156078","journal-title":"Cytokine"},{"key":"5876_CR13","doi-asserted-by":"publisher","first-page":"4677","DOI":"10.1007\/s12035-023-03870-2","volume":"61","author":"Y Liu","year":"2024","unstructured":"Liu Y, Hu S, Shi B, Yu B, Luo W, Peng S et al (2024) The role of iron metabolism in sepsis-associated encephalopathy: a potential target. Mol Neurobiol 61:4677\u20134690. https:\/\/doi.org\/10.1007\/s12035-023-03870-2","journal-title":"Mol Neurobiol"},{"key":"5876_CR14","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1097\/hm9.0000000000000120","volume":"4","author":"Z Zihao","year":"2024","unstructured":"Zihao Z, Yan W, Zhengzheng D, Pengyuan L, Qi L, Jingjing G et al (2024) The Hemerocallis citrina extracts ameliorate radiation-induced ferroptosis in LO2 cells through the Nrf2-xCT\/GPX4 pathway. Acupunct Herb Med 4:513\u2013524. https:\/\/doi.org\/10.1097\/hm9.0000000000000120","journal-title":"Acupunct Herb Med"},{"key":"5876_CR15","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1007\/s12035-022-02738-1","volume":"59","author":"XB Wei","year":"2022","unstructured":"Wei XB, Jiang WQ, Zeng JH, Huang LQ, Ding HG, Jing YW et al (2022) Exosome-derived lncRNA NEAT1 exacerbates sepsis-associated encephalopathy by promoting ferroptosis through regulating miR-9-5p\/TFRC and GOT1 axis. Mol Neurobiol 59:1954\u20131969. https:\/\/doi.org\/10.1007\/s12035-022-02738-1","journal-title":"Mol Neurobiol"},{"key":"5876_CR16","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70156","volume":"28","author":"X Yang","year":"2024","unstructured":"Yang X, Duan H, Li S, Zhang J, Dong L, Ding J et al (2024) Yap1 alleviates sepsis associated encephalopathy by inhibiting hippocampus ferroptosis via maintaining mitochondrial dynamic homeostasis. J Cell Mol Med 28:e70156. https:\/\/doi.org\/10.1111\/jcmm.70156","journal-title":"J Cell Mol Med"},{"key":"5876_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2025.115305","volume":"391","author":"D Wang","year":"2025","unstructured":"Wang D, Geng Y, Gu F, Zhuang Y, Lv H, He X et al (2025) Salvianolic acid B exerts cerebroprotective effects after traumatic brain injury via Nrf2-dependent antioxidant and anti-inflammatory cascades. Exp Neurol 391:115305. https:\/\/doi.org\/10.1016\/j.expneurol.2025.115305","journal-title":"Exp Neurol"},{"key":"5876_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155676","volume":"130","author":"JM Sun","year":"2024","unstructured":"Sun JM, Liu YX, Liu YD, Ho CK, Tsai YT, Wen DS et al (2024) Salvianolic acid B protects against UVB-induced skin aging via activation of NRF2. Phytomedicine 130:155676. https:\/\/doi.org\/10.1016\/j.phymed.2024.155676","journal-title":"Phytomedicine"},{"key":"5876_CR19","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s11655-011-0877-x","volume":"17","author":"J Wang","year":"2011","unstructured":"Wang J, Zhang Y, Guo LL, Wu GJ, Liu RH (2011) Salvianolic acid B inhibits the TLR4-NFkappaB-TNFalpha pathway and attenuates neonatal rat cardiomyocyte injury induced by lipopolysaccharide. Chin J Integr Med 17:775\u2013779. https:\/\/doi.org\/10.1007\/s11655-011-0877-x","journal-title":"Chin J Integr Med"},{"key":"5876_CR20","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1080\/13880209.2022.2096644","volume":"60","author":"B Lu","year":"2022","unstructured":"Lu B, Li J, Gui M, Yao L, Fan M, Zhou X et al (2022) Salvianolic acid B inhibits myocardial I\/R-induced ROS generation and cell apoptosis by regulating the TRIM8\/GPX1 pathway. Pharm Biol 60:1458\u20131468. https:\/\/doi.org\/10.1080\/13880209.2022.2096644","journal-title":"Pharm Biol"},{"key":"5876_CR21","doi-asserted-by":"publisher","first-page":"3364","DOI":"10.1002\/jsfa.14106","volume":"105","author":"Y Xie","year":"2025","unstructured":"Xie Y, Zhang Z, Liu Z, Zhao Z, Yang R (2025) Salvianolic acid B influences the ferritin function in iron(II)\/iron(III) transformation and iron chelation. J Sci Food Agric 105:3364\u20133372. https:\/\/doi.org\/10.1002\/jsfa.14106","journal-title":"J Sci Food Agric"},{"key":"5876_CR22","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1128\/IAI.69.4.2099-2106.2001","volume":"69","author":"SJ Ebong","year":"2001","unstructured":"Ebong SJ, Goyert SM, Nemzek JA, Kim J, Bolgos GL, Remick DG (2001) Critical role of CD14 for production of proinflammatory cytokines and cytokine inhibitors during sepsis with failure to alter morbidity or mortality. Infect Immun 69:2099\u20132106. https:\/\/doi.org\/10.1128\/IAI.69.4.2099-2106.2001","journal-title":"Infect Immun"},{"key":"5876_CR23","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.bbi.2017.07.012","volume":"66","author":"J Zhang","year":"2017","unstructured":"Zhang J, Xie X, Tang M, Zhang J, Zhang B, Zhao Q et al (2017) Salvianolic acid B promotes microglial M2-polarization and rescues neurogenesis in stress-exposed mice. Brain Behav Immun 66:111\u2013124. https:\/\/doi.org\/10.1016\/j.bbi.2017.07.012","journal-title":"Brain Behav Immun"},{"key":"5876_CR24","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.lfs.2012.05.021","volume":"90","author":"Y Feng","year":"2012","unstructured":"Feng Y, You Z, Yan S, He G, Chen Y, Gou X et al (2012) Antidepressant-like effects of salvianolic acid B in the mouse forced swim and tail suspension tests. Life Sci 90:1010\u20131014. https:\/\/doi.org\/10.1016\/j.lfs.2012.05.021","journal-title":"Life Sci"},{"key":"5876_CR25","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5146982","volume":"2020","author":"Z Qiang","year":"2020","unstructured":"Qiang Z, Dong H, Xia Y, Chai D, Hu R, Jiang H (2020) Nrf2 and STAT3 alleviates ferroptosis-mediated IIR-ALI by regulating SLC7A11. Oxid Med Cell Longev 2020:5146982. https:\/\/doi.org\/10.1155\/2020\/5146982","journal-title":"Oxid Med Cell Longev"},{"key":"5876_CR26","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-233","volume":"7","author":"B Shrum","year":"2014","unstructured":"Shrum B, Anantha RV, Xu SX, Donnelly M, Haeryfar SM, McCormick JK et al (2014) A robust scoring system to evaluate sepsis severity in an animal model. BMC Res Notes 7:233. https:\/\/doi.org\/10.1186\/1756-0500-7-233","journal-title":"BMC Res Notes"},{"key":"5876_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117301","volume":"178","author":"X Wang","year":"2024","unstructured":"Wang X, Qian J, Li Y, Meng Y, Cheng R, Ren N et al (2024) Protective effects of forsythoside A against severe acute pancreatitis- induced brain injury in mice. Biomed Pharmacother 178:117301. https:\/\/doi.org\/10.1016\/j.biopha.2024.117301","journal-title":"Biomed Pharmacother"},{"key":"5876_CR28","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/978-1-4939-8994-2_10","volume":"1916","author":"AK Kraeuter","year":"2019","unstructured":"Kraeuter AK, Guest PC, Sarnyai Z (2019) The Y-maze for assessment of spatial working and reference memory in mice. Methods Mol Biol 1916:105\u2013111. https:\/\/doi.org\/10.1007\/978-1-4939-8994-2_10","journal-title":"Methods Mol Biol"},{"key":"5876_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.117152","volume":"283","author":"Y Wang","year":"2025","unstructured":"Wang Y, Wang W, Zhang Y, Fleishman JS, Wang H (2025) Targeting ferroptosis offers therapy choice in sepsis-associated acute lung injury. Eur J Med Chem 283:117152. https:\/\/doi.org\/10.1016\/j.ejmech.2024.117152","journal-title":"Eur J Med Chem"},{"key":"5876_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103194","volume":"74","author":"D Wu","year":"2024","unstructured":"Wu D, Spencer CB, Ortoga L, Zhang H, Miao C (2024) Histone lactylation-regulated METTL3 promotes ferroptosis via m6A-modification on ACSL4 in sepsis-associated lung injury. Redox Biol 74:103194. https:\/\/doi.org\/10.1016\/j.redox.2024.103194","journal-title":"Redox Biol"},{"key":"5876_CR31","unstructured":"Yao Y, Sheng Z (2008) Prevention and management of sepsis. Scientific and Technical Documentation Press, Beijing"},{"key":"5876_CR32","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1590\/S0004-2803.201800000-29","volume":"55","author":"DV Bavaresco","year":"2018","unstructured":"Bavaresco DV, Schwalm MT, Farias BM, Ceretta LB, Rosa MID, Valvassori SS (2018) Increased oxidative stress in the blood of ostomy patients. Arq Gastroenterol 55:164\u2013169. https:\/\/doi.org\/10.1590\/S0004-2803.201800000-29","journal-title":"Arq Gastroenterol"},{"key":"5876_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/2045-9912-1-7","volume":"1","author":"JM Eckermann","year":"2011","unstructured":"Eckermann JM, Chen W, Jadhav V, Hsu FP, Colohan AR, Tang J et al (2011) Hydrogen is neuroprotective against surgically induced brain injury. Med Gas Res 1:7. https:\/\/doi.org\/10.1186\/2045-9912-1-7","journal-title":"Med Gas Res"},{"key":"5876_CR34","doi-asserted-by":"publisher","first-page":"626","DOI":"10.7644\/j.issn.1674-9960.2023.08.012","volume":"47","author":"Y Shi","year":"2023","unstructured":"Shi Y, Niu W, Yuan X (2023) Research progress in mechanism and treatment of cytokine storm in sepsis. Mil Med Sci 47:626\u2013630. https:\/\/doi.org\/10.7644\/j.issn.1674-9960.2023.08.012","journal-title":"Mil Med Sci"},{"key":"5876_CR35","doi-asserted-by":"publisher","first-page":"000","DOI":"10.14218\/fim.2024.00040","volume":"000","author":"J Zhang","year":"2025","unstructured":"Zhang J, Jiang Y, Zhu R, Wang K, Li W, Wang C et al (2025) Effects of shenfu decoction on neutrophil chemotactic function in septic mice. Future Integr Med 000:000\u2013000. https:\/\/doi.org\/10.14218\/fim.2024.00040","journal-title":"Future Integr Med"},{"key":"5876_CR36","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5405104","volume":"2017","author":"H Xu","year":"2017","unstructured":"Xu H, Wang Z, Li J, Wu H, Peng Y, Fan L et al (2017) The polarization states of microglia in TBI: a new paradigm for pharmacological intervention. Neural Plast 2017:5405104. https:\/\/doi.org\/10.1155\/2017\/5405104","journal-title":"Neural Plast"},{"key":"5876_CR37","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.cmi.2016.09.013","volume":"22","author":"T Xia","year":"2016","unstructured":"Xia T, Xu X, Zhao N, Luo Z, Tang Y (2016) Comparison of the diagnostic power of cytokine patterns and procalcitonin for predicting infection among paediatric haematology\/oncology patients. Clin Microbiol Infect 22:996\u20131001. https:\/\/doi.org\/10.1016\/j.cmi.2016.09.013","journal-title":"Clin Microbiol Infect"},{"key":"5876_CR38","first-page":"502","volume":"31","author":"F Luo","year":"2021","unstructured":"Luo F, Hua W, Qian M, Pan W, Huang W (2021) T lymphocyte subsets and Th1\/Th2 cytokine profile in the early identification of bacteria in urinary sepsis. Chin J Nosocomiol 31:502\u2013506","journal-title":"Chin J Nosocomiol"},{"key":"5876_CR39","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1097\/00004691-199204010-00006","volume":"9","author":"WD Knowles","year":"1992","unstructured":"Knowles WD (1992) Normal anatomy and neurophysiology of the hippocampal formation. J Clin Neurophysiol 9:252\u2013263","journal-title":"J Clin Neurophysiol"},{"key":"5876_CR40","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/s0896-6273(00)80987-3","volume":"20","author":"B Milner","year":"1998","unstructured":"Milner B, Squire LR, Kandel ER (1998) Cognitive neuroscience and the study of memory. Neuron 20:445\u2013468. https:\/\/doi.org\/10.1016\/s0896-6273(00)80987-3","journal-title":"Neuron"},{"key":"5876_CR41","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.25276","volume":"102","author":"AM Einenkel","year":"2024","unstructured":"Einenkel AM, Salameh A (2024) Selective vulnerability of hippocampal CA1 and CA3 pyramidal cells: what are possible pathomechanisms and should more attention be paid to the CA3 region in future studies? J Neurosci Res 102:e25276. https:\/\/doi.org\/10.1002\/jnr.25276","journal-title":"J Neurosci Res"},{"key":"5876_CR42","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/s41583-020-0362-7","volume":"21","author":"LR Taxier","year":"2020","unstructured":"Taxier LR, Gross KS, Frick KM (2020) Oestradiol as a neuromodulator of learning and memory. Nat Rev Neurosci 21:535\u2013550. https:\/\/doi.org\/10.1038\/s41583-020-0362-7","journal-title":"Nat Rev Neurosci"},{"key":"5876_CR43","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/s42255-022-00594-w","volume":"4","author":"G Pekkurnaz","year":"2022","unstructured":"Pekkurnaz G, Wang X (2022) Mitochondrial heterogeneity and homeostasis through the lens of a neuron. Nat Metab 4:802\u2013812. https:\/\/doi.org\/10.1038\/s42255-022-00594-w","journal-title":"Nat Metab"},{"key":"5876_CR44","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1093\/cercor\/bhs139","volume":"23","author":"KM Rodrigue","year":"2013","unstructured":"Rodrigue KM, Daugherty AM, Haacke EM, Raz N (2013) The role of hippocampal iron concentration and hippocampal volume in age-related differences in memory. Cereb Cortex 23:1533\u20131541. https:\/\/doi.org\/10.1093\/cercor\/bhs139","journal-title":"Cereb Cortex"},{"key":"5876_CR45","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nchembio.2239","volume":"13","author":"S Doll","year":"2017","unstructured":"Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I et al (2017) ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol 13:91\u201398. https:\/\/doi.org\/10.1038\/nchembio.2239","journal-title":"Nat Chem Biol"},{"key":"5876_CR46","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41556-021-00818-3","volume":"24","author":"HL Zhang","year":"2022","unstructured":"Zhang HL, Hu BX, Li ZL, Du T, Shan JL, Ye ZP et al (2022) <article-title update=\"added\">PKC\u03b2II phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis. Nat Cell Biol 24:88\u201398. https:\/\/doi.org\/10.1038\/s41556-021-00818-3","journal-title":"Nat Cell Biol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-05876-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-026-05876-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-05876-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T11:10:30Z","timestamp":1776856230000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-026-05876-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5876"],"URL":"https:\/\/doi.org\/10.1007\/s12035-026-05876-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7925353\/v1","asserted-by":"object"}]},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"22 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"581"}}