{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:03:37Z","timestamp":1791407017331,"version":"4.3.3"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-026-05899-5","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:07:55Z","timestamp":1779354475000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Upregulation of the Mitophagy-Related Gene EXOSC4 Is Associated with Immune Dysregulation in Spinal Cord Injury"],"prefix":"10.1007","volume":"63","author":[{"given":"Xiaoqin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MengFan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiating","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PanFeng","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"5899_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1517871","volume":"12","author":"H Qin","year":"2024","unstructured":"Qin H et al (2024) Analysis and comparison of the trends in burden of spinal cord injury in China and worldwide from 1990 to 2021: an analysis of the global burden of disease study 2021. Front Public Health 12:p. 1517871","journal-title":"Front Public Health"},{"issue":"5","key":"5899_CR2","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/s41393-017-0038-y","volume":"56","author":"WB McKay","year":"2018","unstructured":"McKay WB, Sweatman WM, Field-Fote EC (2018) The experience of spasticity after spinal cord injury: perceived characteristics and impact on daily life. Spinal Cord 56(5):478\u2013486","journal-title":"Spinal Cord"},{"issue":"4","key":"5899_CR3","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1159\/000524867","volume":"56","author":"A Golestani","year":"2022","unstructured":"Golestani A et al (2022) Epidemiology of traumatic spinal cord injury in developing countries from 2009 to 2020: a systematic review and meta-analysis. Neuroepidemiology 56(4):219\u2013239","journal-title":"Neuroepidemiology"},{"issue":"1","key":"5899_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03514-9","volume":"22","author":"Y Lu","year":"2024","unstructured":"Lu Y et al (2024) Global incidence and characteristics of spinal cord injury since 2000-2021: a systematic review and meta-analysis. BMC Med 22(1):285","journal-title":"BMC Med"},{"key":"5899_CR5","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jare.2023.06.010","volume":"59","author":"X Xu","year":"2024","unstructured":"Xu X et al (2024) Autophagy, a double-edged sword for oral tissue regeneration. J Adv Res 59:141\u2013159","journal-title":"J Adv Res"},{"issue":"1","key":"5899_CR6","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s10020-024-00903-x","volume":"30","author":"L Zhu","year":"2024","unstructured":"Zhu L, Xu Y, Lei J (2024) Molecular mechanism and potential role of mitophagy in acute pancreatitis. Mol Med 30(1):136","journal-title":"Mol Med"},{"issue":"1","key":"5899_CR7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/cdd.2012.81","volume":"20","author":"G Ashrafi","year":"2013","unstructured":"Ashrafi G, Schwarz TL (2013) The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ 20(1):31\u201342","journal-title":"Cell Death Differ"},{"issue":"2","key":"5899_CR8","doi-asserted-by":"publisher","first-page":"736","DOI":"10.7150\/thno.79876","volume":"13","author":"Y Lu","year":"2023","unstructured":"Lu Y et al (2023) Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation. Theranostics 13(2):736\u2013766","journal-title":"Theranostics"},{"issue":"3","key":"5899_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202407757","volume":"12","author":"Z Tian","year":"2025","unstructured":"Tian Z et al (2025) Self-healing COCu-Tac hydrogel enhances iNSCs transplantation for spinal cord injury by promoting mitophagy via the FKBP52\/AKT pathway. Adv Sci (Weinh) 12(3):e2407757","journal-title":"Adv Sci (Weinh)"},{"key":"5899_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102987","volume":"114","author":"S Hu","year":"2026","unstructured":"Hu S et al (2026) Mitochondrial dynamics in neurodegenerative diseases: research hotspots and trends from 2005 to 2025. Ageing Res Rev 114:102987","journal-title":"Ageing Res Rev"},{"issue":"1","key":"5899_CR11","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.molmed.2019.07.002","volume":"26","author":"G Lou","year":"2020","unstructured":"Lou G et al (2020) Mitophagy and neuroprotection. Trends Mol Med 26(1):8\u201320","journal-title":"Trends Mol Med"},{"issue":"9-10","key":"5899_CR12","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1007\/s10495-024-01977-y","volume":"29","author":"MS D'Arcy","year":"2024","unstructured":"D\u2019Arcy MS (2024) Mitophagy in health and disease. Molecular mechanisms, regulatory pathways, and therapeutic implications. Apoptosis 29(9\u201310):1415\u20131428","journal-title":"Apoptosis"},{"key":"5899_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105240","volume":"163","author":"X Li","year":"2021","unstructured":"Li X et al (2021) Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases. Pharmacol Res 163:105240","journal-title":"Pharmacol Res"},{"issue":"9","key":"5899_CR14","doi-asserted-by":"publisher","first-page":"4188","DOI":"10.7150\/thno.109071","volume":"15","author":"M Xia","year":"2025","unstructured":"Xia M et al (2025) Activation of FANCC attenuates mitochondrial ROS-driven necroptosis by targeting TBK1-dependent mitophagy in astrocytes after spinal cord injury. Theranostics 15(9):4188\u20134211","journal-title":"Theranostics"},{"issue":"4","key":"5899_CR15","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.4103\/NRR.NRR-D-24-01029","volume":"21","author":"Q Gu","year":"2026","unstructured":"Gu Q et al (2026) Mitophagy: a key regulator in the pathophysiology and treatment of spinal cord injury. Neural Regen Res 21(4):1396\u20131408","journal-title":"Neural Regen Res"},{"key":"5899_CR16","doi-asserted-by":"publisher","first-page":"1.30.1","DOI":"10.1002\/cpbi.5","volume":"54","author":"G Stelzer","year":"2016","unstructured":"Stelzer G et al (2016) The GeneCards suite: from gene data mining to disease genome sequence analyses. Curr Protoc Bioinformatics 54:1.30.1-1.30.33","journal-title":"Curr Protoc Bioinformatics"},{"issue":"10","key":"5899_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/psp.2013.56","volume":"2","author":"K Ito","year":"2013","unstructured":"Ito K, Murphy D (2013) Application of ggplot2 to pharmacometric graphics. CPT Pharmacomet Syst Pharmacol 2(10):e79","journal-title":"CPT Pharmacomet Syst Pharmacol"},{"key":"5899_CR18","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9:559","journal-title":"BMC Bioinformatics"},{"issue":"8","key":"5899_CR19","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1007\/s11136-024-03650-y","volume":"33","author":"A Daoud","year":"2024","unstructured":"Daoud A et al (2024) Predictive factors and quality of life assessment among patients with spinal cord injury in the Middle East: a systematic review. Qual Life Res 33(8):2081\u20132094","journal-title":"Qual Life Res"},{"key":"5899_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207533","author":"A Anjum","year":"2020","unstructured":"Anjum A et al (2020) Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21207533","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5899_CR21","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41392-023-01477-6","volume":"8","author":"X Hu","year":"2023","unstructured":"Hu X et al (2023) Spinal cord injury: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther 8(1):245","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"5899_CR22","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1503\/cmaj.121206","volume":"185","author":"JR Wilson","year":"2013","unstructured":"Wilson JR, Forgione N, Fehlings MG (2013) Emerging therapies for acute traumatic spinal cord injury. CMAJ 185(6):485\u2013492","journal-title":"CMAJ"},{"key":"5899_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103200","author":"P Jendelova","year":"2018","unstructured":"Jendelova P (2018) Therapeutic strategies for spinal cord injury. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms19103200","journal-title":"Int J Mol Sci"},{"key":"5899_CR24","first-page":"370","volume":"59","author":"Y Luo","year":"2026","unstructured":"Luo Y et al (2026) Synergistic mitochondrial homeostasis regulation and cholinergic circuits reconstruction via a one-step synthesized multifunctional hydrogel facilitates spinal cord injury repair. Bioact Mater 59:370\u2013395","journal-title":"Bioact Mater"},{"issue":"9","key":"5899_CR25","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/s41556-018-0176-2","volume":"20","author":"K Palikaras","year":"2018","unstructured":"Palikaras K, Lionaki E, Tavernarakis N (2018) Mechanisms of mitophagy in cellular homeostasis, physiology and pathology. Nat Cell Biol 20(9):1013\u20131022","journal-title":"Nat Cell Biol"},{"issue":"11","key":"5899_CR26","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1016\/j.cmet.2022.10.008","volume":"34","author":"M Picard","year":"2022","unstructured":"Picard M, Shirihai OS (2022) Mitochondrial signal transduction. Cell Metab 34(11):1620\u20131653","journal-title":"Cell Metab"},{"key":"5899_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.812340","volume":"10","author":"H Wang","year":"2022","unstructured":"Wang H et al (2022) Reverse adverse immune microenvironments by biomaterials enhance the repair of spinal cord injury. Front Bioeng Biotechnol 10:812340","journal-title":"Front Bioeng Biotechnol"},{"issue":"11","key":"5899_CR28","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18408","volume":"28","author":"P Zhang","year":"2024","unstructured":"Zhang P et al (2024) Deciphering lung adenocarcinoma evolution: integrative single-cell genomics identifies the prognostic lung progression associated signature. J Cell Mol Med 28(11):e18408","journal-title":"J Cell Mol Med"},{"issue":"1","key":"5899_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-025-02172-2","volume":"8","author":"Z Gong","year":"2025","unstructured":"Gong Z et al (2025) Machine learning identifies TIME subtypes linking EGFR mutations and immune states in lung adenocarcinoma. npj Digit Med 8(1):796","journal-title":"npj Digit Med"},{"issue":"6","key":"5899_CR30","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.21147\/j.issn.1000-9604.2025.06.11","volume":"37","author":"P Zhang","year":"2025","unstructured":"Zhang P et al (2025) Metabolic reprogramming signature predicts immunotherapy efficacy in lung adenocarcinoma: targeting SLC25A1 to overcome immune resistance. Chin J Cancer Res 37(6):1000\u20131019","journal-title":"Chin J Cancer Res"},{"issue":"10","key":"5899_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2005264","volume":"16","author":"AD Greenhalgh","year":"2018","unstructured":"Greenhalgh AD et al (2018) Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury. PLoS Biol 16(10):e2005264","journal-title":"PLoS Biol"},{"issue":"2","key":"5899_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113753","volume":"43","author":"Y Huang","year":"2024","unstructured":"Huang Y et al (2024) Schwann cell promotes macrophage recruitment through IL-17B\/IL-17RB pathway in injured peripheral nerves. Cell Rep 43(2):113753","journal-title":"Cell Rep"},{"key":"5899_CR33","first-page":"10","volume":"29","author":"Y Lu","year":"2025","unstructured":"Lu Y, Yin H, Lou L, Liu Z, Zhu H, Gu C, Zhang C, Wang J (2025Sep) M2 polarization of macrophages: Manipulation of spinal cord injury repair. Neural Regeneration Research. 29:10\u20134103","journal-title":"Neural Regeneration Research."},{"issue":"4","key":"5899_CR34","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s12975-011-0109-x","volume":"2","author":"MT Ng","year":"2011","unstructured":"Ng MT, Stammers AT, Kwon BK (2011) Vascular disruption and the role of angiogenic proteins after spinal cord injury. Transl Stroke Res 2(4):474\u2013491","journal-title":"Transl Stroke Res"},{"issue":"2","key":"5899_CR35","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/jnr.10759","volume":"74","author":"WD Whetstone","year":"2003","unstructured":"Whetstone WD et al (2003) Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J Neurosci Res 74(2):227\u2013239","journal-title":"J Neurosci Res"},{"key":"5899_CR36","doi-asserted-by":"publisher","first-page":"17018","DOI":"10.1038\/nrdp.2017.18","volume":"3","author":"CS Ahuja","year":"2017","unstructured":"Ahuja CS et al (2017) Traumatic spinal cord injury. Nat Rev Dis Primers 3:17018","journal-title":"Nat Rev Dis Primers"},{"issue":"9","key":"5899_CR37","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1089\/neu.2020.7413","volume":"38","author":"LY Jin","year":"2021","unstructured":"Jin LY et al (2021) Blood-spinal cord barrier in spinal cord injury: a review. J Neurotrauma 38(9):1203\u20131224","journal-title":"J Neurotrauma"},{"issue":"5","key":"5899_CR38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005603","volume":"12","author":"M Rengarajan","year":"2016","unstructured":"Rengarajan M, Hayer A, Theriot JA (2016) Endothelial cells use a formin-dependent phagocytosis-like process to internalize the bacterium Listeria monocytogenes. PLoS Pathog 12(5):e1005603","journal-title":"PLoS Pathog"},{"issue":"Pt 3","key":"5899_CR39","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1242\/jcs.108.3.967","volume":"108","author":"L Dini","year":"1995","unstructured":"Dini L et al (1995) Phagocytosis of apoptotic bodies by liver endothelial cells. J Cell Sci 108(Pt 3):967\u2013973","journal-title":"J Cell Sci"},{"issue":"5","key":"5899_CR40","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1002\/hep.1840060505","volume":"6","author":"AM Steffan","year":"1986","unstructured":"Steffan AM et al (1986) Phagocytosis, an unrecognized property of murine endothelial liver cells. Hepatology 6(5):830\u2013836","journal-title":"Hepatology"},{"issue":"3","key":"5899_CR41","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41593-018-0324-9","volume":"22","author":"T Zhou","year":"2019","unstructured":"Zhou T et al (2019) Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury. Nat Neurosci 22(3):421\u2013435","journal-title":"Nat Neurosci"},{"key":"5899_CR42","doi-asserted-by":"publisher","first-page":"631500","DOI":"10.3389\/fphys.2021.631500","volume":"12","author":"C Yao","year":"2021","unstructured":"Yao C, Cao X, Yu B (2021) Revascularization after traumatic spinal cord injury. Front Physiol 12:631500","journal-title":"Front Physiol"},{"issue":"6664","key":"5899_CR43","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1126\/science.adi6412","volume":"381","author":"JW Squair","year":"2023","unstructured":"Squair JW et al (2023) Recovery of walking after paralysis by regenerating characterized neurons to their natural target region. Science 381(6664):1338\u20131345","journal-title":"Science"},{"issue":"2","key":"5899_CR44","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1152\/physrev.00017.2017","volume":"98","author":"AP Tran","year":"2018","unstructured":"Tran AP, Warren PM, Silver J (2018) The biology of regeneration failure and success after spinal cord injury. Physiol Rev 98(2):881\u2013917","journal-title":"Physiol Rev"},{"issue":"6","key":"5899_CR45","first-page":"3361","volume":"16","author":"S Rahimpour","year":"2024","unstructured":"Rahimpour S, Clary BL, Nasoohi S, Berhanu YS, Brown CM (2024Dec 18) Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses. Aging and Disease. 16(6):3361","journal-title":"Aging and Disease."},{"issue":"8","key":"5899_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107571","volume":"300","author":"MB Fasken","year":"2024","unstructured":"Fasken MB et al (2024) A biallelic variant of the RNA exosome gene, EXOSC4, associated with neurodevelopmental defects impairs RNA exosome function and translation. J Biol Chem 300(8):107571","journal-title":"J Biol Chem"},{"key":"5899_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010496","author":"K Taniue","year":"2022","unstructured":"Taniue K et al (2022) RNA exosome component EXOSC4 amplified in multiple cancer types is required for the cancer cell survival. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23010496","journal-title":"Int J Mol Sci"},{"key":"5899_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118597","volume":"263","author":"YX Wang","year":"2020","unstructured":"Wang YX et al (2020) STX2 drives colorectal cancer proliferation via upregulation of EXOSC4. Life Sci 263:118597","journal-title":"Life Sci"},{"issue":"3","key":"5899_CR49","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s10142-024-01363-6","volume":"24","author":"N Wang","year":"2024","unstructured":"Wang N et al (2024) RUNX3 exerts tumor-suppressive role through inhibiting EXOSC4 expression. Funct Integr Genomics 24(3):103https:\/\/doi.org\/10.1007\/s10142-024-01363-6","journal-title":"Funct Integr Genomics"},{"key":"5899_CR50","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbae023","author":"Y Zang","year":"2024","unstructured":"Zang Y et al (2024) Genomic hallmarks and therapeutic targets of ribosome biogenesis in cancer. Brief Bioinform. https:\/\/doi.org\/10.1093\/bib\/bbae023","journal-title":"Brief Bioinform"},{"issue":"1","key":"5899_CR51","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1186\/s12967-025-06667-0","volume":"23","author":"C Yao","year":"2025","unstructured":"Yao C et al (2025) Identification EXOSC4 as a novel autoantigen of interstitial lung disease in rheumatoid arthritis. J Transl Med 23(1):765https:\/\/doi.org\/10.1186\/s12967-025-06667-0","journal-title":"J Transl Med"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-05899-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-026-05899-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-05899-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:03:19Z","timestamp":1779357799000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-026-05899-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5899"],"URL":"https:\/\/doi.org\/10.1007\/s12035-026-05899-5","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"30 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"642"}}