{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:41:11Z","timestamp":1791211271087,"version":"4.1.0"},"reference-count":98,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-026-05905-w","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:12:48Z","timestamp":1778724768000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Analysis of Mouse CSF Proteins in Experimental Autoimmune Encephalomyelitis Model and Cuprizone-Induced Demyelination Model by Olink Proteomics"],"prefix":"10.1007","volume":"63","author":[{"given":"Eline","family":"Bernaerts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Rutten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"De Visscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarne","family":"Beli\u00ebn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Berghmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Mitera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lien","family":"De Somer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Matthys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Vandooren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"issue":"12","key":"5905_CR1","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1080\/1744666X.2017.1400380","volume":"13","author":"J Lycke","year":"2017","unstructured":"Lycke J, Zetterberg H (2017) The role of blood and CSF biomarkers in the evaluation of new treatments against multiple sclerosis. Expert Rev Clin Immunol 13(12):1143\u20131153","journal-title":"Expert Rev Clin Immunol"},{"issue":"23","key":"5905_CR2","doi-asserted-by":"publisher","first-page":"12952","DOI":"10.1073\/pnas.1912839117","volume":"117","author":"J Huang","year":"2020","unstructured":"Huang J, Khademia M, Fugger L, Lindhe \u00d6, Novakova L, Axelsson M et al (2020) Inflammation-related plasma and CSF biomarkers for multiple sclerosis. Proceedings of the National Academy of Sciences - PNAS 117(23):12952\u201312960","journal-title":"Proceedings of the National Academy of Sciences - PNAS"},{"issue":"12","key":"5905_CR3","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/s41577-022-00718-z","volume":"22","author":"KE Attfield","year":"2022","unstructured":"Attfield KE, Jensen LT, Kaufmann M, Friese MA, Fugger L (2022) The immunology of multiple sclerosis. Nat Rev Immunol 22(12):734\u2013750","journal-title":"Nat Rev Immunol"},{"key":"5905_CR4","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.neuroscience.2024.12.029","volume":"567","author":"S Rida Zainab","year":"2025","unstructured":"Zainab RS, Khan ZJ, Tipu KM, Jahan F, Irshad N (2025) A review on multiple sclerosis: unravelling the complexities of pathogenesis, progression, mechanisms and therapeutic innovations. Neuroscience 567:133\u201349","journal-title":"Neuroscience"},{"issue":"4","key":"5905_CR5","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1111\/j.1476-5381.2011.01302.x","volume":"164","author":"CS Constantinescu","year":"2011","unstructured":"Constantinescu CS, Farooqi N, O\u2019Brien K, Gran B (2011) Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). Br J Pharmacol 164(4):1079\u2013106","journal-title":"Br J Pharmacol"},{"key":"5905_CR6","doi-asserted-by":"crossref","unstructured":"Terry RL, Ifergan I, Miller SD, Weissert R (2016) Experimental autoimmune encephalomyelitis in mice. Mult Scler 2016:145\u2013160","DOI":"10.1007\/7651_2014_88"},{"key":"5905_CR7","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.neubiorev.2014.10.004","volume":"47","author":"J Praet","year":"2014","unstructured":"Praet J, Guglielmetti C, Berneman Z, Van der Linden A, Ponsaerts P (2014) Cellular and molecular neuropathology of the cuprizone mouse model: clinical relevance for multiple sclerosis. Neurosci Biobehav Rev 47:485\u2013505","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"5905_CR8","doi-asserted-by":"publisher","first-page":"843","DOI":"10.3390\/cells9040843","volume":"9","author":"J Zhan","year":"2020","unstructured":"Zhan J, Mann T, Joost S, Behrangi N, Frank M, Kipp M (2020) The Cuprizone model: Dos and Do Nots. Cells 9(4):843","journal-title":"Cells"},{"key":"5905_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2021.100168","volume":"20","author":"L Wik","year":"2021","unstructured":"Wik L, Nordberg N, Broberg J, Bj\u00f6rkesten J, Assarsson E, Henriksson S et al (2021) Proximity Extension Assay in combination with Next-Generation Sequencing for high-throughput proteome-wide analysis. Mol Cell Proteomics 20:100168","journal-title":"Mol Cell Proteomics"},{"key":"5905_CR10","doi-asserted-by":"crossref","unstructured":"Landa J, Guasp M, Petit-Pedrol M, Mart\u00ednez-Hern\u00e1ndez E, Planagum\u00e0 J, Saiz A et al (2021) Seizure-related 6 homolog like 2 autoimmunity: Neurologic syndrome and antibody effects. Neurol Neuroimmunol\u00a0 Neuroinflamm 8(1):e916-e","DOI":"10.1212\/NXI.0000000000000916"},{"key":"5905_CR11","doi-asserted-by":"crossref","unstructured":"Rosenling T, Stoop MP, Attali A, Aken Hv, Suidgeest E, Christin C et al (2012) Profiling and identification of cerebrospinal fluid proteins in a rat EAE model of multiple sclerosis. J Proteome Res 11(4):2048\u201360","DOI":"10.1021\/pr201244t"},{"issue":"1","key":"5905_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1742-2094-7-1","volume":"7","author":"R Chui","year":"2010","unstructured":"Chui R, Dorovini-Zis K (2010) Regulation of CCL2 and CCL3 expression in human brain endothelial cells by cytokines and lipopolysaccharide. J Neuroinflammation 7(1):1","journal-title":"J Neuroinflammation"},{"issue":"5","key":"5905_CR13","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/sj.jcbfm.9600055","volume":"25","author":"SM Stamatovic","year":"2005","unstructured":"Stamatovic SM, Shakui P, Keep RF, Moore BB, Kunkel SL, Van Rooijen N et al (2005) Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability. J Cereb Blood Flow Metab 25(5):593\u2013606","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"5905_CR14","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1084\/jem.192.6.899","volume":"192","author":"BT Fife","year":"2000","unstructured":"Fife BT, Huffnagle GB, Kuziel WA, Karpus WJ (2000) Cc Chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis. J Exp Med 192(6):899\u2013905","journal-title":"J Exp Med"},{"issue":"6","key":"5905_CR15","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1084\/jem.193.6.713","volume":"193","author":"D Huang","year":"2001","unstructured":"Huang D, Wang J, Kivisakk P, Rollins BJ, Ransohoff RM (2001) Absence of Monocyte Chemoattractant Protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J Exp Med 193(6):713\u2013725","journal-title":"J Exp Med"},{"issue":"2","key":"5905_CR16","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.cell.2018.07.049","volume":"175","author":"G Di Liberto","year":"2018","unstructured":"Di Liberto G, Pantelyushin S, Kreutzfeldt M, Page N, Musardo S, Coras R et al (2018) Neurons under T cell attack coordinate phagocyte-mediated synaptic stripping. Cell 175(2):458\u201371.e19","journal-title":"Cell"},{"issue":"1","key":"5905_CR17","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/S0165-5728(98)00002-2","volume":"86","author":"C McManus","year":"1998","unstructured":"McManus C, Berman JW, Brett FM, Staunton H, Farrell M, Brosnan CF (1998) MCP-1, MCP-2 and MCP-3 expression in multiple sclerosis lesions: an immunohistochemical and in situ hybridization study. J Neuroimmunol 86(1):20\u201329","journal-title":"J Neuroimmunol"},{"issue":"1","key":"5905_CR18","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0022-510X(01)00680-3","volume":"195","author":"E Scarpini","year":"2002","unstructured":"Scarpini E, Galimberti D, Baron P, Clerici R, Ronzoni M, Conti G et al (2002) IP-10 and MCP-1 levels in CSF and serum from multiple sclerosis patients with different clinical subtypes of the disease. J Neurol Sci 195(1):41\u201346","journal-title":"J Neurol Sci"},{"issue":"1","key":"5905_CR19","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/S0165-5728(01)00261-2","volume":"115","author":"D Franciotta","year":"2001","unstructured":"Franciotta D, Martino G, Zardini E, Furlan R, Bergamaschi R, Andreoni L et al (2001) Serum and CSF levels of MCP-1 and IP-10 in multiple sclerosis patients with acute and stable disease and undergoing immunomodulatory therapies. J Neuroimmunol 115(1):192\u20138","journal-title":"J Neuroimmunol"},{"key":"5905_CR20","doi-asserted-by":"crossref","unstructured":"Mahad D, Callahan MK, Williams KA, Ubogu EE, Kivis\u00e4kk P, Tucky B et al (2006) Modulating CCR2 and CCL2 at the blood\u2013brain barrier: relevance for multiple sclerosis pathogenesis. Brain (London, England : 1878) 129(1):212\u201323","DOI":"10.1093\/brain\/awh655"},{"issue":"7","key":"5905_CR21","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/j.1468-1331.2004.00796.x","volume":"11","author":"TL S\u00f8rensen","year":"2004","unstructured":"S\u00f8rensen TL, Ransohoff RM, Strieter RM, Sellebjerg F (2004) Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis. Eur J Neurol 11(7):445\u2013449","journal-title":"Eur J Neurol"},{"issue":"1","key":"5905_CR22","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0165-5728(96)00203-2","volume":"74","author":"NG Gourmala","year":"1997","unstructured":"Gourmala NG, Buttini M, Limonta S, Sauter A, Boddeke HWGM (1997) Differential and time-dependent expression of monocyte chemoattractant protein-1 mRNA by astrocytes and macrophages in rat brain: effects of ischemia and peripheral lipopolysaccharide administration. J Neuroimmunol 74(1):35\u201344","journal-title":"J Neuroimmunol"},{"issue":"8","key":"5905_CR23","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1111\/j.1460-9568.1996.tb01316.x","volume":"8","author":"C-F Calvo","year":"1996","unstructured":"Calvo C-F, Yoshirnura T, Gelrnan M, Mallat M (1996) Production of monocyte chemotactic protein-1 by rat brain macrophages. Eur J Neurosci 8(8):1725\u20131734","journal-title":"Eur J Neurosci"},{"issue":"9","key":"5905_CR24","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1093\/neuonc\/noae077","volume":"26","author":"A Lastra Romero","year":"2024","unstructured":"Lastra Romero A, Seitz T, Zisiadis GA, Jeffery H, Osman AM (2024) EDA2R reflects the acute brain response to cranial irradiation in liquid biopsies. Neuro-oncology (Charlottesville, Va) 26(9):1617\u20131627","journal-title":"Neuro-oncology (Charlottesville, Va)"},{"key":"5905_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00904","volume":"9","author":"Y-W Ding","year":"2018","unstructured":"Ding Y-W, Pan S-Y, Xie W, Shen H-Y, Wang H-H (2018) Elevated soluble Fas and FasL in cerebrospinal fluid and serum of patients with anti-N-methyl-D-aspartate receptor encephalitis. Front Neurol 9:904","journal-title":"Front Neurol"},{"key":"5905_CR26","doi-asserted-by":"crossref","unstructured":"Hovelmeyer N, Hao Z, Kranidioti K, Kassiotis G, Buch T, Frommer F et al (2005) Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis. J Immunol (1950) 175(9):5875\u201384","DOI":"10.4049\/jimmunol.175.9.5875"},{"issue":"8","key":"5905_CR27","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1084\/jem.189.8.1195","volume":"189","author":"KA Sabelko-Downes","year":"1999","unstructured":"Sabelko-Downes KA, Cross AH, Russell JH (1999) Dual role for Fas Ligand in the initiation of and recovery from experimental allergic encephalomyelitis. J Exp Med 189(8):1195\u20131205","journal-title":"J Exp Med"},{"issue":"4","key":"5905_CR28","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1084\/jem.184.4.1513","volume":"184","author":"P Dowling","year":"1996","unstructured":"Dowling P, Shang G, Raval S, Menonna J, Cook S, Husar W (1996) Involvement of the CD95 (APO-1\/Fas) receptor\/ligand system in multiple sclerosis brain. J Exp Med 184(4):1513\u20131518","journal-title":"J Exp Med"},{"issue":"2","key":"5905_CR29","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.nbd.2009.10.016","volume":"37","author":"H Amke","year":"2010","unstructured":"Amke H, Michael W, Jasmin H, Wolfgang B, Gabriela S-R, Zhenyue H et al (2010) In toxic demyelination oligodendroglial cell death occurs early and is FAS independent In toxic demyelination oligodendroglial cell death occurs early and is FAS independent. Neurobiol Dis 37(2):362\u2013369","journal-title":"Neurobiol Dis"},{"issue":"4","key":"5905_CR30","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1177\/1352458507085137","volume":"14","author":"E Fainardi","year":"2008","unstructured":"Fainardi E, Rizzo R, Melchiorri L, Stignani M, Castellazzi M, Tamborino C et al (2008) CSF levels of soluble HLA-G and Fas molecules are inversely associated to MRI evidence of disease activity in patients with relapsing\u2014remitting multiple sclerosis. Mult Scler 14(4):446\u2013454","journal-title":"Mult Scler"},{"issue":"3","key":"5905_CR31","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1002\/eji.200425430","volume":"35","author":"PH Lalive","year":"2005","unstructured":"Lalive PH, Paglinawan R, Biollaz G, Kappos EA, Leone DP, Malipiero U et al (2005) TGF-\u03b2-treated microglia induce oligodendrocyte precursor cell chemotaxis through the HGF-c-Met pathway. Eur J Immunol 35(3):727\u2013737","journal-title":"Eur J Immunol"},{"issue":"2","key":"5905_CR32","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1034\/j.1600-0404.2002.01125.x","volume":"106","author":"Y Tsuboi","year":"2002","unstructured":"Tsuboi Y, Kakimoto K, Akatsu H, Daikuhara Y, Yamada T (2002) Hepatocyte growth factor in cerebrospinal fluid in neurologic disease: Hepatocyte growth factor in cerebrospinal fluid. Acta Neurol Scand 106(2):99\u2013103","journal-title":"Acta Neurol Scand"},{"issue":"1","key":"5905_CR33","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1186\/s12883-021-02356-9","volume":"21","author":"L-J Zhao","year":"2021","unstructured":"Zhao L-J, Wang Z-T, Ma Y-H, Zhang W, Dong Q, Yu J-T et al (2021) Associations of the cerebrospinal fluid hepatocyte growth factor with Alzheimer\u2019s disease pathology and cognitive function. BMC Neurol 21(1):387\u2013389","journal-title":"BMC Neurol"},{"key":"5905_CR34","doi-asserted-by":"crossref","unstructured":"Ebens A, Brose K, Leonardo ED, Jr MGH, Bladt F, Birchmeier C et al (1996) Hepatocyte growth factor\/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons. Neuron (Cambridge, Mass) 17(6):1157\u201372","DOI":"10.1016\/S0896-6273(00)80247-0"},{"issue":"1","key":"5905_CR35","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jneuroim.2012.06.008","volume":"251","author":"AM M\u00fcller","year":"2012","unstructured":"M\u00fcller AM, Jun E, Conlon H, Sadiq SA (2012) Cerebrospinal hepatocyte growth factor levels correlate negatively with disease activity in multiple sclerosis. J Neuroimmunol 251(1):80\u201386","journal-title":"J Neuroimmunol"},{"issue":"6","key":"5905_CR36","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/nn.3109","volume":"15","author":"L Bai","year":"2012","unstructured":"Bai L, Lennon DP, Caplan AI, DeChant A, Hecker J, Kranso J et al (2012) Hepatocyte growth factor mediates mesenchymal stem cell\u2013induced recovery in multiple sclerosis models. Nat Neurosci 15(6):862\u2013870","journal-title":"Nat Neurosci"},{"issue":"7","key":"5905_CR37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022623","volume":"6","author":"V Gudi","year":"2011","unstructured":"Gudi V, \u0160kuljec J, Yildiz \u00d6, Frichert K, Skripuletz T, Moharregh-Khiabani D et al (2011) Spatial and temporal profiles of growth factor expression during CNS demyelination reveal the dynamics of repair priming. PLoS ONE 6(7):e22623","journal-title":"PLoS ONE"},{"issue":"8","key":"5905_CR38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072399","volume":"8","author":"A Wullschleger","year":"2013","unstructured":"Wullschleger A, Kapina V, Molnarfi N, Courvoisier DS, Seebach JD, Santiago-Raber M-L et al (2013) Cerebrospinal fluid interleukin-6 in central nervous system inflammatory diseases. PLoS ONE 8(8):e72399","journal-title":"PLoS ONE"},{"issue":"1","key":"5905_CR39","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.immuni.2008.11.009","volume":"30","author":"H Ishigame","year":"2009","unstructured":"Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y et al (2009) Differential roles of Interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30(1):108\u201319","journal-title":"Immunity"},{"issue":"8","key":"5905_CR40","doi-asserted-by":"publisher","first-page":"2890","DOI":"10.1007\/s00415-021-10453-5","volume":"268","author":"A Ungureanu","year":"2021","unstructured":"Ungureanu A, Le Garff-Tavernier M, Costopoulos M, Parratte T, Brinet A, Durand H et al (2021) CSF Interleukin 6 is a useful marker to distinguish pseudotumoral CNS inflammatory diseases from primary CNS lymphoma. J Neurol 268(8):2890\u20132894","journal-title":"J Neurol"},{"key":"5905_CR41","doi-asserted-by":"crossref","unstructured":"Jovanovic DV, Di Battista JA, Martel-Pelletier J, Jolicoeur FoC, He Y, Zhang M et al (1998) IL-17 Stimulates the production and expression of proinflammatory cytokines, IL-\u03b2 and TNF-\u03b1, by human macrophages. J Immunol (1950) 160(7):3513\u201321","DOI":"10.4049\/jimmunol.160.7.3513"},{"issue":"2","key":"5905_CR42","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.immuni.2009.08.001","volume":"31","author":"CE Sutton","year":"2009","unstructured":"Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KHG (2009) Interleukin-1 and IL-23 induce innate IL-17 production from \u03b3\u03b4 T cells, amplifying Th17 responses and autoimmunity. Immunity 31(2):331\u2013341","journal-title":"Immunity"},{"issue":"11","key":"5905_CR43","doi-asserted-by":"publisher","first-page":"5468","DOI":"10.1210\/en.2010-0398","volume":"151","author":"T Hirata","year":"2010","unstructured":"Hirata T, Osuga Y, Takamura M, Kodama A, Hirota Y, Koga K et al (2010) Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1\u03b2-, TNF-\u03b1-, and IL-17A-stimulated endometriotic stromal cells. Endocrinology 151(11):5468\u20135476","journal-title":"Endocrinology"},{"issue":"2","key":"5905_CR44","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1177\/135245859900500206","volume":"5","author":"D Matusevicius","year":"1999","unstructured":"Matusevicius D, Kivis\u00e4kk P, He B, Kostulas N, \u00d6zenci V, Fredrikson S et al (1999) Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler 5(2):101\u2013104","journal-title":"Mult Scler"},{"issue":"10","key":"5905_CR45","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/nm1651","volume":"13","author":"H Kebir","year":"2007","unstructured":"Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M et al (2007) Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med 13(10):1173\u20131175","journal-title":"Nat Med"},{"issue":"7","key":"5905_CR46","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1007\/s00415-016-8128-x","volume":"263","author":"E Havrdov\u00e1","year":"2016","unstructured":"Havrdov\u00e1 E, Belova A, Goloborodko A, Tisserant A, Wright A, Wallstroem E et al (2016) Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study. J Neurol 263(7):1287\u201395","journal-title":"J Neurol"},{"issue":"1","key":"5905_CR47","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s12974-016-0757-6","volume":"13","author":"N Borjini","year":"2016","unstructured":"Borjini N, Fern\u00e1ndez M, Giardino L, Calz\u00e0 L (2016) Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis. J Neuroinflammation 13(1):291","journal-title":"J Neuroinflammation"},{"issue":"1","key":"5905_CR48","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1742-2094-2-7","volume":"2","author":"I Banisor","year":"2005","unstructured":"Banisor I, Leist TP, Kalman B (2005) Involvement of \u03b2-chemokines in the development of inflammatory demyelination. J Neuroinflammation 2(1):7","journal-title":"J Neuroinflammation"},{"key":"5905_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01079","volume":"8","author":"A Pittaluga","year":"2017","unstructured":"Pittaluga A (2017) CCL5\u2013Glutamate cross-talk in astrocyte-neuron communication in multiple sclerosis. Front Immunol 8:1079","journal-title":"Front Immunol"},{"issue":"4","key":"5905_CR50","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1189\/jlb.3A0815-359R","volume":"100","author":"D Ghosh","year":"2016","unstructured":"Ghosh D, Curtis AD, Wilkinson DS, Mannie MD (2016) Depletion of CD4+ CD25+ regulatory T cells confers susceptibility to experimental autoimmune encephalomyelitis (EAE) in GM\u2010CSF\u2010deficient Csf2\u2212\/\u2212 mice. J Leukoc Biol 100(4):747\u201360","journal-title":"J Leukoc Biol"},{"issue":"6","key":"5905_CR51","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/ni.2031","volume":"12","author":"M El-Behi","year":"2011","unstructured":"El-Behi M, Ciric B, Dai H, Yan Y, Cullimore M, Safavi F et al (2011) The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat Immunol 12(6):568\u2013575","journal-title":"Nat Immunol"},{"issue":"7","key":"5905_CR52","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1084\/jem.194.7.873","volume":"194","author":"JL McQualter","year":"2001","unstructured":"McQualter JL, Darwiche R, Ewing C, Onuki M, Kay TW, Hamilton JA et al (2001) Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis. J Exp Med 194(7):873\u2013881","journal-title":"J Exp Med"},{"issue":"3","key":"5905_CR53","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3109\/08923979809034820","volume":"20","author":"PB Carrieri","year":"1998","unstructured":"Carrieri PB, Provitera V, Rosa TD, Tartaglia G, Gorga F, Perrella O (1998) Profile of cerebrospinal fluid and serum cytokines in patients with Relapsing-Remitting Multiple Sclerosis. A correlation with clinical activity. Immunopharmacol Immunotoxicol 20(3):373\u2013382","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"5905_CR54","doi-asserted-by":"crossref","unstructured":"Ciric B, Rasouli J, Rostami A (2016) Chapter 5 - Granulocyte-macrophage colony-stimulating factor in central nervous system autoimmunity. Elsevier Inc, pp 71\u2013100","DOI":"10.1016\/B978-0-12-800763-1.00005-1"},{"issue":"4","key":"5905_CR55","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/j.1600-0404.1999.tb00394.x","volume":"100","author":"A Leonardi","year":"1999","unstructured":"Leonardi A, Penco S, Gramigni C, Bason C, Ribizzi G, Gazzola P et al (1999) Granulocyte-macrophage colony-stimulating factor activity in cerebrospinal fluid. Acta Neurol Scand 100(4):274\u2013277","journal-title":"Acta Neurol Scand"},{"issue":"1","key":"5905_CR56","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jneuroim.2005.01.020","volume":"162","author":"AC dos Santos","year":"2005","unstructured":"dos Santos AC, Barsante MM, Esteves Arantes RM, Bernard CCA, Teixeira MM, Carvalho-Tavares J (2005) CCL2 and CCL5 mediate leukocyte adhesion in experimental autoimmune encephalomyelitis\u2014an intravital microscopy study. J Neuroimmunol 162(1):122\u2013129","journal-title":"J Neuroimmunol"},{"key":"5905_CR57","doi-asserted-by":"crossref","unstructured":"Michael BD, Bricio-Moreno L, Sorensen EW, Miyabe Y, Lian J, Solomon T et al (2020) Astrocyte- and neuron-derived cxcl1 drives neutrophil transmigration and blood-brain barrier permeability in viral encephalitis. Cell Rep (Cambridge) 32(11):108150-","DOI":"10.1016\/j.celrep.2020.108150"},{"issue":"1","key":"5905_CR58","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1084\/jem.20141015","volume":"212","author":"JM Rumble","year":"2015","unstructured":"Rumble JM, Huber AK, Krishnamoorthy G, Srinivasan A, Giles DA, Zhang X et al (2015) Neutrophil-related factors as biomarkers in EAE and MS. J Exp Med 212(1):23\u201335","journal-title":"J Exp Med"},{"issue":"16","key":"5905_CR59","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1002\/glia.20587","volume":"55","author":"SL Carter","year":"2007","unstructured":"Carter SL, M\u00fcller M, Manders PM, Campbell IL (2007) Induction of the genes for Cxcl9 and Cxcl10 is dependent on IFN-\u03b3 but shows differential cellular expression in experimental autoimmune encephalomyelitis and by astrocytes and microglia in vitro. Glia 55(16):1728\u20131739","journal-title":"Glia"},{"key":"5905_CR60","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.jneuroim.2019.04.011","volume":"332","author":"AF Setiadi","year":"2019","unstructured":"Setiadi AF, Abbas AR, Jeet S, Wong K, Bischof A, Peng I et al (2019) IL-17A is associated with the breakdown of the blood-brain barrier in relapsing-remitting multiple sclerosis. J Neuroimmunol 332:147\u2013154","journal-title":"J Neuroimmunol"},{"issue":"8","key":"5905_CR61","doi-asserted-by":"publisher","first-page":"4437","DOI":"10.4049\/jimmunol.161.8.4437","volume":"161","author":"WS Begolka","year":"1998","unstructured":"Begolka WS, Vanderlugt CL, Rahbe SM, Miller SD (1998) Differential expression of inflammatory cytokines parallels progression of central nervous system pathology in two clinically distinct models of Multiple Sclerosis. The Journal of immunology (1950) 161(8):4437\u20134446","journal-title":"J Immunol (1950)"},{"issue":"3","key":"5905_CR62","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1172\/JCI115102","volume":"87","author":"K Selmaj","year":"1991","unstructured":"Selmaj K, Raine CS, Cannella B, Brosnan CF (1991) Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest 87(3):949\u2013954","journal-title":"J Clin Invest"},{"key":"5905_CR63","doi-asserted-by":"crossref","unstructured":"Rossi S, Studer V, Motta C, Germani G, Macchiarulo G, Buttari F et al (2014) Cerebrospinal fluid detection of interleukin-1\u03b2 in phase of remission predicts disease progression in multiple sclerosis. J Neuroinflamm 11(1):32-","DOI":"10.1186\/1742-2094-11-32"},{"issue":"2","key":"5905_CR64","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.immuni.2011.02.006","volume":"34","author":"G Guarda","year":"2011","unstructured":"Guarda G, Braun M, Staehli F, Tardivel A, Mattmann C, F\u00f6rster I et al (2011) Type I interferon inhibits Interleukin-1 production and inflammasome activation. Immunity 34(2):213\u2013223","journal-title":"Immunity"},{"issue":"11","key":"5905_CR65","doi-asserted-by":"publisher","first-page":"4355","DOI":"10.1073\/pnas.0812183106","volume":"106","author":"D Burger","year":"2009","unstructured":"Burger D, Molnarfi N, Weber MS, Brandt KJ, Benkhoucha M, Gruaz L et al (2009) Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1beta in human monocytes and multiple sclerosis. Proceedings of the National Academy of Sciences - PNAS 106(11):4355","journal-title":"Proceedings of the National Academy of Sciences - PNAS"},{"issue":"2","key":"5905_CR66","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1177\/1352458509355068","volume":"16","author":"J Mellerg\u00e5rd","year":"2010","unstructured":"Mellerg\u00e5rd J, Edstr\u00f6m M, Vrethem M, Ernerudh J, Dahle C (2010) Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid. Mult Scler 16(2):208\u2013217","journal-title":"Mult Scler"},{"issue":"3","key":"5905_CR67","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1002\/(SICI)1521-4141(199903)29:03<774::AID-IMMU774>3.0.CO;2-T","volume":"29","author":"G Kassiotis","year":"1999","unstructured":"Kassiotis G, Pasparakis M, Kollias G, Probert L (1999) TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein\u2010induced experimental autoimmune encephalomyelitis. Eur J Immunol 29(3):774\u2013780","journal-title":"Eur J Immunol"},{"issue":"6","key":"5905_CR68","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.4049\/jimmunol.138.6.1786","volume":"138","author":"P Scheurich","year":"1987","unstructured":"Scheurich P, Thoma B, Ucer U, Pfizenmaier K (1987) Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha- mediated enhancement of T cell responses. The Journal of immunology (1950) 138(6):1786\u20131790","journal-title":"The Journal of immunology (1950)"},{"issue":"7","key":"5905_CR69","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1056\/NEJM199108153250704","volume":"325","author":"MK Sharief","year":"1991","unstructured":"Sharief MK, Hentges R (1991) Association between tumor necrosis factor-\u03b1 and disease progression in patients with multiple sclerosis. N Engl J Med 325(7):467\u2013472","journal-title":"N Engl J Med"},{"issue":"2","key":"5905_CR70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090117","volume":"9","author":"SK Williams","year":"2014","unstructured":"Williams SK, Maier O, Fischer R, Fairless R, Hochmeister S, Stojic A et al (2014) Antibody-mediated inhibition of TNFR1 attenuates disease in a mouse model of multiple sclerosis. PLoS ONE 9(2):e90117","journal-title":"PLoS ONE"},{"issue":"1","key":"5905_CR71","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0165-5728(91)90073-G","volume":"32","author":"D Maimone","year":"1991","unstructured":"Maimone D, Gregory S, Arnason BGW, Reder AT (1991) Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis. J Neuroimmunol 32(1):67\u201374","journal-title":"J Neuroimmunol"},{"issue":"Pt A","key":"5905_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112849","volume":"142","author":"H Jingjing","year":"2024","unstructured":"Jingjing H, Tongqian W, Shirong Y, Lan M, Jing L, Shihui M et al (2024) S100A4 promotes experimental autoimmune encephalomyelitis by impacting microglial inflammation through TLR4\/NF-\u03baB signaling pathway. Int Immunopharmacol 142(Pt A):112849","journal-title":"Int Immunopharmacol"},{"key":"5905_CR73","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1525567","volume":"16","author":"T Wong","year":"2025","unstructured":"Wong T, Kang R, Yun K (2025) The multi-faceted immune modulatory role of S100A4 in cancer and chronic inflammatory disease. Front Immunol 16:1525567","journal-title":"Front Immunol"},{"key":"5905_CR74","doi-asserted-by":"crossref","unstructured":"Fissolo N, Matute-Blanch C, Osman M, Costa C, Pinteac R, Miro B et al (2021) CSF SERPINA3 levels are elevated in patients with progressive MS. Neurol Neuroimmunol Neuroinflamm 8(3):e983-e","DOI":"10.1212\/NXI.0000000000000983"},{"issue":"1","key":"5905_CR75","doi-asserted-by":"publisher","first-page":"5344","DOI":"10.1038\/s41467-025-60363-7","volume":"16","author":"L L\u00f6\u00dflein","year":"2025","unstructured":"L\u00f6\u00dflein L, Linnerbauer M, Zuber F, Tsaktanis T, Vandrey O, Peter A et al (2025) TGF\u03b1 controls checkpoints in CNS resident and infiltrating immune cells to promote resolution of inflammation. Nat Commun 16(1):5344\u20135417","journal-title":"Nat Commun"},{"key":"5905_CR76","doi-asserted-by":"crossref","unstructured":"Cirac A, Tsaktanis T, Beyer T, Linnerbauer M, Andlauer T, Grummel V et al (2021) The aryl hydrocarbon receptor\u2013dependent TGF-\u03b1\/VEGF-B ratio correlates with disease subtype and prognosis in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 8(5):e1043","DOI":"10.1212\/NXI.0000000000001043"},{"issue":"11","key":"5905_CR77","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s00011-019-01275-3","volume":"68","author":"T Flauzino","year":"2019","unstructured":"Flauzino T, Alfieri DF, de Carvalho Jennings Pereira WL, Oliveira SR, Kallaur AP, Lozovoy MAB et al (2019) The rs3761548 FOXP3 variant is associated with multiple sclerosis and transforming growth factor \u03b21 levels in female patients. Inflamm Res 68(11):933\u201343","journal-title":"Inflamm Res"},{"issue":"9-10","key":"5905_CR78","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1177\/0963689719852354","volume":"28","author":"J Xu","year":"2019","unstructured":"Xu J, Wang Y, Jiang H, Sun M, Gao J, Xie A (2019) TGF-\u03b2 in mice ameliorates experimental autoimmune encephalomyelitis in regulating NK cell activity. Cell Transplant 28(9\u201310):1155\u20131160","journal-title":"Cell Transplant"},{"issue":"7","key":"5905_CR79","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1002\/glia.23612","volume":"67","author":"R Baror","year":"2019","unstructured":"Baror R, Neumann B, Segel M, Chalut KJ, Fancy SPJ, Schafer DP et al (2019) Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors. Glia 67(7):1374\u20131384","journal-title":"Glia"},{"key":"5905_CR80","doi-asserted-by":"crossref","unstructured":"Hamaguchi M, Muramatsu R, Fujimura H, Mochizuki H, Kataoka H, Yamashita T (2019) Circulating transforming growth factor-\u03b21 facilitates remyelination in the adult central nervous system. eLife 8:e41869","DOI":"10.7554\/eLife.41869"},{"issue":"3","key":"5905_CR81","doi-asserted-by":"publisher","first-page":"510","DOI":"10.4103\/1673-5374.293147","volume":"16","author":"C Guevara","year":"2021","unstructured":"Guevara C, Ortiz F (2021) Glial-derived transforming growth factor \u03b21 (TGF-\u03b21): a key factor in multiple sclerosis neuroinflammation. Neural Regen Res 16(3):510\u2013511","journal-title":"Neural Regen Res"},{"issue":"23","key":"5905_CR82","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235934","volume":"20","author":"S Nataf","year":"2019","unstructured":"Nataf S, Guillen M, Pays L (2019) TGFB1-mediated gliosis in multiple sclerosis spinal cords is favored by the regionalized expression of HOXA5 and the age-dependent decline in androgen receptor ligands. Int J Mol Sci 20(23):5934","journal-title":"Int J Mol Sci"},{"key":"5905_CR83","doi-asserted-by":"publisher","first-page":"1088039","DOI":"10.3389\/fimmu.2023.1088039","volume":"14","author":"SJ Duesman","year":"2023","unstructured":"Duesman SJ, Ortega-Francisco S, Olguin-Alor R, Acevedo-Dominguez NA, Sestero CM, Chellappan R et al (2023) Transforming growth factor receptor III (Betaglycan) regulates the generation of pathogenic Th17 cells in EAE. Front Immunol 14:1088039","journal-title":"Front Immunol"},{"issue":"1","key":"5905_CR84","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-9","volume":"10","author":"D Stephan","year":"2013","unstructured":"Stephan D, Sbai O, Wen J, Couraud P-O, Putterman C, Khrestchatisky M et al (2013) TWEAK\/Fn14 pathway modulates properties of a human microvascular endothelial cell model of blood brain barrier. J Neuroinflammation 10(1):9","journal-title":"J Neuroinflammation"},{"issue":"1","key":"5905_CR85","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/S0165-5728(02)00368-5","volume":"133","author":"S Desplat-J\u00e9go","year":"2002","unstructured":"Desplat-J\u00e9go S, Varriale S, Creidy R, Terra R, Bernard D, Khrestchatisky M et al (2002) TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity. J Neuroimmunol 133(1):116\u2013123","journal-title":"J Neuroimmunol"},{"issue":"1","key":"5905_CR86","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.clim.2005.06.005","volume":"117","author":"S Desplat-J\u00e9go","year":"2005","unstructured":"Desplat-J\u00e9go S, Creidy R, Varriale S, Allaire N, Luo Y, Bernard D et al (2005) Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis. Clin Immunol 117(1):15\u201323","journal-title":"Clin Immunol"},{"issue":"12","key":"5905_CR87","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1097\/NEN.0b013e31818dab90","volume":"67","author":"B Serafini","year":"2008","unstructured":"Serafini B, Magliozzi R, Rosicarelli B, Reynolds R, Zheng TS, Aloisi F (2008) Expression of TWEAK and its receptor Fn14 in the multiple sclerosis brain: implications for inflammatory tissue injury. J Neuropathol Exp Neurol 67(12):1137\u20131148","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"5905_CR88","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12967-019-1789-3","volume":"17","author":"A Maarouf","year":"2019","unstructured":"Maarouf A, Stephan D, Ranjeva M-P, Ranjeva J-P, Pelletier J, Audoin B et al (2019) High levels of serum soluble TWEAK are associated with neuroinflammation during multiple sclerosis. J Transl Med 17(1):51\u201310","journal-title":"J Transl Med"},{"issue":"1","key":"5905_CR89","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1189\/jlb.0608347","volume":"85","author":"S Desplat-J\u00e9go","year":"2009","unstructured":"Desplat-J\u00e9go S, Feuillet L, Creidy R, Malikova I, Rance R, Khrestchatisky M et al (2009) TWEAK is expressed at the cell surface of monocytes during multiple sclerosis. J Leukoc Biol 85(1):132\u2013135","journal-title":"J Leukoc Biol"},{"key":"5905_CR90","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.590480","volume":"11","author":"A Glasnovic","year":"2020","unstructured":"Glasnovic A, O\u2019Mara N, Kovacic N, Grcevic D, Gajovic S (2020) RANK\/RANKL\/OPG signaling in the brain: a systematic review of the literature. Front Neurol 11:590480","journal-title":"Front Neurol"},{"key":"5905_CR91","first-page":"313","volume":"103","author":"K Mirzaei","year":"2012","unstructured":"Mirzaei K, Ahmadi S, Hossein-Nezhad A, Mokhtari F (2012) Potential role of OPG\/RANKL system and FokI genotypes in pathogenesis and clinical manifestations in multiple sclerosis. Minerva Med 103:313\u2013321","journal-title":"Minerva Med"},{"issue":"16","key":"5905_CR92","doi-asserted-by":"publisher","first-page":"12688","DOI":"10.3390\/ijms241612688","volume":"24","author":"T Abakumova","year":"2023","unstructured":"Abakumova T, Kuzkina A, Koshkin P, Pozdeeva D, Abakumov M, Melnikov P et al (2023) Localized increased permeability of blood-brain barrier for antibody conjugates in the cuprizone model of demyelination. Int J Mol Sci 24(16):12688","journal-title":"Int J Mol Sci"},{"issue":"4","key":"5905_CR93","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s12031-017-0888-y","volume":"61","author":"LS Tejedor","year":"2017","unstructured":"Tejedor LS, Wostradowski T, Gingele S, Skripuletz T, Gudi V, Stangel M (2017) The effect of stereotactic injections on demyelination and remyelination: a study in the Cuprizone model. J Mol Neurosci 61(4):479\u2013488","journal-title":"J Mol Neurosci"},{"issue":"6","key":"5905_CR94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234001","volume":"15","author":"J Shelestak","year":"2020","unstructured":"Shelestak J, Singhal N, Frankle L, Tomor R, Sternbach S, McDonough J et al (2020) Increased blood-brain barrier hyperpermeability coincides with mast cell activation early under cuprizone administration. PLoS ONE 15(6):e0234001","journal-title":"PLoS ONE"},{"issue":"2","key":"5905_CR95","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s12035-021-02660-y","volume":"59","author":"E Ong-P\u00e5lsson","year":"2022","unstructured":"Ong-P\u00e5lsson E, Njavro JR, Wilson Y, Pigoni M, Schmidt A, M\u00fcller SA et al (2022) The \u03b2-secretase substrate seizure 6\u2013like protein (SEZ6L) controls motor functions in mice. Mol Neurobiol 59(2):1183\u20131198","journal-title":"Mol Neurobiol"},{"issue":"19","key":"5905_CR96","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911342","volume":"23","author":"C Lubrich","year":"2022","unstructured":"Lubrich C, Giesler P, Kipp M (2022) Motor behavioral deficits in the Cuprizone model: validity of the Rotarod test paradigm. Int J Mol Sci 23(19):11342","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5905_CR97","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s42466-022-00218-4","volume":"4","author":"A Kather","year":"2022","unstructured":"Kather A, Holtbernd F, Brunkhorst R, Hasan D, Markewitz R, Wandinger K-P et al (2022) Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature. Neurol Res Pract 4(1):54\u20137","journal-title":"Neurol Res Pract"},{"issue":"19","key":"5905_CR98","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911532","volume":"23","author":"D Birmpili","year":"2022","unstructured":"Birmpili D, Charmarke Askar I, Bigaut K, Bagnard D (2022) The translatability of Multiple Sclerosis animal models for biomarkers discovery and their clinical use. Int J Mol Sci 23(19):11532","journal-title":"Int J Mol Sci"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-05905-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-026-05905-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-05905-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:15:00Z","timestamp":1778735700000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-026-05905-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":98,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5905"],"URL":"https:\/\/doi.org\/10.1007\/s12035-026-05905-w","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"17 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"629"}}