{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:12:22Z","timestamp":1780485142825,"version":"3.54.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-026-05987-6","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:56:20Z","timestamp":1780484180000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Soluble TREM1 Contributes to Aging-Related Neurodegeneration via ROBO2\/ERK Pathway"],"prefix":"10.1007","volume":"63","author":[{"given":"Jing-Wen","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Cheng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8095-4856","authenticated-orcid":false,"given":"Yi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4170-1156","authenticated-orcid":false,"given":"Teng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"issue":"10423","key":"5987_CR1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0140-6736(23)01419-8","volume":"403","author":"Y Ben-Shlomo","year":"2024","unstructured":"Ben-Shlomo Y, Darweesh S, Llibre-Guerra J, Marras C, San Luciano M, Tanner C (2024) The epidemiology of Parkinson\u2019s disease. Lancet 403(10423):283\u2013292. https:\/\/doi.org\/10.1016\/S0140-6736(23)01419-8","journal-title":"Lancet"},{"issue":"10284","key":"5987_CR2","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","volume":"397","author":"P Scheltens","year":"2021","unstructured":"Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chetelat G, Teunissen CE et al (2021) Alzheimer\u2019s disease. Lancet 397(10284):1577\u20131590. https:\/\/doi.org\/10.1016\/S0140-6736(20)32205-4","journal-title":"Lancet"},{"key":"5987_CR3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/978-981-13-3681-2_4","volume":"91","author":"L Walker","year":"2019","unstructured":"Walker L, McAleese KE, Erskine D, Attems J (2019) Neurodegenerative diseases and ageing. Subcell Biochem 91:75\u2013106. https:\/\/doi.org\/10.1007\/978-981-13-3681-2_4","journal-title":"Subcell Biochem"},{"key":"5987_CR4","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1146\/annurev.pathmechdis.2.010506.092044","volume":"3","author":"BA Yankner","year":"2008","unstructured":"Yankner BA, Lu T, Loerch P (2008) The aging brain. Annu Rev Pathol Mech Dis 3:41\u201366. https:\/\/doi.org\/10.1146\/annurev.pathmechdis.2.010506.092044","journal-title":"Annu Rev Pathol Mech Dis"},{"issue":"5","key":"5987_CR5","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/s41577-024-01104-7","volume":"25","author":"MT Heneka","year":"2025","unstructured":"Heneka MT, van der Flier WM, Jessen F, Hoozemanns J, Thal DR, Boche D et al (2025) Neuroinflammation in Alzheimer disease. Nat Rev Immunol 25(5):321\u2013352. https:\/\/doi.org\/10.1038\/s41577-024-01104-7","journal-title":"Nat Rev Immunol"},{"key":"5987_CR6","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4784268","volume":"2018","author":"G Gelders","year":"2018","unstructured":"Gelders G, Baekelandt V, Van der Perren A (2018) Linking neuroinflammation and neurodegeneration in Parkinson\u2019s disease. J Immunol Res 2018:4784268. https:\/\/doi.org\/10.1155\/2018\/4784268","journal-title":"J Immunol Res"},{"issue":"6","key":"5987_CR7","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.neurobiolaging.2013.11.026","volume":"35","author":"T Jiang","year":"2014","unstructured":"Jiang T, Yu JT, Zhu XC, Tan MS, Gu LZ, Zhang YD et al (2014) Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice. Neurobiol Aging 35(6):1243\u20131251. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2013.11.026","journal-title":"Neurobiol Aging"},{"issue":"3","key":"5987_CR8","doi-asserted-by":"publisher","first-page":"633","DOI":"10.3233\/JAD-131148","volume":"38","author":"MS Tan","year":"2014","unstructured":"Tan MS, Yu JT, Jiang T, Zhu XC, Guan HS, Tan L (2014) IL12\/23 p40 inhibition ameliorates Alzheimer\u2019s disease-associated neuropathology and spatial memory in SAMP8 mice. J Alzheimers Dis 38(3):633\u2013646. https:\/\/doi.org\/10.3233\/JAD-131148","journal-title":"J Alzheimers Dis"},{"issue":"5","key":"5987_CR9","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1038\/s41593-024-01610-w","volume":"27","author":"EN Wilson","year":"2024","unstructured":"Wilson EN, Wang C, Swarovski MS, Zera KA, Ennerfelt HE, Wang Q et al (2024) TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models. Nat Neurosci 27(5):873\u2013885. https:\/\/doi.org\/10.1038\/s41593-024-01610-w","journal-title":"Nat Neurosci"},{"issue":"5","key":"5987_CR10","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00401-016-1622-5","volume":"132","author":"T Jiang","year":"2016","unstructured":"Jiang T, Zhang YD, Gao Q, Zhou JS, Zhu XC, Lu H et al (2016) TREM1 facilitates microglial phagocytosis of amyloid beta. Acta Neuropathol 132(5):667\u2013683. https:\/\/doi.org\/10.1007\/s00401-016-1622-5","journal-title":"Acta Neuropathol"},{"issue":"11","key":"5987_CR11","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1161\/CIRCRESAHA.116.305628","volume":"116","author":"A Boufenzer","year":"2015","unstructured":"Boufenzer A, Lemarie J, Simon T, Derive M, Bouazza Y, Tran N et al (2015) TREM-1 mediates inflammatory injury and cardiac remodeling following myocardial infarction. Circ Res 116(11):1772\u20131782. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.305628","journal-title":"Circ Res"},{"issue":"11","key":"5987_CR12","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1084\/jem.20040708","volume":"200","author":"S Gibot","year":"2004","unstructured":"Gibot S, Kolopp-Sarda MN, Bene MC, Bollaert PE, Lozniewski A, Mory F et al (2004) A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J Exp Med 200(11):1419\u20131426. https:\/\/doi.org\/10.1084\/jem.20040708","journal-title":"J Exp Med"},{"issue":"12","key":"5987_CR13","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1038\/ni1411","volume":"7","author":"J Klesney-Tait","year":"2006","unstructured":"Klesney-Tait J, Turnbull IR, Colonna M (2006) The TREM receptor family and signal integration. Nat Immunol 7(12):1266\u20131273. https:\/\/doi.org\/10.1038\/ni1411","journal-title":"Nat Immunol"},{"issue":"9","key":"5987_CR14","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/s41577-023-00837-1","volume":"23","author":"M Colonna","year":"2023","unstructured":"Colonna M (2023) The biology of TREM receptors. Nat Rev Immunol 23(9):580\u2013594. https:\/\/doi.org\/10.1038\/s41577-023-00837-1","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"5987_CR15","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s00011-018-1149-4","volume":"67","author":"I Bellos","year":"2018","unstructured":"Bellos I, Fitrou G, Daskalakis G, Thomakos N, Papantoniou N, Pergialiotis V (2018) Soluble TREM-1 as a predictive factor of neonatal sepsis: a meta-analysis. Inflamm Res 67(7):571\u2013578. https:\/\/doi.org\/10.1007\/s00011-018-1149-4","journal-title":"Inflamm Res"},{"issue":"1","key":"5987_CR16","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1080\/1354750X.2016.1204005","volume":"22","author":"T Brenner","year":"2017","unstructured":"Brenner T, Uhle F, Fleming T, Wieland M, Schmoch T, Schmitt F et al (2017) Soluble TREM-1 as a diagnostic and prognostic biomarker in patients with septic shock: an observational clinical study. Biomarkers 22(1):63\u201369. https:\/\/doi.org\/10.1080\/1354750X.2016.1204005","journal-title":"Biomarkers"},{"issue":"1","key":"5987_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07758-9","volume":"22","author":"Z Wang","year":"2022","unstructured":"Wang Z, Chang B, Zhang Y, Chen J, Xie F, Xiang Y et al (2022) Clinical value of serum sTREM-1 and HBP levels in combination with traditional inflammatory markers in diagnosing hospital-acquired pneumonia in elderly. BMC Infect Dis 22(1):773. https:\/\/doi.org\/10.1186\/s12879-022-07758-9","journal-title":"BMC Infect Dis"},{"issue":"1","key":"5987_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-05196-z","volume":"20","author":"X Zhao","year":"2020","unstructured":"Zhao X, Xu L, Yang Z, Sun B, Wang Y, Li G et al (2020) Significance of sTREM-1 in early prediction of ventilator-associated pneumonia in neonates: a single-center, prospective, observational study. BMC Infect Dis 20(1):542. https:\/\/doi.org\/10.1186\/s12879-020-05196-z","journal-title":"BMC Infect Dis"},{"issue":"5","key":"5987_CR19","doi-asserted-by":"publisher","first-page":"101","DOI":"10.21315\/mjms2017.24.5.11","volume":"24","author":"WN Arifin","year":"2017","unstructured":"Arifin WN, Zahiruddin WM (2017) Sample size calculation in animal studies using resource equation approach. Malays J Med Sci 24(5):101\u2013105. https:\/\/doi.org\/10.21315\/mjms2017.24.5.11","journal-title":"Malays J Med Sci"},{"issue":"12","key":"5987_CR20","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1007\/s40520-019-01122-9","volume":"31","author":"T Jiang","year":"2019","unstructured":"Jiang T, Gong PY, Tan MS, Xue X, Huang S, Zhou JS et al (2019) Soluble TREM1 concentrations are increased and positively correlated with total tau levels in the plasma of patients with Alzheimer\u2019s disease. Aging Clin Exp Res 31(12):1801\u20131805. https:\/\/doi.org\/10.1007\/s40520-019-01122-9","journal-title":"Aging Clin Exp Res"},{"issue":"1","key":"5987_CR21","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s12974-022-02582-z","volume":"19","author":"X Shi","year":"2022","unstructured":"Shi X, Wei T, Hu Y, Wang M, Tang Y (2022) The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study. J Neuroinflammation 19(1):218. https:\/\/doi.org\/10.1186\/s12974-022-02582-z","journal-title":"J Neuroinflammation"},{"issue":"1","key":"5987_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02796-9","volume":"20","author":"AHYS Hok","year":"2023","unstructured":"Hok AHYS, Del Campo M, Boiten WA, Stoops E, Vanhooren M, Lemstra AW et al (2023) Neuroinflammatory CSF biomarkers MIF, sTREM1, and sTREM2 show dynamic expression profiles in Alzheimer\u2019s disease. J Neuroinflammation 20(1):107. https:\/\/doi.org\/10.1186\/s12974-023-02796-9","journal-title":"J Neuroinflammation"},{"key":"5987_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1481526","volume":"16","author":"H Shu","year":"2024","unstructured":"Shu H, Ding G, Xu X, Huang X, He R (2024) Association of CSF soluble TREM1 levels with hippocampal atrophy in cognitively impaired older adults. Front Aging Neurosci 16:1481526. https:\/\/doi.org\/10.3389\/fnagi.2024.1481526","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"5987_CR24","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0197-4580(99)00006-8","volume":"20","author":"Y Nomura","year":"1999","unstructured":"Nomura Y, Okuma Y (1999) Age-related defects in lifespan and learning ability in SAMP8 mice. Neurobiol Aging 20(2):111\u2013115","journal-title":"Neurobiol Aging"},{"key":"5987_CR25","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S489474","volume":"17","author":"XX Fu","year":"2024","unstructured":"Fu XX, Huang ZH, Wang SY, Qi JW, Luo ZJ, E Y et al (2024) Knockdown of TREML2 alleviates neuropathological hallmarks and cognitive deficiency in a model of sporadic Alzheimer\u2019s disease. J Inflamm Res 17:10471\u201310478. https:\/\/doi.org\/10.2147\/JIR.S489474","journal-title":"J Inflamm Res"},{"issue":"3","key":"5987_CR26","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1177\/13872877251320418","volume":"104","author":"SY Wang","year":"2025","unstructured":"Wang SY, Huang ZH, Duan R, Fu XX, Qi JW, Luo ZJ et al (2025) IL-34\/TREM2 modulates microglia-mediated inflammation and provides neuroprotection in a mouse model of sporadic Alzheimer\u2019s disease. J Alzheimers Dis 104(3):875\u2013885. https:\/\/doi.org\/10.1177\/13872877251320418","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"5987_CR27","doi-asserted-by":"publisher","first-page":"919","DOI":"10.3233\/JAD-230133","volume":"94","author":"XX Fu","year":"2023","unstructured":"Fu XX, Wei B, Cao HM, Duan R, Deng Y, Lian HW et al (2023) Telmisartan alleviates Alzheimer\u2019s disease-related neuropathologies and cognitive impairments. J Alzheimers Dis 94(3):919\u2013933. https:\/\/doi.org\/10.3233\/JAD-230133","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"5987_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-10973-8","volume":"12","author":"L Lu","year":"2022","unstructured":"Lu L, Liu X, Fu J, Liang J, Hou Y, Dou H (2022) sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K-AKT signaling pathway. Sci Rep 12(1):7047. https:\/\/doi.org\/10.1038\/s41598-022-10973-8","journal-title":"Sci Rep"},{"key":"5987_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104274","volume":"85","author":"Q Zhou","year":"2022","unstructured":"Zhou Q, Meng D, Li F, Zhang X, Liu L, Zhu Y et al (2022) Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling. EBioMedicine 85:104274. https:\/\/doi.org\/10.1016\/j.ebiom.2022.104274","journal-title":"EBioMedicine"},{"key":"5987_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/srep15535","volume":"5","author":"H Ge","year":"2015","unstructured":"Ge H, Tan L, Wu P, Yin Y, Liu X, Meng H et al (2015) Poly-L-ornithine promotes preferred differentiation of neural stem\/progenitor cells via ERK signalling pathway. Sci Rep 5:15535. https:\/\/doi.org\/10.1038\/srep15535","journal-title":"Sci Rep"},{"issue":"12","key":"5987_CR31","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.1016\/j.neurobiolaging.2015.08.019","volume":"36","author":"T Jiang","year":"2015","unstructured":"Jiang T, Tan L, Zhu XC, Zhou JS, Cao L, Tan MS et al (2015) Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice. Neurobiol Aging 36(12):3176\u20133186. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.08.019","journal-title":"Neurobiol Aging"},{"issue":"2","key":"5987_CR32","doi-asserted-by":"publisher","first-page":"434","DOI":"10.4103\/1673-5374.346468","volume":"18","author":"SY Wang","year":"2023","unstructured":"Wang SY, Fu XX, Duan R, Wei B, Cao HM, Yan E et al (2023) The Alzheimer\u2019s disease-associated gene TREML2 modulates inflammation by regulating microglia polarization and NLRP3 inflammasome activation. Neural Regen Res 18(2):434\u2013438. https:\/\/doi.org\/10.4103\/1673-5374.346468","journal-title":"Neural Regen Res"},{"issue":"24","key":"5987_CR33","doi-asserted-by":"publisher","first-page":"11113","DOI":"10.1111\/jcmm.17033","volume":"25","author":"T Liu","year":"2021","unstructured":"Liu T, Chen S, Xie X, Liu H, Wang Y, Qi S et al (2021) Soluble TREM-1, as a new ligand for the membrane receptor Robo2, promotes hepatic stellate cells activation and liver fibrosis. J Cell Mol Med 25(24):11113\u201311127. https:\/\/doi.org\/10.1111\/jcmm.17033","journal-title":"J Cell Mol Med"},{"key":"5987_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.807898","volume":"8","author":"Y Li","year":"2021","unstructured":"Li Y, Yu M, Tan L, Xue S, Du X, Wu X et al (2021) Robo2 and Gen1 coregulate ureteric budding by activating the MAPK\/ERK signaling pathway in mice. Front Med (Lausanne) 8:807898. https:\/\/doi.org\/10.3389\/fmed.2021.807898","journal-title":"Front Med (Lausanne)"},{"key":"5987_CR35","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.bbrc.2023.02.050","volume":"653","author":"X Du","year":"2023","unstructured":"Du X, Yu M, Ju H, Xue S, Li Y, Wu X et al (2023) Inhibition of MAPK\/ERK pathway activation rescues congenital anomalies of the kidney and urinary tract (CAKUT) in Robo2(PB\/+) Gen1(PB\/+) mice. Biochem Biophys Res Commun 653:153\u2013160. https:\/\/doi.org\/10.1016\/j.bbrc.2023.02.050","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"5987_CR36","doi-asserted-by":"publisher","first-page":"6309","DOI":"10.1007\/s12035-015-9535-1","volume":"53","author":"LM Mao","year":"2016","unstructured":"Mao LM, Wang JQ (2016) Synaptically localized mitogen-activated protein kinases: local substrates and regulation. Mol Neurobiol 53(9):6309\u20136315. https:\/\/doi.org\/10.1007\/s12035-015-9535-1","journal-title":"Mol Neurobiol"},{"issue":"2","key":"5987_CR37","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1007\/s12035-014-8811-9","volume":"51","author":"J Ma","year":"2015","unstructured":"Ma J, Jiang T, Tan L, Yu JT (2015) TYROBP in Alzheimer\u2019s disease. Mol Neurobiol 51(2):820\u2013826. https:\/\/doi.org\/10.1007\/s12035-014-8811-9","journal-title":"Mol Neurobiol"},{"key":"5987_CR38","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.neurobiolaging.2019.05.007","volume":"81","author":"HC Achterberg","year":"2019","unstructured":"Achterberg HC, Sorensen L, Wolters FJ, Niessen WJ, Vernooij MW, Ikram MA et al (2019) The value of hippocampal volume, shape, and texture for 11-year prediction of dementia: a population-based study. Neurobiol Aging 81:58\u201366. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2019.05.007","journal-title":"Neurobiol Aging"},{"issue":"1\u20132","key":"5987_CR39","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/s0928-4257(01)00084-5","volume":"96","author":"KT Nguyen-Ba-Charvet","year":"2002","unstructured":"Nguyen-Ba-Charvet KT, Chedotal A (2002) Role of slit proteins in the vertebrate brain. J Physiol Paris 96(1\u20132):91\u201398. https:\/\/doi.org\/10.1016\/s0928-4257(01)00084-5","journal-title":"J Physiol Paris"},{"issue":"3","key":"5987_CR40","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1242\/dev.076588","volume":"139","author":"YA Pan","year":"2012","unstructured":"Pan YA, Choy M, Prober DA, Schier AF (2012) Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons. Development 139(3):591\u2013600. https:\/\/doi.org\/10.1242\/dev.076588","journal-title":"Development"},{"issue":"1","key":"5987_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-020-05100-7","volume":"13","author":"T Sasaki","year":"2020","unstructured":"Sasaki T, Komatsu Y, Yamamori T (2020) Expression patterns of SLIT\/ROBO mRNAs reveal a characteristic feature in the entorhinal-hippocampal area of macaque monkeys. BMC Res Notes 13(1):262. https:\/\/doi.org\/10.1186\/s13104-020-05100-7","journal-title":"BMC Res Notes"},{"issue":"3","key":"5987_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109828","volume":"37","author":"H Blockus","year":"2021","unstructured":"Blockus H, Rolotti SV, Szoboszlay M, Peze-Heidsieck E, Ming T, Schroeder A et al (2021) Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function. Cell Rep 37(3):109828. https:\/\/doi.org\/10.1016\/j.celrep.2021.109828","journal-title":"Cell Rep"},{"issue":"4","key":"5987_CR43","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/S0896-6273(02)00830-9","volume":"35","author":"N Burgess","year":"2002","unstructured":"Burgess N, Maguire EA, O\u2019Keefe J (2002) The human hippocampus and spatial and episodic memory. Neuron 35(4):625\u2013641","journal-title":"Neuron"},{"issue":"1","key":"5987_CR44","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.neuron.2004.09.010","volume":"44","author":"DM Walsh","year":"2004","unstructured":"Walsh DM, Selkoe DJ (2004) Deciphering the molecular basis of memory failure in Alzheimer\u2019s disease. Neuron 44(1):181\u2013193. https:\/\/doi.org\/10.1016\/j.neuron.2004.09.010","journal-title":"Neuron"},{"issue":"11","key":"5987_CR45","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202215984","volume":"15","author":"M Indrigo","year":"2023","unstructured":"Indrigo M, Morella I, Orellana D, d\u2019Isa R, Papale A, Parra R et al (2023) Nuclear ERK1\/2 signaling potentiation enhances neuroprotection and cognition via Importin\u03b11\/KPNA2. EMBO Mol Med 15(11):e15984. https:\/\/doi.org\/10.15252\/emmm.202215984","journal-title":"EMBO Mol Med"},{"issue":"3","key":"5987_CR46","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.neuroscience.2008.05.056","volume":"155","author":"N Shioda","year":"2008","unstructured":"Shioda N, Han F, Morioka M, Fukunaga K (2008) Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) enhances neurogenesis via phosphatidylinositol 3-kinase\/Akt and extracellular signal regulated kinase activation in the hippocampal subgranular zone after mouse focal cerebral ischemia. Neuroscience 155(3):876\u2013887. https:\/\/doi.org\/10.1016\/j.neuroscience.2008.05.056","journal-title":"Neuroscience"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-05987-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-026-05987-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-05987-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:56:21Z","timestamp":1780484181000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-026-05987-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5987"],"URL":"https:\/\/doi.org\/10.1007\/s12035-026-05987-6","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"29 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal experiments in this study were approved by the Ethics Committee of Nanjing First Hospital (approval No. DWSY-25012644). All procedures involving animal experiments were performed according to the guidelines of ARRIVE.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"671"}}