{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:15:51Z","timestamp":1793229351406,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-026-05998-3","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:49:25Z","timestamp":1781527765000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Circ_0092222 is Enhanced in Alzheimer\u2019s Disease and Exacerbates A\u03b2-induced Neurotoxicity Through Sponging miR-331-3p"],"prefix":"10.1007","volume":"63","author":[{"given":"Yan","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niannian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"issue":"3","key":"5998_CR1","doi-asserted-by":"publisher","first-page":"313","DOI":"10.14283\/jpad.2021.15","volume":"8","author":"XX Zhang","year":"2021","unstructured":"Zhang XX, Tian Y, Wang ZT, Ma YH, Tan L, Yu JT (2021) The epidemiology of Alzheimer\u2019s disease modifiable risk factors and prevention. J Prev Alzheimers Dis 8(3):313\u201321","journal-title":"J Prev Alzheimers Dis"},{"key":"5998_CR2","first-page":"69181","volume":"69181","author":"AA Testo","year":"2025","unstructured":"Testo AA, Roundy GDJA, Dumas JA (2025) Cognitive decline in Alzheimer\u2019s disease. Curr Top Behav Neurosci 69181:69181\u201369195","journal-title":"Curr Top Behav Neurosci"},{"issue":"1","key":"5998_CR3","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/s41392-023-01484-7","volume":"8","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Chen H, Li R, Sterling K, Song W (2023) Amyloid beta-based therapy for Alzheimer's disease: challenges, successes and future. Signal Transduct Target Ther 8(1):248.","journal-title":"Signal Transduct Target Ther"},{"key":"5998_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076518","author":"BHM Twarowski","year":"2023","unstructured":"Twarowski BHM, Herbet M (2023) Inflammatory processes in Alzheimer\u2019s disease-pathomechanism, diagnosis and treatment: a review. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms24076518","journal-title":"Int J Mol Sci"},{"issue":"3","key":"5998_CR5","doi-asserted-by":"publisher","first-page":"e70300","DOI":"10.1111\/cns.70300","volume":"31","author":"Y Wu","year":"2025","unstructured":"Wu Y, Liu X, Luo G, Li Q, Guo B, Li L et al (2025) DNLA Delayed the appearance of learning and memory impairment of APP\/PS1 mice: involvement of mTOR\/TFEB\/v-ATPase signaling pathway. CNS Neurosci Ther 31(3):e70300","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"5998_CR6","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.mcna.2024.10.003","volume":"109","author":"CM Hales","year":"2025","unstructured":"Hales CM (2025) Alzheimer\u2019s disease diagnosis and management in the age of amyloid monoclonal antibodies. Med Clin North Am 109(2):463\u2013483","journal-title":"Med Clin North Am"},{"issue":"4","key":"5998_CR7","doi-asserted-by":"publisher","first-page":"e12514","DOI":"10.1002\/dad2.12514","volume":"15","author":"Z Xiao","year":"2023","unstructured":"Xiao Z, Wu W, Ma X, Wu J, Liang X, Zhou X et al (2023) Plasma p-tau217, p-tau181, and NfL as early indicators of dementia risk in a community cohort: the Shanghai aging study. Alzheimers Dement (Amst) 15(4):e12514","journal-title":"Alzheimers Dement (Amst)"},{"issue":"1","key":"5998_CR8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/10409238.2023.2185764","volume":"58","author":"J Dong","year":"2023","unstructured":"Dong J, Zeng Z, Huang Y, Chen C, Cheng ZZQ, Zhu Q (2023) Challenges and opportunities for circRNA identification and delivery. Crit Rev Biochem Mol Biol 58(1):19\u201335","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"9","key":"5998_CR9","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41568-024-00721-7","volume":"24","author":"VM Conn","year":"2024","unstructured":"Conn VM, Chinnaiyan AMCSJ, Conn SJ (2024) Circular RNA in cancer. Nat Rev Cancer 24(9):597\u2013613","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"5998_CR10","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s11010-021-04286-z","volume":"477","author":"J Ju","year":"2022","unstructured":"Ju J, Song YN, Chen XZ, Wang T, Liu CYWK, Wang K (2022) CircRNA is a potential target for cardiovascular diseases treatment. Mol Cell Biochem 477(2):417\u2013430","journal-title":"Mol Cell Biochem"},{"key":"5998_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.745066","volume":"14","author":"M Chen","year":"2021","unstructured":"Chen M, Lai X, Wang X, Ying J, Zhang L, Zhou B et al (2021) Long non-coding RNAs and circular RNAs: insights into microglia and astrocyte mediated neurological diseases. Front Mol Neurosci 14:745066","journal-title":"Front Mol Neurosci"},{"key":"5998_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1464015","volume":"17","author":"HZ Alshareef","year":"2025","unstructured":"Alshareef HZ, Ballinger T, Rojas EVDLAM, van der Linden AM (2025) Loss of age-accumulated crh-1 circRNAs ameliorate amyloid \u03b2-induced toxicity in a C. elegans model for Alzheimer\u2019s disease. Front Aging Neurosci 17:1464015","journal-title":"Front Aging Neurosci"},{"issue":"23","key":"5998_CR13","doi-asserted-by":"publisher","first-page":"e39830","DOI":"10.1016\/j.heliyon.2024.e39830","volume":"10","author":"J Feng","year":"2024","unstructured":"Feng J, Zhao J, Kuang Y, Zhou Y, Ye Z, He Y et al (2024) Hsa_Circ_0105596\/FTO inhibits progression of Parkinson\u2019s disease by sponging miR-187-3p and regulating eEF2. Heliyon 10(23):e39830","journal-title":"Heliyon"},{"issue":"3","key":"5998_CR14","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3390\/biom16030356","volume":"16","author":"H Celik","year":"2026","unstructured":"Celik H, Celik O, Aydin S, Kucukler S, Comakli S, Akay R et al (2026) Evaluation of plasma-derived hsa_circ_003077 for non-invasive diagnosis of Alzheimer\u2019s disease. Biomolecules. 16(3):356","journal-title":"Biomolecules."},{"issue":"1","key":"5998_CR15","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s40364-022-00405-0","volume":"10","author":"Z Ren","year":"2022","unstructured":"Ren Z, Chu C, Pang Y, Cai HJLA, Jia LA (2022) A circular RNA blood panel that differentiates Alzheimer\u2019s disease from other dementia types. Biomark Res 10(1):63","journal-title":"Biomark Res"},{"key":"5998_CR16","unstructured":"Dong X, Sun H, Mao J, Zhang S Meng C (2021) Differential expression of circular RNA in patients with white matter hyperintensity and cognitive impairment. Zhong Nan Da Xue Xue Bao Yi Xue Ban 46(10):1080\u20139"},{"key":"5998_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/nu14193907","author":"A Mulugeta","year":"2022","unstructured":"Mulugeta A, Navale SS, Lumsden AL, Llewellyn DJHE, Hypponen E (2022) Healthy lifestyle, genetic risk and brain health: a gene-environment interaction study in the UK Biobank. Nutrients. https:\/\/doi.org\/10.3390\/nu14193907","journal-title":"Nutrients"},{"issue":"8","key":"5998_CR18","doi-asserted-by":"publisher","first-page":"5143","DOI":"10.1002\/alz.13859","volume":"20","author":"CR Jack Jr","year":"2024","unstructured":"Jack CR Jr, Andrews JS, Beach TG, Buracchio T, Dunn B, Graf A et al (2024) Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s association workgroup. Alzheimers Dement 20(8):5143\u20135169","journal-title":"Alzheimers Dement"},{"issue":"3","key":"5998_CR19","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SEMPR, McHugh PR (1975) \u201cMini-mental state.\u201d J Psychiatr Res 12(3):189\u2013198","journal-title":"J Psychiatr Res"},{"key":"5998_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/cells13100875","author":"B Polini","year":"2024","unstructured":"Polini B, Zallocco L, Gado F, Ferrisi R, Ricardi C, Zuccarini et al (2024) A proteomic approach identified TFEB as a key player in the protective action of novel CB2R bitopic ligand FD22a against the deleterious effects induced by \u03b2-amyloid in glial cells. Cells. https:\/\/doi.org\/10.3390\/cells13100875","journal-title":"Cells"},{"issue":"4","key":"5998_CR21","doi-asserted-by":"publisher","first-page":"105","DOI":"10.31083\/j.jin2204105","volume":"22","author":"M Ma","year":"2023","unstructured":"Ma M, Xie DZJ, Zhao J (2023) Bioinformatics and experimental identification of circ_0001535 associated with diagnosis and development of Alzheimer\u2019s disease. J Integr Neurosci 22(4):105","journal-title":"J Integr Neurosci"},{"key":"5998_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/biom15091290","author":"J Li","year":"2025","unstructured":"Li J, Wang L, Zhang X, Shi J, Zhu Y, Wang, Zhu X, Zhu Q et al (2025) Translating Alzheimer\u2019s disease mechanisms into therapeutic opportunities. Biomolecules. https:\/\/doi.org\/10.3390\/biom15091290","journal-title":"Biomolecules"},{"key":"5998_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2021.104614","volume":"99","author":"Y Ding","year":"2022","unstructured":"Ding Y, Luan W, Shen X, Wang ZCY, Cao Y (2022) LncRNA BDNF-AS as ceRNA regulates the miR-9-5p\/BACE1 pathway affecting neurotoxicity in Alzheimer\u2019s disease. Arch Gerontol Geriatr 99:104614","journal-title":"Arch Gerontol Geriatr"},{"key":"5998_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/cells12101378","author":"WZY Li","year":"2023","unstructured":"Li WZY, Zheng Y (2023) MicroRNAs in extracellular vesicles of Alzheimer\u2019s disease. Cells. https:\/\/doi.org\/10.3390\/cells12101378","journal-title":"Cells"},{"issue":"2","key":"5998_CR25","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/s41418-021-00865-1","volume":"29","author":"C Song","year":"2022","unstructured":"Song C, Zhang Y, Huang W, Shi J, Huang Q, Jiang M et al (2022) Circular RNA Cwc27 contributes to Alzheimer\u2019s disease pathogenesis by repressing Pur-alpha activity. Cell Death Differ 29(2):393\u2013406","journal-title":"Cell Death Differ"},{"issue":"6","key":"5998_CR26","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1007\/s11064-022-03563-7","volume":"47","author":"S Meng","year":"2022","unstructured":"Meng S, Wang B Li W (2022) CircAXL knockdown alleviates abeta(1\u201342)-induced neurotoxicity in Alzheimer's disease via repressing PDE4A by releasing miR-1306\u20135p. Neurochem Res 47(6):1707\u201320","journal-title":"Neurochem Res"},{"key":"5998_CR27","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.11931","author":"Y Guo","year":"2021","unstructured":"Guo Y, Wang L, Lu J, Jiao J, Yang Y, Zhao et al (2021) Ginsenoside Rg1 improves cognitive capability and affects the microbiota of large intestine of tree shrew model for Alzheimer\u2019s disease. Mol Med Rep. https:\/\/doi.org\/10.3892\/mmr.2021.11931","journal-title":"Mol Med Rep"},{"issue":"5","key":"5998_CR28","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1007\/s10571-022-01274-9","volume":"43","author":"D Nuzzo","year":"2023","unstructured":"Nuzzo D, Frinchi M, Giardina C, Scordino M, Zuccarini M, De Simone C et al (2023) Neuroprotective and antioxidant role of oxotremorine-M, a non-selective muscarinic acetylcholine receptors agonist, in a cellular model of Alzheimer disease. Cell Mol Neurobiol 43(5):1941\u20131956","journal-title":"Cell Mol Neurobiol"},{"issue":"4","key":"5998_CR29","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1111\/jnc.15713","volume":"164","author":"S Mukherjee","year":"2023","unstructured":"Mukherjee S, Dubois C, Perez K, Varghese S, Birchall IE, Leckey M et al (2023) Quantitative proteomics of tau and Abeta in detergent fractions from Alzheimer\u2019s disease brains. J Neurochem 164(4):529\u2013552","journal-title":"J Neurochem"},{"key":"5998_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.850771","author":"M Wei","year":"2022","unstructured":"Wei M, Ye Y, Ali MM, Chamba Y, Tang JSP, Shang P (2022) Effect of fluoride on cytotoxicity involved in mitochondrial dysfunction: a review of mechanism. Front Vet Sci. https:\/\/doi.org\/10.3389\/fvets.2022.850771","journal-title":"Front Vet Sci"},{"key":"5998_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.985363","author":"S Qian","year":"2022","unstructured":"Qian S, Wei Z, Yang W, Huang J, Yang YWJ, Wang J (2022) The role of BCL-2 family proteins in regulating apoptosis and cancer therapy. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2022.985363","journal-title":"Front Oncol"},{"issue":"11","key":"5998_CR32","doi-asserted-by":"publisher","first-page":"7741","DOI":"10.1007\/s12035-019-1638-7","volume":"56","author":"JKY Yap","year":"2019","unstructured":"Yap JKY, Pickard BS, Chan EWLGSY, Gan SY (2019) The role of neuronal NLRP1 inflammasome in Alzheimer\u2019s disease: bringing neurons into the neuroinflammation game. Mol Neurobiol 56(11):7741\u20137753","journal-title":"Mol Neurobiol"},{"issue":"1","key":"5998_CR33","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s11658-024-00657-8","volume":"29","author":"AY Ozdemir","year":"2024","unstructured":"Ozdemir AY, Hofbauerova K, Kopecky V Jr., Novotny JRV, Rudajev V (2024) Different amyloid \u03b242 preparations induce different cell death pathways in the model of SH-SY5Y neuroblastoma cells. Cell Mol Biol Lett 29(1):143","journal-title":"Cell Mol Biol Lett"},{"issue":"1","key":"5998_CR34","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s13195-025-01834-3","volume":"17","author":"J Choi","year":"2025","unstructured":"Choi J, Kim D, Jeong H, Hwang J, Ramalingam M, Han S et al (2025) A novel miR-4536-3p inhibition ameliorates Alzheimer\u2019s disease by reducing Abeta accumulation and tau phosphorylation. Alzheimers Res Ther 17(1):189","journal-title":"Alzheimers Res Ther"},{"key":"5998_CR35","doi-asserted-by":"publisher","first-page":"111187","DOI":"10.1016\/j.exger.2020.111187","volume":"144","author":"Q Liu","year":"2021","unstructured":"Liu Q, Lei C (2021) Neuroprotective effects of miR-331\u20133p through improved cell viability and inflammatory marker expression: Correlation of serum miR-331\u20133p levels with diagnosis and severity of Alzheimer\u2019s disease. Exp Gerontol 144:111187","journal-title":"Exp Gerontol"},{"issue":"5","key":"5998_CR36","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.7150\/thno.47408","volume":"11","author":"ML Chen","year":"2021","unstructured":"Chen ML, Hong CG, Yue T, Li HM, Duan R, Hu WB et al (2021) Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer\u2019s disease by enhancing autophagy. Theranostics 11(5):2395\u20132409","journal-title":"Theranostics"},{"key":"5998_CR37","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1093\/brain\/awv383","volume":"139","author":"QB Zhu","year":"2016","unstructured":"Zhu QB, Unmehopa U, Bossers K, Hu YT, Verwer R, Balesar R et al (2016) MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer\u2019s disease. Brain 139:908\u2013921","journal-title":"Brain"},{"issue":"5","key":"5998_CR38","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/s41422-026-01224-w","volume":"36","author":"L Zhang","year":"2026","unstructured":"Zhang L, Li X, Luo H, Huo Y, Zhou G, Wang P et al (2026) Mitochondrial double-stranded RNA drives aging-associated cognitive decline. Cell Res 36(5):322\u201339","journal-title":"Cell Res"},{"key":"5998_CR39","doi-asserted-by":"crossref","unstructured":"Doser RL LaRocca TJ (2026) Mitochondrial double-stranded RNA accumulation in brain aging and Alzheimer's disease. bioRxiv","DOI":"10.64898\/2026.02.02.703345"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-05998-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-026-05998-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-05998-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:49:28Z","timestamp":1781527768000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-026-05998-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5998"],"URL":"https:\/\/doi.org\/10.1007\/s12035-026-05998-3","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"13 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"695"}}