{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:44:15Z","timestamp":1785757455510,"version":"3.56.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Neuro-Bio Ltd"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-026-06056-8","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:46:20Z","timestamp":1785753980000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Site-selective blocking of a bioactive peptide driving neurodegeneration in the rat brain by its cyclised analogue"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5127-084X","authenticated-orcid":false,"given":"Sibah","family":"Hasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Garcia-Rat\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Greenfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"issue":"3","key":"6056_CR1","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S0306-4522(02)00031-3","volume":"111","author":"T Day","year":"2002","unstructured":"Day T, Greenfield SA (2002) A non-cholinergic, trophic action of acetylcholinesterase on hippocampal neurones in vitro: molecular mechanisms. Neuroscience 111(3):649\u2013656","journal-title":"Neuroscience"},{"key":"6056_CR2","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3389\/fncel.2017.00291","volume":"11","author":"E Brai","year":"2017","unstructured":"Brai E et al (2017) A novel ex vivo model to investigate the underlying mechanisms in Alzheimer\u2019s disease. Front Cell Neurosci 11:291","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"6056_CR3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0165-3806(02)00367-X","volume":"137","author":"EG Duysen","year":"2002","unstructured":"Duysen EG et al (2002) Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse. Brain Res Dev Brain Res 137(1):43\u201354","journal-title":"Brain Res Dev Brain Res"},{"key":"6056_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2022.106260","volume":"149","author":"S Garcia-Rates","year":"2022","unstructured":"Garcia-Rates S, Greenfield S (2022) When a trophic process turns toxic: Alzheimer\u2019s disease as an aberrant recapitulation of a developmental mechanism. Int J Biochem Cell Biol 149:106260","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"6056_CR5","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1523\/JNEUROSCI.11-01-00287.1991","volume":"11","author":"DW Schulz","year":"1991","unstructured":"Schulz DW et al (1991) Autoradiographic localization of putative nicotinic receptors in the rat brain using 125I-neuronal bungarotoxin. J Neurosci 11(1):287\u2013297","journal-title":"J Neurosci"},{"issue":"8","key":"6056_CR6","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.1523\/JNEUROSCI.23-08-03176.2003","volume":"23","author":"JR Wooltorton","year":"2003","unstructured":"Wooltorton JR et al (2003) Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas. J Neurosci 23(8):3176\u20133185","journal-title":"J Neurosci"},{"key":"6056_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113119","author":"SA Greenfield","year":"2022","unstructured":"Greenfield SA et al (2022) Characterization of a bioactive peptide T14 in the human and rodent substantia nigra: implications for neurodegenerative disease. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms232113119","journal-title":"Int J Mol Sci"},{"key":"6056_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2009.01.026","volume":"1263","author":"NP Brooks","year":"2009","unstructured":"Brooks NP, Mexal S, Stitzel JA (2009) Chrna7 genotype is linked with alpha7 nicotinic receptor expression but not alpha7 RNA levels. Brain Res 1263:1\u20139","journal-title":"Brain Res"},{"issue":"3","key":"6056_CR9","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/cne.903490302","volume":"349","author":"E Dominguez del Toro","year":"1994","unstructured":"Dominguez del Toro E et al (1994) Immunocytochemical localization of the alpha 7 subunit of the nicotinic acetylcholine receptor in the rat central nervous system. J Comp Neurol 349(3):325\u2013342","journal-title":"J Comp Neurol"},{"key":"6056_CR10","doi-asserted-by":"publisher","first-page":"362","DOI":"10.3389\/fnins.2018.00362","volume":"12","author":"E Brai","year":"2018","unstructured":"Brai E et al (2018) Modulatory effects of a novel cyclized peptide in reducing the expression of markers linked to Alzheimer\u2019s disease. Front Neurosci 12:362","journal-title":"Front Neurosci"},{"issue":"1","key":"6056_CR11","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12274","volume":"8","author":"SA Greenfield","year":"2022","unstructured":"Greenfield SA et al (2022) A novel process driving Alzheimer\u2019s disease validated in a mouse model: therapeutic potential. Alzheimers Dement (N Y) 8(1):e12274","journal-title":"Alzheimers Dement (N Y)"},{"key":"6056_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114120","volume":"158","author":"S Hasan","year":"2023","unstructured":"Hasan S et al (2023) Antagonising a novel toxin \u201cT14\u201d in Alzheimer\u2019s disease: comparison of receptor blocker versus antibody effects in vitro. Biomed Pharmacother 158:114120","journal-title":"Biomed Pharmacother"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-06056-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-026-06056-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-06056-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:46:20Z","timestamp":1785753980000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-026-06056-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["6056"],"URL":"https:\/\/doi.org\/10.1007\/s12035-026-06056-8","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"20 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal schedule 1 procedures were conducted in accordance with institutional and national ethical guidelines.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare the following competing interests: S.G. is the founder and CEO of Neuro-Bio Limited, and holds shares in the company. S.G.-R. and S.H. are current employees of Neuro-Bio Ltd.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"802"}}