{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:03:43Z","timestamp":1790449423509,"version":"4.1.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-026-06082-6","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T02:07:22Z","timestamp":1785118042000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["miR-124 Ameliorates Spatial Memory Deficits in Rats Exposed to Single-Prolonged Stress by Downregulating IQGAP1 to Regulate Actin-Binding Proteins and Apoptosis in Hippocampal Neurons"],"prefix":"10.1007","volume":"63","author":[{"given":"Qi","family":"An","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yu","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hao","family":"Piao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Ting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Li","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"issue":"25","key":"6082_CR1","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1056\/NEJMra1612499","volume":"376","author":"A Shalev","year":"2017","unstructured":"Shalev A, Liberzon I, Marmar C (2017) Post-traumatic stress disorder. N Engl J Med 376(25):2459\u20132469. https:\/\/doi.org\/10.1056\/NEJMra1612499","journal-title":"N Engl J Med"},{"issue":"2","key":"6082_CR2","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/jmri.26929","volume":"52","author":"A Kunimatsu","year":"2020","unstructured":"Kunimatsu A, Yasaka K, Akai H, Kunimatsu N, Abe O (2020) MRI findings in posttraumatic stress disorder. Journal of magnetic resonance imaging\u202f: JMRI 52(2):380\u2013396. https:\/\/doi.org\/10.1002\/jmri.26929","journal-title":"Journal of magnetic resonance imaging : JMRI"},{"key":"6082_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2020.100217","volume":"12","author":"EL Belleau","year":"2020","unstructured":"Belleau EL, Ehret LE, Hanson JL, Brasel KJ, Larson CL, deRoon-Cassini TA (2020) Amygdala functional connectivity in the acute aftermath of trauma prospectively predicts severity of posttraumatic stress symptoms. Neurobiol Stress 12:100217. https:\/\/doi.org\/10.1016\/j.ynstr.2020.100217","journal-title":"Neurobiol Stress"},{"issue":"3","key":"6082_CR4","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.bpsc.2019.11.003","volume":"5","author":"Z Ben-Zion","year":"2020","unstructured":"Ben-Zion Z, Artzi M, Niry D, Keynan NJ, Zeevi Y, Admon R, Sharon H, Halpern P et al (2020) Neuroanatomical risk factors for posttraumatic stress disorder in recent trauma survivors. Biol Psychiatry Cogn Neurosci Neuroimaging 5(3):311\u2013319. https:\/\/doi.org\/10.1016\/j.bpsc.2019.11.003","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"issue":"2","key":"6082_CR5","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1523\/jneurosci.1506-15.2016","volume":"36","author":"B Mi\u0161i\u0107","year":"2016","unstructured":"Mi\u0161i\u0107 B, Dunkley BT, Sedge PA, Da Costa L, Fatima Z, Berman MG, Doesburg SM, McIntosh AR et al (2016) Post-traumatic stress constrains the dynamic repertoire of neural activity. The Journal of neuroscience\u202f: the official journal of the Society for Neuroscience 36(2):419\u2013431. https:\/\/doi.org\/10.1523\/jneurosci.1506-15.2016","journal-title":"The Journal of neuroscience : the official journal of the Society for Neuroscience"},{"issue":"6","key":"6082_CR6","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/sj.embor.embor867","volume":"4","author":"MW Briggs","year":"2003","unstructured":"Briggs MW, Sacks DB (2003) IQGAP proteins are integral components of cytoskeletal regulation. EMBO Rep 4(6):571\u2013574. https:\/\/doi.org\/10.1038\/sj.embor.embor867","journal-title":"EMBO Rep"},{"issue":"5","key":"6082_CR7","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.tcb.2006.03.002","volume":"16","author":"MD Brown","year":"2006","unstructured":"Brown MD, Sacks DB (2006) IQGAP1 in cellular signaling: bridging the GAP. Trends Cell Biol 16(5):242\u2013249. https:\/\/doi.org\/10.1016\/j.tcb.2006.03.002","journal-title":"Trends Cell Biol"},{"issue":"14","key":"6082_CR8","doi-asserted-by":"publisher","first-page":"12324","DOI":"10.1074\/jbc.M109535200","volume":"277","author":"SC Mateer","year":"2002","unstructured":"Mateer SC, McDaniel AE, Nicolas V, Habermacher GM, Lin MJ, Cromer DA, King ME, Bloom GS (2002) The mechanism for regulation of the F-actin binding activity of IQGAP1 by calcium\/calmodulin. J Biol Chem 277(14):12324\u201312333. https:\/\/doi.org\/10.1074\/jbc.M109535200","journal-title":"J Biol Chem"},{"key":"6082_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1632060","volume":"15","author":"S Zhu","year":"2025","unstructured":"Zhu S, Zou Y, Guo J, Ma W, Lu L, Liu R, Kang J, Zhao K et al (2025) IQGAP1: cross-disease target via receptor-pathway networks. Front Oncol 15:1632060. https:\/\/doi.org\/10.3389\/fonc.2025.1632060","journal-title":"Front Oncol"},{"issue":"23","key":"6082_CR10","doi-asserted-by":"publisher","first-page":"8533","DOI":"10.1523\/jneurosci.1300-11.2011","volume":"31","author":"C Gao","year":"2011","unstructured":"Gao C, Frausto SF, Guedea AL, Tronson NC, Jovasevic V, Leaderbrand K, Corcoran KA, Guzm\u00e1n YF et al (2011) IQGAP1 regulates NR2A signaling, spine density, and cognitive processes. J Neurosci 31(23):8533\u20138542. https:\/\/doi.org\/10.1523\/jneurosci.1300-11.2011","journal-title":"J Neurosci"},{"issue":"4","key":"6082_CR11","doi-asserted-by":"publisher","first-page":"427","DOI":"10.15252\/embr.201439834","volume":"16","author":"AC Hedman","year":"2015","unstructured":"Hedman AC, Smith JM, Sacks DB (2015) The biology of IQGAP proteins: beyond the cytoskeleton. EMBO Rep 16(4):427\u2013446. https:\/\/doi.org\/10.15252\/embr.201439834","journal-title":"EMBO Rep"},{"key":"6082_CR12","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev.neuro.30.051606.094222","volume":"30","author":"VA Alvarez","year":"2007","unstructured":"Alvarez VA, Sabatini BL (2007) Anatomical and physiological plasticity of dendritic spines. Annu Rev Neurosci 30:79\u201397. https:\/\/doi.org\/10.1146\/annurev.neuro.30.051606.094222","journal-title":"Annu Rev Neurosci"},{"issue":"7","key":"6082_CR13","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/s41583-021-00467-3","volume":"22","author":"H Kasai","year":"2021","unstructured":"Kasai H, Ziv NE, Okazaki H, Yagishita S, Toyoizumi T (2021) Spine dynamics in the brain, mental disorders and artificial neural networks. Nat Rev Neurosci 22(7):407\u2013422. https:\/\/doi.org\/10.1038\/s41583-021-00467-3","journal-title":"Nat Rev Neurosci"},{"issue":"6187","key":"6082_CR14","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1126\/science.1252884","volume":"344","author":"BG Wilhelm","year":"2014","unstructured":"Wilhelm BG, Mandad S, Truckenbrodt S, Kr\u00f6hnert K, Sch\u00e4fer C, Rammner B, Koo SJ, Cla\u00dfen GA et al (2014) Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science (New York, NY) 344(6187):1023\u20131028. https:\/\/doi.org\/10.1126\/science.1252884","journal-title":"Science (New York, NY)"},{"key":"6082_CR15","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.mcn.2018.07.001","volume":"91","author":"J Borovac","year":"2018","unstructured":"Borovac J, Bosch M, Okamoto K (2018) Regulation of actin dynamics during structural plasticity of dendritic spines: signaling messengers and actin-binding proteins. Mol Cell Neurosci 91:122\u2013130. https:\/\/doi.org\/10.1016\/j.mcn.2018.07.001","journal-title":"Mol Cell Neurosci"},{"issue":"Pt 10","key":"6082_CR16","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1242\/jcs.02379","volume":"118","author":"J Noritake","year":"2005","unstructured":"Noritake J, Watanabe T, Sato K, Wang S, Kaibuchi K (2005) IQGAP1: a key regulator of adhesion and migration. J Cell Sci 118(Pt 10):2085\u20132092. https:\/\/doi.org\/10.1242\/jcs.02379","journal-title":"J Cell Sci"},{"issue":"2","key":"6082_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056574","volume":"8","author":"I Jausoro","year":"2013","unstructured":"Jausoro I, Mestres I, Quassollo G, Masseroni L, Heredia F, Caceres A (2013) Regulation of spine density and morphology by IQGAP1 protein domains. PLoS ONE 8(2):e56574. https:\/\/doi.org\/10.1371\/journal.pone.0056574","journal-title":"PLoS ONE"},{"key":"6082_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.114154","volume":"356","author":"Y Chen","year":"2022","unstructured":"Chen Y, An Q, Yang ST, Chen YL, Tong L, Ji LL (2022) MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Exp Neurol 356:114154. https:\/\/doi.org\/10.1016\/j.expneurol.2022.114154","journal-title":"Exp Neurol"},{"issue":"1","key":"6082_CR19","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.jpsychires.2009.06.001","volume":"44","author":"J Ding","year":"2010","unstructured":"Ding J, Han F, Shi Y (2010) Single-prolonged stress induces apoptosis in the amygdala in a rat model of post-traumatic stress disorder. J Psychiatr Res 44(1):48\u201355. https:\/\/doi.org\/10.1016\/j.jpsychires.2009.06.001","journal-title":"J Psychiatr Res"},{"issue":"5","key":"6082_CR20","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.neuron.2007.07.034","volume":"55","author":"C Schrick","year":"2007","unstructured":"Schrick C, Fischer A, Srivastava DP, Tronson NC, Penzes P, Radulovic J (2007) N-cadherin regulates cytoskeletally associated IQGAP1\/ERK signaling and memory formation. Neuron 55(5):786\u2013798. https:\/\/doi.org\/10.1016\/j.neuron.2007.07.034","journal-title":"Neuron"},{"issue":"5","key":"6082_CR21","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nrn2373","volume":"9","author":"LA Cingolani","year":"2008","unstructured":"Cingolani LA, Goda Y (2008) Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy. Nat Rev Neurosci 9(5):344\u2013356. https:\/\/doi.org\/10.1038\/nrn2373","journal-title":"Nat Rev Neurosci"},{"key":"6082_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2023.1243524","volume":"17","author":"F Raven","year":"2023","unstructured":"Raven F, Riemersma IW, Olthuis MF, Rybakovaite I, Meijer EL, Meerlo P, Van der Zee EA, Havekes R (2023) Cofilin overactivation improves hippocampus-dependent short-term memory. Front Behav Neurosci 17:1243524. https:\/\/doi.org\/10.3389\/fnbeh.2023.1243524","journal-title":"Front Behav Neurosci"},{"issue":"13","key":"6082_CR23","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1017\/s0033291717000708","volume":"47","author":"KC Koenen","year":"2017","unstructured":"Koenen KC, Ratanatharathorn A, Ng L, McLaughlin KA, Bromet EJ, Stein DJ, Karam EG, Meron Ruscio A et al (2017) Posttraumatic stress disorder in the World Mental Health Surveys. Psychol Med 47(13):2260\u20132274. https:\/\/doi.org\/10.1017\/s0033291717000708","journal-title":"Psychol Med"},{"key":"6082_CR24","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.pnpbp.2018.11.021","volume":"90","author":"S Yoon","year":"2019","unstructured":"Yoon S, Kim YK (2019) Neuroendocrinological treatment targets for posttraumatic stress disorder. Prog Neuropsychopharmacol Biol Psychiatry 90:212\u2013222. https:\/\/doi.org\/10.1016\/j.pnpbp.2018.11.021","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"2","key":"6082_CR25","doi-asserted-by":"publisher","first-page":"e22134","DOI":"10.1002\/syn.22134","volume":"74","author":"X Chen","year":"2020","unstructured":"Chen X, Jiang Y, Wang J, Liu Y, Xiao M, Song C, Bai Y, Yinuo Han N et al (2020) Synapse impairment associated with enhanced apoptosis in post-traumatic stress disorder. Synapse 74(2):e22134. https:\/\/doi.org\/10.1002\/syn.22134","journal-title":"Synapse"},{"issue":"2","key":"6082_CR26","doi-asserted-by":"publisher","first-page":"131","DOI":"10.35946\/arcr.v39.2.04","volume":"39","author":"J Suh","year":"2018","unstructured":"Suh J, Ressler KJ (2018) Common biological mechanisms of alcohol use disorder and post-traumatic stress disorder. Alcohol Res 39(2):131\u2013145","journal-title":"Alcohol Res"},{"issue":"10","key":"6082_CR27","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1038\/nn.4115","volume":"18","author":"S Chattarji","year":"2015","unstructured":"Chattarji S, Tomar A, Suvrathan A, Ghosh S, Rahman MM (2015) Neighborhood matters: divergent patterns of stress-induced plasticity across the brain. Nat Neurosci 18(10):1364\u20131375. https:\/\/doi.org\/10.1038\/nn.4115","journal-title":"Nat Neurosci"},{"key":"6082_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103391","volume":"77","author":"CD Huang","year":"2024","unstructured":"Huang CD, Shi Y, Wang F, Wu PF, Chen JG (2024) Methionine oxidation of actin cytoskeleton attenuates traumatic memory retention via reactivating dendritic spine morphogenesis. Redox Biol 77:103391. https:\/\/doi.org\/10.1016\/j.redox.2024.103391","journal-title":"Redox Biol"},{"issue":"1","key":"6082_CR29","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1091\/mbc.e09-07-0596","volume":"21","author":"F Korobova","year":"2010","unstructured":"Korobova F, Svitkina T (2010) Molecular architecture of synaptic actin cytoskeleton in hippocampal neurons reveals a mechanism of dendritic spine morphogenesis. Mol Biol Cell 21(1):165\u2013176. https:\/\/doi.org\/10.1091\/mbc.e09-07-0596","journal-title":"Mol Biol Cell"},{"issue":"2","key":"6082_CR30","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1083\/jcb.200809046","volume":"185","author":"P Hotulainen","year":"2009","unstructured":"Hotulainen P, Llano O, Smirnov S, Tanhuanp\u00e4\u00e4 K, Faix J, Rivera C, Lappalainen P (2009) Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis. J Cell Biol 185(2):323\u2013339. https:\/\/doi.org\/10.1083\/jcb.200809046","journal-title":"J Cell Biol"},{"issue":"3","key":"6082_CR31","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/bf00711012","volume":"5","author":"RS Cohen","year":"1985","unstructured":"Cohen RS, Chung SK, Pfaff DW (1985) Immunocytochemical localization of actin in dendritic spines of the cerebral cortex using colloidal gold as a probe. Cell Mol Neurobiol 5(3):271\u2013284. https:\/\/doi.org\/10.1007\/bf00711012","journal-title":"Cell Mol Neurobiol"},{"issue":"13","key":"6082_CR32","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1093\/cvr\/cvy205","volume":"114","author":"H Sawada","year":"2018","unstructured":"Sawada H, Wright BC, Chen JZ, Lu HS, Daugherty A (2018) Drebrin: a new player in angiotensin II-induced aortopathies. Cardiovasc Res 114(13):1699\u20131701. https:\/\/doi.org\/10.1093\/cvr\/cvy205","journal-title":"Cardiovasc Res"},{"issue":"6","key":"6082_CR33","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1523\/jneurosci.4091-05.2006","volume":"26","author":"Y Shi","year":"2006","unstructured":"Shi Y, Ethell IM (2006) Integrins control dendritic spine plasticity in hippocampal neurons through NMDA receptor and Ca2+\/calmodulin-dependent protein kinase II-mediated actin reorganization. J Neurosci 26(6):1813\u20131822. https:\/\/doi.org\/10.1523\/jneurosci.4091-05.2006","journal-title":"J Neurosci"},{"issue":"25","key":"6082_CR34","doi-asserted-by":"publisher","first-page":"8129","DOI":"10.1523\/jneurosci.4681-08.2009","volume":"29","author":"Y Shi","year":"2009","unstructured":"Shi Y, Pontrello CG, DeFea KA, Reichardt LF, Ethell IM (2009) Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity. J Neurosci 29(25):8129\u20138142. https:\/\/doi.org\/10.1523\/jneurosci.4681-08.2009","journal-title":"J Neurosci"},{"key":"6082_CR35","doi-asserted-by":"publisher","first-page":"54","DOI":"10.2174\/1874082000903020054","volume":"3","author":"WH Lin","year":"2009","unstructured":"Lin WH, Webb DJ (2009) Actin and actin-binding proteins: masters of dendritic spine formation, morphology, and function. Open Neurosci J 3:54\u201366. https:\/\/doi.org\/10.2174\/1874082000903020054","journal-title":"Open Neurosci J"},{"issue":"8","key":"6082_CR36","doi-asserted-by":"publisher","first-page":"967","DOI":"10.15252\/embj.201796827","volume":"36","author":"S Choi","year":"2017","unstructured":"Choi S, Anderson RA (2017) And Akt-ion! IQGAP1 in control of signaling pathways. EMBO J 36(8):967\u2013969. https:\/\/doi.org\/10.15252\/embj.201796827","journal-title":"EMBO J"},{"key":"6082_CR37","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202205062","author":"L Thines","year":"2023","unstructured":"Thines L, Roushar FJ, Hedman AC, Sacks DB (2023) The IQGAP scaffolds: critical nodes bridging receptor activation to cellular signaling. J Cell Biol. https:\/\/doi.org\/10.1083\/jcb.202205062","journal-title":"J Cell Biol"},{"issue":"2","key":"6082_CR38","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.cellsig.2012.11.001","volume":"25","author":"K Mizuno","year":"2013","unstructured":"Mizuno K (2013) Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation. Cell Signal 25(2):457\u2013469. https:\/\/doi.org\/10.1016\/j.cellsig.2012.11.001","journal-title":"Cell Signal"},{"issue":"1","key":"6082_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06605-8","volume":"7","author":"\u00c1 G\u00f3mez-Mor\u00f3n","year":"2024","unstructured":"G\u00f3mez-Mor\u00f3n \u00c1, Alegre-G\u00f3mez S, Ramirez-Mu\u00f1oz R, Hernaiz-Esteban A, Carrasco-Padilla C, Scagnetti C, Aguilar-Sope\u00f1a \u00d3, Garc\u00eda-Gil M et al (2024) Human T-cell receptor triggering requires inactivation of Lim kinase-1 by Slingshot-1 phosphatase. Commun Biol 7(1):918. https:\/\/doi.org\/10.1038\/s42003-024-06605-8","journal-title":"Commun Biol"},{"issue":"1","key":"6082_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01632-3","volume":"16","author":"R Sollazzo","year":"2024","unstructured":"Sollazzo R, Li Puma DD, Aceto G, Paciello F, Colussi C, Vita MG, Giuffr\u00e8 GM, Pastore F et al (2024) Structural and functional alterations of neurons derived from sporadic Alzheimer\u2019s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis. Alzheimers Res Ther 16(1):267. https:\/\/doi.org\/10.1186\/s13195-024-01632-3","journal-title":"Alzheimers Res Ther"},{"key":"6082_CR41","doi-asserted-by":"publisher","unstructured":"Sexton JA, Potchernikov T, Bibeau JP, Casanova-Sep\u00falveda G, Cao W, Lou HJ, Boggon TJ, De La Cruz EM et al (2023) Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail. bioRxiv. https:\/\/doi.org\/10.1101\/2023.06.30.547189","DOI":"10.1101\/2023.06.30.547189"},{"key":"6082_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23168842","author":"N Mosaddeghzadeh","year":"2022","unstructured":"Mosaddeghzadeh N, Pudewell S, Bazgir F, Kazemein Jasemi NS, Krumbach OHF, Gremer L, Willbold D, Dvorsky R et al (2022) CDC42-IQGAP interactions scrutinized: new insights into the binding properties of the GAP-related domain. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23168842","journal-title":"Int J Mol Sci"},{"issue":"9","key":"6082_CR43","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/s00018-022-04521-w","volume":"79","author":"Y Feng","year":"2022","unstructured":"Feng Y, Chen D, Wang T, Zhou J, Xu W, Xiong H, Bai R, Wu S et al (2022) Sertoli cell survival and barrier function are regulated by miR-181c\/d-Pafah1b1 axis during mammalian spermatogenesis. Cell Mol Life Sci 79(9):498. https:\/\/doi.org\/10.1007\/s00018-022-04521-w","journal-title":"Cell Mol Life Sci"},{"issue":"7","key":"6082_CR44","doi-asserted-by":"publisher","first-page":"2630","DOI":"10.1038\/s41380-023-02126-8","volume":"28","author":"Z Zhu","year":"2023","unstructured":"Zhu Z, Huang X, Du M, Wu C, Fu J, Tan W, Wu B, Zhang J, et al. (2023) Recent advances in the role of miRNAs in post-traumatic stress disorder and traumatic brain injury. Mol Psychiatry 28(7):2630\u20132644. https:\/\/doi.org\/10.1038\/s41380-023-02126-8","journal-title":"Mol Psychiatry"},{"issue":"7","key":"6082_CR45","doi-asserted-by":"publisher","first-page":"3569","DOI":"10.1007\/s12035-023-03271-5","volume":"60","author":"X Gu","year":"2023","unstructured":"Gu X, Xu X, Jia C, Wang J, Zhang J, Gao Q, Chen J (2023) Molecular mechanisms involved in the regulation of neurodevelopment by miR-124. Mol Neurobiol 60(7):3569\u20133583. https:\/\/doi.org\/10.1007\/s12035-023-03271-5","journal-title":"Mol Neurobiol"},{"issue":"7","key":"6082_CR46","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.4103\/nrr.Nrr-d-24-00354","volume":"20","author":"B Martinez","year":"2025","unstructured":"Martinez B, Peplow PV (2025) MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder. Neural Regen Res 20(7):1957\u20131970. https:\/\/doi.org\/10.4103\/nrr.Nrr-d-24-00354","journal-title":"Neural Regen Res"},{"key":"6082_CR47","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.pnpbp.2018.10.010","volume":"89","author":"BW Dunlop","year":"2019","unstructured":"Dunlop BW, Wong A (2019) The hypothalamic-pituitary-adrenal axis in PTSD: pathophysiology and treatment interventions. Prog Neuropsychopharmacol Biol Psychiatry 89:361\u2013379. https:\/\/doi.org\/10.1016\/j.pnpbp.2018.10.010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"6082_CR48","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jpsychires.2025.11.019","volume":"193","author":"Y Funahashi","year":"2026","unstructured":"Funahashi Y, Ochi S, Roy B, Dwivedi Y (2026) Aberrant MicroRNA-124 expression and methylation in the dorsolateral prefrontal cortex of depressed subjects. J Psychiatr Res 193:120\u2013131. https:\/\/doi.org\/10.1016\/j.jpsychires.2025.11.019","journal-title":"J Psychiatr Res"},{"issue":"47","key":"6082_CR49","doi-asserted-by":"publisher","first-page":"E11061","DOI":"10.1073\/pnas.1809609115","volume":"115","author":"KH Yeom","year":"2018","unstructured":"Yeom KH, Mitchell S, Linares AJ, Zheng S, Lin CH, Wang XJ, Hoffmann A, Black DL (2018) Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse. Proc Natl Acad Sci U S A 115(47):E11061-e11070. https:\/\/doi.org\/10.1073\/pnas.1809609115","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6082_CR50","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.998247","volume":"12","author":"KMA Zoheir","year":"2022","unstructured":"Zoheir KMA, Abd-Rabou AA, Darwish AM, Abdelhafez MA, Mahrous KF (2022) Inhibition of induced-hepatic cancer in vivo through IQGAP1-shRNA gene therapy and modulation of TRAIL-induced apoptosis pathway. Front Oncol 12:998247. https:\/\/doi.org\/10.3389\/fonc.2022.998247","journal-title":"Front Oncol"},{"key":"6082_CR51","doi-asserted-by":"publisher","unstructured":"Sato A, Naito T, Hiramoto A, Goda K, Omi T, Kitade Y, Sasaki T, Matsuda A et al (2010) Association of RNase L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line. FEBS J 277(21):4464\u20134473. https:\/\/doi.org\/10.1111\/j.1742-4658.2010.07833.x","DOI":"10.1111\/j.1742-4658.2010.07833.x"},{"key":"6082_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114417","volume":"152","author":"Z Liu","year":"2025","unstructured":"Liu Z, Lin X, Tu Y, Zhou Y, Huang M, Fang C (2025) MALAT1 promotes microglia activation and neuronal apoptosis through via the miR-124-3p\/ SGK1 axis mediating experimental autoimmune encephalomyelitis disease progression in mice. Int Immunopharmacol 152:114417. https:\/\/doi.org\/10.1016\/j.intimp.2025.114417","journal-title":"Int Immunopharmacol"},{"key":"6082_CR53","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-026-03844-w","author":"Y Chen","year":"2026","unstructured":"Chen Y, Wang Y, Fang N, Xu J, Teng Y, Wang K, Huang L, Ni H et al (2026) SGK1 inhibition supports neuroprotection in spinal cord injury by suppressing oxidative stress and AIM2 activation via FoxO1 mediated mitophagy. J Neuroinflammation. https:\/\/doi.org\/10.1186\/s12974-026-03844-w","journal-title":"J Neuroinflammation"},{"key":"6082_CR54","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.bioactmat.2026.01.043","volume":"60","author":"J Zhang","year":"2026","unstructured":"Zhang J, Xiang L, Cai X, Geng Y, Wu Y, Shi J, Zhang H, Hu X et al (2026) 3D-MSCs apoptotic bodies-integrated conductive hydrogel mitigates spinal cord injury via immunoregulation and alleviating neuronal pyroptosis. Bioact Mater 60:704\u2013723. https:\/\/doi.org\/10.1016\/j.bioactmat.2026.01.043","journal-title":"Bioact Mater"},{"issue":"9","key":"6082_CR55","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1038\/s41422-018-0070-2","volume":"28","author":"D Liu","year":"2018","unstructured":"Liu D, Kou X, Chen C, Liu S, Liu Y, Yu W, Yu T, Yang R et al (2018) Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors. Cell Res 28(9):918\u2013933. https:\/\/doi.org\/10.1038\/s41422-018-0070-2","journal-title":"Cell Res"},{"key":"6082_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2026.112571","volume":"145","author":"Z Jiang","year":"2026","unstructured":"Jiang Z, Wu Z, Jin Y, Xu K, Shu W, Wu Y, Ying J, Wu J et al (2026) Astragaloside IV enhances autophagy to suppress endoplasmic reticulum stress and pyroptosis after spinal cord injury. Cell Signal 145:112571. https:\/\/doi.org\/10.1016\/j.cellsig.2026.112571","journal-title":"Cell Signal"},{"issue":"924","key":"6082_CR57","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adr4063","volume":"19","author":"Z Tu","year":"2026","unstructured":"Tu Z, Moses L, Hu Y, Sapkota S, Quintana LM, Guerrero L, Bell GW, Karnoub AE (2026) Stabilization of IQGAP1 by the mTORC2 component PRR5 mediates mitogenic LINC01133-to-ERK signaling in triple-negative breast cancer. Sci Signal 19(924):eadr4063. https:\/\/doi.org\/10.1126\/scisignal.adr4063","journal-title":"Sci Signal"},{"issue":"8","key":"6082_CR58","doi-asserted-by":"publisher","first-page":"6101","DOI":"10.1007\/s12035-024-03936-9","volume":"61","author":"Y Wang","year":"2024","unstructured":"Wang Y, Fang N, Wang Y, Geng Y, Li Y (2024) Activating MC4R promotes functional recovery by repressing oxidative stress-mediated AIM2 activation post-spinal cord injury. Mol Neurobiol 61(8):6101\u20136118. https:\/\/doi.org\/10.1007\/s12035-024-03936-9","journal-title":"Mol Neurobiol"},{"key":"6082_CR59","doi-asserted-by":"publisher","DOI":"10.3390\/bios12070500","author":"D Oprea","year":"2022","unstructured":"Oprea D, Sanz CG, Barsan MM, Enache TA (2022) PC-12 cell line as a neuronal cell model for biosensing applications. Biosensors (Basel). https:\/\/doi.org\/10.3390\/bios12070500","journal-title":"Biosensors (Basel)"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-06082-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-026-06082-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-06082-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T02:07:24Z","timestamp":1785118044000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-026-06082-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["6082"],"URL":"https:\/\/doi.org\/10.1007\/s12035-026-06082-6","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"14 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"792"}}