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Search strategies combined controlled vocabulary (e.g., MeSH terms: Cellular Reprogramming, Epigenomics, Alzheimer's Disease, Regenerative Medicine) with relevant free-text keywords, including \u201castrocyte-to-neuron conversion,\u201d \u201cepigenetic reprogramming,\u201d \u201cin situ neuroregeneration,\u201d \u201cneurological digital twins,\u201d and \u201csenotherapeutics.\u201d Additional terms such as \u201cneuro-immune microenvironment,\u201d \u201csenescence-associated secretory phenotype (SASP),\u201d and \u201cclinical trial\u201d were included to capture studies with broader relevance to neurotherapeutics. Eligible records were limited to peer-reviewed articles, authoritative reviews, and clinical trial reports in English. Titles and abstracts were screened for relevance, followed by a full-text review of selected articles. Reference lists of key papers were examined to identify additional pertinent studies. All references were organized using reference management software and formatted in accordance with the target journal\u2019s style requirements.","order":1,"name":"Ethics","label":"Literature Search and Reference Organization","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"826"}}