{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T18:24:32Z","timestamp":1787423072859,"version":"build-2736575974"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-026-06143-w","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:07:40Z","timestamp":1787378860000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of MicroRNA in Diagnosis of Huntington\u2019s Disease: A Systematic Review"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9809-872X","authenticated-orcid":false,"given":"Sariya","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6361-6586","authenticated-orcid":false,"given":"Husna Irfan","family":"Thalib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2399-1058","authenticated-orcid":false,"given":"Tanveer Nidal","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3681-2873","authenticated-orcid":false,"given":"Kenanah Maher","family":"Alawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6020-5277","authenticated-orcid":false,"given":"Zahra Hussein","family":"Alabdrabalrasol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3985-8931","authenticated-orcid":false,"given":"Fatma E.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"issue":"6","key":"6143_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10061432","volume":"10","author":"A Jurcau","year":"2022","unstructured":"Jurcau A (2022) Molecular pathophysiological mechanisms in Huntington\u2019s disease. Biomedicines 10(6):1432. https:\/\/doi.org\/10.3390\/biomedicines10061432","journal-title":"Biomedicines"},{"key":"6143_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-40","volume":"5","author":"RA Roos","year":"2010","unstructured":"Roos RA (2010) Huntington\u2019s disease: a clinical review. Orphanet J Rare Dis 5:40. https:\/\/doi.org\/10.1186\/1750-1172-5-40","journal-title":"Orphanet J Rare Dis"},{"key":"6143_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00402","volume":"9","author":"J O'Brien","year":"2018","unstructured":"O\u2019Brien J, Hayder H, Zayed Y, Peng C (2018) Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) 9:402. https:\/\/doi.org\/10.3389\/fendo.2018.00402","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"6143_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/cells9020276","volume":"9","author":"CE Condrat","year":"2020","unstructured":"Condrat CE, Thompson DC, Barbu MG, Bugnar OL, Boboc A, Cretoiu D, Suciu N, Cretoiu SM, et al. (2020) MiRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis. Cells 9(2):276. https:\/\/doi.org\/10.3390\/cells9020276","journal-title":"Cells"},{"key":"6143_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.705348","volume":"15","author":"X Dong","year":"2021","unstructured":"Dong X, Cong S (2021) MicroRNAs in Huntington\u2019s disease: diagnostic biomarkers or therapeutic agents? Front Cell Neurosci 15:705348. https:\/\/doi.org\/10.3389\/fncel.2021.705348","journal-title":"Front Cell Neurosci"},{"issue":"20","key":"6143_CR6","doi-asserted-by":"publisher","DOI":"10.1101\/2024.05.20.594947","volume":"05","author":"K Emilia","year":"2024","unstructured":"Emilia K, Agata C, Gra\u017cyna A, Julia S (2024) Fiszer Agnieszka bioRxiv 05(20):594947. https:\/\/doi.org\/10.1101\/2024.05.20.594947","journal-title":"Fiszer Agnieszka bioRxiv"},{"key":"6143_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2024.1399742","volume":"18","author":"A Belkozhayev","year":"2024","unstructured":"Belkozhayev A, Niyazova R, Kamal MA, Ivashchenko A, Sharipov K, Wilson CM (2024) Differential microRNA expression in the SH-SY5Y human cell model as potential biomarkers for Huntington\u2019s disease. Front Cell Neurosci 18:1399742. https:\/\/doi.org\/10.3389\/fncel.2024.1399742","journal-title":"Front Cell Neurosci"},{"issue":"10","key":"6143_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12522","volume":"13","author":"M Herrero-Lorenzo","year":"2024","unstructured":"Herrero-Lorenzo M, P\u00e9rez-P\u00e9rez J, Escaram\u00eds G, Mart\u00ednez-Horta S, P\u00e9rez-Gonz\u00e1lez R, Rivas-Asensio E, Kulisevsky J, G\u00e1mez-Valero A, et al. (2024Oct) Small RNAs in plasma extracellular vesicles define biomarkers of premanifest changes in Huntington\u2019s disease. J Extracell Vesicles 13(10):e12522. https:\/\/doi.org\/10.1002\/jev2.12522","journal-title":"J Extracell Vesicles"},{"issue":"9","key":"6143_CR9","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1080\/15548627.2023.2175572","volume":"19","author":"O Mi","year":"2023","unstructured":"Mi O, Lee SW, Yoo AS (2023Sep) Modeling Huntington disease through microRNA-mediated neuronal reprogramming identifies age-associated autophagy dysfunction driving the onset of neurodegeneration. Autophagy 19(9):2613\u20132615. https:\/\/doi.org\/10.1080\/15548627.2023.2175572","journal-title":"Autophagy"},{"issue":"8","key":"6143_CR10","doi-asserted-by":"publisher","first-page":"934","DOI":"10.22038\/IJBMS.2023.67791.14839","volume":"26","author":"A Moradi","year":"2023","unstructured":"Moradi A, Shahabinezhad F, Dehshahri A (2023) An in silico study to find potential effective circRNAs in the progression of Huntington\u2019s disease. Iran J Basic Med Sci 26(8):934\u2013940. https:\/\/doi.org\/10.22038\/IJBMS.2023.67791.14839","journal-title":"Iran J Basic Med Sci"},{"issue":"20","key":"6143_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012440","volume":"23","author":"S Romano","year":"2022","unstructured":"Romano S, Romano C, Peconi M, Fiore A, Bellucci G, Morena E, Troili F, Cipollini V, et al. (2022) Circulating U13 small nucleolar RNA as a potential biomarker in Huntington\u2019s disease: a pilot study. Int J Mol Sci 23(20):12440. https:\/\/doi.org\/10.3390\/ijms232012440","journal-title":"Int J Mol Sci"},{"issue":"1","key":"6143_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-06970-6","volume":"12","author":"S Guo","year":"2022","unstructured":"Guo S, Yang J, Jiang B, Zhou N, Ding H, Zhou G, Wu S, Suo A, et al. (2022) MicroRNA editing patterns in Huntington\u2019s disease. Sci Rep 12(1):3173. https:\/\/doi.org\/10.1038\/s41598-022-06970-6","journal-title":"Sci Rep"},{"issue":"1","key":"6143_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-022-01407-7","volume":"10","author":"S Petry","year":"2022","unstructured":"Petry S, Keraudren R, Nateghi B, Loiselle A, Pircs K, Jakobsson J, Sephton C, Langlois M, et al. (2022) Widespread alterations in microRNA biogenesis in human Huntington\u2019s disease putamen. Acta Neuropathol Commun 10(1):106. https:\/\/doi.org\/10.1186\/s40478-022-01407-7","journal-title":"Acta Neuropathol Commun"},{"issue":"17","key":"6143_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/cells11172748","volume":"11","author":"RDVS Morais","year":"2022","unstructured":"Morais RDVS, Sogorb-Gonz\u00e1lez M, Bar C, Timmer NC, Van der Bent ML, Wartel M, Vall\u00e8s A (2022) Functional intercellular transmission of miHTT via extracellular vesicles: an in vitro proof-of-mechanism study. Cells 11(17):2748. https:\/\/doi.org\/10.3390\/cells11172748","journal-title":"Cells"},{"issue":"12","key":"6143_CR15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI140723","volume":"131","author":"II Sanchez","year":"2021","unstructured":"Sanchez II, Nguyen TB, England WE, Lim RG, Vu AQ, Miramontes R, Byrne LM, Markmiller S, et al. (2021) Huntington\u2019s disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization. J Clin Invest 131(12):e140723. https:\/\/doi.org\/10.1172\/JCI140723","journal-title":"J Clin Invest"},{"issue":"16","key":"6143_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168424","volume":"22","author":"CC Chang","year":"2021","unstructured":"Chang CC, Tsou SH, Chen WJ, Ho YJ, Hung HC, Liu GY, Singh SK, Li HH, et al. (2021) MiR-302 attenuates mutant huntingtin-induced cytotoxicity through restoration of autophagy and insulin sensitivity. Int J Mol Sci 22(16):8424. https:\/\/doi.org\/10.3390\/ijms22168424","journal-title":"Int J Mol Sci"},{"key":"6143_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.657973","volume":"12","author":"M Ferraldeschi","year":"2021","unstructured":"Ferraldeschi M, Romano S, Giglio S, Romano C, Morena E, Mechelli R, Annibali V, Ubaldi M, et al. (2021) Circulating hsa-miR-323b-3p in Huntington\u2019s disease: a pilot study. Front Neurol 12:657973. https:\/\/doi.org\/10.3389\/fneur.2021.657973","journal-title":"Front Neurol"},{"issue":"2","key":"6143_CR18","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1093\/brain\/awz400","volume":"143","author":"Y Iturria-Medina","year":"2020","unstructured":"Iturria-Medina Y, Khan AF, Adewale Q, Shirazi AH, Alzheimer\u2019s Disease Neuroimaging Initiative (2020) Blood and brain gene expression trajectories mirror neuropathology and clinical deterioration in neurodegeneration. Brain 143(2):661\u2013673. https:\/\/doi.org\/10.1093\/brain\/awz400","journal-title":"Brain"},{"issue":"10","key":"6143_CR19","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1038\/s10038-019-0639-8","volume":"64","author":"KH Kim","year":"2019","unstructured":"Kim KH, Abu Elneel K, Shin JW, Keum JW, Seong D, Kwak S, Lee R, Gusella JF, et al. (2019) Full sequence of mutant huntingtin 3\u2032-untranslated region and modulation of its gene regulatory activity by endogenous microRNA. J Hum Genet 64(10):995\u20131004. https:\/\/doi.org\/10.1038\/s10038-019-0639-8","journal-title":"J Hum Genet"},{"issue":"3","key":"6143_CR20","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/s41593-018-0075-7","volume":"21","author":"MB Victor","year":"2018","unstructured":"Victor MB, Richner M, Olsen HE, Lee SW, Monteys AM, Ma C, Huh CJ, Zhang B, et al. (2018) Striatal neurons directly converted from Huntington\u2019s disease patient fibroblasts recapitulate age-associated disease phenotypes. Nat Neurosci 21(3):341\u2013352. https:\/\/doi.org\/10.1038\/s41593-018-0075-7","journal-title":"Nat Neurosci"},{"issue":"4","key":"6143_CR21","doi-asserted-by":"publisher","first-page":"e264","DOI":"10.1212\/WNL.0000000000004844","volume":"90","author":"ER Reed","year":"2018","unstructured":"Reed ER, Latourelle JC, Bockholt JH, Bregu J, Smock J, Paulsen JS, Myers RH, PREDICT-HD CSF ancillary study investigators (2018) MicroRNAs in CSF as prodromal biomarkers for Huntington disease in the PREDICT-HD study. Neurology 90(4):e264\u2013e272. https:\/\/doi.org\/10.1212\/WNL.0000000000004844","journal-title":"Neurology"},{"issue":"1","key":"6143_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0742-x","volume":"12","author":"KH Chang","year":"2017","unstructured":"Chang KH, Wu YR, Chen CM (2017) Down-regulation of miR-9* in the peripheral leukocytes of Huntington\u2019s disease patients. Orphanet J Rare Dis 12(1):185. https:\/\/doi.org\/10.1186\/s13023-017-0742-x","journal-title":"Orphanet J Rare Dis"},{"issue":"13","key":"6143_CR23","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1016\/j.celrep.2017.09.009","volume":"20","author":"L Romo","year":"2017","unstructured":"Romo L, Ashar-Patel A, Pfister E, Aronin N (2017) Alterations in mRNA 3\u2032 UTR isoform abundance accompany gene expression changes in human Huntington\u2019s disease brains. Cell Rep 20(13):3057\u20133070. https:\/\/doi.org\/10.1016\/j.celrep.2017.09.009","journal-title":"Cell Rep"},{"issue":"1","key":"6143_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-3114-3","volume":"17","author":"C Wake","year":"2016","unstructured":"Wake C, Labadorf A, Dumitriu A, Hoss AG, Bregu J, Albrecht KH, DeStefano AL, Myers RH (2016) Novel microRNA discovery using small RNA sequencing in post-mortem human brain. BMC Genomics 17(1):776. https:\/\/doi.org\/10.1186\/s12864-016-3114-3","journal-title":"BMC Genomics"},{"key":"6143_CR25","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.phrs.2016.05.005","volume":"108","author":"C D\u00edez-Planelles","year":"2016","unstructured":"D\u00edez-Planelles C, S\u00e1nchez-Lozano P, Crespo MC, Gil-Zamorano J, Ribacoba R, Gonz\u00e1lez N, Su\u00e1rez E, Mart\u00ednez-Descals A, et al. (2016) Circulating microRNAs in Huntington\u2019s disease: emerging mediators in metabolic impairment. Pharmacol Res 108:102\u2013110. https:\/\/doi.org\/10.1016\/j.phrs.2016.05.005","journal-title":"Pharmacol Res"},{"issue":"14","key":"6143_CR26","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1002\/mds.26457","volume":"30","author":"AG Hoss","year":"2015","unstructured":"Hoss AG, Lagomarsino VN, Frank S, Hadzi TC, Myers RH, Latourelle JC (2015) Study of plasma-derived miRNAs mimic differences in Huntington\u2019s disease brain. Mov Disord 30(14):1961\u20131964. https:\/\/doi.org\/10.1002\/mds.26457","journal-title":"Mov Disord"},{"issue":"10","key":"6143_CR27","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1038\/ejhg.2014.281","volume":"23","author":"A Mastrokolias","year":"2015","unstructured":"Mastrokolias A, Ariyurek Y, Goeman JJ, van Duijn E, Roos RA, van der Mast RC, van Ommen GB, den Dunnen JT, et al. (2015) Huntington\u2019s disease biomarker progression profile identified by transcriptome sequencing in peripheral blood. Eur J Hum Genet 23(10):1349\u20131356. https:\/\/doi.org\/10.1038\/ejhg.2014.281","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"6143_CR28","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-015-0083-3","volume":"8","author":"AG Hoss","year":"2015","unstructured":"Hoss AG, Labadorf A, Latourelle JC, Kartha VK, Hadzi TC, Gusella JF, MacDonald ME, Chen JF, et al. (2015) MiR-10b-5p expression in Huntington\u2019s disease brain relates to age of onset and the extent of striatal involvement. BMC Med Genomics 8(1):10. https:\/\/doi.org\/10.1186\/s12920-015-0083-3","journal-title":"BMC Med Genomics"},{"issue":"2","key":"6143_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004188","volume":"10","author":"AG Hoss","year":"2014","unstructured":"Hoss AG, Kartha VK, Dong X, Latourelle JC, Dumitriu A, Hadzi TC, Macdonald ME, Gusella JF, et al. (2014) MicroRNAs located in the Hox gene clusters are implicated in Huntington\u2019s disease pathogenesis. PLoS Genet 10(2):e1004188. https:\/\/doi.org\/10.1371\/journal.pgen.1004188","journal-title":"PLoS Genet"},{"issue":"8","key":"6143_CR30","doi-asserted-by":"publisher","first-page":"16999","DOI":"10.3390\/ijms140816999","volume":"14","author":"E Kozlowska","year":"2013","unstructured":"Kozlowska E, Krzyzosiak WJ, Koscianska E (2013) Regulation of huntingtin gene expression by miRNA-137, -214, -148a, and their respective isomiRs. Int J Mol Sci 14(8):16999\u201317016. https:\/\/doi.org\/10.3390\/ijms140816999","journal-title":"Int J Mol Sci"},{"issue":"2","key":"6143_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002481","volume":"8","author":"M Ba\u00f1ez-Coronel","year":"2012","unstructured":"Ba\u00f1ez-Coronel M, Porta S, Kagerbauer B, Mateu-Huertas E, Pantano L, Ferrer I, Guzm\u00e1n M, Estivill X, et al. (2012) A pathogenic mechanism in Huntington\u2019s disease involves small CAG-repeated RNAs with neurotoxic activity. PLoS Genet 8(2):e1002481. https:\/\/doi.org\/10.1371\/journal.pgen.1002481","journal-title":"PLoS Genet"},{"issue":"11","key":"6143_CR32","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1093\/hmg\/ddr111","volume":"20","author":"PM Gaughwin","year":"2011","unstructured":"Gaughwin PM, Ciesla M, Lahiri N, Tabrizi SJ, Brundin P, Bj\u00f6rkqvist M (2011Jun 1) Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington\u2019s disease. Hum Mol Genet 20(11):2225\u20132237. https:\/\/doi.org\/10.1093\/hmg\/ddr111","journal-title":"Hum Mol Genet"},{"issue":"20","key":"6143_CR33","doi-asserted-by":"publisher","first-page":"7219","DOI":"10.1093\/nar\/gkq575","volume":"38","author":"E Mart\u00ed","year":"2010","unstructured":"Mart\u00ed E, Pantano L, Ba\u00f1ez-Coronel M, Llorens F, Mi\u00f1ones-Moyano E, Porta S, Sumoy L, Ferrer I, et al. (2010) A myriad of miRNA variants in control and Huntington\u2019s disease brain regions detected by massively parallel sequencing. Nucleic Acids Res 38(20):7219\u20137235. https:\/\/doi.org\/10.1093\/nar\/gkq575","journal-title":"Nucleic Acids Res"},{"issue":"53","key":"6143_CR34","doi-asserted-by":"publisher","first-page":"14341","DOI":"10.1523\/JNEUROSCI.2390-08.2008","volume":"28","author":"AN Packer","year":"2008","unstructured":"Packer AN, Xing Y, Harper SQ, Jones L, Davidson BL (2008) The bifunctional microRNA miR-9\/miR-9* regulates REST and CoREST and is downregulated in Huntington\u2019s disease. J Neurosci 28(53):14341\u201314346. https:\/\/doi.org\/10.1523\/JNEUROSCI.2390-08.2008","journal-title":"J Neurosci"},{"issue":"3","key":"6143_CR35","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.nbd.2007.11.001","volume":"29","author":"R Johnson","year":"2008","unstructured":"Johnson R, Zuccato C, Belyaev ND, Guest DJ, Cattaneo E, Buckley NJ (2008) A microRNA-based gene dysregulation pathway in Huntington\u2019s disease. Neurobiol Dis 29(3):438\u2013445. https:\/\/doi.org\/10.1016\/j.nbd.2007.11.001","journal-title":"Neurobiol Dis"},{"key":"6143_CR36","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8884642","author":"M He","year":"2021","unstructured":"He M, Zhang HN, Tang ZC, Gao SG (2021) Diagnostic and therapeutic potential of exosomal microRNAs for neurodegenerative diseases. Neural Plast. https:\/\/doi.org\/10.1155\/2021\/8884642","journal-title":"Neural Plast"},{"key":"6143_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.637218","volume":"13","author":"W Xing","year":"2021","unstructured":"Xing W, Gao W, Lv X, Xu X, Zhang Z, Yan J, Mao G, Bu Z (2021) The diagnostic value of exosome-derived biomarkers in Alzheimer\u2019s disease and mild cognitive impairment: a meta-analysis. Front Aging Neurosci 13:637218. https:\/\/doi.org\/10.3389\/fnagi.2021.637218","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"6143_CR38","doi-asserted-by":"publisher","first-page":"45","DOI":"10.14802\/jmd.16054","volume":"10","author":"ST Lee","year":"2017","unstructured":"Lee ST, Im W, Ban JJ, Lee M, Jung KH, Lee SK, Chu K, Kim M (2017) Exosome-based delivery of miR-124 in a Huntington\u2019s disease model. J Mov Disord 10(1):45\u201352. https:\/\/doi.org\/10.14802\/jmd.16054","journal-title":"J Mov Disord"},{"key":"6143_CR39","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.omtm.2019.09.010","volume":"15","author":"S Keskin","year":"2019","unstructured":"Keskin S, Brouwers CC, Sogorb-Gonzalez M, Martier R, Depla JA, Vall\u00e8s A, van Deventer SJ, Konstantinova P, et al. (2019) AAV5-miHTT lowers huntingtin mRNA and protein without off-target effects in patient-derived neuronal cultures and astrocytes. Mol Ther Methods Clin Dev 15:275\u2013284. https:\/\/doi.org\/10.1016\/j.omtm.2019.09.010","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"2","key":"6143_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/biology14020129","volume":"14","author":"S Aqel","year":"2025","unstructured":"Aqel S, Ahmad J, Saleh I, Fathima A, Al Thani AA, Mohamed WMY, Shaito AA (2025) Advances in Huntington\u2019s disease biomarkers: a 10-year bibliometric analysis and a comprehensive review. Biology (Basel) 14(2):129. https:\/\/doi.org\/10.3390\/biology14020129","journal-title":"Biology (Basel)"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-06143-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-026-06143-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-06143-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T18:02:18Z","timestamp":1787421738000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-026-06143-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["6143"],"URL":"https:\/\/doi.org\/10.1007\/s12035-026-06143-w","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"11 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable (NA).","order":1,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"NA.","order":2,"name":"Ethics","label":"Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"NA.","order":3,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"850"}}