{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:17:04Z","timestamp":1788628624987,"version":"build-2803163510"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-026-06165-4","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:50:23Z","timestamp":1788583823000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroprotective Effect of Isorhapontigenin (ISO) Against LPS-Induced Neurodegenerative Condition via TLR4\/RAGE-Mediated p-NF-kB Activation"],"prefix":"10.1007","volume":"63","author":[{"given":"Abubakar","family":"Atiq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyonghwan","family":"Choe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hwa","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzair","family":"Atiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waqas","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waqar","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Ju","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0789-2034","authenticated-orcid":false,"given":"Myeong Ok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"issue":"1","key":"6165_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-95792-3","volume":"15","author":"M K\u00f6m\u00fcr","year":"2025","unstructured":"K\u00f6m\u00fcr M, K\u0131yan HT, \u00d6zt\u00fcrk AA (2025) Development of donepezil hydrochloride-loaded PLGA-based nanoparticles for Alzheimer\u2019s disease treatment. Sci Rep 15(1):13184","journal-title":"Sci Rep"},{"key":"6165_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-026-02320-4","author":"T Nasir","year":"2026","unstructured":"Nasir T et al (2026) Atraric acid enhances neuronal survival and cognition against d-galactose-induced neurodegeneration via BDNF\/TrkB\/AKT signaling. Inflammopharmacology. https:\/\/doi.org\/10.1007\/s10787-026-02320-4","journal-title":"Inflammopharmacology"},{"key":"6165_CR3","unstructured":"Takemiya T, Yamagata K (2007) Effects of COX-2 inhibitors on brain diseases. In: Howardell MJ (ed) Trends in COX-2 Inhibitor Research. Nova Science Publishers, New York, 47\u201375"},{"issue":"6","key":"6165_CR4","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.neuron.2021.12.016","volume":"110","author":"F Brosseron","year":"2022","unstructured":"Brosseron F et al (2022) Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer\u2019s disease. Neuron 110(6):1009-1022.e4","journal-title":"Neuron"},{"key":"6165_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101503","volume":"72","author":"T Song","year":"2021","unstructured":"Song T et al (2021) Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer\u2019s disease: a meta-analysis of in vivo magnetic resonance spectroscopy studies. Ageing Res Rev 72:101503","journal-title":"Ageing Res Rev"},{"issue":"7","key":"6165_CR6","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.bbadis.2015.03.015","volume":"1852","author":"SI Mota","year":"2015","unstructured":"Mota SI et al (2015) Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer\u2019s disease. Biochim Biophys Acta 1852(7):1428\u20131441","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"6165_CR7","doi-asserted-by":"publisher","first-page":"4090","DOI":"10.1021\/acs.jcim.5c00034","volume":"65","author":"M Yan","year":"2025","unstructured":"Yan M et al (2025) Mechanistic insights into the nonenzymatic biosynthesis of artemisinin and related natural products: a quantum chemical study. J Chem Inf Model 65(8):4090\u20134106","journal-title":"J Chem Inf Model"},{"key":"6165_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1209703","volume":"16","author":"H Yu","year":"2023","unstructured":"Yu H, Xiong M, Zhang Z (2023) The role of glycogen synthase kinase 3 beta in neurodegenerative diseases. Front Mol Neurosci 16:1209703","journal-title":"Front Mol Neurosci"},{"key":"6165_CR9","doi-asserted-by":"crossref","unstructured":"Rahmatkar SN and D Singh (2025) Decoding the role of neurotrophins in glycogen synthase kinase 3-beta regulation in Alzheimer\u2019s disease. Molecular Neurobiology 62(7): 8603\u20138623.","DOI":"10.1007\/s12035-025-04776-x"},{"key":"6165_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2021.08.213","volume":"98","author":"M Jiang","year":"2021","unstructured":"Jiang M et al (2021) GSK3\u03b2 is involved in promoting Alzheimer\u2019s disease pathologies following chronic systemic exposure to Porphyromonas gingivalis lipopolysaccharide in amyloid precursor proteinNL-F\/NL-F knock-in mice. Brain Behav Immun 98:1\u201312","journal-title":"Brain Behav Immun"},{"issue":"3","key":"6165_CR11","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s11011-016-9803-4","volume":"31","author":"D Zhou","year":"2016","unstructured":"Zhou D et al (2016) Atorvastatin ameliorates cognitive impairment, A\u03b21-42 production and Tau hyperphosphorylation in APP\/PS1 transgenic mice. Metab Brain Dis 31(3):693\u2013703","journal-title":"Metab Brain Dis"},{"issue":"1","key":"6165_CR12","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s10571-025-01554-0","volume":"45","author":"SM Alqahtani","year":"2025","unstructured":"Alqahtani SM et al (2025) Targeting of PP2 A\/GSK3\u03b2\/PTEN axis in Alzheimer disease: the mooting evidence, divine, and devil. Cell Mol Neurobiol 45(1):36","journal-title":"Cell Mol Neurobiol"},{"issue":"1","key":"6165_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02807-9","volume":"20","author":"MJ Lantz","year":"2023","unstructured":"Lantz MJ et al (2023) The neuroprotective N-terminal amyloid-\u03b2 core hexapeptide reverses reactive gliosis and gliotoxicity in Alzheimer\u2019s disease pathology models. J Neuroinflammation 20(1):129","journal-title":"J Neuroinflammation"},{"key":"6165_CR14","doi-asserted-by":"crossref","unstructured":"Vaara M (2020) Lipopolysaccharide and the permeability of the bacterial outer membrane. Endotoxin in health and disease. CRC Press, pp 31\u201338","DOI":"10.1201\/9781003064961-2"},{"key":"6165_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112566","volume":"223","author":"Y Xing","year":"2021","unstructured":"Xing Y et al (2021) Artemisia ordosica polysaccharide alleviated lipopolysaccharide-induced oxidative stress of broilers via Nrf2\/Keap1 and TLR4\/NF-\u03baB pathway. Ecotoxicol Environ Saf 223:112566","journal-title":"Ecotoxicol Environ Saf"},{"key":"6165_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2021.103667","volume":"289","author":"P Yao","year":"2021","unstructured":"Yao P, Zhang Z, Cao J (2021) Isorhapontigenin alleviates lipopolysaccharide-induced acute lung injury via modulating Nrf2 signaling. Respir Physiol Neurobiol 289:103667","journal-title":"Respir Physiol Neurobiol"},{"issue":"7","key":"6165_CR17","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2143","volume":"11","author":"Z Xue","year":"2021","unstructured":"Xue Z et al (2021) Isorhapontigenin ameliorates cerebral ischemia\/reperfusion injury via modulating Kinase C\u03b5\/Nrf2\/HO-1 signaling pathway. Brain Behav 11(7):e02143","journal-title":"Brain Behav"},{"key":"6165_CR18","doi-asserted-by":"crossref","unstructured":"Guo PF, Zhao J, Zhang BY, Wang C, Bai YM, Liu AL (2025) Isorhapontigenin, a potential anti-AD natural product targeting multiple pathways, discovered via network proximity and gene enrichment analyses. Phytomedicine Plus 5(3):100853","DOI":"10.1016\/j.phyplu.2025.100853"},{"issue":"2","key":"6165_CR19","doi-asserted-by":"publisher","first-page":"49","DOI":"10.31083\/j.jin2102049","volume":"21","author":"NA Alzahrani","year":"2022","unstructured":"Alzahrani NA et al (2022) Investigation of the optimal dose for experimental lipopolysaccharide-induced recognition memory impairment: behavioral and histological studies. J Integr Neurosci 21(2):49","journal-title":"J Integr Neurosci"},{"key":"6165_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2024.114508","volume":"278","author":"S Zeini","year":"2024","unstructured":"Zeini S et al (2024) Resveratrol prevents cognitive impairment and hippocampal inflammatory response induced by lipopolysaccharide in a mouse model of chronic neuroinflammation. Physiol Behav 278:114508","journal-title":"Physiol Behav"},{"issue":"3","key":"6165_CR21","doi-asserted-by":"publisher","first-page":"389","DOI":"10.55782\/ane-2022-037","volume":"82","author":"Q Ma","year":"2022","unstructured":"Ma Q et al (2022) Isorhapontigenin prevents \u03b2-amyloid-associated cognitive impairments through activation of the PI3K\/AKT\/GSK-3\u03b2 pathway. Acta Neurobiol Exp (Wars) 82(3):389\u2013397","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"6165_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1494114","volume":"16","author":"S Ullah","year":"2025","unstructured":"Ullah S et al (2025) Ambroxol attenuates detrimental effect of LPS-induced glia-mediated neuroinflammation, oxidative stress, and cognitive dysfunction in mice brain. Front Immunol 16:1494114","journal-title":"Front Immunol"},{"issue":"12","key":"6165_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24129942","volume":"24","author":"A Atiq","year":"2023","unstructured":"Atiq A et al (2023) Vitamin E analog trolox attenuates MPTP-induced Parkinson\u2019s disease in mice, mitigating oxidative stress, neuroinflammation, and motor impairment. Int J Mol Sci 24(12):9942","journal-title":"Int J Mol Sci"},{"issue":"3","key":"6165_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/biom11030423","volume":"11","author":"S-H Huang","year":"2021","unstructured":"Huang S-H, Fang S-T, Chen Y-C (2021) Molecular mechanism of vitamin K2 protection against amyloid-\u03b2-induced cytotoxicity. Biomolecules 11(3):423","journal-title":"Biomolecules"},{"key":"6165_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2025.115500","author":"Z Zhang","year":"2025","unstructured":"Zhang Z et al (2025) Dl-3-n-butylphthalide reduces urokinase-induced hemorrhagic transformation after stroke by targeting NET-mediated microglial activation. Exp Neurol. https:\/\/doi.org\/10.1016\/j.expneurol.2025.115500","journal-title":"Exp Neurol"},{"key":"6165_CR26","volume":"12","author":"A Khan","year":"2023","unstructured":"Khan A et al (2023) Caffeic acid, a polyphenolic micronutrient rescues mice brains against A\u03b2-induced neurodegeneration and memory impairment. Antioxidants (Basel, Switzerland) 12:1284","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"6165_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2025.1625362","volume":"19","author":"W Ali","year":"2025","unstructured":"Ali W et al (2025) Neuroprotective effects of saikosaponin-A in ethanol-induced glia-mediated neuroinflammation, oxidative stress via RAGE\/TLR4\/NFkB signaling. Front Cell Neurosci 19:1625362","journal-title":"Front Cell Neurosci"},{"key":"6165_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108913","volume":"108","author":"W Ding","year":"2022","unstructured":"Ding W et al (2022) Parthenolide ameliorates neurological deficits and neuroinflammation in mice with traumatic brain injury by suppressing STAT3\/NF-\u03baB and inflammasome activation. Int Immunopharmacol 108:108913","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"6165_CR29","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s12974-022-02565-0","volume":"19","author":"D Singh","year":"2022","unstructured":"Singh D (2022) Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer\u2019s disease. J Neuroinflammation 19(1):206","journal-title":"J Neuroinflammation"},{"issue":"2","key":"6165_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020810","volume":"23","author":"S-L Lee","year":"2022","unstructured":"Lee S-L et al (2022) Erinacine A prevents lipopolysaccharide-mediated glial cell activation to protect dopaminergic neurons against inflammatory factor-induced cell death in vitro and in vivo. Int J Mol Sci 23(2):810","journal-title":"Int J Mol Sci"},{"issue":"1","key":"6165_CR31","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s12035-022-03061-5","volume":"60","author":"P Tiwari","year":"2023","unstructured":"Tiwari P et al (2023) Activation of angiotensin-converting enzyme 2 protects against lipopolysaccharide-induced glial activation by modulating angiotensin-converting enzyme 2\/angiotensin (1\u20137)\/Mas receptor axis. Mol Neurobiol 60(1):203\u2013227","journal-title":"Mol Neurobiol"},{"issue":"1","key":"6165_CR32","volume":"2020","author":"J Wang","year":"2020","unstructured":"Wang J et al (2020) Molecular mechanisms of glial cells related signaling pathways involved in the neuroinflammatory response of depression. Mediators Inflamm 2020(1):3497920","journal-title":"Mediators Inflamm"},{"issue":"8","key":"6165_CR33","doi-asserted-by":"publisher","first-page":"9527","DOI":"10.1007\/s12035-025-04848-y","volume":"62","author":"J Shadman","year":"2025","unstructured":"Shadman J et al (2025) The neuroprotective mechanisms of kaempferol in experimental ischemic stroke: a preclinical systematic review. Mol Neurobiol 62(8):9527\u20139544","journal-title":"Mol Neurobiol"},{"issue":"2","key":"6165_CR34","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1093\/brain\/awae230","volume":"148","author":"H Cai","year":"2025","unstructured":"Cai H et al (2025) Systemic inflammatory markers in ageing, Alzheimer\u2019s disease and other dementias. Brain 148(2):480\u2013492","journal-title":"Brain"},{"key":"6165_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2024.115277","volume":"476","author":"R Heydari","year":"2025","unstructured":"Heydari R et al (2025) A domestic strain of Lactobacillus rhamnosus attenuates cognitive deficit and pro-inflammatory cytokine expression in an animal model of Alzheimer\u2019s disease. Behav Brain Res 476:115277","journal-title":"Behav Brain Res"},{"issue":"1","key":"6165_CR36","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","volume":"47","author":"TW Kensler","year":"2007","unstructured":"Kensler TW, Wakabayashi N, Biswal S (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47(1):89\u2013116","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"6165_CR37","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3389\/fonc.2012.00200","volume":"2","author":"Y Mitsuishi","year":"2012","unstructured":"Mitsuishi Y, Motohashi H, Yamamoto M (2012) The Keap1\u2013Nrf2 system in cancers: stress response and anabolic metabolism. Front Oncol 2:200","journal-title":"Front Oncol"},{"key":"6165_CR38","doi-asserted-by":"crossref","unstructured":"Shareena G, Kumar D, Thorat N (2023) Exploring the diverse roles of GSK-3\u03b2 kinase in Alzheimer\u2019s disease. Deciphering drug targets for Alzheimer\u2019s disease. Springer, pp 219\u2013244","DOI":"10.1007\/978-981-99-2657-2_11"},{"key":"6165_CR39","first-page":"46","volume":"7","author":"M Llorens-Mar\u00edtin","year":"2014","unstructured":"Llorens-Mar\u00edtin M et al (2014) GSK-3\u03b2, a pivotal kinase in Alzheimer disease. Front Mol Neurosci 7:46","journal-title":"Front Mol Neurosci"},{"issue":"4","key":"6165_CR40","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/S0896-6273(02)00706-7","volume":"34","author":"GR Jackson","year":"2002","unstructured":"Jackson GR et al (2002) Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron 34(4):509\u2013519","journal-title":"Neuron"},{"issue":"15","key":"6165_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25158263","volume":"25","author":"F K\u00fchl","year":"2024","unstructured":"K\u00fchl F et al (2024) GSK3-driven modulation of inflammation and tissue integrity in the animal model. Int J Mol Sci 25(15):8263","journal-title":"Int J Mol Sci"},{"issue":"6","key":"6165_CR42","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.tins.2017.04.002","volume":"40","author":"S Forner","year":"2017","unstructured":"Forner S et al (2017) Synaptic impairment in Alzheimer\u2019s disease: a dysregulated symphony. Trends Neurosci 40(6):347\u2013357","journal-title":"Trends Neurosci"},{"key":"6165_CR43","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.pharmthera.2018.11.006","volume":"195","author":"Y Chen","year":"2019","unstructured":"Chen Y, Fu AKY, Ip NY (2019) Synaptic dysfunction in Alzheimer\u2019s disease: mechanisms and therapeutic strategies. Pharmacol Ther 195:186\u2013198","journal-title":"Pharmacol Ther"},{"key":"6165_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012671","author":"Y Zhao","year":"2022","unstructured":"Zhao Y et al (2022) Lipopolysaccharides (LPSs) as potent neurotoxic glycolipids in Alzheimer\u2019s disease (AD). Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms232012671","journal-title":"Int J Mol Sci"},{"issue":"8","key":"6165_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087007","volume":"24","author":"L Yan","year":"2023","unstructured":"Yan L et al (2023) RAGE\u2013TLR4 crosstalk is the key mechanism by which high glucose enhances the lipopolysaccharide-induced inflammatory response in primary bovine alveolar macrophages. Int J Mol Sci 24(8):7007","journal-title":"Int J Mol Sci"},{"issue":"2","key":"6165_CR46","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3390\/cells9020383","volume":"9","author":"YN Paudel","year":"2020","unstructured":"Paudel YN et al (2020) Impact of HMGB1, RAGE, and TLR4 in Alzheimer\u2019s disease (AD): from risk factors to therapeutic targeting. Cells 9(2):383","journal-title":"Cells"},{"issue":"1","key":"6165_CR47","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s10048-025-00821-y","volume":"26","author":"K Abbas","year":"2025","unstructured":"Abbas K et al (2025) Multi-target approach to Alzheimer\u2019s disease prevention and treatment: antioxidant, anti-inflammatory, and amyloid- modulating mechanisms. Neurogenetics 26(1):39","journal-title":"Neurogenetics"},{"issue":"9","key":"6165_CR48","doi-asserted-by":"publisher","first-page":"685","DOI":"10.2174\/0118715273355336250226055826","volume":"24","author":"N Puranik","year":"2025","unstructured":"Puranik N, Song M (2025) Oxidative stress and the role of immune cells in Alzheimer\u2019s disease: therapeutic implications and future perspectives. CNS Neurol Disord Drug Targets 24(9):685\u2013700","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"13\u201315","key":"6165_CR49","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1089\/ars.2023.0234","volume":"38","author":"A Uruno","year":"2023","unstructured":"Uruno A, Yamamoto M (2023) The KEAP1-NRF2 system and neurodegenerative diseases. Antioxid Redox Signal 38(13\u201315):974\u2013988","journal-title":"Antioxid Redox Signal"},{"key":"6165_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911610","author":"L Song","year":"2022","unstructured":"Song L et al (2022) The interplay between GSK3\u03b2 and Tau Ser262 phosphorylation during the progression of tau pathology. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms231911610","journal-title":"Int J Mol Sci"},{"issue":"3","key":"6165_CR51","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1111\/jnc.13351","volume":"135","author":"J Deng","year":"2015","unstructured":"Deng J et al (2015) Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3\u03b2 signaling pathway. J Neurochem 135(3):630\u2013637","journal-title":"J Neurochem"},{"issue":"22","key":"6165_CR52","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.2174\/1389557522666220420094317","volume":"22","author":"N Chauhan","year":"2022","unstructured":"Chauhan N et al (2022) GSK-3\u03b2 and its inhibitors in Alzheimer\u2019s disease: a recent update. Mini Rev Med Chem 22(22):2881\u20132895","journal-title":"Mini Rev Med Chem"},{"key":"6165_CR53","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-025-01717-3","author":"H Jiang","year":"2025","unstructured":"Jiang H et al (2025) Effects of electrical muscle stimulation on cognitive function and neuropathology in senescence-accelerated mouse (SAMP8) model of aging-associated cognitive decline. Geroscience. https:\/\/doi.org\/10.1007\/s11357-025-01717-3","journal-title":"Geroscience"},{"issue":"1","key":"6165_CR54","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s12017-024-08815-z","volume":"27","author":"X Zhuang","year":"2024","unstructured":"Zhuang X et al (2024) The interplay between accumulation of amyloid-beta and tau proteins, panoptosis, and inflammation in Alzheimer\u2019s disease. Neuromolecular Med 27(1):2","journal-title":"Neuromolecular Med"},{"key":"6165_CR55","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12081628","author":"G Plascencia-Villa","year":"2023","unstructured":"Plascencia-Villa G, Perry G (2023) Roles of oxidative stress in synaptic dysfunction and neuronal cell death in Alzheimer\u2019s disease. Antioxidants (Basel). https:\/\/doi.org\/10.3390\/antiox12081628","journal-title":"Antioxidants (Basel)"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-06165-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-026-06165-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-06165-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:02:18Z","timestamp":1788627738000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-026-06165-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["6165"],"URL":"https:\/\/doi.org\/10.1007\/s12035-026-06165-4","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"27 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Clinical Trial Number","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"877"}}