{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:21:54Z","timestamp":1792783314661,"version":"4.5.0"},"reference-count":89,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":265,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Friedrich-Schiller-Universit\u00e4t Jena","id":[{"id":"https:\/\/ror.org\/05qpz1x62","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    During development, the chemokine receptor CXCR4 directs axon guidance, but it is not known if CXCR4 regulates axon targeting in the adult organism as well. We utilized the remarkable feature of the olfactory epithelium to replace damaged neurons throughout life to understand the role of CXCR4 in adult neurogenesis. Through targeting\n                    <jats:italic>Cxcr4<\/jats:italic>\n                    in horizontal basal stem cells of the olfactory epithelium, we investigated the role of CXCR4 during injury-induced neurogenesis in adult mice by a combination of RNA-seq analysis, bioinformatic methods, behavioral experiments, and microscopical approaches. Conditional knockout mice lacking\n                    <jats:italic>Cxcr4<\/jats:italic>\n                    initially displayed enhanced regeneration after injury of the olfactory system, resulting in increased numbers of sensory neurons and enhanced sense of smell. Moreover, we found that absence of CXCR4 alters expression of axon guidance proteins. Despite accelerated early neurogenesis, loss of CXCR4 ultimately impaired the reconstruction of the dorsomedial olfactory epithelium, leading to disrupted glomerular organization and reduced avoidance responses to aversive odors. Transcriptomic analysis revealed altered stress response pathways, suggesting impaired cellular adaptation in\n                    <jats:italic>Cxcr4<\/jats:italic>\n                    -cKO mice during regenerative repair. An increased level of ER stress in horizontal basal cells led to instability of the basal lamina, respiratory metaplasia in the dorsomedial part of the olfactory epithelium, and Bowman gland regeneration failure.\n                  <\/jats:p>","DOI":"10.1007\/s12035-026-06215-x","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:00:08Z","timestamp":1790146808000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CXCR4 Coordinates Long-Term Olfactory Epithelial Regeneration and Cellular Stress Response After Injury"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3063-6936","authenticated-orcid":false,"given":"Katja","family":"Senf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Dietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Karius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3363-1231","authenticated-orcid":false,"given":"Eva M.","family":"Neuhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"issue":"2","key":"6215_CR1","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/0092-8674(93)90422-m","volume":"74","author":"R Vassar","year":"1993","unstructured":"Vassar R, Ngai J, Axel R (1993) Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell 74(2):309\u2013318. https:\/\/doi.org\/10.1016\/0092-8674(93)90422-m","journal-title":"Cell"},{"issue":"3","key":"6215_CR2","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1073\/pnas.0609215104","volume":"104","author":"AT Chesler","year":"2007","unstructured":"Chesler AT, Zou DJ, Le Pichon CE, Peterlin ZA, Matthews GA, Pei X, Miller MC, Firestein S (2007) A G protein\/cAMP signal cascade is required for axonal convergence into olfactory glomeruli. Proc Natl Acad Sci U S A 104(3):1039\u20131044. https:\/\/doi.org\/10.1073\/pnas.0609215104","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5799","key":"6215_CR3","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1126\/science.1131794","volume":"314","author":"T Imai","year":"2006","unstructured":"Imai T, Suzuki M, Sakano H (2006) Odorant receptor-derived cAMP signals direct axonal targeting. Science 314(5799):657\u2013661. https:\/\/doi.org\/10.1126\/science.1131794","journal-title":"Science"},{"key":"6215_CR4","doi-asserted-by":"publisher","unstructured":"Shayya HJ, Kahiapo JK, Duffi\u00e9 R, Lehmann KS, Bashkirova L, Monahan K, Dalton RP, Gao J et al (2022) ER stress transforms random olfactory receptor choice into axon targeting precision. Cell 185(21):3896-3912.e3822. https:\/\/doi.org\/10.1016\/j.cell.2022.08.025","DOI":"10.1016\/j.cell.2022.08.025"},{"issue":"13","key":"6215_CR5","doi-asserted-by":"publisher","first-page":"4334","DOI":"10.1016\/j.celrep.2019.11.099","volume":"29","author":"I Zamparo","year":"2019","unstructured":"Zamparo I, Francia S, Franchi SA, Redolfi N, Costanzi E, Kerstens A, Fukutani Y, Battistutta R et al (2019) Axonal odorant receptors mediate axon targeting. Cell Rep 29(13):4334-4348.e4337. https:\/\/doi.org\/10.1016\/j.celrep.2019.11.099","journal-title":"Cell Rep"},{"key":"6215_CR6","doi-asserted-by":"publisher","unstructured":"Xiang Y, Li Y, Zhang Z, Cui K, Wang S, Yuan XB, Wu CP, Poo MM et al (2002) Nerve growth cone guidance mediated by G protein-coupled receptors. Nat Neurosci 5(9):843\u2013848. https:\/\/doi.org\/10.1038\/nn899","DOI":"10.1038\/nn899"},{"issue":"7","key":"6215_CR7","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1523\/jneurosci.4393-04.2005","volume":"25","author":"Q Li","year":"2005","unstructured":"Li Q, Shirabe K, Thisse C, Thisse B, Okamoto H, Masai I, Kuwada JY (2005) Chemokine signaling guides axons within the retina in zebrafish. J Neurosci 25(7):1711\u20131717. https:\/\/doi.org\/10.1523\/jneurosci.4393-04.2005","journal-title":"J Neurosci"},{"issue":"13","key":"6215_CR8","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1242\/dev.001958","volume":"134","author":"N Miyasaka","year":"2007","unstructured":"Miyasaka N, Knaut H, Yoshihara Y (2007) Cxcl12\/Cxcr4 chemokine signaling is required for placode assembly and sensory axon pathfinding in the zebrafish olfactory system. Development 134(13):2459\u20132468. https:\/\/doi.org\/10.1242\/dev.001958","journal-title":"Development"},{"issue":"4","key":"6215_CR9","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1523\/jneurosci.23-04-01360.2003","volume":"23","author":"SH Chalasani","year":"2003","unstructured":"Chalasani SH, Sabelko KA, Sunshine MJ, Littman DR, Raper JA (2003) A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding. J Neurosci 23(4):1360\u20131371. https:\/\/doi.org\/10.1523\/jneurosci.23-04-01360.2003","journal-title":"J Neurosci"},{"key":"6215_CR10","doi-asserted-by":"publisher","DOI":"10.1242\/dev.202446","author":"VH Le","year":"2024","unstructured":"Le VH, Orniacki C, Murcia-Belmonte V, Denti L, Sch\u00fctz D, Stumm R, Ruhrberg C, Erskine L (2024) CXCL12 promotes the crossing of retinal ganglion cell axons at the optic chiasm. Development. https:\/\/doi.org\/10.1242\/dev.202446","journal-title":"Development"},{"issue":"5","key":"6215_CR11","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.neuron.2005.08.011","volume":"47","author":"I Lieberam","year":"2005","unstructured":"Lieberam I, Agalliu D, Nagasawa T, Ericson J, Jessell TM (2005) A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Neuron 47(5):667\u2013679. https:\/\/doi.org\/10.1016\/j.neuron.2005.08.011","journal-title":"Neuron"},{"issue":"15","key":"6215_CR12","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1002\/jnr.22497","volume":"88","author":"JC McIntyre","year":"2010","unstructured":"McIntyre JC, Titlow WB, McClintock TS (2010) Axon growth and guidance genes identify nascent, immature, and mature olfactory sensory neurons. J Neurosci Res 88(15):3243\u20133256. https:\/\/doi.org\/10.1002\/jnr.22497","journal-title":"J Neurosci Res"},{"issue":"5","key":"6215_CR13","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1002\/stem.3338","volume":"39","author":"K Senf","year":"2021","unstructured":"Senf K, Karius J, Stumm R, Neuhaus EM (2021) Chemokine signaling is required for homeostatic and injury-induced neurogenesis in the olfactory epithelium. Stem Cells 39(5):617\u2013635. https:\/\/doi.org\/10.1002\/stem.3338","journal-title":"Stem Cells"},{"key":"6215_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/cells12172164","author":"A Dietz","year":"2023","unstructured":"Dietz A, Senf K, Karius J, Stumm R, Neuhaus EM (2023) Glia cells control olfactory neurogenesis by fine-tuning CXCL12. Cells. https:\/\/doi.org\/10.3390\/cells12172164","journal-title":"Cells"},{"issue":"22","key":"6215_CR15","doi-asserted-by":"publisher","first-page":"4775","DOI":"10.1242\/dev.127.22.4775","volume":"127","author":"HR Dassule","year":"2000","unstructured":"Dassule HR, Lewis P, Bei M, Maas R, McMahon AP (2000) Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 127(22):4775\u20134785. https:\/\/doi.org\/10.1242\/dev.127.22.4775","journal-title":"Development"},{"issue":"1","key":"6215_CR16","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/cne.903630111","volume":"363","author":"EH Holbrook","year":"1995","unstructured":"Holbrook EH, Szumowski KE, Schwob JE (1995) An immunochemical, ultrastructural, and developmental characterization of the horizontal basal cells of rat olfactory epithelium. J Comp Neurol 363(1):129\u2013146. https:\/\/doi.org\/10.1002\/cne.903630111","journal-title":"J Comp Neurol"},{"issue":"9","key":"6215_CR17","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1084\/jem.20041185","volume":"200","author":"Y Nie","year":"2004","unstructured":"Nie Y, Waite J, Brewer F, Sunshine MJ, Littman DR, Zou YR (2004) The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J Exp Med 200(9):1145\u20131156. https:\/\/doi.org\/10.1084\/jem.20041185","journal-title":"J Exp Med"},{"key":"6215_CR18","doi-asserted-by":"publisher","unstructured":"Dunston D, Ashby S, Krosnowski K, Ogura T, Lin W (2013) An effective manual deboning method to prepare intact mouse nasal tissue with preserved anatomical organization. J Vis Exp (78). https:\/\/doi.org\/10.3791\/50538","DOI":"10.3791\/50538"},{"issue":"3","key":"6215_CR19","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1177\/13.3.211","volume":"13","author":"SS Spicer","year":"1965","unstructured":"Spicer SS (1965) Diamine methods for differentiating mucosubstances histochemically. J Histochem Cytochem 13(3):211\u2013234. https:\/\/doi.org\/10.1177\/13.3.211","journal-title":"J Histochem Cytochem"},{"issue":"8","key":"6215_CR20","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/bf01845800","volume":"21","author":"PE Reid","year":"1989","unstructured":"Reid PE, Owen DA, Fletcher K, Rowan RE, Reimer CL, Rouse GJ, Park CM (1989) The histochemical specificity of high iron diamine-alcian blue. Histochem J 21(8):501\u2013507. https:\/\/doi.org\/10.1007\/bf01845800","journal-title":"Histochem J"},{"issue":"1\u20132","key":"6215_CR21","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0304-3940(93)90509-j","volume":"152","author":"GW Rebeck","year":"1993","unstructured":"Rebeck GW, Marzloff K, Hyman BT (1993) The pattern of NADPH-diaphorase staining, a marker of nitric oxide synthase activity, is altered in the perforant pathway terminal zone in Alzheimer\u2019s disease. Neurosci Lett 152(1\u20132):165\u2013168. https:\/\/doi.org\/10.1016\/0304-3940(93)90509-j","journal-title":"Neurosci Lett"},{"issue":"6716","key":"6215_CR22","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/16729","volume":"397","author":"HP Harding","year":"1999","unstructured":"Harding HP, Zhang Y, Ron D (1999) Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397(6716):271\u2013274. https:\/\/doi.org\/10.1038\/16729","journal-title":"Nature"},{"key":"6215_CR23","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/978-1-60327-040-3_7","volume":"429","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Lee EJ, Jiang J (2008) High-throughput real-time PCR. Methods Mol Biol 429:89\u201398. https:\/\/doi.org\/10.1007\/978-1-60327-040-3_7","journal-title":"Methods Mol Biol"},{"issue":"4","key":"6215_CR24","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/s41593-022-01030-8","volume":"25","author":"IH Wang","year":"2022","unstructured":"Wang IH, Murray E, Andrews G, Jiang HC, Park SJ, Donnard E, Dur\u00e1n-Laforet V, Bear DM et al (2022) Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing. Nat Neurosci 25(4):484\u2013492. https:\/\/doi.org\/10.1038\/s41593-022-01030-8","journal-title":"Nat Neurosci"},{"issue":"13","key":"6215_CR25","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","volume":"184","author":"Y Hao","year":"2021","unstructured":"Hao Y, Hao S, Andersen-Nissen E, Mauck WM 3rd, Zheng S, Butler A, Lee MJ, Wilk AJ et al (2021) Integrated analysis of multimodal single-cell data. Cell 184(13):3573-3587.e3529. https:\/\/doi.org\/10.1016\/j.cell.2021.04.048","journal-title":"Cell"},{"issue":"8","key":"6215_CR26","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","volume":"36","author":"SX Ge","year":"2019","unstructured":"Ge SX, Jung D, Yao R (2019) ShinyGO: a graphical gene-set enrichment tool for animals and plants. Bioinformatics 36(8):2628\u20132629. https:\/\/doi.org\/10.1093\/bioinformatics\/btz931","journal-title":"Bioinformatics"},{"issue":"7949","key":"6215_CR27","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/s41586-022-05688-9","volume":"614","author":"K Kamimoto","year":"2023","unstructured":"Kamimoto K, Stringa B, Hoffmann CM, Jindal K, Solnica-Krezel L, Morris SA (2023) Dissecting cell identity via network inference and in silico gene perturbation. Nature 614(7949):742\u2013751. https:\/\/doi.org\/10.1038\/s41586-022-05688-9","journal-title":"Nature"},{"issue":"1","key":"6215_CR28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s13059-019-1662-y","volume":"20","author":"ATL Lun","year":"2019","unstructured":"Lun ATL, Riesenfeld S, Andrews T, Dao TP, Gomes T, Marioni JC (2019) EmptyDrops: distinguishing cells from empty droplets in droplet-based single-cell RNA sequencing data. Genome Biol 20(1):63. https:\/\/doi.org\/10.1186\/s13059-019-1662-y","journal-title":"Genome Biol"},{"issue":"7993","key":"6215_CR29","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41586-023-06845-4","volume":"625","author":"AD Pourmorady","year":"2024","unstructured":"Pourmorady AD, Bashkirova EV, Chiariello AM, Belagzhal H, Kodra A, Duffie R, Kahiapo J, Monahan K et al (2024) RNA-mediated symmetry breaking enables singular olfactory receptor choice. Nature 625(7993):181\u2013188. https:\/\/doi.org\/10.1038\/s41586-023-06845-4","journal-title":"Nature"},{"issue":"11","key":"6215_CR30","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/s41592-021-01282-5","volume":"18","author":"T Stuart","year":"2021","unstructured":"Stuart T, Srivastava A, Madad S, Lareau CA, Satija R (2021) Single-cell chromatin state analysis with Signac. Nat Methods 18(11):1333\u20131341. https:\/\/doi.org\/10.1038\/s41592-021-01282-5","journal-title":"Nat Methods"},{"issue":"4","key":"6215_CR31","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1093\/bioinformatics\/btz698","volume":"36","author":"AS Bais","year":"2020","unstructured":"Bais AS, Kostka D (2020) Scds: computational annotation of doublets in single-cell RNA sequencing data. Bioinformatics 36(4):1150\u20131158. https:\/\/doi.org\/10.1093\/bioinformatics\/btz698","journal-title":"Bioinformatics"},{"issue":"5","key":"6215_CR32","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.molcel.2018.06.044","volume":"71","author":"HA Pliner","year":"2018","unstructured":"Pliner HA, Packer JS, McFaline-Figueroa JL, Cusanovich DA, Daza RM, Aghamirzaie D, Srivatsan S, Qiu X et al (2018) Cicero predicts cis-regulatory DNA interactions from single-cell chromatin accessibility data. Mol Cell 71(5):858\u2013871. https:\/\/doi.org\/10.1016\/j.molcel.2018.06.044","journal-title":"Mol Cell"},{"issue":"7","key":"6215_CR33","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","volume":"37","author":"AM Newman","year":"2019","unstructured":"Newman AM, Steen CB, Liu CL, Gentles AJ, Chaudhuri AA, Scherer F, Khodadoust MS, Esfahani MS et al (2019) Determining cell type abundance and expression from bulk tissues with digital cytometry. Nat Biotechnol 37(7):773\u2013782. https:\/\/doi.org\/10.1038\/s41587-019-0114-2","journal-title":"Nat Biotechnol"},{"issue":"2","key":"6215_CR34","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","volume":"42","author":"Y Hao","year":"2024","unstructured":"Hao Y, Stuart T, Kowalski MH, Choudhary S, Hoffman P, Hartman A, Srivastava A, Molla G et al (2024) Dictionary learning for integrative, multimodal and scalable single-cell analysis. Nat Biotechnol 42(2):293\u2013304. https:\/\/doi.org\/10.1038\/s41587-023-01767-y","journal-title":"Nat Biotechnol"},{"issue":"4","key":"6215_CR35","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/nmeth.1924","volume":"9","author":"F de Chaumont","year":"2012","unstructured":"de Chaumont F, Coura RD, Serreau P, Cressant A, Chabout J, Granon S, Olivo-Marin JC (2012) Computerized video analysis of social interactions in mice. Nat Methods 9(4):410\u2013417. https:\/\/doi.org\/10.1038\/nmeth.1924","journal-title":"Nat Methods"},{"issue":"2","key":"6215_CR36","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/0896-6273(94)90351-4","volume":"13","author":"M Caggiano","year":"1994","unstructured":"Caggiano M, Kauer JS, Hunter DD (1994) Globose basal cells are neuronal progenitors in the olfactory epithelium: a lineage analysis using a replication-incompetent retrovirus. Neuron 13(2):339\u2013352","journal-title":"Neuron"},{"key":"6215_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF01206454","volume":"8","author":"P Graziadei","year":"1979","unstructured":"Graziadei P, Monti Graziadei G (1979) Neurogenesis and neuron regeneration in the olfactory system of mammals. I. Differentiation and structural organization of the olfactory sensory neurons. J Neurocytol 8:1\u201318","journal-title":"J Neurocytol"},{"issue":"6","key":"6215_CR38","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1093\/chemse\/19.6.671","volume":"19","author":"JE Schwob","year":"1994","unstructured":"Schwob JE, Huard JM, Luskin MB, Youngentob SL (1994) Retroviral lineage studies of the rat olfactory epithelium. Chem Senses 19(6):671\u2013682","journal-title":"Chem Senses"},{"issue":"5","key":"6215_CR39","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.neuron.2011.09.009","volume":"72","author":"B Fletcher Russell","year":"2011","unstructured":"Fletcher Russell B, Prasol Melanie S, Estrada J, Baudhuin A, Vranizan K, Choi Yoon G, Ngai J (2011) p63 regulates olfactory stem cell self-renewal and differentiation. Neuron 72(5):748\u2013759. https:\/\/doi.org\/10.1016\/j.neuron.2011.09.009","journal-title":"Neuron"},{"issue":"1","key":"6215_CR40","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/cne.903590103","volume":"359","author":"JE Schwob","year":"1995","unstructured":"Schwob JE, Youngentob SL, Mezza RC (1995) Reconstitution of the rat olfactory epithelium after methyl bromide-induced lesion. J Comp Neurol 359(1):15\u201337","journal-title":"J Comp Neurol"},{"issue":"6","key":"6215_CR41","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/nn1882","volume":"10","author":"CT Leung","year":"2007","unstructured":"Leung CT, Coulombe PA, Reed RR (2007) Contribution of olfactory neural stem cells to tissue maintenance and regeneration. Nat Neurosci 10(6):720\u2013726","journal-title":"Nat Neurosci"},{"issue":"5","key":"6215_CR42","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1634\/stemcells.2007-0891","volume":"26","author":"N Iwai","year":"2008","unstructured":"Iwai N, Zhou Z, Roop DR, Behringer RR (2008) Horizontal basal cells are multipotent progenitors in normal and injured adult olfactory epithelium. Stem Cells 26(5):1298\u20131306. https:\/\/doi.org\/10.1634\/stemcells.2007-0891","journal-title":"Stem Cells"},{"issue":"24","key":"6215_CR43","doi-asserted-by":"publisher","first-page":"8748","DOI":"10.1523\/jneurosci.0681-11.2011","volume":"31","author":"A Packard","year":"2011","unstructured":"Packard A, Schnittke N, Romano RA, Sinha S, Schwob JE (2011) DeltaNp63 regulates stem cell dynamics in the mammalian olfactory epithelium. J Neurosci 31(24):8748\u20138759. https:\/\/doi.org\/10.1523\/jneurosci.0681-11.2011","journal-title":"J Neurosci"},{"issue":"9","key":"6215_CR44","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1111\/j.0953-816X.2004.03331.x","volume":"19","author":"F Gussing","year":"2004","unstructured":"Gussing F, Bohm S (2004) NQO1 activity in the main and the accessory olfactory systems correlates with the zonal topography of projection maps. Eur J Neurosci 19(9):2511\u20132518. https:\/\/doi.org\/10.1111\/j.0953-816X.2004.03331.x","journal-title":"Eur J Neurosci"},{"issue":"4","key":"6215_CR45","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.mcn.2007.01.014","volume":"34","author":"J Hirota","year":"2007","unstructured":"Hirota J, Omura M, Mombaerts P (2007) Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse. Mol Cell Neurosci 34(4):679\u2013688. https:\/\/doi.org\/10.1016\/j.mcn.2007.01.014","journal-title":"Mol Cell Neurosci"},{"issue":"21","key":"6215_CR46","doi-asserted-by":"publisher","first-page":"5319","DOI":"10.1242\/dev.01416","volume":"131","author":"A Kolterud","year":"2004","unstructured":"Kolterud A, Alenius M, Carlsson L, Bohm S (2004) The Lim homeobox gene Lhx2 is required for olfactory sensory neuron identity. Development 131(21):5319\u20135326. https:\/\/doi.org\/10.1242\/dev.01416","journal-title":"Development"},{"issue":"48","key":"6215_CR47","doi-asserted-by":"publisher","first-page":"84595","DOI":"10.18632\/oncotarget.21102","volume":"8","author":"TK Sears","year":"2017","unstructured":"Sears TK, Angelastro JM (2017) The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. Oncotarget 8(48):84595\u201384609. https:\/\/doi.org\/10.18632\/oncotarget.21102","journal-title":"Oncotarget"},{"issue":"45","key":"6215_CR48","doi-asserted-by":"publisher","first-page":"18589","DOI":"10.1073\/pnas.1210479109","volume":"109","author":"SZ Wang","year":"2012","unstructured":"Wang SZ, Ou J, Zhu LJ, Green MR (2012) Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons. Proc Natl Acad Sci U S A 109(45):18589\u201318594. https:\/\/doi.org\/10.1073\/pnas.1210479109","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"6215_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78107-6","volume":"10","author":"JM Seckler","year":"2020","unstructured":"Seckler JM, Shen J, Lewis THJ, Abdulameer MA, Zaman K, Palmer LA, Bates JN, Jenkins MW et al (2020) NADPH diaphorase detects S-nitrosylated proteins in aldehyde-treated biological tissues. Sci Rep 10(1):21088. https:\/\/doi.org\/10.1038\/s41598-020-78107-6","journal-title":"Sci Rep"},{"issue":"6","key":"6215_CR50","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.stem.2017.10.014","volume":"21","author":"L Gadye","year":"2017","unstructured":"Gadye L, Das D, Sanchez MA, Street K, Baudhuin A, Wagner A, Cole MB, Choi YG et al (2017) Injury activates transient olfactory stem cell states with diverse lineage capacities. Cell Stem Cell 21(6):775-790.e779. https:\/\/doi.org\/10.1016\/j.stem.2017.10.014","journal-title":"Cell Stem Cell"},{"key":"6215_CR51","doi-asserted-by":"publisher","DOI":"10.1523\/eneuro.0266-19.2019","author":"T Liberia","year":"2019","unstructured":"Liberia T, Martin-Lopez E, Meller SJ, Greer CA (2019) Sequential maturation of olfactory sensory neurons in the mature olfactory epithelium. eNeuro. https:\/\/doi.org\/10.1523\/eneuro.0266-19.2019","journal-title":"eNeuro"},{"issue":"6","key":"6215_CR52","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/j.1601-183X.2006.00281.x","volume":"6","author":"SR Wersinger","year":"2007","unstructured":"Wersinger SR, Caldwell HK, Martinez L, Gold P, Hu S-B, Young WS 3rd (2007) Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression. Genes Brain Behav 6(6):540\u2013551. https:\/\/doi.org\/10.1111\/j.1601-183X.2006.00281.x","journal-title":"Genes Brain Behav"},{"key":"6215_CR53","doi-asserted-by":"publisher","unstructured":"Hills M, Ma L, Fang A, Chiremba T, Malloy S, Scott A, Perera A, Yu CR (2024) Molecular, cellular, and developmental organization of the mouse vomeronasal organ at single cell resolution. bioRxiv. https:\/\/doi.org\/10.1101\/2024.02.22.581574","DOI":"10.1101\/2024.02.22.581574"},{"issue":"16","key":"6215_CR54","doi-asserted-by":"publisher","first-page":"3391","DOI":"10.1002\/cne.24259","volume":"525","author":"JH Coleman","year":"2017","unstructured":"Coleman JH, Lin B, Schwob JE (2017) Dissecting LSD1-dependent neuronal maturation in the olfactory epithelium. J Comp Neurol 525(16):3391\u20133413. https:\/\/doi.org\/10.1002\/cne.24259","journal-title":"J Comp Neurol"},{"issue":"92","key":"6215_CR55","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2013.0950","volume":"11","author":"G Hong","year":"2014","unstructured":"Hong G, Zhang W, Li H, Shen X, Guo Z (2014) Separate enrichment analysis of pathways for up- and downregulated genes. J R Soc Interface 11(92):20130950. https:\/\/doi.org\/10.1098\/rsif.2013.0950","journal-title":"J R Soc Interface"},{"issue":"34","key":"6215_CR56","doi-asserted-by":"publisher","first-page":"9094","DOI":"10.1523\/jneurosci.2217-07.2007","volume":"27","author":"JH Cho","year":"2007","unstructured":"Cho JH, L\u00e9pine M, Andrews W, Parnavelas J, Cloutier JF (2007) Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb. J Neurosci 27(34):9094\u20139104. https:\/\/doi.org\/10.1523\/jneurosci.2217-07.2007","journal-title":"J Neurosci"},{"issue":"5","key":"6215_CR57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064975","volume":"8","author":"W Mueller","year":"2013","unstructured":"Mueller W, Sch\u00fctz D, Nagel F, Schulz S, Stumm R (2013) Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus. PLoS ONE 8(5):e64975. https:\/\/doi.org\/10.1371\/journal.pone.0064975","journal-title":"PLoS ONE"},{"issue":"14","key":"6215_CR58","doi-asserted-by":"publisher","first-page":"3586","DOI":"10.1523\/jneurosci.0324-05.2005","volume":"25","author":"K Miyamichi","year":"2005","unstructured":"Miyamichi K, Serizawa S, Kimura HM, Sakano H (2005) Continuous and overlapping expression domains of odorant receptor genes in the olfactory epithelium determine the dorsal\/ventral positioning of glomeruli in the olfactory bulb. J Neurosci 25(14):3586\u20133592. https:\/\/doi.org\/10.1523\/jneurosci.0324-05.2005","journal-title":"J Neurosci"},{"issue":"1","key":"6215_CR59","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/s0092-8674(00)81145-9","volume":"93","author":"F Wang","year":"1998","unstructured":"Wang F, Nemes A, Mendelsohn M, Axel R (1998) Odorant receptors govern the formation of a precise topographic map. Cell 93(1):47\u201360. https:\/\/doi.org\/10.1016\/s0092-8674(00)81145-9","journal-title":"Cell"},{"issue":"7169","key":"6215_CR60","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/nature06281","volume":"450","author":"K Kobayakawa","year":"2007","unstructured":"Kobayakawa K, Kobayakawa R, Matsumoto H, Oka Y, Imai T, Ikawa M, Okabe M, Ikeda T et al (2007) Innate versus learned odour processing in the mouse olfactory bulb. Nature 450(7169):503\u2013508. https:\/\/doi.org\/10.1038\/nature06281","journal-title":"Nature"},{"issue":"4","key":"6215_CR61","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.jaci.2019.01.052","volume":"144","author":"JL Everman","year":"2019","unstructured":"Everman JL, Sajuthi S, Saef B, Rios C, Stoner AM, Numata M, Hu D, Eng C et al (2019) Functional genomics of CDHR3 confirms its role in HRV-C infection and childhood asthma exacerbations. J Allergy Clin Immunol 144(4):962\u2013971. https:\/\/doi.org\/10.1016\/j.jaci.2019.01.052","journal-title":"J Allergy Clin Immunol"},{"issue":"D1","key":"6215_CR62","doi-asserted-by":"publisher","first-page":"D938","DOI":"10.1093\/nar\/gkad1082","volume":"52","author":"TE Putman","year":"2023","unstructured":"Putman TE, Schaper K, Matentzoglu N, Rubinetti VP, Alquaddoomi FS, Cox C, Caufield JH, Elsarboukh G et al (2023) The Monarch Initiative in 2024: an analytic platform integrating phenotypes, genes and diseases across species. Nucleic Acids Res 52(D1):D938\u2013D949. https:\/\/doi.org\/10.1093\/nar\/gkad1082","journal-title":"Nucleic Acids Res"},{"issue":"21","key":"6215_CR63","doi-asserted-by":"publisher","first-page":"4116","DOI":"10.1523\/jneurosci.2468-19.2020","volume":"40","author":"S H\u00e5glin","year":"2020","unstructured":"H\u00e5glin S, Berghard A, Bohm S (2020) Increased retinoic acid catabolism in olfactory sensory neurons activates dormant tissue-specific stem cells and accelerates age-related metaplasia. J Neurosci 40(21):4116\u20134129. https:\/\/doi.org\/10.1523\/jneurosci.2468-19.2020","journal-title":"J Neurosci"},{"issue":"1","key":"6215_CR64","doi-asserted-by":"publisher","DOI":"10.1038\/srep38199","volume":"6","author":"P-L Weng","year":"2016","unstructured":"Weng P-L, Vinjamuri M, Ovitt CE (2016) Ascl3 transcription factor marks a distinct progenitor lineage for non-neuronal support cells in the olfactory epithelium. Sci Rep 6(1):38199. https:\/\/doi.org\/10.1038\/srep38199","journal-title":"Sci Rep"},{"issue":"8","key":"6215_CR65","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1002\/dneu.20796","volume":"70","author":"O Lerner","year":"2010","unstructured":"Lerner O, Davenport D, Patel P, Psatha M, Lieberam I, Guthrie S (2010) Stromal cell-derived factor-1 and hepatocyte growth factor guide axon projections to the extraocular muscles. Dev Neurobiol 70(8):549\u2013564. https:\/\/doi.org\/10.1002\/dneu.20796","journal-title":"Dev Neurobiol"},{"issue":"12","key":"6215_CR66","doi-asserted-by":"publisher","first-page":"5201","DOI":"10.1167\/iovs.18-25190","volume":"59","author":"MC Whitman","year":"2018","unstructured":"Whitman MC, Nguyen EH, Bell JL, Tenney AP, Gelber A, Engle EC (2018) Loss of CXCR4\/CXCL12 signaling causes oculomotor nerve misrouting and development of motor trigeminal to oculomotor synkinesis. Invest Ophthalmol Vis Sci 59(12):5201\u20135209. https:\/\/doi.org\/10.1167\/iovs.18-25190","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6215_CR67","doi-asserted-by":"publisher","DOI":"10.1242\/dev.201289","author":"V Halasy","year":"2023","unstructured":"Halasy V, Sz\u0151cs E, So\u00f3s \u00c1, Kov\u00e1cs T, Pecsenye-Fejsz\u00e1k N, Hotta R, Goldstein AM, Nagy N (2023) CXCR4 and CXCL12 signaling regulates the development of extrinsic innervation to the colorectum. Development. https:\/\/doi.org\/10.1242\/dev.201289","journal-title":"Development"},{"issue":"8","key":"6215_CR68","doi-asserted-by":"publisher","first-page":"3464","DOI":"10.1096\/fj.12-206193","volume":"26","author":"A Berghard","year":"2012","unstructured":"Berghard A, H\u00e4gglund AC, Bohm S, Carlsson L (2012) Lhx2-dependent specification of olfactory sensory neurons is required for successful integration of olfactory, vomeronasal, and GnRH neurons. Faseb J 26(8):3464\u20133472. https:\/\/doi.org\/10.1096\/fj.12-206193","journal-title":"Faseb J"},{"issue":"18","key":"6215_CR69","doi-asserted-by":"publisher","first-page":"3597","DOI":"10.1007\/s00018-019-03385-x","volume":"77","author":"YZ Wang","year":"2020","unstructured":"Wang YZ, Fan H, Ji Y, Reynolds K, Gu R, Gan Q, Yamagami T, Zhao T et al (2020) Olig2 regulates terminal differentiation and maturation of peripheral olfactory sensory neurons. Cell Mol Life Sci 77(18):3597\u20133609. https:\/\/doi.org\/10.1007\/s00018-019-03385-x","journal-title":"Cell Mol Life Sci"},{"key":"6215_CR70","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28620","author":"K Monahan","year":"2017","unstructured":"Monahan K, Schieren I, Cheung J, Mumbey-Wafula A, Monuki ES, Lomvardas S (2017) Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons. Elife. https:\/\/doi.org\/10.7554\/eLife.28620","journal-title":"Elife"},{"issue":"1","key":"6215_CR71","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33967-6","volume":"13","author":"JS Huang","year":"2022","unstructured":"Huang JS, Kunkhyen T, Rangel AN, Brechbill TR, Gregory JD, Winson-Bushby ED, Liu B, Avon JT et al (2022) Immature olfactory sensory neurons provide behaviourally relevant sensory input to the olfactory bulb. Nat Commun 13(1):6194. https:\/\/doi.org\/10.1038\/s41467-022-33967-6","journal-title":"Nat Commun"},{"key":"6215_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.03.021","author":"J-L Yang","year":"2020","unstructured":"Yang J-L, Bertolesi G, Hehr C, McFarlane S (2020) Lhx2\/9 and Etv1 transcription factors have complementary roles in regulating the expression of guidance genes slit1 and sema3a. Neuroscience. https:\/\/doi.org\/10.1016\/j.neuroscience.2020.03.021","journal-title":"Neuroscience"},{"issue":"13","key":"6215_CR73","doi-asserted-by":"publisher","first-page":"4372","DOI":"10.1523\/jneurosci.5851-11.2012","volume":"32","author":"P Marcos-Mond\u00e9jar","year":"2012","unstructured":"Marcos-Mond\u00e9jar P, Peregr\u00edn S, Li JY, Carlsson L, Tole S, L\u00f3pez-Bendito G (2012) The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors. J Neurosci 32(13):4372\u20134385. https:\/\/doi.org\/10.1523\/jneurosci.5851-11.2012","journal-title":"J Neurosci"},{"issue":"2","key":"6215_CR74","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.cell.2013.09.033","volume":"155","author":"RP Dalton","year":"2013","unstructured":"Dalton RP, Lyons DB, Lomvardas S (2013) Co-opting the unfolded protein response to elicit olfactory receptor feedback. Cell 155(2):321\u2013332. https:\/\/doi.org\/10.1016\/j.cell.2013.09.033","journal-title":"Cell"},{"key":"6215_CR75","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1749-8104-7-17","volume":"7","author":"TK Knott","year":"2012","unstructured":"Knott TK, Madany PA, Faden AA, Xu M, Strotmann J, Henion TR, Schwarting GA (2012) Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance. Neural Dev 7:17. https:\/\/doi.org\/10.1186\/1749-8104-7-17","journal-title":"Neural Dev"},{"issue":"6","key":"6215_CR76","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.neuron.2008.10.046","volume":"60","author":"A Fleischmann","year":"2008","unstructured":"Fleischmann A, Shykind BM, Sosulski DL, Franks KM, Glinka ME, Mei DF, Sun Y, Kirkland J et al (2008) Mice with a \u201cmonoclonal nose\u201d: perturbations in an olfactory map impair odor discrimination. Neuron 60(6):1068\u20131081. https:\/\/doi.org\/10.1016\/j.neuron.2008.10.046","journal-title":"Neuron"},{"issue":"2","key":"6215_CR77","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1002\/cne.23665","volume":"523","author":"DA Amaya","year":"2015","unstructured":"Amaya DA, Wegner M, Stolt CC, Chehrehasa F, Ekberg JA, St John JA (2015) Radial glia phagocytose axonal debris from degenerating overextending axons in the developing olfactory bulb. J Comp Neurol 523(2):183\u2013196. https:\/\/doi.org\/10.1002\/cne.23665","journal-title":"J Comp Neurol"},{"issue":"1","key":"6215_CR78","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13064-017-0079-0","volume":"12","author":"IN Eerdunfu","year":"2017","unstructured":"Eerdunfu IN, Ligao B, Ikegaya Y, Takeuchi H (2017) Differential timing of neurogenesis underlies dorsal-ventral topographic projection of olfactory sensory neurons. Neural Dev 12(1):2. https:\/\/doi.org\/10.1186\/s13064-017-0079-0","journal-title":"Neural Dev"},{"issue":"3","key":"6215_CR79","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/S0022-3565(25)10486-2","volume":"263","author":"MB Genter","year":"1992","unstructured":"Genter MB, Llorens J, O\u2019Callaghan JP, Peele DB, Morgan KT, Crofton KM (1992) Olfactory toxicity of \u03b2,\u03b2\u2032-iminodipropionitrile in the rat. J Pharmacol Exp Ther 263(3):1432\u20131439","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"6215_CR80","doi-asserted-by":"publisher","first-page":"981","DOI":"10.3390\/antiox12050981","volume":"12","author":"G Ong","year":"2023","unstructured":"Ong G, Logue SE (2023) Unfolding the interactions between endoplasmic reticulum stress and oxidative stress. Antioxidants (Basel) 12(5):981","journal-title":"Antioxidants (Basel)"},{"key":"6215_CR81","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101950","volume":"41","author":"D Ross","year":"2021","unstructured":"Ross D, Siegel D (2021) The diverse functionality of NQO1 and its roles in redox control. Redox Biol 41:101950. https:\/\/doi.org\/10.1016\/j.redox.2021.101950","journal-title":"Redox Biol"},{"issue":"9","key":"6215_CR82","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.neurobiolaging.2003.12.010","volume":"25","author":"FL van Muiswinkel","year":"2004","unstructured":"van Muiswinkel FL, de Vos RA, Bol JG, Andringa G, Jansen Steur EN, Ross D, Siegel D, Drukarch B (2004) Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra. Neurobiol Aging 25(9):1253\u20131262. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2003.12.010","journal-title":"Neurobiol Aging"},{"key":"6215_CR83","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.831116","volume":"15","author":"APK Wodrich","year":"2022","unstructured":"Wodrich APK, Scott AW, Shukla AK, Harris BT, Giniger E (2022) The unfolded protein responses in health, aging, and neurodegeneration: recent advances and future considerations. Front Mol Neurosci 15:831116. https:\/\/doi.org\/10.3389\/fnmol.2022.831116","journal-title":"Front Mol Neurosci"},{"issue":"17","key":"6215_CR84","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1002\/1873-3468.14995","volume":"598","author":"DF Santos","year":"2024","unstructured":"Santos DF, Sim\u00e3o S, N\u00f3brega C, Bragan\u00e7a J, Castelo-Branco P, Ara\u00fajo IM, Consortium AS (2024) Oxidative stress and aging: synergies for age related diseases. FEBS Lett 598(17):2074\u20132091. https:\/\/doi.org\/10.1002\/1873-3468.14995","journal-title":"FEBS Lett"},{"issue":"1","key":"6215_CR85","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s10571-024-01487-0","volume":"44","author":"S Davinelli","year":"2024","unstructured":"Davinelli S, Medoro A, Savino R, Scapagnini G (2024) Sleep and oxidative stress: current perspectives on the role of NRF2. Cell Mol Neurobiol 44(1):52. https:\/\/doi.org\/10.1007\/s10571-024-01487-0","journal-title":"Cell Mol Neurobiol"},{"key":"6215_CR86","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.1029279","volume":"16","author":"B Han","year":"2022","unstructured":"Han B, Kikuta S, Kamogashira T, Kondo K, Yamasoba T (2022) Sleep deprivation induces delayed regeneration of olfactory sensory neurons following injury. Front Neurosci 16:1029279. https:\/\/doi.org\/10.3389\/fnins.2022.1029279","journal-title":"Front Neurosci"},{"issue":"1","key":"6215_CR87","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35607-w","volume":"8","author":"A Tuerdi","year":"2018","unstructured":"Tuerdi A, Kikuta S, Kinoshita M, Kamogashira T, Kondo K, Iwasaki S, Yamasoba T (2018) Dorsal-zone-specific reduction of sensory neuron density in the olfactory epithelium following long-term exercise or caloric restriction. Sci Rep 8(1):17300. https:\/\/doi.org\/10.1038\/s41598-018-35607-w","journal-title":"Sci Rep"},{"issue":"3","key":"6215_CR88","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1002\/(sici)1096-9861(19990927)412:3<439::aid-cne5>3.0.co;2-h","volume":"412","author":"JE Schwob","year":"1999","unstructured":"Schwob JE, Youngentob SL, Ring G, Iwema CL, Mezza RC (1999) Reinnervation of the rat olfactory bulb after methyl bromide-induced lesion: timing and extent of reinnervation. J Comp Neurol 412(3):439\u2013457. https:\/\/doi.org\/10.1002\/(sici)1096-9861(19990927)412:3%3c439::aid-cne5%3e3.0.co;2-h","journal-title":"J Comp Neurol"},{"issue":"1","key":"6215_CR89","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79249-3","volume":"10","author":"A Tuerdi","year":"2020","unstructured":"Tuerdi A, Kikuta S, Kinoshita M, Kamogashira T, Kondo K, Yamasoba T (2020) Zone-specific damage of the olfactory epithelium under protein restriction. Sci Rep 10(1):22175. https:\/\/doi.org\/10.1038\/s41598-020-79249-3","journal-title":"Sci Rep"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-06215-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-026-06215-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-06215-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:03:15Z","timestamp":1790190195000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-026-06215-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":89,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["6215"],"URL":"https:\/\/doi.org\/10.1007\/s12035-026-06215-x","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"11 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Animal experiments were conducted in accordance with the EC directive 86\/609\/European Economic Community guidelines for animal experiments and permitted by the local government (Th\u00fcringer Landesamt f\u00fcr Lebensmittelsicherheit und Verbraucherschutz).","order":1,"name":"Ethics","label":"Ethics Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"918"}}