{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:56:20Z","timestamp":1790837780332,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12035-026-06231-x","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:30:40Z","timestamp":1790411440000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative Multi-Omics Analysis Suggests a Proteostasis\u2013Translation\u2013Neuroimmune Axis Underlying Moxifloxacin Associated Cognitive Impairment"],"prefix":"10.1007","volume":"63","author":[{"given":"Hangyu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlong","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqia","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexin","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suidong","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"issue":"10","key":"6231_CR1","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1039\/C9MD00120D","volume":"10","author":"TDM Pham","year":"2019","unstructured":"Pham TDM, Ziora ZM, Blaskovich MAT (2019) Quinolone antibiotics. MedChemComm 10(10):1719\u20131739. https:\/\/doi.org\/10.1039\/C9MD00120D","journal-title":"MedChemComm"},{"issue":"3","key":"6231_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2023.106905","volume":"62","author":"SH Choi","year":"2023","unstructured":"Choi SH, Cesar A, Snow TAC, Saleem N, Arulkumaran N, Singer M (2023) Respiratory fluoroquinolone monotherapy vs. \u03b2-lactam plus macrolide combination therapy for hospitalized adults with community-acquired pneumonia: a systematic review and meta-analysis of randomized controlled trials. Int J Antimicrob Agents 62(3):106905. https:\/\/doi.org\/10.1016\/j.ijantimicag.2023.106905","journal-title":"Int J Antimicrob Agents"},{"issue":"5","key":"6231_CR3","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1007\/s00192-021-05013-4","volume":"33","author":"K Yan","year":"2022","unstructured":"Yan K, Zhu M, Jia Y, Wang J, Cai Y (2022) Efficacy and safety of quinolones vs. other antimicrobials for the treatment of uncomplicated urinary tract infections in adults: a systematic review and meta-analysis. Int Urogynecol J 33(5):1103\u20131123. https:\/\/doi.org\/10.1007\/s00192-021-05013-4","journal-title":"Int Urogynecol J"},{"key":"6231_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1435923","volume":"15","author":"WL Xie","year":"2024","unstructured":"Xie WL, Ge ML, Chen D, Chen GQ, Mei YX, Lai YJ (2024) Psychiatric disorders associated with fluoroquinolones: a pharmacovigilance analysis of the FDA adverse event reporting system database. Front Pharmacol 15:1435923. https:\/\/doi.org\/10.3389\/fphar.2024.1435923","journal-title":"Front Pharmacol"},{"key":"6231_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/ph16081105","author":"P Wierzbi\u0144ski","year":"2023","unstructured":"Wierzbi\u0144ski P, Hubska J, Henzler M, Kucharski B, Bie\u015b R, Krzystanek M (2023) Depressive and other adverse CNS effects of fluoroquinolones. Pharmaceuticals (Basel). https:\/\/doi.org\/10.3390\/ph16081105","journal-title":"Pharmaceuticals (Basel)"},{"issue":"11","key":"6231_CR6","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1080\/14740338.2022.2147924","volume":"21","author":"C Bove","year":"2022","unstructured":"Bove C, Baldock RA, Champigneulle O, Martin L, Bennett CL (2022) Fluoroquinolones: old drugs, putative new toxicities. Expert Opin Drug Saf 21(11):1365\u20131378. https:\/\/doi.org\/10.1080\/14740338.2022.2147924","journal-title":"Expert Opin Drug Saf"},{"issue":"5","key":"6231_CR7","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.psym.2011.01.037","volume":"52","author":"H Tasleem","year":"2011","unstructured":"Tasleem H, Viswanathan R (2011) Moxifloxacin-induced delirium with hallucinations. Psychosomatics 52(5):472\u2013474. https:\/\/doi.org\/10.1016\/j.psym.2011.01.037","journal-title":"Psychosomatics"},{"issue":"3","key":"6231_CR8","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.ijtb.2020.05.002","volume":"67","author":"GK Mittal","year":"2020","unstructured":"Mittal GK, Reddy V, Akhtar SM, Kaur H (2020) Moxifloxacin induced encephalopathy in disseminated tuberculosis: a case report. Indian J Tuberc 67(3):423\u2013425. https:\/\/doi.org\/10.1016\/j.ijtb.2020.05.002","journal-title":"Indian J Tuberc"},{"issue":"8","key":"6231_CR9","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfae174","volume":"17","author":"S Liabeuf","year":"2024","unstructured":"Liabeuf S, Hafez G, Pe\u0161i\u0107 V, Spasovski G, Bobot M, Ma\u010diulaitis R, Bumblyte IA, Ferreira AC et al (2024) Drugs with a negative impact on cognitive functions (part 3): antibacterial agents in patients with chronic kidney disease. Clin Kidney J 17(8):sfae174. https:\/\/doi.org\/10.1093\/ckj\/sfae174","journal-title":"Clin Kidney J"},{"issue":"12","key":"6231_CR10","doi-asserted-by":"publisher","first-page":"4372","DOI":"10.1093\/brain\/awaf222","volume":"148","author":"S Jiang","year":"2025","unstructured":"Jiang S, Srikanth M, Serpe R, Yavari S, Gaur P, Collins GA, Soni R, Menon V et al (2025) Early proteasome downregulation and dysfunction drive proteostasis failure in Alzheimer\u2019s disease. Brain 148(12):4372\u20134388. https:\/\/doi.org\/10.1093\/brain\/awaf222","journal-title":"Brain"},{"key":"6231_CR11","doi-asserted-by":"publisher","unstructured":"She LY, Li LY, Tang H, Yu Q, Gao FY, Zeng YQ, Chen LJ, Xiong L (2025) OTUD1 positively regulates microglia neuroinflammation and promotes the pathogenesis of Alzheimer\u2019s disease by deubiquitinating C\/EBP\u03b2. Acta Pharmacol Sin 46(10):2608\u20132621.https:\/\/doi.org\/10.1038\/s41401-025-01566-y","DOI":"10.1038\/s41401-025-01566-y"},{"issue":"8050","key":"6231_CR12","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41586-024-08474-x","volume":"638","author":"MA Wheeler","year":"2025","unstructured":"Wheeler MA, Quintana FJ (2025) The neuroimmune connectome in health and disease. Nature 638(8050):333\u2013342. https:\/\/doi.org\/10.1038\/s41586-024-08474-x","journal-title":"Nature"},{"issue":"7829","key":"6231_CR13","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/s41586-020-2805-8","volume":"586","author":"V Sharma","year":"2020","unstructured":"Sharma V, Sood R, Khlaifia A, Eslamizade MJ, Hung TY, Lou D, Asgarihafshejani A, Lalzar M et al (2020) EIF2\u03b1 controls memory consolidation via excitatory and somatostatin neurons. Nature 586(7829):412\u2013416. https:\/\/doi.org\/10.1038\/s41586-020-2805-8","journal-title":"Nature"},{"issue":"7","key":"6231_CR14","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41580-019-0101-y","volume":"20","author":"MS Hipp","year":"2019","unstructured":"Hipp MS, Kasturi P, Hartl FU (2019) The proteostasis network and its decline in ageing. Nat Rev Mol Cell Biol 20(7):421\u2013435. https:\/\/doi.org\/10.1038\/s41580-019-0101-y","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"6231_CR15","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.apsb.2024.11.020","volume":"15","author":"J Sun","year":"2025","unstructured":"Sun J, Chen F, She L, Zeng Y, Tang H, Ye B, Zheng W, Xiong L et al (2025) YOD1 regulates microglial homeostasis by deubiquitinating MYH9 to promote the pathogenesis of Alzheimer\u2019s disease. Acta Pharm Sin B 15(1):331\u2013348. https:\/\/doi.org\/10.1016\/j.apsb.2024.11.020","journal-title":"Acta Pharm Sin B"},{"key":"6231_CR16","doi-asserted-by":"publisher","unstructured":"Del Giudice G, Serra A, Pavel A, Torres Maia M, Saarim\u00e4ki LA, Fratello M, Federico A, Alenius H et al (2024) A network toxicology approach for mechanistic modelling of nanomaterial hazard and adverse outcomes. Adv Sci (Weinh) 11(32):e2400389. https:\/\/doi.org\/10.1002\/advs.202400389","DOI":"10.1002\/advs.202400389"},{"key":"6231_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.118834","volume":"303","author":"Y Pan","year":"2025","unstructured":"Pan Y, Cai H, Ran Y, Qiu H, Huang Z, Wu D, Zhang W, Zhang N et al (2025) Revealing 1,3-diphenylpropane\u2019s coagulation toxicity via infomaxnet-based network toxicology and molecular simulations. Ecotoxicol Environ Saf 303:118834. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118834","journal-title":"Ecotoxicol Environ Saf"},{"issue":"19","key":"6231_CR18","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1001\/jama.2017.17219","volume":"318","author":"CA Emdin","year":"2017","unstructured":"Emdin CA, Khera AV, Kathiresan S (2017) Mendelian randomization. JAMA 318(19):1925\u20131926. https:\/\/doi.org\/10.1001\/jama.2017.17219","journal-title":"JAMA"},{"key":"6231_CR19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k601","volume":"362","author":"NM Davies","year":"2018","unstructured":"Davies NM, Holmes MV, Davey Smith G (2018) Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ 362:k601. https:\/\/doi.org\/10.1136\/bmj.k601","journal-title":"BMJ"},{"issue":"1","key":"6231_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-024-02947-3","volume":"25","author":"S Ouyang","year":"2024","unstructured":"Ouyang S, Lu P, Li J, Jin H, Wu W, Luo R, Wang B, Huang X et al (2024) Inhaled tea polyphenol-loaded nanoparticles coated with platelet membranes largely attenuate asthmatic inflammation. Respir Res 25(1):311. https:\/\/doi.org\/10.1186\/s12931-024-02947-3","journal-title":"Respir Res"},{"issue":"1","key":"6231_CR21","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0184-x","volume":"12","author":"AG Efthymiou","year":"2017","unstructured":"Efthymiou AG, Goate AM (2017) Late onset Alzheimer\u2019s disease genetics implicates microglial pathways in disease risk. Mol Neurodegener 12(1):43. https:\/\/doi.org\/10.1186\/s13024-017-0184-x","journal-title":"Mol Neurodegener"},{"issue":"4","key":"6231_CR22","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","volume":"164","author":"B De Strooper","year":"2016","unstructured":"De Strooper B, Karran E (2016) The cellular phase of Alzheimer\u2019s disease. Cell 164(4):603\u2013615. https:\/\/doi.org\/10.1016\/j.cell.2015.12.056","journal-title":"Cell"},{"issue":"1","key":"6231_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40208-x","volume":"14","author":"M Askenazi","year":"2023","unstructured":"Askenazi M, Kavanagh T, Pires G, Ueberheide B, Wisniewski T, Drummond E (2023) Compilation of reported protein changes in the brain in Alzheimer\u2019s disease. Nat Commun 14(1):4466. https:\/\/doi.org\/10.1038\/s41467-023-40208-x","journal-title":"Nat Commun"},{"key":"6231_CR24","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1146\/annurev-pathol-020712-163927","volume":"10","author":"HV Vinters","year":"2015","unstructured":"Vinters HV (2015) Emerging concepts in Alzheimer\u2019s disease. Annu Rev Pathol 10:291\u2013319. https:\/\/doi.org\/10.1146\/annurev-pathol-020712-163927","journal-title":"Annu Rev Pathol"},{"key":"6231_CR25","doi-asserted-by":"publisher","unstructured":"Lei M, Xu H, Li Z, Wang Z, O\u2019Malley TT, Zhang D, Walsh DM, Xu P et al (2016) Soluble A\u03b2 oligomers impair hippocampal LTP by disrupting glutamatergic\/GABAergic balance. Neurobiol Dis 85:111\u2013121. https:\/\/doi.org\/10.1016\/j.nbd.2015.10.019","DOI":"10.1016\/j.nbd.2015.10.019"},{"key":"6231_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2025.106971","volume":"212","author":"C Soriano-Herrador","year":"2025","unstructured":"Soriano-Herrador C, Ubeda-Banon I, Villanueva-Anguita P, Saiz-Sanchez D, Astillero-Lopez V, Martinez-Marcos A, Flores-Cuadrado A (2025) The chaperones HSP90AA1, HSP90AB1 and BAG3 are specifically distributed among human hippocampal subfields during different Alzheimer\u2019s disease stages. Neurobiol Dis 212:106971. https:\/\/doi.org\/10.1016\/j.nbd.2025.106971","journal-title":"Neurobiol Dis"},{"key":"6231_CR27","doi-asserted-by":"publisher","unstructured":"Di Lorenzo D, Bisi N, Kaffy J, Ramirez LM, Zweckstetter M, Lequin O, Garfagnini I, Luo J et al (2025) Synthetic chaperone based on Hsp90-Tau interaction inhibits Tau aggregation and rescues physiological Tau-Microtubule interaction. Nat Commun 16(1):8756.https:\/\/doi.org\/10.1038\/s41467-025-63824-1","DOI":"10.1038\/s41467-025-63824-1"},{"issue":"11","key":"6231_CR28","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax6999","volume":"6","author":"S Weickert","year":"2020","unstructured":"Weickert S, Wawrzyniuk M, John LH, R\u00fcdiger SGD, Drescher M (2020) The mechanism of Hsp90-induced oligomerizaton of Tau. Sci Adv 6(11):eaax6999. https:\/\/doi.org\/10.1126\/sciadv.aax6999","journal-title":"Sci Adv"},{"issue":"1","key":"6231_CR29","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.neuron.2008.10.055","volume":"61","author":"M Costa-Mattioli","year":"2009","unstructured":"Costa-Mattioli M, Sossin WS, Klann E, Sonenberg N (2009) Translational control of long-lasting synaptic plasticity and memory. Neuron 61(1):10\u201326. https:\/\/doi.org\/10.1016\/j.neuron.2008.10.055","journal-title":"Neuron"},{"issue":"7432","key":"6231_CR30","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature11628","volume":"493","author":"CG Gkogkas","year":"2013","unstructured":"Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S et al (2013) Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature 493(7432):371\u2013377. https:\/\/doi.org\/10.1038\/nature11628","journal-title":"Nature"},{"issue":"1","key":"6231_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31127-4","volume":"13","author":"Y Chen","year":"2022","unstructured":"Chen Y, Tsai B, Li N, Gao N (2022) Structural remodeling of ribosome associated Hsp40-Hsp70 chaperones during co-translational folding. Nat Commun 13(1):3410. https:\/\/doi.org\/10.1038\/s41467-022-31127-4","journal-title":"Nat Commun"},{"issue":"6","key":"6231_CR32","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/s41580-019-0118-2","volume":"20","author":"CAP Joazeiro","year":"2019","unstructured":"Joazeiro CAP (2019) Mechanisms and functions of ribosome-associated protein quality control. Nat Rev Mol Cell Biol 20(6):368\u2013383. https:\/\/doi.org\/10.1038\/s41580-019-0118-2","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"6231_CR33","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1146\/annurev-immunol-082323-035253","volume":"43","author":"LV Sinclair","year":"2025","unstructured":"Sinclair LV, Cantrell DA (2025) Protein synthesis and metabolism in T cells. Annu Rev Immunol 43(1):343\u2013366. https:\/\/doi.org\/10.1146\/annurev-immunol-082323-035253","journal-title":"Annu Rev Immunol"},{"key":"6231_CR34","doi-asserted-by":"publisher","DOI":"10.1172\/jci132727","author":"L Keane","year":"2021","unstructured":"Keane L, Antignano I, Riechers SP, Zollinger R, Dumas AA, Offermann N, Bernis ME, Russ J et al (2021) mTOR-dependent translation amplifies microglia priming in aging mice. J Clin Invest. https:\/\/doi.org\/10.1172\/jci132727","journal-title":"J Clin Invest"},{"issue":"2","key":"6231_CR35","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.immuni.2025.01.007","volume":"58","author":"RM McManus","year":"2025","unstructured":"McManus RM, Komes MP, Griep A, Santarelli F, Schwartz S, Ram\u00f3n Perea J, Schlachetzki JCM, Bouvier DS et al (2025) NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer\u2019s disease progression. Immunity 58(2):326-343.e311. https:\/\/doi.org\/10.1016\/j.immuni.2025.01.007","journal-title":"Immunity"},{"key":"6231_CR36","doi-asserted-by":"publisher","unstructured":"Zhang K, Chen J, Zhu Z, Hu H, Zhang Q, Jia R, Wang N, Xiang S et al (2025) CD74 blockade disrupts endothelial migrasome signaling to prevent inflammatory macrophage differentiation and inhibit atherosclerotic progression. Adv Sci (Weinh) 12(35):e02838.https:\/\/doi.org\/10.1002\/advs.202502838","DOI":"10.1002\/advs.202502838"},{"key":"6231_CR37","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jot.2024.09.013","volume":"50","author":"P Liao","year":"2025","unstructured":"Liao P, Tong S, Du L, Mei J, Wang B, Lu Y, Yao M, Zhang C et al (2025) Single-cell transcriptomics identifies the common perturbations of monocyte\/macrophage lineage cells in inflammaging of bone marrow. J Orthop Transl 50:85\u201396. https:\/\/doi.org\/10.1016\/j.jot.2024.09.013","journal-title":"J Orthop Transl"},{"issue":"32","key":"6231_CR38","doi-asserted-by":"publisher","first-page":"8471","DOI":"10.1523\/jneurosci.4654-15.2016","volume":"36","author":"GD Manocha","year":"2016","unstructured":"Manocha GD, Floden AM, Rausch K, Kulas JA, McGregor BA, Rojanathammanee L, Puig KR, Puig KL et al (2016) APP regulates microglial phenotype in a mouse model of Alzheimer\u2019s disease. J Neurosci 36(32):8471\u20138486. https:\/\/doi.org\/10.1523\/jneurosci.4654-15.2016","journal-title":"J Neurosci"},{"key":"6231_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2024.109941","volume":"252","author":"RM McManus","year":"2024","unstructured":"McManus RM, Latz E (2024) NLRP3 inflammasome signalling in Alzheimer\u2019s disease. Neuropharmacology 252:109941. https:\/\/doi.org\/10.1016\/j.neuropharm.2024.109941","journal-title":"Neuropharmacology"},{"key":"6231_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2016.00118","volume":"9","author":"WM Snow","year":"2016","unstructured":"Snow WM, Albensi BC (2016) Neuronal gene targets of NF-\u03baB and their dysregulation in Alzheimer\u2019s disease. Front Mol Neurosci 9:118. https:\/\/doi.org\/10.3389\/fnmol.2016.00118","journal-title":"Front Mol Neurosci"},{"issue":"4","key":"6231_CR41","doi-asserted-by":"publisher","first-page":"207","DOI":"10.9740\/mhc.2016.07.207","volume":"6","author":"A Warstler","year":"2016","unstructured":"Warstler A, Bean J (2016) Antimicrobial-induced cognitive side effects. Ment Health Clin 6(4):207\u2013214. https:\/\/doi.org\/10.9740\/mhc.2016.07.207","journal-title":"Ment Health Clin"},{"key":"6231_CR42","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ejps.2018.06.018","volume":"122","author":"N Mihajlica","year":"2018","unstructured":"Mihajlica N, Betsholtz C, Hammarlund-Udenaes M (2018) Pharmacokinetics of pericyte involvement in small-molecular drug transport across the blood-brain barrier. Eur J Pharm Sci 122:77\u201384. https:\/\/doi.org\/10.1016\/j.ejps.2018.06.018","journal-title":"Eur J Pharm Sci"},{"issue":"1","key":"6231_CR43","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12974-019-1538-9","volume":"16","author":"M Zusso","year":"2019","unstructured":"Zusso M, Lunardi V, Franceschini D, Pagetta A, Lo R, Stifani S, Frigo AC, Giusti P et al (2019) Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4\/NF-kB pathway. J Neuroinflammation 16(1):148. https:\/\/doi.org\/10.1186\/s12974-019-1538-9","journal-title":"J Neuroinflammation"},{"issue":"6","key":"6231_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2626-6","volume":"11","author":"JP Br\u00e1s","year":"2020","unstructured":"Br\u00e1s JP, Bravo J, Freitas J, Barbosa MA, Santos SG, Summavielle T, Almeida MI (2020) TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity. Cell Death Dis 11(6):415. https:\/\/doi.org\/10.1038\/s41419-020-2626-6","journal-title":"Cell Death Dis"},{"key":"6231_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2024.105868","volume":"165","author":"TQ Ge","year":"2024","unstructured":"Ge TQ, Guan PP, Wang P (2024) Complement 3a induces the synapse loss via C3aR in mitochondria-dependent NLRP3 activating mechanisms during the development and progression of Alzheimer\u2019s disease. Neurosci Biobehav Rev 165:105868. https:\/\/doi.org\/10.1016\/j.neubiorev.2024.105868","journal-title":"Neurosci Biobehav Rev"},{"issue":"7638","key":"6231_CR46","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature21029","volume":"541","author":"SA Liddelow","year":"2017","unstructured":"Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, M\u00fcnch AE, et al. (2017) Neurotoxic reactive astrocytes are induced by activated microglia. Nature 541(7638):481\u2013487. https:\/\/doi.org\/10.1038\/nature21029","journal-title":"Nature"},{"issue":"9","key":"6231_CR47","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1002\/glia.24383","volume":"71","author":"D Kleidonas","year":"2023","unstructured":"Kleidonas D, Kirsch M, Andrieux G, Pfeifer D, Boerries M, Vlachos A (2023) Microglia modulate TNF\u03b1-mediated synaptic plasticity. Glia 71(9):2117\u20132136. https:\/\/doi.org\/10.1002\/glia.24383","journal-title":"Glia"},{"key":"6231_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.113879","volume":"428","author":"D Liu","year":"2022","unstructured":"Liu D, Lv F, Min S, Yang Y, Chen L (2022) Inhibition of NLRP3 inflammasome-mediated neuroinflammation alleviates electroconvulsive shock-induced memory impairment via regulation of hippocampal synaptic plasticity in depressive rats. Behav Brain Res 428:113879. https:\/\/doi.org\/10.1016\/j.bbr.2022.113879","journal-title":"Behav Brain Res"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-06231-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-026-06231-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-026-06231-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:08:03Z","timestamp":1790834883000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-026-06231-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["6231"],"URL":"https:\/\/doi.org\/10.1007\/s12035-026-06231-x","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"13 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original version of this paper was updated to delete \"College of Medical Technology\" in Affiliation 1.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":1,"name":"Ethics","label":"Ethics Approval and Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Clinical Trial Number","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"929"}}