{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:23:33Z","timestamp":1792783413736,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T00:00:00Z","timestamp":1455148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001518","name":"Maurice & Phyllis Paykel Trust","doi-asserted-by":"crossref","award":["110443.01.Q.PZ"],"award-info":[{"award-number":["110443.01.Q.PZ"]}],"id":[{"id":"10.13039\/501100001518","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Infection Research Group"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Biosci"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1007\/s12038-016-9598-9","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T01:40:48Z","timestamp":1455154848000},"page":"87-95","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Cystathionine-\u03b3-lyase gene silencing with siRNA in monocytes\/macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse"],"prefix":"10.1007","volume":"41","author":[{"given":"A","family":"Badiei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S T","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R R","family":"Gaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,11]]},"reference":[{"key":"9598_CR1","doi-asserted-by":"crossref","first-page":"G712","DOI":"10.1152\/ajpgi.00044.2013","volume":"305","author":"AD Ang","year":"2013","unstructured":"Ang AD, Rivers-Auty J, Hegde A, Ishii I and Bhatia M 2013 The effect of CSE gene deletion in caerulein-induced acute pancreatitis in the mouse. Am. J. Physiol. Gastrointest. Liver Physiol. 305 G712\u2013G721","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"9598_CR2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/CCM.0b013e3181c0df00","volume":"38","author":"SF Ang","year":"2010","unstructured":"Ang SF, Moochhala SM and Bhatia M 2010 Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis. Crit. Care Med. 38 619\u2013628","journal-title":"Crit. Care Med."},{"key":"9598_CR3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1155\/2014\/848570","volume":"2014","author":"A Badiei","year":"2014","unstructured":"Badiei A, Muniraj N, Chambers S and Bhatia M 2014 Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity by downregulation of NF-\u03baB and MAP kinase activity in LPS-activated RAW 264.7 cells. BioMed Res. Int. 2014 7","journal-title":"BioMed Res. Int."},{"key":"9598_CR4","doi-asserted-by":"crossref","first-page":"7845","DOI":"10.1007\/s00253-013-5080-x","volume":"97","author":"A Badiei","year":"2013","unstructured":"Badiei A, Rivers-Auty J, Ang AD and Bhatia M 2013 Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity of LPS-activated RAW264.7 cells. Appl. Microbiol. Biotechnol. 97 7845\u20137852","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"9598_CR5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/sj.bjp.0706186","volume":"145","author":"M Bhatia","year":"2005","unstructured":"Bhatia M, Sidhapuriwala J, Moochhala SM and Moore PK 2005a Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat. Br. J. Pharmacol. 145 141\u2013144","journal-title":"Br. J. Pharmacol."},{"key":"9598_CR6","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1582-4934.2007.00131.x","volume":"12","author":"M Bhatia","year":"2008","unstructured":"Bhatia M, Sidhapuriwala JN, Ng SW, Tamizhselvi R and Moochhala SM 2008 Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis. J. Cell. Mol. Med. 12 580\u2013590","journal-title":"J. Cell. Mol. Med."},{"key":"9598_CR7","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1096\/fj.04-3023fje","volume":"19","author":"M Bhatia","year":"2005","unstructured":"Bhatia M, Wong FL, Fu D, Lau HY, Moochhala SM and Moore PK 2005b Role of hydrogen sulfide in acute pancreatitis and associated lung injury. FASEB J. 19 623\u2013625","journal-title":"FASEB J."},{"key":"9598_CR8","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1016\/S0021-9258(19)85725-3","volume":"255","author":"G Burnett","year":"1980","unstructured":"Burnett G, Marcotte P and Walsh C 1980 Mechanism-based inactivation of pig heart L-alanine transaminase by L-propargylglycine. Half-site reactivity. J. Biol. Chem. 255 3487\u20133491","journal-title":"J. Biol. Chem."},{"key":"9598_CR9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/00024382-200115040-00005","volume":"15","author":"DR Call","year":"2001","unstructured":"Call DR, Nemzek JA, Ebong SJ, Bolgos GR, Newcomb DE, Wollenberg GK and Remick DG 2001 Differential local and systemic regulation of the murine chemokines KC and MIP2. Shock 15 278\u2013284","journal-title":"Shock"},{"key":"9598_CR10","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature01326","volume":"420","author":"J Cohen","year":"2002","unstructured":"Cohen J 2002 The immunopathogenesis of sepsis. Nature 420 885\u2013891","journal-title":"Nature"},{"key":"9598_CR11","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/sj.bjp.0706367","volume":"146","author":"M Collin","year":"2005","unstructured":"Collin M, Anuar FB, Murch O, Bhatia M, Moore PK and Thiemermann C 2005 Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. Br. J. Pharmacol. 146 498\u2013505","journal-title":"Br. J. Pharmacol."},{"key":"9598_CR12","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1182\/blood.V74.5.1704.1704","volume":"74","author":"CE Hack","year":"1989","unstructured":"Hack CE, De Groot ER, Felt-Bersma RJ, Nuijens JH, Strack Van Schijndel RJ, Eerenberg-Belmer AJ, Thijs LG and Aarden LA 1989 Increased plasma levels of interleukin-6 in sepsis. Blood 74 1704\u20131710","journal-title":"Blood"},{"key":"9598_CR13","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","volume":"19","author":"L Li","year":"2005","unstructured":"Li L, Bhatia M, Zhu YZ, Zhu YC, Ramnath RD, Wang ZJ, Anuar FB, Whiteman M, et al. 2005 Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse. FASEB J. 19 1196\u20131198","journal-title":"FASEB J."},{"key":"9598_CR14","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/ijcp.12382","volume":"68","author":"S Lv","year":"2014","unstructured":"Lv S, Han M, Yi R, Kwon S, Dai C and Wang R 2014 Anti-TNF-alpha therapy for patients with sepsis: a systematic meta-analysis. Int. J. Clin. Pract. 68 520\u2013528","journal-title":"Int. J. Clin. Pract."},{"key":"9598_CR15","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1021\/bi00659a021","volume":"15","author":"P Marcotte","year":"1976","unstructured":"Marcotte P and Walsh C 1976 Vinylglycine and proparglyglycine: complementary suicide substrates for L-amino acid oxidase and D-amino acid oxidase. Biochemistry. 15 3070\u20133076","journal-title":"Biochemistry"},{"key":"9598_CR16","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.4049\/jimmunol.160.6.2959","volume":"160","author":"AB Nathens","year":"1998","unstructured":"Nathens AB, Bitar R, Watson RW, Issekutz TB, Marshall JC, Dackiw AP and Rotstein OD 1998 Thiol-mediated regulation of ICAM-1 expression in endotoxin-induced acute lung injury. J. Immunol. 160 2959\u20132966","journal-title":"J. Immunol."},{"key":"9598_CR17","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.intimp.2008.01.033","volume":"8","author":"RD Ramnath","year":"2008","unstructured":"Ramnath RD, Ng SW, Guglielmotti A and Bhatia M 2008 Role of MCP-1 in endotoxemia and sepsis. Int. Immunopharmacol. 8 810\u2013818","journal-title":"Int. Immunopharmacol."},{"key":"9598_CR18","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.2353\/ajpath.2007.060872","volume":"170","author":"DG Remick","year":"2007","unstructured":"Remick DG 2007 Pathophysiology of sepsis. Am. J. Pathol. 170 1435\u20131444","journal-title":"Am. J. Pathol."},{"key":"9598_CR19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1517\/14728222.2012.673591","volume":"16","author":"JR Rivers","year":"2012","unstructured":"Rivers JR, Badiei A and Bhatia M 2012 Hydrogen sulfide as a therapeutic target for inflammation. Expert Opin. Ther. Targets 16 439\u2013449","journal-title":"Expert Opin. Ther. Targets"},{"key":"9598_CR20","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/jama.1995.03530010072037","volume":"274","author":"AJ Rosenbloom","year":"1995","unstructured":"Rosenbloom AJ, Pinsky MR, Bryant JL, Shin A, Tran T and Whiteside T 1995 Leukocyte activation in the peripheral blood of patients with cirrhosis of the liver and SIRS. Correlation with serum interleukin-6 levels and organ dysfunction. JAMA 274 58\u201365","journal-title":"JAMA"},{"key":"9598_CR21","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/0090-1229(92)90036-N","volume":"62","author":"CE Spooner","year":"1992","unstructured":"Spooner CE, Markowitz NP and Saravolatz LD 1992 The role of tumor necrosis factor in sepsis. Clin. Immunol. Immunopathol. 62 S11\u2013S17","journal-title":"Clin. Immunol. Immunopathol."},{"key":"9598_CR22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/01.shk.0000145936.31967.d7","volume":"23","author":"H Tsujimoto","year":"2005","unstructured":"Tsujimoto H, Ono S, Majima T, Kawarabayashi N, Takayama E, Kinoshita M, Seki S, Hiraide H, et al. 2005 Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis. Shock 23 39\u201344","journal-title":"Shock"},{"key":"9598_CR23","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.4049\/jimmunol.181.6.4320","volume":"181","author":"H Zhang","year":"2008","unstructured":"Zhang H, Moochhala SM and Bhatia M 2008 Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis. J. Immunol. 181 4320\u20134331","journal-title":"J. Immunol."},{"key":"9598_CR24","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1189\/jlb.0407237","volume":"82","author":"H Zhang","year":"2007","unstructured":"Zhang H, Zhi L, Moochhala SM, Moore PK and Bhatia M 2007 Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis. J. Leukoc. Biol. 82 894\u2013905","journal-title":"J. Leukoc. Biol."},{"key":"9598_CR25","doi-asserted-by":"crossref","first-page":"L1193","DOI":"10.1152\/ajplung.00489.2005","volume":"290","author":"H Zhang","year":"2006","unstructured":"Zhang H, Zhi L, Moore PK and Bhatia M 2006 Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse. Am. J. Physiol. Lung Cell. Mol. Physiol. 290 L1193\u2013L1201","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"9598_CR26","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2119\/molmed.2010.00027","volume":"16","author":"J Zhang","year":"2010","unstructured":"Zhang J, Sio SW, Moochhala S and Bhatia M 2010 Role of hydrogen sulfide in severe burn injury-induced inflammation in mice. Mol. Med. 16 417\u2013424","journal-title":"Mol. Med."}],"container-title":["Journal of Biosciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12038-016-9598-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12038-016-9598-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12038-016-9598-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T16:51:22Z","timestamp":1692204682000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12038-016-9598-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,11]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["9598"],"URL":"https:\/\/doi.org\/10.1007\/s12038-016-9598-9","relation":{},"ISSN":["0250-5991","0973-7138"],"issn-type":[{"value":"0250-5991","type":"print"},{"value":"0973-7138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,11]]}}}