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However, there are elderly patients in which surgical treatment may be deemed extremely high risk or futile. Endovascular treatment approaches have been applied to a small number of these patients and data are limited to case reports and small series. The application of endovascular therapies to ascending aorta is currently limited by anatomical and technical challenges posed by the dynamic motion of the ascending aorta and the proximity of vital structures to intended landing zones (aortic valve, coronary arteries, and supra-aortic branches) and lack of specially designed endografts to address these issues. While thoracic endovascular aortic repair (TEVAR) has replaced open aortic repair for a suitable lesion in distal aortic dissection, some selected patients with type A aortic dissection at high surgical may be candidates. Hence, there is potential because, in proximal (Stanford type A) dissections, 10\u201330% of patients are not accepted for surgery, and 30\u201350% are technically amenable for TEVAR. Recent experience has shown that carefully selected patients with favorable anatomical characteristics may be subject to endovascular stent-graft treatment as a last resort with mixed results. Technical improvement is necessary to offer. satisfactory endovascular options in non-surgical candidates.<\/jats:p>","DOI":"10.1007\/s12055-021-01281-3","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T07:02:38Z","timestamp":1639378958000},"page":"183-192","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Alternative management of proximal aortic dissection: concept and application"],"prefix":"10.1007","volume":"38","author":[{"given":"Xun","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Mitsis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mozalbat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph A.","family":"Nienaber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"1281_CR1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jtcvs.2004.09.005","volume":"129","author":"S Trimarchi","year":"2005","unstructured":"Trimarchi S, Nienaber CA, Rampoldi V, et al. 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