{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:30:23Z","timestamp":1765279823412},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s12070-014-0710-x","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T17:23:23Z","timestamp":1392657803000},"page":"302-308","source":"Crossref","is-referenced-by-count":4,"title":["Urinary Neopterin Levels in Patients with Thyroid Cancer"],"prefix":"10.1007","volume":"66","author":[{"given":"Serap Soytac","family":"Inancli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sedat","family":"Caner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fevzi","family":"Balkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas Ali","family":"Tam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulnur","family":"Guler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyhan","family":"Ersoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bekir","family":"Cakir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"issue":"5","key":"710_CR1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3322\/caac.20073","volume":"60","author":"A Jemal","year":"2010","unstructured":"Jemal A, Siegel R, Xu J et al (2010) Cancer statistics 2010. CA Cancer J Clin 60(5):277\u2013300","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"710_CR2","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1007\/s00268-007-9035-1","volume":"31","author":"Y Ito","year":"2007","unstructured":"Ito Y, Hirokawa M, Jikuzono T, Higashiyama T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K, Miyauchi A (2007) Extranodal tumor extension to adjacent organs predicts a worse cause-specific survival in patients with papillary thyroid carcinoma. World J Surg 31(6):1194\u20131201","journal-title":"World J Surg"},{"issue":"1\u20132","key":"710_CR3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.cca.2010.09.015","volume":"412","author":"S Gamagedara","year":"2011","unstructured":"Gamagedara S, Gibbons S, Ma Y (2011) Investigation of urinary pteridine levels as potential biomarkers for noninvasive diagnosis of cancer. Clin Chim Acta 412(1\u20132):120\u2013128","journal-title":"Clin Chim Acta"},{"issue":"1","key":"710_CR4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.canlet.2009.05.008","volume":"287","author":"R Sucher","year":"2010","unstructured":"Sucher R, Schroecksnadel K, Weiss G, Margreiter R, Fuchs D, Brandacher G (2010) Neopterin, a prognostic marker in human malignancies. Cancer Lett 287(1):13\u201322","journal-title":"Cancer Lett"},{"key":"710_CR5","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1084\/jem.160.1.310","volume":"160","author":"C Huber","year":"1984","unstructured":"Huber C, Batchelor JR, Fuchs D, Hausen A, Lang A, Niederwieser D, Reibnegger G, Swetly P, Troppmair J, Wachter H (1984) Immune response associated production of neopterin. Release from macrophages primarily under the control of interferon \u03b3. J Exp Med 160:310\u2013316","journal-title":"J Exp Med"},{"issue":"2","key":"710_CR6","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.clinbiochem.2004.11.002","volume":"38","author":"RA Mahmoud","year":"2005","unstructured":"Mahmoud RA, El-Gendi HI, Ahmed HH (2005) Serum neopterin, tumor necrosis factor-alpha and soluble tumor necrosis factor receptor II (p75) levels and disease activity in Egyptian female patients with systemic lupus erythematosus. Clin Biochem 38(2):134\u2013141","journal-title":"Clin Biochem"},{"issue":"1","key":"710_CR7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10067-011-1767-5","volume":"31","author":"Y Ozkan","year":"2011","unstructured":"Ozkan Y, Mete G, Sepici-Dincel A, Sepici V, Simsek B (2011) Tryptophan degradation and neopterin levels in treated rheumatoid arthritis patients. Clin Rheumatol 31(1):29\u201334. doi: 10.1007\/s10067-011-1767-5","journal-title":"Clin Rheumatol"},{"key":"710_CR8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0020-7292(95)80010-7","volume":"51","author":"IS Park","year":"1995","unstructured":"Park IS, Lee YS, Kim JC, Hwang SG (1995) Serum neopterin levels in ovarian tumors. Int J Gynaecol Obstet 51:229\u2013234","journal-title":"Int J Gynaecol Obstet"},{"key":"710_CR9","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1200\/JCO.1998.16.5.1861","volume":"16","author":"AG Zeimet","year":"1998","unstructured":"Zeimet AG, Widschwendter M, Knabbe C et al (1998) Ascitic interleukin-12 is an independent prognostic factor in ovarian cancer. J Clin Oncol 16:1861\u20131868","journal-title":"J Clin Oncol"},{"key":"710_CR10","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1093\/clinchem\/45.11.1998","volume":"45","author":"C Murr","year":"1999","unstructured":"Murr C, Bergant A, Widschwendter M et al (1999) Neopterin is an independent prognostic variable in females with breast cancer. Clin Chem 45:1998\u20132004","journal-title":"Clin Chem"},{"key":"710_CR11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0009-8981(81)90117-0","volume":"117","author":"A Hausen","year":"1981","unstructured":"Hausen A, Fuchs D, Grunewald K et al (1981) Urinary neopterine as marker for haematological neoplasias. Clin Chim Acta 117:297\u2013305","journal-title":"Clin Chim Acta"},{"key":"710_CR12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1177\/172460080602100309","volume":"21","author":"B Melichar","year":"2006","unstructured":"Melichar B, Solichova D, Melicharova K (2006) Urinary neopterin in patients with advanced colorectal carcinoma. Int J Biol Markers 21:190\u2013198","journal-title":"Int J Biol Markers"},{"key":"710_CR13","first-page":"260","volume":"53","author":"G Weiss","year":"1993","unstructured":"Weiss G, Kronberger P, Conrad F, Bodner E, Wachter H, Reibnegger G (1993) Neopterin and prognosis in patients with adenocarcinoma of the colon. Cancer Res 53:260\u2013265","journal-title":"Cancer Res"},{"issue":"6","key":"710_CR14","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3109\/08941930903410783","volume":"22","author":"B Unal","year":"2009","unstructured":"Unal B, Kocer B, Altun B, Surmeli S, Aksaray S, Balci M, Ozlu B, Cengiz O (2009) Serum neopterin as a prognostic indicator in patients with gastric carcinoma. J Invest Surg 22(6):419\u2013425","journal-title":"J Invest Surg"},{"issue":"11","key":"710_CR15","first-page":"831","volume":"33","author":"P Kronberger","year":"1995","unstructured":"Kronberger P, Weiss G, Tschmelitsch J, Fuchs D, Salzer GM, Wachter H, Reibnegger G (1995) Predictive value of urinary neopterin in patients with lung cancer. Eur J Clin Chem Clin Biochem 33(11):831\u2013837","journal-title":"Eur J Clin Chem Clin Biochem"},{"issue":"4\u20135","key":"710_CR16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/bio.852","volume":"20","author":"B Melichar","year":"2005","unstructured":"Melichar B, Solichov\u00e1 D, Svobodov\u00e1 I, Melicharov\u00e1 K (2005) Neopterin in renal cell carcinoma: inhalational administration of interleukin-2 is not accompanied by a rise of urinary neopterin. Luminescence 20(4\u20135):311","journal-title":"Luminescence"},{"issue":"2","key":"710_CR17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF03345704","volume":"32","author":"TT Sahin","year":"2009","unstructured":"Sahin TT, Yuksel O, Girgin G, Sipahi H, Dikmen K, Azili C, Taneri F, Baydar T (2009) Is neopterin level a predictive and differential biomarker in patients with thyroid disorders? Endocrinol Invest 32(2):147\u2013149","journal-title":"Endocrinol Invest"},{"issue":"4","key":"710_CR18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s12032-008-9054-2","volume":"25","author":"Y Yildirim","year":"2008","unstructured":"Yildirim Y, Gunel N, Coskun U, Pasaoglu H, Aslan S, Cetin A (2008) Serum neopterin levels in patients with breast cancer. Med Oncol 25(4):403\u2013407","journal-title":"Med Oncol"},{"key":"710_CR19","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/0959-8049(93)90539-R","volume":"29A","author":"C Marth","year":"1993","unstructured":"Marth C, Weger A, Muller-Holzner E et al (1993) The prognostic value of nuclear roundness and neopterin in ovarian cancer. Eur J Cancer 29A:1863\u20131868","journal-title":"Eur J Cancer"},{"key":"710_CR20","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1525-1438.2006.00294.x","volume":"16","author":"B Melichar","year":"2006","unstructured":"Melichar B, Solichova D, Freedman RS (2006) Neopterin as an indicator of immune activation and prognosis in patients with gynecological malignancies. Int J Gynecol Cancer 16:240\u2013252","journal-title":"Int J Gynecol Cancer"},{"key":"710_CR21","first-page":"950","volume":"46","author":"GJ Reibnegger","year":"1986","unstructured":"Reibnegger GJ, Bichler AH, Dapunt O et al (1986) Neopterin as a prognostic indicator in patients with carcinoma of the uterine cervix. Cancer Res 46:950\u2013955","journal-title":"Cancer Res"},{"key":"710_CR22","first-page":"4977","volume":"47","author":"G Reibnegger","year":"1987","unstructured":"Reibnegger G, Hetzel H, Fuchs D et al (1987) Clinical significance of neopterin for prognosis and follow-up in ovarian cancer. Cancer Res 47:4977\u20134981","journal-title":"Cancer Res"},{"issue":"4","key":"710_CR23","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1055\/s-0029-1211240","volume":"101","author":"R Wagner","year":"1993","unstructured":"Wagner R, Hayatghebi S, Rosenkranz M, Reinwein D (1993) Increased serum neopterin levels in patients with Graves\u2019 disease. Exp Clin Endocrinol 101(4):249\u2013254","journal-title":"Exp Clin Endocrinol"},{"issue":"2","key":"710_CR24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1055\/s-0029-1211433","volume":"104","author":"A Schomburg","year":"1996","unstructured":"Schomburg A, Gr\u00fcnwald F, Schultes B, Hotze A, Bender H, Biersack HJ (1996) Are serum neopterin concentrations superior to other parameters in the differential diagnosis and prognostic assessment of Graves\u2019 disease? Exp Clin Endocrinol Diabetes 104(2):123\u2013129","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"12","key":"710_CR25","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s00262-010-0907-0","volume":"59","author":"AG Zeimet","year":"2010","unstructured":"Zeimet AG, Reimer D, Schwentner L, Fuchs D, Wolf D, Fuith LC, Fiegl H, Doppler W, Concin N, Daxenbichler G, Marth C (2010) Urinary neopterin does not reflect the local antitumor immune milieu in ovarian cancer. Cancer Immunol Immunother 59(12):1813\u20131823","journal-title":"Cancer Immunol Immunother"},{"key":"710_CR26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1023\/A:1015587423262","volume":"19","author":"C Brigati","year":"2002","unstructured":"Brigati C, Noonan DM, Albini A, Libby A, Benelli R (2002) Tumors and inflammatory infiltrates: friends or foes? Clin Exp Metastasis 19:247\u2013258","journal-title":"Clin Exp Metastasis"},{"key":"710_CR27","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","volume":"420","author":"LM Coussens","year":"2002","unstructured":"Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860\u2013867","journal-title":"Nature"},{"key":"710_CR28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nrc1782","volume":"6","author":"KE deVisser","year":"2006","unstructured":"deVisser KE, Eichten A, Coussens LM (2006) Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6:24\u201337","journal-title":"Nat Rev Cancer"},{"key":"710_CR29","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1089\/thy.2006.0306","volume":"17","author":"C Ugolini","year":"2007","unstructured":"Ugolini C, Basolo F, Proietti A et al (2007) Lymphocyte and immature dendritic cell infiltrates in differentiated, poorly differentiated and undifferentiated thyroid carcinoma. Thyroid 17:389\u2013393","journal-title":"Thyroid"},{"key":"710_CR30","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1038\/sj.onc.1206759","volume":"22","author":"JP Russel","year":"2003","unstructured":"Russel JP, Shinoara S, Melillo RM (2003) Tyrosine kinase oncoprotein, RET\/PTC3, indices the secretion of myeloid growth and chemotactic factors. Oncogene 22:4569\u20134577","journal-title":"Oncogene"},{"issue":"5","key":"710_CR31","first-page":"418","volume":"97","author":"Z Kondera-Anasz","year":"1997","unstructured":"Kondera-Anasz Z, Mertas A, Jochemczyk J, Starzewski J (1997) Level of neopterin in blood serum in selected thyroid diseases. Pol Arch Med Wewn 97(5):418\u2013425","journal-title":"Pol Arch Med Wewn"},{"issue":"5","key":"710_CR32","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2265.1992.tb02352.x","volume":"37","author":"S Mariotti","year":"1992","unstructured":"Mariotti S, Caturegli P, Barbesino G (1992) Thyroid function and thyroid autoimmunity independently modulate serum concentration of soluble interleukin 2 (IL-2) receptor (sIL-2R) in thyroid diseases. Clin Endocrinol (Oxf) 37(5):415\u2013422","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"710_CR33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-2710.2004.00547.x","volume":"29","author":"K Zwirska-Korczala","year":"2004","unstructured":"Zwirska-Korczala K, Berdowska A, Jochem J (2004) Influence of thyroxine on serum soluble interleukin-2 receptor alpha levels in thyroid disorders. Clin Pharm Ther 29(2):151\u2013156","journal-title":"Clin Pharm Ther"},{"issue":"2","key":"710_CR34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1530\/eje.1.01951","volume":"153","author":"JI Botella-Carretero","year":"2005","unstructured":"Botella-Carretero JI, Prados A, Manzano L et al (2005) The effects of thyroid hormones on circulating markers of cell-mediated immune response, as studied in patients with differentiated thyroid carcinoma before and during thyroxine withdrawal. Eur J Endocrinol 153(2):223\u2013230","journal-title":"Eur J Endocrinol"},{"key":"710_CR35","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1365-2249.1992.tb06485.x","volume":"88","author":"B Hofmann","year":"1992","unstructured":"Hofmann B, Bass H, Nishanian P, Faisal M, Figlin RA, Sarna GP, Fahey JL (1992) Verent lymphoid cell populations produce varied levels of neopterin, beta 2-microglobulin and soluble IL-2 receptor when stimulated with IL-2, interferon-\u03b3 or tumour necrosis factor-alpha. Clin Exp Immunol 88:548\u2013554","journal-title":"Clin Exp Immunol"},{"key":"710_CR36","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","volume":"54","author":"A Mantovani","year":"2008","unstructured":"Mantovani A, Allavena P, Sica A et al (2008) Cancer-related inflammation. Nature 54:436\u2013444","journal-title":"Nature"},{"key":"710_CR37","doi-asserted-by":"crossref","first-page":"14825","DOI":"10.1073\/pnas.0503039102","volume":"102","author":"MG Borrello","year":"2005","unstructured":"Borrello MG, Alberti L, Fischer A et al (2005) Induction of a proinflammatory program in normal human thyrocytes by the RET\/PTC1 oncogene. Proc Natl Acad Sci USA 102:14825\u201314830","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"710_CR38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.imlet.2009.02.011","volume":"123","author":"KS Siveen","year":"2009","unstructured":"Siveen KS, Kuttan G (2009) Role of macrophages in tumour progression. Immunol Lett 123(2):97\u2013102","journal-title":"Immunol Lett"}],"container-title":["Indian Journal of Otolaryngology and Head & Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12070-014-0710-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12070-014-0710-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12070-014-0710-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T12:41:11Z","timestamp":1597495271000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12070-014-0710-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,18]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["710"],"URL":"https:\/\/doi.org\/10.1007\/s12070-014-0710-x","relation":{},"ISSN":["2231-3796","0973-7707"],"issn-type":[{"value":"2231-3796","type":"print"},{"value":"0973-7707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,18]]}}}