{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T20:52:53Z","timestamp":1776372773878,"version":"3.51.2"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"S3","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s12070-021-02943-9","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T12:46:10Z","timestamp":1635165970000},"page":"5604-5610","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Haematologic Markers and Tonsil-to-Body Weight Ratio to Assist Adenotonsillar Hypertrophy Diagnosis"],"prefix":"10.1007","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4392-0793","authenticated-orcid":false,"given":"Konstantinos","family":"Kourelis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Marazioti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodoros","family":"Kourelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios T.","family":"Stathopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"issue":"Suppl 1","key":"2943_CR1","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1016\/j.ijporl.2003.08.018","volume":"67","author":"P Brandtzaeg","year":"2003","unstructured":"Brandtzaeg P (2003) Immunology of tonsils and adenoids: everything the ENT surgeon needs to know. Int J Pediatr Otorhinolaryngol 67(Suppl 1):S69-76","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"6","key":"2943_CR2","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.otohns.2006.02.033","volume":"134","author":"SE Brietzke","year":"2006","unstructured":"Brietzke SE, Gallagher D (2006) The effectiveness of tonsillectomy and adenoidectomy in the treatment of pediatric obstructive sleep apnea\/hypopnea syndrome: a meta-analysis. Otolaryngol Head Neck Surg 134(6):979\u2013984. https:\/\/doi.org\/10.1016\/j.otohns.2006.02.033","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"2","key":"2943_CR3","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1513\/pats.200708-135MG","volume":"5","author":"JC Lumeng","year":"2008","unstructured":"Lumeng JC, Chervin RD (2008) Epidemiology of pediatric obstructive sleep apnea. Proc Am Thorac Soc 5(2):242\u2013252. https:\/\/doi.org\/10.1513\/pats.200708-135MG","journal-title":"Proc Am Thorac Soc"},{"issue":"3","key":"2943_CR4","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1542\/peds.2012-1671","volume":"130","author":"CL Marcus","year":"2012","unstructured":"Marcus CL, Brooks LJ, Draper KA, Gozal D, Halbower AC, Jones J, Schechter MS, Sheldon SH, Spruyt K, Ward SD, Lehmann C, Shiffman RN (2012) Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics 130(3):576\u2013584. https:\/\/doi.org\/10.1542\/peds.2012-1671","journal-title":"Pediatrics"},{"issue":"12","key":"2943_CR5","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1164\/rccm.201011-1783OC","volume":"183","author":"P Brandtzaeg","year":"2011","unstructured":"Brandtzaeg P (2011) Potential of nasopharynx-associated lymphoid tissue for vaccine responses in the airways. Am J Respir Crit Care Med 183(12):1595\u20131604. https:\/\/doi.org\/10.1164\/rccm.201011-1783OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"2943_CR6","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1203\/PDR.0b013e3181b453e3","volume":"66","author":"J Kim","year":"2009","unstructured":"Kim J, Bhattacharjee R, Dayyat E, Snow AB, Kheirandish-Gozal L, Goldman JL, Li RC, Serpero LD, Clair HB, Gozal D (2009) Increased cellular proliferation and inflammatory cytokines in tonsils derived from children with obstructive sleep apnea. Pediatr Res 66(4):423\u2013428. https:\/\/doi.org\/10.1203\/PDR.0b013e3181b453e3","journal-title":"Pediatr Res"},{"key":"2943_CR7","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.ijporl.2018.03.011","volume":"108","author":"E Esteller","year":"2018","unstructured":"Esteller E, Villatoro JC, Aguero A, Lopez R, Matino E, Argemi J, Girabent-Farres M (2018) Obstructive sleep apnea syndrome and growth failure. Int J Pediatr Otorhinolaryngol 108:214\u2013218. https:\/\/doi.org\/10.1016\/j.ijporl.2018.03.011","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"10","key":"2943_CR8","doi-asserted-by":"publisher","first-page":"e78666","DOI":"10.1371\/journal.pone.0078666","volume":"8","author":"KT Kang","year":"2013","unstructured":"Kang KT, Chou CH, Weng WC, Lee PL, Hsu WC (2013) Associations between adenotonsillar hypertrophy, age, and obesity in children with obstructive sleep apnea. PLoS ONE 8(10):e78666. https:\/\/doi.org\/10.1371\/journal.pone.0078666","journal-title":"PLoS ONE"},{"issue":"3","key":"2943_CR9","doi-asserted-by":"publisher","first-page":"e213","DOI":"10.1097\/scs.0000000000001437","volume":"26","author":"G Simsek","year":"2015","unstructured":"Simsek G, Karacayli C, Ozel A, Arslan B, Muluk NB, Kilic R (2015) Blood parameters as indicators of upper airway obstruction in children with adenoid or adenotonsillar hypertrophy. J Craniofac Surg 26(3):e213-216. https:\/\/doi.org\/10.1097\/scs.0000000000001437","journal-title":"J Craniofac Surg"},{"issue":"1","key":"2943_CR10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/s1389-9457(99)00009-x","volume":"1","author":"RD Chervin","year":"2000","unstructured":"Chervin RD, Hedger K, Dillon JE, Pituch KJ (2000) Pediatric sleep questionnaire (PSQ): validity and reliability of scales for sleep-disordered breathing, snoring, sleepiness, and behavioral problems. Sleep Med 1(1):21\u201332. https:\/\/doi.org\/10.1016\/s1389-9457(99)00009-x","journal-title":"Sleep Med"},{"issue":"4","key":"2943_CR11","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1001\/archotol.1970.04310040005002","volume":"92","author":"J Jerger","year":"1970","unstructured":"Jerger J (1970) Clinical experience with impedance audiometry. Arch Otolaryngol 92(4):311\u2013324","journal-title":"Arch Otolaryngol"},{"issue":"2","key":"2943_CR12","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3758\/BF03193146","volume":"39","author":"F Faul","year":"2007","unstructured":"Faul F, Erdfelder E, Lang AG, Buchner A (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39(2):175\u2013191","journal-title":"Behav Res Methods"},{"issue":"7","key":"2943_CR13","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.ijporl.2009.04.003","volume":"73","author":"DM Don","year":"2009","unstructured":"Don DM, Geller KA, Koempel JA, Ward SD (2009) Age specific differences in pediatric obstructive sleep apnea. Int J Pediatr Otorhinolaryngol 73(7):1025\u20131028. https:\/\/doi.org\/10.1016\/j.ijporl.2009.04.003","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"1","key":"2943_CR14","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1378\/chest.08-2568","volume":"136","author":"E Dayyat","year":"2009","unstructured":"Dayyat E, Kheirandish-Gozal L, Sans Capdevila O, Maarafeya MMA, Gozal D (2009) Obstructive sleep apnea in children: relative contributions of body mass index and adenotonsillar hypertrophy. Chest 136(1):137\u2013144. https:\/\/doi.org\/10.1378\/chest.08-2568","journal-title":"Chest"},{"issue":"4","key":"2943_CR15","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/S0022-3476(98)70360-9","volume":"132","author":"LJ Brooks","year":"1998","unstructured":"Brooks LJ, Stephens BM, Bacevice AM (1998) Adenoid size is related to severity but not the number of episodes of obstructive apnea in children. J Pediatr 132(4):682\u2013686","journal-title":"J Pediatr"},{"issue":"5","key":"2943_CR16","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1097\/00005537-200405000-00014","volume":"114","author":"LH Nguyen","year":"2004","unstructured":"Nguyen LH, Manoukian JJ, Yoskovitch A, Al-Sebeih KH (2004) Adenoidectomy: selection criteria for surgical cases of otitis media. Laryngoscope 114(5):863\u2013866. https:\/\/doi.org\/10.1097\/00005537-200405000-00014","journal-title":"Laryngoscope"},{"issue":"4","key":"2943_CR17","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.ijporl.2009.12.019","volume":"74","author":"SZ Toros","year":"2010","unstructured":"Toros SZ, Kilicoglu G, Noseri H, Naiboglu B, Kalaycik C, Kulekci S, Karaca CT, Habesoglu T (2010) Does adenoid hypertrophy really have effect on tympanometry? Int J Pediatr Otorhinolaryngol 74(4):365\u2013368. https:\/\/doi.org\/10.1016\/j.ijporl.2009.12.019","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"8","key":"2943_CR18","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/0895-4356(96)00025-x","volume":"49","author":"GW Sun","year":"1996","unstructured":"Sun GW, Shook TL, Kay GL (1996) Inappropriate use of bivariable analysis to screen risk factors for use in multivariable analysis. J Clin Epidemiol 49(8):907\u2013916. https:\/\/doi.org\/10.1016\/0895-4356(96)00025-x","journal-title":"J Clin Epidemiol"},{"issue":"7","key":"2943_CR19","doi-asserted-by":"publisher","first-page":"11579","DOI":"10.18632\/oncotarget.14584","volume":"8","author":"A Schernberg","year":"2017","unstructured":"Schernberg A, Moureau-Zabotto L, Rivin Del Campo E, Escande A, Ducreux M, Nguyen F, Goere D, Chargari C, Deutsch E (2017) Leukocytosis and neutrophilia predict outcome in locally advanced esophageal cancer treated with definitive chemoradiation. Oncotarget 8(7):11579\u201311588. https:\/\/doi.org\/10.18632\/oncotarget.14584","journal-title":"Oncotarget"},{"issue":"1","key":"2943_CR20","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.radonc.2017.06.009","volume":"124","author":"A Schernberg","year":"2017","unstructured":"Schernberg A, Huguet F, Moureau-Zabotto L, Chargari C, Rivin Del Campo E, Schlienger M, Escande A, Touboul E, Deutsch E (2017) External validation of leukocytosis and neutrophilia as a prognostic marker in anal carcinoma treated with definitive chemoradiation. Radiother Oncol 124(1):110\u2013117. https:\/\/doi.org\/10.1016\/j.radonc.2017.06.009","journal-title":"Radiother Oncol"},{"issue":"5","key":"2943_CR21","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/coa.12289","volume":"39","author":"M Mutlu","year":"2014","unstructured":"Mutlu M, Vuralkan E, Yardim Akaydin S, Akin I, Miser E (2014) Effects of adenoid\/tonsillectomy on inflammatory response in snoring children with witnessed apnoea. Clin Otolaryngol 39(5):266\u2013271. https:\/\/doi.org\/10.1111\/coa.12289","journal-title":"Clin Otolaryngol"},{"issue":"4","key":"2943_CR22","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1017\/s0022215115000559","volume":"129","author":"A Yenigun","year":"2015","unstructured":"Yenigun A (2015) The efficacy of tonsillectomy in chronic tonsillitis patients as demonstrated by the neutrophil-to-lymphocyte ratio. J Laryngol Otol 129(4):386\u2013391. https:\/\/doi.org\/10.1017\/s0022215115000559","journal-title":"J Laryngol Otol"},{"issue":"9","key":"2943_CR23","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1017\/s0022215115001747","volume":"129","author":"A Yenigun","year":"2015","unstructured":"Yenigun A, Karamanli H (2015) Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome. J Laryngol Otol 129(9):887\u2013892. https:\/\/doi.org\/10.1017\/s0022215115001747","journal-title":"J Laryngol Otol"},{"issue":"12","key":"2943_CR24","doi-asserted-by":"publisher","first-page":"4111","DOI":"10.1007\/s00405-016-3983-8","volume":"273","author":"M Kar","year":"2016","unstructured":"Kar M, Altintoprak N, Muluk NB, Ulusoy S, Bafaqeeh SA, Cingi C (2016) Antileukotrienes in adenotonsillar hypertrophy: a review of the literature. Eur Arch Otorhinolaryngol 273(12):4111\u20134117. https:\/\/doi.org\/10.1007\/s00405-016-3983-8","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"4","key":"2943_CR25","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1007\/s12565-016-0350-1","volume":"92","author":"A Sagiroglu","year":"2017","unstructured":"Sagiroglu A, Acer N, Okuducu H, Ertekin T, Erkan M, Durmaz E, Aydin M, Yilmaz S, Zararsiz G (2017) Palatine tonsil volume estimation using different methods after tonsillectomy. Anat Sci Int 92(4):500\u2013508. https:\/\/doi.org\/10.1007\/s12565-016-0350-1","journal-title":"Anat Sci Int"},{"issue":"4","key":"2943_CR26","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.otohns.2010.01.013","volume":"142","author":"JH Wang","year":"2010","unstructured":"Wang JH, Chung YS, Cho YW, Kim DY, Yi JS, Bae JS, Shim MJ (2010) Palatine tonsil size in obese, overweight, and normal-weight children with sleep-disordered breathing. Otolaryngol Head Neck Surg 142(4):516\u2013519. https:\/\/doi.org\/10.1016\/j.otohns.2010.01.013","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"6","key":"2943_CR27","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1177\/0194599811400683","volume":"144","author":"J Nolan","year":"2011","unstructured":"Nolan J, Brietzke SE (2011) Systematic review of pediatric tonsil size and polysomnogram-measured obstructive sleep apnea severity. Otolaryngol Head Neck Surg 144(6):844\u2013850. https:\/\/doi.org\/10.1177\/0194599811400683","journal-title":"Otolaryngol Head Neck Surg"}],"container-title":["Indian Journal of Otolaryngology and Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12070-021-02943-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12070-021-02943-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12070-021-02943-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T19:47:19Z","timestamp":1675367239000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12070-021-02943-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,25]]},"references-count":27,"journal-issue":{"issue":"S3","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["2943"],"URL":"https:\/\/doi.org\/10.1007\/s12070-021-02943-9","relation":{},"ISSN":["2231-3796","0973-7707"],"issn-type":[{"value":"2231-3796","type":"print"},{"value":"0973-7707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,25]]},"assertion":[{"value":"23 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Informed consent was obtained from caregivers of all individual participants included in the study. The following statement was signed by both parents: \u201cI hereby provide our consent for clinical information relating to my child\u2019s case to be reported in a medical publication. I understand that the child\u2019s name and initials will not be published and that efforts will be made to conceal his\/her identity, but that anonymity cannot be guaranteed. As a minor, my child is not able to provide consent independently.\u201d","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Childrens\u2019 Hospital of Patras Research Ethics Committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from caregivers of all individual participants included in the study. The following statement was signed by both parents: \u201cI hereby provide consent for my child to participate in the research project conducted by the Otolaryngology Department of Childrens\u2019 Hospital of Patras. The details of this project have been explained to me all my questions were satisfactorily answered. As a minor, my child is not able to provide consent independently.\u201d","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}}]}}