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A total of 281 patients were included and divided into three categories: patients with LCRS, patients with DCRS, and a normal control group. The frequency of anatomical variation, the demographic information, disease type (with or without polyps), symptom visual analogue scale (VAS) scores and Lund-Mackay (L-M) scores were calculated and compared.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Results<\/jats:title>\n              <jats:p>Anatomical variants were observed more frequently in LCRS than DCRS (P\u2009&lt;\u20090.05). The frequency of variation was higher in the LCRSwNP group than the DCRSwNP group (P\u2009&lt;\u20090.05), and higher in the LCRSsNP group than the DCRSsNP group (P\u2009&lt;\u20090.05). The L-M scores for patients with DCRS with nasal polyps were significantly higher (14.96\u2009\u00b1\u20096.15) than those of patients with DCRS without nasal polyps (6.80\u2009\u00b1\u20095.00) and also significantly higher (3.78\u2009\u00b1\u20092.07) than those of patients with LCRS with nasal polyps (2.63\u2009\u00b1\u20091.12; P\u2009&lt;\u20090.05). A poor correlation was observed between the severity of symptoms and the performance of CT scans in CRS (R\u2009=\u20090.29, P\u2009&lt;\u20090.01).<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Conclusion<\/jats:title>\n              <jats:p>Anatomical variants were common in CRS, and possibly correlated with LCRS but not with DCRS. The frequency of anatomical variation is not associated with the occurrence of polyps. CT could reflect the severity of disease symptoms to some extent.<\/jats:p>\n            <\/jats:sec>","DOI":"10.1007\/s12070-022-03370-0","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T18:23:52Z","timestamp":1676053432000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Roles of Anatomical Abnormalities in Localized and Diffuse Chronic Rhinosinusitis"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8994-6622","authenticated-orcid":false,"given":"Lei","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yucheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"issue":"Suppl S29","key":"3370_CR1","first-page":"1","volume":"58","author":"WJ Fokkens","year":"2020","unstructured":"Fokkens WJ, Lund VJ, Hopkins C et al (2020) European position paper on Rhinosinusitis and nasal polyps 2020. 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