{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T16:01:48Z","timestamp":1779379308705,"version":"3.53.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s12070-023-04416-7","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T22:02:36Z","timestamp":1703714556000},"page":"1796-1804","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outcome of Adjuvant Radiotherapy and Adjuvant Chemoradiation for Oral Cancers with Close Margins of Resection"],"prefix":"10.1007","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0256-8949","authenticated-orcid":false,"given":"Lini","family":"Joseph","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M. Azeem","family":"Mohiyuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. N.","family":"Manjunath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kalyani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,27]]},"reference":[{"key":"4416_CR1","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1002\/ijc.30201","volume":"139","author":"C Laprise","year":"2016","unstructured":"Laprise C, Shahul HP, Madathil SA, Thekkepurakkal AS, Castonguay G, Varghese I, Shiraz S, Allison P, Schlecht NF, Rousseau MC, Franco EL, Nicolau B (2016) Periodontal diseases and risk of oral cancer in Southern India: results from the HeNCe life study. Int J Cancer 139:1512\u20131519. https:\/\/doi.org\/10.1002\/ijc.30201","journal-title":"Int J Cancer"},{"issue":"1","key":"4416_CR2","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s13014-017-0910-0","volume":"12","author":"KH Fan","year":"2017","unstructured":"Fan KH, Chen YC, Lin CY, Kang CJ, Lee LY, Huang SF et al (2017) Postoperative radiotherapy with or without concurrent chemotherapy for oral squamous cell carcinoma in patients with three or more minor risk factors: a propensity score matching analysis. Radiat Oncol 12(1):184","journal-title":"Radiat Oncol"},{"key":"4416_CR3","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1001\/jamaoto.2017.0548","volume":"143","author":"KK Tasche","year":"2017","unstructured":"Tasche KK, Buchakjian MR, Pagedar NA, Sperry SM (2017) Definition of \u201cclose margin\u201d in oral cancer surgery and association of margin distance with local recurrence rate. JAMA Otolaryngol Head Neck Surg 143:1166\u20131172","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"Suppl 1","key":"4416_CR4","first-page":"E2197","volume":"38","author":"RW Smits","year":"2016","unstructured":"Smits RW, Koljenovic S, Hardillo JA, Ten Hove I, Meeuwis CA, Sewnaik A et al (2016) Resection margins in oral cancer surgery: room for improvement. Head Neck 38(Suppl 1):E2197\u2013E2203","journal-title":"Head Neck"},{"issue":"19","key":"4416_CR5","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1056\/NEJMoa032646","volume":"350","author":"JS Cooper","year":"2004","unstructured":"Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB et al (2004) Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 350(19):1937\u20131944","journal-title":"N Engl J Med"},{"key":"4416_CR6","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1002\/hed.20279","volume":"27","author":"J Bernier","year":"2005","unstructured":"Bernier J, Cooper J, Pajak T et al (2005) Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (22931) and RTOG (9501). Head Neck 27:843\u2013850","journal-title":"Head Neck"},{"key":"4416_CR7","first-page":"661","volume":"26","author":"JM Han","year":"2007","unstructured":"Han JM, Wu GH, Zeng ZY, Chen FJ, Chen WK, Li H et al (2007) Postoperative recurrence-related factors of 125 patients with cT1-2N0 squamous cell carcinoma of the oral tongue. Ai Zheng Aizheng Chin J Cancer 26:661\u2013665","journal-title":"Ai Zheng Aizheng Chin J Cancer"},{"key":"4416_CR8","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s12253-013-9646-9","volume":"19","author":"S Yanamoto","year":"2013","unstructured":"Yanamoto S, Yamada S, Takahashi H, Kawasaki G, Ikeda H, Shiraishi T et al (2013) Predictors of locoregional recurrence in T1\u20132N0 tongue cancer patients. Pathol Oncol Res POR 19:795\u2013803","journal-title":"Pathol Oncol Res POR"},{"issue":"03","key":"4416_CR9","doi-asserted-by":"publisher","first-page":"355","DOI":"10.4103\/ijmpo.ijmpo_204_16","volume":"39","author":"S Chakrabarti","year":"2018","unstructured":"Chakrabarti S, Ghosh S, Qayyumi BN, Malik A, Nair D, Nair S, Chaturvedi P, Agrawal JP (2018) Besides and beyond histopathology; for adjuvant treatment in early tongue cancer. Indian J Med Paediatr Oncol 39(03):355\u2013362","journal-title":"Indian J Med Paediatr Oncol"},{"issue":"22","key":"4416_CR10","doi-asserted-by":"publisher","first-page":"e3770","DOI":"10.1097\/MD.0000000000003770","volume":"95","author":"WC Chen","year":"2016","unstructured":"Chen WC, Lai CH, Fang CC, Yang YH, Chen PC, Lee CP, Chen MF (2016) Identification of high-risk subgroups of patients with oral cavity cancer in need of postoperative adjuvant radiotherapy or chemo-radiotherapy. Medicine 95(22):e3770","journal-title":"Medicine"},{"issue":"4","key":"4416_CR11","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/S0002-9610(05)80555-0","volume":"160","author":"TR Loree","year":"1990","unstructured":"Loree TR, Strong EW (1990) Significance of positive margins in oral cavity squamous carcinoma. Am J Surg 160(4):410\u2013414","journal-title":"Am J Surg"},{"issue":"2","key":"4416_CR12","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1054\/ijom.2002.0469","volume":"33","author":"M Weijers","year":"2004","unstructured":"Weijers M, Snow GB, Bezemer DP, Van der Wal JE, Van Der Waal I (2004) The status of the deep surgical margins in tongue and floor of mouth squamous cell carcinoma and risk of local recurrence; an analysis of 68 patients. Int J Oral Maxillofac Surg 33(2):146\u2013149","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"110","key":"4416_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104883","volume":"1","author":"D Brinkman","year":"2020","unstructured":"Brinkman D, Callanan D, O\u2019Shea R, Jawad H, Feeley L, Sheahan P (2020) Impact of 3 mm margin on risk of recurrence and survival in oral cancer. Oral Oncol 1(110):104883","journal-title":"Oral Oncol"},{"issue":"14","key":"4416_CR14","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.1002\/cncr.31531","volume":"124","author":"E Fridman","year":"2018","unstructured":"Fridman E, Na\u2019ara S, Agarwal J, Amit M, Bachar G, Villaret AB, Brandao J, Cernea CR, Chaturvedi P, Clark J, Ebrahimi A (2018) The role of adjuvant treatment in early-stage oral cavity squamous cell carcinoma: an international collaborative study. Cancer 124(14):2948\u20132955","journal-title":"Cancer"},{"issue":"3","key":"4416_CR15","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S1368-8375(98)00113-4","volume":"35","author":"JA Woolgar","year":"1999","unstructured":"Woolgar JA, Rogers S, West CR, Errington RD, Brown JS, Vaughan ED (1999) Survival and patterns of recurrence in 200 oral cancer patients treated by radical surgery and neck dissection. Oral Oncol 35(3):257\u2013265","journal-title":"Oral Oncol"},{"key":"4416_CR16","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/S0002-9610(05)80555-0","volume":"160","author":"TR Loree","year":"1990","unstructured":"Loree TR, Strong EW (1990) Significance of positive margins in oral cavity squamous carcinoma. Am J Surg 160:410\u2013414","journal-title":"Am J Surg"},{"key":"4416_CR17","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.tripleo.2008.11.013","volume":"107","author":"R Nason","year":"2009","unstructured":"Nason R, Binahmed A, Pathak K, Abdoh A, Sandor G (2009) What is the adequate margin of surgical resection in oral cancer? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:625\u2013629","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"4416_CR18","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1748-717X-5-79","volume":"5","author":"WY Chiou","year":"2010","unstructured":"Chiou WY, Lin HY, Hsu FC, Lee MS, Ho HC, Su YC et al (2010) Buccal mucosa carcinoma: surgical margin less than 3 mm, not 5 mm, predicts locoregional recurrence. Radiat Oncol 5:79","journal-title":"Radiat Oncol"},{"issue":"6","key":"4416_CR19","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.oraloncology.2014.02.014","volume":"50","author":"EA Dik","year":"2014","unstructured":"Dik EA, Willems SM, Ipenburg NA, Adriaansens SO, Rosenberg AJ, van Es RJ (2014) Resection of early oral squamous cell carcinoma with positive or close margins: relevance of adjuvant treatment in relation to local recurrence: margins of 3 mm as safe as 5 mm. Oral Oncol 50(6):611\u2013615","journal-title":"Oral Oncol"},{"key":"4416_CR20","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1001\/jamaoto.2016.4238","volume":"143","author":"DK Zanoni","year":"2017","unstructured":"Zanoni DK, Migliacci JC, Xu B, Katabi N, Montero PH, Ganly I et al (2017) A proposal to redefine close surgical margins in squamous cell carcinoma of the oral tongue. JAMA Otolaryngol Head Neck Surg 143:555\u2013560","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"1","key":"4416_CR21","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3969\/j.issn.2095-3941.2012.01.005","volume":"9","author":"H Eldeeb","year":"2012","unstructured":"Eldeeb H, Macmillan C, Elwell C, Hammod A (2012) The effect of the surgical margins on the outcome of patients with head and neck squamous cell carcinoma: single institution experience. Cancer Biol Med 9(1):29\u201333. https:\/\/doi.org\/10.3969\/j.issn.2095-3941.2012.01.005","journal-title":"Cancer Biol Med"},{"issue":"13","key":"4416_CR22","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1002\/cncr.28081","volume":"119","author":"S Ch'Ng","year":"2013","unstructured":"Ch\u2019Ng S, Corbett-Burns S, Stanton N, Gao K, Shannon K, Clifford A, Gupta R, Clark JR (2013) Close margin alone does not warrant postoperative adjuvant radiotherapy in oral squamous cell carcinoma. Cancer 119(13):2427\u20132437","journal-title":"Cancer"},{"issue":"8","key":"4416_CR23","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.oraloncology.2006.09.010","volume":"43","author":"JS Brown","year":"2007","unstructured":"Brown JS, Blackburn TK, Woolgar JA, Lowe D, Errington RD, Vaughan ED, Rogers SN (2007) A comparison of outcomes for patients with oral squamous cell carcinoma at intermediate risk of recurrence treated by surgery alone or with post-operative radiotherapy. Oral Oncol 43(8):764\u2013773","journal-title":"Oral Oncol"},{"issue":"4","key":"4416_CR24","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.ijrobp.2009.06.064","volume":"77","author":"KH Fan","year":"2010","unstructured":"Fan KH, Wang HM, Kang CJ, Lee LY, Huang SF, Lin CY, Chen EY, Chen IH, Liao CT, Chang JT (2010) Treatment results of postoperative radiotherapy on squamous cell carcinoma of the oral cavity: coexistence of multiple minor risk factors results in higher recurrence rates. Int J Radiat Oncol* Biol* Phys 77(4):1024\u20131029","journal-title":"Int J Radiat Oncol* Biol* Phys"},{"issue":"1","key":"4416_CR25","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/1748-717X-7-215","volume":"7","author":"DL Tsan","year":"2012","unstructured":"Tsan DL, Lin CY, Kang CJ, Huang SF, Fan KH, Liao CT, Chen IH, Lee LY, Wang HM, Chang JT (2012) The comparison between weekly and three-weekly cisplatin delivered concurrently with radiotherapy for patients with postoperative high-risk squamous cell carcinoma of the oral cavity. Radiat Oncol 7(1):215","journal-title":"Radiat Oncol"},{"issue":"3","key":"4416_CR26","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/lary.24938","volume":"125","author":"MP Herman","year":"2015","unstructured":"Herman MP, Dagan R, Amdur RJ, Morris CG, Werning JW, Vaysberg M, Mendenhall WM (2015) Postoperative radiotherapy for patients at high risk of recurrence of oral cavity squamous cell carcinoma. Laryngoscope 125(3):630\u2013635","journal-title":"Laryngoscope"},{"key":"4416_CR27","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1002\/hed.23729","volume":"37","author":"CP Barry","year":"2015","unstructured":"Barry CP, Ahmed F, Rogers SN, Lowe D, Bekiroglu F, Brown JS et al (2015) Influence of surgical margins on local recurrence in T1\/T2 oral squamous cell carcinoma. Head Neck 37:1176\u20131180","journal-title":"Head Neck"},{"key":"4416_CR28","doi-asserted-by":"publisher","first-page":"545372","DOI":"10.1155\/2014\/545372","volume":"2014","author":"S Gokavarapu","year":"2014","unstructured":"Gokavarapu S, Chander R, Parvataneni N, Puthamakula S (2014) Close margins in oral cancers: implication of close margin status in recurrence and survival of pT1N0 and pT2N0 oral cancers. Int J Surg Oncol 2014:545372. https:\/\/doi.org\/10.1155\/2014\/545372","journal-title":"Int J Surg Oncol"}],"container-title":["Indian Journal of Otolaryngology and Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12070-023-04416-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12070-023-04416-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12070-023-04416-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T13:14:30Z","timestamp":1711890870000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12070-023-04416-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,27]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["4416"],"URL":"https:\/\/doi.org\/10.1007\/s12070-023-04416-7","relation":{},"ISSN":["2231-3796","0973-7707"],"issn-type":[{"value":"2231-3796","type":"print"},{"value":"0973-7707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,27]]},"assertion":[{"value":"26 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no financial or proprietary interests in any material discussed in this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by Institutional Ethics Committee (IEC) no. SDUMC\/KLR\/IEC\/311.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}