{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:20:02Z","timestamp":1792110002174,"version":"4.4.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005743","name":"Universit\u00e0 Cattolica del Sacro Cuore","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005743","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ophthalmic vein thrombosis is a severe clinical entity with proptosis, eyelid swelling, orbital pain and reduction of visual acuity; its incidence is rare with 3\u20134 cases \/million \/year. Clinical manifestations result from venous congestion caused by septic (orbital cellulitis) or aseptic aetiologies (coagulopathies, trauma) and in some cases it could be associated with cavernous sinus thrombosis. In this paper, we describe a case report unique in the literature, of bilateral cavernous sinus and ophthalmic veins thrombosis due to both septic and aseptic causes characterized by unilateral sphenoid sinusitis sustained by <jats:italic>Trueperella pyogenes<\/jats:italic> infection. <jats:italic>Trueperella pyogenes<\/jats:italic> is an opportunistic animal pathogen, and its infections occur in both domestic and wild animals worldwide but are rare in humans; this is the first instance of human infection in the head and neck with an unknown hypercoagulable state.<\/jats:p>","DOI":"10.1007\/s12070-024-04505-1","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T04:41:45Z","timestamp":1707280905000},"page":"2840-2843","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bilateral cavernous sinus and ophthalmic vein thrombosis secondary to Trueperella pyogenes rhinosinusitis"],"prefix":"10.1007","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7820-3535","authenticated-orcid":false,"given":"Lea","family":"Calo\u2019","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Scarano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Brigato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Di Cintio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Galli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"4505_CR1","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1099\/jmm.0.016485-0","volume":"59","author":"K Kavitha","year":"2010","unstructured":"Kavitha K, Latha R, Udayashankar C et al (2010) Three cases of Arcanobacterium pyogenes-associated soft tissue infection. 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Antonie Van Leeuwenhoek 88:87\u2013102. https:\/\/doi.org\/10.1007\/s10482-005-2316-5","journal-title":"Antonie Van Leeuwenhoek"},{"key":"4505_CR4","doi-asserted-by":"publisher","unstructured":"Azamgarhi T, Warren S (2020) A case of Trueperella pyogenes causing prosthetic joint infection. J Bone Jt Infect 6(3):47\u201350. https:\/\/doi.org\/10.5194\/jbji-6-47-2020","DOI":"10.5194\/jbji-6-47-2020"},{"key":"4505_CR5","doi-asserted-by":"publisher","unstructured":"Pan J, Ho AL, Pendharkar AV, Sussman ES, Casazza M, Cheshier SH, Grant GA (2019) Brain abscess caused by Trueperella bernardiae in a child. Surg Neurol Int 10:35. https:\/\/doi.org\/10.4103\/sni.sni_376_17","DOI":"10.4103\/sni.sni_376_17"},{"key":"4505_CR6","doi-asserted-by":"publisher","unstructured":"Deliwala S, Beere T, Samji V, Mcdonald PJ, Bachuwa G (2020) When zoonotic organisms cross over-Trueperella pyogenes endocarditis presenting as a septic embolic stroke. Cureus 12(4):e7740. https:\/\/doi.org\/10.7759\/cureus.7740","DOI":"10.7759\/cureus.7740"},{"key":"4505_CR7","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.3390\/ijms20112737","volume":"20","author":"M Rzewuska","year":"2019","unstructured":"Rzewuska M, Kwiecien E, Chrobak-Chmiel D, Kizerwetter-Swida M, Stefanska I, Gierynska M (2019) Pathogenicity and virulence of Trueperella pyogenes: a review. Int J Mol Sci 20:2737. https:\/\/doi.org\/10.3390\/ijms20112737","journal-title":"Int J Mol Sci"},{"issue":"13","key":"4505_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.832458","volume":"15","author":"H Liang","year":"2022","unstructured":"Liang H, Wang B, Wang J, Ma B, Zhang W (2022) Pyolysin of Trueperella pyogenes induces pyroptosis and IL-1\u03b2 release in murine macrophages through Potassium\/NLRP3\/Caspase-1\/Gasdermin D pathway. Front Immunol 15(13):832458. https:\/\/doi.org\/10.3389\/fimmu.2022.832458","journal-title":"Front Immunol"}],"container-title":["Indian Journal of Otolaryngology and Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12070-024-04505-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12070-024-04505-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12070-024-04505-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T18:10:46Z","timestamp":1718215846000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12070-024-04505-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,7]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["4505"],"URL":"https:\/\/doi.org\/10.1007\/s12070-024-04505-1","relation":{},"ISSN":["2231-3796","0973-7707"],"issn-type":[{"value":"2231-3796","type":"print"},{"value":"0973-7707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,7]]},"assertion":[{"value":"5 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare the absence of any financial support or relationship that may pose a conflict of interest. The patient gave her informed consent for the publication of the case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Statement"}}]}}