{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T13:55:58Z","timestamp":1769781358424,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T00:00:00Z","timestamp":1237248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1007\/s12072-009-9127-0","type":"journal-article","created":{"date-parts":[[2009,3,16]],"date-time":"2009-03-16T18:01:11Z","timestamp":1237226471000},"page":"371-377","source":"Crossref","is-referenced-by-count":26,"title":["Association of IL-18 promoter polymorphism with liver disease severity in HCV-infected patients"],"prefix":"10.1007","volume":"3","author":[{"given":"K.","family":"Manohar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. V.","family":"Suneetha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Sukriti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirupama Trehan","family":"Pati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek C.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed","family":"Hissar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puja","family":"Sakhuja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,3,17]]},"reference":[{"issue":"2","key":"9127_CR1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1055\/s-2000-9947","volume":"20","author":"M Lechmann","year":"2000","unstructured":"Lechmann M, Liang TJ. Vaccine development for hepatitis C. Semin Liver Dis 2000;20(2):211\u2013226. doi: 10.1055\/s-2000-9947","journal-title":"Semin Liver Dis"},{"issue":"2","key":"9127_CR2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1258\/0007142991902457","volume":"55","author":"AV Hill","year":"1999","unstructured":"Hill AV. Genetics and genomics of infectious disease susceptibility. Br Med Bull 1999;55(2):401\u2013413. doi: 10.1258\/0007142991902457","journal-title":"Br Med Bull"},{"key":"9127_CR3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/jmv.10533","volume":"72","author":"A Goyal","year":"2004","unstructured":"Goyal A, Syed K, Sakhuja P, Malhotra V, Arora N, Sarin SK. Association of TNF-\u03b2 polymorphism with disease severity among patients infected with hepatitis C virus. J Med Virol 2004;72:60\u201365. doi: 10.1002\/jmv.10533","journal-title":"J Med Virol"},{"issue":"6","key":"9127_CR4","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1089\/152581601317210863","volume":"10","author":"D Zecchina","year":"2001","unstructured":"Zecchina D, Novick M, Rubinstein V, Barak C, Dinarello H, Nagler A. Interleukin-18 binding protein in acute graft versus host disease and engraftment following allogeneic peripheral blood stem cell transplants. J Hematother Stem Cell Res 2001;10(6):769\u2013776. doi: 10.1089\/152581601317210863","journal-title":"J Hematother Stem Cell Res"},{"issue":"4","key":"9127_CR5","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.rmed.2006.08.019","volume":"101","author":"R Kieszko","year":"2006","unstructured":"Kieszko R, Krawczyk P, Jankowska O, Chocholska S, Krol A, Milanowski J. The clinical significance of interleukin 18 assessment in sarcoidosis patients. Respir Med 2006;101(4):722\u2013728. doi: 10.1016\/j.rmed.2006.08.019","journal-title":"Respir Med"},{"issue":"2","key":"9127_CR6","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1046\/j.1365-2249.2002.01911.x","volume":"129","author":"D Kaser","year":"2002","unstructured":"Kaser D, Novick M, Rubeinstein B, Siegmund B, Enrich RO, Koch W, et al. Interferon-\u03b1 induces interleukin-18 binding protein in chronic hepatitis C patients. Clin Exp Immunol 2002;129(2):332\u2013338. doi: 10.1046\/j.1365-2249.2002.01911.x","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"9127_CR7","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/ijc.21367","volume":"118","author":"M Asakawa","year":"2006","unstructured":"Asakawa M, Kono H, Amemiya H, Matsuda M, Suzuki T, Maki A, et al. Role of interleukin-18 and its receptor in hepatocellular carcinoma associated with hepatitis C virus infection. Int J Cancer 2006;118(3):564\u2013570. doi: 10.1002\/ijc.21367","journal-title":"Int J Cancer"},{"issue":"6","key":"9127_CR8","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1165\/rcmb.2003-0306OC","volume":"31","author":"K Yasuhiko","year":"2004","unstructured":"Yasuhiko K, Tomoaki H, Okamoto M, Kato S, Koda Y, Nagata N, et al. Enhanced expression of interleukin-18 and its receptor in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 2004;31(6):619\u2013625. doi: 10.1165\/rcmb.2003-0306OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"9127_CR9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1743-422X-2-88","volume":"2","author":"PA Zhang","year":"2005","unstructured":"Zhang PA, Wu JM, Li Y, Yang XS. A general method for nested RT-PCR amplification and sequencing the complete HCV genotype 1 open reading frame. Virol J 2005;2:88. doi: 10.1186\/1743-422X-2-88","journal-title":"Virol J"},{"issue":"21","key":"9127_CR10","doi-asserted-by":"crossref","first-page":"10702","DOI":"10.1128\/JVI.76.21.10702-10707.2002","volume":"76","author":"K Kimura","year":"2002","unstructured":"Kimura K, Kakimi K, Wieland S, Guidotti LG, Chisari FV. Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice. J Virol 2002;76(21):10702\u201310707. doi: 10.1128\/JVI.76.21.10702-10707.2002","journal-title":"J Virol"},{"issue":"12","key":"9127_CR11","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1097\/01.MIB.0000187574.41290.b1","volume":"11","author":"J Glas","year":"2005","unstructured":"Glas J, Torok HP, Tonenchi L, Kapser J, Schiemann U, Muller-Myhsok B, et al. Association of polymorphisms in the interleukin-18 gene in patients with Crohn\u2019s disease depending on the CARD15\/NOD2 genotype. Inflamm Bowel Dis 2005;11(12):1031\u20131037. doi: 10.1097\/01.MIB.0000187574.41290.b1","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"9127_CR12","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/CIRCULATIONAHA.104.519702","volume":"112","author":"L Tiret","year":"2005","unstructured":"Tiret L, Godefroy T, Lubos E, Nicaud V, Tregouet DA, Barbaux S, et al. Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease. Circulation 2005;112(5):643\u2013650. doi: 10.1161\/CIRCULATIONAHA.104.519702","journal-title":"Circulation"},{"issue":"5\u20136","key":"9127_CR13","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00251-006-0104-7","volume":"58","author":"L Segat","year":"2006","unstructured":"Segat L, Bevilacqua D, Boniotto M, Arraes LC, de Souza PR, de Lima Filho JL, et al. IL-18 gene promoter polymorphism is involved in HIV-1 infection in a Brazilian pediatric population. Immunogenetics 2006;58(5\u20136):471\u2013473","journal-title":"Immunogenetics"},{"key":"9127_CR14","doi-asserted-by":"crossref","unstructured":"Goodman ZD, Ishak KG. Histopathology of hepatitis C virus infection. Semin Liver Dis. 1995;15(1):70\u201381, Review","DOI":"10.1055\/s-2007-1007264"},{"issue":"8722","key":"9127_CR15","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/0140-6736(90)92487-3","volume":"336","author":"JA Garson","year":"1990","unstructured":"Garson JA, Tuke PW, Makris M, Briggs M, Machin SJ, Preston FE, et al. Demonstration of viraemia patterns in haemophiliacs treated with hepatitis-C-virus-contaminated factor VIII concentrates. Lancet 1990;336(8722):1022\u20131025. doi: 10.1016\/0140-6736(90)92487-3","journal-title":"Lancet"},{"issue":"2","key":"9127_CR16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0003-2697(89)90430-2","volume":"180","author":"MB Johns","year":"1989","unstructured":"Johns MB, Paulus-Thomas JE. Purification of human genomic DNA from whole blood using sodium perchlorate in place of phenol. Anal Biochem 1989;180(2):276\u2013278. doi: 10.1016\/0003-2697(89)90430-2","journal-title":"Anal Biochem"},{"key":"9127_CR17","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0165-5728(00)00407-0","volume":"112","author":"V Giedraitis","year":"2001","unstructured":"Giedraitis V, He B, Huang WX, Hillert J. Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation. J Neuroimmunol 2001;112:146\u2013152. doi: 10.1016\/S0165-5728(00)00407-0","journal-title":"J Neuroimmunol"},{"issue":"11","key":"9127_CR18","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/labinvest.3700473","volume":"86","author":"D Togbe","year":"2006","unstructured":"Togbe D, Aurore G, Noulin N, Quesniaux VF, Schnyder-Candrian S, Schnyder B, et al. Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways. Lab Invest 2006;86(11):1126\u20131135","journal-title":"Lab Invest"},{"issue":"41","key":"9127_CR19","doi-asserted-by":"crossref","first-page":"15136","DOI":"10.1073\/pnas.0607181103","volume":"103","author":"H Negishi","year":"2006","unstructured":"Negishi H, Fujita Y, Yanai H, Sakaguchi S, Ouyang X, Shinohara M, et al. Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. Proc Natl Acad Sci USA 2006;103(41):15136\u201315141. doi: 10.1073\/pnas.0607181103","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"9127_CR20","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1093\/intimm\/dxf108","volume":"14","author":"M Abraham","year":"2002","unstructured":"Abraham M, Shapiro S, Lahat N, Miller A. The role of IL-18 and IL-12 in the modulation of matrix metalloproteinases and their tissue inhibitors in monocytic cells. Int Immunol 2002;14(12):1449\u20131457. doi: 10.1093\/intimm\/dxf108","journal-title":"Int Immunol"},{"issue":"2","key":"9127_CR21","first-page":"144","volume":"36","author":"K Falasca","year":"2006","unstructured":"Falasca K, Ucciferri C, Dalessandro M, Zingariello P, Mancino P, Petrarca C, et al. Cytokine patterns correlate with liver damage in patients with chronic hepatitis B and C. Ann Clin Lab Sci 2006;36(2):144\u2013150","journal-title":"Ann Clin Lab Sci"},{"issue":"62","key":"9127_CR22","first-page":"547","volume":"52","author":"K Murata","year":"2005","unstructured":"Murata K, Yamamoto N, Kawakita T, Saito Y, Yamanaka Y, Sugimoto K, et al. Up-regulation of IL-18 by interferon alpha-2b\/ribavirin combination therapy induces an anti-viral effect in patients with chronic hepatitis C. Hepatogastroenterology 2005;52(62):547\u2013551","journal-title":"Hepatogastroenterology"},{"issue":"14","key":"9127_CR23","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1158\/1078-0432.CCR-06-0121","volume":"12","author":"MJ Robertson","year":"2006","unstructured":"Robertson MJ, Mier JW, Logan T, Atkins M, Koon H, Koch KM, et al. Clinical and biological effects of recombinant human interleukin-18 administered by intravenous infusion to patients with advanced cancer. Clin Cancer Res 2006;12(14):4265\u20134273","journal-title":"Clin Cancer Res"},{"key":"9127_CR24","doi-asserted-by":"crossref","unstructured":"Pawlik A, Kurzawski M, Czerny B, Gawronska-Szklarz B, Drozdzik M, Herczynska M. Interleukin-18 promoter polymorphism in patients with rheumatoid arthritis. Tissue Antigens. 2006;67(5):415\u2013418","DOI":"10.1111\/j.1399-0039.2006.00582.x"},{"key":"9127_CR25","doi-asserted-by":"crossref","unstructured":"Mojtahedi Z, Naeimi S, Farjadian S, Omrani GR, Ghaderi A. Association of IL-18 promoter polymorphisms with predisposition to Type 1 diabetes. Diabet Med. 2006;23(3):235\u2013239","DOI":"10.1111\/j.1464-5491.2006.01786.x"},{"key":"9127_CR26","unstructured":"Boraska V, Terzi\u0107 J, Skrabi\u0107 V, Ca\u0107ev T, Bucevi\u0107-Popovi\u0107 V, Peruzovi\u0107 M, et al. NeuroD1 gene and interleukin-18 gene polymorphisms in type 1 diabetes in Dalmatian population of Southern Croatia. Croat Med J. 2006;47(4):571\u2013578"},{"key":"9127_CR27","doi-asserted-by":"crossref","unstructured":"Lee HM, Park SA, Chung SW, Woo JS, Chae SW, Lee SH, et al. Interleukin-18\/607 gene polymorphism in allegic rhinitis. Int J Pediatric Otorhinoalaryngol. 2006;70(6):1085\u20131088","DOI":"10.1016\/j.ijporl.2005.11.006"},{"key":"9127_CR28","unstructured":"Jang WC, Park SB, Nam YH, Lee SS, Kim JW, Chang IS, et al. Interleukin-18 gene polymorphisms in Korean patients with Beh\u00e7et\u2019s disease. Clin Exp Rheumatol. 2005;23(4 Suppl 38):S59\u2013S63"},{"key":"9127_CR29","doi-asserted-by":"crossref","unstructured":"Zhou Y, Yamaguchi E, Fukui Y, Konno S, Maeda Y, Kimata K, et al. Enhanced expression of interleukin-18 receptor alpha chain by CD4+ T cells in sarcoidosis. Chest. 2005;128(4):2497\u20132503","DOI":"10.1016\/S0012-3692(15)52663-9"},{"key":"9127_CR30","doi-asserted-by":"crossref","unstructured":"Folwaczny M, Glas J, T\u00f6r\u00f6k HP, Tonenchi L, Paschos E, Bauer B, et al. Polymorphisms of the interleukin-18 gene in periodontitis patients. J Clin Periodontol. 2005;32(5):530\u2013534","DOI":"10.1111\/j.1600-051X.2005.00711.x"},{"key":"9127_CR31","doi-asserted-by":"crossref","unstructured":"Novak N, Kruse S, Potreck J, Maintz L, Jenneck C, Weidinger S, et al. Single nucleotide polymorphisms of IL-18 gene are associated with atopic eczema. J Allergy Clin Immunology. 2005;115(4):828\u2013833","DOI":"10.1016\/j.jaci.2005.01.030"},{"key":"9127_CR32","doi-asserted-by":"crossref","unstructured":"Aizawa Y, Sutoh S, Matsuoka M, Negishi M, Torii A, Miyakawa Y, et al. Association of interleukin-18 gene single nucleotide polymorphisms with susceptibility of inflammatory bowel disease. Tissue Antigens. 2005;65(1):88\u201392","DOI":"10.1111\/j.1399-0039.2005.00336.x"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-009-9127-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12072-009-9127-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-009-9127-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T03:37:04Z","timestamp":1559446624000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12072-009-9127-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,17]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["9127"],"URL":"https:\/\/doi.org\/10.1007\/s12072-009-9127-0","relation":{},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"value":"1936-0533","type":"print"},{"value":"1936-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,17]]}}}