{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:20:46Z","timestamp":1761862846113},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,6,16]],"date-time":"2009-06-16T00:00:00Z","timestamp":1245110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1007\/s12072-009-9137-y","type":"journal-article","created":{"date-parts":[[2009,6,15]],"date-time":"2009-06-15T11:23:19Z","timestamp":1245064999000},"page":"490-496","source":"Crossref","is-referenced-by-count":14,"title":["The state of cholesterol metabolism in the liver of patients with primary biliary cirrhosis: the role of MDR3 expression"],"prefix":"10.1007","volume":"3","author":[{"given":"Munechika","family":"Enjoji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoko","family":"Yada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Fujino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Yoshimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Yada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiko","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobito","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoyuki","family":"Kohjima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinobu","family":"Taketomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Maehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Kotoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Nakamuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,6,16]]},"reference":[{"key":"9137_CR1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cell.2005.12.022","volume":"124","author":"JL Goldstein","year":"2006","unstructured":"Goldstein JL, Debose-Boyd RA, Brown MS. Protein sensors for membrane sterols. Cell 2006;124:35\u201346","journal-title":"Cell"},{"key":"9137_CR2","first-page":"736","volume":"61","author":"G W\u00f3jcicka","year":"2007","unstructured":"W\u00f3jcicka G, Jamroz-Wi\u015bniewska A, Horoszewicz K, Be\u0142towski J. Liver X receptors (LXRs); part I: structure, function, regulation of activity, and role in lipid metabolism. Postepy Hig Med Dosw 2007;61:736\u2013759","journal-title":"Postepy Hig Med Dosw"},{"key":"9137_CR3","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1080\/00498250802007930","volume":"38","author":"S Kidambi","year":"2008","unstructured":"Kidambi S, Patel SB. Cholesterol and non-cholesterol sterol transporters: ABCG5, ABCG8 and NPC1L1: a review. Xenobiotica 2008;38:1119\u20131139","journal-title":"Xenobiotica"},{"key":"9137_CR4","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1080\/00365520802008140","volume":"43","author":"M Kato","year":"2008","unstructured":"Kato M, Higuchi N, Enjoji M. Reduced expression of ATGL and CGI-58 in the liver may attribute to develop NAFLD in patients with insulin resistant background. Scand J Gastroenterol 2008;43:1018\u20131019","journal-title":"Scand J Gastroenterol"},{"key":"9137_CR5","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1042\/BC20040088","volume":"97","author":"KJ Erpecum Van","year":"2005","unstructured":"Van Erpecum KJ. Biliary lipids, water and cholesterol gallstones. Biol Cell 2005;97:815\u2013822","journal-title":"Biol Cell"},{"key":"9137_CR6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1034\/j.1478-3231.2003.00856.x","volume":"23","author":"PLM Jansen","year":"2003","unstructured":"Jansen PLM, Sturm E. Genetic cholestasis, causes and consequences for hepatobiliary transport. Liver Int 2003;23:315\u2013322","journal-title":"Liver Int"},{"key":"9137_CR7","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00424-006-0062-9","volume":"453","author":"RPJ Oude Elfrrink","year":"2007","unstructured":"Oude Elfrrink RPJ, Paulusma CC. Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein). Eur J Physiol 2007;453:601\u2013610","journal-title":"Eur J Physiol"},{"key":"9137_CR8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.hepres.2004.08.015","volume":"30","author":"T Matsumoto","year":"2004","unstructured":"Matsumoto T, Miyazaki H, Nakahashi Y, Hirohara J, Seli T, Inoue K, et al. Multidrug resistance3 is in situ detected in the liver of patients with primary biliary cirrhosis, and induced in human hepatoma cells by bezafibrate. Hepatol Res 2004;30:125\u2013136","journal-title":"Hepatol Res"},{"key":"9137_CR9","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1053\/jhep.2001.22646","volume":"33","author":"G Zollner","year":"2001","unstructured":"Zollner G, Fickert P, Zenz R, Fuchsbichler A, Stumptner C, Kenner L, et al. Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases. Hepatology 2001;33:633\u2013646","journal-title":"Hepatology"},{"key":"9137_CR10","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0168-8278(03)00096-5","volume":"38","author":"G Zollner","year":"2003","unstructured":"Zollner G, Fickert P, Silbert D, Fuchsbichler A, Marschall HU, Zatloukal K, et al. Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis. J Hepatol 2003;38:717\u2013727","journal-title":"J Hepatol"},{"key":"9137_CR11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/path.1379","volume":"200","author":"JE Ros","year":"2003","unstructured":"Ros JE, Libbrecht L, Geuken M, Jansen PLM, Roskams TAD. High expression of MDR1, MRP1, and MRP3 in the hepatic progenitor cell compartment and hepatocytes in severe human liver disease. J Pathol 2003;200:553\u2013560","journal-title":"J Pathol"},{"key":"9137_CR12","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0005-2736(99)00167-4","volume":"1461","author":"P Borst","year":"1999","unstructured":"Borst P, Evers R, Kool M, Wijnholds J. The multidrug resistance protein family. Biochim Biophys Acta 1999;1461:347\u2013357","journal-title":"Biochim Biophys Acta"},{"key":"9137_CR13","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00535-002-1102-7","volume":"38","author":"T Kanda","year":"2003","unstructured":"Kanda T, Yokosuka O, Imazeki F, Saisho H. Bezafibrate treatment: a new medical approach for PBC patients? J Gastroenterol 2003;38:573\u2013578","journal-title":"J Gastroenterol"},{"key":"9137_CR14","doi-asserted-by":"crossref","first-page":"894","DOI":"10.3748\/wjg.v10.i6.894","volume":"10","author":"K Dohmen","year":"2004","unstructured":"Dohmen K, Mizuta T, Nakamuta M, Shimohashi N, Ishibashi H, Yamamoto K. Fenofibrate for patients with asymptomatic primary biliary cirrhosis. World J Gastroenterol 2004;10:894\u2013898","journal-title":"World J Gastroenterol"},{"key":"9137_CR15","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1007\/s00535-006-1831-0","volume":"41","author":"R Kita","year":"2006","unstructured":"Kita R, Takamatsu S, Kimura T, Kokuryu H, Osaki Y, Tomono N. Bezafibrate may attenuate biliary damage associated with chronic liver diseases accompanied by high serum biliary enzyme levels. J Gastroenterol 2006;41:686\u2013692","journal-title":"J Gastroenterol"},{"key":"9137_CR16","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1042\/bj3140781","volume":"314","author":"J Chinale","year":"1996","unstructured":"Chinale J, Vollrath V, Wielandt AM, Amigo L, Rigotti A, Nervi F, et al. Fibrate induce mdr2 gene expression and biliary phospholipids secretion in the mouse. Biochem J 1996;314:781\u2013786","journal-title":"Biochem J"},{"key":"9137_CR17","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1194\/jlr.M400132-JLR200","volume":"45","author":"J Shoda","year":"2004","unstructured":"Shoda J, Inada Y, Tsuji A, Kusama H, Ueda T, Ikegami T, et al. Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPAR\u03b1-mediated redistribution of ABCB4. J Lipid Res 2004;45:1813\u20131825","journal-title":"J Lipid Res"},{"key":"9137_CR18","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1872-034X.2007.00069.x","volume":"37","author":"J Shoda","year":"2007","unstructured":"Shoda J, Okada K, Inada Y, Kusama H, Utsunomiya H, Oda K, et al. Bezafibrate induces multidrug-resistance P-glycoprotein 3 expression in cultured human hepatocytes and humanized livers of chimeric mice. Hepatol Res 2007;37:548\u2013556","journal-title":"Hepatol Res"},{"key":"9137_CR19","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S1386-6346(99)00033-9","volume":"16","author":"S Iwasaki","year":"1999","unstructured":"Iwasaki S, Tsuda K, Ueta H, Aono R, Ono M, Saibara T, et al. Bezafibrate may have a beneficial effect in pre-cirrhotic primary biliary cirrhosis. Hepatol Res 1999;16:12\u201318","journal-title":"Hepatol Res"},{"key":"9137_CR20","first-page":"580","volume-title":"Hepatology: Principles and Practice","author":"E Kuntz","year":"2001","unstructured":"Kuntz E, Kuntz HD. Hepatology: Principles and Practice. Berlin: Springer, 2001; 580\u2013590"},{"key":"9137_CR21","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/hep.20159","volume":"39","author":"C Pauli-Magnus","year":"2004","unstructured":"Pauli-Magnus C, Kerb R, Fattinger K, Lang T, Anwald B, Kullak-Ublick GA, et al. BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis. Hepatology 2004;39:779\u2013791","journal-title":"Hepatology"},{"key":"9137_CR22","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/hep.22382","volume":"48","author":"Y Ohishi","year":"2008","unstructured":"Ohishi Y, Nakamura M, Iio N, Higa S, Inayoshi M, Aiba Y, et al. Single-nucleotide polymorphism analysis of the multidrug resistance protein 3 gene for the detection of clinical progression in Japanese patients with primary biliary cirrhosis. Hepatology 2008;48:853\u2013862","journal-title":"Hepatology"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-009-9137-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12072-009-9137-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-009-9137-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T23:37:04Z","timestamp":1559432224000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12072-009-9137-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,16]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["9137"],"URL":"https:\/\/doi.org\/10.1007\/s12072-009-9137-y","relation":{},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"value":"1936-0533","type":"print"},{"value":"1936-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,16]]}}}